

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | negative T cell selection (GO:0043383) | 9.51305990 |
| 2 | negative thymic T cell selection (GO:0045060) | 8.66355810 |
| 3 | positive regulation of gamma-delta T cell activation (GO:0046645) | 8.39665075 |
| 4 | cytidine metabolic process (GO:0046087) | 7.81824240 |
| 5 | cytidine catabolic process (GO:0006216) | 7.81824240 |
| 6 | cytidine deamination (GO:0009972) | 7.81824240 |
| 7 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 7.61759962 |
| 8 | regulation of T cell tolerance induction (GO:0002664) | 7.53764454 |
| 9 | negative regulation of cell killing (GO:0031342) | 7.23512718 |
| 10 | negative regulation of leukocyte mediated cytotoxicity (GO:0001911) | 7.23512718 |
| 11 | positive regulation of antigen receptor-mediated signaling pathway (GO:0050857) | 7.18237952 |
| 12 | interferon-gamma production (GO:0032609) | 7.08092331 |
| 13 | thymic T cell selection (GO:0045061) | 7.06801553 |
| 14 | positive T cell selection (GO:0043368) | 7.06043437 |
| 15 | pyrimidine ribonucleoside catabolic process (GO:0046133) | 6.97808643 |
| 16 | regulation of gamma-delta T cell differentiation (GO:0045586) | 6.84318206 |
| 17 | T cell selection (GO:0045058) | 6.76755044 |
| 18 | positive regulation of interleukin-2 biosynthetic process (GO:0045086) | 6.57944215 |
| 19 | antigen processing and presentation of endogenous peptide antigen (GO:0002483) | 6.56632726 |
| 20 | antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885) | 6.56632726 |
| 21 | regulation of isotype switching to IgG isotypes (GO:0048302) | 6.47694416 |
| 22 | positive thymic T cell selection (GO:0045059) | 6.46108128 |
| 23 | positive regulation of tolerance induction (GO:0002645) | 6.17312683 |
| 24 | actin nucleation (GO:0045010) | 6.14003753 |
| 25 | negative regulation by host of viral transcription (GO:0043922) | 6.12461121 |
| 26 | regulation of gamma-delta T cell activation (GO:0046643) | 6.12253946 |
| 27 | T cell receptor signaling pathway (GO:0050852) | 6.06488513 |
| 28 | response to interleukin-15 (GO:0070672) | 5.79902937 |
| 29 | cellular response to interleukin-15 (GO:0071350) | 5.76833453 |
| 30 | T cell migration (GO:0072678) | 5.76542250 |
| 31 | DNA deamination (GO:0045006) | 5.74027045 |
| 32 | positive regulation of alpha-beta T cell proliferation (GO:0046641) | 5.55209065 |
| 33 | T cell costimulation (GO:0031295) | 5.50640521 |
| 34 | antigen processing and presentation of endogenous antigen (GO:0019883) | 5.45840159 |
| 35 | regulation of alpha-beta T cell proliferation (GO:0046640) | 5.44322008 |
| 36 | regulation of tolerance induction (GO:0002643) | 5.41126787 |
| 37 | lymphocyte costimulation (GO:0031294) | 5.40780325 |
| 38 | negative regulation of T cell apoptotic process (GO:0070233) | 5.33434627 |
| 39 | leukocyte aggregation (GO:0070486) | 5.21493066 |
| 40 | antigen receptor-mediated signaling pathway (GO:0050851) | 5.07133017 |
| 41 | eosinophil chemotaxis (GO:0048245) | 5.05628366 |
| 42 | activated T cell proliferation (GO:0050798) | 4.91469409 |
| 43 | regulation of natural killer cell mediated immunity (GO:0002715) | 4.85503448 |
| 44 | regulation of natural killer cell mediated cytotoxicity (GO:0042269) | 4.85503448 |
| 45 | regulation of activation of Janus kinase activity (GO:0010533) | 4.81046717 |
| 46 | regulation of lymphocyte chemotaxis (GO:1901623) | 4.80385952 |
| 47 | regulation of T cell receptor signaling pathway (GO:0050856) | 4.78066726 |
| 48 | mast cell activation (GO:0045576) | 4.77184959 |
| 49 | signal complex assembly (GO:0007172) | 4.77028711 |
| 50 | positive regulation of T cell chemotaxis (GO:0010820) | 4.75969552 |
| 51 | regulation of T cell chemotaxis (GO:0010819) | 4.75969552 |
| 52 | regulation of interleukin-2 biosynthetic process (GO:0045076) | 4.70092823 |
| 53 | positive regulation of natural killer cell mediated immunity (GO:0002717) | 4.67306944 |
| 54 | positive regulation of natural killer cell mediated cytotoxicity (GO:0045954) | 4.67306944 |
| 55 | regulation of antigen receptor-mediated signaling pathway (GO:0050854) | 4.63225320 |
| 56 | negative regulation of B cell proliferation (GO:0030889) | 4.60612151 |
| 57 | regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923) | 4.57803576 |
| 58 | eosinophil migration (GO:0072677) | 4.56494167 |
| 59 | regulation of chronic inflammatory response (GO:0002676) | 4.50594750 |
| 60 | regulation of B cell receptor signaling pathway (GO:0050855) | 4.48607861 |
| 61 | positive regulation of interleukin-2 production (GO:0032743) | 4.24135217 |
| 62 | positive regulation of monocyte chemotaxis (GO:0090026) | 4.23780558 |
| 63 | monocyte chemotaxis (GO:0002548) | 4.16511822 |
| 64 | ribosomal small subunit assembly (GO:0000028) | 4.14575633 |
| 65 | positive regulation of B cell mediated immunity (GO:0002714) | 4.10077888 |
| 66 | positive regulation of immunoglobulin mediated immune response (GO:0002891) | 4.10077888 |
| 67 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G | 4.09743892 |
| 68 | negative regulation of T cell mediated immunity (GO:0002710) | 4.07735142 |
| 69 | regulation of regulatory T cell differentiation (GO:0045589) | 4.07362909 |
| 70 | positive regulation of B cell differentiation (GO:0045579) | 4.06686645 |
| 71 | positive regulation of isotype switching (GO:0045830) | 4.05001603 |
| 72 | V(D)J recombination (GO:0033151) | 4.02014193 |
| 73 | positive regulation of lymphocyte migration (GO:2000403) | 3.98378941 |
| 74 | positive regulation of humoral immune response (GO:0002922) | 3.96689803 |
| 75 | regulation of leukocyte mediated cytotoxicity (GO:0001910) | 3.95002482 |
| 76 | regulation of response to tumor cell (GO:0002834) | 3.94818835 |
| 77 | positive regulation of response to tumor cell (GO:0002836) | 3.94818835 |
| 78 | positive regulation of immune response to tumor cell (GO:0002839) | 3.94818835 |
| 79 | regulation of immune response to tumor cell (GO:0002837) | 3.94818835 |
| 80 | positive regulation of leukocyte mediated cytotoxicity (GO:0001912) | 3.90014040 |
| 81 | sequestering of actin monomers (GO:0042989) | 3.85815753 |
| 82 | T cell differentiation (GO:0030217) | 3.83904264 |
| 83 | macrophage chemotaxis (GO:0048246) | 3.79910104 |
| 84 | regulation of T cell apoptotic process (GO:0070232) | 3.79390110 |
| 85 | natural killer cell differentiation (GO:0001779) | 3.77673087 |
