TRBV12-3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative T cell selection (GO:0043383)6.80860873
2positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)6.61807910
3positive T cell selection (GO:0043368)6.61673597
4regulation of B cell receptor signaling pathway (GO:0050855)5.75764903
5positive thymic T cell selection (GO:0045059)5.74586944
6negative thymic T cell selection (GO:0045060)5.36855486
7mucosal-associated lymphoid tissue development (GO:0048537)4.87428017
8Peyers patch development (GO:0048541)4.87428017
9positive regulation of granulocyte differentiation (GO:0030854)4.84670090
10T cell selection (GO:0045058)4.79600969
11negative regulation of B cell apoptotic process (GO:0002903)4.64282624
12deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.43729449
13purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)4.41477379
14thymic T cell selection (GO:0045061)4.40907318
15negative regulation of T cell apoptotic process (GO:0070233)4.39172499
16purine deoxyribonucleotide catabolic process (GO:0009155)4.32476192
17leukocyte aggregation (GO:0070486)4.26415289
18positive regulation of gamma-delta T cell activation (GO:0046645)4.22046551
19antigen processing and presentation of endogenous antigen (GO:0019883)4.17595239
20positive regulation of B cell differentiation (GO:0045579)4.14414091
21regulation of B cell differentiation (GO:0045577)4.09185373
22purine nucleotide salvage (GO:0032261)4.07384709
23deoxyribonucleoside triphosphate metabolic process (GO:0009200)4.01451391
24DNA deamination (GO:0045006)3.90384629
25positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.89135301
26negative regulation of lymphocyte apoptotic process (GO:0070229)3.87874273
27antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.84721396
28cellular response to interleukin-15 (GO:0071350)3.83420987
29regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.77582887
30negative regulation of thymocyte apoptotic process (GO:0070244)3.73160566
31regulation of T cell receptor signaling pathway (GO:0050856)3.72992905
32purine deoxyribonucleotide metabolic process (GO:0009151)3.64077574
33B cell mediated immunity (GO:0019724)3.63852361
34purine-containing compound salvage (GO:0043101)3.63743479
35negative regulation of phagocytosis (GO:0050765)3.63659499
36mature B cell differentiation involved in immune response (GO:0002313)3.62768822
37antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.62209034
38response to interleukin-15 (GO:0070672)3.61889598
39T cell migration (GO:0072678)3.60875488
40deoxyribose phosphate biosynthetic process (GO:0046385)3.51990708
412-deoxyribonucleotide biosynthetic process (GO:0009265)3.51990708
42regulation of gamma-delta T cell differentiation (GO:0045586)3.49591007
43positive regulation of alpha-beta T cell proliferation (GO:0046641)3.46952504
44response to interferon-beta (GO:0035456)3.45703807
45negative regulation of interleukin-12 production (GO:0032695)3.38938316
46immunoglobulin mediated immune response (GO:0016064)3.38426799
47regulation of interleukin-2 biosynthetic process (GO:0045076)3.35348787
48Arp2/3 complex-mediated actin nucleation (GO:0034314)3.32696080
49regulation of B cell apoptotic process (GO:0002902)3.29876890
50nucleotide salvage (GO:0043173)3.29332201
51* antigen receptor-mediated signaling pathway (GO:0050851)3.26226251
52deoxyribonucleotide catabolic process (GO:0009264)3.22368415
53B cell receptor signaling pathway (GO:0050853)3.19359388
54regulation of alpha-beta T cell proliferation (GO:0046640)3.17784752
55deoxyribose phosphate catabolic process (GO:0046386)3.17362499
56positive regulation of T cell differentiation in thymus (GO:0033089)3.16883576
