

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 9.33951049 |
| 2 | pyrimidine ribonucleoside catabolic process (GO:0046133) | 9.32321548 |
| 3 | DNA deamination (GO:0045006) | 8.84516063 |
| 4 | negative T cell selection (GO:0043383) | 8.26364284 |
| 5 | positive regulation of gamma-delta T cell activation (GO:0046645) | 8.21904938 |
| 6 | negative regulation of leukocyte mediated cytotoxicity (GO:0001911) | 7.81006997 |
| 7 | negative regulation of cell killing (GO:0031342) | 7.81006997 |
| 8 | negative thymic T cell selection (GO:0045060) | 7.69531787 |
| 9 | regulation of isotype switching to IgG isotypes (GO:0048302) | 7.36733124 |
| 10 | positive regulation of antigen receptor-mediated signaling pathway (GO:0050857) | 6.73036185 |
| 11 | response to interleukin-15 (GO:0070672) | 6.71049782 |
| 12 | regulation of gamma-delta T cell differentiation (GO:0045586) | 6.68349379 |
| 13 | positive T cell selection (GO:0043368) | 6.50101178 |
| 14 | regulation of T cell tolerance induction (GO:0002664) | 6.35282471 |
| 15 | thymic T cell selection (GO:0045061) | 6.34870035 |
| 16 | positive thymic T cell selection (GO:0045059) | 6.33259787 |
| 17 | interferon-gamma production (GO:0032609) | 6.20111869 |
| 18 | T cell selection (GO:0045058) | 6.12729421 |
| 19 | positive regulation of interleukin-2 biosynthetic process (GO:0045086) | 6.10232832 |
| 20 | regulation of gamma-delta T cell activation (GO:0046643) | 5.97510411 |
| 21 | antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885) | 5.96070110 |
| 22 | antigen processing and presentation of endogenous peptide antigen (GO:0002483) | 5.96070110 |
| 23 | negative regulation by host of viral transcription (GO:0043922) | 5.92915314 |
| 24 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G | 5.92511334 |
| 25 | cellular response to interleukin-15 (GO:0071350) | 5.80628715 |
| 26 | eosinophil chemotaxis (GO:0048245) | 5.71297559 |
| 27 | T cell receptor signaling pathway (GO:0050852) | 5.52347051 |
| 28 | regulation of activation of Janus kinase activity (GO:0010533) | 5.51467020 |
| 29 | negative regulation of T cell apoptotic process (GO:0070233) | 5.51064190 |
| 30 | T cell costimulation (GO:0031295) | 5.39067486 |
| 31 | positive regulation of tolerance induction (GO:0002645) | 5.31235118 |
| 32 | lymphocyte costimulation (GO:0031294) | 5.29041757 |
| 33 | positive regulation of interleukin-8 secretion (GO:2000484) | 5.19970979 |
| 34 | activated T cell proliferation (GO:0050798) | 5.19301717 |
| 35 | eosinophil migration (GO:0072677) | 5.16498880 |
| 36 | Arp2/3 complex-mediated actin nucleation (GO:0034314) | 5.13127642 |
| 37 | macrophage chemotaxis (GO:0048246) | 5.12234361 |
| 38 | leukocyte aggregation (GO:0070486) | 5.12159116 |
| 39 | regulation of lymphocyte chemotaxis (GO:1901623) | 5.09787787 |
| 40 | T cell migration (GO:0072678) | 5.05264774 |
| 41 | regulation of chronic inflammatory response (GO:0002676) | 5.00974697 |
| 42 | antigen processing and presentation of endogenous antigen (GO:0019883) | 4.99535363 |
| 43 | regulation of alpha-beta T cell proliferation (GO:0046640) | 4.82413316 |
| 44 | positive regulation of T cell chemotaxis (GO:0010820) | 4.81317812 |
| 45 | regulation of T cell chemotaxis (GO:0010819) | 4.81317812 |
| 46 | pyrimidine nucleoside catabolic process (GO:0046135) | 4.73357233 |
| 47 | positive regulation of isotype switching (GO:0045830) | 4.72428521 |
| 48 | negative regulation of T cell mediated immunity (GO:0002710) | 4.69979817 |
| 49 | positive regulation of alpha-beta T cell proliferation (GO:0046641) | 4.65772903 |
| 50 | regulation of tolerance induction (GO:0002643) | 4.63471325 |
| 51 | antigen receptor-mediated signaling pathway (GO:0050851) | 4.60778080 |
| 52 | positive regulation of immunoglobulin mediated immune response (GO:0002891) | 4.58289925 |
| 53 | positive regulation of B cell mediated immunity (GO:0002714) | 4.58289925 |
| 54 | negative regulation of viral genome replication (GO:0045071) | 4.56062033 |
| 55 | regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923) | 4.54016262 |
| 56 | positive regulation of calcium-mediated signaling (GO:0050850) | 4.53593154 |
| 57 | regulation of T cell receptor signaling pathway (GO:0050856) | 4.52380199 |
| 58 | actin nucleation (GO:0045010) | 4.49567551 |
| 59 | positive regulation of monocyte chemotaxis (GO:0090026) | 4.38231892 |
| 60 | regulation of antigen receptor-mediated signaling pathway (GO:0050854) | 4.36408737 |
| 61 | regulation of natural killer cell mediated immunity (GO:0002715) | 4.35505743 |
| 62 | regulation of natural killer cell mediated cytotoxicity (GO:0042269) | 4.35505743 |
| 63 | regulation of interleukin-2 biosynthetic process (GO:0045076) | 4.22703519 |
| 64 | positive regulation of natural killer cell mediated cytotoxicity (GO:0045954) | 4.21616769 |
| 65 | positive regulation of natural killer cell mediated immunity (GO:0002717) | 4.21616769 |
| 66 | positive regulation of interleukin-2 production (GO:0032743) | 4.15409232 |
| 67 | monocyte chemotaxis (GO:0002548) | 4.14371431 |
| 68 | regulation of regulatory T cell differentiation (GO:0045589) | 4.11953787 |
| 69 | regulation of mononuclear cell migration (GO:0071675) | 4.11883999 |
| 70 | regulation of isotype switching (GO:0045191) | 4.11486861 |
| 71 | positive regulation of lymphocyte migration (GO:2000403) | 4.07292506 |
| 72 | regulation of immunoglobulin mediated immune response (GO:0002889) | 4.05316252 |
| 73 | regulation of B cell receptor signaling pathway (GO:0050855) | 4.04860919 |
| 74 | positive regulation of DNA recombination (GO:0045911) | 4.03042717 |
| 75 | positive regulation of T cell apoptotic process (GO:0070234) | 4.02503548 |
| 76 | mast cell activation (GO:0045576) | 3.99896336 |
| 77 | positive regulation of humoral immune response (GO:0002922) | 3.97958100 |
| 78 | positive regulation of B cell differentiation (GO:0045579) | 3.96802494 |
| 79 | regulation of macrophage chemotaxis (GO:0010758) | 3.94181559 |
| 80 | regulation of B cell mediated immunity (GO:0002712) | 3.93986713 |
| 81 | positive regulation of immunoglobulin production (GO:0002639) | 3.92039515 |
| 82 | regulation of chemokine-mediated signaling pathway (GO:0070099) | 3.91699119 |
| 83 | dendritic cell chemotaxis (GO:0002407) | 3.91117619 |
| 84 | cytolysis (GO:0019835) | 3.87094040 |
| 85 | T cell differentiation (GO:0030217) | 3.86167210 |
| 86 | alpha-beta T cell activation (GO:0046631) | 3.80408967 |
