

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | negative T cell selection (GO:0043383) | 8.57786882 |
| 2 | positive regulation of gamma-delta T cell activation (GO:0046645) | 8.36249606 |
| 3 | regulation of gamma-delta T cell differentiation (GO:0045586) | 8.33366659 |
| 4 | positive T cell selection (GO:0043368) | 8.07120249 |
| 5 | regulation of gamma-delta T cell activation (GO:0046643) | 7.45305290 |
| 6 | positive regulation of antigen receptor-mediated signaling pathway (GO:0050857) | 7.37306447 |
| 7 | negative thymic T cell selection (GO:0045060) | 7.35229688 |
| 8 | T cell selection (GO:0045058) | 7.18402723 |
| 9 | positive thymic T cell selection (GO:0045059) | 7.14537621 |
| 10 | negative regulation of leukocyte mediated cytotoxicity (GO:0001911) | 6.77024506 |
| 11 | negative regulation of cell killing (GO:0031342) | 6.77024506 |
| 12 | V(D)J recombination (GO:0033151) | 6.73176684 |
| 13 | thymic T cell selection (GO:0045061) | 6.57040535 |
| 14 | * T cell receptor signaling pathway (GO:0050852) | 6.41584187 |
| 15 | positive regulation of interleukin-2 biosynthetic process (GO:0045086) | 6.36871275 |
| 16 | cellular response to interleukin-15 (GO:0071350) | 6.00184501 |
| 17 | response to interleukin-15 (GO:0070672) | 5.88835550 |
| 18 | interferon-gamma production (GO:0032609) | 5.86748185 |
| 19 | negative regulation of thymocyte apoptotic process (GO:0070244) | 5.61264558 |
| 20 | regulation of isotype switching to IgG isotypes (GO:0048302) | 5.55593138 |
| 21 | * T cell costimulation (GO:0031295) | 5.51311174 |
| 22 | antigen processing and presentation of endogenous peptide antigen (GO:0002483) | 5.49413344 |
| 23 | antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885) | 5.49413344 |
| 24 | * lymphocyte costimulation (GO:0031294) | 5.48447432 |
| 25 | activated T cell proliferation (GO:0050798) | 5.37279210 |
| 26 | leukocyte aggregation (GO:0070486) | 5.31355376 |
| 27 | * antigen receptor-mediated signaling pathway (GO:0050851) | 5.21668844 |
| 28 | regulation of T cell receptor signaling pathway (GO:0050856) | 5.06990315 |
| 29 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G | 5.01243014 |
| 30 | regulation of T cell tolerance induction (GO:0002664) | 4.99110013 |
| 31 | cytidine metabolic process (GO:0046087) | 4.96090240 |
| 32 | cytidine catabolic process (GO:0006216) | 4.96090240 |
| 33 | cytidine deamination (GO:0009972) | 4.96090240 |
| 34 | T cell differentiation (GO:0030217) | 4.76987911 |
| 35 | sequestering of actin monomers (GO:0042989) | 4.64690462 |
| 36 | regulation of interleukin-2 biosynthetic process (GO:0045076) | 4.60056030 |
| 37 | pyrimidine ribonucleoside catabolic process (GO:0046133) | 4.56853527 |
| 38 | regulation of regulatory T cell differentiation (GO:0045589) | 4.53995818 |
| 39 | regulation of antigen receptor-mediated signaling pathway (GO:0050854) | 4.52045481 |
| 40 | antigen processing and presentation of endogenous antigen (GO:0019883) | 4.50544316 |
| 41 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 4.48950351 |
| 42 | positive regulation of interleukin-2 production (GO:0032743) | 4.48104740 |
| 43 | T cell migration (GO:0072678) | 4.42727950 |
| 44 | alpha-beta T cell differentiation (GO:0046632) | 4.37986057 |
| 45 | positive regulation of granulocyte differentiation (GO:0030854) | 4.36938896 |
| 46 | mast cell activation (GO:0045576) | 4.36419842 |
| 47 | regulation of defense response to virus by virus (GO:0050690) | 4.27536675 |
| 48 | regulation of thymocyte apoptotic process (GO:0070243) | 4.17663516 |
| 49 | alpha-beta T cell activation (GO:0046631) | 4.17488377 |
| 50 | positive regulation of calcium-mediated signaling (GO:0050850) | 4.15036196 |
| 51 | DNA deamination (GO:0045006) | 4.11697136 |
| 52 | positive regulation of T cell chemotaxis (GO:0010820) | 4.07034147 |
| 53 | regulation of T cell chemotaxis (GO:0010819) | 4.07034147 |
| 54 | positive regulation of tolerance induction (GO:0002645) | 4.04924606 |
| 55 | T cell activation (GO:0042110) | 4.04033429 |
| 56 | Peyers patch development (GO:0048541) | 4.02431907 |
| 57 | mucosal-associated lymphoid tissue development (GO:0048537) | 4.02431907 |
| 58 | Arp2/3 complex-mediated actin nucleation (GO:0034314) | 3.93268935 |
| 59 | antigen processing and presentation via MHC class Ib (GO:0002475) | 3.88274121 |
| 60 | mast cell degranulation (GO:0043303) | 3.86569670 |
| 61 | mast cell activation involved in immune response (GO:0002279) | 3.86569670 |
| 62 | regulation of B cell receptor signaling pathway (GO:0050855) | 3.80343406 |
| 63 | regulation of activation of Janus kinase activity (GO:0010533) | 3.77686355 |
| 64 | regulation of chronic inflammatory response (GO:0002676) | 3.74796435 |
| 65 | positive regulation of alpha-beta T cell proliferation (GO:0046641) | 3.73152134 |
| 66 | regulation of B cell differentiation (GO:0045577) | 3.71116243 |
| 67 | tolerance induction (GO:0002507) | 3.70757633 |
| 68 | dendritic cell chemotaxis (GO:0002407) | 3.70102569 |
| 69 | regulation of alpha-beta T cell proliferation (GO:0046640) | 3.69307744 |
| 70 | somatic diversification of immune receptors via germline recombination within a single locus (GO:000 | 3.67692671 |
| 71 | somatic cell DNA recombination (GO:0016444) | 3.67692671 |
| 72 | T cell homeostasis (GO:0043029) | 3.62711283 |
| 73 | positive regulation of B cell differentiation (GO:0045579) | 3.60068034 |
| 74 | negative regulation of T cell receptor signaling pathway (GO:0050860) | 3.59069029 |
| 75 | positive regulation of natural killer cell mediated immunity (GO:0002717) | 3.57940063 |
| 76 | positive regulation of natural killer cell mediated cytotoxicity (GO:0045954) | 3.57940063 |
