TRBV1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G8.82497226
2sequestering of actin monomers (GO:0042989)7.87670964
3cellular response to interleukin-15 (GO:0071350)7.68938772
4positive thymic T cell selection (GO:0045059)7.11917962
5positive regulation of gamma-delta T cell activation (GO:0046645)6.87248906
6negative thymic T cell selection (GO:0045060)6.73399759
7negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.71625134
8negative regulation of cell killing (GO:0031342)6.71625134
9response to interleukin-15 (GO:0070672)6.67082787
10negative T cell selection (GO:0043383)6.65229681
11leukocyte aggregation (GO:0070486)6.52710360
12positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)6.50431073
13thymic T cell selection (GO:0045061)6.40808792
14lymphocyte costimulation (GO:0031294)6.39215099
15T cell costimulation (GO:0031295)6.36466392
16positive T cell selection (GO:0043368)5.92544273
17regulation of gamma-delta T cell differentiation (GO:0045586)5.83360140
18T cell receptor signaling pathway (GO:0050852)5.76143009
19tolerance induction (GO:0002507)5.74376254
20positive regulation of interleukin-8 secretion (GO:2000484)5.59189210
21T cell selection (GO:0045058)5.52861445
22DNA deamination (GO:0045006)5.47145364
23regulation of gamma-delta T cell activation (GO:0046643)5.43613533
24regulation of isotype switching to IgG isotypes (GO:0048302)5.36780942
25antigen processing and presentation via MHC class Ib (GO:0002475)4.96509196
26antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.87300433
27antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.87300433
28regulation of T cell mediated cytotoxicity (GO:0001914)4.81571373
29antigen receptor-mediated signaling pathway (GO:0050851)4.77535364
30regulation of T cell receptor signaling pathway (GO:0050856)4.73150788
31regulation of T cell tolerance induction (GO:0002664)4.60466655
32regulation of leukocyte mediated cytotoxicity (GO:0001910)4.45822627
33regulation of respiratory burst (GO:0060263)4.36185275
34response to type I interferon (GO:0034340)4.36052691
35cellular response to type I interferon (GO:0071357)4.35346555
36type I interferon signaling pathway (GO:0060337)4.35346555
37natural killer cell activation (GO:0030101)4.31938869
38positive regulation of leukocyte mediated cytotoxicity (GO:0001912)4.29008249
39positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.27423703
40positive regulation of natural killer cell mediated immunity (GO:0002717)4.25371727
41positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)4.25371727
42regulation of natural killer cell mediated immunity (GO:0002715)4.13343700
43regulation of natural killer cell mediated cytotoxicity (GO:0042269)4.13343700
44regulation of antigen receptor-mediated signaling pathway (GO:0050854)4.13096410
45interferon-gamma production (GO:0032609)4.09749150
46positive regulation of type I interferon-mediated signaling pathway (GO:0060340)4.06784021
47antigen processing and presentation of endogenous antigen (GO:0019883)4.02689349
48positive regulation of lamellipodium assembly (GO:0010592)4.01969121
49positive regulation of T cell mediated cytotoxicity (GO:0001916)4.01509223
50regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.98911593
51regulation of response to interferon-gamma (GO:0060330)3.97620150
52T cell migration (GO:0072678)3.97616711
53positive regulation of macrophage differentiation (GO:0045651)3.92637424
54positive regulation of tolerance induction (GO:0002645)3.85576474
55cellular extravasation (GO:0045123)3.85031975
56mast cell activation (GO:0045576)3.83578791
57regulation of type I interferon-mediated signaling pathway (GO:0060338)3.79854775
58regulation of cell killing (GO:0031341)3.79811162
59regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.78641643
60regulation of defense response to virus by virus (GO:0050690)3.72678497
61regulation of hypersensitivity (GO:0002883)3.63791920
62positive regulation of cell killing (GO:0031343)3.63632527
63positive regulation of humoral immune response (GO:0002922)3.63049886
64interferon-gamma-mediated signaling pathway (GO:0060333)3.60820441
65regulation of B cell receptor signaling pathway (GO:0050855)3.59518414
66positive regulation of lamellipodium organization (GO:1902745)3.54294784
67regulation of immunoglobulin mediated immune response (GO:0002889)3.47605601
68heterotypic cell-cell adhesion (GO:0034113)3.46776662
69T cell differentiation (GO:0030217)3.45359713
70negative regulation of lymphocyte mediated immunity (GO:0002707)3.45072969
71T cell activation (GO:0042110)3.40949863
72regulation of lymphocyte mediated immunity (GO:0002706)3.40370470
73regulation of necroptotic process (GO:0060544)3.37065320
74regulation of B cell mediated immunity (GO:0002712)3.35016133
75positive regulation of interferon-gamma production (GO:0032729)3.34991727
76positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.33138907
77immunoglobulin mediated immune response (GO:0016064)3.32710366
78regulation of tolerance induction (GO:0002643)3.28650220
79negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.27492332
80positive regulation of T cell activation (GO:0050870)3.26325179
81positive regulation of lymphocyte mediated immunity (GO:0002708)3.24947816
82positive regulation of immunoglobulin mediated immune response (GO:0002891)3.24192567
83positive regulation of B cell mediated immunity (GO:0002714)3.24192567
84regulation of isotype switching (GO:0045191)3.22102485
85regulation of interleukin-2 biosynthetic process (GO:0045076)3.21509349
86positive regulation of interleukin-2 production (GO:0032743)3.21395420
87negative regulation of T cell mediated immunity (GO:0002710)3.21010570
88regulation of immunoglobulin production (GO:0002637)3.18233135
89immune response-activating cell surface receptor signaling pathway (GO:0002429)3.18147770
90cellular response to interleukin-4 (GO:0071353)3.18082450
91regulation of interleukin-8 secretion (GO:2000482)3.15812140
92negative regulation of T cell receptor signaling pathway (GO:0050860)3.15442633
93regulation of T cell mediated immunity (GO:0002709)3.14703025
94cytokine biosynthetic process (GO:0042089)3.14318109
95positive regulation of alpha-beta T cell proliferation (GO:0046641)3.12022357
96membrane raft organization (GO:0031579)3.11045619
97regulation of alpha-beta T cell proliferation (GO:0046640)3.09640311
98regulation of regulatory T cell differentiation (GO:0045589)3.09609399
99negative regulation of stress fiber assembly (GO:0051497)3.09445543
100regulation of interleukin-4 production (GO:0032673)3.08927007

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse6.90654523
2IRF8_22096565_ChIP-ChIP_GC-B_Human6.46255164
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.59077868
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.41988457
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.14987208
6IRF8_21731497_ChIP-ChIP_J774_Mouse3.82667212
7STAT4_19710469_ChIP-ChIP_TH1__Mouse3.80276494
8STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.52334462
9RUNX_20019798_ChIP-Seq_JUKART_Human3.42627367
10MAF_26560356_Chip-Seq_TH1_Human3.10949042
11MYB_26560356_Chip-Seq_TH2_Human3.09389052
12MYC_22102868_ChIP-Seq_BL_Human3.08916091
13RUNX1_20887958_ChIP-Seq_HPC-7_Mouse3.01819032
14FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.98681240
15MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.94857702
16SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.90037109
17UTX_26944678_Chip-Seq_JUKART_Human2.87390565
18MYB_26560356_Chip-Seq_TH1_Human2.61790125
19NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.44154606
20SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.30099772
21FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.27642741
22MAF_26560356_Chip-Seq_TH2_Human2.27437755
23EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.22402863
24NOTCH1_21737748_ChIP-Seq_TLL_Human1.99850646
25GATA3_27048872_Chip-Seq_THYMUS_Human1.95841086
26E2F7_22180533_ChIP-Seq_HELA_Human1.92376845
27RUNX1_22412390_ChIP-Seq_EML_Mouse1.88946874
28SPI1_23547873_ChIP-Seq_NB4_Human1.85080444
29TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.82903107
30EGR1_19374776_ChIP-ChIP_THP-1_Human1.82619949
31VDR_21846776_ChIP-Seq_THP-1_Human1.78206168
32E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.71682163
33NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.71458403
34MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.70209296
35KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.66674801
36BP1_19119308_ChIP-ChIP_Hs578T_Human1.64981881
37IRF8_27001747_Chip-Seq_BMDM_Mouse1.62174511
38SMAD_19615063_ChIP-ChIP_OVARY_Human1.57959774
39HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.56598238
40MYB_21317192_ChIP-Seq_ERMYB_Mouse1.55523928
41SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.48476833
42VDR_24763502_ChIP-Seq_THP-1_Human1.40572885
43SPI1_23127762_ChIP-Seq_K562_Human1.39475024
44NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.38621815
45TCF7_22412390_ChIP-Seq_EML_Mouse1.38555781
46SCL_19346495_ChIP-Seq_HPC-7_Human1.37207929
47SRY_22984422_ChIP-ChIP_TESTIS_Rat1.34443588
48BRD4_27068464_Chip-Seq_AML-cells_Mouse1.32424045
49GATA2_22383799_ChIP-Seq_G1ME_Mouse1.28453821
50CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.23815365
51E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.23723987
52VDR_23849224_ChIP-Seq_CD4+_Human1.23151888
53GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.21279554
54KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.20613172
55RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.19140383
56ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.19106270
57SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.17457076
58KDM2B_26808549_Chip-Seq_DND41_Human1.13921166
59NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.13013276
60CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.12149315
61GATA3_26560356_Chip-Seq_TH2_Human1.10908999
62ELF1_17652178_ChIP-ChIP_JURKAT_Human1.10041916
63LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.09878092
64RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.09008986
65PU.1_20513432_ChIP-Seq_Bcells_Mouse1.08040953
66GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.07797545
67ERG_20887958_ChIP-Seq_HPC-7_Mouse1.07721361
68PU_27001747_Chip-Seq_BMDM_Mouse1.04626795
69LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.03292377
70TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02697765
71CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02016074
72FOXP3_21729870_ChIP-Seq_TREG_Human1.01714288
73KDM2B_26808549_Chip-Seq_SUP-B15_Human1.00186102
74CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99244412
75ELK3_25401928_ChIP-Seq_HUVEC_Human0.96958801
76SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96907976
77HOXB4_20404135_ChIP-ChIP_EML_Mouse0.94419956
78PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93890691
79LXR_22292898_ChIP-Seq_THP-1_Human0.92840922
80EGR1_19032775_ChIP-ChIP_M12_Human0.92772394
81JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.92218937
82SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.91293603
83CIITA_25753668_ChIP-Seq_RAJI_Human0.90449746
84FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89154752
85GATA1_22025678_ChIP-Seq_K562_Human0.85890379
86GATA1_22383799_ChIP-Seq_G1ME_Mouse0.85400051
87SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.85339650
88BCL6_27268052_Chip-Seq_Bcells_Human0.83937802
89RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83300373
90STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.80490577
91RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.77563709
92FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.75989260
93CTCF_26484167_Chip-Seq_Bcells_Mouse0.75130561
94TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.74918997
95MYC_18555785_ChIP-Seq_MESCs_Mouse0.74426122
96KDM2B_26808549_Chip-Seq_JURKAT_Human0.74136647
97XRN2_22483619_ChIP-Seq_HELA_Human0.74077766
98GABP_17652178_ChIP-ChIP_JURKAT_Human0.73700765
99PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.72358004
100P68_20966046_ChIP-Seq_HELA_Human0.71363383

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology6.13624544
2MP0005671_abnormal_response_to6.05162949
3MP0002166_altered_tumor_susceptibility4.33997344
4MP0001835_abnormal_antigen_presentation4.20687914
5MP0009785_altered_susceptibility_to3.63090871
6MP0000685_abnormal_immune_system3.56214018
7MP0002006_tumorigenesis3.32786894
8MP0005000_abnormal_immune_tolerance3.19006509
9MP0001800_abnormal_humoral_immune2.99331131
10MP0005387_immune_system_phenotype2.97511058
11MP0001790_abnormal_immune_system2.97511058
12MP0005025_abnormal_response_to2.85417057
13MP0002420_abnormal_adaptive_immunity2.82701572
14MP0001819_abnormal_immune_cell2.79855870
15MP0002723_abnormal_immune_serum2.79080972
16MP0002398_abnormal_bone_marrow2.76874984
17MP0006082_CNS_inflammation2.70038966
18MP0009333_abnormal_splenocyte_physiolog2.67292647
19MP0003724_increased_susceptibility_to2.53746425
20MP0010155_abnormal_intestine_physiology2.49149899
21MP0000716_abnormal_immune_system2.48550175
22MP0000703_abnormal_thymus_morphology2.41552465
23MP0002452_abnormal_antigen_presenting2.38088839
24MP0002722_abnormal_immune_system2.37626170
25MP0002933_joint_inflammation2.30073086
26MP0004510_myositis2.27874114
27MP0000689_abnormal_spleen_morphology2.15661492
28MP0002405_respiratory_system_inflammati2.14872091
29MP0003866_abnormal_defecation2.09181025
30MP0002396_abnormal_hematopoietic_system2.01890066
31MP0005310_abnormal_salivary_gland2.01689727
32MP0002429_abnormal_blood_cell1.97098101
33MP0004381_abnormal_hair_follicle1.96038038
34MP0002419_abnormal_innate_immunity1.87192139
35MP0001873_stomach_inflammation1.80890580
36MP0004947_skin_inflammation1.80458510
37MP0001348_abnormal_lacrimal_gland1.74277302
38MP0001845_abnormal_inflammatory_respons1.66716632
39MP0003436_decreased_susceptibility_to1.65526662
40MP0002148_abnormal_hypersensitivity_rea1.50308079
41MP0001853_heart_inflammation1.47916187
42MP0003300_gastrointestinal_ulcer1.45243614
43MP0002009_preneoplasia1.39543941
44MP0008469_abnormal_protein_level1.35131777
45MP0000858_altered_metastatic_potential1.33773708
46MP0009764_decreased_sensitivity_to1.24074454
47MP0005464_abnormal_platelet_physiology1.20970855
48MP0003303_peritoneal_inflammation1.10967548
49MP0004808_abnormal_hematopoietic_stem1.05734083
50MP0001851_eye_inflammation1.02349743
51MP0003448_altered_tumor_morphology1.01938844
52MP0002163_abnormal_gland_morphology1.01576615
