TRBV12-1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)9.04177783
2positive regulation of natural killer cell mediated immunity (GO:0002717)9.04177783
3activated T cell proliferation (GO:0050798)8.93662461
4positive regulation of response to tumor cell (GO:0002836)8.63959748
5positive regulation of immune response to tumor cell (GO:0002839)8.63959748
6regulation of immune response to tumor cell (GO:0002837)8.63959748
7regulation of response to tumor cell (GO:0002834)8.63959748
8regulation of natural killer cell mediated cytotoxicity (GO:0042269)8.12801744
9regulation of natural killer cell mediated immunity (GO:0002715)8.12801744
10negative T cell selection (GO:0043383)7.96471132
11regulation of isotype switching to IgG isotypes (GO:0048302)7.68087155
12negative thymic T cell selection (GO:0045060)7.32946799
13positive regulation of gamma-delta T cell activation (GO:0046645)7.02978375
14antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)7.02707003
15antigen processing and presentation of endogenous peptide antigen (GO:0002483)7.02707003
16positive thymic T cell selection (GO:0045059)6.91585997
17positive T cell selection (GO:0043368)6.75918311
18positive regulation of leukocyte mediated cytotoxicity (GO:0001912)6.47030337
19thymic T cell selection (GO:0045061)6.30036379
20regulation of gamma-delta T cell differentiation (GO:0045586)5.94422912
21positive regulation of cell killing (GO:0031343)5.89652419
22antigen processing and presentation of endogenous antigen (GO:0019883)5.76160842
23regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)5.72979188
24T cell selection (GO:0045058)5.68893093
25regulation of leukocyte mediated cytotoxicity (GO:0001910)5.63398367
26positive regulation of B cell mediated immunity (GO:0002714)5.42548583
27positive regulation of immunoglobulin mediated immune response (GO:0002891)5.42548583
28response to interleukin-15 (GO:0070672)5.36109338
29positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.31328750
30regulation of T cell tolerance induction (GO:0002664)5.29284857
31positive regulation of alpha-beta T cell proliferation (GO:0046641)5.24642394
32regulation of gamma-delta T cell activation (GO:0046643)5.22144819
33T cell migration (GO:0072678)5.19931651
34positive regulation of interleukin-2 biosynthetic process (GO:0045086)5.18260209
35regulation of cell killing (GO:0031341)5.12361042
36positive regulation of isotype switching (GO:0045830)5.04159302
37T cell costimulation (GO:0031295)5.01711643
38cellular response to interleukin-15 (GO:0071350)4.93847335
39regulation of interleukin-2 biosynthetic process (GO:0045076)4.93717014
40lymphocyte costimulation (GO:0031294)4.91047736
41regulation of alpha-beta T cell proliferation (GO:0046640)4.88622077
42regulation of immunoglobulin mediated immune response (GO:0002889)4.74544486
43T cell receptor signaling pathway (GO:0050852)4.65066591
44leukocyte aggregation (GO:0070486)4.61426702
45positive regulation of lymphocyte mediated immunity (GO:0002708)4.57834410
46regulation of B cell mediated immunity (GO:0002712)4.57466146
47positive regulation of humoral immune response (GO:0002922)4.50604439
48regulation of regulatory T cell differentiation (GO:0045589)4.37148971
49T cell proliferation (GO:0042098)4.25044332
50positive regulation of tolerance induction (GO:0002645)4.22718787
51interferon-gamma production (GO:0032609)4.22197709
52negative regulation of cell killing (GO:0031342)4.20493401
53negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.20493401
54positive regulation of DNA recombination (GO:0045911)4.18461558
55regulation of isotype switching (GO:0045191)4.17551764
