

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | positive regulation of tolerance induction (GO:0002645) | 9.35911962 |
| 2 | cytidine deamination (GO:0009972) | 8.49016606 |
| 3 | cytidine metabolic process (GO:0046087) | 8.49016606 |
| 4 | cytidine catabolic process (GO:0006216) | 8.49016606 |
| 5 | pyrimidine ribonucleoside catabolic process (GO:0046133) | 8.30200036 |
| 6 | regulation of tolerance induction (GO:0002643) | 8.24948123 |
| 7 | thymic T cell selection (GO:0045061) | 8.02036381 |
| 8 | positive regulation of gamma-delta T cell activation (GO:0046645) | 7.87253102 |
| 9 | positive regulation of interleukin-2 biosynthetic process (GO:0045086) | 7.69915849 |
| 10 | signal complex assembly (GO:0007172) | 7.48084030 |
| 11 | regulation of activation of Janus kinase activity (GO:0010533) | 7.39610577 |
| 12 | T cell selection (GO:0045058) | 7.13828660 |
| 13 | interferon-gamma production (GO:0032609) | 6.91568296 |
| 14 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 6.76804897 |
| 15 | positive thymic T cell selection (GO:0045059) | 6.51535354 |
| 16 | positive T cell selection (GO:0043368) | 6.51220645 |
| 17 | positive regulation of antigen receptor-mediated signaling pathway (GO:0050857) | 6.46864564 |
| 18 | T cell costimulation (GO:0031295) | 6.44339986 |
| 19 | positive regulation of alpha-beta T cell proliferation (GO:0046641) | 6.39963965 |
| 20 | antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885) | 6.33769826 |
| 21 | antigen processing and presentation of endogenous peptide antigen (GO:0002483) | 6.33769826 |
| 22 | regulation of gamma-delta T cell differentiation (GO:0045586) | 6.33179050 |
| 23 | lymphocyte costimulation (GO:0031294) | 6.32549793 |
| 24 | T cell receptor signaling pathway (GO:0050852) | 6.26648157 |
| 25 | negative regulation of leukocyte mediated cytotoxicity (GO:0001911) | 6.24206043 |
| 26 | negative regulation of cell killing (GO:0031342) | 6.24206043 |
| 27 | leukocyte aggregation (GO:0070486) | 6.06923043 |
| 28 | regulation of alpha-beta T cell proliferation (GO:0046640) | 6.05536447 |
| 29 | response to interleukin-15 (GO:0070672) | 5.90845926 |
| 30 | regulation of isotype switching to IgG isotypes (GO:0048302) | 5.85739333 |
| 31 | cellular response to interleukin-15 (GO:0071350) | 5.80534554 |
| 32 | regulation of interleukin-2 biosynthetic process (GO:0045076) | 5.76986925 |
| 33 | negative regulation by host of viral transcription (GO:0043922) | 5.67935460 |
| 34 | regulation of natural killer cell mediated cytotoxicity (GO:0042269) | 5.65923559 |
| 35 | regulation of natural killer cell mediated immunity (GO:0002715) | 5.65923559 |
| 36 | regulation of gamma-delta T cell activation (GO:0046643) | 5.62678208 |
| 37 | positive regulation of natural killer cell mediated immunity (GO:0002717) | 5.61766317 |
| 38 | positive regulation of natural killer cell mediated cytotoxicity (GO:0045954) | 5.61766317 |
| 39 | eosinophil chemotaxis (GO:0048245) | 5.48564057 |
| 40 | DNA deamination (GO:0045006) | 5.35837597 |
| 41 | antigen receptor-mediated signaling pathway (GO:0050851) | 5.34671337 |
| 42 | antigen processing and presentation of endogenous antigen (GO:0019883) | 5.29486593 |
| 43 | regulation of B cell receptor signaling pathway (GO:0050855) | 5.25739244 |
| 44 | regulation of T cell chemotaxis (GO:0010819) | 5.24720915 |
| 45 | positive regulation of T cell chemotaxis (GO:0010820) | 5.24720915 |
| 46 | regulation of chronic inflammatory response (GO:0002676) | 5.19602819 |
| 47 | T cell migration (GO:0072678) | 5.17237175 |
| 48 | regulation of macrophage chemotaxis (GO:0010758) | 5.00651923 |
| 49 | eosinophil migration (GO:0072677) | 4.94155539 |
| 50 | regulation of mononuclear cell migration (GO:0071675) | 4.92960060 |
| 51 | positive regulation of interleukin-4 production (GO:0032753) | 4.87052346 |
| 52 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G | 4.86512312 |
| 53 | gonadal mesoderm development (GO:0007506) | 4.83709543 |
| 54 | positive regulation of monocyte chemotaxis (GO:0090026) | 4.83307621 |
| 55 | regulation of antigen receptor-mediated signaling pathway (GO:0050854) | 4.76825127 |
| 56 | mast cell activation (GO:0045576) | 4.73294890 |
| 57 | activated T cell proliferation (GO:0050798) | 4.73233997 |
| 58 | regulation of T cell receptor signaling pathway (GO:0050856) | 4.72646135 |
| 59 | regulation of response to tumor cell (GO:0002834) | 4.69211023 |
| 60 | positive regulation of response to tumor cell (GO:0002836) | 4.69211023 |
| 61 | positive regulation of immune response to tumor cell (GO:0002839) | 4.69211023 |
| 62 | regulation of immune response to tumor cell (GO:0002837) | 4.69211023 |
| 63 | positive regulation of translational initiation (GO:0045948) | 4.61027178 |
| 64 | positive regulation of calcium-mediated signaling (GO:0050850) | 4.54104297 |
| 65 | positive regulation of interleukin-2 production (GO:0032743) | 4.53136666 |
| 66 | regulation of lymphocyte chemotaxis (GO:1901623) | 4.47231357 |
| 67 | macrophage chemotaxis (GO:0048246) | 4.36137296 |
| 68 | regulation of interleukin-4 production (GO:0032673) | 4.33794383 |
| 69 | negative regulation of T cell apoptotic process (GO:0070233) | 4.32736319 |
| 70 | negative regulation of viral genome replication (GO:0045071) | 4.22057813 |
| 71 | actin nucleation (GO:0045010) | 4.20650434 |
| 72 | sequestering of actin monomers (GO:0042989) | 4.19474376 |
| 73 | dendritic cell chemotaxis (GO:0002407) | 4.19130121 |
| 74 | negative regulation of T cell receptor signaling pathway (GO:0050860) | 4.18904453 |
| 75 | negative regulation of antigen receptor-mediated signaling pathway (GO:0050858) | 4.09491850 |
| 76 | positive regulation of leukocyte mediated cytotoxicity (GO:0001912) | 4.09364379 |
| 77 | regulation of leukocyte mediated cytotoxicity (GO:0001910) | 4.08812148 |
| 78 | pyrimidine nucleoside catabolic process (GO:0046135) | 4.03193764 |
| 79 | modulation by host of symbiont transcription (GO:0052472) | 3.99406738 |
| 80 | modulation by host of viral transcription (GO:0043921) | 3.99406738 |
