

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | negative T cell selection (GO:0043383) | 8.72656159 |
| 2 | positive regulation of gamma-delta T cell activation (GO:0046645) | 8.64992741 |
| 3 | negative regulation of leukocyte mediated cytotoxicity (GO:0001911) | 8.53641498 |
| 4 | negative regulation of cell killing (GO:0031342) | 8.53641498 |
| 5 | negative thymic T cell selection (GO:0045060) | 8.05726253 |
| 6 | NIK/NF-kappaB signaling (GO:0038061) | 7.33881792 |
| 7 | positive regulation of antigen receptor-mediated signaling pathway (GO:0050857) | 7.17685351 |
| 8 | regulation of gamma-delta T cell differentiation (GO:0045586) | 7.12014453 |
| 9 | positive T cell selection (GO:0043368) | 7.07264040 |
| 10 | regulation of isotype switching to IgG isotypes (GO:0048302) | 7.07072328 |
| 11 | positive thymic T cell selection (GO:0045059) | 6.83433582 |
| 12 | interferon-gamma production (GO:0032609) | 6.73743932 |
| 13 | thymic T cell selection (GO:0045061) | 6.69292956 |
| 14 | response to interleukin-15 (GO:0070672) | 6.55655959 |
| 15 | T cell selection (GO:0045058) | 6.45178709 |
| 16 | regulation of T cell tolerance induction (GO:0002664) | 6.39629173 |
| 17 | regulation of gamma-delta T cell activation (GO:0046643) | 6.38651695 |
| 18 | antigen processing and presentation of endogenous peptide antigen (GO:0002483) | 6.17911816 |
| 19 | antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885) | 6.17911816 |
| 20 | pyrimidine ribonucleoside catabolic process (GO:0046133) | 6.07144046 |
| 21 | cytidine metabolic process (GO:0046087) | 6.03584453 |
| 22 | cytidine catabolic process (GO:0006216) | 6.03584453 |
| 23 | cytidine deamination (GO:0009972) | 6.03584453 |
| 24 | positive regulation of interleukin-2 biosynthetic process (GO:0045086) | 6.01578269 |
| 25 | cellular response to interleukin-15 (GO:0071350) | 6.01198115 |
| 26 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G | 5.91889193 |
| 27 | T cell receptor signaling pathway (GO:0050852) | 5.74572153 |
| 28 | T cell migration (GO:0072678) | 5.47785507 |
| 29 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 5.37667331 |
| 30 | T cell costimulation (GO:0031295) | 5.31937608 |
| 31 | positive regulation of tolerance induction (GO:0002645) | 5.30219949 |
| 32 | antigen processing and presentation of endogenous antigen (GO:0019883) | 5.23684201 |
| 33 | lymphocyte costimulation (GO:0031294) | 5.22373802 |
| 34 | leukocyte aggregation (GO:0070486) | 5.20196914 |
| 35 | DNA deamination (GO:0045006) | 5.08916747 |
| 36 | activated T cell proliferation (GO:0050798) | 5.07151029 |
| 37 | regulation of alpha-beta T cell proliferation (GO:0046640) | 4.93370346 |
| 38 | Arp2/3 complex-mediated actin nucleation (GO:0034314) | 4.90765782 |
| 39 | negative regulation of T cell apoptotic process (GO:0070233) | 4.85228239 |
| 40 | positive regulation of B cell differentiation (GO:0045579) | 4.80015461 |
| 41 | antigen receptor-mediated signaling pathway (GO:0050851) | 4.77981200 |
| 42 | positive regulation of alpha-beta T cell proliferation (GO:0046641) | 4.77095681 |
| 43 | negative regulation of T cell mediated immunity (GO:0002710) | 4.73953200 |
| 44 | regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923) | 4.67747468 |
| 45 | regulation of tolerance induction (GO:0002643) | 4.63076093 |
| 46 | regulation of T cell receptor signaling pathway (GO:0050856) | 4.61585041 |
| 47 | regulation of antigen receptor-mediated signaling pathway (GO:0050854) | 4.52429786 |
| 48 | positive regulation of isotype switching (GO:0045830) | 4.48515752 |
| 49 | regulation of natural killer cell mediated cytotoxicity (GO:0042269) | 4.34796805 |
| 50 | regulation of natural killer cell mediated immunity (GO:0002715) | 4.34796805 |
| 51 | regulation of B cell receptor signaling pathway (GO:0050855) | 4.31182266 |
| 52 | positive regulation of B cell mediated immunity (GO:0002714) | 4.23734620 |
| 53 | positive regulation of immunoglobulin mediated immune response (GO:0002891) | 4.23734620 |
| 54 | positive regulation of interleukin-2 production (GO:0032743) | 4.18820327 |
| 55 | mast cell activation (GO:0045576) | 4.18408886 |
| 56 | regulation of interleukin-2 biosynthetic process (GO:0045076) | 4.17504776 |
| 57 | actin nucleation (GO:0045010) | 4.17474747 |
| 58 | positive regulation of humoral immune response (GO:0002922) | 4.08498732 |
| 59 | positive regulation of natural killer cell mediated immunity (GO:0002717) | 4.04924540 |
| 60 | positive regulation of natural killer cell mediated cytotoxicity (GO:0045954) | 4.04924540 |
| 61 | regulation of regulatory T cell differentiation (GO:0045589) | 4.03613309 |
| 62 | regulation of isotype switching (GO:0045191) | 4.02576112 |
| 63 | regulation of T cell apoptotic process (GO:0070232) | 3.96680964 |
| 64 | T cell differentiation (GO:0030217) | 3.88785995 |
| 65 | alpha-beta T cell activation (GO:0046631) | 3.88387587 |
| 66 | regulation of activation of Janus kinase activity (GO:0010533) | 3.87852981 |
| 67 | antigen processing and presentation via MHC class Ib (GO:0002475) | 3.86229597 |
| 68 | V(D)J recombination (GO:0033151) | 3.85317666 |
| 69 | regulation of immunoglobulin mediated immune response (GO:0002889) | 3.84553634 |
| 70 | positive regulation of DNA recombination (GO:0045911) | 3.82782889 |
| 71 | positive regulation of immunoglobulin production (GO:0002639) | 3.76500008 |
| 72 | alpha-beta T cell differentiation (GO:0046632) | 3.75480586 |
| 73 | regulation of leukocyte mediated cytotoxicity (GO:0001910) | 3.74725252 |
| 74 | regulation of B cell mediated immunity (GO:0002712) | 3.72899404 |
| 75 | negative regulation of lymphocyte mediated immunity (GO:0002707) | 3.69715472 |
| 76 | monocyte chemotaxis (GO:0002548) | 3.61514910 |