| 77 | regulation of interferon-gamma-mediated signaling pathway (GO:0060334) | 3.57742196 |
| 78 | regulation of lymphocyte chemotaxis (GO:1901623) | 3.57682097 |
| 79 | regulation of response to interferon-gamma (GO:0060330) | 3.57248205 |
| 80 | regulation of T cell mediated cytotoxicity (GO:0001914) | 3.56211719 |
| 81 | regulation of natural killer cell mediated cytotoxicity (GO:0042269) | 3.53360668 |
| 82 | regulation of natural killer cell mediated immunity (GO:0002715) | 3.53360668 |
| 83 | regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923) | 3.50936088 |
| 84 | regulation of leukocyte mediated cytotoxicity (GO:0001910) | 3.50917489 |
| 85 | positive regulation of interleukin-4 production (GO:0032753) | 3.50569582 |
| 86 | * immune response-activating cell surface receptor signaling pathway (GO:0002429) | 3.49763394 |
| 87 | regulation of tolerance induction (GO:0002643) | 3.48769456 |
| 88 | positive regulation of leukocyte mediated cytotoxicity (GO:0001912) | 3.43495421 |
| 89 | NIK/NF-kappaB signaling (GO:0038061) | 3.43031005 |
| 90 | lymph node development (GO:0048535) | 3.42744341 |
| 91 | regulation of interleukin-2 production (GO:0032663) | 3.42684692 |
| 92 | negative regulation of T cell apoptotic process (GO:0070233) | 3.40228636 |
| 93 | lymphocyte migration (GO:0072676) | 3.40156530 |
| 94 | somatic diversification of immune receptors (GO:0002200) | 3.39485960 |
| 95 | T cell lineage commitment (GO:0002360) | 3.37509120 |
| 96 | negative regulation of antigen receptor-mediated signaling pathway (GO:0050858) | 3.34003314 |
| 97 | positive regulation of lymphocyte mediated immunity (GO:0002708) | 3.33671314 |
| 98 | actin nucleation (GO:0045010) | 3.30682854 |
| 99 | cellular response to interleukin-4 (GO:0071353) | 3.29657423 |
| 100 | regulation of isotype switching (GO:0045191) | 3.29328349 |
| 101 | positive regulation of humoral immune response (GO:0002922) | 3.27186896 |
| 102 | positive regulation of isotype switching (GO:0045830) | 3.26967950 |
| 103 | negative regulation of T cell mediated immunity (GO:0002710) | 3.26472778 |
| 104 | T cell differentiation in thymus (GO:0033077) | 3.25525168 |
| 105 | negative regulation of leukocyte mediated immunity (GO:0002704) | 3.24846220 |
| 106 | * positive regulation of T cell activation (GO:0050870) | 3.21343415 |
| 107 | natural killer cell activation (GO:0030101) | 3.20810890 |
| 108 | regulation of cell killing (GO:0031341) | 3.20481288 |
| 109 | dendritic cell migration (GO:0036336) | 3.19684047 |
| 110 | CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294) | 3.19444377 |
| 111 | T-helper cell differentiation (GO:0042093) | 3.19444377 |
| 112 | lymphocyte differentiation (GO:0030098) | 3.16471389 |
| 113 | regulation of alpha-beta T cell activation (GO:0046634) | 3.16015078 |
| 114 | lymphocyte chemotaxis (GO:0048247) | 3.15522919 |
| 115 | positive regulation of T cell differentiation (GO:0045582) | 3.15252497 |
| 116 | T cell mediated immunity (GO:0002456) | 3.15045029 |
| 117 | positive regulation of T cell mediated immunity (GO:0002711) | 3.14887637 |
| 118 | cellular defense response (GO:0006968) | 3.14268508 |
| 119 | regulation of interleukin-4 production (GO:0032673) | 3.12645293 |
| 120 | positive regulation of cell killing (GO:0031343) | 3.12510021 |
| 121 | negative regulation of lymphocyte mediated immunity (GO:0002707) | 3.12383742 |
| 122 | regulation of type I interferon-mediated signaling pathway (GO:0060338) | 3.12151703 |
| 123 | negative regulation of viral genome replication (GO:0045071) | 3.11033030 |
| 124 | positive regulation of T cell mediated cytotoxicity (GO:0001916) | 3.10845336 |
| 125 | positive regulation of uterine smooth muscle contraction (GO:0070474) | 3.09974792 |
| 126 | positive regulation of lymphocyte migration (GO:2000403) | 3.09918994 |
| 127 | chemokine-mediated signaling pathway (GO:0070098) | 3.09720686 |
| 128 | positive regulation of alpha-beta T cell activation (GO:0046635) | 3.08700244 |
| 129 | positive regulation of defense response to virus by host (GO:0002230) | 3.08295822 |
| 130 | regulation of antigen processing and presentation of peptide antigen (GO:0002583) | 3.07987623 |
| 131 | lymphocyte homeostasis (GO:0002260) | 3.07650528 |
| 132 | * regulation of T cell activation (GO:0050863) | 3.06058892 |
| 133 | regulation of T cell differentiation (GO:0045580) | 3.03163338 |
| 134 | positive regulation of type I interferon-mediated signaling pathway (GO:0060340) | 3.02440275 |
| 135 | CD4-positive, alpha-beta T cell differentiation (GO:0043367) | 3.02251009 |
| 136 | leukocyte cell-cell adhesion (GO:0007159) | 3.01738848 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 7.35694686 |
| 2 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 5.80693248 |
| 3 | E2F7_22180533_ChIP-Seq_HELA_Human | 5.26644587 |
| 4 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 3.79888846 |
| 5 | MYC_22102868_ChIP-Seq_BL_Human | 3.65570902 |
| 6 | RUNX_20019798_ChIP-Seq_JUKART_Human | 3.65150183 |
| 7 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 3.62086503 |
| 8 | MYB_26560356_Chip-Seq_TH2_Human | 3.50756066 |
| 9 | FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse | 3.46829831 |
| 10 | STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 3.34339512 |
| 11 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 3.20340560 |
| 12 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 3.19974092 |
| 13 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 3.18076636 |
| 14 | UTX_26944678_Chip-Seq_JUKART_Human | 2.99660528 |
| 15 | MAF_26560356_Chip-Seq_TH1_Human | 2.99190382 |
| 16 | MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 2.78189699 |