| 87 | regulation of interleukin-8 secretion (GO:2000482) | 3.79205128 |
| 88 | regulation of T cell apoptotic process (GO:0070232) | 3.76328611 |
| 89 | negative regulation of lymphocyte apoptotic process (GO:0070229) | 3.75908241 |
| 90 | regulation of response to interferon-gamma (GO:0060330) | 3.74678568 |
| 91 | positive regulation of T cell mediated cytotoxicity (GO:0001916) | 3.72155135 |
| 92 | positive regulation of interleukin-4 production (GO:0032753) | 3.71645555 |
| 93 | positive regulation of translational initiation (GO:0045948) | 3.71466400 |
| 94 | regulation of leukocyte mediated cytotoxicity (GO:0001910) | 3.71368661 |
| 95 | positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523) | 3.69971952 |
| 96 | negative regulation of lymphocyte mediated immunity (GO:0002707) | 3.68887116 |
| 97 | positive regulation of leukocyte mediated cytotoxicity (GO:0001912) | 3.63789157 |
| 98 | positive regulation of T cell cytokine production (GO:0002726) | 3.63702040 |
| 99 | regulation of interferon-gamma-mediated signaling pathway (GO:0060334) | 3.63665511 |
| 100 | regulation of immunoglobulin production (GO:0002637) | 3.63158551 |
| 101 | alpha-beta T cell differentiation (GO:0046632) | 3.61545603 |
| 102 | V(D)J recombination (GO:0033151) | 3.59277503 |
| 103 | negative regulation of calcium ion transport into cytosol (GO:0010523) | 3.56572574 |
| 104 | regulation of T cell mediated cytotoxicity (GO:0001914) | 3.55551458 |
| 105 | positive regulation of immune response to tumor cell (GO:0002839) | 3.55278740 |
| 106 | regulation of immune response to tumor cell (GO:0002837) | 3.55278740 |
| 107 | regulation of response to tumor cell (GO:0002834) | 3.55278740 |
| 108 | positive regulation of response to tumor cell (GO:0002836) | 3.55278740 |
| 109 | T cell activation (GO:0042110) | 3.53589573 |
| 110 | sequestering of actin monomers (GO:0042989) | 3.53282858 |
| 111 | negative regulation of T cell receptor signaling pathway (GO:0050860) | 3.47031695 |
| 112 | lymphocyte migration (GO:0072676) | 3.46678038 |
| 113 | T cell proliferation (GO:0042098) | 3.44807808 |
| 114 | regulation of cell killing (GO:0031341) | 3.44692056 |
| 115 | regulation of interleukin-12 biosynthetic process (GO:0045075) | 3.44426956 |
| 116 | cellular response to interleukin-4 (GO:0071353) | 3.44060715 |
| 117 | negative regulation of B cell proliferation (GO:0030889) | 3.41153507 |
| 118 | natural killer cell activation (GO:0030101) | 3.39948834 |
| 119 | positive regulation of cell killing (GO:0031343) | 3.36644438 |
| 120 | regulation of lymphocyte migration (GO:2000401) | 3.33017215 |
| 121 | T cell homeostasis (GO:0043029) | 3.31380466 |
| 122 | negative regulation of antigen receptor-mediated signaling pathway (GO:0050858) | 3.30151508 |
| 123 | dendritic cell migration (GO:0036336) | 3.29158086 |
| 124 | positive regulation of interleukin-1 beta secretion (GO:0050718) | 3.29058071 |
| 125 | regulation of oxidative stress-induced neuron death (GO:1903203) | 3.29025788 |
| 126 | regulation of calcium-mediated signaling (GO:0050848) | 3.28046243 |
| 127 | modulation by host of viral transcription (GO:0043921) | 3.24321082 |
| 128 | modulation by host of symbiont transcription (GO:0052472) | 3.24321082 |
| 129 | positive regulation of T cell migration (GO:2000406) | 3.23529122 |
| 130 | angiogenesis involved in wound healing (GO:0060055) | 3.22537981 |
| 131 | regulation of viral genome replication (GO:0045069) | 3.22413480 |
| 132 | regulation of interleukin-2 production (GO:0032663) | 3.22284078 |
| 133 | immune response-activating cell surface receptor signaling pathway (GO:0002429) | 3.21893875 |
| 134 | positive regulation of lymphocyte mediated immunity (GO:0002708) | 3.19271601 |
| 135 | negative regulation of stress fiber assembly (GO:0051497) | 3.19039152 |
| 136 | response to interleukin-4 (GO:0070670) | 3.15739987 |
| 137 | modulation of transcription in other organism involved in symbiotic interaction (GO:0052312) | 3.13585587 |
| 138 | antigen processing and presentation via MHC class Ib (GO:0002475) | 3.12726565 |
| 139 | regulation of B cell differentiation (GO:0045577) | 3.12499792 |
| 140 | mast cell activation involved in immune response (GO:0002279) | 3.12411129 |
| 141 | mast cell degranulation (GO:0043303) | 3.12411129 |
| 142 | regulation of interleukin-1 beta secretion (GO:0050706) | 3.12062321 |
| 143 | regulation of lymphocyte mediated immunity (GO:0002706) | 3.10754582 |
| 144 | positive regulation of interleukin-1 secretion (GO:0050716) | 3.10728412 |
| 145 | negative regulation of viral transcription (GO:0032897) | 3.10296848 |
| 146 | regulation of defense response to virus by virus (GO:0050690) | 3.10086223 |
| 147 | positive regulation of T cell activation (GO:0050870) | 3.09966666 |
| 148 | natural killer cell differentiation (GO:0001779) | 3.07739948 |
| 149 | leukocyte cell-cell adhesion (GO:0007159) | 3.03366579 |
| 150 | signal complex assembly (GO:0007172) | 3.02503147 |
| 151 | ribosomal small subunit assembly (GO:0000028) | 3.01762213 |
| 152 | regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522) | 3.00458122 |
| 153 | heterotypic cell-cell adhesion (GO:0034113) | 2.99314320 |
| 154 | myeloid dendritic cell activation (GO:0001773) | 2.98682832 |
| 155 | cytidine deamination (GO:0009972) | 10.4456223 |
| 156 | cytidine metabolic process (GO:0046087) | 10.4456223 |
| 157 | cytidine catabolic process (GO:0006216) | 10.4456223 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 8.25150707 |
| 2 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 6.52722871 |
| 3 | RUNX_20019798_ChIP-Seq_JUKART_Human | 4.42190037 |
| 4 | E2F7_22180533_ChIP-Seq_HELA_Human | 4.19834796 |
| 5 | STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 3.88827092 |
| 6 | FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse | 3.70188043 |
| 7 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 3.65348769 |
| 8 | MYB_26560356_Chip-Seq_TH2_Human | 3.46452641 |
| 9 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 3.40323997 |
| 10 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 3.28641593 |
| 11 | MYC_22102868_ChIP-Seq_BL_Human | 3.27651413 |
| 12 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 3.22976887 |
| 13 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 3.18017130 |
| 14 | MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 3.09869299 |
| 15 | MAF_26560356_Chip-Seq_TH1_Human | 3.06336298 |
| 16 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 3.03139466 |