| 77 | positive regulation of leukocyte mediated cytotoxicity (GO:0001912) | 3.60153725 |
| 78 | regulation of response to interferon-gamma (GO:0060330) | 3.57349471 |
| 79 | T cell activation (GO:0042110) | 3.56393622 |
| 80 | positive regulation of T cell chemotaxis (GO:0010820) | 3.56343611 |
| 81 | regulation of T cell chemotaxis (GO:0010819) | 3.56343611 |
| 82 | regulation of immunoglobulin production (GO:0002637) | 3.53019373 |
| 83 | negative regulation of T cell receptor signaling pathway (GO:0050860) | 3.52690101 |
| 84 | T cell proliferation (GO:0042098) | 3.48942532 |
| 85 | regulation of interferon-gamma-mediated signaling pathway (GO:0060334) | 3.47947765 |
| 86 | leukocyte degranulation (GO:0043299) | 3.47817956 |
| 87 | negative regulation of viral genome replication (GO:0045071) | 3.46556582 |
| 88 | regulation of cell killing (GO:0031341) | 3.46551309 |
| 89 | cellular response to interleukin-4 (GO:0071353) | 3.43269460 |
| 90 | I-kappaB phosphorylation (GO:0007252) | 3.41952681 |
| 91 | natural killer cell activation (GO:0030101) | 3.41643478 |
| 92 | regulation of granulocyte differentiation (GO:0030852) | 3.41493957 |
| 93 | regulation of response to tumor cell (GO:0002834) | 3.41433351 |
| 94 | positive regulation of response to tumor cell (GO:0002836) | 3.41433351 |
| 95 | positive regulation of immune response to tumor cell (GO:0002839) | 3.41433351 |
| 96 | regulation of immune response to tumor cell (GO:0002837) | 3.41433351 |
| 97 | negative regulation of phagocytosis (GO:0050765) | 3.39772704 |
| 98 | lymphocyte migration (GO:0072676) | 3.39492756 |
| 99 | negative regulation of organelle assembly (GO:1902116) | 3.36717780 |
| 100 | mucosal-associated lymphoid tissue development (GO:0048537) | 3.35734112 |
| 101 | Peyers patch development (GO:0048541) | 3.35734112 |
| 102 | immune response-activating cell surface receptor signaling pathway (GO:0002429) | 3.34287044 |
| 103 | mast cell activation involved in immune response (GO:0002279) | 3.34019247 |
| 104 | mast cell degranulation (GO:0043303) | 3.34019247 |
| 105 | negative regulation of antigen receptor-mediated signaling pathway (GO:0050858) | 3.33846158 |
| 106 | positive regulation of cell killing (GO:0031343) | 3.31639986 |
| 107 | regulation of interleukin-12 biosynthetic process (GO:0045075) | 3.28758498 |
| 108 | T cell homeostasis (GO:0043029) | 3.27733290 |
| 109 | regulation of interleukin-4 production (GO:0032673) | 3.27512602 |
| 110 | heterotypic cell-cell adhesion (GO:0034113) | 3.27284815 |
| 111 | regulation of B cell differentiation (GO:0045577) | 3.25725651 |
| 112 | regulation of lymphocyte chemotaxis (GO:1901623) | 3.25452889 |
| 113 | pyrimidine nucleoside catabolic process (GO:0046135) | 3.25041898 |
| 114 | ribosomal small subunit assembly (GO:0000028) | 3.23049066 |
| 115 | negative regulation of lymphocyte apoptotic process (GO:0070229) | 3.22980742 |
| 116 | positive regulation of T cell mediated cytotoxicity (GO:0001916) | 3.22918490 |
| 117 | leukocyte cell-cell adhesion (GO:0007159) | 3.22410204 |
| 118 | positive regulation of calcium-mediated signaling (GO:0050850) | 3.20567753 |
| 119 | regulation of interleukin-2 production (GO:0032663) | 3.19940511 |
| 120 | positive regulation of T cell cytokine production (GO:0002726) | 3.19858698 |
| 121 | signal complex assembly (GO:0007172) | 3.19009517 |
| 122 | lymph node development (GO:0048535) | 3.18369915 |
| 123 | regulation of defense response to virus by virus (GO:0050690) | 3.17606294 |
| 124 | negative regulation of leukocyte mediated immunity (GO:0002704) | 3.17133649 |
| 125 | regulation of T cell migration (GO:2000404) | 3.16432508 |
| 126 | dendritic cell chemotaxis (GO:0002407) | 3.14272863 |
| 127 | phospholipase C-activating dopamine receptor signaling pathway (GO:0060158) | 3.14019204 |
| 128 | response to interleukin-4 (GO:0070670) | 3.12262481 |
| 129 | regulation of necroptotic process (GO:0060544) | 3.10763852 |
| 130 | positive regulation of T cell activation (GO:0050870) | 3.08987121 |
| 131 | positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523) | 3.05184975 |
| 132 | B cell receptor signaling pathway (GO:0050853) | 3.03491935 |
| 133 | positive regulation of lymphocyte mediated immunity (GO:0002708) | 3.02026741 |
| 134 | regulation of lymphocyte mediated immunity (GO:0002706) | 3.01845098 |
| 135 | regulation of T cell mediated cytotoxicity (GO:0001914) | 2.94694449 |
| 136 | positive regulation of interleukin-4 production (GO:0032753) | 2.92054740 |
| 137 | natural killer cell differentiation (GO:0001779) | 2.91442957 |
| 138 | positive regulation of granulocyte differentiation (GO:0030854) | 2.85691102 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 8.23879942 |
| 2 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 6.40937883 |
| 3 | E2F7_22180533_ChIP-Seq_HELA_Human | 4.64697169 |
| 4 | RUNX_20019798_ChIP-Seq_JUKART_Human | 4.24950500 |
| 5 | STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 3.83937458 |
| 6 | FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse | 3.73122643 |
| 7 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 3.62702338 |
| 8 | MYC_22102868_ChIP-Seq_BL_Human | 3.54071369 |
| 9 | MYB_26560356_Chip-Seq_TH2_Human | 3.46261990 |
| 10 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 3.26642912 |
| 11 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 3.18248839 |
| 12 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 3.17286233 |
| 13 | MAF_26560356_Chip-Seq_TH1_Human | 3.05864196 |
| 14 | MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 3.04633272 |
| 15 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 3.02932576 |
| 16 | UTX_26944678_Chip-Seq_JUKART_Human | 2.82138714 |
| 17 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 2.78887974 |
| 18 | MYB_26560356_Chip-Seq_TH1_Human | 2.71486291 |
