TRBV11-1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular response to interleukin-15 (GO:0071350)6.65692995
2response to interleukin-15 (GO:0070672)6.28747918
3regulation of isotype switching to IgG isotypes (GO:0048302)6.16758041
4positive regulation of gamma-delta T cell activation (GO:0046645)5.82061489
5negative T cell selection (GO:0043383)5.77185317
6antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.55224342
7negative thymic T cell selection (GO:0045060)5.50958719
8negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.43891772
9negative regulation of cell killing (GO:0031342)5.43891772
10tolerance induction (GO:0002507)5.27242867
11antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.20383768
12antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.14626561
13positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.10933925
14positive regulation of granulocyte differentiation (GO:0030854)5.09066707
15antigen processing and presentation of endogenous antigen (GO:0019883)4.95807197
16T cell differentiation involved in immune response (GO:0002292)4.91192208
17alpha-beta T cell differentiation involved in immune response (GO:0002293)4.91192208
18alpha-beta T cell activation involved in immune response (GO:0002287)4.91192208
19regulation of interleukin-12 biosynthetic process (GO:0045075)4.89255951
20regulation of gamma-delta T cell differentiation (GO:0045586)4.77733672
21activated T cell proliferation (GO:0050798)4.66016557
22regulation of regulatory T cell differentiation (GO:0045589)4.65948039
23thymic T cell selection (GO:0045061)4.65757820
24mast cell activation involved in immune response (GO:0002279)4.63269511
25mast cell degranulation (GO:0043303)4.63269511
26alpha-beta T cell differentiation (GO:0046632)4.59647268
27mast cell activation (GO:0045576)4.59004067
28T cell selection (GO:0045058)4.57197237
29regulation of gamma-delta T cell activation (GO:0046643)4.48057851
30positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.37167104
31negative regulation of metanephros development (GO:0072217)4.31527563
32positive T cell selection (GO:0043368)4.23287011
33leukocyte aggregation (GO:0070486)4.22618053
34regulation of B cell receptor signaling pathway (GO:0050855)4.17932279
35positive regulation of isotype switching (GO:0045830)4.15464219
36regulation of podosome assembly (GO:0071801)4.07688190
37alpha-beta T cell activation (GO:0046631)4.04353350
38regulation of granulocyte differentiation (GO:0030852)4.01258132
39negative regulation of interleukin-17 production (GO:0032700)4.00628574
40myeloid dendritic cell differentiation (GO:0043011)3.96350039
41positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.95389378
42regulation of T cell tolerance induction (GO:0002664)3.93533396
43regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033393.85739256
44negative regulation of T cell mediated immunity (GO:0002710)3.83520515
45T cell homeostasis (GO:0043029)3.83133199
46regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)3.79953822
47positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)3.79953822
48T cell migration (GO:0072678)3.77291682
49negative regulation of phagocytosis (GO:0050765)3.73990390
50defense response to protozoan (GO:0042832)3.71927481
51histone H3-K36 demethylation (GO:0070544)3.69540325
52regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.69414319
53negative regulation of T cell apoptotic process (GO:0070233)3.69163176
54T-helper cell differentiation (GO:0042093)3.67549392
55CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.67549392
56regulation of vitamin D biosynthetic process (GO:0060556)3.66458309
