TRBJ2-2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of B cell receptor signaling pathway (GO:0050855)6.08442341
2cytidine deamination (GO:0009972)5.99489450
3cytidine metabolic process (GO:0046087)5.99489450
4cytidine catabolic process (GO:0006216)5.99489450
5positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)5.98021866
6positive regulation of natural killer cell mediated immunity (GO:0002717)5.87207483
7Arp2/3 complex-mediated actin nucleation (GO:0034314)5.81104322
8positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.78148617
9regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.32755312
10DNA deamination (GO:0045006)5.28823748
11pyrimidine ribonucleoside catabolic process (GO:0046133)5.26008032
12positive thymic T cell selection (GO:0045059)5.20286878
13regulation of natural killer cell mediated cytotoxicity (GO:0042269)5.19171183
14regulation of natural killer cell mediated immunity (GO:0002715)5.19171183
15actin nucleation (GO:0045010)4.95914431
16positive T cell selection (GO:0043368)4.83054066
17antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.80275951
18cellular response to interleukin-15 (GO:0071350)4.59461911
19deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.49526959
20positive regulation of leukocyte mediated cytotoxicity (GO:0001912)4.40584475
21cytolysis (GO:0019835)4.27118609
22positive regulation of gamma-delta T cell activation (GO:0046645)4.20543271
23negative T cell selection (GO:0043383)4.20359180
24regulation of gamma-delta T cell differentiation (GO:0045586)4.11105562
25T cell migration (GO:0072678)4.08454946
26positive regulation of calcium-mediated signaling (GO:0050850)4.07772139
27regulation of leukocyte mediated cytotoxicity (GO:0001910)3.95488452
28iron-sulfur cluster assembly (GO:0016226)3.87369448
29metallo-sulfur cluster assembly (GO:0031163)3.87369448
30thymic T cell selection (GO:0045061)3.86873856
31negative regulation of T cell apoptotic process (GO:0070233)3.84397872
32positive regulation of cell killing (GO:0031343)3.81774134
33regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.79682543
34positive regulation of B cell differentiation (GO:0045579)3.79552830
35sequestering of actin monomers (GO:0042989)3.78617454
36negative regulation of oxidoreductase activity (GO:0051354)3.74351494
37negative thymic T cell selection (GO:0045060)3.73282910
38purine deoxyribonucleotide catabolic process (GO:0009155)3.72523362
39regulation of RIG-I signaling pathway (GO:0039535)3.70098925
40negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.61589847
41deoxyribonucleoside diphosphate metabolic process (GO:0009186)3.61384900
42deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.59368636
43regulation of activation of Janus kinase activity (GO:0010533)3.56485893
44negative regulation of viral genome replication (GO:0045071)3.55696500
45negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.51217375
46T cell selection (GO:0045058)3.50633794
47mast cell degranulation (GO:0043303)3.48321494
48mast cell activation involved in immune response (GO:0002279)3.48321494
49respiratory burst (GO:0045730)3.48272563
50negative regulation of stress fiber assembly (GO:0051497)3.48204869
51T cell receptor signaling pathway (GO:0050852)3.46873112
52regulation of cell killing (GO:0031341)3.46204792
53response to interleukin-15 (GO:0070672)3.45317751
54regulation of T cell receptor signaling pathway (GO:0050856)3.44944902
55pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.43522396
56protein maturation by protein folding (GO:0022417)3.39908540
57pyrimidine nucleoside catabolic process (GO:0046135)3.39141690
58deoxyribonucleotide catabolic process (GO:0009264)3.38896812