57ribosomal small subunit assembly (GO:0000028)3.14875820
582-deoxyribonucleotide metabolic process (GO:0009394)3.12752455
59regulation of granulocyte differentiation (GO:0030852)3.11323626
60cytolysis (GO:0019835)3.10623043
61positive regulation of alpha-beta T cell activation (GO:0046635)3.10043791
62positive regulation of interleukin-4 production (GO:0032753)3.09760315
63positive regulation of interleukin-17 production (GO:0032740)3.08895912
64* T cell receptor signaling pathway (GO:0050852)3.08216256
65activated T cell proliferation (GO:0050798)3.07171377
66mast cell activation (GO:0045576)3.07162440
67CD4-positive, alpha-beta T cell activation (GO:0035710)3.06621765
68CD4-positive, alpha-beta T cell differentiation (GO:0043367)3.06210066
69cellular response to interleukin-4 (GO:0071353)3.04519569
70antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.03658527
71alpha-beta T cell differentiation (GO:0046632)3.03236653
72regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.02870624
73regulation of gamma-delta T cell activation (GO:0046643)3.01436896
74regulation of T cell apoptotic process (GO:0070232)2.96881125
75cell wall macromolecule catabolic process (GO:0016998)2.96850302
76deoxyribose phosphate metabolic process (GO:0019692)2.95769316
77hepatocyte apoptotic process (GO:0097284)2.95336268
78positive regulation of calcium-mediated signaling (GO:0050850)2.93859834
79alpha-beta T cell activation (GO:0046631)2.90521330
80negative regulation of cell killing (GO:0031342)2.89584427
81negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.89584427
82positive regulation of alpha-beta T cell differentiation (GO:0046638)2.86769397
83negative regulation of leukocyte apoptotic process (GO:2000107)2.86463150
84V(D)J recombination (GO:0033151)2.85348235
85regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.84009417
86regulation of alpha-beta T cell activation (GO:0046634)2.83678649
87* T cell costimulation (GO:0031295)2.82674174
88mature B cell differentiation (GO:0002335)2.82437140
89cell wall macromolecule metabolic process (GO:0044036)2.81333596
90pseudouridine synthesis (GO:0001522)2.79787849
91regulation of lymphocyte apoptotic process (GO:0070228)2.79246044
92* lymphocyte costimulation (GO:0031294)2.78933254
93regulation of interleukin-4 production (GO:0032673)2.78355803
94megakaryocyte development (GO:0035855)2.77741387
95histamine secretion (GO:0001821)2.76864026
96mast cell degranulation (GO:0043303)2.71889968
97mast cell activation involved in immune response (GO:0002279)2.71889968
98cytidine deamination (GO:0009972)2.70366585
99cytidine metabolic process (GO:0046087)2.70366585
100cytidine catabolic process (GO:0006216)2.70366585

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human6.42333455
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.68397514
3ELF1_17652178_ChIP-ChIP_JURKAT_Human4.17452791
4E2F7_22180533_ChIP-Seq_HELA_Human3.88244433
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.32848447
6MYB_26560356_Chip-Seq_TH2_Human3.18040995
7UTX_26944678_Chip-Seq_JUKART_Human2.83603986
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.70232776
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.63885710
10SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.58761735
11RUNX_20019798_ChIP-Seq_JUKART_Human2.58501975
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.50807857
13SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.50765137
14MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.47945000
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.45239746
16VDR_21846776_ChIP-Seq_THP-1_Human2.43585341
17SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.43441069
18RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.42092175
19MYB_26560356_Chip-Seq_TH1_Human2.36740851
20EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.34127112
21SCL_19346495_ChIP-Seq_HPC-7_Human2.22707832
22STAT4_19710469_ChIP-ChIP_TH1__Mouse2.21900674
23MYC_22102868_ChIP-Seq_BL_Human2.20318948
24SPI1_23547873_ChIP-Seq_NB4_Human2.12603038
25MAF_26560356_Chip-Seq_TH1_Human2.10500556
26TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.05236402
27STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.04976189
28FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.98090922
29VDR_24763502_ChIP-Seq_THP-1_Human1.97817189
30GATA3_27048872_Chip-Seq_THYMUS_Human1.96835494
31IRF8_21731497_ChIP-ChIP_J774_Mouse1.95548133
32MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.94401923
33JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.91621006
34FOXP3_21729870_ChIP-Seq_TREG_Human1.86865594
35MAF_26560356_Chip-Seq_TH2_Human1.84090098
36VDR_23849224_ChIP-Seq_CD4+_Human1.82085319
37E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.81136570
38HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.75588710
39LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.73645761
40FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.72046159
41CIITA_25753668_ChIP-Seq_RAJI_Human1.68578783
42EST1_17652178_ChIP-ChIP_JURKAT_Human1.66066388
43GABP_17652178_ChIP-ChIP_JURKAT_Human1.65330653
44ETS1_20019798_ChIP-Seq_JURKAT_Human1.61718258
45ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.55980846
46MYC_18358816_ChIP-ChIP_MESCs_Mouse1.55424714
47SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.55328209
48RUNX1_22412390_ChIP-Seq_EML_Mouse1.51453514
49GATA3_26560356_Chip-Seq_TH2_Human1.48085217
50EGR1_19374776_ChIP-ChIP_THP-1_Human1.41343706
51KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.40646107
52SRF_21415370_ChIP-Seq_HL-1_Mouse1.36225309
53HOXB4_20404135_ChIP-ChIP_EML_Mouse1.33611861
54LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.32671322
55HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.32029290
56CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.31608458
57NOTCH1_21737748_ChIP-Seq_TLL_Human1.31159369
58CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.30620511
59MYC_18555785_ChIP-Seq_MESCs_Mouse1.30580990
60E2F4_17652178_ChIP-ChIP_JURKAT_Human1.30352990
61BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.29849641
62RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.27648796
63MYB_21317192_ChIP-Seq_ERMYB_Mouse1.27500169
64BRD4_27068464_Chip-Seq_AML-cells_Mouse1.26854818
65SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.25373359
66GATA2_22383799_ChIP-Seq_G1ME_Mouse1.22650503
67SPI1_20517297_ChIP-Seq_HL60_Human1.21474119
68ELF1_20517297_ChIP-Seq_JURKAT_Human1.20285838
69CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.16577052
70GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.14382169
71BCL6_27268052_Chip-Seq_Bcells_Human1.14203231
72FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13400096
73ERG_20887958_ChIP-Seq_HPC-7_Mouse1.12692395
74KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.11202091
75SPI1_23127762_ChIP-Seq_K562_Human1.05425952
76GABP_19822575_ChIP-Seq_HepG2_Human1.04964187
77CREB1_15753290_ChIP-ChIP_HEK293T_Human1.03244122
78NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.02844712
79TCF7_22412390_ChIP-Seq_EML_Mouse1.02562120
80CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.01630127
81KDM2B_26808549_Chip-Seq_DND41_Human1.01251776
82IRF8_27001747_Chip-Seq_BMDM_Mouse1.00905767
83TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00086650
84GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.99844156
85KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.97862259
86MYC_19030024_ChIP-ChIP_MESCs_Mouse0.97622156
87PU.1_20513432_ChIP-Seq_Bcells_Mouse0.96633278
88HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.95824585
89FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.95251298
90PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.94744016
91CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.91200726
92MYC_19079543_ChIP-ChIP_MESCs_Mouse0.90515429
93YY1_22570637_ChIP-Seq_MALME-3M_Human0.90309603
94XRN2_22483619_ChIP-Seq_HELA_Human0.88852670
95CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.86265893
96ETS1_21867929_ChIP-Seq_TH2_Mouse0.84850899
97BCOR_27268052_Chip-Seq_Bcells_Human0.84027291
98P300_27268052_Chip-Seq_Bcells_Human0.83357411
99PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.83225972
100RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82916577

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002009_preneoplasia4.57830960
2MP0003763_abnormal_thymus_physiology4.45852956
3MP0001835_abnormal_antigen_presentation3.95389397
4MP0002166_altered_tumor_susceptibility3.86811149
5MP0005671_abnormal_response_to3.40928930
6MP0002396_abnormal_hematopoietic_system3.22089824
7MP0002006_tumorigenesis3.06330230
8MP0005000_abnormal_immune_tolerance2.87762622
9MP0003436_decreased_susceptibility_to2.83900420
10MP0001800_abnormal_humoral_immune2.56711711
11MP0002420_abnormal_adaptive_immunity2.56650251
12MP0000703_abnormal_thymus_morphology2.56313682
13MP0001819_abnormal_immune_cell2.49214689
14MP0009785_altered_susceptibility_to2.47982712
15MP0002398_abnormal_bone_marrow2.47682441
16MP0005025_abnormal_response_to2.43969109
17MP0009333_abnormal_splenocyte_physiolog2.35239391
18MP0002723_abnormal_immune_serum2.25948379
19MP0002148_abnormal_hypersensitivity_rea2.21896630
20MP0000716_abnormal_immune_system2.16911644
21MP0000685_abnormal_immune_system2.16806125
22MP0000689_abnormal_spleen_morphology2.14174029
23MP0002452_abnormal_antigen_presenting2.13344152
24MP0001790_abnormal_immune_system2.13287328
25MP0005387_immune_system_phenotype2.13287328
26MP0002722_abnormal_immune_system2.12714736
27MP0003724_increased_susceptibility_to2.00172329
28MP0005464_abnormal_platelet_physiology1.93580626
29MP0002405_respiratory_system_inflammati1.93070182
30MP0009697_abnormal_copulation1.91999109
31MP0002933_joint_inflammation1.87557868
32MP0002429_abnormal_blood_cell1.85205882
33MP0003806_abnormal_nucleotide_metabolis1.83848905
34MP0002419_abnormal_innate_immunity1.82223676
35MP0003787_abnormal_imprinting1.76751337
36MP0005075_abnormal_melanosome_morpholog1.68245992
37MP0003866_abnormal_defecation1.64474167
38MP0000465_gastrointestinal_hemorrhage1.62776090
39MP0010094_abnormal_chromosome_stability1.59653213
40MP0003300_gastrointestinal_ulcer1.55766194
41MP0010155_abnormal_intestine_physiology1.52713572
42MP0008058_abnormal_DNA_repair1.51803500
43MP0004185_abnormal_adipocyte_glucose1.50128500
44MP0008877_abnormal_DNA_methylation1.45135033
45MP0009278_abnormal_bone_marrow1.45123491
46MP0004808_abnormal_hematopoietic_stem1.42712443
47MP0009764_decreased_sensitivity_to1.40038395
48MP0001873_stomach_inflammation1.39038050
49MP0002019_abnormal_tumor_incidence1.31927085
50MP0001845_abnormal_inflammatory_respons1.29238083
51MP0000858_altered_metastatic_potential1.29014992
52MP0005397_hematopoietic_system_phenotyp1.27478796
53MP0001545_abnormal_hematopoietic_system1.27478796
54MP0006082_CNS_inflammation1.15287045
55MP0006072_abnormal_retinal_apoptosis1.13537097
