TRBJ2-2P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Arp2/3 complex-mediated actin nucleation (GO:0034314)7.33649250
2actin nucleation (GO:0045010)6.26912514
3DNA deamination (GO:0045006)6.07300557
4cytidine metabolic process (GO:0046087)5.76171527
5cytidine catabolic process (GO:0006216)5.76171527
6cytidine deamination (GO:0009972)5.76171527
7regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.71870031
8purine deoxyribonucleotide catabolic process (GO:0009155)5.65952065
9positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.65104536
10positive thymic T cell selection (GO:0045059)5.44289507
11negative T cell selection (GO:0043383)5.40074544
12pyrimidine ribonucleoside catabolic process (GO:0046133)5.14570170
13negative thymic T cell selection (GO:0045060)5.01497232
14positive regulation of B cell differentiation (GO:0045579)4.99801089
15positive T cell selection (GO:0043368)4.91401001
16deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.86924979
17deoxyribonucleotide catabolic process (GO:0009264)4.54965145
18negative regulation of B cell apoptotic process (GO:0002903)4.52479754
19positive regulation of gamma-delta T cell activation (GO:0046645)4.42767737
20negative regulation of T cell apoptotic process (GO:0070233)4.36418555
21deoxyribose phosphate catabolic process (GO:0046386)4.32347026
22thymic T cell selection (GO:0045061)4.31175055
23regulation of B cell receptor signaling pathway (GO:0050855)4.17790882
24regulation of gamma-delta T cell differentiation (GO:0045586)4.12316854
25sequestering of actin monomers (GO:0042989)4.09699166
26antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.08942137
27antigen processing and presentation of endogenous antigen (GO:0019883)4.05677003
28positive regulation of natural killer cell mediated immunity (GO:0002717)4.05076356
29positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.02144797
30positive regulation of calcium-mediated signaling (GO:0050850)3.94325611
31positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.92819331
32pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.92036173
33NIK/NF-kappaB signaling (GO:0038061)3.90369954
34T cell selection (GO:0045058)3.89033371
35purine deoxyribonucleotide metabolic process (GO:0009151)3.88094787
36immunoglobulin mediated immune response (GO:0016064)3.87606063
37negative regulation of lymphocyte apoptotic process (GO:0070229)3.87401303
38positive regulation of alpha-beta T cell proliferation (GO:0046641)3.83691272
39regulation of B cell differentiation (GO:0045577)3.69998844
40T cell migration (GO:0072678)3.66864309
41regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.61873591
42regulation of natural killer cell mediated immunity (GO:0002715)3.61873591
43regulation of alpha-beta T cell proliferation (GO:0046640)3.55399451
44response to interferon-beta (GO:0035456)3.53764234
45mucosal-associated lymphoid tissue development (GO:0048537)3.53076629
46Peyers patch development (GO:0048541)3.53076629
47deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.49048246
48ribosomal small subunit assembly (GO:0000028)3.47599679
49positive regulation of lamellipodium assembly (GO:0010592)3.46905202
50pyrimidine nucleoside catabolic process (GO:0046135)3.45635963
512-deoxyribonucleotide metabolic process (GO:0009394)3.45390724
52pyrimidine nucleotide catabolic process (GO:0006244)3.44049705
53positive regulation of interleukin-4 production (GO:0032753)3.31801383
54B cell receptor signaling pathway (GO:0050853)3.30914549
55purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)3.30397194
56regulation of gamma-delta T cell activation (GO:0046643)3.29854634
57T cell receptor signaling pathway (GO:0050852)3.28409770