59ribosomal small subunit assembly (GO:0000028)3.36837949
60response to interferon-beta (GO:0035456)3.36640590
61regulation of regulatory T cell differentiation (GO:0045589)3.34817929
62positive regulation of lamellipodium assembly (GO:0010592)3.32535954
63positive regulation of T cell apoptotic process (GO:0070234)3.30704958
64deoxyribose phosphate catabolic process (GO:0046386)3.30180656
65regulation of gamma-delta T cell activation (GO:0046643)3.28009021
66natural killer cell activation (GO:0030101)3.26965197
67purine deoxyribonucleotide metabolic process (GO:0009151)3.26711395
68antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.26422868
69mast cell activation (GO:0045576)3.23460238
70deoxyribose phosphate biosynthetic process (GO:0046385)3.23351900
712-deoxyribonucleotide biosynthetic process (GO:0009265)3.23351900
72T cell costimulation (GO:0031295)3.22087703
73purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)3.18459706
74lymphocyte costimulation (GO:0031294)3.18160787
75antigen receptor-mediated signaling pathway (GO:0050851)3.10998122
76regulation of cellular amino acid metabolic process (GO:0006521)3.09163864
77regulation of T cell apoptotic process (GO:0070232)3.08806513
78negative regulation of lymphocyte apoptotic process (GO:0070229)3.08608185
792-deoxyribonucleotide metabolic process (GO:0009394)3.08086920
80positive regulation of tolerance induction (GO:0002645)3.07793581
81macrophage chemotaxis (GO:0048246)3.07745874
82regulation of T cell tolerance induction (GO:0002664)3.07478314
83regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.07121033
84antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.06188165
85DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.04990547
86regulation of calcium-mediated signaling (GO:0050848)3.03270217
87mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.01401738
88positive regulation of granulocyte differentiation (GO:0030854)3.01077936
89signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.95566229
90signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.95566229
91signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.95566229
92signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.94773324
93intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.94773324
94immunoglobulin mediated immune response (GO:0016064)2.94197220
95deoxyribose phosphate metabolic process (GO:0019692)2.93776249
96positive regulation of monocyte chemotaxis (GO:0090026)2.92765691
97negative regulation of monooxygenase activity (GO:0032769)2.91652527
98regulation of B cell differentiation (GO:0045577)2.90983608
99pyrimidine nucleotide catabolic process (GO:0006244)2.90317159
100positive regulation of defense response to virus by host (GO:0002230)2.88731707

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.62294988
2IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.31903681
3ELF1_17652178_ChIP-ChIP_JURKAT_Human4.24014736
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.18935891
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.82841784
6IRF8_21731497_ChIP-ChIP_J774_Mouse3.65798197
7BP1_19119308_ChIP-ChIP_Hs578T_Human3.29837683
8RUNX1_20887958_ChIP-Seq_HPC-7_Mouse3.19108085
9MYB_26560356_Chip-Seq_TH2_Human3.02791823
10FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.81853302
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.77578760
12SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.71105002
13TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.64335731
14SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.59887369
15LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.44749971