| 19 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 2.69060415 |
| 20 | GATA3_27048872_Chip-Seq_THYMUS_Human | 2.36317207 |
| 21 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.31363402 |
| 22 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 2.30507458 |
| 23 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 2.29843221 |
| 24 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 2.24369960 |
| 25 | KDM2B_26808549_Chip-Seq_HPB-ALL_Human | 2.20181416 |
| 26 | VDR_21846776_ChIP-Seq_THP-1_Human | 2.17173262 |
| 27 | MAF_26560356_Chip-Seq_TH2_Human | 2.10547331 |
| 28 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 2.02643429 |
| 29 | RUNX1_22412390_ChIP-Seq_EML_Mouse | 1.95979718 |
| 30 | TCF7_22412390_ChIP-Seq_EML_Mouse | 1.91656054 |
| 31 | SCL_19346495_ChIP-Seq_HPC-7_Human | 1.83554916 |
| 32 | SPI1_23547873_ChIP-Seq_NB4_Human | 1.80934924 |
| 33 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 1.79614587 |
| 34 | E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 1.79478220 |
| 35 | SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse | 1.78522145 |
| 36 | NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse | 1.78325112 |
| 37 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.77636687 |
| 38 | RUNX1_17652178_ChIP-ChIP_JURKAT_Human | 1.77283775 |
| 39 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 1.74774235 |
| 40 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 1.74130139 |
| 41 | IRF8_27001747_Chip-Seq_BMDM_Mouse | 1.73043047 |
| 42 | KDM2B_26808549_Chip-Seq_DND41_Human | 1.73033714 |
| 43 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 1.71586694 |
| 44 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 1.67443653 |
| 45 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.59189853 |
| 46 | VDR_24763502_ChIP-Seq_THP-1_Human | 1.57535744 |
| 47 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.55750224 |
| 48 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 1.55452494 |
| 49 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 1.54275480 |
| 50 | SPI1_23127762_ChIP-Seq_K562_Human | 1.52720958 |
| 51 | CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human | 1.50114763 |
| 52 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.47947520 |
| 53 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.44934120 |
| 54 | BRD4_27068464_Chip-Seq_AML-cells_Mouse | 1.44013029 |
| 55 | BCL6_27268052_Chip-Seq_Bcells_Human | 1.42701552 |
| 56 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.35530778 |
| 57 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.35472028 |
| 58 | GATA3_26560356_Chip-Seq_TH2_Human | 1.30776139 |
| 59 | MEIS1_20887958_ChIP-Seq_HPC-7_Mouse | 1.28614033 |
| 60 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.24825316 |
| 61 | KDM2B_26808549_Chip-Seq_JURKAT_Human | 1.24291757 |
| 62 | PU_27001747_Chip-Seq_BMDM_Mouse | 1.20479706 |
| 63 | GATA2_22383799_ChIP-Seq_G1ME_Mouse | 1.20177548 |
| 64 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.18697207 |
| 65 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 1.17995778 |
| 66 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 1.17943775 |
| 67 | PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.16179773 |
| 68 | BCOR_27268052_Chip-Seq_Bcells_Human | 1.15994616 |
| 69 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.14707851 |
| 70 | TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse | 1.13473523 |
| 71 | VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human | 1.10195665 |
| 72 | VDR_23849224_ChIP-Seq_CD4+_Human | 1.05131905 |
| 73 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 1.04932335 |
| 74 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 1.04518888 |
| 75 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 1.03579930 |
| 76 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.03005198 |
| 77 | PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse | 0.98599568 |
| 78 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 0.97965925 |
| 79 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 0.97747075 |
| 80 | P300_27268052_Chip-Seq_Bcells_Human | 0.95725171 |
| 81 | LMO2_20887958_ChIP-Seq_HPC-7_Mouse | 0.94624007 |
| 82 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 0.93884407 |
| 83 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 0.93630075 |
| 84 | RBPJ_21746931_ChIP-Seq_IB4-LCL_Human | 0.90933598 |
| 85 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 0.89780515 |
| 86 | CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse | 0.89728865 |
| 87 | ELK1_19687146_ChIP-ChIP_HELA_Human | 0.89441378 |
| 88 | PU.1_20513432_ChIP-Seq_Bcells_Mouse | 0.88960121 |
| 89 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 0.87538561 |
| 90 | CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 0.86556139 |
| 91 | GATA1_22383799_ChIP-Seq_G1ME_Mouse | 0.85944409 |
| 92 | CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse | 0.83857548 |
| 93 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 0.83589882 |
| 94 | TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.82697336 |
| 95 | SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 0.82458733 |
| 96 | RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.81255313 |
| 97 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 0.81153627 |
| 98 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 0.79620240 |
| 99 | SPI1_20517297_ChIP-Seq_HL60_Human | 0.79532236 |
| 100 | PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse | 0.79005530 |
| 101 | SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human | 0.78126254 |
| 102 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.75138032 |
| 103 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 0.74510827 |
| 104 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 0.74483043 |
