TRBV11-3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative T cell selection (GO:0043383)8.19463975
2negative thymic T cell selection (GO:0045060)7.67229633
3positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)7.02211887
4positive regulation of gamma-delta T cell activation (GO:0046645)6.38450404
5thymic T cell selection (GO:0045061)6.21669334
6positive T cell selection (GO:0043368)6.14814859
7positive regulation of granulocyte differentiation (GO:0030854)5.89518537
8regulation of isotype switching to IgG isotypes (GO:0048302)5.81013066
9positive thymic T cell selection (GO:0045059)5.69961991
10T cell selection (GO:0045058)5.68871843
11positive regulation of interleukin-2 biosynthetic process (GO:0045086)5.50059164
12leukocyte aggregation (GO:0070486)5.31174931
13regulation of gamma-delta T cell differentiation (GO:0045586)5.22900753
14regulation of B cell receptor signaling pathway (GO:0050855)4.68778968
15antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.66372053
16V(D)J recombination (GO:0033151)4.64653156
17antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.59675604
18tolerance induction (GO:0002507)4.59550592
19regulation of gamma-delta T cell activation (GO:0046643)4.57662573
20cellular response to interleukin-15 (GO:0071350)4.55445137
21Peyers patch development (GO:0048541)4.49503187
22mucosal-associated lymphoid tissue development (GO:0048537)4.49503187
23positive regulation of alpha-beta T cell proliferation (GO:0046641)4.46367054
24antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.31860401
25response to interleukin-15 (GO:0070672)4.28862253
26regulation of regulatory T cell differentiation (GO:0045589)4.24365873
27regulation of T cell tolerance induction (GO:0002664)4.19815443
28regulation of alpha-beta T cell proliferation (GO:0046640)4.17660402
29antigen processing and presentation of endogenous antigen (GO:0019883)4.14180318
30T cell differentiation involved in immune response (GO:0002292)4.09236792
31alpha-beta T cell differentiation involved in immune response (GO:0002293)4.09236792
32alpha-beta T cell activation involved in immune response (GO:0002287)4.09236792
33alpha-beta T cell differentiation (GO:0046632)4.07821985
34negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.06973372
35negative regulation of cell killing (GO:0031342)4.06973372
36T cell migration (GO:0072678)4.01372907
37regulation of interleukin-2 biosynthetic process (GO:0045076)4.01135603
38positive regulation of tolerance induction (GO:0002645)3.97313784
39regulation of granulocyte differentiation (GO:0030852)3.92811226
40T cell receptor signaling pathway (GO:0050852)3.89320363
41positive regulation of isotype switching (GO:0045830)3.88106233
42deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.74616680
43positive regulation of T cell differentiation in thymus (GO:0033089)3.73308704
44mast cell activation (GO:0045576)3.67192813
45alpha-beta T cell activation (GO:0046631)3.66183690
46positive regulation of interleukin-4 production (GO:0032753)3.61382758
47mast cell degranulation (GO:0043303)3.57033414
48mast cell activation involved in immune response (GO:0002279)3.57033414
49antigen receptor-mediated signaling pathway (GO:0050851)3.51845717
50regulation of tolerance induction (GO:0002643)3.48066417
51regulation of interleukin-12 biosynthetic process (GO:0045075)3.46615026
52regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.45201378
53regulation of interleukin-4 production (GO:0032673)3.44287521
54myeloid dendritic cell activation (GO:0001773)3.40659168
55positive regulation of calcium-mediated signaling (GO:0050850)3.39075809
56regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.36979697
57regulation of natural killer cell mediated immunity (GO:0002715)3.36979697
58T cell differentiation (GO:0030217)3.35683397
59positive regulation of interleukin-2 production (GO:0032743)3.34913422
60positive regulation of DNA recombination (GO:0045911)3.30993124
61negative regulation of interleukin-17 production (GO:0032700)3.30945282
62positive regulation of alpha-beta T cell activation (GO:0046635)3.30625298
63myeloid dendritic cell differentiation (GO:0043011)3.30170313
64positive regulation of natural killer cell mediated immunity (GO:0002717)3.27588325
65regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.26530649
66CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.26105059
67T-helper cell differentiation (GO:0042093)3.26105059
68T cell costimulation (GO:0031295)3.22108477
69negative regulation of thymocyte apoptotic process (GO:0070244)3.21429024
70negative regulation of T cell apoptotic process (GO:0070233)3.20277063
71lymphocyte costimulation (GO:0031294)3.19495679
72positive regulation of cell killing (GO:0031343)3.18158628
73regulation of isotype switching (GO:0045191)3.15827399
74purine nucleotide salvage (GO:0032261)3.13945540
75telomere maintenance via semi-conservative replication (GO:0032201)3.13054630
76positive regulation of B cell differentiation (GO:0045579)3.09369291
77DNA strand elongation involved in DNA replication (GO:0006271)3.09348088
78T cell homeostasis (GO:0043029)3.06921652
79T cell activation (GO:0042110)3.02674954
80positive regulation of immunoglobulin production (GO:0002639)3.02119699
81interferon-gamma production (GO:0032609)3.01968193
82positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.01153702
83regulation of alpha-beta T cell activation (GO:0046634)3.00784478
84positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.00501431
85positive regulation of alpha-beta T cell differentiation (GO:0046638)2.99913458
86cytidine deamination (GO:0009972)2.98608246
87cytidine metabolic process (GO:0046087)2.98608246
88cytidine catabolic process (GO:0006216)2.98608246
89cellular response to interleukin-4 (GO:0071353)2.95719097
90negative regulation of phagocytosis (GO:0050765)2.95085437
91regulation of T cell receptor signaling pathway (GO:0050856)2.92516321
92DNA strand elongation (GO:0022616)2.91686308
93antigen processing and presentation via MHC class Ib (GO:0002475)2.90974373
94regulation of cell killing (GO:0031341)2.89578481
95activated T cell proliferation (GO:0050798)2.89427901
96regulation of defense response to virus by virus (GO:0050690)2.89160295
97signal complex assembly (GO:0007172)2.88754693
98positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.88475982
99regulation of B cell differentiation (GO:0045577)2.88032940
100mature B cell differentiation involved in immune response (GO:0002313)2.87069031

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.88606623
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.21298109
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.94755017
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.77231254
5RUNX_20019798_ChIP-Seq_JUKART_Human3.37947565
6MYB_26560356_Chip-Seq_TH2_Human3.34525903
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.01784977
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.98305029
9MYC_22102868_ChIP-Seq_BL_Human2.97616115
10ELF1_17652178_ChIP-ChIP_JURKAT_Human2.88016687
11UTX_26944678_Chip-Seq_JUKART_Human2.75885172
12STAT4_19710469_ChIP-ChIP_TH1__Mouse2.53685755
13NOTCH1_21737748_ChIP-Seq_TLL_Human2.51192935
14MAF_26560356_Chip-Seq_TH1_Human2.45527638