16UTX_26944678_Chip-Seq_JUKART_Human2.44247736
17RUNX_20019798_ChIP-Seq_JUKART_Human2.36405936
18FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.23121814
19RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.19616839
20STAT4_19710469_ChIP-ChIP_TH1__Mouse2.18881465
21MYB_26560356_Chip-Seq_TH1_Human2.18339711
22GATA3_27048872_Chip-Seq_THYMUS_Human2.10738022
23MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.94751639
24FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.93731558
25STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.87639405
26MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.87533017
27VDR_23849224_ChIP-Seq_CD4+_Human1.85264250
28CIITA_25753668_ChIP-Seq_RAJI_Human1.84815349
29BCL6_27268052_Chip-Seq_Bcells_Human1.82674511
30MAF_26560356_Chip-Seq_TH1_Human1.81063172
31MAF_26560356_Chip-Seq_TH2_Human1.77153347
32GATA3_26560356_Chip-Seq_TH2_Human1.75947200
33LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.64609843
34SPI1_23547873_ChIP-Seq_NB4_Human1.64414223
35RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.60994686
36JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.60286671
37SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.54632346
38GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.54549244
39FOXP3_21729870_ChIP-Seq_TREG_Human1.50044112
40HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.48788827
41E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.47189393
42TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.39825896
43RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.38175311
44P300_27268052_Chip-Seq_Bcells_Human1.37248039
45EST1_17652178_ChIP-ChIP_JURKAT_Human1.34199291
46GABP_17652178_ChIP-ChIP_JURKAT_Human1.32704142
47EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.31128011
48BCOR_27268052_Chip-Seq_Bcells_Human1.30951276
49SA1_27219007_Chip-Seq_Bcells_Human1.28682792
50TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.28141745
51SRF_21415370_ChIP-Seq_HL-1_Mouse1.25736038
52FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.25728449
53NOTCH1_21737748_ChIP-Seq_TLL_Human1.22180169
54ELF1_20517297_ChIP-Seq_JURKAT_Human1.19938591
55ETS1_20019798_ChIP-Seq_JURKAT_Human1.17391482
56CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.17321374
57PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.15673971
58IRF8_27001747_Chip-Seq_BMDM_Mouse1.15527214
59EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.15174883
60CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.14709809
61KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.13849058
62YY1_21170310_ChIP-Seq_MESCs_Mouse1.13152957
63NANOG_20526341_ChIP-Seq_ESCs_Human1.12464822
64HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.11696867
65PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.10690996
66RUNX1_22412390_ChIP-Seq_EML_Mouse1.03723089
67MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.03206554
68E2F1_20622854_ChIP-Seq_HELA_Human1.02418323
69VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.02030449
70E2F7_22180533_ChIP-Seq_HELA_Human1.01380186
71TAF2_19829295_ChIP-Seq_ESCs_Human1.01119274
72E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.00769328
73HOXB4_20404135_ChIP-ChIP_EML_Mouse0.99553353
74GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.95661919
75SPI1_20517297_ChIP-Seq_HL60_Human0.95348313
76CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.95341439
77HTT_18923047_ChIP-ChIP_STHdh_Human0.95011009
78SOX2_21211035_ChIP-Seq_LN229_Human0.94170179
79GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.93900796
80RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.93831713
81PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.92623050
82P53_21459846_ChIP-Seq_SAOS-2_Human0.92583132
83CEBPB_22108803_ChIP-Seq_LS180_Human0.91442759
84CTCF_20526341_ChIP-Seq_ESCs_Human0.91235028
85SCL_19346495_ChIP-Seq_HPC-7_Human0.91070187
86FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90389647
87VDR_24763502_ChIP-Seq_THP-1_Human0.89977401
88TP53_22573176_ChIP-Seq_HFKS_Human0.89771542
89LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.87581398
90CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.87064844
91AR_20517297_ChIP-Seq_VCAP_Human0.86678673
92RAC3_21632823_ChIP-Seq_H3396_Human0.86411528
93MYC_18358816_ChIP-ChIP_MESCs_Mouse0.85346607
94ERG_20517297_ChIP-Seq_VCAP_Human0.84315810
95SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.83535919
96GATA6_21074721_ChIP-Seq_CACO-2_Human0.83125195
97GATA2_22383799_ChIP-Seq_G1ME_Mouse0.82173036
98VDR_22108803_ChIP-Seq_LS180_Human0.82005961
99TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.81752709
100SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.81083236

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to6.67270317
2MP0005451_abnormal_body_composition5.48922539
3MP0003763_abnormal_thymus_physiology3.87068169
4MP0009785_altered_susceptibility_to3.44146269
5MP0001835_abnormal_antigen_presentation3.23628795
6MP0001873_stomach_inflammation3.13674347
7MP0002638_abnormal_pupillary_reflex2.73538640
8MP0005025_abnormal_response_to2.62421889
9MP0001800_abnormal_humoral_immune2.45722174
10MP0005000_abnormal_immune_tolerance2.44341374
11MP0002166_altered_tumor_susceptibility2.43110858
12MP0002420_abnormal_adaptive_immunity2.38240723
13MP0001819_abnormal_immune_cell2.30066011
14MP0009333_abnormal_splenocyte_physiolog2.29845778
15MP0002723_abnormal_immune_serum2.27690516
16MP0005387_immune_system_phenotype2.20012090
17MP0001790_abnormal_immune_system2.20012090
18MP0010155_abnormal_intestine_physiology2.17326540
19MP0002148_abnormal_hypersensitivity_rea2.04936177
20MP0005645_abnormal_hypothalamus_physiol2.01757028
21MP0003866_abnormal_defecation2.00364233
22MP0002452_abnormal_antigen_presenting1.99146822
23MP0000685_abnormal_immune_system1.97163924
24MP0002398_abnormal_bone_marrow1.92494629
25MP0002933_joint_inflammation1.91286261
26MP0000716_abnormal_immune_system1.84444335
27MP0002006_tumorigenesis1.82542014
28MP0002419_abnormal_innate_immunity1.73756956
29MP0003787_abnormal_imprinting1.70480847
30MP0002405_respiratory_system_inflammati1.66721948
31MP0001845_abnormal_inflammatory_respons1.63407614
32MP0000703_abnormal_thymus_morphology1.61766518
33MP0008875_abnormal_xenobiotic_pharmacok1.58551183
34MP0000689_abnormal_spleen_morphology1.55807570
35MP0000858_altered_metastatic_potential1.55562868
36MP0002722_abnormal_immune_system1.54660662
37MP0008260_abnormal_autophagy1.53164669
38MP0000372_irregular_coat_pigmentation1.45942862
39MP0003436_decreased_susceptibility_to1.45709181
40MP0002429_abnormal_blood_cell1.41281786
41MP0008469_abnormal_protein_level1.34828876
42MP0001905_abnormal_dopamine_level1.32485698
43MP0005075_abnormal_melanosome_morpholog1.32163545
44MP0008872_abnormal_physiological_respon1.30864096
45MP0001485_abnormal_pinna_reflex1.29286360
46MP0001764_abnormal_homeostasis1.28464862
47MP0003448_altered_tumor_morphology1.25630883
48MP0005646_abnormal_pituitary_gland1.25280594
49MP0005464_abnormal_platelet_physiology1.24909314
50MP0003724_increased_susceptibility_to1.24496004
51MP0006082_CNS_inflammation1.23301612
52MP0003878_abnormal_ear_physiology1.18169245
53MP0005377_hearing/vestibular/ear_phenot1.18169245
54MP0003283_abnormal_digestive_organ1.18045969
55MP0010386_abnormal_urinary_bladder1.14775569