| 86 | positive regulation of T cell apoptotic process (GO:0070234) | 3.76317606 |
| 87 | positive regulation of macrophage differentiation (GO:0045651) | 3.73660721 |
| 88 | cellular response to interleukin-4 (GO:0071353) | 3.72805667 |
| 89 | regulation of immunoglobulin mediated immune response (GO:0002889) | 3.71751973 |
| 90 | negative regulation of viral transcription (GO:0032897) | 3.70817769 |
| 91 | negative regulation of T cell receptor signaling pathway (GO:0050860) | 3.68512334 |
| 92 | T cell activation (GO:0042110) | 3.65821961 |
| 93 | regulation of isotype switching (GO:0045191) | 3.65424827 |
| 94 | regulation of cell killing (GO:0031341) | 3.64873581 |
| 95 | regulation of mononuclear cell migration (GO:0071675) | 3.62405643 |
| 96 | positive regulation of cell killing (GO:0031343) | 3.61727183 |
| 97 | alpha-beta T cell differentiation (GO:0046632) | 3.61688736 |
| 98 | regulation of ruffle assembly (GO:1900027) | 3.61621282 |
| 99 | antigen processing and presentation via MHC class Ib (GO:0002475) | 3.60915520 |
| 100 | regulation of B cell mediated immunity (GO:0002712) | 3.60382576 |
| 101 | negative regulation of alpha-beta T cell activation (GO:0046636) | 3.60378661 |
| 102 | regulation of chemokine-mediated signaling pathway (GO:0070099) | 3.59271566 |
| 103 | mast cell degranulation (GO:0043303) | 3.58828343 |
| 104 | mast cell activation involved in immune response (GO:0002279) | 3.58828343 |
| 105 | negative regulation of viral genome replication (GO:0045071) | 3.58772120 |
| 106 | alpha-beta T cell activation (GO:0046631) | 3.58584361 |
| 107 | positive regulation of interleukin-4 production (GO:0032753) | 3.58217972 |
| 108 | negative regulation of lymphocyte apoptotic process (GO:0070229) | 3.55560705 |
| 109 | immune response-activating cell surface receptor signaling pathway (GO:0002429) | 3.53887229 |
| 110 | modulation by host of viral transcription (GO:0043921) | 3.53106122 |
| 111 | modulation by host of symbiont transcription (GO:0052472) | 3.53106122 |
| 112 | positive regulation of uterine smooth muscle contraction (GO:0070474) | 3.52808271 |
| 113 | positive regulation of calcium-mediated signaling (GO:0050850) | 3.51741870 |
| 114 | positive regulation of immunoglobulin production (GO:0002639) | 3.49605690 |
| 115 | positive regulation of DNA recombination (GO:0045911) | 3.48777850 |
| 116 | positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523) | 3.48620990 |
| 117 | pyrimidine nucleoside catabolic process (GO:0046135) | 3.48239016 |
| 118 | regulation of macrophage chemotaxis (GO:0010758) | 3.48180658 |
| 119 | negative regulation of antigen receptor-mediated signaling pathway (GO:0050858) | 3.46492050 |
| 120 | lymphocyte migration (GO:0072676) | 3.46438878 |
| 121 | NIK/NF-kappaB signaling (GO:0038061) | 3.46228103 |
| 122 | negative regulation of B cell activation (GO:0050869) | 3.42661098 |
| 123 | regulation of calcium-mediated signaling (GO:0050848) | 3.41811821 |
| 124 | modulation of transcription in other organism involved in symbiotic interaction (GO:0052312) | 3.40637512 |
| 125 | positive regulation of translational initiation (GO:0045948) | 3.39593179 |
| 126 | sperm capacitation (GO:0048240) | 3.39461875 |
| 127 | protein-chromophore linkage (GO:0018298) | 3.37975037 |
| 128 | negative regulation of lymphocyte mediated immunity (GO:0002707) | 3.37316319 |
| 129 | regulation of interleukin-4 production (GO:0032673) | 3.36220746 |
| 130 | leukocyte cell-cell adhesion (GO:0007159) | 3.33323660 |
| 131 | positive regulation of T cell migration (GO:2000406) | 3.32777153 |
| 132 | negative regulation of stress fiber assembly (GO:0051497) | 3.31744894 |
| 133 | T cell homeostasis (GO:0043029) | 3.30949583 |
| 134 | response to interleukin-4 (GO:0070670) | 3.30384138 |
| 135 | regulation of response to interferon-gamma (GO:0060330) | 3.29744446 |
| 136 | regulation of immunoglobulin production (GO:0002637) | 3.29561101 |
| 137 | positive regulation of lamellipodium assembly (GO:0010592) | 3.28328784 |
| 138 | regulation of interleukin-2 production (GO:0032663) | 3.25969657 |
| 139 | regulation of lymphocyte migration (GO:2000401) | 3.25458949 |
| 140 | regulation of interleukin-12 biosynthetic process (GO:0045075) | 3.22460456 |
| 141 | regulation of interferon-gamma-mediated signaling pathway (GO:0060334) | 3.21874361 |
| 142 | cytolysis (GO:0019835) | 3.20282747 |
| 143 | regulation of antigen processing and presentation of peptide antigen (GO:0002583) | 3.19262879 |
| 144 | regulation of T cell migration (GO:2000404) | 3.18479121 |
| 145 | Arp2/3 complex-mediated actin nucleation (GO:0034314) | 3.16774855 |
| 146 | natural killer cell activation (GO:0030101) | 3.16708117 |
| 147 | positive regulation of T cell activation (GO:0050870) | 3.15194413 |
| 148 | regulation of defense response to virus by virus (GO:0050690) | 3.14275434 |
| 149 | multicellular organism reproduction (GO:0032504) | 3.13846946 |
| 150 | positive regulation of T cell cytokine production (GO:0002726) | 3.13421591 |
| 151 | B cell receptor signaling pathway (GO:0050853) | 3.12888978 |
| 152 | T cell proliferation (GO:0042098) | 3.08498163 |
| 153 | positive regulation of lymphocyte mediated immunity (GO:0002708) | 3.08004204 |
| 154 | regulation of B cell differentiation (GO:0045577) | 3.04082388 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 7.94456116 |
| 2 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 6.23031604 |
| 3 | E2F7_22180533_ChIP-Seq_HELA_Human | 5.50139452 |
| 4 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 3.72975089 |
| 5 | RUNX_20019798_ChIP-Seq_JUKART_Human | 3.71309081 |
| 6 | STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 3.65077048 |
| 7 | FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse | 3.54232831 |
| 8 | MYC_22102868_ChIP-Seq_BL_Human | 3.47258947 |
| 9 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 3.42258099 |
| 10 | MYB_26560356_Chip-Seq_TH2_Human | 3.33637392 |
| 11 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 3.32675062 |
| 12 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 3.31075386 |
| 13 | MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 2.94842557 |
| 14 | MAF_26560356_Chip-Seq_TH1_Human | 2.92031173 |
| 15 | UTX_26944678_Chip-Seq_JUKART_Human | 2.80056739 |
| 16 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 2.71015828 |