| 105 | CTCF_26484167_Chip-Seq_Bcells_Mouse | 0.73717736 |
| 106 | GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.73528284 |
| 107 | NCOR1_26117541_ChIP-Seq_K562_Human | 0.73140683 |
| 108 | GATA2_20887958_ChIP-Seq_HPC-7_Mouse | 0.69527026 |
| 109 | CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse | 0.69507894 |
| 110 | PHF8_20622854_ChIP-Seq_HELA_Human | 0.69383319 |
| 111 | E2F1_20622854_ChIP-Seq_HELA_Human | 0.68818459 |
| 112 | XRN2_22483619_ChIP-Seq_HELA_Human | 0.68300775 |
| 113 | ETS1_21867929_ChIP-Seq_TH2_Mouse | 0.68225210 |
| 114 | CTCF_21964334_ChIP-Seq_BJAB-B_Human | 0.68212783 |
| 115 | GATA3_26560356_Chip-Seq_TH1_Human | 0.68138903 |
| 116 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.67974838 |
| 117 | GATA2_19941826_ChIP-Seq_K562_Human | 0.67653711 |
| 118 | SMRT_27268052_Chip-Seq_Bcells_Human | 0.66854187 |
| 119 | GATA1_19941826_ChIP-Seq_K562_Human | 0.66780993 |
| 120 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 0.65787197 |
| 121 | VDR_24787735_ChIP-Seq_THP-1_Human | 0.64287941 |
| 122 | KDM5A_27292631_Chip-Seq_BREAST_Human | 0.63476254 |
| 123 | TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.63215492 |
| 124 | PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse | 0.60610462 |
| 125 | RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.60479972 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003763_abnormal_thymus_physiology | 5.88849456 |
| 2 | MP0005671_abnormal_response_to | 4.90208920 |
| 3 | MP0000685_abnormal_immune_system | 3.70712698 |
| 4 | MP0001835_abnormal_antigen_presentation | 3.51481843 |
| 5 | MP0001800_abnormal_humoral_immune | 3.43878656 |
| 6 | MP0000703_abnormal_thymus_morphology | 3.16694959 |
| 7 | MP0009333_abnormal_splenocyte_physiolog | 3.15015397 |
| 8 | MP0002398_abnormal_bone_marrow | 3.14504971 |
| 9 | MP0002420_abnormal_adaptive_immunity | 3.03642356 |
| 10 | MP0001819_abnormal_immune_cell | 2.98887984 |
| 11 | MP0002723_abnormal_immune_serum | 2.87936283 |
| 12 | MP0005000_abnormal_immune_tolerance | 2.83529386 |
| 13 | MP0005387_immune_system_phenotype | 2.72879832 |
| 14 | MP0001790_abnormal_immune_system | 2.72879832 |
| 15 | MP0002166_altered_tumor_susceptibility | 2.69963079 |
| 16 | MP0000716_abnormal_immune_system | 2.67484302 |
| 17 | MP0002452_abnormal_antigen_presenting | 2.66122913 |
| 18 | MP0002396_abnormal_hematopoietic_system | 2.62788060 |
| 19 | MP0002722_abnormal_immune_system | 2.58037667 |
| 20 | MP0002405_respiratory_system_inflammati | 2.51012238 |
| 21 | MP0003300_gastrointestinal_ulcer | 2.42777564 |
| 22 | MP0005025_abnormal_response_to | 2.39827818 |
| 23 | MP0000689_abnormal_spleen_morphology | 2.38872261 |
| 24 | MP0003436_decreased_susceptibility_to | 2.28145492 |
| 25 | MP0002006_tumorigenesis | 2.21591324 |
| 26 | MP0009785_altered_susceptibility_to | 2.20936810 |
| 27 | MP0002429_abnormal_blood_cell | 2.19907941 |
| 28 | MP0010155_abnormal_intestine_physiology | 2.19205174 |
| 29 | MP0003724_increased_susceptibility_to | 2.14018366 |
| 30 | MP0004947_skin_inflammation | 2.12861771 |
| 31 | MP0006082_CNS_inflammation | 2.11090247 |
| 32 | MP0001873_stomach_inflammation | 2.03940495 |
| 33 | MP0002148_abnormal_hypersensitivity_rea | 2.03130634 |
| 34 | MP0003866_abnormal_defecation | 2.02458448 |
| 35 | MP0002277_abnormal_respiratory_mucosa | 1.89043955 |
| 36 | MP0002419_abnormal_innate_immunity | 1.85693935 |
| 37 | MP0005464_abnormal_platelet_physiology | 1.85154269 |
| 38 | MP0004381_abnormal_hair_follicle | 1.69726323 |
| 39 | MP0001845_abnormal_inflammatory_respons | 1.68109636 |
| 40 | MP0000858_altered_metastatic_potential | 1.66125277 |
| 41 | MP0004808_abnormal_hematopoietic_stem | 1.63657962 |
| 42 | MP0002933_joint_inflammation | 1.61087782 |
| 43 | MP0000465_gastrointestinal_hemorrhage | 1.46683708 |
| 44 | MP0003448_altered_tumor_morphology | 1.34193875 |
| 45 | MP0001853_heart_inflammation | 1.32124717 |
| 46 | MP0003303_peritoneal_inflammation | 1.31552579 |
| 47 | MP0002909_abnormal_adrenal_gland | 1.21196006 |
| 48 | MP0005075_abnormal_melanosome_morpholog | 1.15856295 |
| 49 | MP0003786_premature_aging | 1.14064822 |
| 50 | MP0002019_abnormal_tumor_incidence | 1.13689211 |
| 51 | MP0008961_abnormal_basal_metabolism | 1.13078165 |
| 52 | MP0002009_preneoplasia | 1.12407395 |
| 53 | MP0003646_muscle_fatigue | 1.08867438 |
| 54 | MP0000490_abnormal_crypts_of | 1.08554169 |
| 55 | MP0002132_abnormal_respiratory_system | 1.07491695 |
| 56 | MP0010352_gastrointestinal_tract_polyps | 1.07299983 |
| 57 | MP0001545_abnormal_hematopoietic_system | 0.99347033 |
| 58 | MP0005397_hematopoietic_system_phenotyp | 0.99347033 |
| 59 | MP0008469_abnormal_protein_level | 0.98000310 |
| 60 | MP0001533_abnormal_skeleton_physiology | 0.97340894 |
| 61 | MP0001919_abnormal_reproductive_system | 0.97211924 |
| 62 | MP0001501_abnormal_sleep_pattern | 0.96890193 |
| 63 | MP0008057_abnormal_DNA_replication | 0.91649134 |
| 64 | MP0005023_abnormal_wound_healing | 0.90577132 |
| 65 | MP0003045_fibrosis | 0.90030948 |
| 66 | MP0001851_eye_inflammation | 0.89685395 |
| 67 | MP0000015_abnormal_ear_pigmentation | 0.88216238 |
| 68 | MP0010094_abnormal_chromosome_stability | 0.87448101 |
| 69 | MP0003077_abnormal_cell_cycle | 0.86607012 |
| 70 | MP0004510_myositis | 0.85426214 |
| 71 | MP0005076_abnormal_cell_differentiation | 0.83756381 |
| 72 | MP0005310_abnormal_salivary_gland | 0.83217442 |
| 73 | MP0005377_hearing/vestibular/ear_phenot | 0.82062345 |
| 74 | MP0003878_abnormal_ear_physiology | 0.82062345 |
| 75 | MP0001663_abnormal_digestive_system | 0.77525631 |
| 76 | MP0002095_abnormal_skin_pigmentation | 0.77129315 |
| 77 | MP0001542_abnormal_bone_strength | 0.75122602 |
| 78 | MP0006054_spinal_hemorrhage | 0.74381433 |