58regulation of T cell tolerance induction (GO:0002664)3.26738840
59regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.25575210
60antigen receptor-mediated signaling pathway (GO:0050851)3.25288493
61regulation of T cell receptor signaling pathway (GO:0050856)3.23852613
62antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.22894583
63mature B cell differentiation involved in immune response (GO:0002313)3.22859143
64deoxyribose phosphate metabolic process (GO:0019692)3.22615049
65T cell costimulation (GO:0031295)3.21559380
66leukocyte aggregation (GO:0070486)3.20822246
67lymphocyte costimulation (GO:0031294)3.17581884
68B cell mediated immunity (GO:0019724)3.15416366
69positive regulation of tolerance induction (GO:0002645)3.14596521
70positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.14512288
71RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.12951287
72tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.12951287
73negative regulation of stress fiber assembly (GO:0051497)3.11757102
74regulation of T cell apoptotic process (GO:0070232)3.09869823
75regulation of interleukin-2 biosynthetic process (GO:0045076)3.09352975
76cellular response to interferon-beta (GO:0035458)3.08679490
77purine nucleotide salvage (GO:0032261)3.07781058
78regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.06089744
79mast cell activation (GO:0045576)3.05981117
80negative regulation of thymocyte apoptotic process (GO:0070244)3.04639931
81negative regulation of viral genome replication (GO:0045071)3.03357091
82respiratory burst (GO:0045730)3.02807986
83nucleotide salvage (GO:0043173)3.02649564
84negative regulation of nitric-oxide synthase activity (GO:0051001)3.02237546
85antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.00118436
86mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.99192641
87response to pheromone (GO:0019236)2.95339277
88mast cell degranulation (GO:0043303)2.94822093
89mast cell activation involved in immune response (GO:0002279)2.94822093
90regulation of interleukin-4 production (GO:0032673)2.94804797
91pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.92831877
92negative regulation of leukocyte apoptotic process (GO:2000107)2.92194086
93antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.90611115
94positive regulation of T cell differentiation in thymus (GO:0033089)2.88227255
95regulation of germinal center formation (GO:0002634)2.87620329
96regulation of lymphocyte apoptotic process (GO:0070228)2.86288905
97regulation of B cell apoptotic process (GO:0002902)2.83387551
98positive regulation of cell killing (GO:0031343)2.82955789
99antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.81949393
100regulation of activation of Janus kinase activity (GO:0010533)2.81431159

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.39488955
2BP1_19119308_ChIP-ChIP_Hs578T_Human3.98137399
3ELF1_17652178_ChIP-ChIP_JURKAT_Human3.93757225
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.85904193
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.51519146
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.51108905
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.19047838
8IRF8_21731497_ChIP-ChIP_J774_Mouse3.04897344
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.04381668
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.01843811
11SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.95075003
12MYB_26560356_Chip-Seq_TH2_Human2.80209250
13SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.76778690
14RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.70299734
15UTX_26944678_Chip-Seq_JUKART_Human2.60443885
16FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.39671701
17FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.34856253
18RUNX_20019798_ChIP-Seq_JUKART_Human2.19147471
19LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.17713637
20MYB_26560356_Chip-Seq_TH1_Human2.10803017
21CIITA_25753668_ChIP-Seq_RAJI_Human2.06038348
22MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.99612574
23SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.98807179
24BCL6_27268052_Chip-Seq_Bcells_Human1.97690187
25GATA3_27048872_Chip-Seq_THYMUS_Human1.97390952
26STAT4_19710469_ChIP-ChIP_TH1__Mouse1.97211973
27MAF_26560356_Chip-Seq_TH1_Human1.89393274
28SPI1_23547873_ChIP-Seq_NB4_Human1.89000416
29JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.85280147
30E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.83715847
31EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.78808640
32VDR_23849224_ChIP-Seq_CD4+_Human1.75540489
33MAF_26560356_Chip-Seq_TH2_Human1.73632267
34MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.73120841
35TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.71693604
36LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.66873963
37EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.54279494
38GABP_17652178_ChIP-ChIP_JURKAT_Human1.53366271
39SRF_21415370_ChIP-Seq_HL-1_Mouse1.50961078
40BCOR_27268052_Chip-Seq_Bcells_Human1.50305602
41GATA3_26560356_Chip-Seq_TH2_Human1.49651916
42RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.47770114
43CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.46576092
44GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.46408727
45ELF1_20517297_ChIP-Seq_JURKAT_Human1.45644706
46PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.42313182
47VDR_24763502_ChIP-Seq_THP-1_Human1.40518353
48YY1_21170310_ChIP-Seq_MESCs_Mouse1.39236960
49FOXP3_21729870_ChIP-Seq_TREG_Human1.39070707
50VDR_21846776_ChIP-Seq_THP-1_Human1.38536856
51SCL_19346495_ChIP-Seq_HPC-7_Human1.38308181
52P300_27268052_Chip-Seq_Bcells_Human1.36921828
53FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.35443764
54EST1_17652178_ChIP-ChIP_JURKAT_Human1.34496233
55ETS1_20019798_ChIP-Seq_JURKAT_Human1.34141019
56STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.33421055
57MYC_22102868_ChIP-Seq_BL_Human1.28653791
58SPI1_20517297_ChIP-Seq_HL60_Human1.28312063
59E2F7_22180533_ChIP-Seq_HELA_Human1.23888187
60VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.21040445
61NANOG_20526341_ChIP-Seq_ESCs_Human1.18548596
62KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.18065674
63RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.17302923
64HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.16128138
65FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12774867
66YY1_22570637_ChIP-Seq_MALME-3M_Human1.12487138
67CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.11407710
68SPI1_23127762_ChIP-Seq_K562_Human1.09618048
69MYC_18358816_ChIP-ChIP_MESCs_Mouse1.09329584
70CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.09269644
71HOXB4_20404135_ChIP-ChIP_EML_Mouse1.08621960
72E2F1_20622854_ChIP-Seq_HELA_Human1.07483526
73CTCF_26484167_Chip-Seq_Bcells_Mouse1.07335340
74P68_20966046_ChIP-Seq_HELA_Human1.06953960
75E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.04156585
76CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.03822883
77RUNX1_22412390_ChIP-Seq_EML_Mouse1.03242989
78PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.01853113
79PHF8_20622854_ChIP-Seq_HELA_Human1.00474798
80SA1_27219007_Chip-Seq_Bcells_Human0.99950694
81IRF8_27001747_Chip-Seq_BMDM_Mouse0.99889806
82CTCF_20526341_ChIP-Seq_ESCs_Human0.99703675
83CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.99423725
