TRBV12-4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular response to interleukin-15 (GO:0071350)6.14170605
2positive regulation of gamma-delta T cell activation (GO:0046645)5.96502868
3pyrimidine nucleoside catabolic process (GO:0046135)5.87991218
4negative regulation by host of viral transcription (GO:0043922)5.70723772
5eosinophil chemotaxis (GO:0048245)5.47184256
6positive regulation of interleukin-8 secretion (GO:2000484)5.26320332
7response to interleukin-15 (GO:0070672)5.20896037
8negative regulation of viral genome replication (GO:0045071)5.01462766
9eosinophil migration (GO:0072677)4.92489584
10regulation of interleukin-12 biosynthetic process (GO:0045075)4.89166145
11positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.84040773
12regulation of lymphocyte chemotaxis (GO:1901623)4.80280355
13positive regulation of B cell differentiation (GO:0045579)4.78312271
14positive regulation of calcium-mediated signaling (GO:0050850)4.78000318
15positive regulation of defense response to virus by host (GO:0002230)4.76545523
16regulation of gamma-delta T cell differentiation (GO:0045586)4.70082514
17T cell migration (GO:0072678)4.67464518
18negative T cell selection (GO:0043383)4.61334965
19negative regulation of T cell apoptotic process (GO:0070233)4.57700407
20positive regulation of interleukin-1 beta secretion (GO:0050718)4.50514838
21production of molecular mediator involved in inflammatory response (GO:0002532)4.48678410
22regulation of regulatory T cell differentiation (GO:0045589)4.47079790
23positive T cell selection (GO:0043368)4.39739647
24DNA demethylation (GO:0080111)4.30906007
25regulation of B cell differentiation (GO:0045577)4.30555573
26lymphocyte chemotaxis (GO:0048247)4.25005575
27positive regulation of interleukin-1 secretion (GO:0050716)4.24867771
28regulation of interleukin-1 beta secretion (GO:0050706)4.23685200
29regulation of gamma-delta T cell activation (GO:0046643)4.21523074
30negative regulation of viral transcription (GO:0032897)4.12854140
31cytolysis (GO:0019835)4.09747543
32macrophage chemotaxis (GO:0048246)4.06804164
33positive regulation of lymphocyte migration (GO:2000403)4.02385739
34positive regulation of natural killer cell mediated immunity (GO:0002717)4.01948225
35positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.81766962
36regulation of interleukin-1 secretion (GO:0050704)3.79910224
37negative regulation of viral process (GO:0048525)3.77972954
38regulation of interleukin-8 secretion (GO:2000482)3.72048772
39regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.71330146
40regulation of natural killer cell mediated immunity (GO:0002715)3.71330146
41positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.64567946
42negative thymic T cell selection (GO:0045060)3.59709714
43positive regulation of interleukin-1 beta production (GO:0032731)3.59236308
44cellular defense response (GO:0006968)3.58545270
45positive thymic T cell selection (GO:0045059)3.57695143
46lymph node development (GO:0048535)3.57320875
47negative regulation of cell killing (GO:0031342)3.56080157
48negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.56080157
49antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.55412518
50positive regulation of tolerance induction (GO:0002645)3.53858972
51regulation of T cell tolerance induction (GO:0002664)3.53129466
52thymic T cell selection (GO:0045061)3.51788713
53regulation of viral genome replication (GO:0045069)3.50410081
54membrane raft organization (GO:0031579)3.50136645
55Arp2/3 complex-mediated actin nucleation (GO:0034314)3.49657244
56T cell selection (GO:0045058)3.48132259
57activated T cell proliferation (GO:0050798)3.46556146
