TRBJ2-6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of B cell receptor signaling pathway (GO:0050855)7.60926129
2positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)7.22223970
3positive T cell selection (GO:0043368)6.99659418
4negative T cell selection (GO:0043383)6.80987987
5positive thymic T cell selection (GO:0045059)6.26279127
6DNA deamination (GO:0045006)5.96063785
7cytidine metabolic process (GO:0046087)5.80690320
8cytidine catabolic process (GO:0006216)5.80690320
9cytidine deamination (GO:0009972)5.80690320
10regulation of B cell differentiation (GO:0045577)5.75406900
11negative thymic T cell selection (GO:0045060)5.48501312
12positive regulation of B cell differentiation (GO:0045579)5.47498692
13regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.32025063
14T cell selection (GO:0045058)5.22422523
15regulation of alpha-beta T cell proliferation (GO:0046640)5.16026283
16deoxyribonucleoside monophosphate metabolic process (GO:0009162)5.12853882
17regulation of antigen receptor-mediated signaling pathway (GO:0050854)5.09637085
18thymic T cell selection (GO:0045061)5.06324017
19pyrimidine ribonucleoside catabolic process (GO:0046133)4.96463678
20negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)4.69421129
21regulation of T cell receptor signaling pathway (GO:0050856)4.62209475
22leukocyte aggregation (GO:0070486)4.52467409
23mucosal-associated lymphoid tissue development (GO:0048537)4.44540945
24Peyers patch development (GO:0048541)4.44540945
25positive regulation of tolerance induction (GO:0002645)4.23830235
26positive regulation of gamma-delta T cell activation (GO:0046645)4.21904094
27positive regulation of macrophage differentiation (GO:0045651)4.20373822
28negative regulation of B cell apoptotic process (GO:0002903)4.19530921
29regulation of T cell tolerance induction (GO:0002664)4.17502284
30T cell migration (GO:0072678)4.16197836
31antigen receptor-mediated signaling pathway (GO:0050851)4.10489346
32positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.09531800
33T cell costimulation (GO:0031295)4.09336288
34negative regulation of T cell apoptotic process (GO:0070233)4.09213854
35lymphocyte costimulation (GO:0031294)4.04112059
36T cell receptor signaling pathway (GO:0050852)4.01775997
37negative regulation by host of viral transcription (GO:0043922)4.00499022
38positive regulation of calcium-mediated signaling (GO:0050850)4.00172375
39pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.97969343
40Arp2/3 complex-mediated actin nucleation (GO:0034314)3.79295269
41B cell receptor signaling pathway (GO:0050853)3.76343309
42purinergic nucleotide receptor signaling pathway (GO:0035590)3.75863041
43antigen processing and presentation of endogenous antigen (GO:0019883)3.75731159
44negative regulation of lymphocyte apoptotic process (GO:0070229)3.73555039
45negative regulation of T cell receptor signaling pathway (GO:0050860)3.67301726
46cellular response to interleukin-15 (GO:0071350)3.62483040
47positive regulation of lymphocyte migration (GO:2000403)3.62143140
48negative regulation of alpha-beta T cell activation (GO:0046636)3.61287516
49purine deoxyribonucleotide catabolic process (GO:0009155)3.60133777
50negative regulation of B cell proliferation (GO:0030889)3.57901367
51regulation of gamma-delta T cell differentiation (GO:0045586)3.57585740
52antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.57085147
53positive regulation of granulocyte differentiation (GO:0030854)3.54650392
54deoxyribonucleotide catabolic process (GO:0009264)3.54371344
55regulation of tolerance induction (GO:0002643)3.52036327
56G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.44932890
