TRBV10-2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of hormone biosynthetic process (GO:0046886)9.42587313
2positive regulation of fibroblast migration (GO:0010763)8.56202353
3positive regulation of protein sumoylation (GO:0033235)7.65450551
4mRNA transcription from RNA polymerase II promoter (GO:0042789)7.01693230
5positive regulation of hormone metabolic process (GO:0032352)6.89142759
6negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)6.88765062
7positive regulation of glycolytic process (GO:0045821)6.85392458
8negative regulation of heart rate (GO:0010459)6.74732171
9mRNA cleavage (GO:0006379)6.25703499
10mRNA transcription (GO:0009299)6.04990554
11regulation of glomerular filtration (GO:0003093)6.02985772
12nerve growth factor signaling pathway (GO:0038180)5.84321341
13negative regulation of T cell mediated immunity (GO:0002710)5.75031605
14positive regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030949)5.61627879
15negative regulation of interleukin-2 production (GO:0032703)5.44311412
16NIK/NF-kappaB signaling (GO:0038061)5.05626304
17positive regulation of T cell cytokine production (GO:0002726)5.04150253
18positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)4.99014020
19positive regulation of natural killer cell mediated immunity (GO:0002717)4.98740952
20response to nerve growth factor (GO:1990089)4.92575869
21cellular response to nerve growth factor stimulus (GO:1990090)4.92575869
22positive regulation of erythrocyte differentiation (GO:0045648)4.80763824
23positive regulation of leukocyte mediated cytotoxicity (GO:0001912)4.79234780
24T-helper cell differentiation (GO:0042093)4.77761965
25CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)4.77761965
26regulation of natural killer cell mediated immunity (GO:0002715)4.64096551
27regulation of natural killer cell mediated cytotoxicity (GO:0042269)4.64096551
28regulation of protein sumoylation (GO:0033233)4.56023611
29cellular response to nicotine (GO:0071316)4.54014363
30positive regulation of circadian rhythm (GO:0042753)4.49931424
31cellular response to interleukin-4 (GO:0071353)4.38396097
32positive regulation of T cell chemotaxis (GO:0010820)4.38361348
33regulation of T cell chemotaxis (GO:0010819)4.38361348
34positive regulation of T cell mediated cytotoxicity (GO:0001916)4.35493239
35positive regulation of granulocyte differentiation (GO:0030854)4.35477460
36regulation of circadian sleep/wake cycle (GO:0042749)4.23981292
37regulation of circadian sleep/wake cycle, sleep (GO:0045187)4.23981292
38positive regulation of cell killing (GO:0031343)4.23938153
39alpha-beta T cell differentiation involved in immune response (GO:0002293)4.23293075
40alpha-beta T cell activation involved in immune response (GO:0002287)4.23293075
41T cell differentiation involved in immune response (GO:0002292)4.23293075
42negative regulation of lymphocyte mediated immunity (GO:0002707)4.21720720
43regulation of leukocyte mediated cytotoxicity (GO:0001910)4.20590087
44L-fucose catabolic process (GO:0042355)4.19629800
45fucose catabolic process (GO:0019317)4.19629800
46L-fucose metabolic process (GO:0042354)4.19629800
47activated T cell proliferation (GO:0050798)4.14398799
48renal system process involved in regulation of blood volume (GO:0001977)4.12894840
49positive regulation of T-helper 1 type immune response (GO:0002827)4.12773381
50negative regulation of alpha-beta T cell activation (GO:0046636)4.09003628
51protein polyglutamylation (GO:0018095)3.93636095
52negative regulation of cytokine production involved in immune response (GO:0002719)3.89587087
53positive regulation vascular endothelial growth factor production (GO:0010575)3.89157878
54lymphocyte chemotaxis (GO:0048247)3.88503539
55radial glial cell differentiation (GO:0060019)3.86202348
56regulation of T cell cytokine production (GO:0002724)3.85862856
57response to interleukin-4 (GO:0070670)3.83325032
58regulation of T cell mediated cytotoxicity (GO:0001914)3.81390725
59regulation of cell killing (GO:0031341)3.76111657
60negative regulation of glycoprotein biosynthetic process (GO:0010561)3.73281410
61regulation of memory T cell differentiation (GO:0043380)3.71942034
62regulation of interleukin-2 biosynthetic process (GO:0045076)3.66661748
63positive regulation of alpha-beta T cell proliferation (GO:0046641)3.66184824
64regulation of glycolytic process (GO:0006110)3.65647186
65positive regulation of type 2 immune response (GO:0002830)3.60400577
66regulation of alpha-beta T cell proliferation (GO:0046640)3.58434825
67negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.53563933
68regulation of hormone biosynthetic process (GO:0046885)3.50447372
69CD4-positive, alpha-beta T cell differentiation (GO:0043367)3.48269704
70regulation of urine volume (GO:0035809)3.47974479
71interkinetic nuclear migration (GO:0022027)3.45995601
72positive regulation of response to biotic stimulus (GO:0002833)3.45723553
73embryonic placenta development (GO:0001892)3.44484603
74response to interleukin-15 (GO:0070672)3.44367092
75cellular response to interleukin-15 (GO:0071350)3.42551791
76regulation of fibroblast migration (GO:0010762)3.39856158
77regulation of superoxide anion generation (GO:0032928)3.38297607
78renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)3.37558960
79positive regulation of heart rate (GO:0010460)3.35620167
80regulation of vascular endothelial growth factor production (GO:0010574)3.33514184
81positive regulation by host of viral transcription (GO:0043923)3.28667159
82circadian sleep/wake cycle process (GO:0022410)3.27012406
83regulation of T-helper 1 type immune response (GO:0002825)3.26261850
84negative regulation of production of molecular mediator of immune response (GO:0002701)3.23630381
85negative regulation of necroptotic process (GO:0060546)3.22563314
86positive regulation of gamma-delta T cell activation (GO:0046645)3.22411612
87negative regulation of leukocyte mediated immunity (GO:0002704)3.22355184
88negative regulation of reactive oxygen species metabolic process (GO:2000378)3.21004054
89regulation of transcription from RNA polymerase II promoter in response to hypoxia (GO:0061418)3.20261386
90developmental pigmentation (GO:0048066)3.20120843
91detection of temperature stimulus involved in sensory perception (GO:0050961)3.15976072
92detection of temperature stimulus involved in sensory perception of pain (GO:0050965)3.15976072
93regulation of renal sodium excretion (GO:0035813)3.13791871
94negative regulation of adaptive immune response (GO:0002820)3.13699380
95tongue development (GO:0043586)3.12946145
96regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)3.12724638
97negative regulation of heart contraction (GO:0045822)3.12022144
98regulation of RIG-I signaling pathway (GO:0039535)11.7222365
99regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:004311.0593164
100regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)10.3543439

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.85412911
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.67318574
3CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human5.26666397
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.05987961
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse4.02906714
6FLI1_27457419_Chip-Seq_LIVER_Mouse3.84971337
7STAT6_21828071_ChIP-Seq_BEAS2B_Human3.45536780
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.45223047
9IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.22913524
10SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.04121810
11ELF1_17652178_ChIP-ChIP_JURKAT_Human2.95017152
12IRF8_22096565_ChIP-ChIP_GC-B_Human2.88857604
13PCGF2_27294783_Chip-Seq_ESCs_Mouse2.82767502
14E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.82664256
15STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.62748112
16RUNX_20019798_ChIP-Seq_JUKART_Human2.57519791
17PCGF2_27294783_Chip-Seq_NPCs_Mouse2.44903530
18MYB_26560356_Chip-Seq_TH2_Human2.43972411
19GATA1_22025678_ChIP-Seq_K562_Human2.38545031
20BP1_19119308_ChIP-ChIP_Hs578T_Human2.37894904
21STAT4_19710469_ChIP-ChIP_TH1__Mouse2.35451171
22MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.32399782
23IRF1_19129219_ChIP-ChIP_H3396_Human2.29793094
24SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.29287348
25IRF8_21731497_ChIP-ChIP_J774_Mouse2.19015535
26NOTCH1_21737748_ChIP-Seq_TLL_Human2.14791447
27MYB_21317192_ChIP-Seq_ERMYB_Mouse2.09811211
28FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.99050989
29SPI1_23547873_ChIP-Seq_NB4_Human1.86424891
30CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.80916884
31ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.78271891
32RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.74388754
33MYB_26560356_Chip-Seq_TH1_Human1.71030393
34GATA3_27048872_Chip-Seq_THYMUS_Human1.68372614
35UTX_26944678_Chip-Seq_JUKART_Human1.62367566
36IRF8_27001747_Chip-Seq_BMDM_Mouse1.60720967
37GATA3_26560356_Chip-Seq_TH2_Human1.59071351
38SUZ12_27294783_Chip-Seq_NPCs_Mouse1.57064423
39SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.52649142
40MAF_26560356_Chip-Seq_TH1_Human1.47791944
41NFE2_27457419_Chip-Seq_LIVER_Mouse1.47089376
42EGR1_19032775_ChIP-ChIP_M12_Human1.44485693
43SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.44405976
44SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.44002756
45E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.35133953
46SPI1_23127762_ChIP-Seq_K562_Human1.33962354
47CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.28509085
48FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.28468240
49CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.28326866
50MAF_26560356_Chip-Seq_TH2_Human1.21898346
51GABP_17652178_ChIP-ChIP_JURKAT_Human1.19785621
52GATA2_22383799_ChIP-Seq_G1ME_Mouse1.18744964
53PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.13703591
54VDR_23849224_ChIP-Seq_CD4+_Human1.12473330
55CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.08983882
56DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.06831194
57HOXB4_20404135_ChIP-ChIP_EML_Mouse1.05944902
58NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.00622196
59MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.99523365
60RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.98878161
61CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97464149
62LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96182978
63GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.95395265
64NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.94704304
65RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.90979956
66BRD4_27068464_Chip-Seq_AML-cells_Mouse0.90757952
67SPI1_26923725_Chip-Seq_HPCs_Mouse0.88289572
68EZH2_27294783_Chip-Seq_NPCs_Mouse0.87067425
69FOXP3_21729870_ChIP-Seq_TREG_Human0.86537312
70GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85987365
71TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.83368952
72PU_27001747_Chip-Seq_BMDM_Mouse0.82107412
73GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.81741043
74FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78741339
75CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.78620500
76CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.78253532
77SMRT_27268052_Chip-Seq_Bcells_Human0.77787731
78VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.77700018
79BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.77612050
80RBPJ_21746931_ChIP-Seq_IB4_Human0.75653574
81RUNX1_22412390_ChIP-Seq_EML_Mouse0.73042911
82PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.71742395
83PU.1_20513432_ChIP-Seq_Bcells_Mouse0.71508908
84MYC_22102868_ChIP-Seq_BL_Human0.70309576
85CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.69183371
86ERG_20887958_ChIP-Seq_HPC-7_Mouse0.67819079
87SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.67789507
88GATA2_19941826_ChIP-Seq_K562_Human0.65794888
89OCT4_21477851_ChIP-Seq_ESCs_Mouse0.65110777
90EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.64777692
91TP53_22573176_ChIP-Seq_HFKS_Human0.64509110
92STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.64505608
93SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.64259128
94TCF7_22412390_ChIP-Seq_EML_Mouse0.64250183
95CRX_20693478_ChIP-Seq_RETINA_Mouse0.64042598
96CTCF_27219007_Chip-Seq_ERYTHROID_Human0.63933744
97BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human0.63675635
98TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.62465941
99ERA_21632823_ChIP-Seq_H3396_Human0.62429397
100BCOR_27268052_Chip-Seq_Bcells_Human0.62375064

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation5.00890609
2MP0004381_abnormal_hair_follicle4.53454919
3MP0003724_increased_susceptibility_to4.11512974
4MP0001790_abnormal_immune_system4.07869727
5MP0005387_immune_system_phenotype4.07869727
6MP0008260_abnormal_autophagy3.91043725
7MP0000372_irregular_coat_pigmentation3.68839868
8MP0005075_abnormal_melanosome_morpholog3.53791089
9MP0005671_abnormal_response_to2.98362691
10MP0002796_impaired_skin_barrier2.85879673
11MP0004510_myositis2.80486516
12MP0001800_abnormal_humoral_immune2.63991184
13MP0001853_heart_inflammation2.53464580
14MP0001873_stomach_inflammation2.43834589
15MP0002254_reproductive_system_inflammat2.42314880
16MP0002138_abnormal_hepatobiliary_system2.40805049
17MP0006082_CNS_inflammation2.36442506
18MP0009333_abnormal_splenocyte_physiolog2.30324672
19MP0003763_abnormal_thymus_physiology2.30293644
20MP0000685_abnormal_immune_system2.22837210
21MP0003172_abnormal_lysosome_physiology2.18264823
22MP0003453_abnormal_keratinocyte_physiol2.16197217
23MP0005000_abnormal_immune_tolerance2.04054009
24MP0002723_abnormal_immune_serum2.00049282
25MP0002420_abnormal_adaptive_immunity1.96326217
26MP0001819_abnormal_immune_cell1.89363987
27MP0001958_emphysema1.88918804
28MP0005310_abnormal_salivary_gland1.87854279
29MP0001835_abnormal_antigen_presentation1.87103584
30MP0003828_pulmonary_edema1.84393362
31MP0002452_abnormal_antigen_presenting1.82622381
32MP0002132_abnormal_respiratory_system1.74165945
33MP0001881_abnormal_mammary_gland1.70714777
34MP0002405_respiratory_system_inflammati1.68367363
35MP0003436_decreased_susceptibility_to1.56750054
36MP0005025_abnormal_response_to1.51726380
37MP0006276_abnormal_autonomic_nervous1.46916797
38MP0002419_abnormal_innate_immunity1.44811807
39MP0001851_eye_inflammation1.44698903
40MP0001502_abnormal_circadian_rhythm1.42997218
41MP0000716_abnormal_immune_system1.41595354
42MP0002277_abnormal_respiratory_mucosa1.38784034
43MP0002638_abnormal_pupillary_reflex1.35557350
44MP0002398_abnormal_bone_marrow1.35523359
45MP0000703_abnormal_thymus_morphology1.33770110
46MP0004947_skin_inflammation1.32082085
47MP0000689_abnormal_spleen_morphology1.30964154
48MP0000627_abnormal_mammary_gland1.30433154
49MP0003866_abnormal_defecation1.27920266
50MP0002148_abnormal_hypersensitivity_rea1.23092235
51MP0002722_abnormal_immune_system1.21651129
52MP0010155_abnormal_intestine_physiology1.18654036
53MP0009785_altered_susceptibility_to1.18588802
54MP0001845_abnormal_inflammatory_respons1.18037018
55MP0002429_abnormal_blood_cell1.17499177
56MP0003011_delayed_dark_adaptation1.16969133
57MP0005501_abnormal_skin_physiology1.14239521
58MP0001663_abnormal_digestive_system1.12276583
59MP0002933_joint_inflammation1.09050143
60MP0004270_analgesia1.06009545
61MP0004484_altered_response_of0.97478392
62MP0008469_abnormal_protein_level0.94759122
63MP0003448_altered_tumor_morphology0.93250052
64MP0002166_altered_tumor_susceptibility0.90516171
65MP0008874_decreased_physiological_sensi0.90343912
66MP0003136_yellow_coat_color0.89697371
67MP0001533_abnormal_skeleton_physiology0.85780711
68MP0009763_increased_sensitivity_to0.85595707
69MP0000609_abnormal_liver_physiology0.84855064
70MP0002970_abnormal_white_adipose0.84671865
71MP0002653_abnormal_ependyma_morphology0.79876500
72MP0000465_gastrointestinal_hemorrhage0.75688647
73MP0003936_abnormal_reproductive_system0.75645936
74MP0004742_abnormal_vestibular_system0.69578213
75MP0000015_abnormal_ear_pigmentation0.68003037
76MP0002971_abnormal_brown_adipose0.66577508
77MP0001984_abnormal_olfaction0.65791204
78MP0006036_abnormal_mitochondrial_physio0.63318449
79MP0002006_tumorigenesis0.63279613
80MP0002133_abnormal_respiratory_system0.62972330
81MP0005388_respiratory_system_phenotype0.62972330
82MP0001243_abnormal_dermal_layer0.62831968
83MP0000749_muscle_degeneration0.61848267
84MP0003878_abnormal_ear_physiology0.60409658
85MP0005377_hearing/vestibular/ear_phenot0.60409658
86MP0002098_abnormal_vibrissa_morphology0.59332710
87MP0005381_digestive/alimentary_phenotyp0.59265089
88MP0000604_amyloidosis0.58679395
89MP0002877_abnormal_melanocyte_morpholog0.57385622
90MP0003786_premature_aging0.55180576
91MP0002163_abnormal_gland_morphology0.53150635
92MP0000569_abnormal_digit_pigmentation0.51077864
93MP0006035_abnormal_mitochondrial_morpho0.48146057
94MP0001216_abnormal_epidermal_layer0.48009683
95MP0000858_altered_metastatic_potential0.47096167
96MP0000358_abnormal_cell_content/0.46029906
97MP0002396_abnormal_hematopoietic_system0.45147706
98MP0002693_abnormal_pancreas_physiology0.43402667
99MP0002136_abnormal_kidney_physiology0.43367438
100MP0005464_abnormal_platelet_physiology0.41289656

Predicted human phenotypes

RankGene SetZ-score
13-Methylglutaconic aciduria (HP:0003535)4.93722631
2Slow saccadic eye movements (HP:0000514)4.93445780
3Arthropathy (HP:0003040)4.53008748
4T lymphocytopenia (HP:0005403)4.46456023
5Mediastinal lymphadenopathy (HP:0100721)4.29734731
6Abnormality of T cell number (HP:0011839)3.97755078
7Anhidrosis (HP:0000970)3.85000828
8Oligodactyly (hands) (HP:0001180)3.80788611
9Genetic anticipation (HP:0003743)3.65256924
10Orthostatic hypotension (HP:0001278)3.56923259
11Abnormality of the labia minora (HP:0012880)3.56769709
12Autoamputation (HP:0001218)3.47499423
13Recurrent corneal erosions (HP:0000495)3.38714893
14Episodic fever (HP:0001954)3.36598109
15Increased CSF protein (HP:0002922)3.33361059
16Clitoromegaly (HP:0000057)3.32654858
17Stomatitis (HP:0010280)3.26128113
18Abnormality of oral frenula (HP:0000190)3.22710085
19Elevated erythrocyte sedimentation rate (HP:0003565)3.20105225
20Supernumerary bones of the axial skeleton (HP:0009144)3.10235236
21Abnormality of T cells (HP:0002843)3.06777095
22Acute encephalopathy (HP:0006846)3.03133368
23Peripheral hypomyelination (HP:0007182)2.99567450
24Dysmetric saccades (HP:0000641)2.98940281
25Bifid tongue (HP:0010297)2.98487407
26Molar tooth sign on MRI (HP:0002419)2.95950521
27Abnormality of midbrain morphology (HP:0002418)2.95950521
28Chorioretinal atrophy (HP:0000533)2.93101996
29Dysautonomia (HP:0002459)2.92572828
30Short tibia (HP:0005736)2.91361692
31Ectopic kidney (HP:0000086)2.88370040
32Myositis (HP:0100614)2.86406619
33Abnormality of dental color (HP:0011073)2.79277157
34Abnormality of saccadic eye movements (HP:0000570)2.71001676
35Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.69593890
36Pulmonary infiltrates (HP:0002113)2.69433036
37Aplasia/Hypoplasia of the tibia (HP:0005772)2.69232517
38Poor coordination (HP:0002370)2.68953431
39Volvulus (HP:0002580)2.68293430
40Tetraplegia (HP:0002445)2.66638487
41Chronic diarrhea (HP:0002028)2.64740842
42Segmental peripheral demyelination/remyelination (HP:0003481)2.58771906
43Scanning speech (HP:0002168)2.55918358
44Hemiplegia (HP:0002301)2.53962654
45Encephalitis (HP:0002383)2.52321288
46Recurrent cutaneous fungal infections (HP:0011370)2.50831966
47Chronic mucocutaneous candidiasis (HP:0002728)2.50831966
48Supernumerary ribs (HP:0005815)2.49134999
49Bile duct proliferation (HP:0001408)2.44587259
50Abnormal biliary tract physiology (HP:0012439)2.44587259
51Neonatal respiratory distress (HP:0002643)2.43435334
52Hypoplastic nipples (HP:0002557)2.41527652
53Keratitis (HP:0000491)2.41203954
54Abnormal delayed hypersensitivity skin test (HP:0002963)2.40372054
55Retrobulbar optic neuritis (HP:0100654)2.40345207
56Optic neuritis (HP:0100653)2.40345207
57Hypoproteinemia (HP:0003075)2.38395564
58Weak cry (HP:0001612)2.37025203
59Abnormality of DNA repair (HP:0003254)2.34221061
60IgM deficiency (HP:0002850)2.33950418
61Oligodactyly (HP:0012165)2.33815394
62Recurrent abscess formation (HP:0002722)2.30348004
63Progressive cerebellar ataxia (HP:0002073)2.27964339
64Abnormality of macrophages (HP:0004311)2.27695726
65Impaired vibratory sensation (HP:0002495)2.27668467
66Median cleft lip (HP:0000161)2.27025734
67Porencephaly (HP:0002132)2.24318943
68Albinism (HP:0001022)2.23910864
69Orchitis (HP:0100796)2.23903652
70Severe combined immunodeficiency (HP:0004430)2.23868851
71Hypotrichosis (HP:0001006)2.23618133
72Micronodular cirrhosis (HP:0001413)2.21488330
73Spastic paraparesis (HP:0002313)2.20875228
74Recurrent bacterial skin infections (HP:0005406)2.20841694
75Abnormality of secondary sexual hair (HP:0009888)2.19248000
76Abnormality of the axillary hair (HP:0100134)2.19248000
77Eczematoid dermatitis (HP:0000976)2.15421681
78Widely patent fontanelles and sutures (HP:0004492)2.14869605
79Recurrent fungal infections (HP:0002841)2.14200299
80IgG deficiency (HP:0004315)2.09390272
81Lymphopenia (HP:0001888)2.06395281
82Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.06233458
83Limb ataxia (HP:0002070)2.05024487
84Progressive muscle weakness (HP:0003323)2.03419201
85Abnormality of the clitoris (HP:0000056)2.02657007
86Tubular atrophy (HP:0000092)2.02175637
87Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.01896742
88Aplasia/Hypoplasia of the sternum (HP:0006714)2.00404241
89Inflammation of the large intestine (HP:0002037)1.97752996
90Self-mutilation (HP:0000742)1.96577065
91Meningitis (HP:0001287)1.95955973
92Conjunctival hamartoma (HP:0100780)1.95366517
93Impaired proprioception (HP:0010831)1.93591280
94Recurrent skin infections (HP:0001581)1.91296093
95Cortical visual impairment (HP:0100704)1.90588680
96Abnormality of the renal cortex (HP:0011035)1.88763481
97Abnormality of T cell physiology (HP:0011840)1.88025786
98Thyroid carcinoma (HP:0002890)1.86164570
99Abnormal autonomic nervous system physiology (HP:0012332)1.85915288
100Broad alveolar ridges (HP:0000187)1.83073631

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK15.75032217
2FES5.41159658
3MAP3K115.02455633
4TAOK24.80813208
5MAPKAPK34.65154064
6NTRK14.23485182
7NLK4.13014276
8MAP2K33.86688187
9MATK3.85233405
10MAP3K33.72493412
11MAP4K12.89203505
12CSK2.63022601
13MAP3K11.91467065
14MAP3K51.56372617