| 17 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 2.75703361 |
| 18 | UTX_26944678_Chip-Seq_JUKART_Human | 2.72079521 |
| 19 | MYB_26560356_Chip-Seq_TH1_Human | 2.70086131 |
| 20 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 2.53951380 |
| 21 | GATA3_27048872_Chip-Seq_THYMUS_Human | 2.33252932 |
| 22 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 2.24832457 |
| 23 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 2.24041536 |
| 24 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 2.21869185 |
| 25 | KDM2B_26808549_Chip-Seq_HPB-ALL_Human | 2.18138707 |
| 26 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 2.17644693 |
| 27 | CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human | 2.16275270 |
| 28 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 2.14468601 |
| 29 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 2.04242897 |
| 30 | MAF_26560356_Chip-Seq_TH2_Human | 2.03048100 |
| 31 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 2.02473014 |
| 32 | VDR_21846776_ChIP-Seq_THP-1_Human | 1.98960083 |
| 33 | RUNX1_22412390_ChIP-Seq_EML_Mouse | 1.95879047 |
| 34 | SCL_19346495_ChIP-Seq_HPC-7_Human | 1.88458252 |
| 35 | NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse | 1.87877005 |
| 36 | RUNX1_17652178_ChIP-ChIP_JURKAT_Human | 1.87461871 |
| 37 | IRF8_27001747_Chip-Seq_BMDM_Mouse | 1.84799045 |
| 38 | SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse | 1.82464896 |
| 39 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 1.81964055 |
| 40 | SPI1_23547873_ChIP-Seq_NB4_Human | 1.80931142 |
| 41 | TCF7_22412390_ChIP-Seq_EML_Mouse | 1.78643195 |
| 42 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.77874908 |
| 43 | VDR_22108803_ChIP-Seq_LS180_Human | 1.76727813 |
| 44 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 1.76452602 |
| 45 | E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 1.76009703 |
| 46 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 1.71249621 |
| 47 | KDM2B_26808549_Chip-Seq_DND41_Human | 1.66141092 |
| 48 | SPI1_23127762_ChIP-Seq_K562_Human | 1.64831218 |
| 49 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.55169263 |
| 50 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.52820406 |
| 51 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 1.50921135 |
| 52 | VDR_24763502_ChIP-Seq_THP-1_Human | 1.49900729 |
| 53 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 1.49683336 |
| 54 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.43293279 |
| 55 | TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.43231250 |
| 56 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.34937651 |
| 57 | BRD4_27068464_Chip-Seq_AML-cells_Mouse | 1.34096820 |
| 58 | GATA3_26560356_Chip-Seq_TH2_Human | 1.28940901 |
| 59 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.28658673 |
| 60 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.28421751 |
| 61 | KDM2B_26808549_Chip-Seq_JURKAT_Human | 1.27316198 |
| 62 | PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.26751743 |
| 63 | HTT_18923047_ChIP-ChIP_STHdh_Human | 1.25394879 |
| 64 | RBPJ_21746931_ChIP-Seq_IB4-LCL_Human | 1.21552314 |
| 65 | PU_27001747_Chip-Seq_BMDM_Mouse | 1.20217477 |
| 66 | MEIS1_20887958_ChIP-Seq_HPC-7_Mouse | 1.19403107 |
| 67 | TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse | 1.19244424 |
| 68 | PBX1_22567123_ChIP-ChIP_OVCAR3_Human | 1.18500138 |
| 69 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.17664518 |
| 70 | GATA2_22383799_ChIP-Seq_G1ME_Mouse | 1.16721455 |
| 71 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 1.16452944 |
| 72 | BCL6_27268052_Chip-Seq_Bcells_Human | 1.16392113 |
| 73 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 1.14314097 |
| 74 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 1.10794394 |
| 75 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 1.09681151 |
| 76 | VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human | 1.07359542 |
| 77 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 1.05451757 |
| 78 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.00896493 |
| 79 | TAF2_19829295_ChIP-Seq_ESCs_Human | 1.00611312 |
| 80 | VDR_23849224_ChIP-Seq_CD4+_Human | 0.99899697 |
| 81 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 0.99447758 |
| 82 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 0.98958061 |
| 83 | FOXP3_21729870_ChIP-Seq_TREG_Human | 0.98604312 |
| 84 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 0.97829133 |
| 85 | P300_27268052_Chip-Seq_Bcells_Human | 0.96927848 |
| 86 | CTCF_20526341_ChIP-Seq_ESCs_Human | 0.95216282 |
| 87 | LMO2_20887958_ChIP-Seq_HPC-7_Mouse | 0.95157803 |
| 88 | GATA6_21074721_ChIP-Seq_CACO-2_Mouse | 0.94934919 |
| 89 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 0.94697646 |
| 90 | BMI1_19503595_ChIP-Seq_MEFsC_Mouse | 0.93677793 |
| 91 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 0.93610856 |
| 92 | TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.91801362 |
| 93 | PU.1_20513432_ChIP-Seq_Bcells_Mouse | 0.91721512 |
| 94 | CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse | 0.91114652 |
| 95 | SA1_27219007_Chip-Seq_Bcells_Human | 0.90847920 |
| 96 | YY1_22570637_ChIP-Seq_MALME-3M_Human | 0.89914571 |
| 97 | CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse | 0.89747849 |
| 98 | BCOR_27268052_Chip-Seq_Bcells_Human | 0.89643250 |
| 99 | NANOG_20526341_ChIP-Seq_ESCs_Human | 0.88645362 |
| 100 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 0.88509561 |
| 101 | ELK1_19687146_ChIP-ChIP_HELA_Human | 0.88459403 |
| 102 | GATA3_26560356_Chip-Seq_TH1_Human | 0.88269667 |
| 103 | CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 0.87843415 |
| 104 | GATA1_22383799_ChIP-Seq_G1ME_Mouse | 0.87134703 |
| 105 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 0.85898439 |
| 106 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 0.85118483 |
| 107 | GATA6_21074721_ChIP-Seq_CACO-2_Human | 0.84290017 |
| 108 | BCAT_22108803_ChIP-Seq_LS180_Human | 0.84274788 |
| 109 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 0.83751328 |
| 110 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 0.82822191 |
| 111 | E2F1_20622854_ChIP-Seq_HELA_Human | 0.82195047 |
| 112 | EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human | 0.81481154 |
| 113 | RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.81467514 |
| 114 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 0.80937077 |