58regulation of calcium-mediated signaling (GO:0050848)3.46218489
59positive regulation of T cell mediated cytotoxicity (GO:0001916)3.39674407
60immunoglobulin mediated immune response (GO:0016064)3.38809425
61pyrimidine-containing compound catabolic process (GO:0072529)3.38095668
62regulation of interleukin-2 biosynthetic process (GO:0045076)3.36238911
63regulation of B cell receptor signaling pathway (GO:0050855)3.34797988
64positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.34707861
65regulation of leukocyte mediated cytotoxicity (GO:0001910)3.32436101
66DNA dealkylation (GO:0035510)3.31214096
67regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.28172347
68negative regulation of lymphocyte apoptotic process (GO:0070229)3.23805041
69positive regulation of cell killing (GO:0031343)3.22532701
70modulation by host of symbiont transcription (GO:0052472)3.21442987
71modulation by host of viral transcription (GO:0043921)3.21442987
72granulocyte activation (GO:0036230)3.20108277
73positive regulation of alpha-beta T cell proliferation (GO:0046641)3.18537862
74positive regulation of interleukin-1 production (GO:0032732)3.17229227
75pyrimidine ribonucleoside metabolic process (GO:0046131)3.16407272
76regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.16028823
77positive regulation of humoral immune response (GO:0002922)3.15276093
78negative regulation of bone mineralization (GO:0030502)3.13641055
79regulation of lymphocyte migration (GO:2000401)3.13403362
80regulation of T cell mediated cytotoxicity (GO:0001914)3.12024055
81regulation of alpha-beta T cell proliferation (GO:0046640)3.11810267
82T cell costimulation (GO:0031295)3.11289718
83lymphocyte costimulation (GO:0031294)3.07225264
84modulation of transcription in other organism involved in symbiotic interaction (GO:0052312)3.05747695
85positive regulation of macrophage differentiation (GO:0045651)3.05692709
86lymphocyte migration (GO:0072676)3.05584062
87response to interferon-beta (GO:0035456)3.04947616
88T cell receptor signaling pathway (GO:0050852)3.02692113
89leukocyte degranulation (GO:0043299)3.01029784
90regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.00776620
91actin nucleation (GO:0045010)2.95862818
92regulation of defense response to virus by host (GO:0050691)2.94785174
93regulation of T cell apoptotic process (GO:0070232)2.93380533
94regulation of T cell receptor signaling pathway (GO:0050856)2.92851097
95cytidine metabolic process (GO:0046087)13.8254336
96cytidine catabolic process (GO:0006216)13.8254336
97cytidine deamination (GO:0009972)13.8254336
98pyrimidine ribonucleoside catabolic process (GO:0046133)12.5158082
99regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:004509110.5263479
100DNA deamination (GO:0045006)10.4736628

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.38071487
2IRF1_21803131_ChIP-Seq_MONOCYTES_Human5.21968162
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.63522452
4IRF8_21731497_ChIP-ChIP_J774_Mouse3.99255592
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.52862820
6STAT4_19710469_ChIP-ChIP_TH1__Mouse3.47400241
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.28674767
8MYB_26560356_Chip-Seq_TH2_Human3.06143904
9ELF1_17652178_ChIP-ChIP_JURKAT_Human2.89492724
10RUNX_20019798_ChIP-Seq_JUKART_Human2.72009852
11STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.64142743
12MYB_26560356_Chip-Seq_TH1_Human2.38980601
13SMAD_19615063_ChIP-ChIP_OVARY_Human2.33439699
14GATA3_27048872_Chip-Seq_THYMUS_Human2.23709461
15RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.20692609
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.19976651
17MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.18140222
18FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.10355971
19SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.06443480
20BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.05159533
21BP1_19119308_ChIP-ChIP_Hs578T_Human12.6507048
22UTX_26944678_Chip-Seq_JUKART_Human1.97802837
23MAF_26560356_Chip-Seq_TH2_Human1.90313296
24MAF_26560356_Chip-Seq_TH1_Human1.84226835
25IRF8_27001747_Chip-Seq_BMDM_Mouse1.82094801
26FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.80176870
27GATA3_26560356_Chip-Seq_TH2_Human1.74413917
28RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.67814433
29CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.62494963
30MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.61074912
31NOTCH1_21737748_ChIP-Seq_TLL_Human1.52289784
32NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.49723653
33GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.48453478
34SPI1_23547873_ChIP-Seq_NB4_Human1.45685670
35LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.42031261
36SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.41893200
37GABP_17652178_ChIP-ChIP_JURKAT_Human1.41854726
38CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.40341477
39TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.37222110
40RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.36540169
41SCL_19346495_ChIP-Seq_HPC-7_Human1.34725089
42SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.33059859
43PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.26899093
44E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.25264954
45STAT6_21828071_ChIP-Seq_BEAS2B_Human1.24226183
46BCL6_27268052_Chip-Seq_Bcells_Human1.13364885
47TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.12776147
48LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.12157407
49HOXB4_20404135_ChIP-ChIP_EML_Mouse1.11351380
50TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.05653662
51GATA1_22025678_ChIP-Seq_K562_Human1.04610475
52GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.04385566
53SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.03692018
54MYB_21317192_ChIP-Seq_ERMYB_Mouse1.02931978
55VDR_23849224_ChIP-Seq_CD4+_Human1.00094705
56GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.98975841
57EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.98771577
58HTT_18923047_ChIP-ChIP_STHdh_Human0.97573964
59EST1_17652178_ChIP-ChIP_JURKAT_Human0.94139055
60FOXP3_21729870_ChIP-Seq_TREG_Human0.93469590
61RUNX1_22412390_ChIP-Seq_EML_Mouse0.90872347
62SPI1_23127762_ChIP-Seq_K562_Human0.89491986
63PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.88982319
64CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.87244136
65CTCF_20526341_ChIP-Seq_ESCs_Human0.84483621
66BRD4_27068464_Chip-Seq_AML-cells_Mouse0.82882917
67NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.81084300
68RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.80767558
69FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79486155
70EGR1_23403033_ChIP-Seq_LIVER_Mouse0.78859768
71CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.78752938
72FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.78187672
73P300_27268052_Chip-Seq_Bcells_Human0.77254487
74SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.75283650
75GATA3_26560356_Chip-Seq_TH1_Human0.73248005
76FOXA1_27270436_Chip-Seq_PROSTATE_Human0.72370475
77FOXA1_25329375_ChIP-Seq_VCAP_Human0.72370475
78RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.71783209
79FLI1_27457419_Chip-Seq_LIVER_Mouse0.71647808
80VDR_22108803_ChIP-Seq_LS180_Human0.70690221