56positive regulation of immunoglobulin production (GO:0002639)4.14415982
57regulation of interleukin-12 biosynthetic process (GO:0045075)4.13790297
58lymphocyte migration (GO:0072676)3.96768917
59regulation of lymphocyte mediated immunity (GO:0002706)3.93180206
60regulation of B cell receptor signaling pathway (GO:0050855)3.92880635
61regulation of T cell receptor signaling pathway (GO:0050856)3.91514626
62positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.89849684
63antigen receptor-mediated signaling pathway (GO:0050851)3.88203837
64cellular response to interleukin-4 (GO:0071353)3.86235666
65positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.85825528
66positive regulation of leukocyte mediated immunity (GO:0002705)3.84269557
67positive regulation of T cell chemotaxis (GO:0010820)3.80922372
68regulation of T cell chemotaxis (GO:0010819)3.80922372
69T cell homeostasis (GO:0043029)3.74324585
70regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.71617863
71regulation of tolerance induction (GO:0002643)3.67645376
72regulation of immunoglobulin production (GO:0002637)3.66557095
73antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.65703848
74T cell mediated immunity (GO:0002456)3.64465212
75mast cell activation (GO:0045576)3.56472054
76negative regulation of T cell receptor signaling pathway (GO:0050860)3.55434986
77negative regulation of interleukin-2 production (GO:0032703)3.46462137
78negative regulation of T cell mediated immunity (GO:0002710)3.42348205
79T cell activation (GO:0042110)3.39349136
80response to interleukin-4 (GO:0070670)3.38117438
81positive regulation of T cell cytokine production (GO:0002726)3.36898101
82antigen processing and presentation via MHC class Ib (GO:0002475)3.34610288
83myeloid dendritic cell differentiation (GO:0043011)3.33877006
84myeloid dendritic cell activation (GO:0001773)3.29991311
85negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.26875578
86negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.26072258
87positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.25603149
88regulation of interleukin-2 production (GO:0032663)3.20285001
89positive regulation of interleukin-2 production (GO:0032743)3.20104842
90positive regulation of response to biotic stimulus (GO:0002833)3.16506589
91T cell differentiation (GO:0030217)3.15127534
92natural killer cell activation (GO:0030101)3.14318482
93negative regulation of lymphocyte mediated immunity (GO:0002707)3.12592856
94positive regulation of calcium-mediated signaling (GO:0050850)3.09713820
95regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.09458003
96Arp2/3 complex-mediated actin nucleation (GO:0034314)3.06600486
97positive regulation of T cell mediated cytotoxicity (GO:0001916)3.02081195
98regulation of leukocyte mediated immunity (GO:0002703)3.01238316
99regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.98497417
100regulation of lymphocyte chemotaxis (GO:1901623)2.95793158

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse6.40168365
2E2F7_22180533_ChIP-Seq_HELA_Human6.11191836
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.60661023
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.29118797
5STAT4_19710469_ChIP-ChIP_TH1__Mouse4.22033302
6IRF8_22096565_ChIP-ChIP_GC-B_Human3.77478308
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.69996008
8MYC_22102868_ChIP-Seq_BL_Human3.63739264
9STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.47219815
10MYB_26560356_Chip-Seq_TH2_Human3.22993917
11RUNX_20019798_ChIP-Seq_JUKART_Human3.10255296
12MAF_26560356_Chip-Seq_TH1_Human2.96445327
13EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.91295420
14FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.79985499
15EGR1_19374776_ChIP-ChIP_THP-1_Human2.77535161
16UTX_26944678_Chip-Seq_JUKART_Human2.77024451
17MYB_26560356_Chip-Seq_TH1_Human2.61645116
18MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.56158606
19IRF8_21731497_ChIP-ChIP_J774_Mouse2.44800572
20SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.44084471
21RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.38501454
22VDR_21846776_ChIP-Seq_THP-1_Human2.26082160
23MAF_26560356_Chip-Seq_TH2_Human2.25155261
24NOTCH1_21737748_ChIP-Seq_TLL_Human2.16151229
25NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.13529704
26GATA3_27048872_Chip-Seq_THYMUS_Human2.12599912
27BP1_19119308_ChIP-ChIP_Hs578T_Human2.11379215
28FOXM1_23109430_ChIP-Seq_U2OS_Human2.08056263
29SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.94487382
30KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.85474306
31E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.82756928
32FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.74707758
33NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.74686921
34RUNX1_22412390_ChIP-Seq_EML_Mouse1.70928550
35SPI1_23547873_ChIP-Seq_NB4_Human1.66343575
36KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.65396694
37MYB_21317192_ChIP-Seq_ERMYB_Mouse1.63264440
38VDR_24763502_ChIP-Seq_THP-1_Human1.61746947
39FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.57875424
40KDM2B_26808549_Chip-Seq_DND41_Human1.57580308
41TCF7_22412390_ChIP-Seq_EML_Mouse1.55245373
42RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.54741704
43TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.53980411
44MYC_18555785_ChIP-Seq_MESCs_Mouse1.48722549
45SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.47818613
46ELF1_17652178_ChIP-ChIP_JURKAT_Human1.43711506
47SRY_22984422_ChIP-ChIP_TESTIS_Rat1.39981316
48NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.39232333
49E2F4_17652178_ChIP-ChIP_JURKAT_Human1.38465967
50RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.36286097
51MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.33424438
52SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.30490900
53CIITA_25753668_ChIP-Seq_RAJI_Human1.23025847
54IRF8_27001747_Chip-Seq_BMDM_Mouse1.21567479
55KDM2B_26808549_Chip-Seq_SUP-B15_Human1.20585899
56MYC_19079543_ChIP-ChIP_MESCs_Mouse1.18701770
57GATA3_26560356_Chip-Seq_TH2_Human1.18552256
58THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.18270167
59VDR_23849224_ChIP-Seq_CD4+_Human1.17876278
60XRN2_22483619_ChIP-Seq_HELA_Human1.13461997
61LXR_22292898_ChIP-Seq_THP-1_Human1.11095674
62SMAD_19615063_ChIP-ChIP_OVARY_Human1.08854495
63ELK3_25401928_ChIP-Seq_HUVEC_Human1.07625796
64BRD4_27068464_Chip-Seq_AML-cells_Mouse1.07449737
65SPI1_23127762_ChIP-Seq_K562_Human1.04346094
66SCL_19346495_ChIP-Seq_HPC-7_Human1.02560966
67KDM2B_26808549_Chip-Seq_JURKAT_Human1.01415506
68CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99294900
69FOXP3_21729870_ChIP-Seq_TREG_Human0.98515517
70SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.98088305
71MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.95818859
72GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.95216658
73GATA2_22383799_ChIP-Seq_G1ME_Mouse0.95079420
74ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.94773203
75SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.92422737
76CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.92107481
77CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91437237
78VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.90479781
79EGR1_19032775_ChIP-ChIP_M12_Human0.90281533