| 115 | GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.80186776 |
| 116 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.80016116 |
| 117 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 0.76972379 |
| 118 | RXR_22108803_ChIP-Seq_LS180_Human | 0.76151874 |
| 119 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 0.75546451 |
| 120 | RBPJ_21746931_ChIP-Seq_IB4_Human | 0.74985254 |
| 121 | EZH2_22144423_ChIP-Seq_EOC_Human | 0.74902422 |
| 122 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.74504916 |
| 123 | SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human | 0.73689454 |
| 124 | CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse | 0.73134074 |
| 125 | FOXH1_21741376_ChIP-Seq_EPCs_Human | 0.72453945 |
| 126 | P63_20808887_ChIP-Seq_KERATINOCYTES_Human | 0.71724492 |
| 127 | GATA2_19941826_ChIP-Seq_K562_Human | 0.71296111 |
| 128 | GATA1_19941826_ChIP-Seq_K562_Human | 0.70491552 |
| 129 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 0.69892908 |
| 130 | GATA2_20887958_ChIP-Seq_HPC-7_Mouse | 0.69469378 |
| 131 | CDX2_21074721_ChIP-Seq_CACO-2_Mouse | 0.69265302 |
| 132 | TP53_22573176_ChIP-Seq_HFKS_Human | 0.69105717 |
| 133 | AR_20517297_ChIP-Seq_VCAP_Human | 0.68136852 |
| 134 | FOXH1_21741376_ChIP-Seq_ESCs_Human | 0.66844201 |
| 135 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.66828483 |
| 136 | VDR_24787735_ChIP-Seq_THP-1_Human | 0.66651036 |
| 137 | GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.66625378 |
| 138 | NCOR1_26117541_ChIP-Seq_K562_Human | 0.64893970 |
| 139 | KDM5A_27292631_Chip-Seq_BREAST_Human | 0.63608635 |
| 140 | PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse | 0.62914739 |
| 141 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 0.62238605 |
| 142 | XRN2_22483619_ChIP-Seq_HELA_Human | 0.61618140 |
| 143 | RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.60125312 |
| 144 | ELF5_23300383_ChIP-Seq_T47D_Human | 0.58690849 |
| 145 | SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 0.58530507 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003763_abnormal_thymus_physiology | 5.55043813 |
| 2 | MP0005671_abnormal_response_to | 4.74877423 |
| 3 | MP0001835_abnormal_antigen_presentation | 3.87327212 |
| 4 | MP0000685_abnormal_immune_system | 3.84956090 |
| 5 | MP0001800_abnormal_humoral_immune | 3.56521664 |
| 6 | MP0002398_abnormal_bone_marrow | 3.12263777 |
| 7 | MP0000703_abnormal_thymus_morphology | 3.07867583 |
| 8 | MP0002420_abnormal_adaptive_immunity | 3.01663561 |
| 9 | MP0001819_abnormal_immune_cell | 2.97068381 |
| 10 | MP0009333_abnormal_splenocyte_physiolog | 2.96869156 |
| 11 | MP0002723_abnormal_immune_serum | 2.89679840 |
| 12 | MP0001790_abnormal_immune_system | 2.80710721 |
| 13 | MP0005387_immune_system_phenotype | 2.80710721 |
| 14 | MP0005000_abnormal_immune_tolerance | 2.79778966 |
| 15 | MP0002396_abnormal_hematopoietic_system | 2.75974306 |
| 16 | MP0002452_abnormal_antigen_presenting | 2.72195914 |
| 17 | MP0000716_abnormal_immune_system | 2.64815791 |
| 18 | MP0003300_gastrointestinal_ulcer | 2.64087992 |
| 19 | MP0002405_respiratory_system_inflammati | 2.54259402 |
| 20 | MP0002166_altered_tumor_susceptibility | 2.53593609 |
| 21 | MP0002722_abnormal_immune_system | 2.53080927 |
| 22 | MP0005025_abnormal_response_to | 2.42364814 |
| 23 | MP0000689_abnormal_spleen_morphology | 2.35682633 |
| 24 | MP0006082_CNS_inflammation | 2.30989550 |
| 25 | MP0003436_decreased_susceptibility_to | 2.28440594 |
| 26 | MP0010155_abnormal_intestine_physiology | 2.27789105 |
| 27 | MP0002429_abnormal_blood_cell | 2.19075785 |
| 28 | MP0003724_increased_susceptibility_to | 2.17558889 |
| 29 | MP0009785_altered_susceptibility_to | 2.16607263 |
| 30 | MP0004947_skin_inflammation | 2.07956645 |
| 31 | MP0002006_tumorigenesis | 2.05449859 |
| 32 | MP0002148_abnormal_hypersensitivity_rea | 2.05103417 |
| 33 | MP0001873_stomach_inflammation | 1.92633877 |
| 34 | MP0003866_abnormal_defecation | 1.88079461 |
| 35 | MP0002419_abnormal_innate_immunity | 1.86281944 |
| 36 | MP0005464_abnormal_platelet_physiology | 1.82699354 |
| 37 | MP0002163_abnormal_gland_morphology | 1.70114970 |
| 38 | MP0001845_abnormal_inflammatory_respons | 1.68276460 |
| 39 | MP0000858_altered_metastatic_potential | 1.65985347 |
| 40 | MP0002277_abnormal_respiratory_mucosa | 1.63046191 |
| 41 | MP0004808_abnormal_hematopoietic_stem | 1.55884649 |
| 42 | MP0004381_abnormal_hair_follicle | 1.55138536 |
| 43 | MP0003878_abnormal_ear_physiology | 1.48850482 |
| 44 | MP0005377_hearing/vestibular/ear_phenot | 1.48850482 |
| 45 | MP0002933_joint_inflammation | 1.47228140 |
| 46 | MP0000465_gastrointestinal_hemorrhage | 1.42999868 |
| 47 | MP0003786_premature_aging | 1.42494309 |
| 48 | MP0001853_heart_inflammation | 1.35995879 |
| 49 | MP0002132_abnormal_respiratory_system | 1.33146099 |
| 50 | MP0002877_abnormal_melanocyte_morpholog | 1.30735117 |
| 51 | MP0003303_peritoneal_inflammation | 1.30207705 |
| 52 | MP0002138_abnormal_hepatobiliary_system | 1.28741219 |
| 53 | MP0001919_abnormal_reproductive_system | 1.27854994 |
| 54 | MP0003448_altered_tumor_morphology | 1.25792733 |
| 55 | MP0008961_abnormal_basal_metabolism | 1.23004176 |
| 56 | MP0009379_abnormal_foot_pigmentation | 1.20864958 |
| 57 | MP0002009_preneoplasia | 1.14838372 |
| 58 | MP0001188_hyperpigmentation | 1.09586182 |
| 59 | MP0005645_abnormal_hypothalamus_physiol | 1.09028257 |
| 60 | MP0002019_abnormal_tumor_incidence | 1.08733686 |
| 61 | MP0005075_abnormal_melanosome_morpholog | 1.06871690 |
| 62 | MP0003045_fibrosis | 1.05585207 |
| 63 | MP0000490_abnormal_crypts_of | 1.05584402 |
| 64 | MP0002876_abnormal_thyroid_physiology | 1.05339240 |
| 65 | MP0001851_eye_inflammation | 1.05289341 |
| 66 | MP0005257_abnormal_intraocular_pressure | 1.03949540 |
| 67 | MP0002693_abnormal_pancreas_physiology | 1.03056531 |
| 68 | MP0004185_abnormal_adipocyte_glucose | 1.01633416 |
| 69 | MP0010352_gastrointestinal_tract_polyps | 1.00679117 |
| 70 | MP0001533_abnormal_skeleton_physiology | 0.99039131 |
| 71 | MP0008872_abnormal_physiological_respon | 0.98791863 |
| 72 | MP0010307_abnormal_tumor_latency | 0.98141303 |
| 73 | MP0008469_abnormal_protein_level | 0.96869010 |
| 74 | MP0001905_abnormal_dopamine_level | 0.94902029 |
| 75 | MP0003137_abnormal_impulse_conducting | 0.92656096 |
| 76 | MP0004134_abnormal_chest_morphology | 0.89885432 |
| 77 | MP0005076_abnormal_cell_differentiation | 0.88798313 |
| 78 | MP0004145_abnormal_muscle_electrophysio | 0.88291577 |