57myeloid dendritic cell activation (GO:0001773)3.65169749
58positive thymic T cell selection (GO:0045059)3.64081947
59positive regulation of DNA recombination (GO:0045911)3.59144170
60positive regulation of tolerance induction (GO:0002645)3.58268185
61lymphocyte homeostasis (GO:0002260)3.54792496
62regulation of interleukin-4 production (GO:0032673)3.54321120
63T cell receptor signaling pathway (GO:0050852)3.53107370
64V(D)J recombination (GO:0033151)3.50216076
65regulation of B cell differentiation (GO:0045577)3.48779211
66CD4-positive, alpha-beta T cell differentiation (GO:0043367)3.47503633
67antigen receptor-mediated signaling pathway (GO:0050851)3.45483008
68regulation of tolerance induction (GO:0002643)3.44165281
69regulation of T cell mediated cytotoxicity (GO:0001914)3.43947354
70positive regulation of T cell mediated cytotoxicity (GO:0001916)3.42869170
71regulation of isotype switching (GO:0045191)3.42143575
72negative regulation of lymphocyte mediated immunity (GO:0002707)3.40222617
73B cell receptor signaling pathway (GO:0050853)3.38754073
74regulation of interleukin-2 biosynthetic process (GO:0045076)3.37470039
75radial glial cell differentiation (GO:0060019)3.35435942
76regulation of autophagic vacuole assembly (GO:2000785)3.33462773
77positive regulation of cell killing (GO:0031343)3.32039313
78T cell differentiation (GO:0030217)3.31049928
79response to protozoan (GO:0001562)3.30216625
80regulation of alpha-beta T cell proliferation (GO:0046640)3.28598975
81leukocyte degranulation (GO:0043299)3.28211992
82positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)3.27443235
83regulation of cell killing (GO:0031341)3.20537481
84negative regulation of bone resorption (GO:0045779)3.18323379
85positive regulation of chemokine biosynthetic process (GO:0045080)3.17132337
86positive regulation of immunoglobulin production (GO:0002639)3.17090916
87regulation of MHC class II biosynthetic process (GO:0045346)3.16081841
88regulation of interleukin-17 production (GO:0032660)3.10767368
89leukocyte homeostasis (GO:0001776)3.08619860
90positive regulation of interleukin-4 production (GO:0032753)3.08509233
91CD4-positive, alpha-beta T cell activation (GO:0035710)3.08185180
92positive regulation of B cell mediated immunity (GO:0002714)3.07890852
93positive regulation of immunoglobulin mediated immune response (GO:0002891)3.07890852
94regulation of natural killer cell mediated immunity (GO:0002715)3.07807866
95regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.07807866
96positive regulation of B cell differentiation (GO:0045579)3.04421851
97positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.01026982
98positive regulation of B cell activation (GO:0050871)3.00380594
99regulation of vacuole organization (GO:0044088)2.97058967
100T cell activation involved in immune response (GO:0002286)2.96540152

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse6.74528247
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human6.25553248
3CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human5.00890529
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.90149511
5IRF8_22096565_ChIP-ChIP_GC-B_Human4.80861430
6BP1_19119308_ChIP-ChIP_Hs578T_Human4.02316396
7RUNX_20019798_ChIP-Seq_JUKART_Human3.75467592
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.45406073
9MYB_26560356_Chip-Seq_TH2_Human3.43780375
10STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.06978149
11IRF8_21731497_ChIP-ChIP_J774_Mouse3.00688366
12STAT4_19710469_ChIP-ChIP_TH1__Mouse2.91176199
13MAF_26560356_Chip-Seq_TH1_Human2.79390934
14MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.76355735
15MYB_26560356_Chip-Seq_TH1_Human2.71081304
16IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.65375700
17FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.63998701
18UTX_26944678_Chip-Seq_JUKART_Human2.62255598
19E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.58803007
20GATA3_27048872_Chip-Seq_THYMUS_Human2.56063562
21MYC_22102868_ChIP-Seq_BL_Human2.39738024
22MAF_26560356_Chip-Seq_TH2_Human2.36184924
23VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.31342828
24SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.29551308
25HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.26981312
26SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.16320461
27E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.14441915
28NOTCH1_21737748_ChIP-Seq_TLL_Human2.11943201
29SPI1_23547873_ChIP-Seq_NB4_Human2.09458201
30RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.07794634
31IRF8_27001747_Chip-Seq_BMDM_Mouse1.99307783
32SCL_19346495_ChIP-Seq_HPC-7_Human1.96470793
33VDR_21846776_ChIP-Seq_THP-1_Human1.92497954
34VDR_24763502_ChIP-Seq_THP-1_Human1.83488795
35SPI1_23127762_ChIP-Seq_K562_Human1.82511924
36KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.78244256
37NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.76218092
38KDM2B_26808549_Chip-Seq_DND41_Human1.75481657
39RUNX1_22412390_ChIP-Seq_EML_Mouse1.73219021
40GATA3_26560356_Chip-Seq_TH2_Human1.65461837
41BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.59802034
42SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.57839258
43SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.55047700
44KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.53895906
45MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.53408062
46MYB_21317192_ChIP-Seq_ERMYB_Mouse1.53066676
47KDM2B_26808549_Chip-Seq_SUP-B15_Human1.51269465
48BRD4_27068464_Chip-Seq_AML-cells_Mouse1.39812298
49VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.39454200
50RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.38914516
51LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.31935712
52TCF7_22412390_ChIP-Seq_EML_Mouse1.31837987
53FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.28761141
54CIITA_25753668_ChIP-Seq_RAJI_Human1.28181836
55VDR_24787735_ChIP-Seq_THP-1_Human1.27827215
56LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.21214183
57RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.16797828
58TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.14618795
59KDM2B_26808549_Chip-Seq_JURKAT_Human1.14303090
60STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.13741868
61CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.12736002
62CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06625404
63NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.05763942
64SMAD_19615063_ChIP-ChIP_OVARY_Human1.05760830
65CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03946962
66ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.03346259
67GATA2_22383799_ChIP-Seq_G1ME_Mouse1.00591221
68TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00123477
69GATA1_19941827_ChIP-Seq_MEL_Mouse0.99587103
70GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98287075
71TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.96999851
72CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95931607
73VDR_23849224_ChIP-Seq_CD4+_Human0.95043426
74SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.92503981
75GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.92127888
76PU.1_20513432_ChIP-Seq_Bcells_Mouse0.91902671
77RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91640946
78PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.89168446