81BCOR_27268052_Chip-Seq_Bcells_Human0.70595742
82JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.70292516
83SA1_27219007_Chip-Seq_Bcells_Human0.66642273
84ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.65741123
85YY1_22570637_ChIP-Seq_MALME-3M_Human0.65393317
86ELF1_20517297_ChIP-Seq_JURKAT_Human0.65243663
87FOXA1_21572438_ChIP-Seq_LNCaP_Human0.64791616
88CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.64658966
89VDR_24763502_ChIP-Seq_THP-1_Human0.62260204
90EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.61785240
91NANOG_20526341_ChIP-Seq_ESCs_Human0.61745934
92TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.61586451
93VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.61058506
94FOXH1_21741376_ChIP-Seq_EPCs_Human0.60551356
95PU.1_20513432_ChIP-Seq_Bcells_Mouse0.59713309
96CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.59641621
97CIITA_25753668_ChIP-Seq_RAJI_Human0.59525753
98STAT1_20625510_ChIP-Seq_HELA_Human0.57629697
99CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.56865779
100VDR_24787735_ChIP-Seq_THP-1_Human0.56436126

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to5.50657879
2MP0009333_abnormal_splenocyte_physiolog4.95472658
3MP0003763_abnormal_thymus_physiology4.56356705
4MP0006082_CNS_inflammation4.18587425
5MP0009785_altered_susceptibility_to4.04245536
6MP0005000_abnormal_immune_tolerance3.31482125
7MP0001835_abnormal_antigen_presentation3.18751681
8MP0001800_abnormal_humoral_immune3.13627894
9MP0003436_decreased_susceptibility_to3.10393949
10MP0002148_abnormal_hypersensitivity_rea2.97528882
11MP0002420_abnormal_adaptive_immunity2.95624817
12MP0005387_immune_system_phenotype2.87608947
13MP0001790_abnormal_immune_system2.87608947
14MP0001819_abnormal_immune_cell2.85041602
15MP0005025_abnormal_response_to2.84305180
16MP0002723_abnormal_immune_serum2.82361207
17MP0003448_altered_tumor_morphology2.50532726
18MP0000569_abnormal_digit_pigmentation2.37121135
19MP0002452_abnormal_antigen_presenting2.33195869
20MP0002419_abnormal_innate_immunity2.31257827
21MP0002398_abnormal_bone_marrow2.28713368
22MP0003866_abnormal_defecation2.27824773
23MP0000716_abnormal_immune_system2.27524886
24MP0000703_abnormal_thymus_morphology2.25469409
25MP0002166_altered_tumor_susceptibility2.13186446
26MP0010155_abnormal_intestine_physiology2.09181357
27MP0000685_abnormal_immune_system1.91763981
28MP0002722_abnormal_immune_system1.88632499
29MP0003045_fibrosis1.84734558
30MP0001845_abnormal_inflammatory_respons1.82297642
31MP0000689_abnormal_spleen_morphology1.81319948
32MP0002429_abnormal_blood_cell1.79821077
33MP0002405_respiratory_system_inflammati1.71604496
34MP0004947_skin_inflammation1.67057619
35MP0002006_tumorigenesis1.60835421
36MP0009763_increased_sensitivity_to1.60631471
37MP0003279_aneurysm1.60323605
38MP0009765_abnormal_xenobiotic_induced1.49940299
39MP0001958_emphysema1.49899209
40MP0002877_abnormal_melanocyte_morpholog1.49708818
41MP0002138_abnormal_hepatobiliary_system1.40796913
42MP0008469_abnormal_protein_level1.40690489
43MP0003724_increased_susceptibility_to1.40516947
44MP0000858_altered_metastatic_potential1.36847002
45MP0001533_abnormal_skeleton_physiology1.35334328
46MP0002277_abnormal_respiratory_mucosa1.32193386
47MP0005464_abnormal_platelet_physiology1.26953715
48MP0003075_altered_response_to1.18187930
49MP0001873_stomach_inflammation1.16847613
50MP0003786_premature_aging1.14245362
51MP0001501_abnormal_sleep_pattern1.10619371
52MP0002163_abnormal_gland_morphology1.08232466
53MP0005310_abnormal_salivary_gland1.03376020
54MP0002876_abnormal_thyroid_physiology1.01475651
55MP0002998_abnormal_bone_remodeling1.00889183
56MP0002933_joint_inflammation0.99408609