84PU.1_20513432_ChIP-Seq_Bcells_Mouse0.97211535
85SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.96098974
86TAF2_19829295_ChIP-Seq_ESCs_Human0.95916975
87AR_20517297_ChIP-Seq_VCAP_Human0.95100903
88GATA2_22383799_ChIP-Seq_G1ME_Mouse0.94800659
89PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.93787290
90TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92976892
91SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.92055078
92ERA_21632823_ChIP-Seq_H3396_Human0.91105336
93CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.88039766
94TET1_21451524_ChIP-Seq_MESCs_Mouse0.87917818
95ETS1_21867929_ChIP-Seq_TH2_Mouse0.87772941
96TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.86655429
97IGF1R_20145208_ChIP-Seq_DFB_Human0.86034319
98SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.85152950
99RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.84478709
100HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.84337390

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to5.45836864
2MP0001835_abnormal_antigen_presentation3.75920227
3MP0003763_abnormal_thymus_physiology3.30330986
4MP0009785_altered_susceptibility_to3.23325799
5MP0001800_abnormal_humoral_immune3.02850979
6MP0002638_abnormal_pupillary_reflex2.80311124
7MP0005000_abnormal_immune_tolerance2.78177686
8MP0005025_abnormal_response_to2.77508781
9MP0002420_abnormal_adaptive_immunity2.77199929
10MP0001819_abnormal_immune_cell2.70019926
11MP0005387_immune_system_phenotype2.67919122
12MP0001790_abnormal_immune_system2.67919122
13MP0002723_abnormal_immune_serum2.62350919
14MP0002166_altered_tumor_susceptibility2.60848171
15MP0009333_abnormal_splenocyte_physiolog2.58547810
16MP0002148_abnormal_hypersensitivity_rea2.53761772
17MP0005645_abnormal_hypothalamus_physiol2.52090316
18MP0002452_abnormal_antigen_presenting2.46949242
19MP0005075_abnormal_melanosome_morpholog2.31163751
20MP0002398_abnormal_bone_marrow2.31099223
21MP0003191_abnormal_cellular_cholesterol2.17985977
22MP0000716_abnormal_immune_system2.17918830
23MP0000685_abnormal_immune_system2.17773097
24MP0000689_abnormal_spleen_morphology1.94759669
25MP0002419_abnormal_innate_immunity1.94677958
26MP0002006_tumorigenesis1.93832746
27MP0002722_abnormal_immune_system1.85403851
28MP0002405_respiratory_system_inflammati1.84839663
29MP0001905_abnormal_dopamine_level1.83088139
30MP0003436_decreased_susceptibility_to1.80564023
31MP0003646_muscle_fatigue1.78286210
32MP0010155_abnormal_intestine_physiology1.75257993
33MP0000372_irregular_coat_pigmentation1.73494247
34MP0002429_abnormal_blood_cell1.72624898
35MP0000703_abnormal_thymus_morphology1.68093296
36MP0003806_abnormal_nucleotide_metabolis1.67297397
37MP0003866_abnormal_defecation1.66389765
38MP0001764_abnormal_homeostasis1.60704579
39MP0009697_abnormal_copulation1.58007076
40MP0001845_abnormal_inflammatory_respons1.49972815
41MP0005464_abnormal_platelet_physiology1.42890239
42MP0001873_stomach_inflammation1.39972501
43MP0003724_increased_susceptibility_to1.39496999
44MP0008469_abnormal_protein_level1.34681241
45MP0001853_heart_inflammation1.28688575
46MP0002933_joint_inflammation1.24235332
47MP0002138_abnormal_hepatobiliary_system1.20964704
48MP0009764_decreased_sensitivity_to1.19261007
49MP0004381_abnormal_hair_follicle1.18799547
50MP0008875_abnormal_xenobiotic_pharmacok1.18735348
51MP0005166_decreased_susceptibility_to1.16648140
52MP0003011_delayed_dark_adaptation1.15400469
53MP0008872_abnormal_physiological_respon1.14441954
54MP0003252_abnormal_bile_duct1.10750982
55MP0004145_abnormal_muscle_electrophysio1.10226830
56MP0002019_abnormal_tumor_incidence1.08614936
57MP0003448_altered_tumor_morphology1.07287773