56MP0004947_skin_inflammation1.10442485
57MP0000490_abnormal_crypts_of1.08582015
58MP0005166_decreased_susceptibility_to0.97110764
59MP0005551_abnormal_eye_electrophysiolog0.92612708
60MP0002019_abnormal_tumor_incidence0.90938663
61MP0009763_increased_sensitivity_to0.89074268
62MP0001533_abnormal_skeleton_physiology0.89064594
63MP0009384_cardiac_valve_regurgitation0.84638157
64MP0006036_abnormal_mitochondrial_physio0.84083501
65MP0009764_decreased_sensitivity_to0.81983591
66MP0005319_abnormal_enzyme/_coenzyme0.80512258
67MP0003183_abnormal_peptide_metabolism0.80463236
68MP0001666_abnormal_nutrient_absorption0.79603355
69MP0003806_abnormal_nucleotide_metabolis0.78165472
70MP0002102_abnormal_ear_morphology0.78006224
71MP0003075_altered_response_to0.76455372
72MP0001853_heart_inflammation0.76155970
73MP0001663_abnormal_digestive_system0.75357039
74MP0009643_abnormal_urine_homeostasis0.74606628
75MP0000639_abnormal_adrenal_gland0.73875191
76MP0001986_abnormal_taste_sensitivity0.73714111
77MP0004381_abnormal_hair_follicle0.72192949
78MP0002693_abnormal_pancreas_physiology0.72110801
79MP0003646_muscle_fatigue0.71394370
80MP0003252_abnormal_bile_duct0.71033667
81MP0003137_abnormal_impulse_conducting0.71025249
82MP0001501_abnormal_sleep_pattern0.70145410
83MP0002876_abnormal_thyroid_physiology0.69859241
84MP0004147_increased_porphyrin_level0.69365276
85MP0001919_abnormal_reproductive_system0.66466771
86MP0005410_abnormal_fertilization0.65138157
87MP0001542_abnormal_bone_strength0.63513765
88MP0003693_abnormal_embryo_hatching0.63147203
89MP0006276_abnormal_autonomic_nervous0.62937316
90MP0006035_abnormal_mitochondrial_morpho0.62725383
91MP0009697_abnormal_copulation0.62631745
92MP0001765_abnormal_ion_homeostasis0.61009524
93MP0005636_abnormal_mineral_homeostasis0.60856598
94MP0006072_abnormal_retinal_apoptosis0.60580854
95MP0002132_abnormal_respiratory_system0.57984291
96MP0008961_abnormal_basal_metabolism0.57507023
97MP0000230_abnormal_systemic_arterial0.56756286
98MP0004742_abnormal_vestibular_system0.54507375
99MP0000604_amyloidosis0.53835956
100MP0002277_abnormal_respiratory_mucosa0.52881235

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)6.43933830
2Severe combined immunodeficiency (HP:0004430)6.11139065
3Abnormality of T cell number (HP:0011839)5.75196285
4Abnormality of B cell number (HP:0010975)5.71006221
5Aplastic anemia (HP:0001915)5.67980160
6B lymphocytopenia (HP:0010976)5.67006330
7Increased IgM level (HP:0003496)5.61825304
8Combined immunodeficiency (HP:0005387)5.13295083
9IgG deficiency (HP:0004315)5.07370794
10Thyroiditis (HP:0100646)4.58986456
11Elevated erythrocyte sedimentation rate (HP:0003565)4.53386216
12Autoimmune hemolytic anemia (HP:0001890)4.45352792
13Hypoproteinemia (HP:0003075)4.32522566
14Chronic diarrhea (HP:0002028)4.19611815
15Abnormality of T cells (HP:0002843)3.99809637
16Hypoplasia of the thymus (HP:0000778)3.91214861
17Agammaglobulinemia (HP:0004432)3.79108470
18Encephalitis (HP:0002383)3.43152138
19Acute hepatic failure (HP:0006554)3.31997062
20Recurrent cutaneous fungal infections (HP:0011370)3.28142798
21Chronic mucocutaneous candidiasis (HP:0002728)3.28142798
22Myositis (HP:0100614)3.24887656
23Pancytopenia (HP:0001876)3.07178589
24Abnormality of eosinophils (HP:0001879)3.07143553
25Absent rod-and cone-mediated responses on ERG (HP:0007688)3.05682506
26Lymphopenia (HP:0001888)3.03809005
27Hypergammaglobulinemia (HP:0010702)3.01565894
28Stomatitis (HP:0010280)2.85525975
29Recurrent bronchitis (HP:0002837)2.77477446
30Meningitis (HP:0001287)2.77093259
31Abnormality of cells of the lymphoid lineage (HP:0012140)2.73941210
32Recurrent viral infections (HP:0004429)2.62356475