79CTCF_21964334_ChIP-Seq_BJAB-B_Human0.88963171
80GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88424637
81PU_27001747_Chip-Seq_BMDM_Mouse0.87074011
82FOXP3_21729870_ChIP-Seq_TREG_Human0.84587938
83GATA1_22383799_ChIP-Seq_G1ME_Mouse0.84380174
84AR_21572438_ChIP-Seq_LNCaP_Human0.83068682
85ELF1_17652178_ChIP-ChIP_JURKAT_Human0.82797766
86PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.81823089
87Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.81319037
88FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80576386
89CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.79100206
90GATA1_19941826_ChIP-Seq_K562_Human0.78281060
91ELK3_25401928_ChIP-Seq_HUVEC_Human0.76947768
92GATA3_26560356_Chip-Seq_TH1_Human0.76874917
93SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76702997
94NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.73104944
95SPI1_20517297_ChIP-Seq_HL60_Human0.72299407
96ELF1_20517297_ChIP-Seq_JURKAT_Human0.72154101
97SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.71995183
98BCL6_27268052_Chip-Seq_Bcells_Human0.71535479
99CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.70877050
100CTCF_21964334_Chip-Seq_Bcells_Human0.67794891

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology5.04140498
2MP0005671_abnormal_response_to4.77899371
3MP0001835_abnormal_antigen_presentation4.74500161
4MP0001873_stomach_inflammation4.23743766
5MP0003436_decreased_susceptibility_to3.46550472
6MP0004381_abnormal_hair_follicle3.35773647
7MP0001800_abnormal_humoral_immune3.34186615
8MP0005000_abnormal_immune_tolerance3.31174916
9MP0001790_abnormal_immune_system3.05137034
10MP0005387_immune_system_phenotype3.05137034
11MP0002405_respiratory_system_inflammati3.03814094
12MP0009785_altered_susceptibility_to3.03649651
13MP0009333_abnormal_splenocyte_physiolog3.01218214
14MP0000685_abnormal_immune_system2.96417873
15MP0003724_increased_susceptibility_to2.93683915
16MP0002148_abnormal_hypersensitivity_rea2.81399288
17MP0002420_abnormal_adaptive_immunity2.63790465
18MP0000703_abnormal_thymus_morphology2.63022935
19MP0001819_abnormal_immune_cell2.59020268
20MP0002723_abnormal_immune_serum2.47881004
21MP0005025_abnormal_response_to2.43238208
22MP0002452_abnormal_antigen_presenting2.34878753
23MP0010155_abnormal_intestine_physiology2.34742078
24MP0002419_abnormal_innate_immunity2.24759987
25MP0002398_abnormal_bone_marrow2.20418194
26MP0002722_abnormal_immune_system2.10391708
27MP0002132_abnormal_respiratory_system2.09159911
28MP0000716_abnormal_immune_system2.05914204
29MP0000689_abnormal_spleen_morphology1.88309018
30MP0003866_abnormal_defecation1.81874374
31MP0005075_abnormal_melanosome_morpholog1.78132833
32MP0000465_gastrointestinal_hemorrhage1.73418587
33MP0001845_abnormal_inflammatory_respons1.70946508
34MP0003300_gastrointestinal_ulcer1.70780350
35MP0004947_skin_inflammation1.61460314
36MP0002166_altered_tumor_susceptibility1.61299131
37MP0002933_joint_inflammation1.58832783
38MP0002429_abnormal_blood_cell1.56886969
39MP0005166_decreased_susceptibility_to1.53055087
40MP0003303_peritoneal_inflammation1.49443812
41MP0006082_CNS_inflammation1.47596192
42MP0005464_abnormal_platelet_physiology1.41340917
43MP0001533_abnormal_skeleton_physiology1.32012880
44MP0005310_abnormal_salivary_gland1.31783218
45MP0002277_abnormal_respiratory_mucosa1.24757205
46MP0004782_abnormal_surfactant_physiolog1.18559191
47MP0002138_abnormal_hepatobiliary_system1.17495233
48MP0001958_emphysema1.17067769
49MP0009278_abnormal_bone_marrow1.13024524
50MP0001849_ear_inflammation1.12510011
51MP0001663_abnormal_digestive_system1.08489523
52MP0000490_abnormal_crypts_of1.06641718
53MP0008469_abnormal_protein_level1.05567528
54MP0003828_pulmonary_edema1.03317835
55MP0001853_heart_inflammation1.01720996
56MP0002006_tumorigenesis0.96686142
57MP0009840_abnormal_foam_cell0.93546014
58MP0001348_abnormal_lacrimal_gland0.92968737
59MP0002998_abnormal_bone_remodeling0.92001555
60MP0001851_eye_inflammation0.91725415
61MP0002396_abnormal_hematopoietic_system0.89436040
62MP0000858_altered_metastatic_potential0.86330808
63MP0002163_abnormal_gland_morphology0.86323790
64MP0002693_abnormal_pancreas_physiology0.86274723
65MP0000678_abnormal_parathyroid_gland0.79336055
66MP0002019_abnormal_tumor_incidence0.77749898
67MP0004484_altered_response_of0.75774153
68MP0008004_abnormal_stomach_pH0.75398884
69MP0006035_abnormal_mitochondrial_morpho0.73601829
70MP0010307_abnormal_tumor_latency0.72312501
71MP0009765_abnormal_xenobiotic_induced0.71437409
72MP0003448_altered_tumor_morphology0.67128347
73MP0000681_abnormal_thyroid_gland0.62620514
74MP0005381_digestive/alimentary_phenotyp0.61479628
75MP0003172_abnormal_lysosome_physiology0.59524730
76MP0009764_decreased_sensitivity_to0.58741743
77MP0001270_distended_abdomen0.55899797
78MP0004808_abnormal_hematopoietic_stem0.54809302
79MP0005451_abnormal_body_composition0.53959343
80MP0004883_abnormal_blood_vessel0.53417814
81MP0005390_skeleton_phenotype0.53301510
82MP0001545_abnormal_hematopoietic_system0.52361616
83MP0005397_hematopoietic_system_phenotyp0.52361616
84MP0008569_lethality_at_weaning0.52112870
85MP0003315_abnormal_perineum_morphology0.47671696
86MP0003795_abnormal_bone_structure0.47267149
87MP0005388_respiratory_system_phenotype0.46601549
88MP0002133_abnormal_respiratory_system0.46601549
89MP0000015_abnormal_ear_pigmentation0.44600905
90MP0002009_preneoplasia0.44093955
91MP0002136_abnormal_kidney_physiology0.43328713
92MP0009763_increased_sensitivity_to0.43058422
93MP0000477_abnormal_intestine_morphology0.42906210
94MP0000604_amyloidosis0.39788091
95MP0008961_abnormal_basal_metabolism0.39448932
96MP0008873_increased_physiological_sensi0.39042197
97MP0009115_abnormal_fat_cell0.38209771
98MP0001881_abnormal_mammary_gland0.37442454
99MP0002254_reproductive_system_inflammat0.37050091
100MP0003091_abnormal_cell_migration0.34906937

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)6.84109310
2Stomatitis (HP:0010280)6.44047292
3Abnormality of T cell number (HP:0011839)6.35573775
4Panhypogammaglobulinemia (HP:0003139)5.41086709
5Severe combined immunodeficiency (HP:0004430)5.18415619
6Abnormality of T cells (HP:0002843)5.03325112
7Recurrent fungal infections (HP:0002841)4.98498598
8Eczematoid dermatitis (HP:0000976)4.67413119
9Elevated erythrocyte sedimentation rate (HP:0003565)4.63889681
10IgG deficiency (HP:0004315)4.46180398
11Autoimmune hemolytic anemia (HP:0001890)4.40660748
12Thyroiditis (HP:0100646)4.32416116
13Recurrent viral infections (HP:0004429)4.32323160
14Abnormal delayed hypersensitivity skin test (HP:0002963)4.32101635
15Eosinophilia (HP:0001880)4.24210843
16Myositis (HP:0100614)4.10651800
17Combined immunodeficiency (HP:0005387)4.10602468
18B lymphocytopenia (HP:0010976)4.09925755
19Granulocytopenia (HP:0001913)4.03848989
20Increased IgM level (HP:0003496)4.01953592
21Abnormality of B cell number (HP:0010975)4.01344637
22Hypoplasia of the thymus (HP:0000778)3.97421488
23Abnormality of eosinophils (HP:0001879)3.92863951
24Abnormality of the columella (HP:0009929)3.89767141
25Chronic diarrhea (HP:0002028)3.75638828
26Meningitis (HP:0001287)3.67914636
27Optic neuritis (HP:0100653)3.56895784
28Retrobulbar optic neuritis (HP:0100654)3.56895784
29Recurrent cutaneous fungal infections (HP:0011370)3.51299458
30Chronic mucocutaneous candidiasis (HP:0002728)3.51299458
31Abnormality of T cell physiology (HP:0011840)3.46558205
32Orchitis (HP:0100796)3.46296211
33IgM deficiency (HP:0002850)3.45678544
34Leukocytosis (HP:0001974)3.45536038
35Vasculitis (HP:0002633)3.36147375
36Recurrent bacterial skin infections (HP:0005406)3.21529688
37Recurrent abscess formation (HP:0002722)3.21065978
38Chronic obstructive pulmonary disease (HP:0006510)3.20939374
39Obstructive lung disease (HP:0006536)3.20939374
40Pustule (HP:0200039)3.10353133
41IgA deficiency (HP:0002720)3.08775096
42Lymphopenia (HP:0001888)3.08324266
43Abnormality of macrophages (HP:0004311)3.07429189
44Gastrointestinal infarctions (HP:0005244)3.06454508
45Encephalitis (HP:0002383)3.04235074
46Spontaneous hematomas (HP:0007420)3.01501495
47Pulmonary infiltrates (HP:0002113)3.00519651
48Hypoproteinemia (HP:0003075)2.97438235
49Abnormality of cells of the lymphoid lineage (HP:0012140)2.95690180
50Inflammation of the large intestine (HP:0002037)2.86536348
51Mediastinal lymphadenopathy (HP:0100721)2.78805722
52Gastrointestinal inflammation (HP:0004386)2.75268641
53Hemoptysis (HP:0002105)2.75197766
54Increased IgE level (HP:0003212)2.75064929
55Joint swelling (HP:0001386)2.74479729
56Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.74090587
57Papilledema (HP:0001085)2.71836665
58Keratoconjunctivitis sicca (HP:0001097)2.69282786
59Recurrent bronchitis (HP:0002837)2.64886462
60Recurrent skin infections (HP:0001581)2.64462742
61Thoracic kyphosis (HP:0002942)2.64160826
62Keratoconjunctivitis (HP:0001096)2.62949150
63Hypochromic anemia (HP:0001931)2.62526925
64Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.62511108
65Pulmonary embolism (HP:0002204)2.61014114
66Reduced antithrombin III activity (HP:0001976)2.59685507
67Recurrent sinusitis (HP:0011108)2.57823525
68Hypochromic microcytic anemia (HP:0004840)2.55312748
69Chest pain (HP:0100749)2.54114074
70Colitis (HP:0002583)2.40217869
71Verrucae (HP:0200043)2.34504770
72Papilloma (HP:0012740)2.34504770
73Hypergammaglobulinemia (HP:0010702)2.33996615
74Prolonged bleeding time (HP:0003010)2.30928122
75Autoimmune thrombocytopenia (HP:0001973)2.30250050
76Agammaglobulinemia (HP:0004432)2.28096421
77Recurrent gram-negative bacterial infections (HP:0005420)2.25636052
78Gingivitis (HP:0000230)2.24282678
79Abnormality of the frontal sinuses (HP:0002687)2.22718606
80Lymphoma (HP:0002665)2.17842699
81Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.16428963
82Basal ganglia calcification (HP:0002135)2.14682177
83Gangrene (HP:0100758)2.11746332
84Epistaxis (HP:0000421)2.11567950
85Microcytic anemia (HP:0001935)2.11410042
86Basal cell carcinoma (HP:0002671)2.10453309
87Aplasia/Hypoplasia of the thymus (HP:0010515)2.04476346
88Lower limb hyperreflexia (HP:0002395)2.02397507
89Urticaria (HP:0001025)2.01185701
90Chronic otitis media (HP:0000389)1.99536267
91Arterial thrombosis (HP:0004420)1.96272173
92Abnormality of the prostate (HP:0008775)1.94286901
93Sepsis (HP:0100806)1.93545315
94Anorexia (HP:0002039)1.89991995
95Deep palmar crease (HP:0006191)1.87452740
96Hepatitis (HP:0012115)1.82947421
97Abnormality of the pleura (HP:0002103)1.80896292
98Polyneuropathy (HP:0001271)1.80676689
99Acute hepatic failure (HP:0006554)1.80239142
100Hematochezia (HP:0002573)1.77711010

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK5.09262029
2MAP4K14.98358047
3NLK4.24728176
4ZAP703.68547483
5MARK33.08798030
6FES2.38051355
7BTK2.23050271
8GRK62.03174992
9ITK1.99504056
10RIPK41.94502357
11TNK21.92778801
12CSNK1A1L1.84621801
13TYK21.81061708
14SYK1.80483302
15MAP3K101.79195519
16MAP3K131.73475715
17CSNK1G31.70630344
18JAK11.67545551
19MAP2K71.66979725
20PRPF4B1.64558297
21CSK1.63361081
22HCK1.52799657
23JAK31.46923477
24PRKCQ1.43537976
25PDGFRB1.43173357
26LCK1.42559487
27BLK1.42534288
28PASK1.39211666
29IKBKE1.36564918
30CAMKK21.35437292
31CSNK1G11.28023355
32MAP3K11.26094219
33CAMKK11.24407882
34CSNK1G21.16776717
35EPHB11.15234734
36FGFR31.14076366
37IRAK41.09989663
38EIF2AK31.09143431
39TAOK31.05607960
40TEC1.01658245
41FGFR41.00757308
42TLK10.99498126
43STK100.98676229
44MELK0.94335886
45JAK20.93251373
46RPS6KA40.93113411
47NEK20.92372936
48SIK30.91630514
49MAP3K30.90687746
50FGFR20.90646388
51HIPK20.89657826
52CDK120.89617971
53LYN0.86947013
54MAP3K70.82620215
55PDK10.79306817
56MAPK120.79039978
57MAP3K50.75009438
58SIK20.74654532
59ERN10.74043403
60SGK2230.72520050
61SGK4940.72520050
62MAP2K30.72444441
63MAP3K140.71404208
64MAPK110.70555692
65TAOK10.68467055
66RET0.67655347
67PKN20.67567413
68CDK30.66167205
69DYRK30.66054361
70STK40.62939042
71MST40.59259396
72IKBKB0.59207547
73FRK0.57512544
74TBK10.56159107
75FGR0.55922399
76LRRK20.54823425
77CLK10.54801677
78SGK20.54374491
79RPS6KB10.53127364
80PIM10.46727402
81CSF1R0.40470106
82MARK20.40388775
83CDK40.39964947
84FYN0.38570332
85MAP3K80.38457514
86PDPK10.35604361
87STK380.35349865
88SGK30.35171033
89MAP3K110.34571740
90PINK10.34103998
91PIK3CG0.32928828
92CAMK40.32641802
93BMPR1B0.32632073
94TRIB30.31433642
95TYRO30.31312636
96CDK80.29553785
97RPS6KL10.29291031
98RPS6KC10.29291031
99ICK0.27819321
100STK110.27117545

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.06470799
2T cell receptor signaling pathway_Homo sapiens_hsa046603.91268941
3Allograft rejection_Homo sapiens_hsa053303.10902755
4Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.85102278
5Graft-versus-host disease_Homo sapiens_hsa053322.72970450
6Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.69253770
7Autoimmune thyroid disease_Homo sapiens_hsa053202.45116762
8Measles_Homo sapiens_hsa051622.24602446
9Hematopoietic cell lineage_Homo sapiens_hsa046402.21371762
10Fc epsilon RI signaling pathway_Homo sapiens_hsa046642.20228358
11Type I diabetes mellitus_Homo sapiens_hsa049402.09617092
12B cell receptor signaling pathway_Homo sapiens_hsa046622.02827225
13Osteoclast differentiation_Homo sapiens_hsa043801.98524505
14NF-kappa B signaling pathway_Homo sapiens_hsa040641.90929364
15Antigen processing and presentation_Homo sapiens_hsa046121.83295252
16Malaria_Homo sapiens_hsa051441.82586141
17Acute myeloid leukemia_Homo sapiens_hsa052211.75007260
18Jak-STAT signaling pathway_Homo sapiens_hsa046301.74464991
19Leishmaniasis_Homo sapiens_hsa051401.61488859
20Olfactory transduction_Homo sapiens_hsa047401.60451477
21Herpes simplex infection_Homo sapiens_hsa051681.44779435
22Tuberculosis_Homo sapiens_hsa051521.42774268
23Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.39479780
24Intestinal immune network for IgA production_Homo sapiens_hsa046721.38515835
25African trypanosomiasis_Homo sapiens_hsa051431.35740547
26Regulation of autophagy_Homo sapiens_hsa041401.32474641
27Rheumatoid arthritis_Homo sapiens_hsa053231.30056752
28Phototransduction_Homo sapiens_hsa047441.29332253
29Hepatitis B_Homo sapiens_hsa051611.28959686
30Viral myocarditis_Homo sapiens_hsa054161.27978618
31Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.26100864
32RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.23117234
33TNF signaling pathway_Homo sapiens_hsa046681.20061266
34Endometrial cancer_Homo sapiens_hsa052131.18821688
35Chemokine signaling pathway_Homo sapiens_hsa040621.18712727
36Non-small cell lung cancer_Homo sapiens_hsa052231.18381054
37Toll-like receptor signaling pathway_Homo sapiens_hsa046201.16791085
38Phosphatidylinositol signaling system_Homo sapiens_hsa040701.14298483
39Thyroid cancer_Homo sapiens_hsa052161.12187243
40Systemic lupus erythematosus_Homo sapiens_hsa053221.11999460
41Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.09635348
42Toxoplasmosis_Homo sapiens_hsa051451.07728114
43Influenza A_Homo sapiens_hsa051641.01844133
44Staphylococcus aureus infection_Homo sapiens_hsa051501.01108197
45Pertussis_Homo sapiens_hsa051330.92989440
46Viral carcinogenesis_Homo sapiens_hsa052030.92782936
47Glioma_Homo sapiens_hsa052140.90372203
48Long-term potentiation_Homo sapiens_hsa047200.89162997
49NOD-like receptor signaling pathway_Homo sapiens_hsa046210.88603823
50HTLV-I infection_Homo sapiens_hsa051660.88061953
51Apoptosis_Homo sapiens_hsa042100.86728791
52Asthma_Homo sapiens_hsa053100.85290195
53Hepatitis C_Homo sapiens_hsa051600.83522264
54Renin secretion_Homo sapiens_hsa049240.81227924
55Epstein-Barr virus infection_Homo sapiens_hsa051690.80330571
56Colorectal cancer_Homo sapiens_hsa052100.79462236
57Sphingolipid signaling pathway_Homo sapiens_hsa040710.76718083
58FoxO signaling pathway_Homo sapiens_hsa040680.76532066
59Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.75037611
60Salmonella infection_Homo sapiens_hsa051320.74395497
61Platelet activation_Homo sapiens_hsa046110.73445076
62Neurotrophin signaling pathway_Homo sapiens_hsa047220.73331498
63Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.72581355
64Oxytocin signaling pathway_Homo sapiens_hsa049210.71904046
65Alcoholism_Homo sapiens_hsa050340.69973900
66Prostate cancer_Homo sapiens_hsa052150.69869048
67Leukocyte transendothelial migration_Homo sapiens_hsa046700.68750637
68GnRH signaling pathway_Homo sapiens_hsa049120.65775670
69VEGF signaling pathway_Homo sapiens_hsa043700.64809625
70Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.59808964
71Pancreatic cancer_Homo sapiens_hsa052120.56631195
72Legionellosis_Homo sapiens_hsa051340.54935990
73Aldosterone synthesis and secretion_Homo sapiens_hsa049250.54927391
74Estrogen signaling pathway_Homo sapiens_hsa049150.54430984
75SNARE interactions in vesicular transport_Homo sapiens_hsa041300.54214169
76Transcriptional misregulation in cancer_Homo sapiens_hsa052020.50577830
77Choline metabolism in cancer_Homo sapiens_hsa052310.50146379
78Ras signaling pathway_Homo sapiens_hsa040140.50093448
79Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.49929708
80Chronic myeloid leukemia_Homo sapiens_hsa052200.49855501
81mTOR signaling pathway_Homo sapiens_hsa041500.46673627
82Proteasome_Homo sapiens_hsa030500.46373327
83Rap1 signaling pathway_Homo sapiens_hsa040150.46053031
84Melanogenesis_Homo sapiens_hsa049160.45350833
85MAPK signaling pathway_Homo sapiens_hsa040100.45148802
86Gastric acid secretion_Homo sapiens_hsa049710.43865775
87cGMP-PKG signaling pathway_Homo sapiens_hsa040220.43670329
88Prolactin signaling pathway_Homo sapiens_hsa049170.40824346
89Vascular smooth muscle contraction_Homo sapiens_hsa042700.40769097
90Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.40357287
91Endocytosis_Homo sapiens_hsa041440.38208214
92HIF-1 signaling pathway_Homo sapiens_hsa040660.38011802
93Salivary secretion_Homo sapiens_hsa049700.36925481
94Circadian rhythm_Homo sapiens_hsa047100.36895048
95Insulin signaling pathway_Homo sapiens_hsa049100.36161363
96Amphetamine addiction_Homo sapiens_hsa050310.35916435
97Longevity regulating pathway - mammal_Homo sapiens_hsa042110.33863103
98Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.33763032
99Inositol phosphate metabolism_Homo sapiens_hsa005620.33205184
100Phagosome_Homo sapiens_hsa041450.31318705

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