| 79 | MP0002693_abnormal_pancreas_physiology | 0.73552875 |
| 80 | MP0004957_abnormal_blastocyst_morpholog | 0.72451454 |
| 81 | MP0004185_abnormal_adipocyte_glucose | 0.71841165 |
| 82 | MP0009765_abnormal_xenobiotic_induced | 0.71451317 |
| 83 | MP0002998_abnormal_bone_remodeling | 0.69253269 |
| 84 | MP0005409_darkened_coat_color | 0.68969341 |
| 85 | MP0000604_amyloidosis | 0.66539269 |
| 86 | MP0001986_abnormal_taste_sensitivity | 0.65198248 |
| 87 | MP0009763_increased_sensitivity_to | 0.63416225 |
| 88 | MP0008260_abnormal_autophagy | 0.62068279 |
| 89 | MP0000609_abnormal_liver_physiology | 0.61795004 |
| 90 | MP0009278_abnormal_bone_marrow | 0.61641963 |
| 91 | MP0008995_early_reproductive_senescence | 0.58859713 |
| 92 | MP0001905_abnormal_dopamine_level | 0.57206634 |
| 93 | MP0008007_abnormal_cellular_replicative | 0.56102243 |
| 94 | MP0008004_abnormal_stomach_pH | 0.55871427 |
| 95 | MP0009643_abnormal_urine_homeostasis | 0.53630360 |
| 96 | MP0000477_abnormal_intestine_morphology | 0.53377181 |
| 97 | MP0005174_abnormal_tail_pigmentation | 0.53203336 |
| 98 | MP0003693_abnormal_embryo_hatching | 0.52784765 |
| 99 | MP0003137_abnormal_impulse_conducting | 0.52618045 |
| 100 | MP0008873_increased_physiological_sensi | 0.52051114 |
| 101 | MP0009764_decreased_sensitivity_to | 0.51974575 |
| 102 | MP0005390_skeleton_phenotype | 0.51599691 |
| 103 | MP0000569_abnormal_digit_pigmentation | 0.50796556 |
| 104 | MP0000350_abnormal_cell_proliferation | 0.49795705 |
| 105 | MP0002136_abnormal_kidney_physiology | 0.49462125 |
| 106 | MP0003111_abnormal_nucleus_morphology | 0.48337102 |
| 107 | MP0003795_abnormal_bone_structure | 0.47797855 |
| 108 | MP0003453_abnormal_keratinocyte_physiol | 0.47141656 |
| 109 | MP0005381_digestive/alimentary_phenotyp | 0.45337106 |
| 110 | MP0004883_abnormal_blood_vessel | 0.45107326 |
| 111 | MP0001243_abnormal_dermal_layer | 0.44078709 |
| 112 | MP0001881_abnormal_mammary_gland | 0.44008388 |
| 113 | MP0005266_abnormal_metabolism | 0.43755581 |
| 114 | MP0008877_abnormal_DNA_methylation | 0.43632132 |
| 115 | MP0000249_abnormal_blood_vessel | 0.42771346 |
| 116 | MP0005645_abnormal_hypothalamus_physiol | 0.42400112 |
| 117 | MP0005389_reproductive_system_phenotype | 0.42101020 |
| 118 | MP0005410_abnormal_fertilization | 0.42019214 |
| 119 | MP0000920_abnormal_myelination | 0.41388560 |
| 120 | MP0003091_abnormal_cell_migration | 0.41315539 |
| 121 | MP0004130_abnormal_muscle_cell | 0.41062010 |
| 122 | MP0003806_abnormal_nucleotide_metabolis | 0.40971007 |
| 123 | MP0002083_premature_death | 0.39938814 |
| 124 | MP0000313_abnormal_cell_death | 0.39048054 |
| 125 | MP0002102_abnormal_ear_morphology | 0.38799172 |
| 126 | MP0000733_abnormal_muscle_development | 0.38661312 |
| 127 | MP0002822_catalepsy | 0.38151570 |
| 128 | MP0001730_embryonic_growth_arrest | 0.37534607 |
| 129 | MP0002086_abnormal_extraembryonic_tissu | 0.37412911 |
| 130 | MP0008770_decreased_survivor_rate | 0.37137429 |
| 131 | MP0001216_abnormal_epidermal_layer | 0.37005833 |
| 132 | MP0002970_abnormal_white_adipose | 0.36725791 |
| 133 | MP0008058_abnormal_DNA_repair | 0.36626382 |
| 134 | MP0000367_abnormal_coat/_hair | 0.36330588 |
| 135 | MP0001958_emphysema | 0.35531610 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | T lymphocytopenia (HP:0005403) | 9.34862856 |
| 2 | Abnormality of T cell number (HP:0011839) | 8.92469384 |
| 3 | Aplastic anemia (HP:0001915) | 6.59160947 |
| 4 | Abnormality of T cells (HP:0002843) | 5.80118371 |
| 5 | Elevated erythrocyte sedimentation rate (HP:0003565) | 5.68535183 |
| 6 | Combined immunodeficiency (HP:0005387) | 5.53721252 |
| 7 | Severe combined immunodeficiency (HP:0004430) | 5.53064305 |
| 8 | Recurrent viral infections (HP:0004429) | 5.06419437 |
| 9 | Panhypogammaglobulinemia (HP:0003139) | 4.62096408 |
| 10 | Abnormality of macrophages (HP:0004311) | 4.58205195 |
| 11 | Eosinophilia (HP:0001880) | 4.46224467 |
| 12 | Nasal polyposis (HP:0100582) | 4.40654329 |
| 13 | Abnormality of eosinophils (HP:0001879) | 4.38419657 |
| 14 | Recurrent fungal infections (HP:0002841) | 4.37778967 |
| 15 | Recurrent bronchitis (HP:0002837) | 4.33359785 |
| 16 | IgG deficiency (HP:0004315) | 4.31284784 |
| 17 | Stomatitis (HP:0010280) | 4.14488854 |
| 18 | Autoimmune hemolytic anemia (HP:0001890) | 4.11383459 |
| 19 | Chronic otitis media (HP:0000389) | 4.09713301 |
| 20 | Thyroiditis (HP:0100646) | 3.97790907 |
| 21 | Myositis (HP:0100614) | 3.82524248 |
| 22 | Pustule (HP:0200039) | 3.80829463 |
| 23 | IgM deficiency (HP:0002850) | 3.80159068 |
| 24 | Granulocytopenia (HP:0001913) | 3.76949917 |
| 25 | Leukocytosis (HP:0001974) | 3.71362733 |
| 26 | B lymphocytopenia (HP:0010976) | 3.70268040 |
| 27 | Abnormality of B cell number (HP:0010975) | 3.70268040 |
| 28 | Abnormal delayed hypersensitivity skin test (HP:0002963) | 3.70182924 |
| 29 | Anomalous pulmonary venous return (HP:0010772) | 3.69063843 |
| 30 | Abnormality of the nasal mucosa (HP:0000433) | 3.62571774 |
| 31 | Joint swelling (HP:0001386) | 3.62005267 |
| 32 | Abnormality of the fingertips (HP:0001211) | 3.38076128 |
| 33 | Chronic mucocutaneous candidiasis (HP:0002728) | 3.36154239 |
| 34 | Recurrent cutaneous fungal infections (HP:0011370) | 3.36154239 |
| 35 | Hypoproteinemia (HP:0003075) | 3.26171657 |
| 36 | Chronic diarrhea (HP:0002028) | 3.23832046 |
| 37 | Hypoplasia of the thymus (HP:0000778) | 3.23691589 |
| 38 | Abnormality of the pulmonary veins (HP:0011718) | 3.23053154 |
| 39 | Lymphopenia (HP:0001888) | 3.14472590 |
| 40 | Cutaneous melanoma (HP:0012056) | 3.13644785 |
| 41 | Abnormality of cells of the lymphoid lineage (HP:0012140) | 3.02810432 |
| 42 | Eczematoid dermatitis (HP:0000976) | 2.98669202 |
| 43 | Meningitis (HP:0001287) | 2.91071248 |
| 44 | Autoimmune thrombocytopenia (HP:0001973) | 2.89886685 |