33Recurrent fungal infections (HP:0002841)2.61918618
34Cellular immunodeficiency (HP:0005374)2.59533085
35Obstructive lung disease (HP:0006536)2.58398805
36Chronic obstructive pulmonary disease (HP:0006510)2.58398805
37Abnormality of the prostate (HP:0008775)2.56995988
38Cerebral palsy (HP:0100021)2.55862019
39Autoimmune thrombocytopenia (HP:0001973)2.54985037
40Pigmentary retinal degeneration (HP:0001146)2.51576475
41Aplasia/Hypoplasia of the thymus (HP:0010515)2.47736654
42Abnormality of macrophages (HP:0004311)2.44153280
43Brushfield spots (HP:0001088)2.42431589
44Lymphoma (HP:0002665)2.36489587
45Increased intramyocellular lipid droplets (HP:0012240)2.34556377
46Mitochondrial inheritance (HP:0001427)2.33819849
47Spontaneous hematomas (HP:0007420)2.33446514
48Abnormal rod and cone electroretinograms (HP:0008323)2.33152166
49Leukocytosis (HP:0001974)2.28617525
50Granulocytopenia (HP:0001913)2.22786839
51Severe visual impairment (HP:0001141)2.18189535
52Bronchitis (HP:0012387)2.13290834
53Mediastinal lymphadenopathy (HP:0100721)2.11752577
54Oligomenorrhea (HP:0000876)2.10157033
55Decreased central vision (HP:0007663)2.09029267
56Keratoconus (HP:0000563)2.08152612
57Increased corneal curvature (HP:0100692)2.08152612
58Increased muscle lipid content (HP:0009058)2.07500336
59Erythema (HP:0010783)2.07310526
60Pustule (HP:0200039)2.06286736
61Panhypogammaglobulinemia (HP:0003139)2.06030715
62Recurrent skin infections (HP:0001581)2.05074722
63Joint swelling (HP:0001386)2.02959050
64Alkalosis (HP:0001948)2.02788617
65Increased hepatocellular lipid droplets (HP:0006565)2.02688695
66Congenital stationary night blindness (HP:0007642)2.01087399
67Skin rash (HP:0000988)1.97175027
68Neutropenia (HP:0001875)1.94760289
69Pulmonary infiltrates (HP:0002113)1.94175607
70Keratoconjunctivitis sicca (HP:0001097)1.93790814
71Eosinophilia (HP:0001880)1.92563737
72Abnormality of the pleura (HP:0002103)1.92109686
73Biconcave vertebral bodies (HP:0004586)1.90735610
74IgM deficiency (HP:0002850)1.87677194
75Orchitis (HP:0100796)1.86055012
76Constricted visual fields (HP:0001133)1.85326762
77Attenuation of retinal blood vessels (HP:0007843)1.85132093
78Retrobulbar optic neuritis (HP:0100654)1.82228961
79Optic neuritis (HP:0100653)1.82228961
80Gastrointestinal infarctions (HP:0005244)1.81657667
81Acute necrotizing encephalopathy (HP:0006965)1.80375423
82Vasculitis (HP:0002633)1.80264139
83Glucose intolerance (HP:0000833)1.79979156
84Abnormal mitochondria in muscle tissue (HP:0008316)1.79877239
85Palpebral edema (HP:0100540)1.77087922
86Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.76399581
87Interstitial pulmonary disease (HP:0006530)1.75970545
88Abolished electroretinogram (ERG) (HP:0000550)1.75316336
89Keratoconjunctivitis (HP:0001096)1.74878615
90Purpura (HP:0000979)1.73909459
91Hemoptysis (HP:0002105)1.73048757
923-Methylglutaconic aciduria (HP:0003535)1.72134395
93Chronic otitis media (HP:0000389)1.71796215
94Increased IgE level (HP:0003212)1.71159978
95Recurrent otitis media (HP:0000403)1.70224549
96Abnormality of T cell physiology (HP:0011840)1.69965139
97Abnormal delayed hypersensitivity skin test (HP:0002963)1.68996728
98Lipid accumulation in hepatocytes (HP:0006561)1.68975596
99Abnormality of the thymus (HP:0000777)1.68762103
100Decreased electroretinogram (ERG) amplitude (HP:0000654)1.64966061

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK25.37186991
2KDR5.18678725
3ZAK4.25424715
4TXK3.91861315
5TAOK33.55565995
6TLK13.23466235
7VRK13.19510392
8TESK12.84237528
9MAP4K12.82592275
10VRK22.60827839
11MAP3K112.54095240
12MAP3K122.41908386
13SCYL22.39184976
14TNK22.35687425
15CDK81.92431872
16LIMK11.86812324
17ITK1.84840983