58MP0005410_abnormal_fertilization1.03609427
59MP0003075_altered_response_to0.95868567
60MP0008877_abnormal_DNA_methylation0.94155256
61MP0000858_altered_metastatic_potential0.92890564
62MP0001968_abnormal_touch/_nociception0.92016113
63MP0002095_abnormal_skin_pigmentation0.90135919
64MP0000465_gastrointestinal_hemorrhage0.89749279
65MP0009763_increased_sensitivity_to0.88793088
66MP0006082_CNS_inflammation0.86751174
67MP0001533_abnormal_skeleton_physiology0.86611370
68MP0001986_abnormal_taste_sensitivity0.86468088
69MP0002277_abnormal_respiratory_mucosa0.85293152
70MP0005646_abnormal_pituitary_gland0.83534577
71MP0002396_abnormal_hematopoietic_system0.82508937
72MP0009379_abnormal_foot_pigmentation0.77378805
73MP0009643_abnormal_urine_homeostasis0.76327003
74MP0006036_abnormal_mitochondrial_physio0.74444806
75MP0004947_skin_inflammation0.73902029
76MP0002693_abnormal_pancreas_physiology0.73315435
77MP0005376_homeostasis/metabolism_phenot0.72544325
78MP0009278_abnormal_bone_marrow0.71631067
79MP0004147_increased_porphyrin_level0.69073450
80MP0005266_abnormal_metabolism0.67501255
81MP0008873_increased_physiological_sensi0.64161606
82MP0005084_abnormal_gallbladder_morpholo0.64030610
83MP0003183_abnormal_peptide_metabolism0.63808555
84MP0003878_abnormal_ear_physiology0.63772832
85MP0005377_hearing/vestibular/ear_phenot0.63772832
86MP0003786_premature_aging0.62256279
87MP0003137_abnormal_impulse_conducting0.61773074
88MP0002009_preneoplasia0.60807510
89MP0005253_abnormal_eye_physiology0.60512639
90MP0005551_abnormal_eye_electrophysiolog0.59679634
91MP0000639_abnormal_adrenal_gland0.59338644
92MP0001542_abnormal_bone_strength0.56990688
93MP0005330_cardiomyopathy0.56891582
94MP0001545_abnormal_hematopoietic_system0.56029369
95MP0005397_hematopoietic_system_phenotyp0.56029369
96MP0002822_catalepsy0.53598946
97MP0001663_abnormal_digestive_system0.53544611
98MP0005319_abnormal_enzyme/_coenzyme0.52911679
99MP0000604_amyloidosis0.52592167
100MP0005584_abnormal_enzyme/coenzyme_acti0.51887238

Predicted human phenotypes

RankGene SetZ-score
1Agammaglobulinemia (HP:0004432)7.23079231
2Aplastic anemia (HP:0001915)5.94125098
3Severe combined immunodeficiency (HP:0004430)5.91937256
4Combined immunodeficiency (HP:0005387)4.75640606
5Abnormality of B cell number (HP:0010975)4.74123077
6Elevated erythrocyte sedimentation rate (HP:0003565)4.72892600
7Autoimmune hemolytic anemia (HP:0001890)4.45665230
8B lymphocytopenia (HP:0010976)4.42875911
9IgG deficiency (HP:0004315)4.13514918
10Increased IgM level (HP:0003496)4.11401428
11T lymphocytopenia (HP:0005403)4.01839457
12Thyroiditis (HP:0100646)3.89983129
13Meningitis (HP:0001287)3.88566292
14Abnormality of T cell number (HP:0011839)3.77534566
15Recurrent bronchitis (HP:0002837)3.52378360
16Autoimmune thrombocytopenia (HP:0001973)3.49711174
17Panhypogammaglobulinemia (HP:0003139)3.45610845
18Hypoproteinemia (HP:0003075)3.31586641
19Abnormality of T cells (HP:0002843)3.29487693
20Increased IgE level (HP:0003212)3.25795534
21Cerebral palsy (HP:0100021)3.25690374
22Abnormality of eosinophils (HP:0001879)3.25263734
23Recurrent fungal infections (HP:0002841)3.22551535
24Mitochondrial inheritance (HP:0001427)3.20364703
25Cellulitis (HP:0100658)3.18642924
26Encephalitis (HP:0002383)3.15450793
27Hypergammaglobulinemia (HP:0010702)3.13856197
28Granulocytopenia (HP:0001913)3.13552066
29Eosinophilia (HP:0001880)3.08784981
30Recurrent viral infections (HP:0004429)3.05967669
31Sepsis (HP:0100806)2.97002768
32Mesangial abnormality (HP:0001966)2.96562075
33Chronic sinusitis (HP:0011109)2.96500662
34Recurrent pneumonia (HP:0006532)2.93639901
35Abnormal mitochondria in muscle tissue (HP:0008316)2.92570413