56MP0000490_abnormal_crypts_of1.10208510
57MP0008057_abnormal_DNA_replication1.08341640
58MP0001533_abnormal_skeleton_physiology1.06304900
59MP0003448_altered_tumor_morphology1.06083768
60MP0005310_abnormal_salivary_gland1.02639713
61MP0001661_extended_life_span1.01594489
62MP0004381_abnormal_hair_follicle1.00440623
63MP0006036_abnormal_mitochondrial_physio0.99401190
64MP0001853_heart_inflammation0.97820280
65MP0006035_abnormal_mitochondrial_morpho0.96563301
66MP0004947_skin_inflammation0.94830872
67MP0008469_abnormal_protein_level0.92443836
68MP0008872_abnormal_physiological_respon0.90459214
69MP0009763_increased_sensitivity_to0.89911320
70MP0002638_abnormal_pupillary_reflex0.89049523
71MP0005084_abnormal_gallbladder_morpholo0.86883936
72MP0000372_irregular_coat_pigmentation0.83832634
73MP0003786_premature_aging0.83080678
74MP0008873_increased_physiological_sensi0.79075302
75MP0002132_abnormal_respiratory_system0.76424721
76MP0001764_abnormal_homeostasis0.76019066
77MP0008007_abnormal_cellular_replicative0.72800715
78MP0008961_abnormal_basal_metabolism0.71271360
79MP0003252_abnormal_bile_duct0.70244105
80MP0002877_abnormal_melanocyte_morpholog0.68185643
81MP0000313_abnormal_cell_death0.67427591
82MP0005645_abnormal_hypothalamus_physiol0.66589257
83MP0008260_abnormal_autophagy0.65803398
84MP0002693_abnormal_pancreas_physiology0.60033447
85MP0003303_peritoneal_inflammation0.58824988
86MP0003111_abnormal_nucleus_morphology0.57590614
87MP0005666_abnormal_adipose_tissue0.55587102
88MP0001851_eye_inflammation0.54492616
89MP0003077_abnormal_cell_cycle0.53636866
90MP0005584_abnormal_enzyme/coenzyme_acti0.53557004
91MP0005319_abnormal_enzyme/_coenzyme0.53125912
92MP0003693_abnormal_embryo_hatching0.51782252
93MP0003183_abnormal_peptide_metabolism0.51674222
94MP0002083_premature_death0.51307381
95MP0004142_abnormal_muscle_tone0.51275755
96MP0005451_abnormal_body_composition0.50713271
97MP0005083_abnormal_biliary_tract0.50407309
98MP0005266_abnormal_metabolism0.48477490
99MP0009765_abnormal_xenobiotic_induced0.47734326
100MP0008569_lethality_at_weaning0.45965015

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)7.25261289
2Autoimmune hemolytic anemia (HP:0001890)6.45745465
3Panhypogammaglobulinemia (HP:0003139)6.10812930
4Severe combined immunodeficiency (HP:0004430)5.98560752
5Agammaglobulinemia (HP:0004432)5.20814714
6Autoimmune thrombocytopenia (HP:0001973)5.15836726
7Combined immunodeficiency (HP:0005387)5.00330329
8B lymphocytopenia (HP:0010976)4.94552234
9Aplastic anemia (HP:0001915)4.94347169
10Abnormality of B cell number (HP:0010975)4.81518247
11Recurrent viral infections (HP:0004429)4.50956234
12Recurrent fungal infections (HP:0002841)4.46655978
13Recurrent cutaneous fungal infections (HP:0011370)4.35097533
14Chronic mucocutaneous candidiasis (HP:0002728)4.35097533
15Abnormal delayed hypersensitivity skin test (HP:0002963)4.12265934
16Abnormality of T cells (HP:0002843)4.06035182
17T lymphocytopenia (HP:0005403)3.99685598
18Increased IgE level (HP:0003212)3.96915194
19Myositis (HP:0100614)3.89610871
20Encephalitis (HP:0002383)3.84993439
21Increased IgM level (HP:0003496)3.84490591
22Abnormality of T cell physiology (HP:0011840)3.74413366
23Hypergammaglobulinemia (HP:0010702)3.68577438
24Abnormality of T cell number (HP:0011839)3.66139227
25Granulocytopenia (HP:0001913)3.66129544
26Eosinophilia (HP:0001880)3.58780400
27Meningitis (HP:0001287)3.47639211
28Thyroiditis (HP:0100646)3.46773590
29Thrombocytosis (HP:0001894)3.41206192
30Stomatitis (HP:0010280)3.40661232
31Abnormality of eosinophils (HP:0001879)3.20930395
32IgG deficiency (HP:0004315)3.19209227