| 17 | MYB_26560356_Chip-Seq_TH1_Human | 2.60210998 |
| 18 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 2.53626416 |
| 19 | GATA3_27048872_Chip-Seq_THYMUS_Human | 2.31831152 |
| 20 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 2.20549956 |
| 21 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 2.15856878 |
| 22 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 2.12722798 |
| 23 | VDR_21846776_ChIP-Seq_THP-1_Human | 2.08981803 |
| 24 | MAF_26560356_Chip-Seq_TH2_Human | 2.08906065 |
| 25 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 2.08559075 |
| 26 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.00157797 |
| 27 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.99581906 |
| 28 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.96814030 |
| 29 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.92758657 |
| 30 | KDM2B_26808549_Chip-Seq_HPB-ALL_Human | 1.91248876 |
| 31 | RUNX1_22412390_ChIP-Seq_EML_Mouse | 1.89624668 |
| 32 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.89167718 |
| 33 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.87674378 |
| 34 | SPI1_23547873_ChIP-Seq_NB4_Human | 1.86447171 |
| 35 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.78630007 |
| 36 | SCL_19346495_ChIP-Seq_HPC-7_Human | 1.71691429 |
| 37 | E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 1.71690537 |
| 38 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 1.69663483 |
| 39 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 1.69513193 |
| 40 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 1.69024578 |
| 41 | TCF7_22412390_ChIP-Seq_EML_Mouse | 1.66201632 |
| 42 | RUNX1_17652178_ChIP-ChIP_JURKAT_Human | 1.61298349 |
| 43 | SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse | 1.60831050 |
| 44 | CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human | 1.60308189 |
| 45 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.59931752 |
| 46 | VDR_24763502_ChIP-Seq_THP-1_Human | 1.54929206 |
| 47 | NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse | 1.50199506 |
| 48 | MEIS1_20887958_ChIP-Seq_HPC-7_Mouse | 1.48709858 |
| 49 | IRF8_27001747_Chip-Seq_BMDM_Mouse | 1.48393532 |
| 50 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 1.48323577 |
| 51 | BCL6_27268052_Chip-Seq_Bcells_Human | 1.47052556 |
| 52 | KDM2B_26808549_Chip-Seq_DND41_Human | 1.42102140 |
| 53 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 1.41371322 |
| 54 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.36390027 |
| 55 | VDR_23849224_ChIP-Seq_CD4+_Human | 1.34305344 |
| 56 | SPI1_23127762_ChIP-Seq_K562_Human | 1.33526726 |
| 57 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.33343164 |
| 58 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.32718607 |
| 59 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 1.31935256 |
| 60 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.29018087 |
| 61 | BRD4_27068464_Chip-Seq_AML-cells_Mouse | 1.28388058 |
| 62 | GATA3_26560356_Chip-Seq_TH2_Human | 1.27884000 |
| 63 | RBPJ_21746931_ChIP-Seq_IB4-LCL_Human | 1.20399829 |
| 64 | GATA2_22383799_ChIP-Seq_G1ME_Mouse | 1.19703629 |
| 65 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.19224856 |
| 66 | GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.17509663 |
| 67 | ZNF652_21678463_ChIP-ChIP_ZR75-1_Human | 1.17347279 |
| 68 | EGR1_19032775_ChIP-ChIP_M12_Human | 1.16395038 |
| 69 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 1.13606521 |
| 70 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 1.12311511 |
| 71 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.11478190 |
| 72 | BCOR_27268052_Chip-Seq_Bcells_Human | 1.10773120 |
| 73 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.09135418 |
| 74 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.09040516 |
| 75 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 1.06339120 |
| 76 | PU_27001747_Chip-Seq_BMDM_Mouse | 1.04474234 |
| 77 | GATA3_26560356_Chip-Seq_TH1_Human | 1.01807941 |
| 78 | LMO2_20887958_ChIP-Seq_HPC-7_Mouse | 1.01413988 |
| 79 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 1.00383940 |
| 80 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.00020257 |
| 81 | TAF15_26573619_Chip-Seq_HEK293_Human | 0.99549654 |
| 82 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 0.98297636 |
| 83 | SPI1_20517297_ChIP-Seq_HL60_Human | 0.98154890 |
| 84 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 0.97760186 |
| 85 | P300_27268052_Chip-Seq_Bcells_Human | 0.97213039 |
| 86 | TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse | 0.96929854 |
| 87 | RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.96438166 |
| 88 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 0.95345977 |
| 89 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 0.94787577 |
| 90 | SA1_27219007_Chip-Seq_Bcells_Human | 0.94692587 |
| 91 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 0.94638421 |
| 92 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 0.94330259 |
| 93 | PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 0.92709002 |
| 94 | CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse | 0.92344508 |
| 95 | CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 0.90210354 |
| 96 | CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse | 0.90069011 |
| 97 | PBX1_22567123_ChIP-ChIP_OVCAR3_Human | 0.89947676 |
| 98 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 0.89325423 |
| 99 | PU.1_20513432_ChIP-Seq_Bcells_Mouse | 0.88861581 |
| 100 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 0.88510645 |
| 101 | KDM2B_26808549_Chip-Seq_JURKAT_Human | 0.88228048 |
| 102 | XRN2_22483619_ChIP-Seq_HELA_Human | 0.87970607 |
| 103 | TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.87688216 |
| 104 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.87551019 |
| 105 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 0.87422922 |
| 106 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 0.84963941 |
| 107 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.84091571 |
| 108 | PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse | 0.82708050 |
| 109 | EBNA1_20929547_Chip-Seq_RAJI-cells_Human | 0.82246014 |
| 110 | GATA6_21074721_ChIP-Seq_CACO-2_Mouse | 0.82200166 |
| 111 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 0.82092307 |