| 17 | MYB_26560356_Chip-Seq_TH1_Human | 2.69975660 |
| 18 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 2.59154079 |
| 19 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 2.36744735 |
| 20 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 2.34636629 |
| 21 | GATA3_27048872_Chip-Seq_THYMUS_Human | 2.34506269 |
| 22 | VDR_21846776_ChIP-Seq_THP-1_Human | 2.26527245 |
| 23 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 2.21008033 |
| 24 | MAF_26560356_Chip-Seq_TH2_Human | 2.12913835 |
| 25 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 2.08717102 |
| 26 | KDM2B_26808549_Chip-Seq_HPB-ALL_Human | 2.02299733 |
| 27 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.94026451 |
| 28 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 1.93803008 |
| 29 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.91492501 |
| 30 | TCF7_22412390_ChIP-Seq_EML_Mouse | 1.88815980 |
| 31 | RUNX1_22412390_ChIP-Seq_EML_Mouse | 1.87691360 |
| 32 | E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 1.78174812 |
| 33 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.77730227 |
| 34 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.71734489 |
| 35 | SPI1_23547873_ChIP-Seq_NB4_Human | 1.71303986 |
| 36 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 1.68444772 |
| 37 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.65615025 |
| 38 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 1.62431987 |
| 39 | KDM2B_26808549_Chip-Seq_DND41_Human | 1.60912850 |
| 40 | VDR_24763502_ChIP-Seq_THP-1_Human | 1.59331498 |
| 41 | SCL_19346495_ChIP-Seq_HPC-7_Human | 1.56956058 |
| 42 | NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse | 1.55526233 |
| 43 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.53416268 |
| 44 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.53403219 |
| 45 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 1.52950179 |
| 46 | MEIS1_20887958_ChIP-Seq_HPC-7_Mouse | 1.50789093 |
| 47 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 1.49279611 |
| 48 | SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse | 1.49239569 |
| 49 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.47977244 |
| 50 | RUNX1_17652178_ChIP-ChIP_JURKAT_Human | 1.46456102 |
| 51 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.35923279 |
| 52 | VDR_23849224_ChIP-Seq_CD4+_Human | 1.34017884 |
| 53 | IRF8_27001747_Chip-Seq_BMDM_Mouse | 1.32884003 |
| 54 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 1.31049972 |
| 55 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 1.28651383 |
| 56 | GATA2_22383799_ChIP-Seq_G1ME_Mouse | 1.28436191 |
| 57 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.28186916 |
| 58 | CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human | 1.27518480 |
| 59 | SPI1_23127762_ChIP-Seq_K562_Human | 1.26452535 |
| 60 | BRD4_27068464_Chip-Seq_AML-cells_Mouse | 1.20571518 |
| 61 | BCL6_27268052_Chip-Seq_Bcells_Human | 1.18623848 |
| 62 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 1.14690820 |
| 63 | GATA3_26560356_Chip-Seq_TH2_Human | 1.14238874 |
| 64 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.12624344 |
| 65 | GATA1_22025678_ChIP-Seq_K562_Human | 1.10734766 |
| 66 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 1.10495246 |
| 67 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.07980229 |
| 68 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.06095761 |
| 69 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 1.04003751 |
| 70 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 1.02956968 |
| 71 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.02555472 |
| 72 | PU_27001747_Chip-Seq_BMDM_Mouse | 0.99195023 |
| 73 | KDM2B_26808549_Chip-Seq_JURKAT_Human | 0.98623366 |
| 74 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 0.98550573 |
| 75 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 0.96578345 |
| 76 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 0.96212870 |
| 77 | CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 0.95744285 |
| 78 | BCOR_27268052_Chip-Seq_Bcells_Human | 0.93788058 |
| 79 | GATA3_26560356_Chip-Seq_TH1_Human | 0.93485261 |
| 80 | PU.1_20513432_ChIP-Seq_Bcells_Mouse | 0.92777265 |
| 81 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 0.91849397 |
| 82 | LMO2_20887958_ChIP-Seq_HPC-7_Mouse | 0.90859353 |
| 83 | VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human | 0.90694477 |
| 84 | P300_27268052_Chip-Seq_Bcells_Human | 0.90116443 |
| 85 | RBPJ_21746931_ChIP-Seq_IB4-LCL_Human | 0.89940502 |
| 86 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.89237549 |
| 87 | TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse | 0.88206603 |
| 88 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 0.87036308 |
| 89 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 0.86939671 |
| 90 | XRN2_22483619_ChIP-Seq_HELA_Human | 0.86476249 |
| 91 | PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse | 0.86458612 |
| 92 | ELK1_19687146_ChIP-ChIP_HELA_Human | 0.83725417 |
| 93 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 0.82373516 |
| 94 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 0.82367043 |
| 95 | SPI1_20517297_ChIP-Seq_HL60_Human | 0.82001744 |
| 96 | PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 0.81504147 |
| 97 | GATA1_22383799_ChIP-Seq_G1ME_Mouse | 0.81477217 |
| 98 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 0.81345989 |
| 99 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 0.80784565 |
| 100 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.80293991 |
| 101 | PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse | 0.80173741 |