| 79 | MP0005379_endocrine/exocrine_gland_phen | 0.86669494 |
| 80 | MP0005310_abnormal_salivary_gland | 0.83724096 |
| 81 | MP0004510_myositis | 0.82412761 |
| 82 | MP0005023_abnormal_wound_healing | 0.81637281 |
| 83 | MP0000604_amyloidosis | 0.80911673 |
| 84 | MP0006054_spinal_hemorrhage | 0.80585160 |
| 85 | MP0008057_abnormal_DNA_replication | 0.80581115 |
| 86 | MP0001663_abnormal_digestive_system | 0.80075556 |
| 87 | MP0009765_abnormal_xenobiotic_induced | 0.79227516 |
| 88 | MP0005397_hematopoietic_system_phenotyp | 0.77839496 |
| 89 | MP0001545_abnormal_hematopoietic_system | 0.77839496 |
| 90 | MP0010094_abnormal_chromosome_stability | 0.76546643 |
| 91 | MP0000372_irregular_coat_pigmentation | 0.73885930 |
| 92 | MP0003077_abnormal_cell_cycle | 0.73640991 |
| 93 | MP0003075_altered_response_to | 0.73268654 |
| 94 | MP0001485_abnormal_pinna_reflex | 0.71406358 |
| 95 | MP0001958_emphysema | 0.68803725 |
| 96 | MP0001765_abnormal_ion_homeostasis | 0.67964491 |
| 97 | MP0002909_abnormal_adrenal_gland | 0.66663426 |
| 98 | MP0005166_decreased_susceptibility_to | 0.66344372 |
| 99 | MP0001348_abnormal_lacrimal_gland | 0.64662104 |
| 100 | MP0003567_abnormal_fetal_cardiomyocyte | 0.63345343 |
| 101 | MP0003011_delayed_dark_adaptation | 0.63184448 |
| 102 | MP0000609_abnormal_liver_physiology | 0.62416120 |
| 103 | MP0005389_reproductive_system_phenotype | 0.60624719 |
| 104 | MP0002998_abnormal_bone_remodeling | 0.60350540 |
| 105 | MP0001501_abnormal_sleep_pattern | 0.58685355 |
| 106 | MP0009763_increased_sensitivity_to | 0.58477610 |
| 107 | MP0001542_abnormal_bone_strength | 0.58450211 |
| 108 | MP0002095_abnormal_skin_pigmentation | 0.57263567 |
| 109 | MP0005636_abnormal_mineral_homeostasis | 0.57110928 |
| 110 | MP0006035_abnormal_mitochondrial_morpho | 0.56809048 |
| 111 | MP0009764_decreased_sensitivity_to | 0.56383346 |
| 112 | MP0004957_abnormal_blastocyst_morpholog | 0.56162339 |
| 113 | MP0004130_abnormal_muscle_cell | 0.55560475 |
| 114 | MP0003806_abnormal_nucleotide_metabolis | 0.55339908 |
| 115 | MP0009643_abnormal_urine_homeostasis | 0.54741807 |
| 116 | MP0008007_abnormal_cellular_replicative | 0.53059395 |
| 117 | MP0005360_urolithiasis | 0.52451367 |
| 118 | MP0005551_abnormal_eye_electrophysiolog | 0.51713550 |
| 119 | MP0005330_cardiomyopathy | 0.51576045 |
| 120 | MP0006036_abnormal_mitochondrial_physio | 0.51323142 |
| 121 | MP0008873_increased_physiological_sensi | 0.50805739 |
| 122 | MP0000477_abnormal_intestine_morphology | 0.48557913 |
| 123 | MP0003111_abnormal_nucleus_morphology | 0.47761810 |
| 124 | MP0003795_abnormal_bone_structure | 0.47265211 |
| 125 | MP0000350_abnormal_cell_proliferation | 0.46688377 |
| 126 | MP0002136_abnormal_kidney_physiology | 0.45727392 |
| 127 | MP0001661_extended_life_span | 0.44304099 |
| 128 | MP0005670_abnormal_white_adipose | 0.43744571 |
| 129 | MP0003693_abnormal_embryo_hatching | 0.42822443 |
| 130 | MP0000249_abnormal_blood_vessel | 0.42083641 |
| 131 | MP0003453_abnormal_keratinocyte_physiol | 0.42073872 |
| 132 | MP0005666_abnormal_adipose_tissue | 0.41842655 |
| 133 | MP0003279_aneurysm | 0.41298875 |
| 134 | MP0000920_abnormal_myelination | 0.41147955 |
| 135 | MP0003943_abnormal_hepatobiliary_system | 0.40924521 |
| 136 | MP0004233_abnormal_muscle_weight | 0.40564237 |
| 137 | MP0000627_abnormal_mammary_gland | 0.39606363 |
| 138 | MP0000013_abnormal_adipose_tissue | 0.39559334 |
| 139 | MP0003656_abnormal_erythrocyte_physiolo | 0.39055919 |
| 140 | MP0002083_premature_death | 0.38543463 |
| 141 | MP0002970_abnormal_white_adipose | 0.37614364 |
| 142 | MP0003091_abnormal_cell_migration | 0.37287270 |
| 143 | MP0005174_abnormal_tail_pigmentation | 0.36605671 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | T lymphocytopenia (HP:0005403) | 8.74013711 |
| 2 | Abnormality of T cell number (HP:0011839) | 8.36020586 |
| 3 | Elevated erythrocyte sedimentation rate (HP:0003565) | 5.78283769 |
| 4 | Abnormality of T cells (HP:0002843) | 5.58267503 |
| 5 | Severe combined immunodeficiency (HP:0004430) | 5.28780838 |
| 6 | Combined immunodeficiency (HP:0005387) | 5.28542097 |
| 7 | Recurrent viral infections (HP:0004429) | 5.07883817 |
| 8 | Hypoproteinemia (HP:0003075) | 4.94012068 |
| 9 | Nasal polyposis (HP:0100582) | 4.76168695 |
| 10 | Panhypogammaglobulinemia (HP:0003139) | 4.60174711 |
| 11 | Autoimmune hemolytic anemia (HP:0001890) | 4.43191470 |
| 12 | Recurrent fungal infections (HP:0002841) | 4.30697785 |
| 13 | Recurrent bronchitis (HP:0002837) | 4.29862581 |
| 14 | IgG deficiency (HP:0004315) | 4.24082510 |
| 15 | Stomatitis (HP:0010280) | 4.20396156 |
| 16 | Aplastic anemia (HP:0001915) | 4.20385775 |
| 17 | Eosinophilia (HP:0001880) | 4.19189871 |
| 18 | Abnormality of eosinophils (HP:0001879) | 4.18808204 |
| 19 | Chronic otitis media (HP:0000389) | 4.05120044 |
| 20 | Abnormality of the nasal mucosa (HP:0000433) | 3.93602958 |
| 21 | Stomach cancer (HP:0012126) | 3.92231250 |
| 22 | Myositis (HP:0100614) | 3.79390767 |
| 23 | IgM deficiency (HP:0002850) | 3.76290326 |
| 24 | Thyroiditis (HP:0100646) | 3.74164585 |
| 25 | Abnormality of macrophages (HP:0004311) | 3.63882072 |
| 26 | Abnormal delayed hypersensitivity skin test (HP:0002963) | 3.58987186 |
| 27 | B lymphocytopenia (HP:0010976) | 3.58540185 |
| 28 | Abnormality of B cell number (HP:0010975) | 3.58540185 |
| 29 | Leukocytosis (HP:0001974) | 3.56295761 |
| 30 | Pustule (HP:0200039) | 3.54553299 |
| 31 | Granulocytopenia (HP:0001913) | 3.51117735 |
| 32 | Chronic mucocutaneous candidiasis (HP:0002728) | 3.44434092 |
| 33 | Recurrent cutaneous fungal infections (HP:0011370) | 3.44434092 |
| 34 | Chronic diarrhea (HP:0002028) | 3.37917912 |
| 35 | Abnormality of the prostate (HP:0008775) | 3.34279810 |
| 36 | Joint swelling (HP:0001386) | 3.30508016 |
| 37 | Hemiplegia (HP:0002301) | 3.12567682 |
| 38 | Eczematoid dermatitis (HP:0000976) | 3.09896229 |
| 39 | Lymphopenia (HP:0001888) | 3.09798920 |
| 40 | Agammaglobulinemia (HP:0004432) | 3.03260191 |
| 41 | Volvulus (HP:0002580) | 2.99304585 |
| 42 | Hypoplasia of the thymus (HP:0000778) | 2.98395275 |
| 43 | Abnormality of cells of the lymphoid lineage (HP:0012140) | 2.98102578 |
| 44 | Gangrene (HP:0100758) | 2.91848577 |
| 45 | Abnormality of T cell physiology (HP:0011840) | 2.91107820 |
| 46 | Abnormality of the fingertips (HP:0001211) | 2.89785591 |
| 47 | Hypoalbuminemia (HP:0003073) | 2.88594711 |