57MP0008873_increased_physiological_sensi0.98903618
58MP0009764_decreased_sensitivity_to0.94874427
59MP0002132_abnormal_respiratory_system0.93925592
60MP0000604_amyloidosis0.91392357
61MP0003183_abnormal_peptide_metabolism0.90678991
62MP0006054_spinal_hemorrhage0.89286232
63MP0001919_abnormal_reproductive_system0.89279358
64MP0001853_heart_inflammation0.88422834
65MP0004145_abnormal_muscle_electrophysio0.87246731
66MP0002019_abnormal_tumor_incidence0.85922224
67MP0005584_abnormal_enzyme/coenzyme_acti0.85679115
68MP0000639_abnormal_adrenal_gland0.82851265
69MP0005165_increased_susceptibility_to0.81327515
70MP0005408_hypopigmentation0.76996826
71MP0004381_abnormal_hair_follicle0.75300231
72MP0005623_abnormal_meninges_morphology0.74329404
73MP0008260_abnormal_autophagy0.70466503
74MP0005390_skeleton_phenotype0.69743394
75MP0004510_myositis0.66259398
76MP0001348_abnormal_lacrimal_gland0.65855053
77MP0002693_abnormal_pancreas_physiology0.64998905
78MP0003300_gastrointestinal_ulcer0.64413302
79MP0005257_abnormal_intraocular_pressure0.62136392
80MP0005075_abnormal_melanosome_morpholog0.58376834
81MP0002136_abnormal_kidney_physiology0.55324716
82MP0002102_abnormal_ear_morphology0.54842377
83MP0003795_abnormal_bone_structure0.53833527
84MP0001188_hyperpigmentation0.52293758
85MP0008872_abnormal_physiological_respon0.52141826
86MP0000920_abnormal_myelination0.48939664
87MP0001502_abnormal_circadian_rhythm0.48835574
88MP0004742_abnormal_vestibular_system0.48806247
89MP0000681_abnormal_thyroid_gland0.46607232
90MP0002168_other_aberrant_phenotype0.46199449
91MP0005410_abnormal_fertilization0.44691303
92MP0005166_decreased_susceptibility_to0.42760943
93MP0005174_abnormal_tail_pigmentation0.42344082
94MP0001243_abnormal_dermal_layer0.39659279
95MP0003172_abnormal_lysosome_physiology0.39646758
96MP0002095_abnormal_skin_pigmentation0.39490596
97MP0000477_abnormal_intestine_morphology0.38562335
98MP0002083_premature_death0.37436578
99MP0001986_abnormal_taste_sensitivity0.37186535
100MP0008569_lethality_at_weaning0.34781142

Predicted human phenotypes

RankGene SetZ-score
1Aplastic anemia (HP:0001915)9.42345304
2T lymphocytopenia (HP:0005403)8.96969473
3Abnormality of T cell number (HP:0011839)8.83402312
4Autoimmune hemolytic anemia (HP:0001890)6.44978185
5Abnormality of T cells (HP:0002843)6.02209786
6Autoimmune thrombocytopenia (HP:0001973)5.10132430
7Increased IgM level (HP:0003496)4.76709981
8Abnormal delayed hypersensitivity skin test (HP:0002963)4.75223090
9Abnormality of macrophages (HP:0004311)4.55331622
10Chronic diarrhea (HP:0002028)4.51573220
11IgG deficiency (HP:0004315)4.43934573
12Abnormality of eosinophils (HP:0001879)4.43426689
13Severe combined immunodeficiency (HP:0004430)4.42206470
14Recurrent viral infections (HP:0004429)4.39199129
15Eosinophilia (HP:0001880)4.38802734
16Granulocytopenia (HP:0001913)4.26935031
17Stomatitis (HP:0010280)3.89521932
18Joint swelling (HP:0001386)3.88237193
19Recurrent fungal infections (HP:0002841)3.77844942
20Abnormality of T cell physiology (HP:0011840)3.77452644
21Recurrent cutaneous fungal infections (HP:0011370)3.75705891
22Chronic mucocutaneous candidiasis (HP:0002728)3.75705891
23IgA deficiency (HP:0002720)3.73668571
24Combined immunodeficiency (HP:0005387)3.70206665
25Leukocytosis (HP:0001974)3.47181284
26IgM deficiency (HP:0002850)3.40081677
27Recurrent bronchitis (HP:0002837)3.35308183
28Abnormality of B cell number (HP:0010975)3.27517237
29Oral leukoplakia (HP:0002745)3.16199770
30Myositis (HP:0100614)3.14432901
31Thyroiditis (HP:0100646)3.13386006
32Menstrual irregularities (HP:0000858)3.08848812
33Pustule (HP:0200039)3.07116496