| 45 | Abnormality of T cell physiology (HP:0011840) | 2.89304500 |
| 46 | Papilloma (HP:0012740) | 2.87217573 |
| 47 | Verrucae (HP:0200043) | 2.87217573 |
| 48 | Thrombocytosis (HP:0001894) | 2.86916800 |
| 49 | Encephalitis (HP:0002383) | 2.79529775 |
| 50 | Basal cell carcinoma (HP:0002671) | 2.76893207 |
| 51 | Spontaneous hematomas (HP:0007420) | 2.74077300 |
| 52 | Agammaglobulinemia (HP:0004432) | 2.68383472 |
| 53 | Rib fusion (HP:0000902) | 2.67332124 |
| 54 | Increased IgM level (HP:0003496) | 2.67320037 |
| 55 | Acute hepatic failure (HP:0006554) | 2.65811778 |
| 56 | Lymphoma (HP:0002665) | 2.60075503 |
| 57 | Recurrent abscess formation (HP:0002722) | 2.53958844 |
| 58 | Inflammation of the large intestine (HP:0002037) | 2.53911189 |
| 59 | Volvulus (HP:0002580) | 2.53731548 |
| 60 | Gastrointestinal inflammation (HP:0004386) | 2.47642900 |
| 61 | Bronchitis (HP:0012387) | 2.46235589 |
| 62 | Gangrene (HP:0100758) | 2.43464803 |
| 63 | Mediastinal lymphadenopathy (HP:0100721) | 2.40492813 |
| 64 | Slow saccadic eye movements (HP:0000514) | 2.37795728 |
| 65 | Pancytopenia (HP:0001876) | 2.37131612 |
| 66 | Recurrent sinusitis (HP:0011108) | 2.36327997 |
| 67 | Amyotrophic lateral sclerosis (HP:0007354) | 2.34814407 |
| 68 | Pigmentary retinal degeneration (HP:0001146) | 2.34810002 |
| 69 | Abnormality of oral frenula (HP:0000190) | 2.32067236 |
| 70 | Gastrointestinal infarctions (HP:0005244) | 2.31925220 |
| 71 | Purpura (HP:0000979) | 2.31762359 |
| 72 | Recurrent skin infections (HP:0001581) | 2.28257643 |
| 73 | Abnormal platelet volume (HP:0011876) | 2.25488777 |
| 74 | Keratitis (HP:0000491) | 2.24868561 |
| 75 | Increased IgE level (HP:0003212) | 2.24098025 |
| 76 | Recurrent otitis media (HP:0000403) | 2.22969649 |
| 77 | Hypergammaglobulinemia (HP:0010702) | 2.21853332 |
| 78 | Ureteral obstruction (HP:0006000) | 2.16887089 |
| 79 | Hemiplegia (HP:0002301) | 2.13793733 |
| 80 | Vasculitis (HP:0002633) | 2.13763172 |
| 81 | Episodic fever (HP:0001954) | 2.11814528 |
| 82 | Epistaxis (HP:0000421) | 2.10545022 |
| 83 | Retrobulbar optic neuritis (HP:0100654) | 2.08850247 |
| 84 | Optic neuritis (HP:0100653) | 2.08850247 |
| 85 | Papilledema (HP:0001085) | 2.07839364 |
| 86 | Bicuspid aortic valve (HP:0001647) | 2.07816555 |
| 87 | Chronic obstructive pulmonary disease (HP:0006510) | 2.07713976 |
| 88 | Obstructive lung disease (HP:0006536) | 2.07713976 |
| 89 | Urticaria (HP:0001025) | 2.07342111 |
| 90 | Malignant hyperthermia (HP:0002047) | 2.04938639 |
| 91 | Chronic sinusitis (HP:0011109) | 2.04654393 |
| 92 | IgA deficiency (HP:0002720) | 2.04246793 |
| 93 | Pulmonary infiltrates (HP:0002113) | 2.02839971 |
| 94 | Hypoalbuminemia (HP:0003073) | 2.01338523 |
| 95 | Abnormal albumin level (HP:0012116) | 2.01338523 |
| 96 | Hemoptysis (HP:0002105) | 1.99107377 |
| 97 | Prolonged bleeding time (HP:0003010) | 1.98499668 |
| 98 | Sepsis (HP:0100806) | 1.97570081 |
| 99 | Orchitis (HP:0100796) | 1.95563007 |
| 100 | Aplasia/Hypoplasia of the thymus (HP:0010515) | 1.95168784 |
| 101 | Skin rash (HP:0000988) | 1.94926767 |
| 102 | Keratoconjunctivitis sicca (HP:0001097) | 1.94657603 |
| 103 | Recurrent gram-negative bacterial infections (HP:0005420) | 1.93202879 |
| 104 | Recurrent bacterial skin infections (HP:0005406) | 1.93059740 |
| 105 | Amaurosis fugax (HP:0100576) | 1.91258583 |
| 106 | Increased mean platelet volume (HP:0011877) | 1.91180730 |
| 107 | Abnormality of the pleura (HP:0002103) | 1.90350752 |
| 108 | Lower limb hyperreflexia (HP:0002395) | 1.90046002 |
| 109 | Broad palm (HP:0001169) | 1.89518529 |
| 110 | Cutis marmorata (HP:0000965) | 1.89091431 |
| 111 | Colitis (HP:0002583) | 1.88753066 |
| 112 | Premature loss of primary teeth (HP:0006323) | 1.87168802 |
| 113 | Palpebral edema (HP:0100540) | 1.86878798 |
| 114 | Glomerulopathy (HP:0100820) | 1.84807361 |
| 115 | Toxemia of pregnancy (HP:0100603) | 1.83026857 |
| 116 | Chest pain (HP:0100749) | 1.82129750 |
| 117 | Radial bowing (HP:0002986) | 1.82073113 |
| 118 | Trigonocephaly (HP:0000243) | 1.81511405 |
| 119 | Gingivitis (HP:0000230) | 1.80721883 |
| 120 | Dislocated radial head (HP:0003083) | 1.78609518 |
| 121 | Pulmonary embolism (HP:0002204) | 1.78416295 |
| 122 | Gingival bleeding (HP:0000225) | 1.75286725 |
| 123 | Arterial thrombosis (HP:0004420) | 1.75043944 |
| 124 | Cellular immunodeficiency (HP:0005374) | 1.74791940 |
| 125 | Abnormality of the prostate (HP:0008775) | 1.73721088 |
| 126 | Bronchiectasis (HP:0002110) | 1.73146528 |
| 127 | Alveolar cell carcinoma (HP:0006519) | 1.72579037 |
| 128 | Keratoconjunctivitis (HP:0001096) | 1.72510154 |
| 129 | Striae distensae (HP:0001065) | 1.69075486 |
| 130 | Ureteral stenosis (HP:0000071) | 1.67200496 |
| 131 | Hepatitis (HP:0012115) | 1.66266917 |
| 132 | Abnormality of the radial head (HP:0003995) | 1.65387842 |
| 133 | Periodontitis (HP:0000704) | 1.65047829 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | TXK | 6.79475205 |
| 2 | MAP4K1 | 5.86462720 |
| 3 | ITK | 3.76635636 |
| 4 | STK10 | 3.22318008 |
| 5 | ZAP70 | 2.94965139 |
| 6 | JAK3 | 2.84998286 |
| 7 | GRK6 | 2.65232073 |
| 8 | FGFR4 | 2.49890118 |
| 9 | CAMKK2 | 2.40566397 |
| 10 | TYK2 | 2.36514701 |
| 11 | EEF2K | 2.16811964 |
| 12 | NLK | 2.06261331 |
| 13 | IKBKE | 1.98027506 |
| 14 | CSK | 1.94094202 |
| 15 | JAK1 | 1.93232075 |
| 16 | MST4 | 1.92842408 |
| 17 | LCK | 1.87907207 |
| 18 | TEC | 1.81157928 |
| 19 | BMPR2 | 1.80020956 |
| 20 | FGFR3 | 1.76947914 |
| 21 | RIPK4 | 1.68145063 |
| 22 | SCYL2 | 1.61528044 |
| 23 | TESK1 | 1.59875591 |
| 24 | MAP3K13 | 1.58982548 |
| 25 | MAP3K10 | 1.56494697 |
| 26 | SYK | 1.55475530 |
| 27 | MAP3K11 | 1.49984866 |
| 28 | LRRK2 | 1.47563431 |
| 29 | TAOK3 | 1.46347443 |
| 30 | CAMKK1 | 1.43955925 |