| 81 | regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923) | 3.96632990 |
| 82 | regulation of chemokine-mediated signaling pathway (GO:0070099) | 3.95082521 |
| 83 | homeostasis of number of cells within a tissue (GO:0048873) | 3.86757879 |
| 84 | granulocyte activation (GO:0036230) | 3.80689747 |
| 85 | negative regulation of interleukin-12 production (GO:0032695) | 3.79677794 |
| 86 | cytolysis (GO:0019835) | 3.78730462 |
| 87 | immune response-activating cell surface receptor signaling pathway (GO:0002429) | 3.75503128 |
| 88 | T cell activation (GO:0042110) | 3.74533578 |
| 89 | modulation of transcription in other organism involved in symbiotic interaction (GO:0052312) | 3.73538233 |
| 90 | positive regulation of cell killing (GO:0031343) | 3.73415188 |
| 91 | regulation of cell killing (GO:0031341) | 3.73320756 |
| 92 | T cell differentiation (GO:0030217) | 3.69353381 |
| 93 | regulation of response to interferon-gamma (GO:0060330) | 3.66438948 |
| 94 | neutrophil activation (GO:0042119) | 3.62930913 |
| 95 | monocyte chemotaxis (GO:0002548) | 3.62882489 |
| 96 | positive regulation of B cell mediated immunity (GO:0002714) | 3.62084687 |
| 97 | positive regulation of immunoglobulin mediated immune response (GO:0002891) | 3.62084687 |
| 98 | regulation of interferon-gamma-mediated signaling pathway (GO:0060334) | 3.57779730 |
| 99 | positive regulation of T cell mediated cytotoxicity (GO:0001916) | 3.56227704 |
| 100 | regulation of T cell mediated cytotoxicity (GO:0001914) | 3.54937926 |
| 101 | positive regulation of lymphocyte migration (GO:2000403) | 3.51874896 |
| 102 | regulation of regulatory T cell differentiation (GO:0045589) | 3.51118043 |
| 103 | ribosomal small subunit assembly (GO:0000028) | 3.47445263 |
| 104 | lymphocyte chemotaxis (GO:0048247) | 3.46015386 |
| 105 | regulation of interleukin-2 production (GO:0032663) | 3.43150400 |
| 106 | dendritic cell migration (GO:0036336) | 3.42921733 |
| 107 | positive regulation of lamellipodium assembly (GO:0010592) | 3.42262971 |
| 108 | positive regulation of humoral immune response (GO:0002922) | 3.41578351 |
| 109 | cellular response to interleukin-4 (GO:0071353) | 3.41104571 |
| 110 | regulation of immunoglobulin mediated immune response (GO:0002889) | 3.40826114 |
| 111 | chemokine-mediated signaling pathway (GO:0070098) | 3.33518952 |
| 112 | regulation of viral genome replication (GO:0045069) | 3.32216798 |
| 113 | regulation of B cell mediated immunity (GO:0002712) | 3.30204353 |
| 114 | positive regulation of T cell activation (GO:0050870) | 3.29637645 |
| 115 | lymphocyte migration (GO:0072676) | 3.26968434 |
| 116 | alpha-beta T cell activation (GO:0046631) | 3.26768073 |
| 117 | mast cell activation involved in immune response (GO:0002279) | 3.26715439 |
| 118 | mast cell degranulation (GO:0043303) | 3.26715439 |
| 119 | leukocyte cell-cell adhesion (GO:0007159) | 3.25967940 |
| 120 | alpha-beta T cell differentiation (GO:0046632) | 3.25625215 |
| 121 | B cell receptor signaling pathway (GO:0050853) | 3.25523760 |
| 122 | positive regulation of T cell migration (GO:2000406) | 3.24852866 |
| 123 | positive regulation of isotype switching (GO:0045830) | 3.23926501 |
| 124 | regulation of monocyte chemotaxis (GO:0090025) | 3.23769687 |
| 125 | Arp2/3 complex-mediated actin nucleation (GO:0034314) | 3.23259934 |
| 126 | regulation of T cell migration (GO:2000404) | 3.20832538 |
| 127 | positive regulation of alpha-beta T cell activation (GO:0046635) | 3.20261024 |
| 128 | T cell homeostasis (GO:0043029) | 3.18515193 |
| 129 | negative regulation of viral transcription (GO:0032897) | 3.18120641 |
| 130 | positive regulation of T cell apoptotic process (GO:0070234) | 3.17743044 |
| 131 | negative regulation of stress fiber assembly (GO:0051497) | 3.15993121 |
| 132 | positive regulation of granulocyte differentiation (GO:0030854) | 3.15726041 |
| 133 | regulation of isotype switching (GO:0045191) | 3.15213328 |
| 134 | positive regulation of interferon-gamma production (GO:0032729) | 3.15047298 |
| 135 | regulation of calcium-mediated signaling (GO:0050848) | 3.14476807 |
| 136 | positive regulation of viral genome replication (GO:0045070) | 3.14131809 |
| 137 | regulation of lymphocyte migration (GO:2000401) | 3.14073710 |
| 138 | regulation of defense response to virus by virus (GO:0050690) | 3.13627690 |
| 139 | regulation of antigen processing and presentation of peptide antigen (GO:0002583) | 3.08374842 |
| 140 | cellular defense response (GO:0006968) | 3.08087804 |
| 141 | negative regulation of T cell mediated immunity (GO:0002710) | 3.04892567 |
| 142 | response to interleukin-4 (GO:0070670) | 3.02340570 |
| 143 | regulation of T cell activation (GO:0050863) | 3.02123078 |
| 144 | positive regulation of lymphocyte mediated immunity (GO:0002708) | 2.97190108 |
| 145 | regulation of alpha-beta T cell activation (GO:0046634) | 2.96879775 |
| 146 | positive regulation of immunoglobulin production (GO:0002639) | 2.93512358 |
| 147 | regulation of lymphocyte mediated immunity (GO:0002706) | 2.93409277 |
| 148 | regulation of B cell differentiation (GO:0045577) | 2.92346720 |
| 149 | regulation of T cell tolerance induction (GO:0002664) | 11.2724462 |
| 150 | negative T cell selection (GO:0043383) | 10.6003654 |
| 151 | negative thymic T cell selection (GO:0045060) | 10.2069724 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 7.76431246 |
| 2 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 6.67294177 |
| 3 | RUNX_20019798_ChIP-Seq_JUKART_Human | 4.16298757 |
| 4 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 4.05217518 |
| 5 | STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 4.00106863 |
| 6 | FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse | 3.74196956 |
| 7 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 3.69595891 |
| 8 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 3.61599808 |
| 9 | MYB_26560356_Chip-Seq_TH2_Human | 3.50327939 |
| 10 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 3.34735870 |
| 11 | MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 3.28412752 |