34Abnormality of cells of the lymphoid lineage (HP:0012140)3.06835717
35Elevated erythrocyte sedimentation rate (HP:0003565)3.05748593
36Lymphopenia (HP:0001888)2.86562945
37Lymphoma (HP:0002665)2.80328199
38Glucose intolerance (HP:0000833)2.67905038
39Oligomenorrhea (HP:0000876)2.60968662
40Renal cortical cysts (HP:0000803)2.58249101
41Hypergammaglobulinemia (HP:0010702)2.58093858
42Encephalitis (HP:0002383)2.53698317
43Vasculitis (HP:0002633)2.49638700
44Orchitis (HP:0100796)2.49206592
45Meningitis (HP:0001287)2.49101846
46Optic neuritis (HP:0100653)2.49023575
47Retrobulbar optic neuritis (HP:0100654)2.49023575
48Pancytopenia (HP:0001876)2.48906803
49Carpal bone hypoplasia (HP:0001498)2.46623902
50Recurrent skin infections (HP:0001581)2.42799710
51Abnormality of oral frenula (HP:0000190)2.38591381
52Pulmonary infiltrates (HP:0002113)2.35490510
53Increased neuronal autofluorescent lipopigment (HP:0002074)2.35464812
54Periodontitis (HP:0000704)2.34217348
55Hypoplasia of the thymus (HP:0000778)2.27673889
56Hypoproteinemia (HP:0003075)2.25979141
57Abnormality of liposaccharide metabolism (HP:0010968)2.21960095
58Abnormality of glycosphingolipid metabolism (HP:0004343)2.21960095
59Abnormality of glycolipid metabolism (HP:0010969)2.21960095
60Recurrent bacterial skin infections (HP:0005406)2.21190885
61B lymphocytopenia (HP:0010976)2.16997673
62Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.13784251
63Increased cerebral lipofuscin (HP:0011813)2.13581081
64Aplasia/hypoplasia of the uterus (HP:0008684)2.12530886
65Decreased electroretinogram (ERG) amplitude (HP:0000654)2.11856159
66Recurrent abscess formation (HP:0002722)2.10551157
67Agammaglobulinemia (HP:0004432)2.03573761
68Obstructive lung disease (HP:0006536)2.02672486
69Chronic obstructive pulmonary disease (HP:0006510)2.02672486
70Hypochromic anemia (HP:0001931)2.02249697
71Hepatosplenomegaly (HP:0001433)2.02012937
72Striae distensae (HP:0001065)1.98466328
73Bronchitis (HP:0012387)1.98158636
74Premature loss of primary teeth (HP:0006323)1.94338424
75Abnormality of the alveolar ridges (HP:0006477)1.92892276
76Hemiplegia (HP:0002301)1.90984157
77Hemoptysis (HP:0002105)1.90955894
78Mediastinal lymphadenopathy (HP:0100721)1.88269904
79Vacuolated lymphocytes (HP:0001922)1.82670048
80Purpura (HP:0000979)1.81941109
81Stomach cancer (HP:0012126)1.81063966
823-Methylglutaconic aciduria (HP:0003535)1.80728794
83Metaphyseal dysplasia (HP:0100255)1.80582662
84Abnormality of the prostate (HP:0008775)1.79968129
85Acute hepatic failure (HP:0006554)1.79887760
86Abnormality of the renal cortex (HP:0011035)1.78432516
87Vertebral compression fractures (HP:0002953)1.77126797
88Hypoplasia of the uterus (HP:0000013)1.75262433
89Hypoalbuminemia (HP:0003073)1.72160806
90Abnormal albumin level (HP:0012116)1.72160806
91Anorexia (HP:0002039)1.70552556
92Nasolacrimal duct obstruction (HP:0000579)1.70360882
93Erythema (HP:0010783)1.69623460
94Gastrointestinal infarctions (HP:0005244)1.65137396
95Eczematoid dermatitis (HP:0000976)1.65077397
96Abnormal glucose tolerance (HP:0001952)1.64460609
97Pulmonary fibrosis (HP:0002206)1.60642877
98Keratoconjunctivitis sicca (HP:0001097)1.59558547
99Progressive inability to walk (HP:0002505)1.58506222
100Alkalosis (HP:0001948)1.58370603

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PIK3CA5.72045116
2TXK5.55845989
3KDR4.14990679
4ITK4.09054277
5MAP4K13.99600339
6TESK22.99810681
7FES2.68685372
8EIF2AK32.67061135
9TAOK32.65434587
10BCKDK2.33173060
11CSK2.19466688
12JAK32.08020382
13BUB11.96567229
14TYK21.85966158
15IKBKE1.85066141
16TYRO31.65128127
17PRKCQ1.63801802
18RIPK41.54697640
19NUAK11.52248745
20SYK1.48282092
21TNK21.47825687