80ERG_20887958_ChIP-Seq_HPC-7_Mouse0.88272990
81PU_27001747_Chip-Seq_BMDM_Mouse0.88170837
82NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.88127421
83LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.86497121
84BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.84680164
85TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.84034686
86RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82906237
87PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.82417720
88CTCF_21964334_ChIP-Seq_BJAB-B_Human0.81933799
89CTCF_27219007_Chip-Seq_ERYTHROID_Human0.81745646
90ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.81078763
91MYC_18358816_ChIP-ChIP_MESCs_Mouse0.80807502
92PU.1_20513432_ChIP-Seq_Bcells_Mouse0.80032016
93GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.79501231
94TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.77624389
95GABP_17652178_ChIP-ChIP_JURKAT_Human0.76829725
96SPI1_20517297_ChIP-Seq_HL60_Human0.76769834
97EST1_17652178_ChIP-ChIP_JURKAT_Human0.75656009
98CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.75393880
99FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.74525495
100CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.73270696

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to6.24723872
2MP0003763_abnormal_thymus_physiology5.45627813
3MP0001835_abnormal_antigen_presentation3.93871360
4MP0002166_altered_tumor_susceptibility3.65083081
5MP0009785_altered_susceptibility_to3.41550656
6MP0006082_CNS_inflammation3.41195614
7MP0009333_abnormal_splenocyte_physiolog3.35052419
8MP0000685_abnormal_immune_system3.22300343
9MP0002006_tumorigenesis2.97985675
10MP0001800_abnormal_humoral_immune2.92383632
11MP0005000_abnormal_immune_tolerance2.90030413
12MP0002420_abnormal_adaptive_immunity2.83955171
13MP0002398_abnormal_bone_marrow2.82576047
14MP0001819_abnormal_immune_cell2.77948715
15MP0003300_gastrointestinal_ulcer2.71694312
16MP0002723_abnormal_immune_serum2.69165244
17MP0005025_abnormal_response_to2.68829352
18MP0000703_abnormal_thymus_morphology2.63835803
19MP0002405_respiratory_system_inflammati2.56900645
20MP0003724_increased_susceptibility_to2.55760298
21MP0003436_decreased_susceptibility_to2.55519840
22MP0000716_abnormal_immune_system2.43685527
23MP0005387_immune_system_phenotype2.39315456
24MP0001790_abnormal_immune_system2.39315456
25MP0002933_joint_inflammation2.30681495
26MP0002722_abnormal_immune_system2.29589720
27MP0002452_abnormal_antigen_presenting2.19927264
28MP0000689_abnormal_spleen_morphology2.13462376
29MP0001873_stomach_inflammation2.01704902
30MP0003866_abnormal_defecation2.00066270
31MP0002429_abnormal_blood_cell1.98671530
32MP0010155_abnormal_intestine_physiology1.97155104
33MP0002396_abnormal_hematopoietic_system1.96428801
34MP0004947_skin_inflammation1.85459280
35MP0000858_altered_metastatic_potential1.75228328
36MP0003448_altered_tumor_morphology1.70221781
37MP0002148_abnormal_hypersensitivity_rea1.68426279
38MP0001845_abnormal_inflammatory_respons1.68012488
39MP0002132_abnormal_respiratory_system1.62639962
40MP0002419_abnormal_innate_immunity1.60700152
41MP0001853_heart_inflammation1.46014134
42MP0005464_abnormal_platelet_physiology1.44533267
43MP0004510_myositis1.42139797
44MP0000604_amyloidosis1.17500770
45MP0000465_gastrointestinal_hemorrhage1.13406862
46MP0004957_abnormal_blastocyst_morpholog1.13124070
47MP0002019_abnormal_tumor_incidence1.12666961
48MP0010234_abnormal_vibrissa_follicle1.09732913
49MP0003303_peritoneal_inflammation1.09503042
50MP0001533_abnormal_skeleton_physiology1.09200292
51MP0008469_abnormal_protein_level1.08056909