| 31 | BTK | 1.40491164 |
| 32 | HCK | 1.32970118 |
| 33 | MAP3K14 | 1.32546562 |
| 34 | PKN2 | 1.29886880 |
| 35 | PRKCH | 1.26393558 |
| 36 | PRKCQ | 1.26323023 |
| 37 | MARK3 | 1.01732738 |
| 38 | TBK1 | 1.01305024 |
| 39 | MAP3K7 | 1.00872139 |
| 40 | IKBKB | 0.98356072 |
| 41 | PIM1 | 0.96989921 |
| 42 | EPHB1 | 0.96602489 |
| 43 | CLK1 | 0.96295359 |
| 44 | SIK2 | 0.96148047 |
| 45 | FGR | 0.95166607 |
| 46 | MARK2 | 0.87305262 |
| 47 | STK38 | 0.86076353 |
| 48 | FES | 0.81818771 |
| 49 | CDK19 | 0.80624646 |
| 50 | BLK | 0.79979341 |
| 51 | CDK4 | 0.79396472 |
| 52 | PDGFRB | 0.78952536 |
| 53 | DMPK | 0.78426401 |
| 54 | PASK | 0.75964184 |
| 55 | STK4 | 0.75528726 |
| 56 | JAK2 | 0.75360960 |
| 57 | NME2 | 0.74227051 |
| 58 | BCKDK | 0.74146026 |
| 59 | LIMK1 | 0.73555460 |
| 60 | KIT | 0.73478899 |
| 61 | MAPKAPK3 | 0.71409489 |
| 62 | IRAK4 | 0.70345254 |
| 63 | TRIB3 | 0.69867373 |
| 64 | FLT3 | 0.68666549 |
| 65 | TGFBR2 | 0.67009113 |
| 66 | FGFR1 | 0.66097138 |
| 67 | LYN | 0.64004697 |
| 68 | MELK | 0.62632865 |
| 69 | TYRO3 | 0.62087093 |
| 70 | BMX | 0.60978755 |
| 71 | HIPK2 | 0.60825646 |
| 72 | DAPK1 | 0.60659122 |
| 73 | TAOK1 | 0.58517161 |
| 74 | GRK7 | 0.58336513 |
| 75 | TESK2 | 0.58071866 |
| 76 | TGFBR1 | 0.56691048 |
| 77 | ALK | 0.55825136 |
| 78 | MAP3K12 | 0.55266430 |
| 79 | RPS6KA4 | 0.54901039 |
| 80 | PDK1 | 0.54727966 |
| 81 | MAPK7 | 0.53338457 |
| 82 | CSF1R | 0.53316047 |
| 83 | RPS6KB2 | 0.51725084 |
| 84 | STK38L | 0.51671601 |
| 85 | FYN | 0.51110850 |
| 86 | STK11 | 0.50398791 |
| 87 | PRKD2 | 0.49985371 |
| 88 | PTK6 | 0.49869427 |
| 89 | CDK12 | 0.49703598 |
| 90 | CDK6 | 0.48834073 |
| 91 | CDC7 | 0.47283893 |
| 92 | CDK9 | 0.47215703 |
| 93 | FGFR2 | 0.46724808 |
| 94 | KDR | 0.46380654 |
| 95 | INSR | 0.46221185 |
| 96 | TNK2 | 0.45827583 |
| 97 | IGF1R | 0.44537231 |
| 98 | TSSK6 | 0.42794251 |
| 99 | EPHA3 | 0.40452943 |
| 100 | MAPK12 | 0.40181390 |
| 101 | MAP2K6 | 0.39395855 |
| 102 | MAP3K3 | 0.39270065 |
| 103 | NUAK1 | 0.37347063 |
| 104 | CHUK | 0.37073839 |
| 105 | PIK3CG | 0.37004788 |
| 106 | MAPK4 | 0.35194420 |
| 107 | MAP3K8 | 0.35093723 |
| 108 | MAPK3 | 0.33898706 |
| 109 | MAPK11 | 0.33606231 |
| 110 | CAMK4 | 0.33094253 |
| 111 | TTN | 0.31698243 |
| 112 | NEK6 | 0.31052960 |
| 113 | EGFR | 0.29598805 |
| 114 | NTRK2 | 0.29509172 |
| 115 | MAPK9 | 0.29487903 |
| 116 | SIK3 | 0.28854905 |
| 117 | ATR | 0.27953623 |
| 118 | MAP3K6 | 0.26515814 |
| 119 | PRPF4B | 0.25122151 |
| 120 | TRPM7 | 0.24872225 |
| 121 | SGK3 | 0.24612526 |
| 122 | ILK | 0.23440478 |
| 123 | IRAK1 | 0.23218946 |
| 124 | ROCK2 | 0.22955625 |
| 125 | MAP2K3 | 0.22825997 |
| 126 | RET | 0.22818026 |
| 127 | SRPK1 | 0.22115631 |
| 128 | VRK2 | 0.21751425 |
| 129 | RPS6KA6 | 0.21200683 |
| 130 | PRKCI | 0.21145373 |
| 131 | TLK1 | 0.20971431 |
| 132 | ADRBK2 | 0.17396565 |
| 133 | CDC42BPA | 0.16568678 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Primary immunodeficiency_Homo sapiens_hsa05340 | 5.77855089 |
| 2 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 4.63920580 |
| 3 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 3.48108723 |
| 4 | Graft-versus-host disease_Homo sapiens_hsa05332 | 3.19696414 |
| 5 | Measles_Homo sapiens_hsa05162 | 2.92553535 |
| 6 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 2.67781575 |
| 7 | Antigen processing and presentation_Homo sapiens_hsa04612 | 2.63102792 |
| 8 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 2.48139421 |
| 9 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 2.39577931 |
| 10 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 2.31268715 |
| 11 | Allograft rejection_Homo sapiens_hsa05330 | 2.26081856 |
| 12 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 1.87880977 |
| 13 | Osteoclast differentiation_Homo sapiens_hsa04380 | 1.82545324 |
| 14 | Viral myocarditis_Homo sapiens_hsa05416 | 1.73278162 |
| 15 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.71753003 |
| 16 | Leishmaniasis_Homo sapiens_hsa05140 | 1.69286375 |
| 17 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 1.59046409 |
| 18 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 1.51879624 |
| 19 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 1.51665198 |
| 20 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 1.50504757 |
| 21 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 1.48258449 |
| 22 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 1.46349564 |
| 23 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 1.44264565 |
| 24 | Herpes simplex infection_Homo sapiens_hsa05168 | 1.43890513 |
| 25 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 1.41821295 |
| 26 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 1.38794136 |
| 27 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 1.32348634 |
| 28 | Ribosome_Homo sapiens_hsa03010 | 1.26477254 |
| 29 | Pancreatic cancer_Homo sapiens_hsa05212 | 1.24397026 |
| 30 | Toxoplasmosis_Homo sapiens_hsa05145 | 1.23606617 |
| 31 | Hepatitis B_Homo sapiens_hsa05161 | 1.21053671 |
| 32 | Colorectal cancer_Homo sapiens_hsa05210 | 1.21033866 |
| 33 | HTLV-I infection_Homo sapiens_hsa05166 | 1.20568280 |
| 34 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 1.16897124 |
| 35 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 1.15092751 |
| 36 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 1.13162982 |
| 37 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 1.12460344 |
| 38 | Apoptosis_Homo sapiens_hsa04210 | 1.09575901 |
| 39 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 1.07321747 |
| 40 | TNF signaling pathway_Homo sapiens_hsa04668 | 1.04844948 |
| 41 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.04485437 |
| 42 | Viral carcinogenesis_Homo sapiens_hsa05203 | 1.01545497 |