53MP0002019_abnormal_tumor_incidence0.96513656
54MP0009763_increased_sensitivity_to0.90482165
55MP0002132_abnormal_respiratory_system0.88823670
56MP0001533_abnormal_skeleton_physiology0.83544319
57MP0000465_gastrointestinal_hemorrhage0.77996308
58MP0002998_abnormal_bone_remodeling0.77755387
59MP0005075_abnormal_melanosome_morpholog0.74983432
60MP0000015_abnormal_ear_pigmentation0.70732309
61MP0005023_abnormal_wound_healing0.69891212
62MP0002138_abnormal_hepatobiliary_system0.67976156
63MP0000343_altered_response_to0.66376589
64MP0000477_abnormal_intestine_morphology0.65571775
65MP0002822_catalepsy0.64707853
66MP0002693_abnormal_pancreas_physiology0.64290146
67MP0009765_abnormal_xenobiotic_induced0.62740884
68MP0010352_gastrointestinal_tract_polyps0.61801302
69MP0005397_hematopoietic_system_phenotyp0.55956492
70MP0001545_abnormal_hematopoietic_system0.55956492
71MP0000490_abnormal_crypts_of0.55068195
72MP0008961_abnormal_basal_metabolism0.53845130
73MP0008872_abnormal_physiological_respon0.52024051
74MP0003795_abnormal_bone_structure0.51598236
75MP0000249_abnormal_blood_vessel0.50163520
76MP0003191_abnormal_cellular_cholesterol0.48473684
77MP0000609_abnormal_liver_physiology0.48216692
78MP0009379_abnormal_foot_pigmentation0.48023855
79MP0002909_abnormal_adrenal_gland0.47136078
80MP0009840_abnormal_foam_cell0.46911904
81MP0010234_abnormal_vibrissa_follicle0.45968118
82MP0001191_abnormal_skin_condition0.43390157
83MP0003045_fibrosis0.40458021
84MP0000604_amyloidosis0.39611213
85MP0001663_abnormal_digestive_system0.38665978
86MP0000313_abnormal_cell_death0.38531081
87MP0002928_abnormal_bile_duct0.37283209
88MP0001764_abnormal_homeostasis0.36964323
89MP0009642_abnormal_blood_homeostasis0.35424666
90MP0002083_premature_death0.34816120
91MP0003566_abnormal_cell_adhesion0.34068501
92MP0003221_abnormal_cardiomyocyte_apopto0.33013687
93MP0000598_abnormal_liver_morphology0.32848410
94MP0005174_abnormal_tail_pigmentation0.30785274
95MP0002095_abnormal_skin_pigmentation0.30724205
96MP0005379_endocrine/exocrine_gland_phen0.30724190
97MP0003879_abnormal_hair_cell0.28749626
98MP0008873_increased_physiological_sensi0.27978783
99MP0008770_decreased_survivor_rate0.27128608
100MP0005451_abnormal_body_composition0.26808985

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)7.81380817
2Severe combined immunodeficiency (HP:0004430)7.60078747
3Abnormality of T cell number (HP:0011839)7.44469736
4Recurrent bronchitis (HP:0002837)6.79247569
5Elevated erythrocyte sedimentation rate (HP:0003565)6.73068747
6Combined immunodeficiency (HP:0005387)6.70442734
7IgG deficiency (HP:0004315)6.21988401
8Hypoplasia of the thymus (HP:0000778)5.94111114
9Thyroiditis (HP:0100646)5.91750564
10IgM deficiency (HP:0002850)5.85861757
11Abnormality of T cells (HP:0002843)5.74209082
12Increased IgM level (HP:0003496)5.44186352
13Chronic mucocutaneous candidiasis (HP:0002728)5.17955093
14Recurrent cutaneous fungal infections (HP:0011370)5.17955093
15Abnormality of B cell number (HP:0010975)5.00059903
16B lymphocytopenia (HP:0010976)5.00059903
17Stomatitis (HP:0010280)4.91804429
18Chronic diarrhea (HP:0002028)4.87842000
19Abnormality of eosinophils (HP:0001879)4.76305406
20Lymphopenia (HP:0001888)4.38511926
21Myositis (HP:0100614)4.20121506
22Abnormality of cells of the lymphoid lineage (HP:0012140)4.15333457
23Autoimmune hemolytic anemia (HP:0001890)4.02340057
24Recurrent fungal infections (HP:0002841)3.82541001
25Bronchitis (HP:0012387)3.79881458
26Leukocytosis (HP:0001974)3.75517784
27Abnormality of T cell physiology (HP:0011840)3.73049872
28Recurrent sinusitis (HP:0011108)3.38036101
29Agammaglobulinemia (HP:0004432)3.32695385
30IgA deficiency (HP:0002720)3.29603763
31Hypergammaglobulinemia (HP:0010702)3.09143207
32Recurrent otitis media (HP:0000403)3.03054982
33Vasculitis (HP:0002633)2.98525516
34Reduced subcutaneous adipose tissue (HP:0003758)2.94553977
35Eczematoid dermatitis (HP:0000976)2.92895029
36Orchitis (HP:0100796)2.92601063
37Lymphoma (HP:0002665)2.92299873
38Chronic otitis media (HP:0000389)2.88726421
39Eosinophilia (HP:0001880)2.78840342
40Amyotrophic lateral sclerosis (HP:0007354)2.76555751
41Microcytic anemia (HP:0001935)2.76085917
42Joint swelling (HP:0001386)2.75063843
43Recurrent skin infections (HP:0001581)2.72403085
44Obstructive lung disease (HP:0006536)2.56740134
45Chronic obstructive pulmonary disease (HP:0006510)2.56740134
46Pustule (HP:0200039)2.56654615
47Large eyes (HP:0001090)2.56213925
48Recurrent viral infections (HP:0004429)2.54679965
49Optic neuritis (HP:0100653)2.52395418
50Retrobulbar optic neuritis (HP:0100654)2.52395418
51Panhypogammaglobulinemia (HP:0003139)2.47912958
52Pulmonary infiltrates (HP:0002113)2.47907420
53Granulocytopenia (HP:0001913)2.47024646
54Gastrointestinal stroma tumor (HP:0100723)2.43152664
55Type 2 muscle fiber atrophy (HP:0003554)2.40907146
56Hypoproteinemia (HP:0003075)2.35243076
57Recurrent abscess formation (HP:0002722)2.31985037
58Nasal polyposis (HP:0100582)2.31653130
59Poikiloderma (HP:0001029)2.28481638
60Muscle fiber atrophy (HP:0100295)2.28325214
61Abnormality of the nasal mucosa (HP:0000433)2.27787408
62Hemoptysis (HP:0002105)2.22076325
63Aplasia/Hypoplasia of the thymus (HP:0010515)2.18955955
64Meningitis (HP:0001287)2.16274510
65Radial bowing (HP:0002986)2.12027150
66Mediastinal lymphadenopathy (HP:0100721)2.03533436
67Gingivitis (HP:0000230)2.02637978
68Anorexia (HP:0002039)2.01921098
69Entropion (HP:0000621)1.97725689
70Abnormality of the fingertips (HP:0001211)1.97647000
71Thrombocytosis (HP:0001894)1.95182191
72Basal cell carcinoma (HP:0002671)1.93526535
73Sepsis (HP:0100806)1.92451415
74Gastrointestinal infarctions (HP:0005244)1.87593456
75Skin rash (HP:0000988)1.86748763
76Urticaria (HP:0001025)1.83497024
77Spontaneous hematomas (HP:0007420)1.83261415
78Gingival bleeding (HP:0000225)1.77375579
79Emphysema (HP:0002097)1.76991768
80Epistaxis (HP:0000421)1.75180547
81Pulmonary embolism (HP:0002204)1.72646625
82Gangrene (HP:0100758)1.71493287
83Ureteral stenosis (HP:0000071)1.70650926
84Arthralgia (HP:0002829)1.70480349
85Keratoconjunctivitis sicca (HP:0001097)1.68898494
86Premature skin wrinkling (HP:0100678)1.68627463
87Abnormality of macrophages (HP:0004311)1.67907928
88Encephalitis (HP:0002383)1.66976881
89Bronchiectasis (HP:0002110)1.65827043
90Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.65482563
91Decreased activity of mitochondrial respiratory chain (HP:0008972)1.65482563
92Abnormality of the pleura (HP:0002103)1.64282125
93Polyneuropathy (HP:0001271)1.63518686
94Petechiae (HP:0000967)1.63463665
95Bicuspid aortic valve (HP:0001647)1.61632101
96Facial edema (HP:0000282)1.61600867
97Periorbital edema (HP:0100539)1.61011528
98Abnormality of the prostate (HP:0008775)1.59461236
99Abnormality of the thymus (HP:0000777)1.58240801
100Increased density of long bones (HP:0006392)1.58221655

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK6.09037672
2KDR5.32091927
3MAP4K14.08829388
4ZAP704.01732848
5TESK23.24408362
6MAP3K123.15437414
7FGFR42.98659785
8BLK2.93178183
9IKBKE2.88269974
10NME22.85497788
11ITK2.47670818
12TYK22.20866584
13TBK12.11574132
14JAK12.04917936
15JAK32.04136622
16LCK1.92259917
17TEC1.91328678
18GRK61.88272848
19ERN11.84490536
20SYK1.83505725
21NLK1.70827613
22BTK1.62100192
23HCK1.54102048
24FGFR31.52735545
25CSK1.51757051
26TESK11.43771660
27EIF2AK11.26641004
28KIT1.20993059
29TNK21.18752945
30STK101.16438048
31MYLK1.09906711
32MAP3K141.00989480
33TLK10.98989199
34DAPK30.98763854
35LYN0.98517265
36MAP2K60.96447049
37IRAK40.92989605
38SIK10.91922071
39FYN0.86326566
40NEK90.85141724
41PRKCQ0.82489220
42SCYL20.80840343
43SIK20.79683849
44LIMK10.75768631
45SIK30.75301253
46INSR0.72335737
47FLT30.64664516
48LRRK20.62939528
49PDGFRB0.61418695
50CLK10.60239543
51PRKCH0.59105756
52EIF2AK30.55136523
53JAK20.54497610
54DAPK10.52210498
55ILK0.50831812
56FGFR10.48967245
57IKBKB0.48469956
58PDK40.45810855
59PDK30.45810855
60IGF1R0.45302112
61TGFBR20.41973355
62FGFR20.40790862
63MAP2K70.40369548
64MAPK110.39308586
65ROCK10.39057445
66CSF1R0.36732299
67MARK20.34932404
68MAP3K130.34190388
69FES0.33916102
70MAP3K70.33126328
71EEF2K0.32366779
72SRC0.30702123
73HIPK20.29644643
74PDK10.29597247
75STK40.29540325
76ALK0.29244553
77CSNK1A1L0.28750291
78PRKCD0.26131654
79MARK30.25590189
80MAPK30.25448077
81CSNK1G30.24040730
82PRKG20.23557262
83CSNK1G10.22655992
84TAOK30.22417247
85STK160.20872064
86PKN20.20693081
87AURKB0.19363309
88MST40.18648616
89CAMK10.18565253
90TGFBR10.18155725
91PRKD10.17117700
92TYRO30.15195710
93ROCK20.15121703
94CHUK0.14651424
95MAPK90.14502886
96PRKCB0.14160979
97PASK0.13946974
98MAPK120.13615981
99PTK20.13206310
100PRKD20.12526461

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053407.79127241
2T cell receptor signaling pathway_Homo sapiens_hsa046604.08153894
3Hematopoietic cell lineage_Homo sapiens_hsa046403.61879403
4Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046503.39369070
5Intestinal immune network for IgA production_Homo sapiens_hsa046723.26737134
6Measles_Homo sapiens_hsa051623.16926309
7Inflammatory bowel disease (IBD)_Homo sapiens_hsa053213.14863073
8Allograft rejection_Homo sapiens_hsa053302.46979872
9NF-kappa B signaling pathway_Homo sapiens_hsa040642.39702323
10Antigen processing and presentation_Homo sapiens_hsa046122.35799750
11Asthma_Homo sapiens_hsa053102.12192481
12Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.98714164
13Autoimmune thyroid disease_Homo sapiens_hsa053201.93394460
14Proteasome_Homo sapiens_hsa030501.84311026
15Viral myocarditis_Homo sapiens_hsa054161.83667650
16Sulfur relay system_Homo sapiens_hsa041221.82418063
17Leishmaniasis_Homo sapiens_hsa051401.73104977
18Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.70703093
19RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.70289918
20Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.67837038
21Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.61691105
22Jak-STAT signaling pathway_Homo sapiens_hsa046301.58874491
23Other glycan degradation_Homo sapiens_hsa005111.56685712
24Ribosome_Homo sapiens_hsa030101.45212966
25Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.42565835
26Herpes simplex infection_Homo sapiens_hsa051681.39843855
27Osteoclast differentiation_Homo sapiens_hsa043801.39813387
28Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.14273256
29Nucleotide excision repair_Homo sapiens_hsa034201.13162963
30Chemokine signaling pathway_Homo sapiens_hsa040621.11450226
31Malaria_Homo sapiens_hsa051441.09501659
32Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.08028217
33Graft-versus-host disease_Homo sapiens_hsa053321.04459298
34Leukocyte transendothelial migration_Homo sapiens_hsa046701.00782902
35HTLV-I infection_Homo sapiens_hsa051660.98099671
36Shigellosis_Homo sapiens_hsa051310.94585576
37B cell receptor signaling pathway_Homo sapiens_hsa046620.93396045
38Mismatch repair_Homo sapiens_hsa034300.89016048
39Toxoplasmosis_Homo sapiens_hsa051450.86574126
40Salmonella infection_Homo sapiens_hsa051320.86428377
41Viral carcinogenesis_Homo sapiens_hsa052030.84795529
42Hepatitis B_Homo sapiens_hsa051610.83685196
43RNA polymerase_Homo sapiens_hsa030200.81435612
44Apoptosis_Homo sapiens_hsa042100.77612121
45DNA replication_Homo sapiens_hsa030300.75716138
46Toll-like receptor signaling pathway_Homo sapiens_hsa046200.74289518
47Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.72672851
48Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.71905067
49Spliceosome_Homo sapiens_hsa030400.71042607
50Staphylococcus aureus infection_Homo sapiens_hsa051500.65859846
51Protein export_Homo sapiens_hsa030600.64869875
52Influenza A_Homo sapiens_hsa051640.62607231
53Hepatitis C_Homo sapiens_hsa051600.62107329
54Non-homologous end-joining_Homo sapiens_hsa034500.59222394
55VEGF signaling pathway_Homo sapiens_hsa043700.57086391
56NOD-like receptor signaling pathway_Homo sapiens_hsa046210.55790943
57Pancreatic cancer_Homo sapiens_hsa052120.53518804
58Acute myeloid leukemia_Homo sapiens_hsa052210.52699724
59p53 signaling pathway_Homo sapiens_hsa041150.50068080
60Tuberculosis_Homo sapiens_hsa051520.49683196
61Legionellosis_Homo sapiens_hsa051340.48333904
62TNF signaling pathway_Homo sapiens_hsa046680.45820052
63Colorectal cancer_Homo sapiens_hsa052100.43349400
64Prolactin signaling pathway_Homo sapiens_hsa049170.41795272
65Sphingolipid signaling pathway_Homo sapiens_hsa040710.41564525
66Thyroid cancer_Homo sapiens_hsa052160.41166009
67Pentose phosphate pathway_Homo sapiens_hsa000300.40120641
68Epstein-Barr virus infection_Homo sapiens_hsa051690.39936603
69Pertussis_Homo sapiens_hsa051330.38608067
70Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.37498507
71Regulation of actin cytoskeleton_Homo sapiens_hsa048100.35479335
72African trypanosomiasis_Homo sapiens_hsa051430.34594970
73Pyrimidine metabolism_Homo sapiens_hsa002400.34133380
74Platelet activation_Homo sapiens_hsa046110.33235033
75RNA degradation_Homo sapiens_hsa030180.32994284
76Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.32745216
77Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.32643349
78Base excision repair_Homo sapiens_hsa034100.31531025
79Type I diabetes mellitus_Homo sapiens_hsa049400.30243708
80Endocytosis_Homo sapiens_hsa041440.26715651
81Rap1 signaling pathway_Homo sapiens_hsa040150.25114949
82Phosphatidylinositol signaling system_Homo sapiens_hsa040700.19823464
83Transcriptional misregulation in cancer_Homo sapiens_hsa052020.18891058
84Basal transcription factors_Homo sapiens_hsa030220.18262387
85Cyanoamino acid metabolism_Homo sapiens_hsa004600.15410707
86Lysosome_Homo sapiens_hsa041420.14959125
87Notch signaling pathway_Homo sapiens_hsa043300.13802665
88Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.11231911
89Adherens junction_Homo sapiens_hsa045200.08426006
90Adipocytokine signaling pathway_Homo sapiens_hsa049200.07427212
91Non-small cell lung cancer_Homo sapiens_hsa052230.05061289
92Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.02901056
93Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.02696082
94Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.02345217
95Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.01860862
96Choline metabolism in cancer_Homo sapiens_hsa052310.00080786
97Systemic lupus erythematosus_Homo sapiens_hsa05322-0.0323726
98AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933-0.0115996
99RNA transport_Homo sapiens_hsa03013-0.0079359
100Glycerophospholipid metabolism_Homo sapiens_hsa00564-0.0027994

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