| 112 | AR_20517297_ChIP-Seq_VCAP_Human | 0.80688160 |
| 113 | GATA2_20887958_ChIP-Seq_HPC-7_Mouse | 0.80529498 |
| 114 | P63_20808887_ChIP-Seq_KERATINOCYTES_Human | 0.80465092 |
| 115 | RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.80267609 |
| 116 | SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human | 0.79548480 |
| 117 | GATA1_22383799_ChIP-Seq_G1ME_Mouse | 0.79184353 |
| 118 | FOXA1_21572438_ChIP-Seq_LNCaP_Human | 0.79022144 |
| 119 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.78534360 |
| 120 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 0.78094275 |
| 121 | OCT4_20526341_ChIP-Seq_ESCs_Human | 0.77358161 |
| 122 | CEBPB_22108803_ChIP-Seq_LS180_Human | 0.77286468 |
| 123 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 0.77145456 |
| 124 | NANOG_20526341_ChIP-Seq_ESCs_Human | 0.77086239 |
| 125 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 0.76932906 |
| 126 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 0.75643835 |
| 127 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 0.75427307 |
| 128 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 0.75427307 |
| 129 | TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.74604173 |
| 130 | CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse | 0.72593223 |
| 131 | ERA_21632823_ChIP-Seq_H3396_Human | 0.71644582 |
| 132 | TP53_22573176_ChIP-Seq_HFKS_Human | 0.71440753 |
| 133 | VDR_22108803_ChIP-Seq_LS180_Human | 0.71150181 |
| 134 | FOXH1_21741376_ChIP-Seq_EPCs_Human | 0.70863370 |
| 135 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 0.70802291 |
| 136 | TAF2_19829295_ChIP-Seq_ESCs_Human | 0.70561606 |
| 137 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 0.70289118 |
| 138 | VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human | 0.70237493 |
| 139 | EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human | 0.69700667 |
| 140 | E2F1_20622854_ChIP-Seq_HELA_Human | 0.68857745 |
| 141 | GATA6_21074721_ChIP-Seq_CACO-2_Human | 0.67919945 |
| 142 | NCOR_22424771_ChIP-Seq_293T_Human | 0.66955874 |
| 143 | GATA1_22025678_ChIP-Seq_K562_Human | 0.66596819 |
| 144 | PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse | 0.66474409 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003763_abnormal_thymus_physiology | 6.20336633 |
| 2 | MP0005671_abnormal_response_to | 5.57396288 |
| 3 | MP0002638_abnormal_pupillary_reflex | 4.30811822 |
| 4 | MP0000685_abnormal_immune_system | 3.45550867 |
| 5 | MP0009333_abnormal_splenocyte_physiolog | 3.35379925 |
| 6 | MP0001835_abnormal_antigen_presentation | 3.34848713 |
| 7 | MP0000703_abnormal_thymus_morphology | 3.24709337 |
| 8 | MP0001800_abnormal_humoral_immune | 3.19649467 |
| 9 | MP0002398_abnormal_bone_marrow | 3.13211697 |
| 10 | MP0002420_abnormal_adaptive_immunity | 3.08105372 |
| 11 | MP0001819_abnormal_immune_cell | 3.01988075 |
| 12 | MP0005000_abnormal_immune_tolerance | 2.86855261 |
| 13 | MP0002166_altered_tumor_susceptibility | 2.82403575 |
| 14 | MP0002723_abnormal_immune_serum | 2.77723386 |
| 15 | MP0000716_abnormal_immune_system | 2.66045740 |
| 16 | MP0002722_abnormal_immune_system | 2.63811379 |
| 17 | MP0002405_respiratory_system_inflammati | 2.59214270 |
| 18 | MP0001790_abnormal_immune_system | 2.52341116 |
| 19 | MP0005387_immune_system_phenotype | 2.52341116 |
| 20 | MP0002452_abnormal_antigen_presenting | 2.52202087 |
| 21 | MP0009785_altered_susceptibility_to | 2.49406331 |
| 22 | MP0005025_abnormal_response_to | 2.47875737 |
| 23 | MP0000689_abnormal_spleen_morphology | 2.45996995 |
| 24 | MP0006082_CNS_inflammation | 2.38779195 |
| 25 | MP0003300_gastrointestinal_ulcer | 2.37289103 |
| 26 | MP0002006_tumorigenesis | 2.34991459 |
| 27 | MP0002138_abnormal_hepatobiliary_system | 2.34909212 |
| 28 | MP0002396_abnormal_hematopoietic_system | 2.28773748 |
| 29 | MP0003436_decreased_susceptibility_to | 2.27269360 |
| 30 | MP0002429_abnormal_blood_cell | 2.17058052 |
| 31 | MP0004947_skin_inflammation | 2.11507868 |
| 32 | MP0003724_increased_susceptibility_to | 2.08665247 |
| 33 | MP0004147_increased_porphyrin_level | 2.02816181 |
| 34 | MP0003011_delayed_dark_adaptation | 2.02548542 |
| 35 | MP0002148_abnormal_hypersensitivity_rea | 2.00363854 |
| 36 | MP0003866_abnormal_defecation | 1.97716647 |
| 37 | MP0001873_stomach_inflammation | 1.96947390 |
| 38 | MP0010155_abnormal_intestine_physiology | 1.95196473 |
| 39 | MP0002933_joint_inflammation | 1.94148285 |
| 40 | MP0004381_abnormal_hair_follicle | 1.91067424 |
| 41 | MP0002419_abnormal_innate_immunity | 1.85497326 |
| 42 | MP0005464_abnormal_platelet_physiology | 1.76968860 |
| 43 | MP0000858_altered_metastatic_potential | 1.75398754 |
| 44 | MP0001845_abnormal_inflammatory_respons | 1.67400041 |
| 45 | MP0002877_abnormal_melanocyte_morpholog | 1.62598661 |
| 46 | MP0002163_abnormal_gland_morphology | 1.61157734 |
| 47 | MP0003448_altered_tumor_morphology | 1.53023032 |
| 48 | MP0002277_abnormal_respiratory_mucosa | 1.48125746 |
| 49 | MP0005075_abnormal_melanosome_morpholog | 1.46057877 |
| 50 | MP0001502_abnormal_circadian_rhythm | 1.44293405 |
| 51 | MP0004808_abnormal_hematopoietic_stem | 1.44157830 |
| 52 | MP0000465_gastrointestinal_hemorrhage | 1.43526195 |
| 53 | MP0001853_heart_inflammation | 1.42682393 |
| 54 | MP0003183_abnormal_peptide_metabolism | 1.40586369 |
| 55 | MP0001764_abnormal_homeostasis | 1.38435287 |
| 56 | MP0001905_abnormal_dopamine_level | 1.37643348 |
| 57 | MP0000372_irregular_coat_pigmentation | 1.36650861 |
| 58 | MP0004145_abnormal_muscle_electrophysio | 1.27386129 |
| 59 | MP0002019_abnormal_tumor_incidence | 1.22685035 |
| 60 | MP0008057_abnormal_DNA_replication | 1.17146805 |
| 61 | MP0010352_gastrointestinal_tract_polyps | 1.15053113 |
| 62 | MP0000569_abnormal_digit_pigmentation | 1.12398074 |
| 63 | MP0005379_endocrine/exocrine_gland_phen | 1.11268046 |
| 64 | MP0005253_abnormal_eye_physiology | 1.09206380 |
| 65 | MP0005645_abnormal_hypothalamus_physiol | 1.08869463 |
| 66 | MP0006054_spinal_hemorrhage | 1.08155577 |
| 67 | MP0001545_abnormal_hematopoietic_system | 1.06879099 |
| 68 | MP0005397_hematopoietic_system_phenotyp | 1.06879099 |
| 69 | MP0003303_peritoneal_inflammation | 1.05767377 |
| 70 | MP0000490_abnormal_crypts_of | 1.04093760 |
| 71 | MP0010094_abnormal_chromosome_stability | 1.02445700 |
| 72 | MP0004957_abnormal_blastocyst_morpholog | 1.01577462 |