| 12 | MYC_22102868_ChIP-Seq_BL_Human | 3.13513164 |
| 13 | E2F7_22180533_ChIP-Seq_HELA_Human | 3.11625027 |
| 14 | MAF_26560356_Chip-Seq_TH1_Human | 3.05767205 |
| 15 | UTX_26944678_Chip-Seq_JUKART_Human | 2.92647861 |
| 16 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 2.91576969 |
| 17 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 2.86717840 |
| 18 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 2.81709853 |
| 19 | MYB_26560356_Chip-Seq_TH1_Human | 2.66373115 |
| 20 | GATA3_27048872_Chip-Seq_THYMUS_Human | 2.43815044 |
| 21 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 2.19663492 |
| 22 | MAF_26560356_Chip-Seq_TH2_Human | 2.19201460 |
| 23 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 2.13401097 |
| 24 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 2.05782265 |
| 25 | KDM2B_26808549_Chip-Seq_HPB-ALL_Human | 2.05472030 |
| 26 | RUNX1_22412390_ChIP-Seq_EML_Mouse | 1.99734694 |
| 27 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.98535145 |
| 28 | SPI1_23547873_ChIP-Seq_NB4_Human | 1.96377335 |
| 29 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 1.91209134 |
| 30 | E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 1.88574280 |
| 31 | VDR_21846776_ChIP-Seq_THP-1_Human | 1.87885947 |
| 32 | SCL_19346495_ChIP-Seq_HPC-7_Human | 1.86015272 |
| 33 | IRF8_27001747_Chip-Seq_BMDM_Mouse | 1.81554750 |
| 34 | SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse | 1.77064244 |
| 35 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.76406719 |
| 36 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.75390019 |
| 37 | RUNX1_17652178_ChIP-ChIP_JURKAT_Human | 1.74600417 |
| 38 | NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse | 1.73265557 |
| 39 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 1.73105341 |
| 40 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 1.72243701 |
| 41 | SPI1_23127762_ChIP-Seq_K562_Human | 1.71683912 |
| 42 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.69869534 |
| 43 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.67923472 |
| 44 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 1.64926438 |
| 45 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 1.64603238 |
| 46 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.59448654 |
| 47 | TCF7_22412390_ChIP-Seq_EML_Mouse | 1.55995941 |
| 48 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 1.55923115 |
| 49 | MEIS1_20887958_ChIP-Seq_HPC-7_Mouse | 1.52969926 |
| 50 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 1.48079917 |
| 51 | VDR_24763502_ChIP-Seq_THP-1_Human | 1.47705356 |
| 52 | KDM2B_26808549_Chip-Seq_DND41_Human | 1.45504247 |
| 53 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.41173503 |
| 54 | GATA3_26560356_Chip-Seq_TH2_Human | 1.32130197 |
| 55 | BCL6_27268052_Chip-Seq_Bcells_Human | 1.30768845 |
| 56 | VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human | 1.29327255 |
| 57 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 1.24170777 |
| 58 | PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.23716778 |
| 59 | GATA2_22383799_ChIP-Seq_G1ME_Mouse | 1.19476328 |
| 60 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.17698728 |
| 61 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 1.17680235 |
| 62 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.16541027 |
| 63 | BRD4_27068464_Chip-Seq_AML-cells_Mouse | 1.14519621 |
| 64 | CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.14299508 |
| 65 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.14050391 |
| 66 | PBX1_22567123_ChIP-ChIP_OVCAR3_Human | 1.13288163 |
| 67 | RBPJ_21746931_ChIP-Seq_IB4-LCL_Human | 1.12909126 |
| 68 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 1.12569171 |
| 69 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 1.11205379 |
| 70 | LMO2_20887958_ChIP-Seq_HPC-7_Mouse | 1.09935441 |
| 71 | CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.08842120 |
| 72 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.07862661 |
| 73 | BCOR_27268052_Chip-Seq_Bcells_Human | 1.07817030 |
| 74 | VDR_23849224_ChIP-Seq_CD4+_Human | 1.06899540 |
| 75 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 1.05341668 |
| 76 | TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse | 1.04997084 |
| 77 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.04348540 |
| 78 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.02049830 |
| 79 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.02008473 |
| 80 | PU_27001747_Chip-Seq_BMDM_Mouse | 1.01990454 |
| 81 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 0.99584058 |
| 82 | CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 0.98690729 |
| 83 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 0.98520681 |
| 84 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.97498953 |
| 85 | P300_27268052_Chip-Seq_Bcells_Human | 0.97137319 |
| 86 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 0.96322321 |
| 87 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 0.96215725 |
| 88 | SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human | 0.95579786 |
| 89 | KDM2B_26808549_Chip-Seq_JURKAT_Human | 0.95435380 |
| 90 | GATA1_22025678_ChIP-Seq_K562_Human | 0.95206125 |
| 91 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 0.95039814 |
| 92 | ELK1_19687146_ChIP-ChIP_HELA_Human | 0.92606137 |
| 93 | CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse | 0.92496164 |
| 94 | GATA3_26560356_Chip-Seq_TH1_Human | 0.91672765 |
| 95 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 0.91598010 |
| 96 | GATA2_20887958_ChIP-Seq_HPC-7_Mouse | 0.90303237 |
| 97 | PU.1_20513432_ChIP-Seq_Bcells_Mouse | 0.89629729 |
| 98 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 0.89545730 |
| 99 | FLI1_21867929_ChIP-Seq_CD8_Mouse | 0.89409185 |
| 100 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.88008558 |
| 101 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 0.86147188 |
| 102 | RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.85874819 |
| 103 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 0.84247444 |