| 48 | Abnormal albumin level (HP:0012116) | 2.88594711 |
| 49 | Thrombocytosis (HP:0001894) | 2.87923772 |
| 50 | Alveolar cell carcinoma (HP:0006519) | 2.87241673 |
| 51 | Toxemia of pregnancy (HP:0100603) | 2.84313027 |
| 52 | Meningitis (HP:0001287) | 2.83534552 |
| 53 | Verrucae (HP:0200043) | 2.76566654 |
| 54 | Papilloma (HP:0012740) | 2.76566654 |
| 55 | Increased IgM level (HP:0003496) | 2.75655750 |
| 56 | Keratoconjunctivitis (HP:0001096) | 2.74597723 |
| 57 | Ureteral stenosis (HP:0000071) | 2.73224386 |
| 58 | Neoplasm of the tracheobronchial system (HP:0100552) | 2.69241972 |
| 59 | Encephalitis (HP:0002383) | 2.66039815 |
| 60 | 3-Methylglutaconic aciduria (HP:0003535) | 2.64710840 |
| 61 | Abnormality of the pleura (HP:0002103) | 2.63521741 |
| 62 | Autoimmune thrombocytopenia (HP:0001973) | 2.63260170 |
| 63 | Colon cancer (HP:0003003) | 2.59275378 |
| 64 | Inflammation of the large intestine (HP:0002037) | 2.54173646 |
| 65 | Recurrent abscess formation (HP:0002722) | 2.51055408 |
| 66 | Lymphoma (HP:0002665) | 2.50583307 |
| 67 | Basal cell carcinoma (HP:0002671) | 2.50570523 |
| 68 | Pulmonary embolism (HP:0002204) | 2.50103367 |
| 69 | Mediastinal lymphadenopathy (HP:0100721) | 2.50002875 |
| 70 | Recurrent sinusitis (HP:0011108) | 2.49367993 |
| 71 | Ureteral obstruction (HP:0006000) | 2.47324810 |
| 72 | Gastrointestinal inflammation (HP:0004386) | 2.46514489 |
| 73 | Spontaneous hematomas (HP:0007420) | 2.44933499 |
| 74 | Bronchitis (HP:0012387) | 2.43398298 |
| 75 | Easy fatigability (HP:0003388) | 2.42916533 |
| 76 | Congenital stationary night blindness (HP:0007642) | 2.42624361 |
| 77 | Recurrent skin infections (HP:0001581) | 2.38031921 |
| 78 | Amyotrophic lateral sclerosis (HP:0007354) | 2.37801261 |
| 79 | Hypochromic anemia (HP:0001931) | 2.32385492 |
| 80 | Attenuation of retinal blood vessels (HP:0007843) | 2.28444282 |
| 81 | Absent rod-and cone-mediated responses on ERG (HP:0007688) | 2.26300145 |
| 82 | Gastrointestinal infarctions (HP:0005244) | 2.21322805 |
| 83 | Tetraplegia (HP:0002445) | 2.20361723 |
| 84 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 2.17788236 |
| 85 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 2.17788236 |
| 86 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 2.17673368 |
| 87 | Recurrent otitis media (HP:0000403) | 2.17345792 |
| 88 | IgA deficiency (HP:0002720) | 2.15395909 |
| 89 | Mitochondrial inheritance (HP:0001427) | 2.14736321 |
| 90 | Cutis marmorata (HP:0000965) | 2.13797930 |
| 91 | Disinhibition (HP:0000734) | 2.13508023 |
| 92 | Hypergammaglobulinemia (HP:0010702) | 2.13242770 |
| 93 | Severe visual impairment (HP:0001141) | 2.13200965 |
| 94 | Colitis (HP:0002583) | 2.09717695 |
| 95 | Vasculitis (HP:0002633) | 2.04776599 |
| 96 | Abnormality of the pericardium (HP:0001697) | 2.03101412 |
| 97 | Keratitis (HP:0000491) | 2.02741863 |
| 98 | Recurrent bacterial skin infections (HP:0005406) | 2.02703675 |
| 99 | Striae distensae (HP:0001065) | 2.02036176 |
| 100 | Pulmonary infiltrates (HP:0002113) | 2.00181829 |
| 101 | Abnormality of oral frenula (HP:0000190) | 2.00144947 |
| 102 | Epistaxis (HP:0000421) | 1.99448387 |
| 103 | Increased IgE level (HP:0003212) | 1.99368217 |
| 104 | Abnormality of male internal genitalia (HP:0000022) | 1.98295797 |
| 105 | Chronic sinusitis (HP:0011109) | 1.96637720 |
| 106 | Renal cortical cysts (HP:0000803) | 1.95800610 |
| 107 | Hepatocellular necrosis (HP:0001404) | 1.95711476 |
| 108 | Abnormal platelet volume (HP:0011876) | 1.94015556 |
| 109 | Abnormality of the alveolar ridges (HP:0006477) | 1.93448321 |
| 110 | Acute hepatic failure (HP:0006554) | 1.92020719 |
| 111 | Optic neuritis (HP:0100653) | 1.89856229 |
| 112 | Retrobulbar optic neuritis (HP:0100654) | 1.89856229 |
| 113 | Bicuspid aortic valve (HP:0001647) | 1.89541775 |
| 114 | Obstructive lung disease (HP:0006536) | 1.88501864 |
| 115 | Chronic obstructive pulmonary disease (HP:0006510) | 1.88501864 |
| 116 | Acute necrotizing encephalopathy (HP:0006965) | 1.85413105 |
| 117 | Orchitis (HP:0100796) | 1.85320664 |
| 118 | Glomerulopathy (HP:0100820) | 1.84479715 |
| 119 | Hyponatremia (HP:0002902) | 1.84100550 |
| 120 | Amaurosis fugax (HP:0100576) | 1.84063635 |
| 121 | Oral leukoplakia (HP:0002745) | 1.82068119 |
| 122 | Hemoptysis (HP:0002105) | 1.81959289 |
| 123 | Keratoconjunctivitis sicca (HP:0001097) | 1.80885544 |
| 124 | Carpal bone hypoplasia (HP:0001498) | 1.79627649 |
| 125 | Broad palm (HP:0001169) | 1.78296936 |
| 126 | Increased CSF protein (HP:0002922) | 1.77716936 |
| 127 | Type 2 muscle fiber atrophy (HP:0003554) | 1.76944972 |
| 128 | Muscle fiber atrophy (HP:0100295) | 1.76882616 |
| 129 | Urticaria (HP:0001025) | 1.76492380 |
| 130 | Aplasia/Hypoplasia of the thymus (HP:0010515) | 1.75972358 |
| 131 | Cutaneous melanoma (HP:0012056) | 1.73867723 |
| 132 | Reduced subcutaneous adipose tissue (HP:0003758) | 1.73602960 |
| 133 | Bronchiectasis (HP:0002110) | 1.71807792 |
| 134 | Hepatitis (HP:0012115) | 1.71385070 |
| 135 | Increased serum ferritin (HP:0003281) | 1.71354708 |
| 136 | Large earlobe (HP:0009748) | 1.70386341 |
| 137 | Pancreatic cysts (HP:0001737) | 1.69838740 |
| 138 | Decreased muscle mass (HP:0003199) | 1.68369074 |
| 139 | Asplenia (HP:0001746) | 1.67793844 |
| 140 | Abnormality of the neuromuscular junction (HP:0003398) | 1.66876013 |
| 141 | Fatigable weakness (HP:0003473) | 1.66876013 |
| 142 | Increased mean platelet volume (HP:0011877) | 1.65843726 |
| 143 | Chest pain (HP:0100749) | 1.64855456 |
| 144 | Dislocated radial head (HP:0003083) | 1.63677368 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | TXK | 6.56504392 |
| 2 | MAP4K1 | 5.75669366 |
| 3 | ITK | 3.90181096 |
| 4 | BMPR2 | 3.57547492 |
| 5 | STK10 | 3.14424362 |
| 6 | ZAP70 | 3.00187189 |
| 7 | BCKDK | 2.86149125 |
| 8 | JAK3 | 2.83275026 |
| 9 | FGFR4 | 2.46931109 |
| 10 | CAMKK2 | 2.36382074 |
| 11 | GRK6 | 2.31341502 |
| 12 | TYK2 | 2.27702348 |
| 13 | MAP3K12 | 2.06992030 |
| 14 | TESK1 | 2.02897910 |
| 15 | NLK | 2.02873952 |
| 16 | IKBKE | 2.02868608 |
| 17 | MAP3K11 | 2.01927752 |
| 18 | TEC | 1.89143236 |
| 19 | EEF2K | 1.87140456 |
| 20 | LCK | 1.79159216 |
| 21 | CSK | 1.78903546 |
| 22 | MST4 | 1.73905520 |
| 23 | PINK1 | 1.71785883 |
| 24 | FGFR3 | 1.70576657 |
| 25 | JAK1 | 1.70066576 |
| 26 | LIMK1 | 1.68367068 |
| 27 | MAP3K13 | 1.58306921 |
| 28 | GRK7 | 1.57792263 |
| 29 | SYK | 1.53793988 |
| 30 | CAMKK1 | 1.52132556 |
| 31 | DMPK | 1.42215426 |
| 32 | BTK | 1.40834588 |