57deoxyribose phosphate catabolic process (GO:0046386)3.40660139
58regulation of lymphocyte chemotaxis (GO:1901623)3.40124282
59mature B cell differentiation (GO:0002335)3.37675012
60regulation of activation of Janus kinase activity (GO:0010533)3.35397151
61regulation of B cell apoptotic process (GO:0002902)3.31700474
62pyrimidine nucleoside catabolic process (GO:0046135)3.31103447
63negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.31097750
64negative regulation of cell killing (GO:0031342)3.31097750
65positive regulation of alpha-beta T cell proliferation (GO:0046641)3.30005889
66response to interleukin-15 (GO:0070672)3.28808827
67purine nucleotide salvage (GO:0032261)3.25265493
68pyrimidine nucleotide catabolic process (GO:0006244)3.24686516
69actin nucleation (GO:0045010)3.18390188
70negative regulation of B cell activation (GO:0050869)3.17572926
71regulation of calcium-mediated signaling (GO:0050848)3.15451955
72B cell mediated immunity (GO:0019724)3.15020655
73regulation of interleukin-2 biosynthetic process (GO:0045076)3.12949037
74positive regulation of defense response to virus by host (GO:0002230)3.11361992
75positive regulation of interleukin-2 production (GO:0032743)3.10232262
76regulation of isotype switching to IgG isotypes (GO:0048302)3.09060899
77regulation of alpha-beta T cell activation (GO:0046634)3.09054529
78regulation of lymphocyte apoptotic process (GO:0070228)3.08621190
79regulation of B cell activation (GO:0050864)3.07347977
80regulation of T cell apoptotic process (GO:0070232)3.06146188
81pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.05506527
82regulation of gamma-delta T cell activation (GO:0046643)3.02138161
83regulation of macrophage differentiation (GO:0045649)2.97897479
84immunoglobulin mediated immune response (GO:0016064)2.97134710
85cellular response to type I interferon (GO:0071357)2.95090136
86type I interferon signaling pathway (GO:0060337)2.95090136
87positive regulation of T cell differentiation in thymus (GO:0033089)2.94506908
88positive regulation of lamellipodium assembly (GO:0010592)2.91387719
89negative regulation of interleukin-12 production (GO:0032695)2.90469148
90response to type I interferon (GO:0034340)2.90356683
91negative regulation of leukocyte apoptotic process (GO:2000107)2.88710644
92regulation of lymphocyte migration (GO:2000401)2.88376086
93autophagic vacuole fusion (GO:0000046)2.85121234
94antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.85013752
95response to interferon-beta (GO:0035456)2.82217511
96regulation of B cell proliferation (GO:0030888)2.79806733
972-deoxyribonucleotide metabolic process (GO:0009394)2.78877159
98antigen processing and presentation via MHC class Ib (GO:0002475)2.75364774
99positive regulation of T cell activation (GO:0050870)2.74622800
100purine-containing compound salvage (GO:0043101)2.73767285

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human8.68209942
2IRF8_22096565_ChIP-ChIP_GC-B_Human5.79065493
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.71854190
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.59506469
5ELF1_17652178_ChIP-ChIP_JURKAT_Human3.28994654
6MYB_26560356_Chip-Seq_TH2_Human3.22020647
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.09990639
8RUNX_20019798_ChIP-Seq_JUKART_Human3.06249610
9SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.98356240
10SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.92762889
11MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.66018902
12RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.65720964
13UTX_26944678_Chip-Seq_JUKART_Human2.60618711
14IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.53003435
15LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.35113133
16SCL_19346495_ChIP-Seq_HPC-7_Human2.31074107
17MYB_26560356_Chip-Seq_TH1_Human2.20881706
18GATA3_27048872_Chip-Seq_THYMUS_Human2.15345601
19STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.14531044
20MAF_26560356_Chip-Seq_TH1_Human2.10979390
21FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.09329138
22MYC_22102868_ChIP-Seq_BL_Human2.07877297
23SPI1_23547873_ChIP-Seq_NB4_Human2.05582236
24SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.04876041
25E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.03448178
26STAT4_19710469_ChIP-ChIP_TH1__Mouse1.99235478
27MAF_26560356_Chip-Seq_TH2_Human1.98935926
28IRF8_21731497_ChIP-ChIP_J774_Mouse1.96933792
29FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.96213248
30VDR_21846776_ChIP-Seq_THP-1_Human1.93774329
31NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.91845134
32VDR_24763502_ChIP-Seq_THP-1_Human1.81785173
33MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.80672209
34TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.75214184
35GATA3_26560356_Chip-Seq_TH2_Human1.68484053
36LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.58954792
37RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.57624009
38SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.49927210
39ELF1_20517297_ChIP-Seq_JURKAT_Human1.49805921
40BCL6_27268052_Chip-Seq_Bcells_Human1.48448844
41HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.39330552
42ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.38572459
43CIITA_25753668_ChIP-Seq_RAJI_Human1.34149678
44FOXP3_21729870_ChIP-Seq_TREG_Human1.33847523
45RUNX1_22412390_ChIP-Seq_EML_Mouse1.33621687
46IRF8_27001747_Chip-Seq_BMDM_Mouse1.33224305
47STAT6_21828071_ChIP-Seq_BEAS2B_Human1.29551014
48VDR_23849224_ChIP-Seq_CD4+_Human1.29500358
49IGF1R_20145208_ChIP-Seq_DFB_Human1.25424544
50SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.21408890
51BRD4_27068464_Chip-Seq_AML-cells_Mouse1.20960935
52GATA2_22383799_ChIP-Seq_G1ME_Mouse1.17324425
53P300_27268052_Chip-Seq_Bcells_Human1.15045756
54SPI1_20517297_ChIP-Seq_HL60_Human1.12786421
55PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.12630922
56SPI1_23127762_ChIP-Seq_K562_Human1.12572823
57GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.09162601
58NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.08233510
59VDR_24787735_ChIP-Seq_THP-1_Human1.08182565
60MYB_21317192_ChIP-Seq_ERMYB_Mouse1.07760826
61CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.04956496
62FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04220090
63PU.1_20513432_ChIP-Seq_Bcells_Mouse1.04135938
64RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.03589739
65EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.03175251
66EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.02307144
67JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.01595659
68RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.00336865
69FLI1_27457419_Chip-Seq_LIVER_Mouse1.00132066
70PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99769108
71TCF7_22412390_ChIP-Seq_EML_Mouse0.99059077
72PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.98476518
73KDM2B_26808549_Chip-Seq_DND41_Human0.98425754
74VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.98354389
75GATA1_19941827_ChIP-Seq_MEL_Mouse0.96744751
76CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96713836
77KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.95961137
78TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95732617
79PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.95447542
80KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.95243354
81TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.94674875
82TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.94480266
83GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.92556513
84BCOR_27268052_Chip-Seq_Bcells_Human0.92354011
85NOTCH1_21737748_ChIP-Seq_TLL_Human0.91197840
86VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.90648701
87SMAD_19615063_ChIP-ChIP_OVARY_Human0.90541668
88GABP_17652178_ChIP-ChIP_JURKAT_Human0.90415712
89CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90382657
90HOXB4_20404135_ChIP-ChIP_EML_Mouse0.89212049
91TET1_21451524_ChIP-Seq_MESCs_Mouse0.86880026
92TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.85082631
93CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.84200417
94SRF_21415370_ChIP-Seq_HL-1_Mouse0.81460501
95CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.81240745
96SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.78963031
97RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.78500150
98YY1_22570637_ChIP-Seq_MALME-3M_Human0.78114928
99RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77426104
100CTCF_21964334_Chip-Seq_Bcells_Human0.77021886

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to5.04784289
2MP0003763_abnormal_thymus_physiology4.31882367
3MP0002009_preneoplasia4.15927054
4MP0001835_abnormal_antigen_presentation3.81244558
5MP0005000_abnormal_immune_tolerance3.27744282
6MP0002166_altered_tumor_susceptibility3.13491419
7MP0001800_abnormal_humoral_immune3.00130911
8MP0001873_stomach_inflammation2.76648435
9MP0002420_abnormal_adaptive_immunity2.70945629
10MP0005387_immune_system_phenotype2.64236122
11MP0001790_abnormal_immune_system2.64236122
12MP0001819_abnormal_immune_cell2.63568718
13MP0002723_abnormal_immune_serum2.59424359
14MP0002398_abnormal_bone_marrow2.53974723
15MP0005075_abnormal_melanosome_morpholog2.40539601
16MP0006082_CNS_inflammation2.37372479
17MP0009333_abnormal_splenocyte_physiolog2.36303395
18MP0002006_tumorigenesis2.35546258
19MP0002452_abnormal_antigen_presenting2.33506758
20MP0003436_decreased_susceptibility_to2.31623078
21MP0002148_abnormal_hypersensitivity_rea2.30586598
22MP0002933_joint_inflammation2.28381696
23MP0000716_abnormal_immune_system2.21285206
24MP0002405_respiratory_system_inflammati2.13594187
25MP0000703_abnormal_thymus_morphology2.09809731
26MP0005025_abnormal_response_to2.07730549
27MP0005451_abnormal_body_composition2.04565927
28MP0003724_increased_susceptibility_to1.96471300
29MP0009785_altered_susceptibility_to1.93576078
30MP0000689_abnormal_spleen_morphology1.89235055
31MP0002722_abnormal_immune_system1.84804331
32MP0002419_abnormal_innate_immunity1.76354574
33MP0002429_abnormal_blood_cell1.74701218
34MP0000465_gastrointestinal_hemorrhage1.70057714
35MP0005464_abnormal_platelet_physiology1.69695685
36MP0000372_irregular_coat_pigmentation1.65485324
37MP0000685_abnormal_immune_system1.57137033
38MP0009384_cardiac_valve_regurgitation1.49725776
39MP0010155_abnormal_intestine_physiology1.48180015
40MP0003300_gastrointestinal_ulcer1.47014927
41MP0001853_heart_inflammation1.35026051
42MP0002396_abnormal_hematopoietic_system1.34541498
43MP0003866_abnormal_defecation1.26158963
44MP0001845_abnormal_inflammatory_respons1.24985025
45MP0006292_abnormal_olfactory_placode1.24796700
46MP0009278_abnormal_bone_marrow1.22900786
47MP0006072_abnormal_retinal_apoptosis1.20203941
48MP0009697_abnormal_copulation1.20116697
49MP0003252_abnormal_bile_duct1.19769395
50MP0000858_altered_metastatic_potential1.12600519
51MP0008877_abnormal_DNA_methylation1.12142621
52MP0005397_hematopoietic_system_phenotyp1.10946493