22BTK1.47250406
23LCK1.46557083
24ACVR1B1.45484025
25PASK1.45345142
26TESK11.40501621
27MAPKAPK31.39807507
28LYN1.38627601
29FGFR41.33899683
30KIT1.29387017
31PINK11.23945759
32BLK1.20833729
33EIF2AK11.12770750
34ZAP701.11878015
35IKBKB1.09977683
36PRKD31.08214032
37MAP2K71.06416016
38VRK21.02760069
39TBK11.02569359
40TEC0.96782541
41MAP3K110.92586252
42ADRBK20.91285436
43CAMKK10.90623892
44MAPK110.90254449
45IRAK40.88098794
46HCK0.84882005
47STK380.83956514
48MST40.83729160
49CAMKK20.81216657
50AKT30.80691623
51MAP3K140.80486623
52RET0.79556806
53FYN0.79379473
54JAK10.79297974
55ERN10.78207312
56PIK3CG0.78020292
57GRK60.69439774
58FGFR10.62694920
59BMPR20.62687512
60DAPK20.58991697
61FGFR30.53948954
62MARK30.50677766
63DAPK10.50167024
64PRKCD0.48982148
65NEK60.48614532
66MAP2K60.45765898
67MAPK120.45014065
68CSF1R0.43870941
69RIPK10.43603221
70MAP3K120.43336462
71IGF1R0.42788267
72TAOK20.42699366
73GRK10.40305555
74MAP4K20.38178072
75LIMK10.37498830
76MAP3K70.34383124
77PAK10.33627046
78STK100.32939476
79SRC0.32800396
80SIK30.32306898
81CAMK2D0.30878797
82SRPK10.30787987
83BCR0.29346325
84INSR0.29253492
85MAPKAPK20.29184243
86MAP3K30.28744030
87EGFR0.28600837
88ROCK10.27866619
89PRKCA0.25930905
90PRKCB0.24647267
91PRKCH0.24155201
92PDK10.23670401
93JAK20.23218800
94CAMK2A0.22556459
95ILK0.20966513
96CHUK0.20520819
97MAP3K10.19322946
98PRKD20.19156127
99VRK10.19140500
100TAOK10.17578605

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053325.18010568
2Primary immunodeficiency_Homo sapiens_hsa053405.10519745
3Antigen processing and presentation_Homo sapiens_hsa046124.34837204
4Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046504.11356088
5Allograft rejection_Homo sapiens_hsa053303.74766556
6Autoimmune thyroid disease_Homo sapiens_hsa053203.51657039
7Proteasome_Homo sapiens_hsa030503.12683447
8Cytosolic DNA-sensing pathway_Homo sapiens_hsa046233.07776434
9Type I diabetes mellitus_Homo sapiens_hsa049402.89193571
10Hematopoietic cell lineage_Homo sapiens_hsa046402.85085554
11NF-kappa B signaling pathway_Homo sapiens_hsa040642.61076710
12T cell receptor signaling pathway_Homo sapiens_hsa046602.57935818
13Rheumatoid arthritis_Homo sapiens_hsa053232.26540148
14Toll-like receptor signaling pathway_Homo sapiens_hsa046202.21460027
15Measles_Homo sapiens_hsa051622.08980418
16Cytokine-cytokine receptor interaction_Homo sapiens_hsa040602.06720389
17Salmonella infection_Homo sapiens_hsa051321.90312476
18Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.71134022
19Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.69024724
20RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.58397706
21Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.38286468
22NOD-like receptor signaling pathway_Homo sapiens_hsa046211.37710696
23Viral myocarditis_Homo sapiens_hsa054161.35174647
24Chemokine signaling pathway_Homo sapiens_hsa040621.17920324
25Osteoclast differentiation_Homo sapiens_hsa043801.15426504
26Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.07559360
27Apoptosis_Homo sapiens_hsa042101.07443152
28Shigellosis_Homo sapiens_hsa051311.01625601
29Intestinal immune network for IgA production_Homo sapiens_hsa046721.00766311
30Protein export_Homo sapiens_hsa030600.96230291
31Fatty acid elongation_Homo sapiens_hsa000620.95829575
32Herpes simplex infection_Homo sapiens_hsa051680.95266001
33Jak-STAT signaling pathway_Homo sapiens_hsa046300.94789285
34RNA polymerase_Homo sapiens_hsa030200.85747614
35TNF signaling pathway_Homo sapiens_hsa046680.85299509
36Leishmaniasis_Homo sapiens_hsa051400.80540912
37Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.79068875
38African trypanosomiasis_Homo sapiens_hsa051430.76453678