36Acute necrotizing encephalopathy (HP:0006965)2.90120004
37Chronic obstructive pulmonary disease (HP:0006510)2.85876184
38Obstructive lung disease (HP:0006536)2.85876184
39Eczematoid dermatitis (HP:0000976)2.82629810
40Verrucae (HP:0200043)2.81339863
41Papilloma (HP:0012740)2.81339863
42Recurrent cutaneous fungal infections (HP:0011370)2.71570694
43Chronic mucocutaneous candidiasis (HP:0002728)2.71570694
44Pancytopenia (HP:0001876)2.71438200
45Lymphopenia (HP:0001888)2.70008160
46Leukocytosis (HP:0001974)2.67014283
47Abnormality of the prostate (HP:0008775)2.66983111
48Hepatocellular necrosis (HP:0001404)2.66236902
49Abnormal delayed hypersensitivity skin test (HP:0002963)2.65562988
50Recurrent gram-negative bacterial infections (HP:0005420)2.61180072
51Oral leukoplakia (HP:0002745)2.56619551
52Increased intramyocellular lipid droplets (HP:0012240)2.55299099
53Skin rash (HP:0000988)2.52431700
54Type I transferrin isoform profile (HP:0003642)2.48760818
55Abnormality of cells of the lymphoid lineage (HP:0012140)2.46615313
563-Methylglutaconic aciduria (HP:0003535)2.46188102
57Amyotrophic lateral sclerosis (HP:0007354)2.45061521
58Increased CSF lactate (HP:0002490)2.44821792
59Chronic diarrhea (HP:0002028)2.44549909
60Lymphoma (HP:0002665)2.42839173
61Absent rod-and cone-mediated responses on ERG (HP:0007688)2.42514230
62Abnormality of macrophages (HP:0004311)2.42326838
63Hypoplasia of the thymus (HP:0000778)2.41969013
64Recurrent lower respiratory tract infections (HP:0002783)2.41943276
65Stomatitis (HP:0010280)2.41494022
66Acute hepatic failure (HP:0006554)2.40957686
67IgM deficiency (HP:0002850)2.40496195
68Progressive macrocephaly (HP:0004481)2.36289260
69Abnormality of T cell physiology (HP:0011840)2.35081936
70Increased muscle lipid content (HP:0009058)2.33513654
71Prostate neoplasm (HP:0100787)2.33372506
72Hepatic necrosis (HP:0002605)2.32787506
73Petechiae (HP:0000967)2.29546047
74Acute encephalopathy (HP:0006846)2.24159061
75Bronchitis (HP:0012387)2.23327556
76Congenital stationary night blindness (HP:0007642)2.20412144
77Mediastinal lymphadenopathy (HP:0100721)2.19751465
78Recurrent bacterial skin infections (HP:0005406)2.19308725
79Aplasia/Hypoplasia of the thymus (HP:0010515)2.19205867
80Myositis (HP:0100614)2.15895873
81Cerebral edema (HP:0002181)2.15870016
82Osteomyelitis (HP:0002754)2.06700155
83Increased hepatocellular lipid droplets (HP:0006565)2.03198467
84Pustule (HP:0200039)2.01075852
85Recurrent otitis media (HP:0000403)2.00874247
86Thrombocytosis (HP:0001894)2.00183530
87Renal Fanconi syndrome (HP:0001994)1.99505666
88Recurrent abscess formation (HP:0002722)1.98684881
89Decreased central vision (HP:0007663)1.97664176
90Inflammation of the large intestine (HP:0002037)1.97408739
91Dicarboxylic aciduria (HP:0003215)1.94440092
92Abnormality of dicarboxylic acid metabolism (HP:0010995)1.94440092
93Cellular immunodeficiency (HP:0005374)1.92755787
94Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.92695653
95Abnormal protein N-linked glycosylation (HP:0012347)1.92695653
96Abnormal protein glycosylation (HP:0012346)1.92695653
97Abnormal glycosylation (HP:0012345)1.92695653
98Recurrent skin infections (HP:0001581)1.92197347
99Abnormal rod and cone electroretinograms (HP:0008323)1.89010702
100Decreased electroretinogram (ERG) amplitude (HP:0000654)1.87557978

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK27.18466422
2KDR6.59267617
3SCYL23.79286087
4TESK13.37227682
5TXK3.36588093
6VRK23.08658613
7MAP3K112.60031020
8IKBKE2.43496129
9LIMK12.29559740
10MAP4K12.22528476
11MUSK1.98330017
12TAOK31.87841724
13BCKDK1.83363715
14MAP4K21.71432316
15MAP3K121.66536756
16PASK1.62140379
17KIT1.61350065