| 104 | RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.84079863 |
| 105 | VDR_24787735_ChIP-Seq_THP-1_Human | 0.80122633 |
| 106 | YY1_22570637_ChIP-Seq_MALME-3M_Human | 0.80051365 |
| 107 | NANOG_20526341_ChIP-Seq_ESCs_Human | 0.80033432 |
| 108 | RXR_22108803_ChIP-Seq_LS180_Human | 0.79420040 |
| 109 | CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human | 0.78750133 |
| 110 | TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.77001440 |
| 111 | PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse | 0.75546006 |
| 112 | GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.75417829 |
| 113 | GATA1_22383799_ChIP-Seq_G1ME_Mouse | 0.75381392 |
| 114 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 0.74498356 |
| 115 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.73971547 |
| 116 | PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse | 0.73949056 |
| 117 | GATA1_19941826_ChIP-Seq_K562_Human | 0.72615801 |
| 118 | GATA2_19941826_ChIP-Seq_K562_Human | 0.72066082 |
| 119 | OCT4_20526341_ChIP-Seq_ESCs_Human | 0.71361053 |
| 120 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 0.70515611 |
| 121 | CTCF_20526341_ChIP-Seq_ESCs_Human | 0.69353740 |
| 122 | SPI1_20517297_ChIP-Seq_HL60_Human | 0.69118780 |
| 123 | EGR1_19032775_ChIP-ChIP_M12_Human | 0.68640865 |
| 124 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 0.68483728 |
| 125 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 0.68119794 |
| 126 | TP53_22573176_ChIP-Seq_HFKS_Human | 0.67302407 |
| 127 | P63_20808887_ChIP-Seq_KERATINOCYTES_Human | 0.65628363 |
| 128 | ERA_21632823_ChIP-Seq_H3396_Human | 0.64600351 |
| 129 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 0.64360016 |
| 130 | BMI1_19503595_ChIP-Seq_MEFsC_Mouse | 0.63827824 |
| 131 | FOXH1_21741376_ChIP-Seq_ESCs_Human | 0.63654537 |
| 132 | CTCF_21964334_Chip-Seq_Bcells_Human | 0.63635655 |
| 133 | RAC3_21632823_ChIP-Seq_H3396_Human | 0.62282788 |
| 134 | VDR_22108803_ChIP-Seq_LS180_Human | 0.62172021 |
| 135 | SA1_27219007_Chip-Seq_Bcells_Human | 0.61800733 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0005671_abnormal_response_to | 6.39034213 |
| 2 | MP0003763_abnormal_thymus_physiology | 5.68160267 |
| 3 | MP0001800_abnormal_humoral_immune | 3.39106925 |
| 4 | MP0001835_abnormal_antigen_presentation | 3.34024562 |
| 5 | MP0002420_abnormal_adaptive_immunity | 3.25168326 |
| 6 | MP0006082_CNS_inflammation | 3.22283701 |
| 7 | MP0000703_abnormal_thymus_morphology | 3.21156725 |
| 8 | MP0001819_abnormal_immune_cell | 3.17304312 |
| 9 | MP0002398_abnormal_bone_marrow | 3.12358253 |
| 10 | MP0009333_abnormal_splenocyte_physiolog | 3.08495066 |
| 11 | MP0000685_abnormal_immune_system | 3.05814929 |
| 12 | MP0005000_abnormal_immune_tolerance | 2.96258292 |
| 13 | MP0002723_abnormal_immune_serum | 2.85989918 |
| 14 | MP0003724_increased_susceptibility_to | 2.81493685 |
| 15 | MP0000716_abnormal_immune_system | 2.69894573 |
| 16 | MP0002452_abnormal_antigen_presenting | 2.63753096 |
| 17 | MP0002722_abnormal_immune_system | 2.62784683 |
| 18 | MP0005025_abnormal_response_to | 2.60640207 |
| 19 | MP0001790_abnormal_immune_system | 2.58995960 |
| 20 | MP0005387_immune_system_phenotype | 2.58995960 |
| 21 | MP0002166_altered_tumor_susceptibility | 2.56482095 |
| 22 | MP0002405_respiratory_system_inflammati | 2.52833157 |
| 23 | MP0000689_abnormal_spleen_morphology | 2.45261063 |
| 24 | MP0002933_joint_inflammation | 2.44496603 |
| 25 | MP0009785_altered_susceptibility_to | 2.43729438 |
| 26 | MP0002277_abnormal_respiratory_mucosa | 2.29409923 |
| 27 | MP0004947_skin_inflammation | 2.23216506 |
| 28 | MP0003436_decreased_susceptibility_to | 2.19673631 |
| 29 | MP0002429_abnormal_blood_cell | 2.18576614 |
| 30 | MP0002006_tumorigenesis | 2.06015859 |
| 31 | MP0000858_altered_metastatic_potential | 2.05424944 |
| 32 | MP0002148_abnormal_hypersensitivity_rea | 1.92910793 |
| 33 | MP0002419_abnormal_innate_immunity | 1.90697453 |
| 34 | MP0002396_abnormal_hematopoietic_system | 1.90388383 |
| 35 | MP0003300_gastrointestinal_ulcer | 1.88435279 |
| 36 | MP0010155_abnormal_intestine_physiology | 1.81213044 |
| 37 | MP0004381_abnormal_hair_follicle | 1.78131914 |
| 38 | MP0005464_abnormal_platelet_physiology | 1.77600195 |
| 39 | MP0001845_abnormal_inflammatory_respons | 1.69434058 |
| 40 | MP0003866_abnormal_defecation | 1.68997508 |
| 41 | MP0003448_altered_tumor_morphology | 1.55466924 |
| 42 | MP0001919_abnormal_reproductive_system | 1.48052645 |
| 43 | MP0005451_abnormal_body_composition | 1.45287465 |
| 44 | MP0001873_stomach_inflammation | 1.40556940 |
| 45 | MP0005075_abnormal_melanosome_morpholog | 1.40082316 |
| 46 | MP0003045_fibrosis | 1.35490999 |
| 47 | MP0008877_abnormal_DNA_methylation | 1.30095673 |
| 48 | MP0006054_spinal_hemorrhage | 1.26299582 |
| 49 | MP0004147_increased_porphyrin_level | 1.26265241 |
| 50 | MP0002254_reproductive_system_inflammat | 1.20706759 |
| 51 | MP0001851_eye_inflammation | 1.20555851 |
| 52 | MP0001533_abnormal_skeleton_physiology | 1.17169182 |
| 53 | MP0003786_premature_aging | 1.16545055 |
| 54 | MP0002019_abnormal_tumor_incidence | 1.12729076 |
| 55 | MP0004808_abnormal_hematopoietic_stem | 1.08243206 |
| 56 | MP0002877_abnormal_melanocyte_morpholog | 1.06924281 |
| 57 | MP0002909_abnormal_adrenal_gland | 1.03045076 |
| 58 | MP0002163_abnormal_gland_morphology | 1.02542680 |
| 59 | MP0008469_abnormal_protein_level | 1.01589707 |
| 60 | MP0010307_abnormal_tumor_latency | 1.01465140 |
| 61 | MP0000015_abnormal_ear_pigmentation | 1.00975457 |
| 62 | MP0001853_heart_inflammation | 1.00234503 |
| 63 | MP0009763_increased_sensitivity_to | 0.97295011 |
| 64 | MP0000465_gastrointestinal_hemorrhage | 0.96687462 |
| 65 | MP0003303_peritoneal_inflammation | 0.95253059 |
| 66 | MP0004510_myositis | 0.88297890 |
| 67 | MP0003806_abnormal_nucleotide_metabolis | 0.87344364 |
| 68 | MP0000920_abnormal_myelination | 0.87295744 |
| 69 | MP0002009_preneoplasia | 0.86509511 |
| 70 | MP0000490_abnormal_crypts_of | 0.85245822 |
| 71 | MP0002998_abnormal_bone_remodeling | 0.85018978 |