| 33 | LRRK2 | 1.39969446 |
| 34 | ZAK | 1.39531652 |
| 35 | BUB1 | 1.38030732 |
| 36 | MAP3K14 | 1.33724186 |
| 37 | IKBKB | 1.32251614 |
| 38 | HCK | 1.31069362 |
| 39 | MAP3K10 | 1.29541512 |
| 40 | TAOK3 | 1.24499036 |
| 41 | PRKCQ | 1.21001254 |
| 42 | PRKCH | 1.14128448 |
| 43 | SCYL2 | 1.14084457 |
| 44 | TBK1 | 1.08895555 |
| 45 | MAP2K6 | 1.03200611 |
| 46 | PKN2 | 1.02772204 |
| 47 | EPHB1 | 1.01961631 |
| 48 | MARK2 | 0.98881702 |
| 49 | CLK1 | 0.96933868 |
| 50 | GRK1 | 0.93892324 |
| 51 | BLK | 0.91850695 |
| 52 | VRK2 | 0.90908755 |
| 53 | MARK3 | 0.89756078 |
| 54 | MAP3K7 | 0.88661597 |
| 55 | PIM1 | 0.87526334 |
| 56 | PIK3CG | 0.87474582 |
| 57 | TAOK2 | 0.87038461 |
| 58 | TAOK1 | 0.86487394 |
| 59 | IRAK4 | 0.84307821 |
| 60 | FLT3 | 0.82311788 |
| 61 | WNK4 | 0.81853960 |
| 62 | RIPK4 | 0.81001184 |
| 63 | SIK2 | 0.80515915 |
| 64 | VRK1 | 0.80189573 |
| 65 | FES | 0.79997068 |
| 66 | PDGFRB | 0.79120541 |
| 67 | TRIB3 | 0.75823678 |
| 68 | NME2 | 0.75775591 |
| 69 | KIT | 0.75036440 |
| 70 | MYLK | 0.73586721 |
| 71 | MAPKAPK3 | 0.73067468 |
| 72 | STK4 | 0.72468323 |
| 73 | TLK1 | 0.72448516 |
| 74 | CDK4 | 0.72446614 |
| 75 | TGFBR2 | 0.70036402 |
| 76 | JAK2 | 0.68203721 |
| 77 | FGFR1 | 0.66278657 |
| 78 | EPHA3 | 0.66244217 |
| 79 | HIPK2 | 0.65405958 |
| 80 | LYN | 0.63297782 |
| 81 | ALK | 0.62400729 |
| 82 | PTK6 | 0.60298025 |
| 83 | PRKD2 | 0.58444975 |
| 84 | TIE1 | 0.57917913 |
| 85 | CDK9 | 0.57433980 |
| 86 | NUAK1 | 0.56958422 |
| 87 | PASK | 0.56948112 |
| 88 | CSF1R | 0.55893143 |
| 89 | TYRO3 | 0.55869038 |
| 90 | MELK | 0.55183268 |
| 91 | DAPK1 | 0.54264034 |
| 92 | IRAK1 | 0.53994056 |
| 93 | CDK19 | 0.53927176 |
| 94 | RPS6KA4 | 0.53294892 |
| 95 | PDK1 | 0.52513341 |
| 96 | MAPK7 | 0.51550040 |
| 97 | MAP4K2 | 0.51103084 |
| 98 | NME1 | 0.50731989 |
| 99 | FYN | 0.48910546 |
| 100 | MAP3K3 | 0.47957021 |
| 101 | TGFBR1 | 0.46262021 |
| 102 | CDK6 | 0.45702786 |
| 103 | INSR | 0.45339036 |
| 104 | CHUK | 0.44664427 |
| 105 | IGF1R | 0.44261565 |
| 106 | GSK3A | 0.42410950 |
| 107 | SRPK1 | 0.41883487 |
| 108 | KDR | 0.41598087 |
| 109 | TESK2 | 0.40639103 |
| 110 | MAPK3 | 0.39165098 |
| 111 | RPS6KB2 | 0.37827230 |
| 112 | MAPK12 | 0.37745963 |
| 113 | CDC7 | 0.36661622 |
| 114 | MAPK9 | 0.36247704 |
| 115 | ADRBK1 | 0.35399969 |
| 116 | CAMK1 | 0.35363356 |
| 117 | ROCK1 | 0.35264181 |
| 118 | MAPK11 | 0.35097400 |
| 119 | MAPK15 | 0.33213469 |
| 120 | MAP3K5 | 0.28736711 |
| 121 | MAP3K8 | 0.27190949 |
| 122 | CDK12 | 0.26803911 |
| 123 | BRSK2 | 0.26639082 |
| 124 | OBSCN | 0.26298352 |
| 125 | MAPK4 | 0.26272480 |
| 126 | TRPM7 | 0.26213964 |
| 127 | RET | 0.25901635 |
| 128 | SGK3 | 0.25178510 |
| 129 | ADRBK2 | 0.24182310 |
| 130 | INSRR | 0.23854014 |
| 131 | CAMK2A | 0.23638934 |
| 132 | SIK3 | 0.23468312 |
| 133 | RAF1 | 0.23035594 |
| 134 | PRKCA | 0.23017756 |
| 135 | FRK | 0.22910284 |
| 136 | ROCK2 | 0.22897720 |
| 137 | FGFR2 | 0.22124073 |
| 138 | MAPKAPK2 | 0.21619664 |
| 139 | IRAK2 | 0.21141935 |
| 140 | TNK2 | 0.20977348 |
| 141 | ILK | 0.20052602 |
| 142 | GRK5 | 0.19840927 |
| 143 | PRKACA | 0.18409536 |
| 144 | PAK4 | 0.18280907 |
| 145 | PIK3CA | 0.18258867 |
| 146 | AURKA | 0.17239547 |
| 147 | RPS6KA5 | 0.17191961 |
| 148 | MAPK8 | 0.16979811 |
| 149 | MATK | 0.16932856 |
| 150 | PRKD1 | 0.16148996 |
| 151 | EGFR | 0.15562071 |
| 152 | MAP3K1 | 0.14886154 |
| 153 | ABL1 | 0.12581050 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Primary immunodeficiency_Homo sapiens_hsa05340 | 5.60958493 |
| 2 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 4.73573634 |
| 3 | Graft-versus-host disease_Homo sapiens_hsa05332 | 3.48781170 |
| 4 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 3.37163676 |
| 5 | Measles_Homo sapiens_hsa05162 | 2.85660911 |
| 6 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 2.80899686 |
| 7 | Proteasome_Homo sapiens_hsa03050 | 2.72948170 |
| 8 | Antigen processing and presentation_Homo sapiens_hsa04612 | 2.66271785 |
| 9 | Allograft rejection_Homo sapiens_hsa05330 | 2.57355272 |
| 10 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 2.48963906 |
| 11 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 2.45493089 |
| 12 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 2.38608917 |
| 13 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 2.03366455 |
| 14 | Osteoclast differentiation_Homo sapiens_hsa04380 | 1.85195927 |
| 15 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 1.77023821 |
| 16 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 1.65150225 |
| 17 | Leishmaniasis_Homo sapiens_hsa05140 | 1.64733441 |
| 18 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 1.60887725 |
| 19 | Viral myocarditis_Homo sapiens_hsa05416 | 1.58706588 |
| 20 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 1.58014251 |
| 21 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 1.55654092 |
| 22 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 1.55176647 |
| 23 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 1.51891242 |
| 24 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 1.50000739 |
| 25 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.47536675 |
| 26 | Herpes simplex infection_Homo sapiens_hsa05168 | 1.45263101 |
| 27 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 1.38139835 |
| 28 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 1.37021523 |
| 29 | Pancreatic cancer_Homo sapiens_hsa05212 | 1.35659997 |
| 30 | Parkinsons disease_Homo sapiens_hsa05012 | 1.34511773 |
| 31 | Phototransduction_Homo sapiens_hsa04744 | 1.22201374 |
| 32 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 1.21758550 |
| 33 | TNF signaling pathway_Homo sapiens_hsa04668 | 1.20609463 |
| 34 | Toxoplasmosis_Homo sapiens_hsa05145 | 1.19883815 |
| 35 | Apoptosis_Homo sapiens_hsa04210 | 1.19067714 |
| 36 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 1.18943356 |
| 37 | Hepatitis B_Homo sapiens_hsa05161 | 1.17259767 |
| 38 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 1.13997288 |
| 39 | HTLV-I infection_Homo sapiens_hsa05166 | 1.13121545 |
| 40 | RNA polymerase_Homo sapiens_hsa03020 | 1.12595840 |
| 41 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 1.11525969 |
| 42 | Colorectal cancer_Homo sapiens_hsa05210 | 1.09790592 |
| 43 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 1.08298067 |
| 44 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 1.07509590 |
| 45 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 1.07454242 |