52MP0003693_abnormal_embryo_hatching1.06298779
53MP0001958_emphysema1.00619762
54MP0004808_abnormal_hematopoietic_stem0.99327381
55MP0010352_gastrointestinal_tract_polyps0.98704744
56MP0008057_abnormal_DNA_replication0.96290191
57MP0005310_abnormal_salivary_gland0.92686288
58MP0003077_abnormal_cell_cycle0.91111528
59MP0003045_fibrosis0.89996913
60MP0004782_abnormal_surfactant_physiolog0.88940846
61MP0009763_increased_sensitivity_to0.86651950
62MP0005023_abnormal_wound_healing0.86576714
63MP0005166_decreased_susceptibility_to0.73448618
64MP0004381_abnormal_hair_follicle0.73336286
65MP0000490_abnormal_crypts_of0.70654596
66MP0001851_eye_inflammation0.67474930
67MP0005360_urolithiasis0.66830048
68MP0005397_hematopoietic_system_phenotyp0.65875039
69MP0001545_abnormal_hematopoietic_system0.65875039
70MP0002822_catalepsy0.65472368
71MP0000609_abnormal_liver_physiology0.64806463
72MP0000920_abnormal_myelination0.63351201
73MP0002998_abnormal_bone_remodeling0.61468201
74MP0010094_abnormal_chromosome_stability0.60012246
75MP0002693_abnormal_pancreas_physiology0.58669958
76MP0001243_abnormal_dermal_layer0.58283241
77MP0002089_abnormal_postnatal_growth/wei0.53346419
78MP0002136_abnormal_kidney_physiology0.52067920
79MP0008961_abnormal_basal_metabolism0.52043801
80MP0005584_abnormal_enzyme/coenzyme_acti0.51535552
81MP0009765_abnormal_xenobiotic_induced0.51497051
82MP0010307_abnormal_tumor_latency0.51465135
83MP0003172_abnormal_lysosome_physiology0.48570515
84MP0008873_increased_physiological_sensi0.47563137
85MP0002083_premature_death0.46558332
86MP0001348_abnormal_lacrimal_gland0.46223170
87MP0000477_abnormal_intestine_morphology0.45872071
88MP0005451_abnormal_body_composition0.44050259
89MP0003795_abnormal_bone_structure0.43103189
90MP0005075_abnormal_melanosome_morpholog0.42183819
91MP0000598_abnormal_liver_morphology0.41315463
92MP0005076_abnormal_cell_differentiation0.40409189
93MP0001730_embryonic_growth_arrest0.38691279
94MP0003075_altered_response_to0.37529466
95MP0001663_abnormal_digestive_system0.37524600
96MP0003453_abnormal_keratinocyte_physiol0.37416708
97MP0000249_abnormal_blood_vessel0.34472471
98MP0003111_abnormal_nucleus_morphology0.33965168
99MP0002138_abnormal_hepatobiliary_system0.33518527
100MP0001191_abnormal_skin_condition0.33399603

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)7.83836379
2Abnormality of T cell number (HP:0011839)7.56815697
3Nasal polyposis (HP:0100582)7.23456648
4Elevated erythrocyte sedimentation rate (HP:0003565)6.76063346
5Severe combined immunodeficiency (HP:0004430)6.36057123
6Chronic otitis media (HP:0000389)6.07813374
7Abnormality of the nasal mucosa (HP:0000433)6.00556287
8Combined immunodeficiency (HP:0005387)5.79621328
9Myositis (HP:0100614)5.48298849
10Eczematoid dermatitis (HP:0000976)5.06198484
11Panhypogammaglobulinemia (HP:0003139)5.03438295
12Recurrent bronchitis (HP:0002837)4.95682631
13Abnormality of T cells (HP:0002843)4.93435998
14Recurrent viral infections (HP:0004429)4.03908191
15Recurrent fungal infections (HP:0002841)4.01049924
16Stomatitis (HP:0010280)4.00086007
17Joint swelling (HP:0001386)3.98161484
18Pustule (HP:0200039)3.98154963
19IgG deficiency (HP:0004315)3.73017613
20Lymphopenia (HP:0001888)3.62646498
21Retrobulbar optic neuritis (HP:0100654)3.58962359
22Optic neuritis (HP:0100653)3.58962359
23Autoimmune hemolytic anemia (HP:0001890)3.55450656
24Abnormality of cells of the lymphoid lineage (HP:0012140)3.54357295
25Abnormality of eosinophils (HP:0001879)3.48625654
26Eosinophilia (HP:0001880)3.47299108
27Hypoplasia of the thymus (HP:0000778)3.32906029
28Recurrent abscess formation (HP:0002722)3.30375376
29Leukocytosis (HP:0001974)3.29627173