53MP0001545_abnormal_hematopoietic_system1.10946493
54MP0002277_abnormal_respiratory_mucosa1.08830758
55MP0009764_decreased_sensitivity_to1.08062309
56MP0004381_abnormal_hair_follicle1.06634492
57MP0008469_abnormal_protein_level1.05914133
58MP0002138_abnormal_hepatobiliary_system1.05072784
59MP0004947_skin_inflammation1.05003795
60MP0002019_abnormal_tumor_incidence1.03349602
61MP0004142_abnormal_muscle_tone1.00077089
62MP0003646_muscle_fatigue0.99977972
63MP0003303_peritoneal_inflammation0.98628210
64MP0005310_abnormal_salivary_gland0.96837321
65MP0001984_abnormal_olfaction0.95964039
66MP0002928_abnormal_bile_duct0.85202669
67MP0009763_increased_sensitivity_to0.84460697
68MP0001533_abnormal_skeleton_physiology0.83778003
69MP0003448_altered_tumor_morphology0.82833087
70MP0003787_abnormal_imprinting0.82701245
71MP0002132_abnormal_respiratory_system0.81082002
72MP0000013_abnormal_adipose_tissue0.81073822
73MP0001764_abnormal_homeostasis0.80182043
74MP0005410_abnormal_fertilization0.78977062
75MP0005646_abnormal_pituitary_gland0.76335499
76MP0001663_abnormal_digestive_system0.75817967
77MP0008004_abnormal_stomach_pH0.75033575
78MP0001905_abnormal_dopamine_level0.74113188
79MP0008872_abnormal_physiological_respon0.71949996
80MP0008058_abnormal_DNA_repair0.71905355
81MP0008873_increased_physiological_sensi0.71460107
82MP0003638_abnormal_response/metabolism_0.70350355
83MP0001661_extended_life_span0.70304449
84MP0001881_abnormal_mammary_gland0.69449862
85MP0008961_abnormal_basal_metabolism0.64797993
86MP0001968_abnormal_touch/_nociception0.62539658
87MP0005645_abnormal_hypothalamus_physiol0.61116289
88MP0004185_abnormal_adipocyte_glucose0.59931316
89MP0009765_abnormal_xenobiotic_induced0.59291863
90MP0005253_abnormal_eye_physiology0.56902934
91MP0000230_abnormal_systemic_arterial0.56778069
92MP0002163_abnormal_gland_morphology0.55935807
93MP0005084_abnormal_gallbladder_morpholo0.55264332
94MP0003656_abnormal_erythrocyte_physiolo0.53584632
95MP0008569_lethality_at_weaning0.53455555
96MP0004147_increased_porphyrin_level0.52905247
97MP0003806_abnormal_nucleotide_metabolis0.52097027
98MP0002693_abnormal_pancreas_physiology0.51847982
99MP0000249_abnormal_blood_vessel0.49272809
100MP0005319_abnormal_enzyme/_coenzyme0.48113706

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)6.77832493
2Panhypogammaglobulinemia (HP:0003139)6.23204749
3Severe combined immunodeficiency (HP:0004430)6.00877975
4Aplastic anemia (HP:0001915)5.99422118
5Autoimmune hemolytic anemia (HP:0001890)5.74901848
6Agammaglobulinemia (HP:0004432)5.71194075
7Combined immunodeficiency (HP:0005387)4.82754404
8Recurrent viral infections (HP:0004429)4.46233178
9Recurrent fungal infections (HP:0002841)4.30521357
10T lymphocytopenia (HP:0005403)4.25710964
11B lymphocytopenia (HP:0010976)4.19922946
12Hypoproteinemia (HP:0003075)4.19646630
13Granulocytopenia (HP:0001913)4.18984749
14Autoimmune thrombocytopenia (HP:0001973)4.09240597
15Encephalitis (HP:0002383)3.99455649
16Abnormal delayed hypersensitivity skin test (HP:0002963)3.98690241
17Increased IgE level (HP:0003212)3.97222968
18Abnormality of T cell number (HP:0011839)3.95042792
19Abnormality of T cells (HP:0002843)3.93841131
20Eosinophilia (HP:0001880)3.92371670
21Abnormality of B cell number (HP:0010975)3.88108455
22Meningitis (HP:0001287)3.82901389
23Abnormality of eosinophils (HP:0001879)3.66393638
24Thyroiditis (HP:0100646)3.63189589
25Hypoplasia of the thymus (HP:0000778)3.52214995
26Lymphopenia (HP:0001888)3.51095237
27Increased IgM level (HP:0003496)3.44292576
28Eczematoid dermatitis (HP:0000976)3.42394847
29Hypergammaglobulinemia (HP:0010702)3.38908713
30Chronic mucocutaneous candidiasis (HP:0002728)3.32703204
31Recurrent cutaneous fungal infections (HP:0011370)3.32703204
32Myositis (HP:0100614)3.29194690
33Leukocytosis (HP:0001974)3.24982420
34IgG deficiency (HP:0004315)3.24911880
35Stomatitis (HP:0010280)3.22835892
36Abnormality of cells of the lymphoid lineage (HP:0012140)3.21095903
37IgM deficiency (HP:0002850)3.05681194
38Abnormality of T cell physiology (HP:0011840)3.00963274
39Obstructive lung disease (HP:0006536)2.96238487
40Chronic obstructive pulmonary disease (HP:0006510)2.96238487
41Neonatal respiratory distress (HP:0002643)2.92891580
42Fatigue (HP:0012378)2.82989158
43Inflammation of the large intestine (HP:0002037)2.79823541
44Mediastinal lymphadenopathy (HP:0100721)2.78175971
45Hemiplegia (HP:0002301)2.75609755
46Abnormality of the prostate (HP:0008775)2.74936759
47Gastrointestinal inflammation (HP:0004386)2.69845443
48Gastrointestinal infarctions (HP:0005244)2.69175563
49Lymphoma (HP:0002665)2.68800680
50Oral leukoplakia (HP:0002745)2.66568689
51Vasculitis (HP:0002633)2.64682872
52Sepsis (HP:0100806)2.34758092
53Neutropenia (HP:0001875)2.34323866
54Recurrent abscess formation (HP:0002722)2.33281282
55Abnormality of macrophages (HP:0004311)2.32714264
56Recurrent skin infections (HP:0001581)2.32239818
57Congenital stationary night blindness (HP:0007642)2.30483414
58Chronic diarrhea (HP:0002028)2.29594986
59Recurrent bacterial skin infections (HP:0005406)2.27495767
60Retrobulbar optic neuritis (HP:0100654)2.25963617
61Optic neuritis (HP:0100653)2.25963617
62Mesangial abnormality (HP:0001966)2.24728284
63Aplasia/Hypoplasia of the thymus (HP:0010515)2.18975454
64Prolonged bleeding time (HP:0003010)2.18925941
65Orchitis (HP:0100796)2.18307348
66Recurrent bronchitis (HP:0002837)2.17794159
67Recurrent lower respiratory tract infections (HP:0002783)2.15945466
68Chest pain (HP:0100749)2.14077245
69Amyotrophic lateral sclerosis (HP:0007354)2.08961844
70Cellulitis (HP:0100658)2.05389067
71Pustule (HP:0200039)1.99502722
72Pulmonary infiltrates (HP:0002113)1.98797481
73Opisthotonus (HP:0002179)1.97184781
74Pancytopenia (HP:0001876)1.96856080
75Verrucae (HP:0200043)1.95839969
76Papilloma (HP:0012740)1.95839969
77Skin rash (HP:0000988)1.95423902
78Colitis (HP:0002583)1.92517146
79Viral hepatitis (HP:0006562)1.87676238
80Gangrene (HP:0100758)1.87484367
81Abnormality of the heme biosynthetic pathway (HP:0010472)1.85839334
82Cellular immunodeficiency (HP:0005374)1.83765058
83Recurrent pneumonia (HP:0006532)1.78292647
84Epistaxis (HP:0000421)1.76886101
85Recurrent otitis media (HP:0000403)1.76449390
86Chronic sinusitis (HP:0011109)1.76050014
87Joint swelling (HP:0001386)1.75885171
88Abnormality of male internal genitalia (HP:0000022)1.74407261
89Erythema (HP:0010783)1.73843813
90Hypertensive crisis (HP:0100735)1.69241593
91Hemoptysis (HP:0002105)1.69006315
92Abnormality of the pleura (HP:0002103)1.67637456
93Petechiae (HP:0000967)1.64366950
94Decreased electroretinogram (ERG) amplitude (HP:0000654)1.63499572
95Abnormal rod and cone electroretinograms (HP:0008323)1.62569942
96Recurrent sinusitis (HP:0011108)1.62038017
97Abnormality of alanine metabolism (HP:0010916)1.59347624
98Hyperalaninemia (HP:0003348)1.59347624
99Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.59347624
100Spontaneous hematomas (HP:0007420)1.57907634

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.98575147
2KDR4.71592390
3TAOK33.88160904
4TESK23.57103735
5MAP3K113.31287929
6SCYL23.10312596
7TXK3.04238786
8ITK2.67642292
9BTK2.11493358
10KIT2.11241963
11TNK22.02110541
12RIPK41.95691259
13SYK1.93149371
14CDK191.75800525
15CSF1R1.69539344
16IRAK21.69076717
17FES1.62337378
18PRKCQ1.58630738
19BCKDK1.58574616
20NME21.58366346
21TEC1.58255371
22TBK11.55799015
23LCK1.51742402
24ZAP701.49234896
25CSK1.39965654
26JAK31.38690656
27GRK61.36451482
28LYN1.25941798
29IKBKE1.16767046
30CDK121.16070081
31TYK21.15680812
32PIM11.13230804
33HCK1.08028154
34BMPR21.07789771
35TAOK11.07449495
36MAP2K31.06619508
37PRKCH1.05938898
38CCNB11.05754486
39VRK21.05574163
40TESK11.04741419
41MARK31.04399907
42MAP4K21.02415823
43MAP3K31.01747997
44MAPKAPK30.92570667
45IRAK40.90652170
46CDK90.86972100
47IKBKB0.84322560
48TAOK20.79992524
49CDK40.70036907
50CDK80.69036740
51VRK10.67048053
52DYRK1B0.66817542
53MAPK110.65980180
54IRAK10.64962535
55GRK10.64699905
56ADRBK20.62556811
57FLT30.61925216
58ZAK0.61656955
59CDK30.57028615
60TRPM70.56857824
61FYN0.53926427
62PIM20.52732612
63MAP3K70.49707944
64CAMKK20.49162285
65BUB10.48985170
66CDC70.48783560
67MAPK120.48741915
68MATK0.47325695
69UHMK10.46800772
70AKT30.44866082
71MAP2K60.43910064
72PRKD20.43898221
73PASK0.43804275
74JAK10.43657100
75DAPK10.43300197
76LRRK20.43191492
77CDK60.42333330
78HIPK20.38212437
79TGFBR20.36625395
80INSR0.35959122
81NLK0.35885866
82AURKA0.35703504
83SIK20.35209974
84MAPK130.32274385
85NUAK10.31261483
86PIK3CG0.30225703
87IGF1R0.29311049
88ABL10.29037543
89PRKCA0.26004996
90BLK0.25994436
91MAPK30.25537942
92RPS6KA10.25532913
93PDK10.25255368
94MAPKAPK20.24421051
95PRKD10.24228161
96FGR0.23711400
97CAMKK10.23513793
98MAPK150.23324583
99INSRR0.21424744
100STK100.18719079

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053406.39377925
2Graft-versus-host disease_Homo sapiens_hsa053323.69898387
3Autoimmune thyroid disease_Homo sapiens_hsa053203.54669624
4Allograft rejection_Homo sapiens_hsa053303.52904761
5Antigen processing and presentation_Homo sapiens_hsa046122.91810431
6Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.69313877
7T cell receptor signaling pathway_Homo sapiens_hsa046602.67816158
8Hematopoietic cell lineage_Homo sapiens_hsa046402.63676183
9Type I diabetes mellitus_Homo sapiens_hsa049402.61819452
10Asthma_Homo sapiens_hsa053102.52768418
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.51805300
12Intestinal immune network for IgA production_Homo sapiens_hsa046722.21701598
13Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.19975347
14NF-kappa B signaling pathway_Homo sapiens_hsa040642.05452169
15Leishmaniasis_Homo sapiens_hsa051401.97059442
16SNARE interactions in vesicular transport_Homo sapiens_hsa041301.90293514
17Measles_Homo sapiens_hsa051621.80955169
18Viral myocarditis_Homo sapiens_hsa054161.73588219
19RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.68796780
20Staphylococcus aureus infection_Homo sapiens_hsa051501.63394040
21B cell receptor signaling pathway_Homo sapiens_hsa046621.58385575
22Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.51643497
23Rheumatoid arthritis_Homo sapiens_hsa053231.48302517
24Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.48025710
25Herpes simplex infection_Homo sapiens_hsa051681.44249855
26Toll-like receptor signaling pathway_Homo sapiens_hsa046201.37608377
27Osteoclast differentiation_Homo sapiens_hsa043801.34441656
28Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.28342487
29Salmonella infection_Homo sapiens_hsa051321.26515058
30Homologous recombination_Homo sapiens_hsa034401.25581972
31Ribosome_Homo sapiens_hsa030101.21376277
32Proteasome_Homo sapiens_hsa030501.18047281
33Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.08459044
34Nucleotide excision repair_Homo sapiens_hsa034201.08218361
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.00619303
36Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.95856498
37DNA replication_Homo sapiens_hsa030300.92902307