15E2F4_17652178_ChIP-ChIP_JURKAT_Human2.40538607
16STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.38467837
17MYB_26560356_Chip-Seq_TH1_Human2.36797866
18GATA3_27048872_Chip-Seq_THYMUS_Human2.33104563
19SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.30015103
20MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.23936366
21IRF8_21731497_ChIP-ChIP_J774_Mouse2.12909899
22MAF_26560356_Chip-Seq_TH2_Human2.12524924
23EGR1_19374776_ChIP-ChIP_THP-1_Human2.12248904
24IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.11543404
25VDR_21846776_ChIP-Seq_THP-1_Human2.09537725
26FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.06134166
27EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.02986688
28CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.01183876
29CIITA_25753668_ChIP-Seq_RAJI_Human1.95679154
30E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.95460184
31SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.93185234
32FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.90649842
33SPI1_23547873_ChIP-Seq_NB4_Human1.82971155
34RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.79252058
35NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.73624997
36BP1_19119308_ChIP-ChIP_Hs578T_Human1.73340408
37HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.68565954
38VDR_24763502_ChIP-Seq_THP-1_Human1.66466130
39FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.64507434
40SCL_19346495_ChIP-Seq_HPC-7_Human1.60387920
41E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.58752446
42VDR_23849224_ChIP-Seq_CD4+_Human1.57376151
43KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.57310342
44TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.54979595
45HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.53280216
46FOXP3_21729870_ChIP-Seq_TREG_Human1.50990136
47GATA3_26560356_Chip-Seq_TH2_Human1.49300766
48ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.45646420
49FOXM1_23109430_ChIP-Seq_U2OS_Human1.42961311
50SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.42856763
51EST1_17652178_ChIP-ChIP_JURKAT_Human1.40253394
52RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.38796340
53RUNX1_22412390_ChIP-Seq_EML_Mouse1.37324877
54MYB_21317192_ChIP-Seq_ERMYB_Mouse1.32376543
55MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.31460075
56KDM2B_26808549_Chip-Seq_DND41_Human1.30845482
57SPI1_23127762_ChIP-Seq_K562_Human1.30289546
58NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.26861032
59KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.26194853
60FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.26148344
61SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.23407930
62TCF7_22412390_ChIP-Seq_EML_Mouse1.19892555
63BRD4_27068464_Chip-Seq_AML-cells_Mouse1.19457901
64LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.07534236
65TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.06781389
66GATA2_22383799_ChIP-Seq_G1ME_Mouse1.06342696
67IRF8_27001747_Chip-Seq_BMDM_Mouse1.05792500
68JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.02565382
69MYC_18555785_ChIP-Seq_MESCs_Mouse0.99238146
70LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.98882086
71DCP1A_22483619_ChIP-Seq_HELA_Human0.98146129
72ETS1_20019798_ChIP-Seq_JURKAT_Human0.97727374
73HOXB4_20404135_ChIP-ChIP_EML_Mouse0.96997336
74TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96103650
75NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.95129851
76GABP_17652178_ChIP-ChIP_JURKAT_Human0.94629905
77PU.1_20513432_ChIP-Seq_Bcells_Mouse0.94137699
78YY1_21170310_ChIP-Seq_MESCs_Mouse0.94019609
79VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.91956637