18BCKDK1.76187866
19GRK71.75991861
20FES1.61719579
21TEC1.60359218
22ADRBK21.53144625
23PASK1.51109723
24MAP4K21.48521097
25BTK1.45099739
26SYK1.24033426
27KIT1.19297459
28ZAP701.13514117
29RPS6KA41.03264841
30TBK11.02031702
31MST41.01712243
32GRK60.99167517
33CSF1R0.99116367
34IKBKE0.92257298
35LCK0.89221681
36GRK10.86260529
37LYN0.85264044
38PRKCQ0.82797223
39MYLK0.82719772
40CSK0.81883583
41DAPK10.78420351
42JAK30.77260477
43PRKCH0.75970238
44SIK30.74973765
45MAP2K60.70051808
46MELK0.68885621
47NEK10.63291583
48NME20.61367538
49PIK3CG0.57784779
50LRRK20.57720214
51CDK40.55005389
52PIM10.54273754
53IRAK40.54235849
54TGFBR20.52654755
55AURKA0.52542613
56CLK10.51088774
57NLK0.49659743
58PRKD30.49231085
59GRK50.48354005
60FYN0.48293351
61RPS6KA50.48180724
62TNIK0.46797516
63HCK0.46181898
64TRPM70.45640286
65NUAK10.45543696
66CDK90.41667671
67INSRR0.37784266
68STK100.37746701
69DYRK1B0.36485142
70TAF10.35691279
71RIPK10.35286420
72JAK20.33812616
73PRKCA0.33155967
74MARK30.32840489
75ERN10.32413845
76IGF1R0.32055478
77MAP3K70.29349680
78ROCK10.29176597
79ATR0.28790501
80CSNK1G30.27350866
81INSR0.26852542
82OBSCN0.25904605
83TYRO30.25804906
84PAK10.25758007
85ADRBK10.25232386
86IKBKB0.24604209
87PKN10.24122197
88PRKCD0.23401278
89PRKACA0.22308371
90MAPK130.21413117
91TIE10.21358289
92PRKD20.20630032
93NTRK20.19673222
94PIK3CA0.19133334
95CSNK2A10.18612573
96TYK20.17463912
97CSNK1A1L0.15806563
98SRC0.15768111
99CAMKK10.15547216
100MAPK110.15485843

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053407.32771492
2Proteasome_Homo sapiens_hsa030504.23475565
3Antigen processing and presentation_Homo sapiens_hsa046123.12812464
4Oxidative phosphorylation_Homo sapiens_hsa001902.92964271
5Hematopoietic cell lineage_Homo sapiens_hsa046402.82521842
6Parkinsons disease_Homo sapiens_hsa050122.64914494
7Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.61904195
8Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.56536543
9Graft-versus-host disease_Homo sapiens_hsa053322.46770665
10T cell receptor signaling pathway_Homo sapiens_hsa046602.31866777
11Ribosome_Homo sapiens_hsa030102.23808225
12Homologous recombination_Homo sapiens_hsa034401.97929047
13Autoimmune thyroid disease_Homo sapiens_hsa053201.90824742
14Allograft rejection_Homo sapiens_hsa053301.79370965
15Alzheimers disease_Homo sapiens_hsa050101.67172963
16Malaria_Homo sapiens_hsa051441.64857245
17Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.62888529
18Measles_Homo sapiens_hsa051621.61233198
19Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.54063747
20Caffeine metabolism_Homo sapiens_hsa002321.50803650
21Huntingtons disease_Homo sapiens_hsa050161.48594325
22RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.39861771
23RNA polymerase_Homo sapiens_hsa030201.37956612
24Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.37208709
25Peroxisome_Homo sapiens_hsa041461.34137261
26One carbon pool by folate_Homo sapiens_hsa006701.33970509
27Cardiac muscle contraction_Homo sapiens_hsa042601.32910903
28Type I diabetes mellitus_Homo sapiens_hsa049401.28848528
29Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.25412653
30Shigellosis_Homo sapiens_hsa051311.23072233
31DNA replication_Homo sapiens_hsa030301.22570332
32Phototransduction_Homo sapiens_hsa047441.17563405
33Mismatch repair_Homo sapiens_hsa034301.16607111
34NF-kappa B signaling pathway_Homo sapiens_hsa040641.15719653
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.03043419
36Olfactory transduction_Homo sapiens_hsa047400.99002869
37Viral myocarditis_Homo sapiens_hsa054160.98860400
38Linoleic acid metabolism_Homo sapiens_hsa005910.97859913
39Salmonella infection_Homo sapiens_hsa051320.96003915
40Intestinal immune network for IgA production_Homo sapiens_hsa046720.93331836
41Steroid hormone biosynthesis_Homo sapiens_hsa001400.85463800
42Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.84862490
43Non-homologous end-joining_Homo sapiens_hsa034500.83279816
44Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.82612392
45Regulation of autophagy_Homo sapiens_hsa041400.80516951
46Fanconi anemia pathway_Homo sapiens_hsa034600.78686421
47Pyrimidine metabolism_Homo sapiens_hsa002400.77443691
48Purine metabolism_Homo sapiens_hsa002300.76474473
49Rheumatoid arthritis_Homo sapiens_hsa053230.75921273
50Base excision repair_Homo sapiens_hsa034100.75693751
51Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.75471024
52Asthma_Homo sapiens_hsa053100.75315999
53alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.75229973
54Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.74168485
55Systemic lupus erythematosus_Homo sapiens_hsa053220.73869454
56Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.73325094
57Herpes simplex infection_Homo sapiens_hsa051680.71255528
58Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.68715889
59SNARE interactions in vesicular transport_Homo sapiens_hsa041300.66928971
60Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.60434335
61Osteoclast differentiation_Homo sapiens_hsa043800.59550789
62Staphylococcus aureus infection_Homo sapiens_hsa051500.59495675
63Chemical carcinogenesis_Homo sapiens_hsa052040.58882940
64Ether lipid metabolism_Homo sapiens_hsa005650.52151550
65Nucleotide excision repair_Homo sapiens_hsa034200.49753444
66Nitrogen metabolism_Homo sapiens_hsa009100.49325788
67Toll-like receptor signaling pathway_Homo sapiens_hsa046200.47893783
68TNF signaling pathway_Homo sapiens_hsa046680.46324298
69Leishmaniasis_Homo sapiens_hsa051400.45605242
70RNA degradation_Homo sapiens_hsa030180.45366570
71Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.45115458
72HTLV-I infection_Homo sapiens_hsa051660.40197436
73Retinol metabolism_Homo sapiens_hsa008300.40029297
74Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.39523236
75NOD-like receptor signaling pathway_Homo sapiens_hsa046210.37343378
76Epstein-Barr virus infection_Homo sapiens_hsa051690.35423789
77Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.33884213
78Platelet activation_Homo sapiens_hsa046110.33489365
79Endocytosis_Homo sapiens_hsa041440.32001945
80Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.31736415
81Arachidonic acid metabolism_Homo sapiens_hsa005900.30198678
82Jak-STAT signaling pathway_Homo sapiens_hsa046300.30071370
83Taste transduction_Homo sapiens_hsa047420.29782264
84Chemokine signaling pathway_Homo sapiens_hsa040620.28816949
85Tuberculosis_Homo sapiens_hsa051520.27870819
86Pertussis_Homo sapiens_hsa051330.27754894
87Influenza A_Homo sapiens_hsa051640.26712803
88Metabolic pathways_Homo sapiens_hsa011000.26319575
89Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.25850308
90Maturity onset diabetes of the young_Homo sapiens_hsa049500.23612190
91Fat digestion and absorption_Homo sapiens_hsa049750.23496741
92Glycerophospholipid metabolism_Homo sapiens_hsa005640.23405744
93Sulfur relay system_Homo sapiens_hsa041220.23073114
94Butanoate metabolism_Homo sapiens_hsa006500.23019100
95African trypanosomiasis_Homo sapiens_hsa051430.22275265
96Regulation of actin cytoskeleton_Homo sapiens_hsa048100.21781103
97Apoptosis_Homo sapiens_hsa042100.20132713
98Legionellosis_Homo sapiens_hsa051340.19494531
99Alcoholism_Homo sapiens_hsa050340.18334554
100Drug metabolism - other enzymes_Homo sapiens_hsa009830.17372442

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