30Abnormality of B cell number (HP:0010975)3.27977427
31B lymphocytopenia (HP:0010976)3.27977427
32Orchitis (HP:0100796)3.15345094
33Increased IgM level (HP:0003496)3.06697412
34Chronic sinusitis (HP:0011109)3.01524480
35Abnormal delayed hypersensitivity skin test (HP:0002963)2.99476397
36Thyroiditis (HP:0100646)2.99295780
37Encephalitis (HP:0002383)2.97569574
38Granulocytopenia (HP:0001913)2.94401803
39Keratoconjunctivitis sicca (HP:0001097)2.92326601
40Hypergammaglobulinemia (HP:0010702)2.82951158
41Chronic mucocutaneous candidiasis (HP:0002728)2.77270544
42Recurrent cutaneous fungal infections (HP:0011370)2.77270544
43Meningitis (HP:0001287)2.76821695
44Abnormality of the fingertips (HP:0001211)2.74927355
45Hypoproteinemia (HP:0003075)2.69562363
46Bronchitis (HP:0012387)2.66525956
47Gastrointestinal infarctions (HP:0005244)2.62193909
48Keratoconjunctivitis (HP:0001096)2.58945733
49Hemoptysis (HP:0002105)2.57463317
50Lymphoma (HP:0002665)2.53671343
51Abnormality of T cell physiology (HP:0011840)2.51842869
52Chronic diarrhea (HP:0002028)2.47061693
53IgM deficiency (HP:0002850)2.45118408
54Recurrent bacterial skin infections (HP:0005406)2.39385442
55Pulmonary embolism (HP:0002204)2.38326977
56Arterial thrombosis (HP:0004420)2.37454197
57Pulmonary infiltrates (HP:0002113)2.35437767
58Recurrent skin infections (HP:0001581)2.34529229
59Mediastinal lymphadenopathy (HP:0100721)2.32725068
60Thrombocytosis (HP:0001894)2.32525666
61Vasculitis (HP:0002633)2.27264352
62Trigonocephaly (HP:0000243)2.27206737
63Recurrent otitis media (HP:0000403)2.24524734
64Basal cell carcinoma (HP:0002671)2.18808832
65Frequent falls (HP:0002359)2.13734146
66Abnormality of oral frenula (HP:0000190)2.09119372
67Gangrene (HP:0100758)2.07560106
68Amyotrophic lateral sclerosis (HP:0007354)2.04329791
69Increased IgE level (HP:0003212)2.03581245
70Spontaneous hematomas (HP:0007420)2.03032372
71Hemiplegia (HP:0002301)2.00923751
72Recurrent gram-negative bacterial infections (HP:0005420)2.00546432
73Reduced subcutaneous adipose tissue (HP:0003758)1.99427659
74Obstructive lung disease (HP:0006536)1.98726235
75Chronic obstructive pulmonary disease (HP:0006510)1.98726235
76Bronchiectasis (HP:0002110)1.96101546
77Aplasia/Hypoplasia of the thymus (HP:0010515)1.95592649
78Recurrent sinusitis (HP:0011108)1.93908355
79Microcytic anemia (HP:0001935)1.92599944
80Abnormality of the pleura (HP:0002103)1.83105862
81Epistaxis (HP:0000421)1.75762188
82Interstitial pulmonary disease (HP:0006530)1.75428201
83Emphysema (HP:0002097)1.73456748
84Bicuspid aortic valve (HP:0001647)1.69413889
85Arthralgia (HP:0002829)1.69411349
86Abnormal platelet volume (HP:0011876)1.68834980
87Skin ulcer (HP:0200042)1.68191879
88Aplastic anemia (HP:0001915)1.67534763
89Anorexia (HP:0002039)1.67519200
90Inflammation of the large intestine (HP:0002037)1.67111770
91Amaurosis fugax (HP:0100576)1.66681076
92Petechiae (HP:0000967)1.65953873
93Prominent metopic ridge (HP:0005487)1.65710480
94Gastrointestinal inflammation (HP:0004386)1.62380711
95Periodontitis (HP:0000704)1.62094719
96Chest pain (HP:0100749)1.61966914
97Gingival bleeding (HP:0000225)1.61782321
98Diplopia (HP:0000651)1.61767675
99Abnormality of binocular vision (HP:0011514)1.61767675
100Abnormality of the endocardium (HP:0004306)1.61381093

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.61941993
2TXK5.05938427
3ITK4.26443261
4ZAP703.86302112
5FGFR43.58784699
6JAK32.91693061
7KDR2.73634466
8TYK22.64429685
9NME22.62712651
10LCK2.31286515
11CSK2.21887772
12IKBKE2.19219629
13JAK12.17467046
14MAP3K141.98261251
15STK101.95758208
16TBK11.86313138
17FGFR31.79041853
18PRKCH1.61660677