80ELF1_20517297_ChIP-Seq_JURKAT_Human0.89796396
81FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88944759
82CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.88526549
83MYC_18358816_ChIP-ChIP_MESCs_Mouse0.88159201
84KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.86038358
85E2F1_21310950_ChIP-Seq_MCF-7_Human0.85876880
86KDM2B_26808549_Chip-Seq_JURKAT_Human0.85237082
87CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.84642695
88GATA1_22383799_ChIP-Seq_G1ME_Mouse0.84378787
89BCL6_27268052_Chip-Seq_Bcells_Human0.84318153
90MYC_19030024_ChIP-ChIP_MESCs_Mouse0.83591616
91KDM5A_27292631_Chip-Seq_BREAST_Human0.82890562
92CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.81670108
93MYC_19079543_ChIP-ChIP_MESCs_Mouse0.80968642
94KDM2B_26808549_Chip-Seq_SUP-B15_Human0.80484630
95GABP_19822575_ChIP-Seq_HepG2_Human0.80345440
96RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80080041
97CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.79114295
98PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.78760821
99GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.78602576
100GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.77541441

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology5.60697573
2MP0005671_abnormal_response_to4.57697854
3MP0001835_abnormal_antigen_presentation4.13265688
4MP0001873_stomach_inflammation3.34867417
5MP0009333_abnormal_splenocyte_physiolog3.17051097
6MP0003436_decreased_susceptibility_to3.12329038
7MP0005000_abnormal_immune_tolerance3.08276236
8MP0001800_abnormal_humoral_immune2.99532636
9MP0000703_abnormal_thymus_morphology2.95139541
10MP0000685_abnormal_immune_system2.90442761
11MP0002405_respiratory_system_inflammati2.86923447
12MP0003724_increased_susceptibility_to2.76984961
13MP0005387_immune_system_phenotype2.60914340
14MP0001790_abnormal_immune_system2.60914340
15MP0009785_altered_susceptibility_to2.58957813
16MP0002420_abnormal_adaptive_immunity2.57234277
17MP0001819_abnormal_immune_cell2.53289090
18MP0002398_abnormal_bone_marrow2.51715437
19MP0003300_gastrointestinal_ulcer2.42401053
20MP0002148_abnormal_hypersensitivity_rea2.35306816
21MP0005025_abnormal_response_to2.34340502
22MP0002723_abnormal_immune_serum2.31658965
23MP0002166_altered_tumor_susceptibility2.30740487
24MP0002452_abnormal_antigen_presenting2.23783293
25MP0004381_abnormal_hair_follicle2.23321519
26MP0002163_abnormal_gland_morphology2.20321109
27MP0002722_abnormal_immune_system2.16461606
28MP0000716_abnormal_immune_system2.16351916
29MP0000689_abnormal_spleen_morphology1.96559983
30MP0010155_abnormal_intestine_physiology1.95812058
31MP0002396_abnormal_hematopoietic_system1.90214984
32MP0003866_abnormal_defecation1.85637902
33MP0008057_abnormal_DNA_replication1.84640712
34MP0002419_abnormal_innate_immunity1.82554995
35MP0002429_abnormal_blood_cell1.75698144
36MP0002006_tumorigenesis1.67769301
37MP0005310_abnormal_salivary_gland1.66206607
38MP0005451_abnormal_body_composition1.64895471
39MP0001853_heart_inflammation1.62995759
40MP0010094_abnormal_chromosome_stability1.61487111
41MP0001845_abnormal_inflammatory_respons1.51368479
42MP0009697_abnormal_copulation1.51337523
43MP0002933_joint_inflammation1.48749289
44MP0004947_skin_inflammation1.44643947
45MP0005075_abnormal_melanosome_morpholog1.40131812
46MP0002009_preneoplasia1.37289980
47MP0001346_abnormal_lacrimal_gland1.36109473
48MP0000490_abnormal_crypts_of1.29289353
49MP0000465_gastrointestinal_hemorrhage1.21047428
50MP0003303_peritoneal_inflammation1.19742946
51MP0001533_abnormal_skeleton_physiology1.15853562
52MP0005379_endocrine/exocrine_gland_phen1.15560123