| 102 | CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse | 0.79837067 |
| 103 | RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.79718947 |
| 104 | GATA2_20887958_ChIP-Seq_HPC-7_Mouse | 0.79100482 |
| 105 | SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human | 0.79000998 |
| 106 | RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.78571028 |
| 107 | CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse | 0.78536760 |
| 108 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 0.78404489 |
| 109 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 0.76789975 |
| 110 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 0.74126604 |
| 111 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 0.72621118 |
| 112 | KDM5A_27292631_Chip-Seq_BREAST_Human | 0.71866867 |
| 113 | SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 0.71176175 |
| 114 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 0.70913513 |
| 115 | SA1_27219007_Chip-Seq_Bcells_Human | 0.70263298 |
| 116 | VDR_24787735_ChIP-Seq_THP-1_Human | 0.68485725 |
| 117 | CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse | 0.67735602 |
| 118 | TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.67614524 |
| 119 | CTCF_21964334_ChIP-Seq_BJAB-B_Human | 0.66729406 |
| 120 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 0.66227724 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003763_abnormal_thymus_physiology | 6.36539231 |
| 2 | MP0005671_abnormal_response_to | 5.06395788 |
| 3 | MP0002166_altered_tumor_susceptibility | 4.62992865 |
| 4 | MP0002006_tumorigenesis | 3.68745820 |
| 5 | MP0000685_abnormal_immune_system | 3.57143264 |
| 6 | MP0001835_abnormal_antigen_presentation | 3.45926814 |
| 7 | MP0000703_abnormal_thymus_morphology | 3.40524232 |
| 8 | MP0002398_abnormal_bone_marrow | 2.92385152 |
| 9 | MP0009333_abnormal_splenocyte_physiolog | 2.85980292 |
| 10 | MP0009785_altered_susceptibility_to | 2.85276006 |
| 11 | MP0001800_abnormal_humoral_immune | 2.83791577 |
| 12 | MP0006082_CNS_inflammation | 2.75682824 |
| 13 | MP0001790_abnormal_immune_system | 2.65626292 |
| 14 | MP0005387_immune_system_phenotype | 2.65626292 |
| 15 | MP0002420_abnormal_adaptive_immunity | 2.63537086 |
| 16 | MP0005000_abnormal_immune_tolerance | 2.62263720 |
| 17 | MP0001819_abnormal_immune_cell | 2.59649321 |
| 18 | MP0002723_abnormal_immune_serum | 2.57036925 |
| 19 | MP0002722_abnormal_immune_system | 2.55213830 |
| 20 | MP0004947_skin_inflammation | 2.51274358 |
| 21 | MP0000716_abnormal_immune_system | 2.47669613 |
| 22 | MP0010155_abnormal_intestine_physiology | 2.46866128 |
| 23 | MP0002405_respiratory_system_inflammati | 2.37598810 |
| 24 | MP0000689_abnormal_spleen_morphology | 2.22634963 |
| 25 | MP0005025_abnormal_response_to | 2.20413523 |
| 26 | MP0002452_abnormal_antigen_presenting | 2.16969384 |
| 27 | MP0003724_increased_susceptibility_to | 2.11162652 |
| 28 | MP0002933_joint_inflammation | 2.10523856 |
| 29 | MP0002132_abnormal_respiratory_system | 2.09264119 |
| 30 | MP0002429_abnormal_blood_cell | 1.99294217 |
| 31 | MP0002396_abnormal_hematopoietic_system | 1.95183371 |
| 32 | MP0001873_stomach_inflammation | 1.94725479 |
| 33 | MP0003866_abnormal_defecation | 1.92181951 |
| 34 | MP0003300_gastrointestinal_ulcer | 1.68973861 |
| 35 | MP0004381_abnormal_hair_follicle | 1.64237075 |
| 36 | MP0004808_abnormal_hematopoietic_stem | 1.61898127 |
| 37 | MP0010094_abnormal_chromosome_stability | 1.53601653 |
| 38 | MP0001845_abnormal_inflammatory_respons | 1.52541430 |
| 39 | MP0002277_abnormal_respiratory_mucosa | 1.52318441 |
| 40 | MP0005310_abnormal_salivary_gland | 1.52131340 |
| 41 | MP0002009_preneoplasia | 1.49273765 |
| 42 | MP0002148_abnormal_hypersensitivity_rea | 1.48749177 |
| 43 | MP0004510_myositis | 1.47849548 |
| 44 | MP0003436_decreased_susceptibility_to | 1.46254530 |
| 45 | MP0005409_darkened_coat_color | 1.45225017 |
| 46 | MP0002419_abnormal_innate_immunity | 1.42465543 |
| 47 | MP0005464_abnormal_platelet_physiology | 1.34150279 |
| 48 | MP0000858_altered_metastatic_potential | 1.30885100 |
| 49 | MP0001853_heart_inflammation | 1.22116470 |
| 50 | MP0005397_hematopoietic_system_phenotyp | 1.18722049 |
| 51 | MP0001545_abnormal_hematopoietic_system | 1.18722049 |
| 52 | MP0009278_abnormal_bone_marrow | 1.17216927 |
| 53 | MP0010352_gastrointestinal_tract_polyps | 1.16419548 |
| 54 | MP0002019_abnormal_tumor_incidence | 1.13060431 |
| 55 | MP0000015_abnormal_ear_pigmentation | 1.10494587 |
| 56 | MP0005174_abnormal_tail_pigmentation | 1.09535543 |
| 57 | MP0002095_abnormal_skin_pigmentation | 1.06900128 |
| 58 | MP0000490_abnormal_crypts_of | 1.05848838 |
| 59 | MP0003045_fibrosis | 1.01757889 |
| 60 | MP0008469_abnormal_protein_level | 0.93576043 |
| 61 | MP0001851_eye_inflammation | 0.93148612 |
| 62 | MP0002876_abnormal_thyroid_physiology | 0.90039253 |
| 63 | MP0003448_altered_tumor_morphology | 0.89731022 |
| 64 | MP0005379_endocrine/exocrine_gland_phen | 0.88375532 |
| 65 | MP0003077_abnormal_cell_cycle | 0.86992587 |
| 66 | MP0001849_ear_inflammation | 0.86913925 |
| 67 | MP0008057_abnormal_DNA_replication | 0.86699585 |
| 68 | MP0005075_abnormal_melanosome_morpholog | 0.84449195 |
| 69 | MP0001919_abnormal_reproductive_system | 0.83491552 |
| 70 | MP0003303_peritoneal_inflammation | 0.83444858 |
| 71 | MP0000465_gastrointestinal_hemorrhage | 0.80992132 |
| 72 | MP0002693_abnormal_pancreas_physiology | 0.77596006 |
| 73 | MP0002998_abnormal_bone_remodeling | 0.75929927 |
| 74 | MP0004957_abnormal_blastocyst_morpholog | 0.75307603 |
| 75 | MP0002138_abnormal_hepatobiliary_system | 0.75255784 |
| 76 | MP0003646_muscle_fatigue | 0.74980598 |
| 77 | MP0003111_abnormal_nucleus_morphology | 0.72555554 |