| 46 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.06523135 |
| 47 | Ribosome_Homo sapiens_hsa03010 | 1.02871731 |
| 48 | Asthma_Homo sapiens_hsa05310 | 1.00793132 |
| 49 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.00164402 |
| 50 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.99215259 |
| 51 | Platelet activation_Homo sapiens_hsa04611 | 0.96743961 |
| 52 | Influenza A_Homo sapiens_hsa05164 | 0.95927795 |
| 53 | Alzheimers disease_Homo sapiens_hsa05010 | 0.94928807 |
| 54 | Shigellosis_Homo sapiens_hsa05131 | 0.93821676 |
| 55 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.91126717 |
| 56 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.90352163 |
| 57 | Thyroid cancer_Homo sapiens_hsa05216 | 0.85415521 |
| 58 | Prion diseases_Homo sapiens_hsa05020 | 0.85386890 |
| 59 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.84128278 |
| 60 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.81063968 |
| 61 | Hepatitis C_Homo sapiens_hsa05160 | 0.79411378 |
| 62 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.72320828 |
| 63 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.67030643 |
| 64 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.66180023 |
| 65 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.64873409 |
| 66 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.64698851 |
| 67 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.63299596 |
| 68 | Spliceosome_Homo sapiens_hsa03040 | 0.62498324 |
| 69 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.61585300 |
| 70 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.61354859 |
| 71 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.60872951 |
| 72 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.58719507 |
| 73 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.58447689 |
| 74 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.57705485 |
| 75 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.57495249 |
| 76 | Huntingtons disease_Homo sapiens_hsa05016 | 0.57435732 |
| 77 | Salmonella infection_Homo sapiens_hsa05132 | 0.54558287 |
| 78 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.54358464 |
| 79 | Tuberculosis_Homo sapiens_hsa05152 | 0.53346418 |
| 80 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.53282906 |
| 81 | Endometrial cancer_Homo sapiens_hsa05213 | 0.50874333 |
| 82 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.49786978 |
| 83 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.49442445 |
| 84 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.49331488 |
| 85 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.49261959 |
| 86 | Legionellosis_Homo sapiens_hsa05134 | 0.49129530 |
| 87 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.47142978 |
| 88 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.46518613 |
| 89 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 0.45574231 |
| 90 | Malaria_Homo sapiens_hsa05144 | 0.45206725 |
| 91 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.44203620 |
| 92 | DNA replication_Homo sapiens_hsa03030 | 0.43157400 |
| 93 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.41069619 |
| 94 | Prostate cancer_Homo sapiens_hsa05215 | 0.41018090 |
| 95 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.40352302 |
| 96 | Endocytosis_Homo sapiens_hsa04144 | 0.38027333 |
| 97 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 0.37960669 |
| 98 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.37846114 |
| 99 | Mismatch repair_Homo sapiens_hsa03430 | 0.37163365 |
| 100 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.36593095 |
| 101 | Insulin resistance_Homo sapiens_hsa04931 | 0.35195662 |
| 102 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.34768658 |
| 103 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.33348798 |
| 104 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.32700816 |
| 105 | Pertussis_Homo sapiens_hsa05133 | 0.30930057 |
| 106 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.30734610 |
| 107 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.30640398 |
| 108 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.30600880 |
| 109 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.29812567 |
| 110 | RNA degradation_Homo sapiens_hsa03018 | 0.27176409 |
| 111 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.27073083 |
| 112 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.26789286 |
| 113 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.26208505 |
| 114 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.25621170 |
| 115 | Base excision repair_Homo sapiens_hsa03410 | 0.24981318 |
| 116 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.24943141 |
| 117 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.23908538 |
| 118 | Protein export_Homo sapiens_hsa03060 | 0.23701594 |
| 119 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 0.22308808 |
| 120 | Alcoholism_Homo sapiens_hsa05034 | 0.20376482 |
| 121 | Pathways in cancer_Homo sapiens_hsa05200 | 0.20193364 |
| 122 | Homologous recombination_Homo sapiens_hsa03440 | 0.19955448 |
| 123 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.19578045 |
| 124 | Olfactory transduction_Homo sapiens_hsa04740 | 0.19511178 |
| 125 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 0.19377817 |
| 126 | One carbon pool by folate_Homo sapiens_hsa00670 | 0.19044239 |
| 127 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.18583686 |
| 128 | Purine metabolism_Homo sapiens_hsa00230 | 0.17291063 |
| 129 | Lysine degradation_Homo sapiens_hsa00310 | 0.16926710 |
| 130 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.16890277 |
| 131 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.15691800 |
| 132 | Phagosome_Homo sapiens_hsa04145 | 0.15260914 |
| 133 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.14197994 |
| 134 | Retinol metabolism_Homo sapiens_hsa00830 | 0.13382115 |
| 135 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.13233619 |
| 136 | Morphine addiction_Homo sapiens_hsa05032 | 0.10299001 |
| 137 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.09525863 |
| 138 | Peroxisome_Homo sapiens_hsa04146 | 0.09116406 |
| 139 | ABC transporters_Homo sapiens_hsa02010 | 0.08479249 |
| 140 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.04656148 |
| 141 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.03924963 |
| 142 | Amphetamine addiction_Homo sapiens_hsa05031 | 0.02083069 |