53MP0002019_abnormal_tumor_incidence1.13000670
54MP0002277_abnormal_respiratory_mucosa1.11711382
55MP0003693_abnormal_embryo_hatching1.11105889
56MP0003252_abnormal_bile_duct1.10634228
57MP0009278_abnormal_bone_marrow1.10507828
58MP0006082_CNS_inflammation1.10501551
59MP0005464_abnormal_platelet_physiology1.07589592
60MP0002132_abnormal_respiratory_system1.06045368
61MP0008469_abnormal_protein_level1.03723925
62MP0003077_abnormal_cell_cycle1.01673057
63MP0003111_abnormal_nucleus_morphology0.97845877
64MP0004808_abnormal_hematopoietic_stem0.94960383
65MP0005166_decreased_susceptibility_to0.88477289
66MP0002693_abnormal_pancreas_physiology0.85597455
67MP0003448_altered_tumor_morphology0.78427544
68MP0000858_altered_metastatic_potential0.77566660
69MP0004957_abnormal_blastocyst_morpholog0.77136014
70MP0001348_abnormal_lacrimal_gland0.76600931
71MP0002998_abnormal_bone_remodeling0.74433086
72MP0009765_abnormal_xenobiotic_induced0.70876730
73MP0001663_abnormal_digestive_system0.70090320
74MP0001919_abnormal_reproductive_system0.68735422
75MP0008961_abnormal_basal_metabolism0.64504830
76MP0000313_abnormal_cell_death0.64023548
77MP0001851_eye_inflammation0.61790358
78MP0006035_abnormal_mitochondrial_morpho0.60382228
79MP0001958_emphysema0.59534266
80MP0009764_decreased_sensitivity_to0.59530868
81MP0009763_increased_sensitivity_to0.59278998
82MP0000477_abnormal_intestine_morphology0.52721409
83MP0008877_abnormal_DNA_methylation0.51373887
84MP0010307_abnormal_tumor_latency0.50737710
85MP0000609_abnormal_liver_physiology0.47290014
86MP0003795_abnormal_bone_structure0.47031634
87MP0002138_abnormal_hepatobiliary_system0.46727778
88MP0008058_abnormal_DNA_repair0.46263121
89MP0008569_lethality_at_weaning0.46110138
90MP0003806_abnormal_nucleotide_metabolis0.45825887
91MP0004185_abnormal_adipocyte_glucose0.45074404
92MP0000350_abnormal_cell_proliferation0.44616060
93MP0005266_abnormal_metabolism0.42838665
94MP0004782_abnormal_surfactant_physiolog0.41599707
95MP0000681_abnormal_thyroid_gland0.41335162
96MP0004510_myositis0.41084491
97MP0001730_embryonic_growth_arrest0.39949667
98MP0001986_abnormal_taste_sensitivity0.39408403
99MP0006036_abnormal_mitochondrial_physio0.39249779
100MP0001881_abnormal_mammary_gland0.38262492

Predicted human phenotypes

RankGene SetZ-score
1Severe combined immunodeficiency (HP:0004430)7.34146112
2Autoimmune hemolytic anemia (HP:0001890)6.17503404
3Combined immunodeficiency (HP:0005387)6.15786590
4B lymphocytopenia (HP:0010976)5.93610889
5T lymphocytopenia (HP:0005403)5.86314053
6Increased IgM level (HP:0003496)5.70939904
7Abnormality of B cell number (HP:0010975)5.53861639
8Abnormality of T cell number (HP:0011839)5.48968077
9Elevated erythrocyte sedimentation rate (HP:0003565)5.28733818
10Stomatitis (HP:0010280)5.24366923
11Granulocytopenia (HP:0001913)5.08546664
12Eczematoid dermatitis (HP:0000976)5.03414804
13IgG deficiency (HP:0004315)4.95868557
14Abnormality of T cells (HP:0002843)4.68023567
15Increased IgE level (HP:0003212)4.67737193
16Panhypogammaglobulinemia (HP:0003139)4.65442853
17Autoimmune thrombocytopenia (HP:0001973)4.59751810
18Eosinophilia (HP:0001880)4.59713166
19Recurrent fungal infections (HP:0002841)4.46765868
20Recurrent viral infections (HP:0004429)4.45463885
21Thyroiditis (HP:0100646)4.30843609
22Abnormality of eosinophils (HP:0001879)3.94578832
23Lymphopenia (HP:0001888)3.86413558
24Abnormality of cells of the lymphoid lineage (HP:0012140)3.72730438
25Hypergammaglobulinemia (HP:0010702)3.66744713
26IgM deficiency (HP:0002850)3.64639241
27Abnormality of T cell physiology (HP:0011840)3.58095637
28Hypoplasia of the thymus (HP:0000778)3.55015357