| 78 | MP0001243_abnormal_dermal_layer | 0.71541116 |
| 79 | MP0003693_abnormal_embryo_hatching | 0.71521792 |
| 80 | MP0001348_abnormal_lacrimal_gland | 0.71044346 |
| 81 | MP0001346_abnormal_lacrimal_gland | 0.67624837 |
| 82 | MP0001533_abnormal_skeleton_physiology | 0.66420238 |
| 83 | MP0005166_decreased_susceptibility_to | 0.66327337 |
| 84 | MP0005377_hearing/vestibular/ear_phenot | 0.64529845 |
| 85 | MP0003878_abnormal_ear_physiology | 0.64529845 |
| 86 | MP0000477_abnormal_intestine_morphology | 0.62671645 |
| 87 | MP0003183_abnormal_peptide_metabolism | 0.61296093 |
| 88 | MP0001191_abnormal_skin_condition | 0.60718860 |
| 89 | MP0002163_abnormal_gland_morphology | 0.60613399 |
| 90 | MP0008961_abnormal_basal_metabolism | 0.57324075 |
| 91 | MP0005023_abnormal_wound_healing | 0.57260997 |
| 92 | MP0001765_abnormal_ion_homeostasis | 0.56808405 |
| 93 | MP0003191_abnormal_cellular_cholesterol | 0.55200560 |
| 94 | MP0000609_abnormal_liver_physiology | 0.54057910 |
| 95 | MP0005076_abnormal_cell_differentiation | 0.53596948 |
| 96 | MP0009763_increased_sensitivity_to | 0.53451465 |
| 97 | MP0008872_abnormal_physiological_respon | 0.53136234 |
| 98 | MP0008877_abnormal_DNA_methylation | 0.51604041 |
| 99 | MP0005390_skeleton_phenotype | 0.50226981 |
| 100 | MP0010234_abnormal_vibrissa_follicle | 0.50162930 |
| 101 | MP0003786_premature_aging | 0.49448343 |
| 102 | MP0000383_abnormal_hair_follicle | 0.49317439 |
| 103 | MP0004130_abnormal_muscle_cell | 0.49165558 |
| 104 | MP0008007_abnormal_cellular_replicative | 0.49081193 |
| 105 | MP0000313_abnormal_cell_death | 0.47001119 |
| 106 | MP0001986_abnormal_taste_sensitivity | 0.46837120 |
| 107 | MP0003795_abnormal_bone_structure | 0.46277678 |
| 108 | MP0008569_lethality_at_weaning | 0.46251324 |
| 109 | MP0008770_decreased_survivor_rate | 0.46050000 |
| 110 | MP0000604_amyloidosis | 0.45975688 |
| 111 | MP0001501_abnormal_sleep_pattern | 0.45617702 |
| 112 | MP0009765_abnormal_xenobiotic_induced | 0.45431664 |
| 113 | MP0002083_premature_death | 0.43310437 |
| 114 | MP0000920_abnormal_myelination | 0.43081837 |
| 115 | MP0005645_abnormal_hypothalamus_physiol | 0.42845394 |
| 116 | MP0002822_catalepsy | 0.42425837 |
| 117 | MP0009643_abnormal_urine_homeostasis | 0.41944120 |
| 118 | MP0009764_decreased_sensitivity_to | 0.40893999 |
| 119 | MP0001663_abnormal_digestive_system | 0.40644365 |
| 120 | MP0008058_abnormal_DNA_repair | 0.40506042 |
| 121 | MP0003252_abnormal_bile_duct | 0.40420013 |
| 122 | MP0002877_abnormal_melanocyte_morpholog | 0.39821086 |
| 123 | MP0002075_abnormal_coat/hair_pigmentati | 0.39716809 |
| 124 | MP0005451_abnormal_body_composition | 0.39510715 |
| 125 | MP0008873_increased_physiological_sensi | 0.39452011 |
| 126 | MP0000367_abnormal_coat/_hair | 0.37374481 |
| 127 | MP0004742_abnormal_vestibular_system | 0.36860706 |
| 128 | MP0003172_abnormal_lysosome_physiology | 0.36814435 |
| 129 | MP0000249_abnormal_blood_vessel | 0.36398141 |
| 130 | MP0003959_abnormal_lean_body | 0.35483191 |
| 131 | MP0000350_abnormal_cell_proliferation | 0.35188840 |
| 132 | MP0002136_abnormal_kidney_physiology | 0.34704219 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Severe combined immunodeficiency (HP:0004430) | 8.99960010 |
| 2 | Combined immunodeficiency (HP:0005387) | 8.07499546 |
| 3 | B lymphocytopenia (HP:0010976) | 7.62810297 |
| 4 | Abnormality of B cell number (HP:0010975) | 7.62810297 |
| 5 | Hypoplasia of the thymus (HP:0000778) | 7.34952039 |
| 6 | Thyroiditis (HP:0100646) | 7.27547205 |
| 7 | Abnormality of T cells (HP:0002843) | 6.49227179 |
| 8 | Panhypogammaglobulinemia (HP:0003139) | 6.44107172 |
| 9 | Eosinophilia (HP:0001880) | 6.10148722 |
| 10 | Abnormality of eosinophils (HP:0001879) | 5.82072759 |
| 11 | Recurrent viral infections (HP:0004429) | 5.62509121 |
| 12 | IgG deficiency (HP:0004315) | 5.51046850 |
| 13 | Granulocytopenia (HP:0001913) | 5.15803445 |
| 14 | Elevated erythrocyte sedimentation rate (HP:0003565) | 5.04324575 |
| 15 | Recurrent fungal infections (HP:0002841) | 4.75033941 |
| 16 | Hypoproteinemia (HP:0003075) | 4.65348870 |
| 17 | Leukocytosis (HP:0001974) | 4.47122736 |
| 18 | Recurrent bronchitis (HP:0002837) | 4.07288298 |
| 19 | Increased IgM level (HP:0003496) | 3.96432332 |
| 20 | Autoimmune hemolytic anemia (HP:0001890) | 3.76577212 |
| 21 | Chronic mucocutaneous candidiasis (HP:0002728) | 3.62807414 |
| 22 | Recurrent cutaneous fungal infections (HP:0011370) | 3.62807414 |
| 23 | IgM deficiency (HP:0002850) | 3.39564163 |
| 24 | Abnormality of the fingertips (HP:0001211) | 3.35551226 |
| 25 | Chronic diarrhea (HP:0002028) | 3.24399017 |
| 26 | Abnormality of macrophages (HP:0004311) | 3.20806609 |
| 27 | Stomatitis (HP:0010280) | 3.20341672 |
| 28 | Pustule (HP:0200039) | 3.13739274 |
| 29 | Recurrent bacterial skin infections (HP:0005406) | 3.10729883 |
| 30 | Chronic otitis media (HP:0000389) | 2.95801046 |
| 31 | Myositis (HP:0100614) | 2.93880447 |
| 32 | Lymphopenia (HP:0001888) | 2.93058928 |
| 33 | Abnormality of T cell physiology (HP:0011840) | 2.89243298 |
| 34 | Aplasia/Hypoplasia of the thymus (HP:0010515) | 2.89107956 |
| 35 | Lymphoma (HP:0002665) | 2.87384982 |
| 36 | Abnormality of cells of the lymphoid lineage (HP:0012140) | 2.84831808 |
| 37 | Nasal polyposis (HP:0100582) | 2.82874408 |
| 38 | Joint swelling (HP:0001386) | 2.81537741 |
| 39 | Aplastic anemia (HP:0001915) | 2.78947315 |
| 40 | Meningitis (HP:0001287) | 2.68216324 |
| 41 | Acute hepatic failure (HP:0006554) | 2.60570016 |
| 42 | Abnormal delayed hypersensitivity skin test (HP:0002963) | 2.60511081 |
| 43 | Chest pain (HP:0100749) | 2.55646035 |
| 44 | Hypochromic anemia (HP:0001931) | 2.53785233 |