| 73 | MP0008469_abnormal_protein_level | 0.99219265 |
| 74 | MP0002139_abnormal_hepatobiliary_system | 0.97603505 |
| 75 | MP0001533_abnormal_skeleton_physiology | 0.96430562 |
| 76 | MP0004043_abnormal_pH_regulation | 0.96199019 |
| 77 | MP0001881_abnormal_mammary_gland | 0.95655007 |
| 78 | MP0004510_myositis | 0.93718447 |
| 79 | MP0003077_abnormal_cell_cycle | 0.92693375 |
| 80 | MP0002909_abnormal_adrenal_gland | 0.91996678 |
| 81 | MP0005023_abnormal_wound_healing | 0.90746923 |
| 82 | MP0001968_abnormal_touch/_nociception | 0.89961835 |
| 83 | MP0001501_abnormal_sleep_pattern | 0.88132217 |
| 84 | MP0003806_abnormal_nucleotide_metabolis | 0.86708565 |
| 85 | MP0004142_abnormal_muscle_tone | 0.86183814 |
| 86 | MP0002009_preneoplasia | 0.85118100 |
| 87 | MP0001661_extended_life_span | 0.84194125 |
| 88 | MP0009763_increased_sensitivity_to | 0.82484866 |
| 89 | MP0000371_diluted_coat_color | 0.82327698 |
| 90 | MP0002102_abnormal_ear_morphology | 0.81935883 |
| 91 | MP0001542_abnormal_bone_strength | 0.81820914 |
| 92 | MP0003045_fibrosis | 0.80301950 |
| 93 | MP0009643_abnormal_urine_homeostasis | 0.77762358 |
| 94 | MP0003137_abnormal_impulse_conducting | 0.75901196 |
| 95 | MP0003786_premature_aging | 0.75818598 |
| 96 | MP0002132_abnormal_respiratory_system | 0.75581894 |
| 97 | MP0001851_eye_inflammation | 0.71740643 |
| 98 | MP0002998_abnormal_bone_remodeling | 0.70708100 |
| 99 | MP0009765_abnormal_xenobiotic_induced | 0.69702861 |
| 100 | MP0003693_abnormal_embryo_hatching | 0.69233482 |
| 101 | MP0005310_abnormal_salivary_gland | 0.67459370 |
| 102 | MP0000604_amyloidosis | 0.65569015 |
| 103 | MP0006292_abnormal_olfactory_placode | 0.64804710 |
| 104 | MP0002168_other_aberrant_phenotype | 0.63488254 |
| 105 | MP0000015_abnormal_ear_pigmentation | 0.61077287 |
| 106 | MP0000609_abnormal_liver_physiology | 0.59341144 |
| 107 | MP0005376_homeostasis/metabolism_phenot | 0.58351166 |
| 108 | MP0000477_abnormal_intestine_morphology | 0.57706877 |
| 109 | MP0005266_abnormal_metabolism | 0.57157577 |
| 110 | MP0001243_abnormal_dermal_layer | 0.56461795 |
| 111 | MP0005174_abnormal_tail_pigmentation | 0.56171899 |
| 112 | MP0008961_abnormal_basal_metabolism | 0.55965677 |
| 113 | MP0008874_decreased_physiological_sensi | 0.55558424 |
| 114 | MP0009278_abnormal_bone_marrow | 0.55287422 |
| 115 | MP0001348_abnormal_lacrimal_gland | 0.55266887 |
| 116 | MP0008007_abnormal_cellular_replicative | 0.53863028 |
| 117 | MP0001186_pigmentation_phenotype | 0.53252680 |
| 118 | MP0008873_increased_physiological_sensi | 0.53098361 |
| 119 | MP0000920_abnormal_myelination | 0.52924865 |
| 120 | MP0002136_abnormal_kidney_physiology | 0.52739418 |
| 121 | MP0002822_catalepsy | 0.52638379 |
| 122 | MP0003646_muscle_fatigue | 0.52345565 |
| 123 | MP0001188_hyperpigmentation | 0.51914269 |
| 124 | MP0010234_abnormal_vibrissa_follicle | 0.51851157 |
| 125 | MP0002837_dystrophic_cardiac_calcinosis | 0.51648776 |
| 126 | MP0009764_decreased_sensitivity_to | 0.51342259 |
| 127 | MP0000230_abnormal_systemic_arterial | 0.51336257 |
| 128 | MP0006276_abnormal_autonomic_nervous | 0.50867208 |
| 129 | MP0002693_abnormal_pancreas_physiology | 0.49494206 |
| 130 | MP0008058_abnormal_DNA_repair | 0.46417090 |
| 131 | MP0003111_abnormal_nucleus_morphology | 0.46363261 |
| 132 | MP0002083_premature_death | 0.46103046 |
| 133 | MP0000249_abnormal_blood_vessel | 0.45214592 |
| 134 | MP0001958_emphysema | 0.44985329 |
| 135 | MP0003795_abnormal_bone_structure | 0.44957942 |
| 136 | MP0000350_abnormal_cell_proliferation | 0.42703900 |
| 137 | MP0001730_embryonic_growth_arrest | 0.38645444 |
| 138 | MP0005076_abnormal_cell_differentiation | 0.38642781 |
| 139 | MP0000313_abnormal_cell_death | 0.38062694 |
| 140 | MP0001191_abnormal_skin_condition | 0.37917013 |
| 141 | MP0005166_decreased_susceptibility_to | 0.36646988 |
| 142 | MP0000367_abnormal_coat/_hair | 0.36614802 |
| 143 | MP0003453_abnormal_keratinocyte_physiol | 0.36397462 |
| 144 | MP0005408_hypopigmentation | 0.35779637 |
| 145 | MP0008569_lethality_at_weaning | 0.35623377 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | T lymphocytopenia (HP:0005403) | 9.92439389 |
| 2 | Abnormality of T cell number (HP:0011839) | 9.49769914 |
| 3 | Combined immunodeficiency (HP:0005387) | 6.22287596 |
| 4 | Elevated erythrocyte sedimentation rate (HP:0003565) | 6.21301047 |
| 5 | Severe combined immunodeficiency (HP:0004430) | 6.15296005 |
| 6 | Abnormality of T cells (HP:0002843) | 5.88506273 |
| 7 | Aplastic anemia (HP:0001915) | 5.68365035 |
| 8 | Recurrent viral infections (HP:0004429) | 5.07606198 |
| 9 | Eosinophilia (HP:0001880) | 4.79543330 |
| 10 | Panhypogammaglobulinemia (HP:0003139) | 4.74465537 |
| 11 | Abnormality of eosinophils (HP:0001879) | 4.60926171 |
| 12 | Chronic otitis media (HP:0000389) | 4.51961731 |
| 13 | IgG deficiency (HP:0004315) | 4.40176025 |
| 14 | Recurrent fungal infections (HP:0002841) | 4.29095043 |
| 15 | Recurrent bronchitis (HP:0002837) | 4.28166140 |
| 16 | Stomatitis (HP:0010280) | 4.19657348 |
| 17 | Myositis (HP:0100614) | 4.19607571 |
| 18 | Thyroiditis (HP:0100646) | 4.18307477 |
| 19 | Joint swelling (HP:0001386) | 4.14757836 |
| 20 | Nasal polyposis (HP:0100582) | 4.11071111 |
| 21 | Granulocytopenia (HP:0001913) | 4.09420020 |
| 22 | Autoimmune hemolytic anemia (HP:0001890) | 4.00121516 |
| 23 | Leukocytosis (HP:0001974) | 3.92951924 |
| 24 | Hypoplasia of the thymus (HP:0000778) | 3.63734867 |
| 25 | Lymphopenia (HP:0001888) | 3.62076159 |
| 26 | Pustule (HP:0200039) | 3.59281853 |
| 27 | Abnormality of cells of the lymphoid lineage (HP:0012140) | 3.49980413 |
| 28 | Acute hepatic failure (HP:0006554) | 3.48468836 |
| 29 | Abnormality of B cell number (HP:0010975) | 3.47767498 |
| 30 | B lymphocytopenia (HP:0010976) | 3.47767498 |
| 31 | Eczematoid dermatitis (HP:0000976) | 3.46496665 |
| 32 | IgM deficiency (HP:0002850) | 3.42484895 |
| 33 | Abnormality of the nasal mucosa (HP:0000433) | 3.40482721 |
| 34 | Bilateral sensorineural hearing impairment (HP:0008619) | 3.36931410 |
| 35 | Increased IgM level (HP:0003496) | 3.33609406 |
| 36 | Hemiplegia (HP:0002301) | 3.22492405 |
| 37 | Encephalitis (HP:0002383) | 3.19362804 |
| 38 | Abnormal delayed hypersensitivity skin test (HP:0002963) | 3.18883746 |
| 39 | Chronic diarrhea (HP:0002028) | 3.11846433 |
| 40 | Thrombocytosis (HP:0001894) | 3.07645235 |
| 41 | Autoimmune thrombocytopenia (HP:0001973) | 3.04327636 |
| 42 | Meningitis (HP:0001287) | 3.03841163 |
| 43 | Recurrent cutaneous fungal infections (HP:0011370) | 3.00618040 |
| 44 | Chronic mucocutaneous candidiasis (HP:0002728) | 3.00618040 |
| 45 | Abnormality of the fingertips (HP:0001211) | 2.93282009 |
| 46 | Lymphoma (HP:0002665) | 2.78136426 |
| 47 | Recurrent abscess formation (HP:0002722) | 2.74444618 |
| 48 | Recurrent otitis media (HP:0000403) | 2.71914345 |
| 49 | J-shaped sella turcica (HP:0002680) | 2.68782782 |
| 50 | Abnormality of macrophages (HP:0004311) | 2.68045506 |
| 51 | Basal cell carcinoma (HP:0002671) | 2.64830455 |
| 52 | Focal motor seizures (HP:0011153) | 2.64514071 |
| 53 | Spontaneous hematomas (HP:0007420) | 2.64001023 |
| 54 | Gastrointestinal infarctions (HP:0005244) | 2.63822381 |
| 55 | Abnormality of T cell physiology (HP:0011840) | 2.63693302 |
| 56 | Pancytopenia (HP:0001876) | 2.58818867 |
| 57 | Keratoconjunctivitis sicca (HP:0001097) | 2.55387860 |
| 58 | Sensory axonal neuropathy (HP:0003390) | 2.55336033 |
| 59 | Progressive neurologic deterioration (HP:0002344) | 2.54723650 |
| 60 | 3-Methylglutaconic aciduria (HP:0003535) | 2.53860410 |
| 61 | Verrucae (HP:0200043) | 2.52051587 |
| 62 | Papilloma (HP:0012740) | 2.52051587 |
| 63 | Retrobulbar optic neuritis (HP:0100654) | 2.51823191 |
| 64 | Optic neuritis (HP:0100653) | 2.51823191 |
| 65 | Hypergammaglobulinemia (HP:0010702) | 2.51423662 |
| 66 | Absent rod-and cone-mediated responses on ERG (HP:0007688) | 2.50906298 |
| 67 | Mediastinal lymphadenopathy (HP:0100721) | 2.49866001 |
| 68 | Abnormal albumin level (HP:0012116) | 2.48656568 |
| 69 | Hypoalbuminemia (HP:0003073) | 2.48656568 |
| 70 | Bronchitis (HP:0012387) | 2.48529373 |
| 71 | Severe visual impairment (HP:0001141) | 2.45912193 |
| 72 | Abnormality of oral frenula (HP:0000190) | 2.44894439 |
| 73 | Chronic sinusitis (HP:0011109) | 2.43675403 |
| 74 | Visual hallucinations (HP:0002367) | 2.39703169 |
| 75 | Abnormal platelet volume (HP:0011876) | 2.39676501 |
| 76 | Orchitis (HP:0100796) | 2.38899329 |
| 77 | Keratoconjunctivitis (HP:0001096) | 2.28205768 |
| 78 | Agammaglobulinemia (HP:0004432) | 2.24452446 |
| 79 | Hemoptysis (HP:0002105) | 2.21897985 |
| 80 | Recurrent skin infections (HP:0001581) | 2.21103685 |
| 81 | Cerebral hypomyelination (HP:0006808) | 2.20211580 |
| 82 | Abnormal rod and cone electroretinograms (HP:0008323) | 2.17521756 |
| 83 | Recurrent sinusitis (HP:0011108) | 2.17481185 |
| 84 | Amaurosis fugax (HP:0100576) | 2.16749657 |
| 85 | Vasculitis (HP:0002633) | 2.13993786 |
| 86 | Ureteral obstruction (HP:0006000) | 2.12993716 |
| 87 | Increased mean platelet volume (HP:0011877) | 2.09777576 |
| 88 | Abolished electroretinogram (ERG) (HP:0000550) | 2.08189421 |
| 89 | Trigonocephaly (HP:0000243) | 2.07932479 |
| 90 | Cellular immunodeficiency (HP:0005374) | 2.07881858 |
| 91 | Obstructive lung disease (HP:0006536) | 2.07691260 |
| 92 | Chronic obstructive pulmonary disease (HP:0006510) | 2.07691260 |
| 93 | Epistaxis (HP:0000421) | 2.07088234 |
| 94 | Gastrointestinal inflammation (HP:0004386) | 2.06663336 |
| 95 | Slow saccadic eye movements (HP:0000514) | 2.06276031 |
| 96 | Inflammation of the large intestine (HP:0002037) | 2.06226586 |
| 97 | Pulmonary infiltrates (HP:0002113) | 2.06021049 |
| 98 | Recurrent bacterial skin infections (HP:0005406) | 2.05644532 |
| 99 | Aplasia/Hypoplasia of the thymus (HP:0010515) | 2.05414041 |
| 100 | Increased IgE level (HP:0003212) | 2.02987574 |
| 101 | Gangrene (HP:0100758) | 2.00130667 |
| 102 | 11 pairs of ribs (HP:0000878) | 1.97939943 |
| 103 | Arterial thrombosis (HP:0004420) | 1.96853719 |
| 104 | Pulmonary embolism (HP:0002204) | 1.96097121 |
| 105 | Abnormality of the prostate (HP:0008775) | 1.93938671 |
| 106 | Skin rash (HP:0000988) | 1.93051524 |
| 107 | Hypoproteinemia (HP:0003075) | 1.90146295 |
| 108 | Prolonged bleeding time (HP:0003010) | 1.89711399 |
| 109 | Bronchiectasis (HP:0002110) | 1.85311027 |
| 110 | Multiple enchondromatosis (HP:0005701) | 1.84759773 |
| 111 | Chest pain (HP:0100749) | 1.83299472 |
| 112 | Aplasia/Hypoplasia of the macula (HP:0008059) | 1.82735826 |
| 113 | Petechiae (HP:0000967) | 1.82075204 |
| 114 | Colon cancer (HP:0003003) | 1.81643299 |
| 115 | Bicuspid aortic valve (HP:0001647) | 1.79103768 |
| 116 | Renal cortical cysts (HP:0000803) | 1.78086032 |
| 117 | Conical tooth (HP:0000698) | 1.77747123 |
| 118 | Increased neuronal autofluorescent lipopigment (HP:0002074) | 1.76755887 |
| 119 | Dislocated radial head (HP:0003083) | 1.75653078 |
| 120 | Periodontitis (HP:0000704) | 1.75559538 |
| 121 | Congenital stationary night blindness (HP:0007642) | 1.73510727 |
| 122 | Gingival bleeding (HP:0000225) | 1.73450417 |
| 123 | Poor speech (HP:0002465) | 1.73218582 |
| 124 | Type I transferrin isoform profile (HP:0003642) | 1.72524163 |
| 125 | Abnormality of dentin (HP:0010299) | 1.72235567 |
| 126 | Oral leukoplakia (HP:0002745) | 1.71807043 |
| 127 | Aplasia/Hypoplasia affecting the retina (HP:0008061) | 1.71127795 |
| 128 | Periorbital edema (HP:0100539) | 1.70953692 |
| 129 | Skin ulcer (HP:0200042) | 1.69700068 |
| 130 | Recurrent pneumonia (HP:0006532) | 1.69442269 |
| 131 | Broad palm (HP:0001169) | 1.69234852 |
| 132 | IgA deficiency (HP:0002720) | 1.68422599 |
| 133 | Abnormality of the pleura (HP:0002103) | 1.66412085 |
| 134 | Ureteral stenosis (HP:0000071) | 1.62859909 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | TXK | 7.85640478 |
| 2 | MAP4K1 | 6.12082623 |
| 3 | ITK | 3.39187712 |
| 4 | ZAP70 | 3.25632201 |
| 5 | STK10 | 3.07738088 |
| 6 | CDK19 | 2.83333477 |
| 7 | MST4 | 2.66320686 |
| 8 | JAK3 | 2.48115170 |
| 9 | GRK6 | 2.43680252 |
| 10 | TESK1 | 2.35356727 |
| 11 | FGFR4 | 2.15221381 |
| 12 | NLK | 2.13211066 |
| 13 | TYK2 | 2.08828577 |
| 14 | LCK | 2.07632291 |
| 15 | MAP3K11 | 1.91064143 |
| 16 | TEC | 1.87684640 |
| 17 | EEF2K | 1.82842185 |
| 18 | CSK | 1.82500794 |
| 19 | IKBKE | 1.80264291 |
| 20 | JAK1 | 1.75796744 |
| 21 | SYK | 1.72194298 |
| 22 | GRK7 | 1.69363828 |
| 23 | LIMK1 | 1.64012826 |
| 24 | LRRK2 | 1.49729061 |
| 25 | BTK | 1.48763415 |
| 26 | MAP3K14 | 1.45279601 |
| 27 | ZAK | 1.44455858 |
| 28 | TESK2 | 1.43777954 |
| 29 | CLK1 | 1.40064570 |
| 30 | FGFR3 | 1.37324376 |
| 31 | MAP3K10 | 1.35986273 |
| 32 | PKN2 | 1.32289628 |