29Encephalitis (HP:0002383)3.36381723
30Abnormal delayed hypersensitivity skin test (HP:0002963)3.31034196
31Leukocytosis (HP:0001974)3.27285116
32Meningitis (HP:0001287)3.23163139
33Chronic diarrhea (HP:0002028)3.05502052
34Slow saccadic eye movements (HP:0000514)3.05421697
35Mesangial abnormality (HP:0001966)3.02140567
36Aplasia/Hypoplasia of the thymus (HP:0010515)2.90242973
37Lymphoma (HP:0002665)2.88919927
38Chronic obstructive pulmonary disease (HP:0006510)2.86312529
39Obstructive lung disease (HP:0006536)2.86312529
40Hypoproteinemia (HP:0003075)2.82027867
41Myositis (HP:0100614)2.75030316
42Vasculitis (HP:0002633)2.71622650
43Recurrent bronchitis (HP:0002837)2.70907504
44Acute hepatic failure (HP:0006554)2.69871880
45Abnormality of the columella (HP:0009929)2.69029433
46IgA deficiency (HP:0002720)2.66712750
47Recurrent abscess formation (HP:0002722)2.66224222
48Chronic mucocutaneous candidiasis (HP:0002728)2.64641716
49Recurrent cutaneous fungal infections (HP:0011370)2.64641716
50Joint swelling (HP:0001386)2.58042160
51Retrobulbar optic neuritis (HP:0100654)2.49326879
52Optic neuritis (HP:0100653)2.49326879
53Gastrointestinal infarctions (HP:0005244)2.42701777
54Hypochromic anemia (HP:0001931)2.38241474
55Abnormality of the thymus (HP:0000777)2.28780825
56Aplastic anemia (HP:0001915)2.28373653
57Pancytopenia (HP:0001876)2.27804498
58Abnormality of the fingertips (HP:0001211)2.26848028
59Oral leukoplakia (HP:0002745)2.26017681
60Orchitis (HP:0100796)2.25174684
61Spontaneous hematomas (HP:0007420)2.23712150
62Abnormality of macrophages (HP:0004311)2.17173656
63Keratoconjunctivitis sicca (HP:0001097)2.13362830
64Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.06339167
65Inflammation of the large intestine (HP:0002037)2.06198540
66Mediastinal lymphadenopathy (HP:0100721)2.04572901
67Gastrointestinal inflammation (HP:0004386)2.03587235
68Chest pain (HP:0100749)2.02782605
69Keratoconjunctivitis (HP:0001096)2.02331865
70Recurrent otitis media (HP:0000403)1.98840829
71Cellular immunodeficiency (HP:0005374)1.97999378
72Pulmonary infiltrates (HP:0002113)1.96381148
73Verrucae (HP:0200043)1.95125828
74Papilloma (HP:0012740)1.95125828
75Abnormality of the prostate (HP:0008775)1.92868452
76Pustule (HP:0200039)1.92839686
77Petechiae (HP:0000967)1.89369850
78Agammaglobulinemia (HP:0004432)1.87697210
79Basal ganglia calcification (HP:0002135)1.85684894
80Hepatitis (HP:0012115)1.84629608
81Recurrent bacterial skin infections (HP:0005406)1.84607666
82Pulmonary embolism (HP:0002204)1.83823241
83Hemoptysis (HP:0002105)1.83631529
84Gangrene (HP:0100758)1.83292990
85Microcytic anemia (HP:0001935)1.82062538
86Basal cell carcinoma (HP:0002671)1.81545472
87Birth length less than 3rd percentile (HP:0003561)1.79128215
88Recurrent skin infections (HP:0001581)1.72356276
89Recurrent sinusitis (HP:0011108)1.71935754
90Papilledema (HP:0001085)1.71683272
91Prolonged bleeding time (HP:0003010)1.70538031
92Fatigue (HP:0012378)1.69564119
93Recurrent gram-negative bacterial infections (HP:0005420)1.68998039
94Hypochromic microcytic anemia (HP:0004840)1.67831193
95Urticaria (HP:0001025)1.67326815
96Deep palmar crease (HP:0006191)1.66904846
97Epistaxis (HP:0000421)1.64957016
98Sepsis (HP:0100806)1.64386138
99Neutropenia (HP:0001875)1.64357031
100Bronchitis (HP:0012387)1.60096578

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ZAP705.30163676
2MAP4K14.96475533
3TXK4.47705736
4KDR3.19618788
5SMG13.06559378
6NLK2.53801473
7TESK22.52891493
8ITK2.42548640
9MAP3K102.39631454
10RIPK42.15880668
11GRK61.99467354
12MARK31.86201254
13BTK1.83691039
14MAPK111.82318372
15TNK21.71666515