19MST41.58253124
20TRIB31.50257234
21GRK61.49892532
22BLK1.49593445
23SYK1.49587013
24EPHA31.48625946
25FGFR11.38413073
26BUB11.36679394
27EEF2K1.33940103
28TEC1.32982274
29PKN21.30898351
30MAP2K61.24954684
31CLK11.24719663
32NLK1.22395662
33HCK1.17719546
34MAP3K131.17099719
35TESK21.14219917
36LRRK21.06995309
37EPHB11.02225507
38CDC71.00141229
39FES0.97085130
40KIT0.95753918
41LYN0.95007918
42PRKCQ0.94396615
43TSSK60.90257328
44TAOK10.88096179
45BTK0.84761974
46MAP3K100.83426025
47JAK20.81469701
48SIK20.81043394
49MAP3K110.80586917
50RAF10.80279675
51MAP3K70.80179606
52SCYL20.79146461
53ALK0.76626206
54INSR0.71601594
55IKBKB0.69889208
56MELK0.66251885
57CSF1R0.62794378
58TYRO30.58941534
59PASK0.58233842
60FYN0.56893348
61MAP3K80.53524782
62PDK10.52270213
63PIM20.50200474
64PDGFRB0.47976123
65EGFR0.43598923
66FGFR20.43221245
67MAPK110.42001052
68CDK40.41025152
69ACVR1B0.40453888
70RPS6KB20.40224485
71TLK10.39962302
72MAP2K30.36471125
73CHUK0.36371744
74PIM10.36168613
75IGF1R0.33497858
76CDK80.31422405
77NTRK20.27294800
78SRC0.27210959
79RPS6KA40.25471097
80NEK20.25467430
81TAOK20.23481980
82PRPF4B0.22625293
83ILK0.22325071
84MARK30.21997186
85TNK20.21879112
86DAPK10.21265867
87SIK10.20180488
88MAP3K120.18845565
89PRKCD0.18292178
90GSK3A0.17909158
91AURKB0.17087845
92HIPK20.16809117
93TTN0.16704027
94ABL10.16005231
95KSR20.15593280
96CDK190.15237730
97MAPK90.14416945
98MAPK30.13652067
99ERN10.12426580
100TGFBR10.12406130

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053326.42007321
2Primary immunodeficiency_Homo sapiens_hsa053405.60391904
3T cell receptor signaling pathway_Homo sapiens_hsa046604.13210700
4Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046503.87756281
5Antigen processing and presentation_Homo sapiens_hsa046123.69526676
6Allograft rejection_Homo sapiens_hsa053303.51552774
7Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.99560844
8Type I diabetes mellitus_Homo sapiens_hsa049402.86057405
9Measles_Homo sapiens_hsa051622.50634405
10Hematopoietic cell lineage_Homo sapiens_hsa046402.37930402
11Autoimmune thyroid disease_Homo sapiens_hsa053202.09998165
12NF-kappa B signaling pathway_Homo sapiens_hsa040642.04206671
13Viral myocarditis_Homo sapiens_hsa054161.99905224
14Proteasome_Homo sapiens_hsa030501.96219838
15Ribosome_Homo sapiens_hsa030101.63430877
16Intestinal immune network for IgA production_Homo sapiens_hsa046721.48393889
17Leishmaniasis_Homo sapiens_hsa051401.47289537
18Jak-STAT signaling pathway_Homo sapiens_hsa046301.46970617
19DNA replication_Homo sapiens_hsa030301.44980584
20Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.41035316
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.39944241
22Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.30627293
23Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.29960004
24Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.25919640
25Shigellosis_Homo sapiens_hsa051311.23464173
26Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.17458543
27Chemokine signaling pathway_Homo sapiens_hsa040621.16271819
28HTLV-I infection_Homo sapiens_hsa051661.12717846
29Herpes simplex infection_Homo sapiens_hsa051681.11060371
30Osteoclast differentiation_Homo sapiens_hsa043801.10350941
31B cell receptor signaling pathway_Homo sapiens_hsa046621.06523207
32RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.97591031
33Hepatitis B_Homo sapiens_hsa051610.97330633
34Apoptosis_Homo sapiens_hsa042100.96945441
35Salmonella infection_Homo sapiens_hsa051320.94684538
36Leukocyte transendothelial migration_Homo sapiens_hsa046700.94672746
37Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.93208316