| 72 | MP0001501_abnormal_sleep_pattern | 0.83812565 |
| 73 | MP0000604_amyloidosis | 0.83679343 |
| 74 | MP0005023_abnormal_wound_healing | 0.83214980 |
| 75 | MP0002132_abnormal_respiratory_system | 0.81939234 |
| 76 | MP0005389_reproductive_system_phenotype | 0.79039784 |
| 77 | MP0005058_abnormal_lysosome_morphology | 0.78952903 |
| 78 | MP0008872_abnormal_physiological_respon | 0.78691200 |
| 79 | MP0009765_abnormal_xenobiotic_induced | 0.75949893 |
| 80 | MP0002168_other_aberrant_phenotype | 0.75612324 |
| 81 | MP0010352_gastrointestinal_tract_polyps | 0.75503948 |
| 82 | MP0001727_abnormal_embryo_implantation | 0.74289365 |
| 83 | MP0005266_abnormal_metabolism | 0.71953882 |
| 84 | MP0006276_abnormal_autonomic_nervous | 0.70328204 |
| 85 | MP0000609_abnormal_liver_physiology | 0.67778883 |
| 86 | MP0001542_abnormal_bone_strength | 0.67703440 |
| 87 | MP0004130_abnormal_muscle_cell | 0.67317518 |
| 88 | MP0003011_delayed_dark_adaptation | 0.66762998 |
| 89 | MP0008961_abnormal_basal_metabolism | 0.66577656 |
| 90 | MP0002876_abnormal_thyroid_physiology | 0.65840378 |
| 91 | MP0002136_abnormal_kidney_physiology | 0.64665573 |
| 92 | MP0008995_early_reproductive_senescence | 0.63800571 |
| 93 | MP0002095_abnormal_skin_pigmentation | 0.63547694 |
| 94 | MP0008873_increased_physiological_sensi | 0.63055042 |
| 95 | MP0001346_abnormal_lacrimal_gland | 0.61801106 |
| 96 | MP0001881_abnormal_mammary_gland | 0.60169709 |
| 97 | MP0000249_abnormal_blood_vessel | 0.59709521 |
| 98 | MP0010234_abnormal_vibrissa_follicle | 0.59552237 |
| 99 | MP0005310_abnormal_salivary_gland | 0.59230884 |
| 100 | MP0005584_abnormal_enzyme/coenzyme_acti | 0.58771216 |
| 101 | MP0005379_endocrine/exocrine_gland_phen | 0.58047878 |
| 102 | MP0001299_abnormal_eye_distance/ | 0.57718862 |
| 103 | MP0003183_abnormal_peptide_metabolism | 0.57480831 |
| 104 | MP0005408_hypopigmentation | 0.56912604 |
| 105 | MP0009764_decreased_sensitivity_to | 0.56250887 |
| 106 | MP0001348_abnormal_lacrimal_gland | 0.54329240 |
| 107 | MP0004957_abnormal_blastocyst_morpholog | 0.53534120 |
| 108 | MP0001545_abnormal_hematopoietic_system | 0.53391210 |
| 109 | MP0005397_hematopoietic_system_phenotyp | 0.53391210 |
| 110 | MP0001243_abnormal_dermal_layer | 0.53236731 |
| 111 | MP0002083_premature_death | 0.51884868 |
| 112 | MP0001968_abnormal_touch/_nociception | 0.51841544 |
| 113 | MP0000477_abnormal_intestine_morphology | 0.50681362 |
| 114 | MP0005377_hearing/vestibular/ear_phenot | 0.49943944 |
| 115 | MP0003878_abnormal_ear_physiology | 0.49943944 |
| 116 | MP0002693_abnormal_pancreas_physiology | 0.49315126 |
| 117 | MP0005166_decreased_susceptibility_to | 0.48430986 |
| 118 | MP0000343_altered_response_to | 0.47776748 |
| 119 | MP0001191_abnormal_skin_condition | 0.45180932 |
| 120 | MP0003172_abnormal_lysosome_physiology | 0.44236399 |
| 121 | MP0003795_abnormal_bone_structure | 0.44183648 |
| 122 | MP0001188_hyperpigmentation | 0.43138247 |
| 123 | MP0009643_abnormal_urine_homeostasis | 0.42591813 |
| 124 | MP0001958_emphysema | 0.42587427 |
| 125 | MP0004134_abnormal_chest_morphology | 0.42145493 |
| 126 | MP0000372_irregular_coat_pigmentation | 0.41238832 |
| 127 | MP0005360_urolithiasis | 0.40942245 |
| 128 | MP0000598_abnormal_liver_morphology | 0.39550009 |
| 129 | MP0008057_abnormal_DNA_replication | 0.36956987 |
| 130 | MP0003077_abnormal_cell_cycle | 0.36182665 |
| 131 | MP0003279_aneurysm | 0.35647648 |
| 132 | MP0003656_abnormal_erythrocyte_physiolo | 0.34564825 |
| 133 | MP0005076_abnormal_cell_differentiation | 0.33549359 |
| 134 | MP0000013_abnormal_adipose_tissue | 0.32661565 |
| 135 | MP0002822_catalepsy | 0.29717237 |
| 136 | MP0000367_abnormal_coat/_hair | 0.29631597 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | T lymphocytopenia (HP:0005403) | 9.50683544 |
| 2 | Abnormality of T cell number (HP:0011839) | 9.10579448 |
| 3 | Elevated erythrocyte sedimentation rate (HP:0003565) | 6.68595360 |
| 4 | Combined immunodeficiency (HP:0005387) | 6.29658235 |
| 5 | Severe combined immunodeficiency (HP:0004430) | 5.93577639 |
| 6 | Abnormality of T cells (HP:0002843) | 5.55764122 |
| 7 | Recurrent viral infections (HP:0004429) | 4.99830466 |
| 8 | Autoimmune hemolytic anemia (HP:0001890) | 4.92707797 |
| 9 | Panhypogammaglobulinemia (HP:0003139) | 4.74338995 |
| 10 | Eczematoid dermatitis (HP:0000976) | 4.71640418 |
| 11 | Nasal polyposis (HP:0100582) | 4.56926017 |
| 12 | Hypoproteinemia (HP:0003075) | 4.47919459 |
| 13 | Joint swelling (HP:0001386) | 4.43290008 |
| 14 | Lymphopenia (HP:0001888) | 4.40436818 |
| 15 | Chronic otitis media (HP:0000389) | 4.39440133 |
| 16 | Recurrent bronchitis (HP:0002837) | 4.23065596 |
| 17 | Abnormality of cells of the lymphoid lineage (HP:0012140) | 4.21327561 |
| 18 | Eosinophilia (HP:0001880) | 4.15282222 |
| 19 | Recurrent fungal infections (HP:0002841) | 4.13197343 |
| 20 | Abnormality of eosinophils (HP:0001879) | 4.10076429 |
| 21 | Aplastic anemia (HP:0001915) | 3.99354031 |
| 22 | Stomatitis (HP:0010280) | 3.93146695 |
| 23 | Myositis (HP:0100614) | 3.92919424 |
| 24 | IgG deficiency (HP:0004315) | 3.91356611 |
| 25 | Abnormality of the nasal mucosa (HP:0000433) | 3.84454965 |
| 26 | Leukocytosis (HP:0001974) | 3.68370616 |
| 27 | Recurrent otitis media (HP:0000403) | 3.53189989 |
| 28 | Granulocytopenia (HP:0001913) | 3.45990826 |
| 29 | Acute hepatic failure (HP:0006554) | 3.45780996 |
| 30 | Autoimmune thrombocytopenia (HP:0001973) | 3.38477421 |
| 31 | Sensory axonal neuropathy (HP:0003390) | 3.36714051 |
| 32 | Pustule (HP:0200039) | 3.36379272 |
| 33 | Recurrent abscess formation (HP:0002722) | 3.28621781 |
| 34 | Increased IgM level (HP:0003496) | 3.24128225 |
| 35 | IgM deficiency (HP:0002850) | 3.19647398 |
| 36 | Thyroiditis (HP:0100646) | 3.13421334 |
| 37 | Cutaneous melanoma (HP:0012056) | 3.12129669 |
| 38 | Severe visual impairment (HP:0001141) | 3.10769364 |
| 39 | Mediastinal lymphadenopathy (HP:0100721) | 3.07583018 |
| 40 | Chronic diarrhea (HP:0002028) | 3.03250245 |
| 41 | Abnormal albumin level (HP:0012116) | 3.02710733 |