39Legionellosis_Homo sapiens_hsa051340.76216637
40Caffeine metabolism_Homo sapiens_hsa002320.74347533
41Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.74152593
42Epstein-Barr virus infection_Homo sapiens_hsa051690.71631067
43SNARE interactions in vesicular transport_Homo sapiens_hsa041300.69935155
44Oxidative phosphorylation_Homo sapiens_hsa001900.67814787
45Asthma_Homo sapiens_hsa053100.67577543
46Malaria_Homo sapiens_hsa051440.66343088
47Influenza A_Homo sapiens_hsa051640.64660079
48Staphylococcus aureus infection_Homo sapiens_hsa051500.63729962
49Regulation of autophagy_Homo sapiens_hsa041400.62743280
50Galactose metabolism_Homo sapiens_hsa000520.60785552
51Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.59267146
52Sulfur metabolism_Homo sapiens_hsa009200.56187905
53Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.54718203
54Pertussis_Homo sapiens_hsa051330.54440096
55Parkinsons disease_Homo sapiens_hsa050120.54262618
56Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.52276750
57Tuberculosis_Homo sapiens_hsa051520.49857547
58Lysosome_Homo sapiens_hsa041420.49482543
59Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.46379726
60Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.44847596
61Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.41125738
62Nitrogen metabolism_Homo sapiens_hsa009100.40549728
63Linoleic acid metabolism_Homo sapiens_hsa005910.37564421
64Prion diseases_Homo sapiens_hsa050200.37201395
65N-Glycan biosynthesis_Homo sapiens_hsa005100.35462224
66Systemic lupus erythematosus_Homo sapiens_hsa053220.34731799
67Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.32835562
68Alzheimers disease_Homo sapiens_hsa050100.32681769
69HTLV-I infection_Homo sapiens_hsa051660.31693856
70B cell receptor signaling pathway_Homo sapiens_hsa046620.31274845
71alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.31207915
72Hepatitis B_Homo sapiens_hsa051610.30418747
73Toxoplasmosis_Homo sapiens_hsa051450.29847941
74Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.24619249
75Transcriptional misregulation in cancer_Homo sapiens_hsa052020.22674317
76Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.21609617
77Endocytosis_Homo sapiens_hsa041440.21009764
78Circadian rhythm_Homo sapiens_hsa047100.19473387
79Peroxisome_Homo sapiens_hsa041460.16649588
80Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.13162121
81Phagosome_Homo sapiens_hsa041450.10675711
82VEGF signaling pathway_Homo sapiens_hsa043700.09030259
83Drug metabolism - other enzymes_Homo sapiens_hsa009830.08790875
84Leukocyte transendothelial migration_Homo sapiens_hsa046700.06115580
85Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.06051447
86Pyrimidine metabolism_Homo sapiens_hsa002400.05585012
87Hepatitis C_Homo sapiens_hsa051600.05199475
88Viral carcinogenesis_Homo sapiens_hsa052030.04154608
89Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.03681060
90Collecting duct acid secretion_Homo sapiens_hsa049660.02812059
91Regulation of actin cytoskeleton_Homo sapiens_hsa048100.01810087
92Mineral absorption_Homo sapiens_hsa049780.00499990
93Platelet activation_Homo sapiens_hsa04611-0.0541069
94Phototransduction_Homo sapiens_hsa04744-0.0450980
95Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.0416367
96Fc epsilon RI signaling pathway_Homo sapiens_hsa04664-0.0395671
97Huntingtons disease_Homo sapiens_hsa05016-0.0164158
98MAPK signaling pathway_Homo sapiens_hsa04010-0.0151497
99Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603-0.0148962
100Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524-0.0082365

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »