TRBV10-3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative T cell selection (GO:0043383)6.89729257
2tolerance induction (GO:0002507)6.84771116
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.68721611
4negative regulation of cell killing (GO:0031342)6.68721611
5negative thymic T cell selection (GO:0045060)6.63228413
6positive regulation of gamma-delta T cell activation (GO:0046645)6.47110431
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.44356579
8positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)6.38519009
9regulation of regulatory T cell differentiation (GO:0045589)6.32327829
10antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.95401975
11regulation of T cell tolerance induction (GO:0002664)5.87076264
12response to interleukin-15 (GO:0070672)5.72267305
13regulation of isotype switching to IgG isotypes (GO:0048302)5.68253287
14cellular response to interleukin-15 (GO:0071350)5.47236047
15thymic T cell selection (GO:0045061)5.46823904
16positive regulation of interleukin-2 biosynthetic process (GO:0045086)5.44990904
17antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.42563478
18antigen processing and presentation of endogenous antigen (GO:0019883)5.36140294
19positive regulation of tolerance induction (GO:0002645)5.32511882
20T cell selection (GO:0045058)5.30717295
21positive T cell selection (GO:0043368)5.27389284
22regulation of gamma-delta T cell differentiation (GO:0045586)5.23101181
23regulation of B cell receptor signaling pathway (GO:0050855)5.17905697
24regulation of tolerance induction (GO:0002643)4.93526839
25positive thymic T cell selection (GO:0045059)4.89673180
26regulation of gamma-delta T cell activation (GO:0046643)4.85026489
27activated T cell proliferation (GO:0050798)4.69791648
28negative regulation of T cell mediated immunity (GO:0002710)4.69698818
29T cell migration (GO:0072678)4.66154423
30leukocyte aggregation (GO:0070486)4.51141730
31regulation of interleukin-2 biosynthetic process (GO:0045076)4.49489343
32regulation of alpha-beta T cell proliferation (GO:0046640)4.40811571
33negative regulation of lymphocyte mediated immunity (GO:0002707)4.25529779
34T cell receptor signaling pathway (GO:0050852)4.16693896
35positive regulation of granulocyte differentiation (GO:0030854)4.04255571
36T cell homeostasis (GO:0043029)3.89652346
37regulation of B cell differentiation (GO:0045577)3.84323937
38antigen receptor-mediated signaling pathway (GO:0050851)3.80855556
39regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.75040914
40negative regulation of leukocyte mediated immunity (GO:0002704)3.71800732
41regulation of T cell mediated cytotoxicity (GO:0001914)3.70382194
42positive regulation of T cell mediated cytotoxicity (GO:0001916)3.68250926
43alpha-beta T cell differentiation (GO:0046632)3.64196182
44positive regulation of alpha-beta T cell proliferation (GO:0046641)3.63238028
45regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.58824240
46regulation of natural killer cell mediated immunity (GO:0002715)3.58824240
47positive regulation of T cell differentiation in thymus (GO:0033089)3.58706181
48positive regulation of interleukin-4 production (GO:0032753)3.57728732
49interferon-gamma production (GO:0032609)3.55736600
50Peyers patch development (GO:0048541)3.51087585
51mucosal-associated lymphoid tissue development (GO:0048537)3.51087585
52positive regulation of isotype switching (GO:0045830)3.48661256
53regulation of isotype switching (GO:0045191)3.46263895
54positive regulation of interleukin-2 production (GO:0032743)3.46141615
55positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.44236036
56positive regulation of B cell differentiation (GO:0045579)3.42507061
57antigen processing and presentation via MHC class Ib (GO:0002475)3.39599374
58alpha-beta T cell activation (GO:0046631)3.35714175
59detection of bacterium (GO:0016045)3.34580512
60NIK/NF-kappaB signaling (GO:0038061)3.30981298
61mast cell activation (GO:0045576)3.27274237
62positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.24097141
63regulation of leukocyte mediated cytotoxicity (GO:0001910)3.23404396
64regulation of alpha-beta T cell activation (GO:0046634)3.23147737
65detection of other organism (GO:0098543)3.22028865
66T cell costimulation (GO:0031295)3.21924915
67positive regulation of macrophage differentiation (GO:0045651)3.21677089
68myeloid dendritic cell differentiation (GO:0043011)3.21628012
69modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.21251304
70positive regulation by organism of defense response of other organism involved in symbiotic interact3.21251304
71modulation by symbiont of host immune response (GO:0052553)3.21251304
72positive regulation by symbiont of host defense response (GO:0052509)3.21251304
73modulation by symbiont of host defense response (GO:0052031)3.21251304
74modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.21251304
75regulation of T cell receptor signaling pathway (GO:0050856)3.20182793
76positive regulation of interleukin-17 production (GO:0032740)3.17893102
77lymphocyte costimulation (GO:0031294)3.17458450
78regulation of interleukin-4 production (GO:0032673)3.17286515
79T cell differentiation (GO:0030217)3.17029098
80type I interferon signaling pathway (GO:0060337)3.13538940
81cellular response to type I interferon (GO:0071357)3.13538940
82lymphocyte homeostasis (GO:0002260)3.11882791
83CD4-positive, alpha-beta T cell differentiation (GO:0043367)3.11540411
84response to type I interferon (GO:0034340)3.11367700
85positive regulation of DNA recombination (GO:0045911)3.10511001
86positive regulation of T cell mediated immunity (GO:0002711)3.10277396
87positive regulation of humoral immune response (GO:0002922)3.09452691
88natural killer cell differentiation (GO:0001779)3.08964737
89B cell receptor signaling pathway (GO:0050853)3.06823527
90lymphocyte migration (GO:0072676)3.06732512
91myeloid dendritic cell activation (GO:0001773)3.03428158
92negative regulation of interleukin-12 production (GO:0032695)3.03393347
93regulation of T cell mediated immunity (GO:0002709)3.02398243
94negative regulation of cytokine production involved in immune response (GO:0002719)3.02076993
95regulation of defense response to virus by virus (GO:0050690)3.01876062
96negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.01174568
97negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.98689360
98positive regulation of cell killing (GO:0031343)2.98541745
99positive regulation of alpha-beta T cell activation (GO:0046635)2.97140516
100regulation of cell killing (GO:0031341)2.96253075

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse6.51275872
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human6.37122599
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.42547405
4BP1_19119308_ChIP-ChIP_Hs578T_Human4.18333834
5RUNX_20019798_ChIP-Seq_JUKART_Human3.85087137
6MYB_26560356_Chip-Seq_TH2_Human3.38221644
7STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.38007298
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.36595035
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.20403112
10STAT4_19710469_ChIP-ChIP_TH1__Mouse2.99927187
11FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.98005630
12MAF_26560356_Chip-Seq_TH1_Human2.97366579
13MYC_22102868_ChIP-Seq_BL_Human2.94018120
14IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.93711762
15SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.88545664
16IRF8_21731497_ChIP-ChIP_J774_Mouse2.86549482
17ELF1_17652178_ChIP-ChIP_JURKAT_Human2.76808512
18MYB_26560356_Chip-Seq_TH1_Human2.70178792
19UTX_26944678_Chip-Seq_JUKART_Human2.69225956
20SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.48663363
21RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.37768068
22MAF_26560356_Chip-Seq_TH2_Human2.37572583
23SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.35934418
24SPI1_23547873_ChIP-Seq_NB4_Human2.27521864
25VDR_21846776_ChIP-Seq_THP-1_Human2.25680987
26GATA3_27048872_Chip-Seq_THYMUS_Human2.21587352
27NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.19623477
28IRF8_27001747_Chip-Seq_BMDM_Mouse2.10085484
29MYB_21317192_ChIP-Seq_ERMYB_Mouse2.09971548
30RUNX1_22412390_ChIP-Seq_EML_Mouse2.09025001
31E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.05754942
32TCF7_22412390_ChIP-Seq_EML_Mouse1.98104055
33SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.96909785
34NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.96244503
35KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.92855516
36VDR_24763502_ChIP-Seq_THP-1_Human1.92591916
37SCL_19346495_ChIP-Seq_HPC-7_Human1.89128776
38BRD4_27068464_Chip-Seq_AML-cells_Mouse1.79010874
39SMAD_19615063_ChIP-ChIP_OVARY_Human1.78740084
40KDM2B_26808549_Chip-Seq_DND41_Human1.76872111
41KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.74499964
42MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.73714003
43FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.69102451
44SPI1_23127762_ChIP-Seq_K562_Human1.67191906
45KDM2B_26808549_Chip-Seq_SUP-B15_Human1.65772740
46GATA3_26560356_Chip-Seq_TH2_Human1.60651279
47ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.58443930
48VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.55760560
49NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.47589976
50CIITA_25753668_ChIP-Seq_RAJI_Human1.46197398
51KDM2B_26808549_Chip-Seq_JURKAT_Human1.43949996
52RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.43102152
53RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.40818595
54EGR1_19374776_ChIP-ChIP_THP-1_Human1.38586610
55SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.37283908
56TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.34522794
57TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.31658904
58NOTCH1_21737748_ChIP-Seq_TLL_Human1.29843443
59LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.26337322
60TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25635650
61GATA2_22383799_ChIP-Seq_G1ME_Mouse1.25628623
62STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.25465055
63CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.21832882
64ELK3_25401928_ChIP-Seq_HUVEC_Human1.21732125
65PU_27001747_Chip-Seq_BMDM_Mouse1.16360651
66LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.15769884
67CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.13130517
68GATA1_22383799_ChIP-Seq_G1ME_Mouse1.13075077
69CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11030868
70PU.1_20513432_ChIP-Seq_Bcells_Mouse1.10341001
71PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08927952
72CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06999833
73PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05270287
74FOXP3_21729870_ChIP-Seq_TREG_Human1.02997236
75VDR_23849224_ChIP-Seq_CD4+_Human0.99764324
76GATA1_19941827_ChIP-Seq_MEL_Mouse0.98124166
77SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97269400
78GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.96755969
79BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.95691072
80THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.94960975
81VDR_24787735_ChIP-Seq_THP-1_Human0.94789903
82Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.92072999
83RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91876849
84NCOR1_26117541_ChIP-Seq_K562_Human0.91449590
85PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.90860757
86GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88040535
87CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.87579673
88BCL6_27268052_Chip-Seq_Bcells_Human0.87037427
89HOXB4_20404135_ChIP-ChIP_EML_Mouse0.86676721
90FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82024004
91GATA1_19941826_ChIP-Seq_K562_Human0.80200311
92CTCF_27219007_Chip-Seq_ERYTHROID_Human0.79502133
93GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.79285104
94PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.79003640
95ELF1_20517297_ChIP-Seq_JURKAT_Human0.77767275
96BCOR_27268052_Chip-Seq_Bcells_Human0.77130248
97LXR_22292898_ChIP-Seq_THP-1_Human0.76075304
98GATA3_26560356_Chip-Seq_TH1_Human0.74001147
99EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.73712335
100CTCF_21964334_ChIP-Seq_BJAB-B_Human0.66719120

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology5.35869984
2MP0005671_abnormal_response_to4.32949141
3MP0003436_decreased_susceptibility_to3.93842455
4MP0001835_abnormal_antigen_presentation3.53298242
5MP0001873_stomach_inflammation3.35809612
6MP0009333_abnormal_splenocyte_physiolog3.28345193
7MP0005000_abnormal_immune_tolerance3.19843047
8MP0001800_abnormal_humoral_immune3.17835550
9MP0005387_immune_system_phenotype3.09753806
10MP0001790_abnormal_immune_system3.09753806
11MP0003300_gastrointestinal_ulcer3.06527095
12MP0003724_increased_susceptibility_to2.93737493
13MP0000685_abnormal_immune_system2.83563672
14MP0002420_abnormal_adaptive_immunity2.74852790
15MP0001819_abnormal_immune_cell2.70744991
16MP0002723_abnormal_immune_serum2.69713083
17MP0000703_abnormal_thymus_morphology2.62956496
18MP0003866_abnormal_defecation2.61121166
19MP0002405_respiratory_system_inflammati2.54649156
20MP0005025_abnormal_response_to2.54392057
21MP0000465_gastrointestinal_hemorrhage2.52245112
22MP0002398_abnormal_bone_marrow2.48554368
23MP0002148_abnormal_hypersensitivity_rea2.44275594
24MP0002452_abnormal_antigen_presenting2.42747834
25MP0006082_CNS_inflammation2.40982708
26MP0009785_altered_susceptibility_to2.34600138
27MP0010155_abnormal_intestine_physiology2.30854820
28MP0002419_abnormal_innate_immunity2.28370974
29MP0000716_abnormal_immune_system2.23752404
30MP0004381_abnormal_hair_follicle2.12041582
31MP0002722_abnormal_immune_system2.05169639
32MP0004947_skin_inflammation1.99283872
33MP0003303_peritoneal_inflammation1.98404233
34MP0000689_abnormal_spleen_morphology1.95263238
35MP0002277_abnormal_respiratory_mucosa1.92151904
36MP0001348_abnormal_lacrimal_gland1.77970648
37MP0002429_abnormal_blood_cell1.76180516
38MP0005310_abnormal_salivary_gland1.76066688
39MP0005464_abnormal_platelet_physiology1.74396240
40MP0001853_heart_inflammation1.74036122
41MP0001845_abnormal_inflammatory_respons1.66760510
42MP0001533_abnormal_skeleton_physiology1.57248531
43MP0002166_altered_tumor_susceptibility1.53575118
44MP0001851_eye_inflammation1.53204082
45MP0002396_abnormal_hematopoietic_system1.50263396
46MP0005075_abnormal_melanosome_morpholog1.43058472
47MP0002933_joint_inflammation1.34124400
48MP0000490_abnormal_crypts_of1.33104647
49MP0002132_abnormal_respiratory_system1.30566476
50MP0008260_abnormal_autophagy1.18627035
51MP0008469_abnormal_protein_level1.13253949
52MP0002163_abnormal_gland_morphology1.04990997
53MP0002009_preneoplasia1.02981863
54MP0000858_altered_metastatic_potential0.98316681
55MP0002006_tumorigenesis0.96062499
56MP0002998_abnormal_bone_remodeling0.94519587
57MP0000604_amyloidosis0.93885713
58MP0001663_abnormal_digestive_system0.91462061
59MP0002138_abnormal_hepatobiliary_system0.87755061
60MP0005451_abnormal_body_composition0.86694730
61MP0009278_abnormal_bone_marrow0.83422037
62MP0004808_abnormal_hematopoietic_stem0.81604188
63MP0002019_abnormal_tumor_incidence0.78345824
64MP0003172_abnormal_lysosome_physiology0.78193311
65MP0003045_fibrosis0.74283325
66MP0003191_abnormal_cellular_cholesterol0.72807139
67MP0002254_reproductive_system_inflammat0.72674040
68MP0009763_increased_sensitivity_to0.69977453
69MP0009764_decreased_sensitivity_to0.68232854
70MP0002693_abnormal_pancreas_physiology0.67319731
71MP0003448_altered_tumor_morphology0.67258497
72MP0003828_pulmonary_edema0.65618953
73MP0008569_lethality_at_weaning0.64795367
74MP0004510_myositis0.63293194
75MP0008961_abnormal_basal_metabolism0.60838856
76MP0005390_skeleton_phenotype0.56179383
77MP0001919_abnormal_reproductive_system0.56123261
78MP0005166_decreased_susceptibility_to0.52703856
79MP0003795_abnormal_bone_structure0.51769515
80MP0004130_abnormal_muscle_cell0.51696180
81MP0001346_abnormal_lacrimal_gland0.51294480
82MP0004883_abnormal_blood_vessel0.49610812
83MP0000249_abnormal_blood_vessel0.49371838
84MP0000609_abnormal_liver_physiology0.48426380
85MP0003786_premature_aging0.48181856
86MP0005381_digestive/alimentary_phenotyp0.47456445
87MP0003091_abnormal_cell_migration0.45793365
88MP0008004_abnormal_stomach_pH0.43889194
89MP0009765_abnormal_xenobiotic_induced0.40936650
90MP0000920_abnormal_myelination0.40468858
91MP0000015_abnormal_ear_pigmentation0.39477162
92MP0000477_abnormal_intestine_morphology0.38992392
93MP0008873_increased_physiological_sensi0.38080603
94MP0005379_endocrine/exocrine_gland_phen0.34138846
95MP0001986_abnormal_taste_sensitivity0.33366271
96MP0003075_altered_response_to0.31909408
97MP0001502_abnormal_circadian_rhythm0.31222602
98MP0001765_abnormal_ion_homeostasis0.30919310
99MP0008874_decreased_physiological_sensi0.30792552
100MP0002083_premature_death0.29269450

Predicted human phenotypes

RankGene SetZ-score
1Autoimmune hemolytic anemia (HP:0001890)6.54430913
2Stomatitis (HP:0010280)6.43628548
3Elevated erythrocyte sedimentation rate (HP:0003565)5.96991253
4Eczematoid dermatitis (HP:0000976)5.84145408
5T lymphocytopenia (HP:0005403)5.73271170
6Abnormality of T cell number (HP:0011839)5.41353074
7Myositis (HP:0100614)4.72850848
8Abnormality of T cells (HP:0002843)4.72380078
9Abnormal delayed hypersensitivity skin test (HP:0002963)4.56333725
10Recurrent fungal infections (HP:0002841)4.28100589
11Severe combined immunodeficiency (HP:0004430)4.21004576
12Gastrointestinal infarctions (HP:0005244)4.19152600
13Recurrent abscess formation (HP:0002722)4.09761176
14Recurrent bacterial skin infections (HP:0005406)4.09399795
15Orchitis (HP:0100796)3.85992056
16Abnormality of macrophages (HP:0004311)3.84732397
17Abnormality of T cell physiology (HP:0011840)3.84674192
18Vasculitis (HP:0002633)3.82044644
19Retrobulbar optic neuritis (HP:0100654)3.78770916
20Optic neuritis (HP:0100653)3.78770916
21Panhypogammaglobulinemia (HP:0003139)3.75803557
22Meningitis (HP:0001287)3.71998455
23Obstructive lung disease (HP:0006536)3.70469297
24Chronic obstructive pulmonary disease (HP:0006510)3.70469297
25IgG deficiency (HP:0004315)3.69380958
26Lymphopenia (HP:0001888)3.67212735
27Pustule (HP:0200039)3.66690068
28Mediastinal lymphadenopathy (HP:0100721)3.64410907
29Increased IgM level (HP:0003496)3.60786680
30Granulocytopenia (HP:0001913)3.60020025
31Recurrent viral infections (HP:0004429)3.57280379
32Chronic mucocutaneous candidiasis (HP:0002728)3.55939144
33Recurrent cutaneous fungal infections (HP:0011370)3.55939144
34Encephalitis (HP:0002383)3.47824749
35Abnormality of cells of the lymphoid lineage (HP:0012140)3.47088593
36Abnormality of eosinophils (HP:0001879)3.41834785
37Spontaneous hematomas (HP:0007420)3.41530497
38Leukocytosis (HP:0001974)3.34203086
39Combined immunodeficiency (HP:0005387)3.31043572
40Autoimmune thrombocytopenia (HP:0001973)3.30771354
41Eosinophilia (HP:0001880)3.29809707
42IgM deficiency (HP:0002850)3.26370364
43Increased IgE level (HP:0003212)3.25716041
44Pulmonary infiltrates (HP:0002113)3.22090221
45Chest pain (HP:0100749)3.21368804
46Recurrent skin infections (HP:0001581)3.12792506
47Recurrent bronchitis (HP:0002837)3.05556045
48Chronic diarrhea (HP:0002028)2.96902468
49Hypochromic anemia (HP:0001931)2.93014360
50Prolonged bleeding time (HP:0003010)2.89561243
51Hypochromic microcytic anemia (HP:0004840)2.86091190
52Keratoconjunctivitis (HP:0001096)2.83349009
53Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.82694090
54Recurrent gram-negative bacterial infections (HP:0005420)2.80631341
55Keratoconjunctivitis sicca (HP:0001097)2.79554509
56Hemoptysis (HP:0002105)2.74976834
57Increased neuronal autofluorescent lipopigment (HP:0002074)2.63232753
58Lymphoma (HP:0002665)2.61120368
59Verrucae (HP:0200043)2.58821231
60Papilloma (HP:0012740)2.58821231
61Joint swelling (HP:0001386)2.57352367
62Inflammation of the large intestine (HP:0002037)2.57307068
63Pulmonary embolism (HP:0002204)2.57012853
64Gastrointestinal inflammation (HP:0004386)2.55476272
65Epistaxis (HP:0000421)2.54643196
66Papilledema (HP:0001085)2.50511658
67Increased cerebral lipofuscin (HP:0011813)2.50036208
68Gingivitis (HP:0000230)2.47771168
69Agammaglobulinemia (HP:0004432)2.46453985
70Hypergammaglobulinemia (HP:0010702)2.44496065
71Basal cell carcinoma (HP:0002671)2.44315023
72Urticaria (HP:0001025)2.42774357
73Hypoplasia of the thymus (HP:0000778)2.36604207
74Abnormality of the prostate (HP:0008775)2.36320241
75Gangrene (HP:0100758)2.34266029
76Anorexia (HP:0002039)2.25852715
77Slow saccadic eye movements (HP:0000514)2.21874665
78Thyroiditis (HP:0100646)2.17371325
79Alveolar cell carcinoma (HP:0006519)2.16138271
80Microcytic anemia (HP:0001935)2.14425596
81Abnormality of the pleura (HP:0002103)2.12922017
82Sepsis (HP:0100806)2.11157487
83Petechiae (HP:0000967)2.10818229
84Cellulitis (HP:0100658)2.02913977
85Glomerulopathy (HP:0100820)2.02898631
86Arterial thrombosis (HP:0004420)2.00023239
87Acute hepatic failure (HP:0006554)1.98561265
88Neoplasm of the tracheobronchial system (HP:0100552)1.98256586
89Gingival bleeding (HP:0000225)1.95458808
90Colitis (HP:0002583)1.93896513
91Segmental peripheral demyelination/remyelination (HP:0003481)1.91776408
92Abnormality of B cell number (HP:0010975)1.91773412
93Episodic fever (HP:0001954)1.89260208
94Aplasia/Hypoplasia of the thymus (HP:0010515)1.88552637
95B lymphocytopenia (HP:0010976)1.88360104
96Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.87945052
97Skin ulcer (HP:0200042)1.86418474
98Amaurosis fugax (HP:0100576)1.84204634
99Skin rash (HP:0000988)1.80238156
100Purpura (HP:0000979)1.78479015

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.71169361
2TXK5.63517321
3ITK2.91169727
4ZAP702.64941226
5RIPK42.61139436
6FES2.56858986
7PRPF4B2.52150273
8CSK2.46553300
9BTK2.34862092
10GRK62.22296144
11PASK2.21513108
12TYK22.16171136
13JAK31.98971372
14SIK31.95444690
15LCK1.91064875
16TNK21.89717756
17IRAK41.82850570
18IKBKE1.76222549
19HCK1.70779337
20NLK1.68598325
21SYK1.64004219
22MAP3K131.63063467
23EPHB11.58217613
24TEC1.57388523
25CAMKK21.57063160
26CAMKK11.55957568
27FGFR41.50355805
28MAP3K141.45390790
29ERN11.44857369
30JAK11.43758018
31MARK31.42626056
32MAP2K31.38633960
33MAP3K111.34161709
34TBK11.32097667
35LYN1.26743581
36SIK21.24181219
37BLK1.19565174
38TAOK31.16516311
39IKBKB1.12703896
40PRKCQ1.11127069
41MAP3K11.08888867
42JAK21.08268526
43MAP3K31.06396450
44FGFR31.01256527
45MAP3K100.95248461
46STK100.91631966
47TYRO30.90171503
48TAOK10.88832018
49KDR0.84071213
50MAPK120.82666394
51PDK10.77392300
52HIPK20.76556822
53CDK120.74502095
54LRRK20.74436378
55TAOK20.74140684
56SMG10.73771090
57CSF1R0.71567180
58FYN0.71085704
59TESK20.70917244
60EPHA30.69860997
61PTK60.66779992
62SIK10.65002331
63MAPK110.63988204
64MARK20.63822029
65CDK40.62195147
66PIM10.62122755
67MAP3K70.60687872
68TRIB30.59660632
69PRKD20.58961170
70YES10.55453266
71KSR20.54577231
72PRKCH0.53148229
73PDGFRB0.52246704
74FGR0.52183411
75MAPK70.51589732
76BMPR20.50279634
77IRAK10.41829531
78CDK60.40194407
79STK380.38657128
80CDK190.38363187
81RET0.38109497
82CLK10.36180524
83DYRK1B0.35015742
84MAP2K60.34331090
85NEK60.33987364
86PKN20.33386413
87PDPK10.31534366
88MAPKAPK20.31359517
89UHMK10.29383086
90MAPK30.27398699
91NTRK20.27113645
92SGK30.26439847
93BRD40.25971913
94RPS6KB10.24546192
95FGFR10.23909290
96MELK0.23516318
97INSR0.23436393
98CHUK0.23064855
99IRAK20.21168386
100EGFR0.19326360

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.42734204
2T cell receptor signaling pathway_Homo sapiens_hsa046603.69685865
3Autoimmune thyroid disease_Homo sapiens_hsa053202.90343445
4Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.89637355
5Graft-versus-host disease_Homo sapiens_hsa053322.84304017
6Allograft rejection_Homo sapiens_hsa053302.81616965
7Measles_Homo sapiens_hsa051622.65560027
8Osteoclast differentiation_Homo sapiens_hsa043802.42325826
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.35947040
10NF-kappa B signaling pathway_Homo sapiens_hsa040642.19685276
11Hematopoietic cell lineage_Homo sapiens_hsa046402.11723549
12Type I diabetes mellitus_Homo sapiens_hsa049402.06103870
13Acute myeloid leukemia_Homo sapiens_hsa052212.00947508
14B cell receptor signaling pathway_Homo sapiens_hsa046621.93125095
15Antigen processing and presentation_Homo sapiens_hsa046121.92969185
16RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.82946939
17Toll-like receptor signaling pathway_Homo sapiens_hsa046201.81810646
18Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.81238954
19Leishmaniasis_Homo sapiens_hsa051401.73392115
20Jak-STAT signaling pathway_Homo sapiens_hsa046301.72796263
21Chemokine signaling pathway_Homo sapiens_hsa040621.68913134
22Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.56343936
23Herpes simplex infection_Homo sapiens_hsa051681.53461320
24Viral myocarditis_Homo sapiens_hsa054161.53197969
25NOD-like receptor signaling pathway_Homo sapiens_hsa046211.46012714
26Intestinal immune network for IgA production_Homo sapiens_hsa046721.44504757
27Non-small cell lung cancer_Homo sapiens_hsa052231.42602255
28Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.42254277
29Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.42180670
30TNF signaling pathway_Homo sapiens_hsa046681.41512664
31Hepatitis B_Homo sapiens_hsa051611.31867807
32Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.25357497
33Tuberculosis_Homo sapiens_hsa051521.16160005
34Malaria_Homo sapiens_hsa051441.15433947
35Staphylococcus aureus infection_Homo sapiens_hsa051501.15346831
36VEGF signaling pathway_Homo sapiens_hsa043701.14361634
37Chronic myeloid leukemia_Homo sapiens_hsa052201.12483754
38Toxoplasmosis_Homo sapiens_hsa051451.10937833
39Viral carcinogenesis_Homo sapiens_hsa052031.10689078
40HTLV-I infection_Homo sapiens_hsa051661.10204698
41Influenza A_Homo sapiens_hsa051641.08802580
42Leukocyte transendothelial migration_Homo sapiens_hsa046701.06388352
43Apoptosis_Homo sapiens_hsa042101.03882575
44Pancreatic cancer_Homo sapiens_hsa052121.03169676
45Colorectal cancer_Homo sapiens_hsa052100.98774301
46Platelet activation_Homo sapiens_hsa046110.96876669
47Epstein-Barr virus infection_Homo sapiens_hsa051690.92813834
48Hepatitis C_Homo sapiens_hsa051600.92385714
49Shigellosis_Homo sapiens_hsa051310.87162996
50Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.86713832
51Legionellosis_Homo sapiens_hsa051340.86524603
52Renal cell carcinoma_Homo sapiens_hsa052110.85804040
53African trypanosomiasis_Homo sapiens_hsa051430.84828630
54SNARE interactions in vesicular transport_Homo sapiens_hsa041300.84713706
55Endometrial cancer_Homo sapiens_hsa052130.84409659
56Asthma_Homo sapiens_hsa053100.83705641
57Prolactin signaling pathway_Homo sapiens_hsa049170.83383511
58FoxO signaling pathway_Homo sapiens_hsa040680.82503755
59Rheumatoid arthritis_Homo sapiens_hsa053230.79793436
60Phosphatidylinositol signaling system_Homo sapiens_hsa040700.76422122
61Salmonella infection_Homo sapiens_hsa051320.74863241
62AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.74703199
63Endocytosis_Homo sapiens_hsa041440.71840324
64Neurotrophin signaling pathway_Homo sapiens_hsa047220.71188805
65Thyroid cancer_Homo sapiens_hsa052160.70192517
66Pertussis_Homo sapiens_hsa051330.60031656
67mTOR signaling pathway_Homo sapiens_hsa041500.59849894
68MAPK signaling pathway_Homo sapiens_hsa040100.58717637
69Sphingolipid signaling pathway_Homo sapiens_hsa040710.55741318
70Regulation of autophagy_Homo sapiens_hsa041400.55513283
71Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.54492484
72Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.53038428
73Prostate cancer_Homo sapiens_hsa052150.51993702
74HIF-1 signaling pathway_Homo sapiens_hsa040660.51705216
75Long-term potentiation_Homo sapiens_hsa047200.50763678
76Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.50698096
77Inositol phosphate metabolism_Homo sapiens_hsa005620.49124778
78Choline metabolism in cancer_Homo sapiens_hsa052310.47991211
79Notch signaling pathway_Homo sapiens_hsa043300.47363896
80Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.46127135
81Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.45163939
82Transcriptional misregulation in cancer_Homo sapiens_hsa052020.43888027
83ErbB signaling pathway_Homo sapiens_hsa040120.43659833
84Phospholipase D signaling pathway_Homo sapiens_hsa040720.40304051
85Phagosome_Homo sapiens_hsa041450.38380738
86Ribosome_Homo sapiens_hsa030100.38201252
87Adipocytokine signaling pathway_Homo sapiens_hsa049200.37214073
88Carbohydrate digestion and absorption_Homo sapiens_hsa049730.37024295
89Insulin resistance_Homo sapiens_hsa049310.36241321
90Rap1 signaling pathway_Homo sapiens_hsa040150.35431394
91Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.34154237
92Ras signaling pathway_Homo sapiens_hsa040140.32978247
93Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.32886029
94Glioma_Homo sapiens_hsa052140.32282234
95Other glycan degradation_Homo sapiens_hsa005110.30491454
96Insulin signaling pathway_Homo sapiens_hsa049100.29600499
97Dorso-ventral axis formation_Homo sapiens_hsa043200.27259272
98Spliceosome_Homo sapiens_hsa030400.26948062
99GnRH signaling pathway_Homo sapiens_hsa049120.26747689
100Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.24782906

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