33Eczematoid dermatitis (HP:0000976)3.12531274
34Microvesicular hepatic steatosis (HP:0001414)3.08274011
35Lymphopenia (HP:0001888)3.08254517
36Hypoplasia of the thymus (HP:0000778)3.00925594
37Leukocytosis (HP:0001974)2.90811200
38Abnormality of cells of the lymphoid lineage (HP:0012140)2.87128335
39Lymphoma (HP:0002665)2.68570142
40IgM deficiency (HP:0002850)2.66873326
41Acute hepatic failure (HP:0006554)2.65573949
42Hepatocellular necrosis (HP:0001404)2.59668107
43Orchitis (HP:0100796)2.57554002
44Aplasia/Hypoplasia of the thymus (HP:0010515)2.55362200
45Abnormality of the fingertips (HP:0001211)2.52550713
46Recurrent skin infections (HP:0001581)2.48536133
47Mesangial abnormality (HP:0001966)2.45118736
48Optic neuritis (HP:0100653)2.45055898
49Retrobulbar optic neuritis (HP:0100654)2.45055898
50Abnormality of macrophages (HP:0004311)2.42344257
51Acute lymphatic leukemia (HP:0006721)2.38827068
52Chronic obstructive pulmonary disease (HP:0006510)2.36154001
53Obstructive lung disease (HP:0006536)2.36154001
54Mitochondrial inheritance (HP:0001427)2.32633169
55Increased intramyocellular lipid droplets (HP:0012240)2.31784115
56Gastrointestinal inflammation (HP:0004386)2.31726627
57Hepatic necrosis (HP:0002605)2.31394467
58Colitis (HP:0002583)2.21653748
59Recurrent abscess formation (HP:0002722)2.21252160
60Skin rash (HP:0000988)2.18461015
61Pancytopenia (HP:0001876)2.16591644
62Inflammation of the large intestine (HP:0002037)2.15761021
63Sepsis (HP:0100806)2.13981011
64Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.11186920
65Hypoproteinemia (HP:0003075)2.10620127
66Viral hepatitis (HP:0006562)2.10281730
67Chronic diarrhea (HP:0002028)2.06545203
68Amyotrophic lateral sclerosis (HP:0007354)2.05261403
69Increased muscle lipid content (HP:0009058)2.04445138
70Erythema (HP:0010783)2.04223634
713-Methylglutaconic aciduria (HP:0003535)2.04107561
72Abnormality of DNA repair (HP:0003254)2.03978671
73Recurrent lower respiratory tract infections (HP:0002783)2.02444624
74Joint swelling (HP:0001386)2.00941657
75Mediastinal lymphadenopathy (HP:0100721)1.98961175
76Vasculitis (HP:0002633)1.96739421
77Prominent nose (HP:0000448)1.95312385
78Pulmonary infiltrates (HP:0002113)1.93551563
79Abnormality of the prostate (HP:0008775)1.91406581
80Pustule (HP:0200039)1.88676958
81Oral leukoplakia (HP:0002745)1.88155839
82Recurrent bacterial skin infections (HP:0005406)1.87422853
83Basal ganglia calcification (HP:0002135)1.87181003
84Neutropenia (HP:0001875)1.86555331
85Increased CSF lactate (HP:0002490)1.86554172
86Large eyes (HP:0001090)1.86143861
87Cellulitis (HP:0100658)1.85491185
88Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.85193150
89Ragged-red muscle fibers (HP:0003200)1.83061585
90Prolonged bleeding time (HP:0003010)1.81962402
91Hyperinsulinemic hypoglycemia (HP:0000825)1.81480850
92Chest pain (HP:0100749)1.80911178
93Abnormality of the thymus (HP:0000777)1.79810117
94Keratoconjunctivitis sicca (HP:0001097)1.78965703
95Papilloma (HP:0012740)1.76210826
96Verrucae (HP:0200043)1.76210826
97Increased serum lactate (HP:0002151)1.75028415
98Dicarboxylic aciduria (HP:0003215)1.72975174
99Abnormality of dicarboxylic acid metabolism (HP:0010995)1.72975174
100Abnormality of small intestinal villus morphology (HP:0011472)1.72837342

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KDR5.31730784
2MAP4K13.94932962
3TAOK33.78723838
4TESK23.39652389
5SCYL23.24960183
6BCKDK3.22461439
7VRK23.11772537
8KIT2.91469365
9TXK2.88342657
10TESK12.27855693
11BTK1.97161159
12FES1.87553199
13ITK1.83496804
14CLK11.77905562
15TEC1.77750884
16NUAK11.68031111
17TNK21.67490376
18GRK61.61459182
19CDK121.57835947