38Jak-STAT signaling pathway_Homo sapiens_hsa046300.91038139
39NOD-like receptor signaling pathway_Homo sapiens_hsa046210.82899342
40Systemic lupus erythematosus_Homo sapiens_hsa053220.81515505
41Shigellosis_Homo sapiens_hsa051310.79229622
42Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.77771476
43Malaria_Homo sapiens_hsa051440.73164089
44Toxoplasmosis_Homo sapiens_hsa051450.73015000
45Influenza A_Homo sapiens_hsa051640.70485978
46Transcriptional misregulation in cancer_Homo sapiens_hsa052020.70274028
47Tuberculosis_Homo sapiens_hsa051520.70220837
48Caffeine metabolism_Homo sapiens_hsa002320.66233808
49Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.65981662
50Phototransduction_Homo sapiens_hsa047440.65935783
51Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.65708876
52Peroxisome_Homo sapiens_hsa041460.62667747
53Platelet activation_Homo sapiens_hsa046110.61932086
54Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.57569337
55HTLV-I infection_Homo sapiens_hsa051660.57224510
56Basal transcription factors_Homo sapiens_hsa030220.54496923
57Parkinsons disease_Homo sapiens_hsa050120.53315583
58Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.51051999
59Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.50789192
60Chemokine signaling pathway_Homo sapiens_hsa040620.50440788
61Oxidative phosphorylation_Homo sapiens_hsa001900.50292828
62African trypanosomiasis_Homo sapiens_hsa051430.47205366
63Pertussis_Homo sapiens_hsa051330.47040961
64Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.46688545
65Base excision repair_Homo sapiens_hsa034100.46092509
66Olfactory transduction_Homo sapiens_hsa047400.45869170
67Apoptosis_Homo sapiens_hsa042100.45858739
68Chemical carcinogenesis_Homo sapiens_hsa052040.43903591
69Leukocyte transendothelial migration_Homo sapiens_hsa046700.43171624
70Pyrimidine metabolism_Homo sapiens_hsa002400.41344401
71Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.40999699
72Epstein-Barr virus infection_Homo sapiens_hsa051690.40432730
73Fanconi anemia pathway_Homo sapiens_hsa034600.40141461
74Hepatitis B_Homo sapiens_hsa051610.40067502
75Mismatch repair_Homo sapiens_hsa034300.39194802
76Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.37798005
77Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.37055729
78Retinol metabolism_Homo sapiens_hsa008300.36432673
79Endocytosis_Homo sapiens_hsa041440.36070060
80Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.34602001
81Spliceosome_Homo sapiens_hsa030400.33390343
82Legionellosis_Homo sapiens_hsa051340.31866687
83Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.31589378
84Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.29792585
85Regulation of autophagy_Homo sapiens_hsa041400.28774170
86Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.28074590
87Non-homologous end-joining_Homo sapiens_hsa034500.28069757
88Alzheimers disease_Homo sapiens_hsa050100.27869909
89p53 signaling pathway_Homo sapiens_hsa041150.27736409
90Phagosome_Homo sapiens_hsa041450.26286790
91TNF signaling pathway_Homo sapiens_hsa046680.20671736
92Drug metabolism - other enzymes_Homo sapiens_hsa009830.20429066
93Non-small cell lung cancer_Homo sapiens_hsa052230.20417910
94Viral carcinogenesis_Homo sapiens_hsa052030.20375464
95Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.17930969
96Maturity onset diabetes of the young_Homo sapiens_hsa049500.16207943
97Glycerophospholipid metabolism_Homo sapiens_hsa005640.14229895
98N-Glycan biosynthesis_Homo sapiens_hsa005100.13375627
99Propanoate metabolism_Homo sapiens_hsa006400.12481119
100Nitrogen metabolism_Homo sapiens_hsa009100.11309353

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