| 42 | Hypoalbuminemia (HP:0003073) | 3.02710733 |
| 43 | Keratitis (HP:0000491) | 3.02497575 |
| 44 | Gastrointestinal infarctions (HP:0005244) | 2.99568192 |
| 45 | Meningitis (HP:0001287) | 2.98005703 |
| 46 | Chronic mucocutaneous candidiasis (HP:0002728) | 2.95918091 |
| 47 | Recurrent cutaneous fungal infections (HP:0011370) | 2.95918091 |
| 48 | Encephalitis (HP:0002383) | 2.93950016 |
| 49 | IgA deficiency (HP:0002720) | 2.93946362 |
| 50 | Hypoplasia of the thymus (HP:0000778) | 2.93805142 |
| 51 | Thrombocytosis (HP:0001894) | 2.80463480 |
| 52 | Abnormality of oral frenula (HP:0000190) | 2.78637893 |
| 53 | Abnormal delayed hypersensitivity skin test (HP:0002963) | 2.71685746 |
| 54 | Episodic fever (HP:0001954) | 2.69401372 |
| 55 | Agammaglobulinemia (HP:0004432) | 2.66773007 |
| 56 | Cerebral palsy (HP:0100021) | 2.60156994 |
| 57 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 2.57085328 |
| 58 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 2.57085328 |
| 59 | Recurrent corneal erosions (HP:0000495) | 2.56765166 |
| 60 | Multiple enchondromatosis (HP:0005701) | 2.56360826 |
| 61 | Recurrent bacterial skin infections (HP:0005406) | 2.49427719 |
| 62 | Oral leukoplakia (HP:0002745) | 2.49302840 |
| 63 | Recurrent skin infections (HP:0001581) | 2.49231278 |
| 64 | Bronchitis (HP:0012387) | 2.44635685 |
| 65 | Hemiplegia (HP:0002301) | 2.44362889 |
| 66 | Recurrent sinusitis (HP:0011108) | 2.41838735 |
| 67 | Hypergammaglobulinemia (HP:0010702) | 2.41068230 |
| 68 | Lymphoma (HP:0002665) | 2.39569775 |
| 69 | Increased intramyocellular lipid droplets (HP:0012240) | 2.39404153 |
| 70 | Increased CSF protein (HP:0002922) | 2.38463529 |
| 71 | Basal cell carcinoma (HP:0002671) | 2.33861709 |
| 72 | B lymphocytopenia (HP:0010976) | 2.32844788 |
| 73 | Abnormality of B cell number (HP:0010975) | 2.32844788 |
| 74 | Verrucae (HP:0200043) | 2.32266768 |
| 75 | Papilloma (HP:0012740) | 2.32266768 |
| 76 | 3-Methylglutaconic aciduria (HP:0003535) | 2.29334100 |
| 77 | Abnormality of T cell physiology (HP:0011840) | 2.29007023 |
| 78 | Abnormality of the fingertips (HP:0001211) | 2.26429929 |
| 79 | Obstructive lung disease (HP:0006536) | 2.26011246 |
| 80 | Chronic obstructive pulmonary disease (HP:0006510) | 2.26011246 |
| 81 | Trigonocephaly (HP:0000243) | 2.23210893 |
| 82 | Arthropathy (HP:0003040) | 2.19186806 |
| 83 | Amaurosis fugax (HP:0100576) | 2.18882828 |
| 84 | Tetraplegia (HP:0002445) | 2.18121895 |
| 85 | Diplopia (HP:0000651) | 2.16354422 |
| 86 | Abnormality of binocular vision (HP:0011514) | 2.16354422 |
| 87 | Increased muscle lipid content (HP:0009058) | 2.15877048 |
| 88 | Pulmonary infiltrates (HP:0002113) | 2.13580398 |
| 89 | Renal cortical cysts (HP:0000803) | 2.13433663 |
| 90 | Abnormality of the prostate (HP:0008775) | 2.12260833 |
| 91 | Chronic sinusitis (HP:0011109) | 2.12044486 |
| 92 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.11932337 |
| 93 | Spontaneous hematomas (HP:0007420) | 2.11567321 |
| 94 | Slow saccadic eye movements (HP:0000514) | 2.09443719 |
| 95 | Orchitis (HP:0100796) | 2.09373248 |
| 96 | Squamous cell carcinoma (HP:0002860) | 2.08310789 |
| 97 | Inflammation of the large intestine (HP:0002037) | 2.08153052 |
| 98 | Amyotrophic lateral sclerosis (HP:0007354) | 2.07727231 |
| 99 | Gastrointestinal inflammation (HP:0004386) | 2.05866243 |
| 100 | Vasculitis (HP:0002633) | 2.05259078 |
| 101 | Vacuolated lymphocytes (HP:0001922) | 2.02961957 |
| 102 | Hepatosplenomegaly (HP:0001433) | 2.01076101 |
| 103 | Gangrene (HP:0100758) | 1.99629160 |
| 104 | Hemoptysis (HP:0002105) | 1.97154575 |
| 105 | Keratoconjunctivitis sicca (HP:0001097) | 1.96412641 |
| 106 | Periodontitis (HP:0000704) | 1.94183381 |
| 107 | J-shaped sella turcica (HP:0002680) | 1.94141215 |
| 108 | Abnormality of dental color (HP:0011073) | 1.93573208 |
| 109 | Type I transferrin isoform profile (HP:0003642) | 1.90936883 |
| 110 | Parakeratosis (HP:0001036) | 1.90236888 |
| 111 | Dislocated radial head (HP:0003083) | 1.90217279 |
| 112 | Entropion (HP:0000621) | 1.90118030 |
| 113 | Epistaxis (HP:0000421) | 1.89975007 |
| 114 | Chest pain (HP:0100749) | 1.88793945 |
| 115 | Bronchiectasis (HP:0002110) | 1.86454038 |
| 116 | Striae distensae (HP:0001065) | 1.84835144 |
| 117 | Pancytopenia (HP:0001876) | 1.84667750 |
| 118 | Abnormal platelet volume (HP:0011876) | 1.84237164 |
| 119 | Pulmonary embolism (HP:0002204) | 1.83256900 |
| 120 | Toxemia of pregnancy (HP:0100603) | 1.82412048 |
| 121 | Ureteral obstruction (HP:0006000) | 1.80708438 |
| 122 | Abnormality of macrophages (HP:0004311) | 1.80199062 |
| 123 | Purpura (HP:0000979) | 1.79100573 |
| 124 | Ureteral stenosis (HP:0000071) | 1.78811105 |
| 125 | Agnosia (HP:0010524) | 1.78436023 |
| 126 | Abnormality of the radial head (HP:0003995) | 1.76237442 |
| 127 | Abnormality of the alveolar ridges (HP:0006477) | 1.76215261 |
| 128 | Colon cancer (HP:0003003) | 1.75730864 |
| 129 | Colitis (HP:0002583) | 1.74384806 |
| 130 | Skin rash (HP:0000988) | 1.73817795 |
| 131 | Optic neuritis (HP:0100653) | 1.73701147 |
| 132 | Retrobulbar optic neuritis (HP:0100654) | 1.73701147 |
| 133 | Cellular immunodeficiency (HP:0005374) | 1.73488335 |
| 134 | Arterial thrombosis (HP:0004420) | 1.72860698 |
| 135 | Keratoconjunctivitis (HP:0001096) | 1.72693039 |
| 136 | Abnormality of the pleura (HP:0002103) | 1.72173715 |
| 137 | Methylmalonic acidemia (HP:0002912) | 1.71198175 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | TXK | 8.96437202 |
| 2 | MAP4K1 | 6.15889447 |
| 3 | ZAP70 | 3.53847844 |
| 4 | ITK | 3.19889213 |
| 5 | STK10 | 2.89648055 |
| 6 | CAMKK2 | 2.78550028 |
| 7 | BCKDK | 2.71775220 |
| 8 | MST4 | 2.51820570 |
| 9 | GRK7 | 2.42743324 |
| 10 | TESK1 | 2.38667740 |
| 11 | MAP3K11 | 2.27800645 |
| 12 | LCK | 2.21352537 |
| 13 | GRK6 | 2.06270908 |
| 14 | MAP3K6 | 2.04271888 |
| 15 | JAK3 | 1.93931683 |
| 16 | TYK2 | 1.88300360 |
| 17 | FGFR4 | 1.87738352 |
| 18 | IKBKE | 1.84739666 |
| 19 | JAK1 | 1.82197876 |
| 20 | SYK | 1.82152293 |
| 21 | TEC | 1.78006318 |
| 22 | CSK | 1.67776888 |
| 23 | LRRK2 | 1.66237107 |
| 24 | NLK | 1.62359670 |
| 25 | MATK | 1.60986455 |
| 26 | NTRK1 | 1.52249724 |
| 27 | BLK | 1.49216206 |
| 28 | LIMK1 | 1.46822528 |
| 29 | WNK4 | 1.39822307 |
| 30 | KDR | 1.37838035 |
| 31 | NME1 | 1.34062278 |
| 32 | TESK2 | 1.33622557 |
| 33 | BMPR2 | 1.30310304 |
| 34 | RIPK4 | 1.29571986 |
| 35 | PRKCH | 1.29395861 |
| 36 | BTK | 1.28012377 |
| 37 | MAP3K13 | 1.23574675 |
| 38 | EEF2K | 1.22854184 |
| 39 | TBK1 | 1.22668119 |
| 40 | MAP3K14 | 1.20209305 |
| 41 | CAMKK1 | 1.15978994 |
| 42 | PRKCQ | 1.13180227 |
| 43 | CLK1 | 1.12227836 |
| 44 | FGFR1 | 1.07136223 |
| 45 | MAP3K12 | 1.06871170 |
| 46 | BRSK1 | 1.06421327 |
| 47 | FES | 1.05571251 |
| 48 | HCK | 1.05324963 |
| 49 | MAP4K2 | 1.01636221 |
| 50 | LYN | 1.01332470 |
| 51 | IKBKB | 0.99990012 |
| 52 | FGFR3 | 0.98535563 |
| 53 | FYN | 0.98200959 |
| 54 | KIT | 0.97677122 |
| 55 | CSF1R | 0.97000232 |
| 56 | SIK2 | 0.92745241 |
| 57 | PKN2 | 0.91631018 |
| 58 | PRPF4B | 0.87765736 |
| 59 | PASK | 0.87143371 |
| 60 | DAPK2 | 0.84933445 |
| 61 | MARK3 | 0.76791518 |
| 62 | IGF1R | 0.71088584 |
| 63 | PIM1 | 0.69640104 |
| 64 | EPHB1 | 0.69290729 |
| 65 | TGFBR1 | 0.69019795 |
| 66 | ERN1 | 0.67222407 |
| 67 | MAPKAPK2 | 0.65346332 |
| 68 | MARK2 | 0.64932955 |
| 69 | INSR | 0.64825218 |
| 70 | GRK5 | 0.64547483 |
| 71 | IRAK4 | 0.59924598 |
| 72 | PIK3CA | 0.57077509 |
| 73 | TAOK1 | 0.55212697 |
| 74 | MAP3K7 | 0.54854590 |
| 75 | RPS6KA4 | 0.51434820 |
| 76 | ERBB2 | 0.49992025 |
| 77 | FLT3 | 0.49780964 |
| 78 | MAP3K10 | 0.48261130 |
| 79 | PDGFRB | 0.47966756 |
| 80 | ALK | 0.47020885 |
| 81 | MOS | 0.46964225 |
| 82 | NME2 | 0.46823125 |
| 83 | GRK1 | 0.46548335 |
| 84 | PDK1 | 0.46486230 |
| 85 | TGFBR2 | 0.46101383 |
| 86 | SIK3 | 0.45193230 |
| 87 | BCR | 0.45177766 |
| 88 | JAK2 | 0.44276299 |
| 89 | BRSK2 | 0.44209452 |
| 90 | TRIB3 | 0.43576127 |
| 91 | CDK4 | 0.42453851 |
| 92 | MAPK13 | 0.41990381 |
| 93 | EPHA3 | 0.38020487 |
| 94 | ILK | 0.37849723 |
| 95 | FGR | 0.37769363 |
| 96 | ROCK2 | 0.36678001 |
| 97 | MAPK4 | 0.36166420 |
| 98 | STK4 | 0.35771882 |
| 99 | MAPK7 | 0.35276454 |
| 100 | MAPK12 | 0.32207268 |
| 101 | TNK2 | 0.31721360 |
| 102 | NTRK2 | 0.29734253 |
| 103 | MAPK3 | 0.28215252 |
| 104 | ADRBK2 | 0.27617980 |
| 105 | CHUK | 0.27314930 |
| 106 | MAPK9 | 0.26906614 |
| 107 | STK39 | 0.24858966 |
| 108 | HIPK2 | 0.24434582 |
| 109 | SRC | 0.22813023 |
| 110 | PIM2 | 0.21880862 |
| 111 | PRKD2 | 0.21758686 |
| 112 | AURKA | 0.21633832 |
| 113 | MAP3K8 | 0.20923405 |
| 114 | MAPK11 | 0.20855855 |
| 115 | MYLK | 0.20809434 |
| 116 | BMX | 0.20480897 |
| 117 | RET | 0.18820743 |
| 118 | PRKCB | 0.18816856 |
| 119 | PRKCD | 0.18505004 |
| 120 | RPS6KA5 | 0.18306688 |
| 121 | TRPM7 | 0.17581282 |
| 122 | SIK1 | 0.17449428 |
| 123 | ARAF | 0.16748428 |
| 124 | CDK6 | 0.16686840 |
| 125 | TLK1 | 0.16165435 |
| 126 | MAP2K6 | 0.15943292 |
| 127 | TAOK3 | 0.15724855 |
| 128 | RPS6KA6 | 0.15413128 |
| 129 | PAK4 | 0.15167659 |
| 130 | PRKCA | 0.14544328 |
| 131 | ROCK1 | 0.14054995 |
| 132 | ATR | 0.14054697 |
| 133 | STK11 | 0.14015987 |
| 134 | NUAK1 | 0.13389277 |
| 135 | DAPK1 | 0.12991170 |
| 136 | TYRO3 | 0.12348537 |
| 137 | CSNK1G3 | 0.12242003 |
| 138 | BUB1 | 0.11973675 |
| 139 | CDC7 | 0.11885364 |
| 140 | PRKACA | 0.11542528 |
| 141 | CAMK1 | 0.11263945 |
| 142 | PTK6 | 0.11029945 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Primary immunodeficiency_Homo sapiens_hsa05340 | 6.89672240 |
| 2 | Graft-versus-host disease_Homo sapiens_hsa05332 | 5.67887068 |
| 3 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 4.96719053 |
| 4 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 4.50405728 |
| 5 | Antigen processing and presentation_Homo sapiens_hsa04612 | 3.74389291 |
| 6 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 3.33712920 |
| 7 | Measles_Homo sapiens_hsa05162 | 2.98623659 |
| 8 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 2.10910115 |
| 9 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 2.02084786 |
| 10 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.98334982 |
| 11 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 1.95887140 |
| 12 | Allograft rejection_Homo sapiens_hsa05330 | 1.82571513 |
| 13 | Viral myocarditis_Homo sapiens_hsa05416 | 1.71515882 |
| 14 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 1.70367233 |
| 15 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 1.57002235 |
| 16 | Ribosome_Homo sapiens_hsa03010 | 1.50134154 |
| 17 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 1.47121923 |
| 18 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 1.45990830 |
| 19 | Osteoclast differentiation_Homo sapiens_hsa04380 | 1.45064864 |
| 20 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 1.42510240 |
| 21 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 1.37718950 |
| 22 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 1.34322845 |
| 23 | Leishmaniasis_Homo sapiens_hsa05140 | 1.31115714 |
| 24 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.29219636 |
| 25 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 1.29092710 |
| 26 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 1.23794305 |
| 27 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 1.23721928 |
| 28 | Herpes simplex infection_Homo sapiens_hsa05168 | 1.14015726 |
| 29 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 1.13569726 |
| 30 | Shigellosis_Homo sapiens_hsa05131 | 1.11950019 |
| 31 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 1.10304511 |
| 32 | HTLV-I infection_Homo sapiens_hsa05166 | 1.07832894 |
| 33 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 1.07322172 |
| 34 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 1.06496286 |
| 35 | Apoptosis_Homo sapiens_hsa04210 | 1.01604652 |
| 36 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.99149690 |
| 37 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.94702252 |
| 38 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.92054852 |
| 39 | Colorectal cancer_Homo sapiens_hsa05210 | 0.90397404 |