20LCK1.54977425
21ZAP701.52227785
22PRKCQ1.50797648
23CDK61.49384099
24SYK1.47739513
25CSF1R1.46760324
26FLT31.45438701
27DAPK11.39456440
28RIPK41.36762603
29TBK11.33700349
30MAPKAPK31.33147132
31LYN1.31795372
32MAP3K111.21686011
33MST41.21221269
34LRRK21.12646465
35HIPK21.10155386
36NME21.04656603
37SMG11.04204779
38IRAK41.02240982
39CDC71.01503839
40CDK91.01047814
41PIK3CG0.99211694
42PRPF4B0.98360202
43NLK0.98309145
44DYRK1B0.97761242
45ERN10.96248507
46HCK0.92726112
47JAK30.90845305
48CSK0.90658051
49MAP3K100.89720941
50PRKCH0.87065040
51CDK40.82776833
52PIM10.82312337
53BMPR20.82120930
54MAP4K20.79099905
55VRK10.76318925
56TYK20.75427162
57ZAK0.75092054
58PASK0.73787168
59IKBKB0.73634681
60RPS6KB20.70107737
61IKBKE0.68879623
62STK100.68436222
63MAP2K60.65810806
64EIF2AK30.64411980
65PIM20.62297449
66CDK190.59965197
67MAP2K30.59198495
68ATR0.57781075
69BRD40.57720155
70UHMK10.53070281
71OXSR10.51144698
72STK390.48236353
73CDK30.48069362
74MAPK110.46944033
75MAP3K140.46304193
76BLK0.44475474
77PDK10.40994479
78MAP3K50.40780652
79STK40.40717077
80FYN0.39782719
81RPS6KA50.39577119
82ABL10.37063958
83CDK80.36147111
84CDK70.34482509
85ADRBK20.31975352
86JAK10.30546384
87MAPK30.29724307
88RPS6KC10.28216135
89RPS6KL10.28216135
90TAF10.28194826
91CHEK20.28032350
92MAPKAPK20.27724008
93CSNK2A20.24917761
94RPS6KA60.24615736
95RPS6KB10.22081392
96CHEK10.22042948
97MARK30.21562420
98MAP2K70.21372109
99MAPK40.20996265
100CSNK2A10.20380404

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053406.04145610
2Allograft rejection_Homo sapiens_hsa053303.03696199
3Autoimmune thyroid disease_Homo sapiens_hsa053202.96838581
4Graft-versus-host disease_Homo sapiens_hsa053322.94953891
5DNA replication_Homo sapiens_hsa030302.68957346
6Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.46133768
7T cell receptor signaling pathway_Homo sapiens_hsa046602.42762107
8Antigen processing and presentation_Homo sapiens_hsa046122.42196753
9Type I diabetes mellitus_Homo sapiens_hsa049402.24664441
10Non-homologous end-joining_Homo sapiens_hsa034502.20087476
11Proteasome_Homo sapiens_hsa030502.19855669
12Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.19775285
13Intestinal immune network for IgA production_Homo sapiens_hsa046722.15634229
14Hematopoietic cell lineage_Homo sapiens_hsa046402.05325053
15Base excision repair_Homo sapiens_hsa034102.04266671
16Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.01503678
17Asthma_Homo sapiens_hsa053102.00675141
18SNARE interactions in vesicular transport_Homo sapiens_hsa041301.97013721
19One carbon pool by folate_Homo sapiens_hsa006701.81062910
20Measles_Homo sapiens_hsa051621.78277775
21Ribosome_Homo sapiens_hsa030101.69765252
22Leishmaniasis_Homo sapiens_hsa051401.68627926
23Homologous recombination_Homo sapiens_hsa034401.59609006
24Viral myocarditis_Homo sapiens_hsa054161.50288612
25RNA polymerase_Homo sapiens_hsa030201.48729584
26Pyrimidine metabolism_Homo sapiens_hsa002401.45698330
27NF-kappa B signaling pathway_Homo sapiens_hsa040641.42016234
28Nucleotide excision repair_Homo sapiens_hsa034201.41777745
29RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.41632713
30Herpes simplex infection_Homo sapiens_hsa051681.37124709
31Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.26225233
32Shigellosis_Homo sapiens_hsa051311.17564106
33B cell receptor signaling pathway_Homo sapiens_hsa046621.17145845
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.13745568
35Spliceosome_Homo sapiens_hsa030401.11535251
36Staphylococcus aureus infection_Homo sapiens_hsa051501.09377647
37Purine metabolism_Homo sapiens_hsa002301.08753176
38Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.07710249
39Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.02229668
40NOD-like receptor signaling pathway_Homo sapiens_hsa046211.00896343
41Other glycan degradation_Homo sapiens_hsa005110.98210182
42Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.97879694
43Parkinsons disease_Homo sapiens_hsa050120.95915393
44Fanconi anemia pathway_Homo sapiens_hsa034600.95819971
45Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.94589853
46Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.92653633
47Mismatch repair_Homo sapiens_hsa034300.84920786
48Peroxisome_Homo sapiens_hsa041460.84199269
49Epstein-Barr virus infection_Homo sapiens_hsa051690.84173053
50Oxidative phosphorylation_Homo sapiens_hsa001900.83667630
51Phototransduction_Homo sapiens_hsa047440.83395864
52Caffeine metabolism_Homo sapiens_hsa002320.83099649
53Jak-STAT signaling pathway_Homo sapiens_hsa046300.82922621
54Acute myeloid leukemia_Homo sapiens_hsa052210.82588705
55Rheumatoid arthritis_Homo sapiens_hsa053230.79801482
56Regulation of autophagy_Homo sapiens_hsa041400.79100298
57Tuberculosis_Homo sapiens_hsa051520.68433076
58RNA degradation_Homo sapiens_hsa030180.67786725
59Salmonella infection_Homo sapiens_hsa051320.66965380
60Malaria_Homo sapiens_hsa051440.66420952
61Influenza A_Homo sapiens_hsa051640.66062431
62Osteoclast differentiation_Homo sapiens_hsa043800.64675044
63Transcriptional misregulation in cancer_Homo sapiens_hsa052020.63610188
64HTLV-I infection_Homo sapiens_hsa051660.63530464
65Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.62090365
66RNA transport_Homo sapiens_hsa030130.61731152
67Hepatitis B_Homo sapiens_hsa051610.59486200
68Non-small cell lung cancer_Homo sapiens_hsa052230.58433906
69Legionellosis_Homo sapiens_hsa051340.57649697
70Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.55499772
71Toll-like receptor signaling pathway_Homo sapiens_hsa046200.54607491
72Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.53970869
73Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.53772475
74Systemic lupus erythematosus_Homo sapiens_hsa053220.53511746
75Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.52007727
76Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.49202410
77Huntingtons disease_Homo sapiens_hsa050160.47595044
78Fatty acid elongation_Homo sapiens_hsa000620.45169598
79Platelet activation_Homo sapiens_hsa046110.45151758
80African trypanosomiasis_Homo sapiens_hsa051430.42325953
81Viral carcinogenesis_Homo sapiens_hsa052030.41861228
82Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.41501616
83Alzheimers disease_Homo sapiens_hsa050100.40502052
84Apoptosis_Homo sapiens_hsa042100.39612629
85Toxoplasmosis_Homo sapiens_hsa051450.37219130
86Leukocyte transendothelial migration_Homo sapiens_hsa046700.35604926
87Chronic myeloid leukemia_Homo sapiens_hsa052200.35212508
88Cell cycle_Homo sapiens_hsa041100.32798440
89Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.31759877
90Propanoate metabolism_Homo sapiens_hsa006400.29910911
91Pertussis_Homo sapiens_hsa051330.29563510
92Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.28732715
93Chemokine signaling pathway_Homo sapiens_hsa040620.25844138
94Butanoate metabolism_Homo sapiens_hsa006500.25341162
95p53 signaling pathway_Homo sapiens_hsa041150.25165994
96Pancreatic cancer_Homo sapiens_hsa052120.24696857
97Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.20227337
98N-Glycan biosynthesis_Homo sapiens_hsa005100.20143175
99Phagosome_Homo sapiens_hsa041450.19705302
100Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.17913637

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