| 33 | MAP3K13 | 1.31352532 |
| 34 | MAP4K2 | 1.25182282 |
| 35 | GRK1 | 1.23626590 |
| 36 | BCKDK | 1.22838809 |
| 37 | PRKCH | 1.22398144 |
| 38 | CAMKK2 | 1.22267728 |
| 39 | HCK | 1.19869224 |
| 40 | PRKCQ | 1.18503687 |
| 41 | MYLK | 1.16609843 |
| 42 | SCYL2 | 1.14700150 |
| 43 | NME2 | 1.13567398 |
| 44 | KDR | 1.08161824 |
| 45 | BLK | 1.01502569 |
| 46 | TBK1 | 1.00759386 |
| 47 | MARK3 | 0.93683256 |
| 48 | KIT | 0.93655421 |
| 49 | PIM1 | 0.92347930 |
| 50 | SIK2 | 0.91758365 |
| 51 | SIK1 | 0.91644840 |
| 52 | PASK | 0.89197839 |
| 53 | MAP3K7 | 0.88587217 |
| 54 | LYN | 0.86210275 |
| 55 | MAP3K3 | 0.86051645 |
| 56 | FES | 0.84824475 |
| 57 | EPHB1 | 0.83469931 |
| 58 | DAPK1 | 0.82440428 |
| 59 | TRPM7 | 0.82270551 |
| 60 | RIPK4 | 0.76278232 |
| 61 | FGR | 0.74548581 |
| 62 | PRPF4B | 0.74315255 |
| 63 | FGFR1 | 0.72816872 |
| 64 | TSSK6 | 0.71103564 |
| 65 | IRAK2 | 0.70026754 |
| 66 | VRK1 | 0.69307108 |
| 67 | CDK4 | 0.69039927 |
| 68 | FYN | 0.68010794 |
| 69 | NEK1 | 0.66026593 |
| 70 | STK4 | 0.65879811 |
| 71 | CSF1R | 0.64362385 |
| 72 | IKBKB | 0.62123773 |
| 73 | JAK2 | 0.62025727 |
| 74 | CDC7 | 0.61270507 |
| 75 | MELK | 0.57215792 |
| 76 | RPS6KA4 | 0.56562824 |
| 77 | MAP3K12 | 0.56334718 |
| 78 | TGFBR1 | 0.56219510 |
| 79 | PDGFRB | 0.55449988 |
| 80 | BMPR2 | 0.54666366 |
| 81 | INSR | 0.52575280 |
| 82 | SIK3 | 0.52574165 |
| 83 | IGF1R | 0.51775268 |
| 84 | MAPKAPK3 | 0.51591050 |
| 85 | RPS6KB2 | 0.50048511 |
| 86 | MARK2 | 0.49894819 |
| 87 | FLT3 | 0.48582724 |
| 88 | TAOK3 | 0.48544465 |
| 89 | PDK1 | 0.47125278 |
| 90 | TLK1 | 0.46258423 |
| 91 | ROCK1 | 0.45837138 |
| 92 | TGFBR2 | 0.45828083 |
| 93 | IRAK4 | 0.44896599 |
| 94 | HIPK2 | 0.41806566 |
| 95 | FGFR2 | 0.41207363 |
| 96 | CAMKK1 | 0.40749421 |
| 97 | MAPKAPK2 | 0.40745648 |
| 98 | MAPK7 | 0.39930669 |
| 99 | MAPK4 | 0.38781219 |
| 100 | MAP2K6 | 0.38332086 |
| 101 | TAOK2 | 0.37927592 |
| 102 | MAP3K8 | 0.37032595 |
| 103 | RPS6KA5 | 0.36853168 |
| 104 | EPHA3 | 0.36116519 |
| 105 | MAPK12 | 0.31800585 |
| 106 | PRKG2 | 0.31605809 |
| 107 | ALK | 0.31585973 |
| 108 | CDK6 | 0.30689683 |
| 109 | ILK | 0.30336471 |
| 110 | GRK5 | 0.29740684 |
| 111 | RPS6KA6 | 0.29563556 |
| 112 | MAPK11 | 0.29476186 |
| 113 | PIK3CG | 0.29358243 |
| 114 | IRAK1 | 0.29102474 |
| 115 | TNK2 | 0.28126667 |
| 116 | PRKACA | 0.27579536 |
| 117 | TYRO3 | 0.27532295 |
| 118 | WNK4 | 0.26290624 |
| 119 | TRIB3 | 0.25688380 |
| 120 | ROCK2 | 0.24514711 |
| 121 | MAPK3 | 0.24049446 |
| 122 | DYRK1B | 0.23637892 |
| 123 | NTRK2 | 0.23498813 |
| 124 | CHUK | 0.23248909 |
| 125 | ADRBK2 | 0.22206287 |
| 126 | RPS6KL1 | 0.20803933 |
| 127 | RPS6KC1 | 0.20803933 |
| 128 | AURKA | 0.20776583 |
| 129 | TTN | 0.20668365 |
| 130 | PRKAA1 | 0.20416870 |
| 131 | ERBB3 | 0.20071037 |
| 132 | PTK6 | 0.18964064 |
| 133 | SRC | 0.18766012 |
| 134 | ABL1 | 0.18427848 |
| 135 | BUB1 | 0.18382620 |
| 136 | NEK6 | 0.18266421 |
| 137 | MAPK9 | 0.18153820 |
| 138 | PRKCA | 0.17599233 |
| 139 | ATR | 0.17398102 |
| 140 | SRPK1 | 0.17381280 |
| 141 | MAP2K3 | 0.16456677 |
| 142 | TAOK1 | 0.16310327 |
| 143 | NEK2 | 0.16285395 |
| 144 | CDK12 | 0.16184453 |
| 145 | OBSCN | 0.14603421 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Primary immunodeficiency_Homo sapiens_hsa05340 | 6.18104438 |
| 2 | Graft-versus-host disease_Homo sapiens_hsa05332 | 4.66387826 |
| 3 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 4.51351849 |
| 4 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 3.89543406 |
| 5 | Antigen processing and presentation_Homo sapiens_hsa04612 | 3.13712955 |
| 6 | Measles_Homo sapiens_hsa05162 | 2.94106434 |
| 7 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 2.93870764 |
| 8 | Allograft rejection_Homo sapiens_hsa05330 | 2.56323321 |
| 9 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 2.34179914 |
| 10 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 2.30590030 |
| 11 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 2.15218762 |
| 12 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.92111090 |
| 13 | Ribosome_Homo sapiens_hsa03010 | 1.85272004 |
| 14 | Viral myocarditis_Homo sapiens_hsa05416 | 1.76350395 |
| 15 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 1.75134738 |
| 16 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 1.59475557 |
| 17 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 1.57453342 |
| 18 | Phototransduction_Homo sapiens_hsa04744 | 1.56835772 |
| 19 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 1.55539360 |
| 20 | Leishmaniasis_Homo sapiens_hsa05140 | 1.52693071 |
| 21 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 1.49304062 |
| 22 | Osteoclast differentiation_Homo sapiens_hsa04380 | 1.44309853 |
| 23 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.37361355 |
| 24 | Herpes simplex infection_Homo sapiens_hsa05168 | 1.32317994 |
| 25 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 1.30736382 |
| 26 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 1.29141635 |
| 27 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 1.26936333 |
| 28 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 1.25217550 |
| 29 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 1.23607247 |
| 30 | DNA replication_Homo sapiens_hsa03030 | 1.23405966 |
| 31 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 1.22076755 |
| 32 | HTLV-I infection_Homo sapiens_hsa05166 | 1.21260693 |
| 33 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 1.17559675 |
| 34 | Parkinsons disease_Homo sapiens_hsa05012 | 1.16577402 |
| 35 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 1.14655376 |
| 36 | Mismatch repair_Homo sapiens_hsa03430 | 1.13842702 |
| 37 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 1.08114103 |
| 38 | Colorectal cancer_Homo sapiens_hsa05210 | 1.06485748 |
| 39 | Hepatitis B_Homo sapiens_hsa05161 | 1.05853870 |
| 40 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 1.05418333 |
| 41 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 1.04505370 |
| 42 | Spliceosome_Homo sapiens_hsa03040 | 1.04335697 |
| 43 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 1.03512944 |
| 44 | Shigellosis_Homo sapiens_hsa05131 | 1.01485635 |
| 45 | Toxoplasmosis_Homo sapiens_hsa05145 | 1.01011861 |
| 46 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 1.00887340 |
| 47 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.00062640 |