| 40 | Toxoplasmosis_Homo sapiens_hsa05145 | 0.90228561 |
| 41 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.89692448 |
| 42 | Parkinsons disease_Homo sapiens_hsa05012 | 0.89549103 |
| 43 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.88928360 |
| 44 | Hepatitis B_Homo sapiens_hsa05161 | 0.85654176 |
| 45 | RNA polymerase_Homo sapiens_hsa03020 | 0.84193480 |
| 46 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.81615687 |
| 47 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.79112734 |
| 48 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.79020043 |
| 49 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.77810263 |
| 50 | TNF signaling pathway_Homo sapiens_hsa04668 | 0.75931029 |
| 51 | Alzheimers disease_Homo sapiens_hsa05010 | 0.75182992 |
| 52 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.73420808 |
| 53 | Influenza A_Homo sapiens_hsa05164 | 0.72712991 |
| 54 | Platelet activation_Homo sapiens_hsa04611 | 0.72227888 |
| 55 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 0.71777725 |
| 56 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 0.67054473 |
| 57 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.66493806 |
| 58 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.65899332 |
| 59 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.63732008 |
| 60 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.62233476 |
| 61 | Tuberculosis_Homo sapiens_hsa05152 | 0.60080153 |
| 62 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.58464100 |
| 63 | Mismatch repair_Homo sapiens_hsa03430 | 0.58147884 |
| 64 | Legionellosis_Homo sapiens_hsa05134 | 0.57760554 |
| 65 | Salmonella infection_Homo sapiens_hsa05132 | 0.57409977 |
| 66 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.56873351 |
| 67 | Malaria_Homo sapiens_hsa05144 | 0.56473861 |
| 68 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.54948279 |
| 69 | Spliceosome_Homo sapiens_hsa03040 | 0.52560910 |
| 70 | Hepatitis C_Homo sapiens_hsa05160 | 0.51358547 |
| 71 | Endocytosis_Homo sapiens_hsa04144 | 0.51182919 |
| 72 | Proteasome_Homo sapiens_hsa03050 | 0.49033150 |
| 73 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.45550496 |
| 74 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.44749268 |
| 75 | DNA replication_Homo sapiens_hsa03030 | 0.42464631 |
| 76 | Huntingtons disease_Homo sapiens_hsa05016 | 0.41770671 |
| 77 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 0.41486717 |
| 78 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.40719979 |
| 79 | Pertussis_Homo sapiens_hsa05133 | 0.35873866 |
| 80 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.34696678 |
| 81 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.33027984 |
| 82 | Peroxisome_Homo sapiens_hsa04146 | 0.32832093 |
| 83 | Thyroid cancer_Homo sapiens_hsa05216 | 0.31607739 |
| 84 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.29162828 |
| 85 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.28466381 |
| 86 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.28119563 |
| 87 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.26356518 |
| 88 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.25869883 |
| 89 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.25833359 |
| 90 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.25832021 |
| 91 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.25560170 |
| 92 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 0.25155785 |
| 93 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.24897488 |
| 94 | Purine metabolism_Homo sapiens_hsa00230 | 0.23117085 |
| 95 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.22149717 |
| 96 | ABC transporters_Homo sapiens_hsa02010 | 0.21320614 |
| 97 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.20533837 |
| 98 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.20097654 |
| 99 | Insulin resistance_Homo sapiens_hsa04931 | 0.19830861 |
| 100 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.19792879 |
| 101 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.19717392 |
| 102 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.17706351 |
| 103 | Olfactory transduction_Homo sapiens_hsa04740 | 0.16127510 |
| 104 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.16036953 |
| 105 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.14942837 |
| 106 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 0.14667921 |
| 107 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.14327319 |
| 108 | Phagosome_Homo sapiens_hsa04145 | 0.14267446 |
| 109 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.13764108 |
| 110 | Asthma_Homo sapiens_hsa05310 | 0.13293570 |
| 111 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.12886032 |
| 112 | Adherens junction_Homo sapiens_hsa04520 | 0.11770817 |
| 113 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.10669898 |
| 114 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.10590397 |
| 115 | Prostate cancer_Homo sapiens_hsa05215 | 0.10527948 |
| 116 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.09996767 |
| 117 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.09772641 |
| 118 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.08925303 |
| 119 | Endometrial cancer_Homo sapiens_hsa05213 | 0.08726481 |
| 120 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.07384341 |
| 121 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.06989796 |
| 122 | Base excision repair_Homo sapiens_hsa03410 | 0.06791711 |
| 123 | RNA degradation_Homo sapiens_hsa03018 | 0.05984028 |
| 124 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.05648973 |
| 125 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.05022698 |
| 126 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.04795101 |
| 127 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.04436547 |
| 128 | Lysosome_Homo sapiens_hsa04142 | 0.03862310 |
| 129 | Prion diseases_Homo sapiens_hsa05020 | 0.03710513 |
| 130 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.02530066 |
| 131 | Gastric acid secretion_Homo sapiens_hsa04971 | 0.01444263 |