| 43 | Platelet activation_Homo sapiens_hsa04611 | 0.99775253 |
| 44 | Influenza A_Homo sapiens_hsa05164 | 0.98849417 |
| 45 | Shigellosis_Homo sapiens_hsa05131 | 0.97595491 |
| 46 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 0.96613728 |
| 47 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.95696135 |
| 48 | Proteasome_Homo sapiens_hsa03050 | 0.86114953 |
| 49 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.85130235 |
| 50 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.79724631 |
| 51 | Hepatitis C_Homo sapiens_hsa05160 | 0.78539169 |
| 52 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.78167440 |
| 53 | Spliceosome_Homo sapiens_hsa03040 | 0.76706604 |
| 54 | Thyroid cancer_Homo sapiens_hsa05216 | 0.76483713 |
| 55 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.75903186 |
| 56 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.70144554 |
| 57 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.69750516 |
| 58 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.66636454 |
| 59 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.66507513 |
| 60 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.64435871 |
| 61 | Asthma_Homo sapiens_hsa05310 | 0.64174893 |
| 62 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.63704123 |
| 63 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.62426234 |
| 64 | DNA replication_Homo sapiens_hsa03030 | 0.60665650 |
| 65 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.59449982 |
| 66 | Endometrial cancer_Homo sapiens_hsa05213 | 0.59242691 |
| 67 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.59241401 |
| 68 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.58827357 |
| 69 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.57422478 |
| 70 | Mismatch repair_Homo sapiens_hsa03430 | 0.56583422 |
| 71 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.56346403 |
| 72 | Salmonella infection_Homo sapiens_hsa05132 | 0.54961978 |
| 73 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 0.54876170 |
| 74 | Legionellosis_Homo sapiens_hsa05134 | 0.54331753 |
| 75 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.53842160 |
| 76 | Tuberculosis_Homo sapiens_hsa05152 | 0.53061957 |
| 77 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.52825807 |
| 78 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.52037323 |
| 79 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.51527693 |
| 80 | Prostate cancer_Homo sapiens_hsa05215 | 0.48257614 |
| 81 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.48147883 |
| 82 | Endocytosis_Homo sapiens_hsa04144 | 0.46023029 |
| 83 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.44894884 |
| 84 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.44795107 |
| 85 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.44722229 |
| 86 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.42103544 |
| 87 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.41885528 |
| 88 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.41329809 |
| 89 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.40762192 |
| 90 | Malaria_Homo sapiens_hsa05144 | 0.40196698 |
| 91 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.39251443 |
| 92 | Base excision repair_Homo sapiens_hsa03410 | 0.38620811 |
| 93 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.38172385 |
| 94 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.37821813 |
| 95 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 0.36565447 |
| 96 | Insulin resistance_Homo sapiens_hsa04931 | 0.36046838 |
| 97 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.36016805 |
| 98 | RNA degradation_Homo sapiens_hsa03018 | 0.35777417 |
| 99 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.34328197 |
| 100 | Phagosome_Homo sapiens_hsa04145 | 0.33936949 |
| 101 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.33173648 |
| 102 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.32470396 |
| 103 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.31691409 |
| 104 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.31157616 |
| 105 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.31048660 |
| 106 | Pertussis_Homo sapiens_hsa05133 | 0.30986915 |
| 107 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.29984051 |
| 108 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.29812182 |
| 109 | Morphine addiction_Homo sapiens_hsa05032 | 0.28672596 |
| 110 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 0.27674814 |
| 111 | Homologous recombination_Homo sapiens_hsa03440 | 0.26235918 |
| 112 | Olfactory transduction_Homo sapiens_hsa04740 | 0.25719769 |
| 113 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.25387591 |
| 114 | Cell cycle_Homo sapiens_hsa04110 | 0.24759227 |
| 115 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.24706341 |
| 116 | Pathways in cancer_Homo sapiens_hsa05200 | 0.24690809 |
| 117 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.24403042 |
| 118 | RNA transport_Homo sapiens_hsa03013 | 0.23340349 |
| 119 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.23338275 |
| 120 | Long-term potentiation_Homo sapiens_hsa04720 | 0.23302623 |
| 121 | Adherens junction_Homo sapiens_hsa04520 | 0.23183436 |
| 122 | Alcoholism_Homo sapiens_hsa05034 | 0.22301130 |
| 123 | Lysine degradation_Homo sapiens_hsa00310 | 0.21736582 |
| 124 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.19509064 |
| 125 | Parkinsons disease_Homo sapiens_hsa05012 | 0.18021515 |
| 126 | Amphetamine addiction_Homo sapiens_hsa05031 | 0.17369230 |
| 127 | Phototransduction_Homo sapiens_hsa04744 | 0.16682782 |
| 128 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.16636064 |
| 129 | Basal transcription factors_Homo sapiens_hsa03022 | 0.15965898 |
| 130 | RNA polymerase_Homo sapiens_hsa03020 | 0.15827922 |