16SYK1.71211910
17FES1.67602551
18ICK1.67224986
19TYK21.62538349
20PASK1.52893613
21LCK1.50430663
22PRPF4B1.30795248
23CDK121.30474640
24SCYL21.28663356
25CSK1.22043114
26FGFR41.20447889
27TAOK31.19933151
28CLK11.19540123
29FGFR21.19265121
30CDC71.18456177
31IKBKE1.15003939
32MAP3K111.14972125
33PRKCQ1.14836720
34JAK21.10452547
35HCK1.09291737
36TEC1.08776272
37CDK41.08746368
38TLK11.08544804
39MAP3K131.07914479
40TAOK11.07392973
41STK101.04952726
42SIK31.04772073
43FGFR31.03049177
44CDK81.02971259
45CAMKK11.01197750
46VRK20.97728836
47JAK30.96902914
48CAMKK20.91958221
49LYN0.91476750
50BLK0.89044023
51SIK20.86095916
52RPS6KA40.84176411
53MAP3K140.83983893
54TAF10.82123570
55DAPK10.75761239
56MAP3K70.74865690
57MST40.74398086
58PDGFRB0.74141858
59TAOK20.72794331
60MAP3K10.72358379
61PIM10.72047436
62MAP3K30.68427094
63IRAK40.67653886
64JAK10.66529389
65HIPK20.64025883
66TRIB30.61927208
67CDK70.61179814
68MAP2K30.59154336
69NEK20.57367700
70MELK0.56589857
71TYRO30.54410255
72ARAF0.52425381
73WEE10.51138241
74MAP3K120.51062831
75PKN20.51000763
76TESK10.48022721
77MAPKAPK20.47269604
78LRRK20.44915508
79MAPK120.43927331
80PLK40.42959194
81PDK10.41398634
82WNK10.40331580
83CSNK1G30.40231869
84VRK10.38073193
85RAF10.34488304
86CSNK1A1L0.33830441
87MAP3K80.33754149
88ATR0.30495592
89BRD40.29794590
90STK40.28264659
91NTRK20.27808152
92RPS6KC10.26327105
93RPS6KL10.26327105
94FYN0.26036209
95PRKCH0.24474599
96KSR20.24307831
97STK160.23900735
98MAP3K50.21252335
99CDK140.21246310
100RET0.21106999

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.94418969
2T cell receptor signaling pathway_Homo sapiens_hsa046604.19570169
3DNA replication_Homo sapiens_hsa030303.78522758
4Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.92786142
5Allograft rejection_Homo sapiens_hsa053302.72520854
6Measles_Homo sapiens_hsa051622.68423977
7Hematopoietic cell lineage_Homo sapiens_hsa046402.44815768
8Autoimmune thyroid disease_Homo sapiens_hsa053202.35944516
9Graft-versus-host disease_Homo sapiens_hsa053322.34877335
10Proteasome_Homo sapiens_hsa030502.25693995
11Fc epsilon RI signaling pathway_Homo sapiens_hsa046642.25481889
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.01224077
13NF-kappa B signaling pathway_Homo sapiens_hsa040641.82735746
14Mismatch repair_Homo sapiens_hsa034301.80941602
15Antigen processing and presentation_Homo sapiens_hsa046121.76356361
16Type I diabetes mellitus_Homo sapiens_hsa049401.71792584
17Jak-STAT signaling pathway_Homo sapiens_hsa046301.69678355
18Herpes simplex infection_Homo sapiens_hsa051681.69137764
19Osteoclast differentiation_Homo sapiens_hsa043801.63646948
20Acute myeloid leukemia_Homo sapiens_hsa052211.60914335
21Non-small cell lung cancer_Homo sapiens_hsa052231.59134216
22Base excision repair_Homo sapiens_hsa034101.50611317
23Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.50212661
24B cell receptor signaling pathway_Homo sapiens_hsa046621.43154795
25Hepatitis B_Homo sapiens_hsa051611.39577320
26Spliceosome_Homo sapiens_hsa030401.39060231
27Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.32337743
28Malaria_Homo sapiens_hsa051441.28706990
29Cell cycle_Homo sapiens_hsa041101.25752500
30Chronic myeloid leukemia_Homo sapiens_hsa052201.24338341
31RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.23753345
32Leishmaniasis_Homo sapiens_hsa051401.18790124
33African trypanosomiasis_Homo sapiens_hsa051431.16605458
34Viral myocarditis_Homo sapiens_hsa054161.16097095
35Intestinal immune network for IgA production_Homo sapiens_hsa046721.13190815
36HTLV-I infection_Homo sapiens_hsa051661.09356202
37Nucleotide excision repair_Homo sapiens_hsa034201.01538529
38Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.00226722
39Toll-like receptor signaling pathway_Homo sapiens_hsa046200.95844281
40Pancreatic cancer_Homo sapiens_hsa052120.94735922
41Thyroid cancer_Homo sapiens_hsa052160.89651050
42Pyrimidine metabolism_Homo sapiens_hsa002400.87934484
43Epstein-Barr virus infection_Homo sapiens_hsa051690.87279765
44Chemokine signaling pathway_Homo sapiens_hsa040620.86666527
45Viral carcinogenesis_Homo sapiens_hsa052030.84721076
46Rheumatoid arthritis_Homo sapiens_hsa053230.83865619
47Colorectal cancer_Homo sapiens_hsa052100.83242712
48Ribosome_Homo sapiens_hsa030100.82823063
49Glioma_Homo sapiens_hsa052140.82331322
50Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.81124628
51Influenza A_Homo sapiens_hsa051640.80310522
52mRNA surveillance pathway_Homo sapiens_hsa030150.78673692
53Shigellosis_Homo sapiens_hsa051310.77931086
54Tuberculosis_Homo sapiens_hsa051520.77872423
55Regulation of autophagy_Homo sapiens_hsa041400.77739075
56TNF signaling pathway_Homo sapiens_hsa046680.76404248
57Homologous recombination_Homo sapiens_hsa034400.74798474
58Non-homologous end-joining_Homo sapiens_hsa034500.73866917
59Apoptosis_Homo sapiens_hsa042100.72353364
60Toxoplasmosis_Homo sapiens_hsa051450.71386631
61Endometrial cancer_Homo sapiens_hsa052130.70799406
62Prostate cancer_Homo sapiens_hsa052150.68240759
63Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.66145227
64NOD-like receptor signaling pathway_Homo sapiens_hsa046210.63063611
65Salmonella infection_Homo sapiens_hsa051320.62433319
66Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.61736931
67Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.59658501
68Phosphatidylinositol signaling system_Homo sapiens_hsa040700.58168221
69VEGF signaling pathway_Homo sapiens_hsa043700.56156566
70Olfactory transduction_Homo sapiens_hsa047400.54998228
71Leukocyte transendothelial migration_Homo sapiens_hsa046700.54378909
72Pertussis_Homo sapiens_hsa051330.51555851
73One carbon pool by folate_Homo sapiens_hsa006700.51362652
74Fanconi anemia pathway_Homo sapiens_hsa034600.50908418
75Hepatitis C_Homo sapiens_hsa051600.50391935
76Asthma_Homo sapiens_hsa053100.49130318
77Long-term potentiation_Homo sapiens_hsa047200.47588113
78RNA transport_Homo sapiens_hsa030130.46555231
79Systemic lupus erythematosus_Homo sapiens_hsa053220.46208575
80Ras signaling pathway_Homo sapiens_hsa040140.44980002
81Phototransduction_Homo sapiens_hsa047440.44883500
82Prolactin signaling pathway_Homo sapiens_hsa049170.44599317
83Sphingolipid signaling pathway_Homo sapiens_hsa040710.43508305
84Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.41575550
85Staphylococcus aureus infection_Homo sapiens_hsa051500.40946023
86Neurotrophin signaling pathway_Homo sapiens_hsa047220.37136484
87Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.36425733
88Platelet activation_Homo sapiens_hsa046110.32696514
89Transcriptional misregulation in cancer_Homo sapiens_hsa052020.29330672
90Legionellosis_Homo sapiens_hsa051340.28822836
91RNA degradation_Homo sapiens_hsa030180.26348128
92Choline metabolism in cancer_Homo sapiens_hsa052310.25790624
93FoxO signaling pathway_Homo sapiens_hsa040680.25430087
94Alcoholism_Homo sapiens_hsa050340.24748433
95RNA polymerase_Homo sapiens_hsa030200.23124415
96Purine metabolism_Homo sapiens_hsa002300.21737782
97mTOR signaling pathway_Homo sapiens_hsa041500.19517523
98SNARE interactions in vesicular transport_Homo sapiens_hsa041300.19420600
99MicroRNAs in cancer_Homo sapiens_hsa052060.19145266
100Endocytosis_Homo sapiens_hsa041440.17024959

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