| 45 | Eczematoid dermatitis (HP:0000976) | 2.45352195 |
| 46 | Hypergammaglobulinemia (HP:0010702) | 2.44479295 |
| 47 | Gangrene (HP:0100758) | 2.43525156 |
| 48 | Basal cell carcinoma (HP:0002671) | 2.41966841 |
| 49 | Abnormality of the nasal mucosa (HP:0000433) | 2.36822597 |
| 50 | Erythroderma (HP:0001019) | 2.31293681 |
| 51 | Abnormality of the thymus (HP:0000777) | 2.30947516 |
| 52 | Bronchitis (HP:0012387) | 2.28554649 |
| 53 | Abnormality of the pleura (HP:0002103) | 2.16424113 |
| 54 | Encephalitis (HP:0002383) | 2.16389496 |
| 55 | Recurrent otitis media (HP:0000403) | 2.11281220 |
| 56 | Keratitis (HP:0000491) | 2.10787864 |
| 57 | Cellular immunodeficiency (HP:0005374) | 2.07176351 |
| 58 | Verrucae (HP:0200043) | 2.06679461 |
| 59 | Papilloma (HP:0012740) | 2.06679461 |
| 60 | Anorexia (HP:0002039) | 2.06414524 |
| 61 | Autoimmune thrombocytopenia (HP:0001973) | 2.05631530 |
| 62 | Arterial thrombosis (HP:0004420) | 2.04994276 |
| 63 | Urticaria (HP:0001025) | 2.03497083 |
| 64 | IgA deficiency (HP:0002720) | 2.02299845 |
| 65 | Recurrent gram-negative bacterial infections (HP:0005420) | 2.00337887 |
| 66 | T lymphocytopenia (HP:0005403) | 10.9198825 |
| 67 | Abnormality of T cell number (HP:0011839) | 10.3938916 |
| 68 | Reduced subcutaneous adipose tissue (HP:0003758) | 1.97445755 |
| 69 | Stomach cancer (HP:0012126) | 1.93298749 |
| 70 | Recurrent skin infections (HP:0001581) | 1.92266071 |
| 71 | Hemoptysis (HP:0002105) | 1.89782113 |
| 72 | Vasculitis (HP:0002633) | 1.89637976 |
| 73 | Hemiplegia (HP:0002301) | 1.88690222 |
| 74 | Orchitis (HP:0100796) | 1.88524391 |
| 75 | Pancytopenia (HP:0001876) | 1.85030642 |
| 76 | Agammaglobulinemia (HP:0004432) | 1.84515108 |
| 77 | Papilledema (HP:0001085) | 1.82938024 |
| 78 | Skin rash (HP:0000988) | 1.80829847 |
| 79 | Neutropenia (HP:0001875) | 1.80167724 |
| 80 | Poikiloderma (HP:0001029) | 1.79381990 |
| 81 | Bronchiectasis (HP:0002110) | 1.79192051 |
| 82 | Episodic fever (HP:0001954) | 1.79090751 |
| 83 | Optic neuritis (HP:0100653) | 1.78209554 |
| 84 | Retrobulbar optic neuritis (HP:0100654) | 1.78209554 |
| 85 | Spontaneous hematomas (HP:0007420) | 1.78039998 |
| 86 | Recurrent sinusitis (HP:0011108) | 1.77635914 |
| 87 | Glomerulopathy (HP:0100820) | 1.76055918 |
| 88 | Bicuspid aortic valve (HP:0001647) | 1.73532380 |
| 89 | Sepsis (HP:0100806) | 1.73248866 |
| 90 | Pulmonary infiltrates (HP:0002113) | 1.72666943 |
| 91 | Polyneuropathy (HP:0001271) | 1.72136960 |
| 92 | Gingivitis (HP:0000230) | 1.72055270 |
| 93 | Entropion (HP:0000621) | 1.70869387 |
| 94 | Prostate neoplasm (HP:0100787) | 1.70438979 |
| 95 | Pulmonary fibrosis (HP:0002206) | 1.69255995 |
| 96 | Gastrointestinal infarctions (HP:0005244) | 1.68498398 |
| 97 | Petechiae (HP:0000967) | 1.67842434 |
| 98 | Gastrointestinal stroma tumor (HP:0100723) | 1.67284647 |
| 99 | Amyotrophic lateral sclerosis (HP:0007354) | 1.62574354 |
| 100 | Microcytic anemia (HP:0001935) | 1.59770164 |
| 101 | Volvulus (HP:0002580) | 1.56874008 |
| 102 | Keratoconjunctivitis sicca (HP:0001097) | 1.53301966 |
| 103 | Epistaxis (HP:0000421) | 1.51613592 |
| 104 | Cheilitis (HP:0100825) | 1.50988817 |
| 105 | Hepatitis (HP:0012115) | 1.50861572 |
| 106 | Increased IgE level (HP:0003212) | 1.45349389 |
| 107 | Chronic sinusitis (HP:0011109) | 1.45240753 |
| 108 | Gastrointestinal inflammation (HP:0004386) | 1.42704932 |
| 109 | Muscle fiber atrophy (HP:0100295) | 1.42696267 |
| 110 | Inflammation of the large intestine (HP:0002037) | 1.40475292 |
| 111 | Seborrheic dermatitis (HP:0001051) | 1.40050823 |
| 112 | Chronic obstructive pulmonary disease (HP:0006510) | 1.39660198 |
| 113 | Obstructive lung disease (HP:0006536) | 1.39660198 |
| 114 | Abnormality of the prostate (HP:0008775) | 1.39257284 |
| 115 | Abnormal platelet volume (HP:0011876) | 1.38957490 |
| 116 | Subacute progressive viral hepatitis (HP:0006572) | 1.37993897 |
| 117 | Keratoconjunctivitis (HP:0001096) | 1.36742503 |
| 118 | Recurrent abscess formation (HP:0002722) | 1.36704830 |
| 119 | Type 2 muscle fiber atrophy (HP:0003554) | 1.36080875 |
| 120 | Thrombocytosis (HP:0001894) | 1.35589444 |
| 121 | Pruritus (HP:0000989) | 1.35517277 |
| 122 | Large eyes (HP:0001090) | 1.35212006 |
| 123 | Prominent nose (HP:0000448) | 1.35115709 |
| 124 | Ureteral stenosis (HP:0000071) | 1.34464095 |
| 125 | Mediastinal lymphadenopathy (HP:0100721) | 1.33805680 |
| 126 | Pulmonary embolism (HP:0002204) | 1.33292597 |
| 127 | Prolonged bleeding time (HP:0003010) | 1.29457552 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | TXK | 6.84907759 |
| 2 | MAP4K1 | 5.53696354 |
| 3 | ZAP70 | 4.02841617 |
| 4 | TESK2 | 3.07456403 |
| 5 | ITK | 3.02448857 |
| 6 | FGFR4 | 2.99376150 |
| 7 | KDR | 2.55974117 |
| 8 | GRK6 | 2.41559986 |
| 9 | IKBKE | 2.33619419 |
| 10 | TAOK3 | 2.29396904 |
| 11 | STK10 | 2.24723705 |
| 12 | JAK3 | 2.24022263 |
| 13 | TYK2 | 2.23648034 |
| 14 | LCK | 2.08475169 |
| 15 | RIPK4 | 2.08023780 |
| 16 | SYK | 2.07937671 |
| 17 | MST4 | 1.91169347 |
| 18 | JAK1 | 1.89498955 |
| 19 | FGFR3 | 1.87054858 |
| 20 | CSK | 1.78090308 |
| 21 | MAP3K11 | 1.77677723 |
| 22 | NLK | 1.76160930 |
| 23 | NME2 | 1.56251415 |
| 24 | HCK | 1.55515354 |
| 25 | PDGFRB | 1.50334471 |
| 26 | TEC | 1.48851500 |
| 27 | CAMKK1 | 1.46272891 |
| 28 | BTK | 1.33081440 |
| 29 | TBK1 | 1.27636035 |
| 30 | PRKCQ | 1.26451831 |
| 31 | MAP3K7 | 1.25721427 |
| 32 | MAP3K10 | 1.17709727 |
| 33 | SIK2 | 1.14044002 |
| 34 | TESK1 | 1.13765057 |
| 35 | CDC7 | 1.11330071 |
| 36 | MAP3K14 | 1.03658428 |
| 37 | PRKCH | 1.02849135 |
| 38 | MAP3K12 | 0.99397703 |
| 39 | CLK1 | 0.98853167 |
| 40 | PKN2 | 0.98640443 |