18ZAP701.59629470
19ITK1.55642483
20SYK1.52450402
21TBK11.45058601
22STK161.44829960
23FES1.35330756
24PIM21.25512943
25BTK1.23862322
26LCK1.23662180
27ERN11.15811416
28VRK11.10793429
29GRK61.09932224
30TNK21.09137892
31LYN1.08168241
32TEC1.08063037
33NME21.05109763
34PRKCQ0.98504554
35NUAK10.94031986
36BLK0.91594627
37MAPK130.91572935
38JAK30.90749387
39BMPR20.90645057
40ADRBK20.89028111
41CSF1R0.87261423
42MARK30.86661453
43ARAF0.85416066
44GRK70.84066161
45TYK20.83784554
46IRAK40.80780020
47IKBKB0.77651432
48TAF10.75934833
49PIM10.73734000
50ZAK0.67942053
51DAPK10.67093867
52CSK0.62386857
53TIE10.57092219
54LRRK20.55521402
55RIPK40.53649096
56GRK10.53601220
57FYN0.52968925
58MYLK0.50900774
59HCK0.50528293
60STK100.45344459
61CLK10.45304192
62PIK3CG0.45216815
63CDK80.41607743
64SIK20.41548111
65MAP3K50.40591534
66INSRR0.39999713
67NLK0.39679661
68AURKA0.39494211
69RPS6KA50.39051244
70MAPK110.38047437
71SIK30.36105446
72PIK3CA0.34375216
73MAPKAPK30.32918933
74MAPKAPK50.30365055
75GRK50.30210519
76ATR0.30170212
77ADRBK10.28486684
78TAOK20.28048890
79OBSCN0.26526169
80CAMKK10.26451965
81TLK10.25751170
82IGF1R0.24311219
83CDK190.23715246
84PRKCH0.23564195
85PRKCA0.23544583
86MAPKAPK20.23330475
87ROCK10.22893541
88PRKCI0.22817675
89MAP3K30.22794901
90PAK10.22698335
91MAPK150.21962690
92MAP2K60.21600527
93INSR0.21155918
94CSNK2A20.20873853
95MST40.20819113
96PRKD10.20742694
97FLT30.19750947
98CSNK2A10.19732341
99MAPK120.15109434
100PKN10.15100558

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053407.11029408
2Proteasome_Homo sapiens_hsa030503.82268795
3Graft-versus-host disease_Homo sapiens_hsa053323.03576988
4Allograft rejection_Homo sapiens_hsa053302.92382840
5Autoimmune thyroid disease_Homo sapiens_hsa053202.89245048
6Antigen processing and presentation_Homo sapiens_hsa046122.86480796
7Hematopoietic cell lineage_Homo sapiens_hsa046402.62720203
8Oxidative phosphorylation_Homo sapiens_hsa001902.56509972
9Parkinsons disease_Homo sapiens_hsa050122.49302394
10Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.39969833
11Intestinal immune network for IgA production_Homo sapiens_hsa046722.27015450
12Type I diabetes mellitus_Homo sapiens_hsa049402.22761598
13Ribosome_Homo sapiens_hsa030102.13865820
14Asthma_Homo sapiens_hsa053102.00172921
15Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.94859401
16T cell receptor signaling pathway_Homo sapiens_hsa046601.77877449
17Viral myocarditis_Homo sapiens_hsa054161.56694144
18Phototransduction_Homo sapiens_hsa047441.49988379
19Base excision repair_Homo sapiens_hsa034101.48702037
20RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.46302579
21Homologous recombination_Homo sapiens_hsa034401.43332577
22Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.41582237
23Measles_Homo sapiens_hsa051621.39979997
24Alzheimers disease_Homo sapiens_hsa050101.38685082
25Huntingtons disease_Homo sapiens_hsa050161.35599500
26Shigellosis_Homo sapiens_hsa051311.33745323
27DNA replication_Homo sapiens_hsa030301.31625839
28Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.29185720
29NF-kappa B signaling pathway_Homo sapiens_hsa040641.24560289
30Malaria_Homo sapiens_hsa051441.22820085
31Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.21982496
32Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.19310985
33RNA polymerase_Homo sapiens_hsa030201.18419852
34Staphylococcus aureus infection_Homo sapiens_hsa051501.13169934
35Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.08213133
36Herpes simplex infection_Homo sapiens_hsa051681.07241981
37Rheumatoid arthritis_Homo sapiens_hsa053231.06763797
38Caffeine metabolism_Homo sapiens_hsa002321.06564679
39Leishmaniasis_Homo sapiens_hsa051401.05479196
40SNARE interactions in vesicular transport_Homo sapiens_hsa041300.98596606
41Pyrimidine metabolism_Homo sapiens_hsa002400.97358985
42Cardiac muscle contraction_Homo sapiens_hsa042600.91348320
43Salmonella infection_Homo sapiens_hsa051320.90516136
44B cell receptor signaling pathway_Homo sapiens_hsa046620.89246671
45Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.86843429
46Peroxisome_Homo sapiens_hsa041460.85319862
47Non-homologous end-joining_Homo sapiens_hsa034500.81924506
48Systemic lupus erythematosus_Homo sapiens_hsa053220.81866761
49Fanconi anemia pathway_Homo sapiens_hsa034600.80261936
50Olfactory transduction_Homo sapiens_hsa047400.75257110
51alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.73079373
52Mismatch repair_Homo sapiens_hsa034300.70305134
53Purine metabolism_Homo sapiens_hsa002300.66078688
54Linoleic acid metabolism_Homo sapiens_hsa005910.62947845
55Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.62738867
56Drug metabolism - other enzymes_Homo sapiens_hsa009830.61817433
57Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.60535672
58Nucleotide excision repair_Homo sapiens_hsa034200.59240967
59Pertussis_Homo sapiens_hsa051330.57280195
60Steroid hormone biosynthesis_Homo sapiens_hsa001400.55298104
61Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.55073084
62Toll-like receptor signaling pathway_Homo sapiens_hsa046200.54659020
63Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.54518544
642-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.54188976
65Influenza A_Homo sapiens_hsa051640.47011545
66Retinol metabolism_Homo sapiens_hsa008300.46011321
67Osteoclast differentiation_Homo sapiens_hsa043800.45403986
68Platelet activation_Homo sapiens_hsa046110.44350665
69Epstein-Barr virus infection_Homo sapiens_hsa051690.43648505
70Tuberculosis_Homo sapiens_hsa051520.42531955
71Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.40117105
72NOD-like receptor signaling pathway_Homo sapiens_hsa046210.40066152
73Butanoate metabolism_Homo sapiens_hsa006500.38026892
74Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.37991935
75Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.37732028
76Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.36874555
77HTLV-I infection_Homo sapiens_hsa051660.36124124
78Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.34561646
79Taste transduction_Homo sapiens_hsa047420.31879207
80Regulation of autophagy_Homo sapiens_hsa041400.31069143
81Jak-STAT signaling pathway_Homo sapiens_hsa046300.30262856
82Chemokine signaling pathway_Homo sapiens_hsa040620.26830227
83Phagosome_Homo sapiens_hsa041450.25305423
84RNA degradation_Homo sapiens_hsa030180.25185437
85Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.24777630
86Metabolic pathways_Homo sapiens_hsa011000.24724728
87One carbon pool by folate_Homo sapiens_hsa006700.24280669
88Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.23934638
89Chemical carcinogenesis_Homo sapiens_hsa052040.22784027
90Glycosaminoglycan degradation_Homo sapiens_hsa005310.22356004
91Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.22036694
92Tyrosine metabolism_Homo sapiens_hsa003500.20977651
93Leukocyte transendothelial migration_Homo sapiens_hsa046700.20872898
94Spliceosome_Homo sapiens_hsa030400.20633545
95Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.20564242
96Fatty acid elongation_Homo sapiens_hsa000620.20440312
97Arachidonic acid metabolism_Homo sapiens_hsa005900.19986160
98Endocytosis_Homo sapiens_hsa041440.19715084
99Sulfur relay system_Homo sapiens_hsa041220.17318633
100Tryptophan metabolism_Homo sapiens_hsa003800.16456630

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