| 48 | Olfactory transduction_Homo sapiens_hsa04740 | 0.96721510 |
| 49 | Apoptosis_Homo sapiens_hsa04210 | 0.90263480 |
| 50 | Influenza A_Homo sapiens_hsa05164 | 0.88401394 |
| 51 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.87733533 |
| 52 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.86233071 |
| 53 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.84226485 |
| 54 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.83631352 |
| 55 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.81347895 |
| 56 | Alzheimers disease_Homo sapiens_hsa05010 | 0.80927209 |
| 57 | Retinol metabolism_Homo sapiens_hsa00830 | 0.77649293 |
| 58 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.76178691 |
| 59 | Platelet activation_Homo sapiens_hsa04611 | 0.75269654 |
| 60 | TNF signaling pathway_Homo sapiens_hsa04668 | 0.74049845 |
| 61 | Prion diseases_Homo sapiens_hsa05020 | 0.72824430 |
| 62 | Asthma_Homo sapiens_hsa05310 | 0.72732948 |
| 63 | Legionellosis_Homo sapiens_hsa05134 | 0.71766070 |
| 64 | Peroxisome_Homo sapiens_hsa04146 | 0.66922045 |
| 65 | Base excision repair_Homo sapiens_hsa03410 | 0.66573657 |
| 66 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.66355914 |
| 67 | Salmonella infection_Homo sapiens_hsa05132 | 0.65232757 |
| 68 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.65171846 |
| 69 | Proteasome_Homo sapiens_hsa03050 | 0.64019316 |
| 70 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.62389121 |
| 71 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.60532591 |
| 72 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 0.60018761 |
| 73 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 0.59672337 |
| 74 | Hepatitis C_Homo sapiens_hsa05160 | 0.57190248 |
| 75 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 0.56415485 |
| 76 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.55075030 |
| 77 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.53887661 |
| 78 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.53214625 |
| 79 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.53183394 |
| 80 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.51907155 |
| 81 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.51815627 |
| 82 | Huntingtons disease_Homo sapiens_hsa05016 | 0.51686030 |
| 83 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.50423063 |
| 84 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.49859749 |
| 85 | Tuberculosis_Homo sapiens_hsa05152 | 0.49371756 |
| 86 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.47905859 |
| 87 | Nucleotide excision repair_Homo sapiens_hsa03420 | 0.47470310 |
| 88 | Malaria_Homo sapiens_hsa05144 | 0.46800106 |
| 89 | Protein export_Homo sapiens_hsa03060 | 0.45820108 |
| 90 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.45244516 |
| 91 | Endocytosis_Homo sapiens_hsa04144 | 0.44750769 |
| 92 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.42874621 |
| 93 | RNA degradation_Homo sapiens_hsa03018 | 0.41142557 |
| 94 | Morphine addiction_Homo sapiens_hsa05032 | 0.40010435 |
| 95 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.39613845 |
| 96 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.39544378 |
| 97 | Thyroid cancer_Homo sapiens_hsa05216 | 0.39492215 |
| 98 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.39045598 |
| 99 | Pertussis_Homo sapiens_hsa05133 | 0.38457379 |
| 100 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.38110068 |
| 101 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.36658190 |
| 102 | Basal transcription factors_Homo sapiens_hsa03022 | 0.34543521 |
| 103 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.33623274 |
| 104 | RNA transport_Homo sapiens_hsa03013 | 0.33560605 |
| 105 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.33489488 |
| 106 | Cell cycle_Homo sapiens_hsa04110 | 0.33268541 |
| 107 | Taste transduction_Homo sapiens_hsa04742 | 0.33251522 |
| 108 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.32312700 |
| 109 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.31732418 |
| 110 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.30314657 |
| 111 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.29187779 |
| 112 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.28052289 |
| 113 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.27098389 |
| 114 | Prostate cancer_Homo sapiens_hsa05215 | 0.26809514 |
| 115 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.26766061 |
| 116 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.26477368 |
| 117 | Homologous recombination_Homo sapiens_hsa03440 | 0.25125190 |
| 118 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.23901365 |
| 119 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.23765171 |
| 120 | Endometrial cancer_Homo sapiens_hsa05213 | 0.23729253 |
| 121 | Adherens junction_Homo sapiens_hsa04520 | 0.17718303 |
| 122 | Insulin resistance_Homo sapiens_hsa04931 | 0.17296917 |
| 123 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.15990622 |
| 124 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.15282092 |
| 125 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.15217986 |
| 126 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.14826727 |
| 127 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.14258105 |
| 128 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.13656930 |
| 129 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.13048607 |
| 130 | One carbon pool by folate_Homo sapiens_hsa00670 | 0.12969845 |
| 131 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.12866117 |
| 132 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.12249834 |
| 133 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.11502722 |
| 134 | Pathways in cancer_Homo sapiens_hsa05200 | 0.08853126 |
| 135 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.08709956 |
| 136 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.08689499 |
| 137 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.08378277 |
| 138 | Phagosome_Homo sapiens_hsa04145 | 0.07557983 |
| 139 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.05824053 |
| 140 | Calcium signaling pathway_Homo sapiens_hsa04020 | 0.05039143 |
| 141 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.04385978 |
| 142 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.02450086 |