| 41 | BLK | 0.98111937 |
| 42 | EEF2K | 0.97379732 |
| 43 | LRRK2 | 0.89912263 |
| 44 | TNK2 | 0.83821135 |
| 45 | CDK12 | 0.83474465 |
| 46 | PRPF4B | 0.83108780 |
| 47 | YES1 | 0.81157114 |
| 48 | MAPK7 | 0.79781093 |
| 49 | ADRBK2 | 0.77938492 |
| 50 | MAP3K13 | 0.77237207 |
| 51 | GRK7 | 0.77207010 |
| 52 | MUSK | 0.76525943 |
| 53 | LYN | 0.75991812 |
| 54 | MARK2 | 0.75379341 |
| 55 | JAK2 | 0.74435836 |
| 56 | INSR | 0.73884969 |
| 57 | BUB1 | 0.73185748 |
| 58 | FYN | 0.70049250 |
| 59 | KIT | 0.67876734 |
| 60 | STK4 | 0.65991684 |
| 61 | FGFR2 | 0.65463495 |
| 62 | CDK4 | 0.65161875 |
| 63 | MAP4K2 | 0.64255686 |
| 64 | TGFBR2 | 0.63959209 |
| 65 | MAP3K3 | 0.63621071 |
| 66 | TAOK2 | 0.63608564 |
| 67 | MARK3 | 0.62740215 |
| 68 | PIK3CG | 0.61866596 |
| 69 | ERN1 | 0.61569946 |
| 70 | BCR | 0.59044796 |
| 71 | MAP2K3 | 0.58846591 |
| 72 | PIM1 | 0.58661678 |
| 73 | SIK3 | 0.58301109 |
| 74 | TAOK1 | 0.56493665 |
| 75 | EIF2AK1 | 0.55309243 |
| 76 | FGFR1 | 0.55064273 |
| 77 | CDK6 | 0.53073826 |
| 78 | RPS6KA4 | 0.51820927 |
| 79 | TYRO3 | 0.50000009 |
| 80 | NUAK1 | 0.49636782 |
| 81 | HIPK2 | 0.48998709 |
| 82 | MAPK11 | 0.46365266 |
| 83 | NEK2 | 0.46190428 |
| 84 | IKBKB | 0.45792730 |
| 85 | CSF1R | 0.43966279 |
| 86 | BMPR2 | 0.43963137 |
| 87 | EPHA3 | 0.42265768 |
| 88 | MAPKAPK2 | 0.42140838 |
| 89 | MAPK4 | 0.42120958 |
| 90 | SCYL2 | 0.41501222 |
| 91 | FES | 0.41237695 |
| 92 | MAP2K2 | 0.39699529 |
| 93 | LIMK1 | 0.38009432 |
| 94 | TRIB3 | 0.38001709 |
| 95 | RPS6KB2 | 0.37260682 |
| 96 | ATR | 0.36308177 |
| 97 | PDK1 | 0.35257117 |
| 98 | EPHB1 | 0.33901898 |
| 99 | TLK1 | 0.32923160 |
| 100 | MAPK12 | 0.32898467 |
| 101 | MAP3K1 | 0.32567737 |
| 102 | CDK9 | 0.32514607 |
| 103 | IGF1R | 0.32415481 |
| 104 | BRD4 | 0.32123191 |
| 105 | CSNK1A1L | 0.32063870 |
| 106 | CHUK | 0.31849331 |
| 107 | PRKD2 | 0.31440014 |
| 108 | MAPK3 | 0.31353283 |
| 109 | SIK1 | 0.30243254 |
| 110 | RPS6KA5 | 0.27848312 |
| 111 | BCKDK | 0.26330046 |
| 112 | EIF2AK3 | 0.25759774 |
| 113 | IRAK4 | 0.25308965 |
| 114 | NTRK2 | 0.25188807 |
| 115 | ALK | 0.24979031 |
| 116 | AURKB | 0.24148271 |
| 117 | PRKD1 | 0.24021918 |
| 118 | SRC | 0.23295521 |
| 119 | ZAK | 0.23143858 |
| 120 | PTK6 | 0.22709192 |
| 121 | PASK | 0.22684132 |
| 122 | MELK | 0.21939842 |
| 123 | SRPK1 | 0.20767071 |
| 124 | MAP2K6 | 0.20367738 |
| 125 | CAMKK2 | 0.20348946 |
| 126 | PRKCD | 0.19492243 |
| 127 | MATK | 0.16924705 |
| 128 | NEK6 | 0.16331134 |
| 129 | FGR | 0.14561377 |
| 130 | SMG1 | 0.11570341 |
| 131 | VRK1 | 0.10870174 |
| 132 | MAPKAPK3 | 0.10644992 |
| 133 | WNK4 | 0.09601461 |
| 134 | DAPK1 | 0.09159437 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Primary immunodeficiency_Homo sapiens_hsa05340 | 8.14963926 |
| 2 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 4.61841565 |
| 3 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 3.18494507 |
| 4 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 3.14562465 |
| 5 | Antigen processing and presentation_Homo sapiens_hsa04612 | 2.98662301 |
| 6 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 2.86267222 |
| 7 | Measles_Homo sapiens_hsa05162 | 2.68669410 |
| 8 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 2.67368829 |
| 9 | Non-homologous end-joining_Homo sapiens_hsa03450 | 2.66188315 |
| 10 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 2.22560461 |
| 11 | Allograft rejection_Homo sapiens_hsa05330 | 2.12555170 |
| 12 | Graft-versus-host disease_Homo sapiens_hsa05332 | 2.06780345 |
| 13 | Viral myocarditis_Homo sapiens_hsa05416 | 1.74504120 |
| 14 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 1.69547078 |
| 15 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 1.39029812 |
| 16 | Herpes simplex infection_Homo sapiens_hsa05168 | 1.38504684 |
| 17 | Osteoclast differentiation_Homo sapiens_hsa04380 | 1.37793467 |
| 18 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 1.34523004 |
| 19 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 1.34002992 |
| 20 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 1.33586732 |
| 21 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 1.32282545 |
| 22 | Leishmaniasis_Homo sapiens_hsa05140 | 1.32214226 |
| 23 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.29963924 |
| 24 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 1.23768478 |
| 25 | Spliceosome_Homo sapiens_hsa03040 | 1.22877469 |
| 26 | HTLV-I infection_Homo sapiens_hsa05166 | 1.21932243 |
| 27 | Ribosome_Homo sapiens_hsa03010 | 1.19184583 |
| 28 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 1.17126510 |
| 29 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 1.15561396 |
| 30 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 1.15372071 |
| 31 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 1.14792213 |
| 32 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 1.14070308 |
| 33 | DNA replication_Homo sapiens_hsa03030 | 1.12727876 |
| 34 | Hepatitis B_Homo sapiens_hsa05161 | 1.11553176 |
| 35 | Colorectal cancer_Homo sapiens_hsa05210 | 1.05361707 |
| 36 | Thyroid cancer_Homo sapiens_hsa05216 | 1.01239081 |
| 37 | Toxoplasmosis_Homo sapiens_hsa05145 | 0.93988005 |
| 38 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.93680803 |
| 39 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.87849159 |
| 40 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.85855762 |
| 41 | Shigellosis_Homo sapiens_hsa05131 | 0.85683952 |
| 42 | Mismatch repair_Homo sapiens_hsa03430 | 0.85048701 |
| 43 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.84098020 |
| 44 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.79865910 |
| 45 | Proteasome_Homo sapiens_hsa03050 | 0.78549980 |