15ALK1.54356779
16TYRO31.50600135
17FER1.46710325
18TXK1.30764487
19ITK1.13006488
20DAPK11.06434713
21PINK10.94216123
22CSNK1G30.94134093
23LCK0.92872196
24CSNK1A1L0.91139158
25JAK30.86946716
26RIPK40.83686246
27HCK0.83670775
28TYK20.81186814
29ERBB20.80425950
30MARK30.80409115
31GRK60.79342277
32MAP4K20.78917171
33MAPKAPK20.74309240
34PASK0.73361385
35CSNK1G20.71648758
36PRKCQ0.71187595
37GRK70.71109844
38PHKG20.69273673
39PHKG10.69273673
40CSNK1G10.65847209
41MAP3K120.61983954
42BTK0.60694508
43LYN0.57870902
44PTK2B0.53972560
45STK100.50757402
46ERN10.50743628
47TLK10.50132515
48MAP3K80.48903997
49ZAP700.48761066
50EPHB10.48617759
51IRAK40.45369073
52SYK0.44520198
53MKNK20.43902234
54TNK20.43267063
55IKBKB0.41106015
56KIT0.39420614
57PRKD20.38018437
58ADRBK20.37976873
59INSR0.37757453
60TAOK30.37531384
61TGFBR20.37253316
62BLK0.37220825
63FGR0.35190478
64PDK10.34252527
65FYN0.34191666
66CASK0.32517613
67IKBKE0.30920862
68CAMKK10.30766837
69TEC0.29300240
70MAPK110.27402244
71JAK10.26708134
72JAK20.26438697
73PDK20.26037613
74PDGFRB0.25986210
75CSF1R0.25125815
76MAP3K140.24824115
77DMPK0.24681777
78MOS0.21444464
79MAP2K60.18855632
80BUB10.18686341
81RPS6KB10.16161337
82MAPK120.16040337
83SIK30.15147631
84GSK3A0.14167478
85NME10.14096029
86FGFR40.12548026
87CHUK0.10713157
88NUAK10.10306028
89IGF1R0.10189487
90PIM10.09765919
91CSNK2A10.08791351
92CHEK20.08738578
93TBK10.08728498
94CAMKK20.07483101
95PRKCH0.06691156
96NEK60.06252625
97GRK50.04874803
98PDPK10.04244201
99PTK60.03629388
100MARK20.02417984

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053323.93983502
2Allograft rejection_Homo sapiens_hsa053303.66961423
3Autoimmune thyroid disease_Homo sapiens_hsa053203.54195379
4Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046503.50819975
5Primary immunodeficiency_Homo sapiens_hsa053403.42859107
6Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.32983279
7One carbon pool by folate_Homo sapiens_hsa006703.06983933
8Type I diabetes mellitus_Homo sapiens_hsa049402.86719050
9Thyroid cancer_Homo sapiens_hsa052162.80675797
10T cell receptor signaling pathway_Homo sapiens_hsa046602.75937033
11Renal cell carcinoma_Homo sapiens_hsa052112.40877583
12Regulation of autophagy_Homo sapiens_hsa041402.39034691
13Antigen processing and presentation_Homo sapiens_hsa046122.22953001
14Malaria_Homo sapiens_hsa051442.06231134
15Chemical carcinogenesis_Homo sapiens_hsa052041.89418765
16Chemokine signaling pathway_Homo sapiens_hsa040621.85105836
17Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.83759499
18Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.73559677
19NF-kappa B signaling pathway_Homo sapiens_hsa040641.63998842
20Glycerophospholipid metabolism_Homo sapiens_hsa005641.63802202
21Measles_Homo sapiens_hsa051621.59402877
22Acute myeloid leukemia_Homo sapiens_hsa052211.58655013
23Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.56239906
24Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.52481886
25Osteoclast differentiation_Homo sapiens_hsa043801.45625613
26NOD-like receptor signaling pathway_Homo sapiens_hsa046211.43808928
27B cell receptor signaling pathway_Homo sapiens_hsa046621.42429842
28Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.31546017
29HIF-1 signaling pathway_Homo sapiens_hsa040661.28018825
30Cyanoamino acid metabolism_Homo sapiens_hsa004601.26823920
31Hematopoietic cell lineage_Homo sapiens_hsa046401.22137322
32Herpes simplex infection_Homo sapiens_hsa051681.21988789
33Apoptosis_Homo sapiens_hsa042101.20881599
34Staphylococcus aureus infection_Homo sapiens_hsa051501.20521739
35Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.19388511
36Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.13214663
37Caffeine metabolism_Homo sapiens_hsa002321.09890525
38TNF signaling pathway_Homo sapiens_hsa046681.06579433
39mRNA surveillance pathway_Homo sapiens_hsa030151.05916697
40MAPK signaling pathway_Homo sapiens_hsa040101.05071654
41Transcriptional misregulation in cancer_Homo sapiens_hsa052021.04101763
42Glycerolipid metabolism_Homo sapiens_hsa005611.04083431
43Viral myocarditis_Homo sapiens_hsa054161.02045926
44Linoleic acid metabolism_Homo sapiens_hsa005910.95525767
45RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.93712391
46Toxoplasmosis_Homo sapiens_hsa051450.91544002
47Jak-STAT signaling pathway_Homo sapiens_hsa046300.87790412
48Toll-like receptor signaling pathway_Homo sapiens_hsa046200.86238748
49Platelet activation_Homo sapiens_hsa046110.83265896
50alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.81816759
51Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.79512648
52HTLV-I infection_Homo sapiens_hsa051660.78049435
53Intestinal immune network for IgA production_Homo sapiens_hsa046720.74180975
54Leishmaniasis_Homo sapiens_hsa051400.72935989
55Hepatitis B_Homo sapiens_hsa051610.62551307
56Glycosaminoglycan degradation_Homo sapiens_hsa005310.60594935
57Proteasome_Homo sapiens_hsa030500.59361676
58Leukocyte transendothelial migration_Homo sapiens_hsa046700.58510744
59Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.56260096
60Epstein-Barr virus infection_Homo sapiens_hsa051690.56118335
61Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.54763959
62GnRH signaling pathway_Homo sapiens_hsa049120.53051816
63Arachidonic acid metabolism_Homo sapiens_hsa005900.45308479
64Spliceosome_Homo sapiens_hsa030400.44855835
65Colorectal cancer_Homo sapiens_hsa052100.44417836
66Endocytosis_Homo sapiens_hsa041440.42413849
67Purine metabolism_Homo sapiens_hsa002300.41205296
68Pathways in cancer_Homo sapiens_hsa052000.40944521
69Phospholipase D signaling pathway_Homo sapiens_hsa040720.40933968
70Ether lipid metabolism_Homo sapiens_hsa005650.39873437
71Tuberculosis_Homo sapiens_hsa051520.35625202
72Basal cell carcinoma_Homo sapiens_hsa052170.34265383
73cAMP signaling pathway_Homo sapiens_hsa040240.34246461
74Carbohydrate digestion and absorption_Homo sapiens_hsa049730.32875328
75Pancreatic secretion_Homo sapiens_hsa049720.32472675
76Nitrogen metabolism_Homo sapiens_hsa009100.32406926
77N-Glycan biosynthesis_Homo sapiens_hsa005100.31526699
78Olfactory transduction_Homo sapiens_hsa047400.31321960
79Choline metabolism in cancer_Homo sapiens_hsa052310.30288347
80Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.30190980
81Influenza A_Homo sapiens_hsa051640.28169492
82Endometrial cancer_Homo sapiens_hsa052130.27941196
83Circadian rhythm_Homo sapiens_hsa047100.26770953
84Neurotrophin signaling pathway_Homo sapiens_hsa047220.26666256
85Dorso-ventral axis formation_Homo sapiens_hsa043200.26089490
86Adherens junction_Homo sapiens_hsa045200.26046083
87Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.25668762
88Mineral absorption_Homo sapiens_hsa049780.23186009
89RNA polymerase_Homo sapiens_hsa030200.22666037
90Histidine metabolism_Homo sapiens_hsa003400.21718086
91Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.21019646
92Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.20829051
93Morphine addiction_Homo sapiens_hsa050320.20196805
94Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.19119202
95Lysosome_Homo sapiens_hsa041420.17115569
96Viral carcinogenesis_Homo sapiens_hsa052030.16780733
97Sphingolipid signaling pathway_Homo sapiens_hsa040710.16259451
98Fat digestion and absorption_Homo sapiens_hsa049750.16058486
99Ras signaling pathway_Homo sapiens_hsa040140.15040136
100Legionellosis_Homo sapiens_hsa051340.14218175

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