38Staphylococcus aureus infection_Homo sapiens_hsa051500.92016568
39Asthma_Homo sapiens_hsa053100.89821816
40Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.88227452
41Mismatch repair_Homo sapiens_hsa034300.81475299
42Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.80345183
43Spliceosome_Homo sapiens_hsa030400.79476959
44VEGF signaling pathway_Homo sapiens_hsa043700.76199320
45Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.73894404
46Rheumatoid arthritis_Homo sapiens_hsa053230.70524752
47Toxoplasmosis_Homo sapiens_hsa051450.70453185
48Cyanoamino acid metabolism_Homo sapiens_hsa004600.68352189
49Malaria_Homo sapiens_hsa051440.67959848
50Epstein-Barr virus infection_Homo sapiens_hsa051690.67802694
51Legionellosis_Homo sapiens_hsa051340.67158878
52Non-homologous end-joining_Homo sapiens_hsa034500.65959804
53Colorectal cancer_Homo sapiens_hsa052100.65417874
54Influenza A_Homo sapiens_hsa051640.64742390
55One carbon pool by folate_Homo sapiens_hsa006700.61698317
56TNF signaling pathway_Homo sapiens_hsa046680.58105898
57Pancreatic cancer_Homo sapiens_hsa052120.54260971
58Acute myeloid leukemia_Homo sapiens_hsa052210.52827551
59NOD-like receptor signaling pathway_Homo sapiens_hsa046210.51683637
60Viral carcinogenesis_Homo sapiens_hsa052030.51308806
61Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.45744745
62Nucleotide excision repair_Homo sapiens_hsa034200.44336026
63Platelet activation_Homo sapiens_hsa046110.42974107
64Pertussis_Homo sapiens_hsa051330.42053088
65Toll-like receptor signaling pathway_Homo sapiens_hsa046200.40954559
66Chronic myeloid leukemia_Homo sapiens_hsa052200.39294533
67AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.34958511
68Pentose phosphate pathway_Homo sapiens_hsa000300.32573346
69Base excision repair_Homo sapiens_hsa034100.31803766
70p53 signaling pathway_Homo sapiens_hsa041150.31583314
71Tuberculosis_Homo sapiens_hsa051520.31329219
72Hepatitis C_Homo sapiens_hsa051600.22982593
73Biosynthesis of amino acids_Homo sapiens_hsa012300.22794537
74RNA degradation_Homo sapiens_hsa030180.20571268
75Drug metabolism - other enzymes_Homo sapiens_hsa009830.20095241
76Pyrimidine metabolism_Homo sapiens_hsa002400.18684878
77Cell cycle_Homo sapiens_hsa041100.18299400
78Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.18090079
79Regulation of actin cytoskeleton_Homo sapiens_hsa048100.17490420
80RNA transport_Homo sapiens_hsa030130.16592008
81Prolactin signaling pathway_Homo sapiens_hsa049170.16297292
82Rap1 signaling pathway_Homo sapiens_hsa040150.16056542
83Neurotrophin signaling pathway_Homo sapiens_hsa047220.15488889
84Caffeine metabolism_Homo sapiens_hsa002320.13931258
85Adipocytokine signaling pathway_Homo sapiens_hsa049200.13706520
86HIF-1 signaling pathway_Homo sapiens_hsa040660.13431733
87Transcriptional misregulation in cancer_Homo sapiens_hsa052020.13262382
88Systemic lupus erythematosus_Homo sapiens_hsa053220.12902019
89Endocytosis_Homo sapiens_hsa041440.12173960
90Long-term potentiation_Homo sapiens_hsa047200.11010274
91Small cell lung cancer_Homo sapiens_hsa052220.10046422
92Adherens junction_Homo sapiens_hsa045200.08945083
93Amoebiasis_Homo sapiens_hsa051460.08638475
94Thyroid cancer_Homo sapiens_hsa052160.07461678
95Nitrogen metabolism_Homo sapiens_hsa009100.07006739
96African trypanosomiasis_Homo sapiens_hsa051430.05834075
97Insulin resistance_Homo sapiens_hsa049310.01586430
98Non-small cell lung cancer_Homo sapiens_hsa052230.00829070
99Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.00814431
100Sphingolipid signaling pathway_Homo sapiens_hsa04071-0.0013796

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