| 46 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.78243149 |
| 47 | Influenza A_Homo sapiens_hsa05164 | 0.76539465 |
| 48 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.75691445 |
| 49 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.73488643 |
| 50 | Apoptosis_Homo sapiens_hsa04210 | 0.73366137 |
| 51 | Asthma_Homo sapiens_hsa05310 | 0.69157375 |
| 52 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.67828061 |
| 53 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 0.66250219 |
| 54 | Base excision repair_Homo sapiens_hsa03410 | 0.64821756 |
| 55 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.63400727 |
| 56 | Cell cycle_Homo sapiens_hsa04110 | 0.63110533 |
| 57 | RNA degradation_Homo sapiens_hsa03018 | 0.61622566 |
| 58 | Platelet activation_Homo sapiens_hsa04611 | 0.61081688 |
| 59 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.60952574 |
| 60 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.60089746 |
| 61 | Nucleotide excision repair_Homo sapiens_hsa03420 | 0.59623430 |
| 62 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 0.58112773 |
| 63 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.56637401 |
| 64 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.56624690 |
| 65 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.52823245 |
| 66 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.52055951 |
| 67 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 0.51805689 |
| 68 | Hepatitis C_Homo sapiens_hsa05160 | 0.50517381 |
| 69 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.50143779 |
| 70 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.49324417 |
| 71 | Sulfur relay system_Homo sapiens_hsa04122 | 0.49084256 |
| 72 | Legionellosis_Homo sapiens_hsa05134 | 0.48554764 |
| 73 | TNF signaling pathway_Homo sapiens_hsa04668 | 0.48539809 |
| 74 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.47448429 |
| 75 | Salmonella infection_Homo sapiens_hsa05132 | 0.46200613 |
| 76 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.46199649 |
| 77 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.46137196 |
| 78 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.45791824 |
| 79 | Endometrial cancer_Homo sapiens_hsa05213 | 0.44826488 |
| 80 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.44410617 |
| 81 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.39540271 |
| 82 | Phototransduction_Homo sapiens_hsa04744 | 0.37521430 |
| 83 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.37495455 |
| 84 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.37363839 |
| 85 | Endocytosis_Homo sapiens_hsa04144 | 0.37217578 |
| 86 | RNA transport_Homo sapiens_hsa03013 | 0.36343699 |
| 87 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.35571931 |
| 88 | Adherens junction_Homo sapiens_hsa04520 | 0.35172192 |
| 89 | Tuberculosis_Homo sapiens_hsa05152 | 0.34747333 |
| 90 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.34161533 |
| 91 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.34016933 |
| 92 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.33246163 |
| 93 | Malaria_Homo sapiens_hsa05144 | 0.32116399 |
| 94 | Prostate cancer_Homo sapiens_hsa05215 | 0.31789538 |
| 95 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.30136001 |
| 96 | Pertussis_Homo sapiens_hsa05133 | 0.27840357 |
| 97 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.27229005 |
| 98 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.26557785 |
| 99 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.23979845 |
| 100 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.23908670 |
| 101 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.22973343 |
| 102 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.22587847 |
| 103 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.21965298 |
| 104 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 0.21712122 |
| 105 | Homologous recombination_Homo sapiens_hsa03440 | 0.21045886 |
| 106 | Prion diseases_Homo sapiens_hsa05020 | 0.20275802 |
| 107 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.19969993 |
| 108 | Pathways in cancer_Homo sapiens_hsa05200 | 0.19691317 |
| 109 | Phagosome_Homo sapiens_hsa04145 | 0.18443985 |
| 110 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.17102114 |
| 111 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.17065113 |
| 112 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.15956657 |
| 113 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.15241287 |
| 114 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.15057702 |
| 115 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.14831301 |
| 116 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.14728603 |
| 117 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.13346697 |
| 118 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.13304076 |
| 119 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.12991308 |
| 120 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.12784487 |
| 121 | Lysine degradation_Homo sapiens_hsa00310 | 0.12665431 |
| 122 | Insulin resistance_Homo sapiens_hsa04931 | 0.11477709 |
| 123 | RNA polymerase_Homo sapiens_hsa03020 | 0.11353915 |
| 124 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.09996077 |
| 125 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.06408398 |
| 126 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.05889303 |
| 127 | ABC transporters_Homo sapiens_hsa02010 | 0.05851399 |
| 128 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.05217015 |
| 129 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.04839605 |
| 130 | Olfactory transduction_Homo sapiens_hsa04740 | 0.03772507 |

