TRBV12-5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytidine metabolic process (GO:0046087)8.98075827
2cytidine catabolic process (GO:0006216)8.98075827
3cytidine deamination (GO:0009972)8.98075827
4pyrimidine ribonucleoside catabolic process (GO:0046133)8.14408503
5DNA deamination (GO:0045006)7.00617597
6regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450916.20016129
7negative regulation of cAMP-mediated signaling (GO:0043951)5.85803411
8positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.63005202
9positive regulation of gamma-delta T cell activation (GO:0046645)5.62021601
10negative T cell selection (GO:0043383)5.40521055
11cellular response to interleukin-15 (GO:0071350)5.38884101
12negative regulation of cytosolic calcium ion concentration (GO:0051481)5.36580275
13antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.03608061
14opioid receptor signaling pathway (GO:0038003)4.89297149
15response to interleukin-15 (GO:0070672)4.78943809
16negative thymic T cell selection (GO:0045060)4.74094271
17regulation of gamma-delta T cell differentiation (GO:0045586)4.51074907
18negative regulation of calcium ion-dependent exocytosis (GO:0045955)4.49989594
19negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.48793505
20negative regulation of cell killing (GO:0031342)4.48793505
21regulation of interleukin-12 biosynthetic process (GO:0045075)4.44594444
22T cell migration (GO:0072678)4.41044408
23regulation of regulatory T cell differentiation (GO:0045589)4.30697679
24positive T cell selection (GO:0043368)4.28987411
25regulation of B cell receptor signaling pathway (GO:0050855)4.27134533
26regulation of T cell tolerance induction (GO:0002664)4.23254975
27regulation of gamma-delta T cell activation (GO:0046643)4.17578056
28positive regulation of B cell differentiation (GO:0045579)4.17140897
29pyrimidine nucleoside catabolic process (GO:0046135)4.10491811
30thymic T cell selection (GO:0045061)4.09705545
31signal complex assembly (GO:0007172)4.06065536
32positive regulation of tolerance induction (GO:0002645)4.04351140
33regulation of B cell differentiation (GO:0045577)4.03290535
34positive regulation of T cell mediated cytotoxicity (GO:0001916)4.01282319
35negative regulation of nitric oxide biosynthetic process (GO:0045019)4.00436868
36negative regulation of glycoprotein biosynthetic process (GO:0010561)3.99014494
37T cell selection (GO:0045058)3.94261749
38regulation of acrosome reaction (GO:0060046)3.90786105
39antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.89694498
40positive thymic T cell selection (GO:0045059)3.88600631
41adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.86101756
42negative regulation by host of viral transcription (GO:0043922)3.80705859
43mast cell activation (GO:0045576)3.75853437
44positive regulation of defense response to virus by host (GO:0002230)3.75627123
45positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.73913104
46regulation of translational termination (GO:0006449)3.68750075
47positive regulation of calcium-mediated signaling (GO:0050850)3.68642941
48positive regulation of interleukin-1 beta secretion (GO:0050718)3.66126248
49regulation of interleukin-1 beta secretion (GO:0050706)3.66052433
50regulation of T cell mediated cytotoxicity (GO:0001914)3.64690542
51thrombin receptor signaling pathway (GO:0070493)3.57870329
52regulation of tolerance induction (GO:0002643)3.57289751
53positive regulation of interleukin-8 secretion (GO:2000484)3.55746597
54antigen processing and presentation of endogenous antigen (GO:0019883)3.53533330
55negative regulation of calcium ion transport into cytosol (GO:0010523)3.51642550
56positive regulation of cAMP-mediated signaling (GO:0043950)3.50009195
57adult feeding behavior (GO:0008343)3.45426736
58positive regulation of interleukin-1 secretion (GO:0050716)3.44767849
59ether lipid metabolic process (GO:0046485)3.43967916
60negative regulation of T cell apoptotic process (GO:0070233)3.43755288
61positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.43536143
62activated T cell proliferation (GO:0050798)3.41213352
63negative regulation of viral genome replication (GO:0045071)3.40850062
64leukocyte aggregation (GO:0070486)3.40030917
65antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.39831573
66regulation of alpha-beta T cell proliferation (GO:0046640)3.39227051
67tolerance induction (GO:0002507)3.37650220
68positive regulation of humoral immune response (GO:0002922)3.33356628
69behavioral response to ethanol (GO:0048149)3.25788109
70lymphocyte chemotaxis (GO:0048247)3.25224450
71production of molecular mediator involved in inflammatory response (GO:0002532)3.24170722
72regulation of lymphocyte chemotaxis (GO:1901623)3.23975106
73regulation of interleukin-1 secretion (GO:0050704)3.21602208
74T cell receptor signaling pathway (GO:0050852)3.19153431
75regulation of interleukin-2 biosynthetic process (GO:0045076)3.17929863
76regulation of leukocyte mediated cytotoxicity (GO:0001910)3.14306747
77regulation of isotype switching to IgG isotypes (GO:0048302)3.12587663
78regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.12255605
79piRNA metabolic process (GO:0034587)3.09651493
80positive regulation of alpha-beta T cell proliferation (GO:0046641)3.07551506
81negative regulation of lymphocyte mediated immunity (GO:0002707)3.07514132
82regulation of natural killer cell mediated immunity (GO:0002715)3.06724013
83regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.06724013
84lymph node development (GO:0048535)3.04833197
85regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.02831704
86positive regulation of cell killing (GO:0031343)3.01140053
87regulation of memory T cell differentiation (GO:0043380)3.00798955
88regulation of interleukin-8 secretion (GO:2000482)2.99221145
89positive regulation of interleukin-1 beta production (GO:0032731)2.97731462
90negative regulation of T cell mediated immunity (GO:0002710)2.97613742
91regulation of defense response to virus by host (GO:0050691)2.96519701
92eosinophil chemotaxis (GO:0048245)2.96107442
93antigen receptor-mediated signaling pathway (GO:0050851)2.92604131
94cellular defense response (GO:0006968)2.91099148
95immunoglobulin mediated immune response (GO:0016064)2.88728475
96negative regulation of viral transcription (GO:0032897)2.88610699
97T cell costimulation (GO:0031295)2.87561518
98lymphocyte migration (GO:0072676)2.87040307
99positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.85059948
100lymphocyte costimulation (GO:0031294)2.83693640

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human8.73332094
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.97353959
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.49676951
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.28376668
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.76008986
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.55953813
7RUNX_20019798_ChIP-Seq_JUKART_Human3.51595277
8IRF8_22096565_ChIP-ChIP_GC-B_Human3.04012777
9MYB_26560356_Chip-Seq_TH2_Human2.86296578
10STAT4_19710469_ChIP-ChIP_TH1__Mouse2.57672919
11STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.51083828
12FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.50885656
13GATA3_27048872_Chip-Seq_THYMUS_Human2.42844048
14MYB_26560356_Chip-Seq_TH1_Human2.41707215
15MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.34714082
16SCL_19346495_ChIP-Seq_HPC-7_Human2.32247194
17FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.25146376
18IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.17520669
19RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.17414626
20SMAD_19615063_ChIP-ChIP_OVARY_Human2.08016929
21VDR_22108803_ChIP-Seq_LS180_Human2.00135519
22E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.86338547
23UTX_26944678_Chip-Seq_JUKART_Human1.85793823
24IRF8_27001747_Chip-Seq_BMDM_Mouse1.81308363
25ELF1_17652178_ChIP-ChIP_JURKAT_Human1.79632250
26SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.73690147
27GATA3_26560356_Chip-Seq_TH2_Human1.73420270
28SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.71326921
29MAF_26560356_Chip-Seq_TH2_Human1.62661012
30MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.60491361
31MAF_26560356_Chip-Seq_TH1_Human1.59934239
32NOTCH1_21737748_ChIP-Seq_TLL_Human1.56149694
33SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.54822645
34RXR_22108803_ChIP-Seq_LS180_Human1.50659924
35SPI1_23547873_ChIP-Seq_NB4_Human1.46042912
36FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.44442316
37LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.37163194
38GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.33020917
39VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.28457663
40SPI1_23127762_ChIP-Seq_K562_Human1.25633785
41VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.24401996
42TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.24164555
43ZNF274_21170338_ChIP-Seq_K562_Hela1.21261092
44HTT_18923047_ChIP-ChIP_STHdh_Human1.19761893
45EGR1_23403033_ChIP-Seq_LIVER_Mouse1.17909255
46RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16867820
47EGR1_19032775_ChIP-ChIP_M12_Human1.16120984
48PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.15738938
49FLI1_27457419_Chip-Seq_LIVER_Mouse1.14813200
50NANOG_20526341_ChIP-Seq_ESCs_Human1.14726408
51RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.14386632
52TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.13594922
53RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.10375209
54RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.09786548
55IRF1_19129219_ChIP-ChIP_H3396_Human1.08317200
56VDR_24763502_ChIP-Seq_THP-1_Human1.08282457
57GATA3_26560356_Chip-Seq_TH1_Human1.07097456
58LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.04091198
59SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.04052708
60PRDM14_20953172_ChIP-Seq_ESCs_Human1.03742345
61VDR_24787735_ChIP-Seq_THP-1_Human1.02735321
62BCL6_27268052_Chip-Seq_Bcells_Human1.02679647
63SMRT_27268052_Chip-Seq_Bcells_Human1.00617176
64EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.97871937
65AR_21572438_ChIP-Seq_LNCaP_Human0.95087251
66GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.94799651
67RUNX1_22412390_ChIP-Seq_EML_Mouse0.94125683
68PCGF2_27294783_Chip-Seq_ESCs_Mouse0.90864404
69BRD4_27068464_Chip-Seq_AML-cells_Mouse0.90332933
70MYB_21317192_ChIP-Seq_ERMYB_Mouse0.90299221
71GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.90055348
72BCAT_22108803_ChIP-Seq_LS180_Human0.90009850
73HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.89455537
74PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.88601707
75RAC3_21632823_ChIP-Seq_H3396_Human0.87923396
76BCOR_27268052_Chip-Seq_Bcells_Human0.87574418
77EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.86454088
78TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.86286233
79PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.86013508
80RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.85408435
81FOXH1_21741376_ChIP-Seq_ESCs_Human0.83446724
82MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.83238136
83GBX2_23144817_ChIP-Seq_PC3_Human0.83030348
84CTCF_20526341_ChIP-Seq_ESCs_Human0.82151928
85NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.81637642
86FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80468190
87PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.78302091
88CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.75582703
89GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.75436911
90CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.75055103
91TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.75003304
92TAF15_26573619_Chip-Seq_HEK293_Human0.74729861
93PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.74234857
94ELF1_20517297_ChIP-Seq_JURKAT_Human0.73683337
95E2F1_20622854_ChIP-Seq_HELA_Human0.73623193
96CEBPB_22108803_ChIP-Seq_LS180_Human0.73312938
97GATA3_21878914_ChIP-Seq_MCF-7_Human0.73070807
98POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.72189881
99TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.72189881
100P300_27268052_Chip-Seq_Bcells_Human0.71864020

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009333_abnormal_splenocyte_physiolog4.95668804
2MP0005671_abnormal_response_to4.67371992
3MP0003763_abnormal_thymus_physiology4.10518614
4MP0003436_decreased_susceptibility_to3.24265839
5MP0009785_altered_susceptibility_to3.01835118
6MP0006082_CNS_inflammation2.96763302
7MP0001800_abnormal_humoral_immune2.95768182
8MP0005000_abnormal_immune_tolerance2.93352014
9MP0009278_abnormal_bone_marrow2.87523734
10MP0002876_abnormal_thyroid_physiology2.80928038
11MP0002148_abnormal_hypersensitivity_rea2.76537085
12MP0002420_abnormal_adaptive_immunity2.70187958
13MP0001819_abnormal_immune_cell2.61863181
14MP0001835_abnormal_antigen_presentation2.59829160
15MP0005387_immune_system_phenotype2.59827156
16MP0001790_abnormal_immune_system2.59827156
17MP0002723_abnormal_immune_serum2.51588330
18MP0005025_abnormal_response_to2.39570541
19MP0003866_abnormal_defecation2.35135209
20MP0000685_abnormal_immune_system2.33039713
21MP0002452_abnormal_antigen_presenting2.23064572
22MP0003183_abnormal_peptide_metabolism2.21102461
23MP0000703_abnormal_thymus_morphology2.20066755
24MP0002419_abnormal_innate_immunity2.19957311
25MP0003045_fibrosis2.14830977
26MP0002398_abnormal_bone_marrow2.08928512
27MP0000716_abnormal_immune_system2.08867787
28MP0010155_abnormal_intestine_physiology1.99160508
29MP0009764_decreased_sensitivity_to1.97293266
30MP0000678_abnormal_parathyroid_gland1.96187408
31MP0002405_respiratory_system_inflammati1.84886290
32MP0005360_urolithiasis1.72822235
33MP0001501_abnormal_sleep_pattern1.72811807
34MP0001968_abnormal_touch/_nociception1.71862335
35MP0002722_abnormal_immune_system1.71452236
36MP0003724_increased_susceptibility_to1.70632469
37MP0005310_abnormal_salivary_gland1.66991679
38MP0000689_abnormal_spleen_morphology1.63855286
39MP0009765_abnormal_xenobiotic_induced1.59859231
40MP0001845_abnormal_inflammatory_respons1.58279601
41MP0002429_abnormal_blood_cell1.56954899
42MP0001533_abnormal_skeleton_physiology1.46802598
43MP0000681_abnormal_thyroid_gland1.44773015
44MP0004947_skin_inflammation1.43918700
45MP0001873_stomach_inflammation1.43801628
46MP0002277_abnormal_respiratory_mucosa1.38146458
47MP0006035_abnormal_mitochondrial_morpho1.36947532
48MP0005257_abnormal_intraocular_pressure1.32510943
49MP0008872_abnormal_physiological_respon1.20559090
50MP0003191_abnormal_cellular_cholesterol1.20315977
51MP0008469_abnormal_protein_level1.17971187
52MP0005464_abnormal_platelet_physiology1.17890454
53MP0003448_altered_tumor_morphology1.16996986
54MP0002998_abnormal_bone_remodeling1.13137957
55MP0002693_abnormal_pancreas_physiology1.12272880
56MP0005503_abnormal_tendon_morphology1.08284705
57MP0001664_abnormal_digestion1.06725931
58MP0009780_abnormal_chondrocyte_physiolo1.03731073
59MP0004381_abnormal_hair_follicle1.01808382
60MP0001851_eye_inflammation0.99375010
61MP0006054_spinal_hemorrhage0.98943853
62MP0001919_abnormal_reproductive_system0.96926233
63MP0001853_heart_inflammation0.93775928
64MP0001545_abnormal_hematopoietic_system0.93749003
65MP0005397_hematopoietic_system_phenotyp0.93749003
66MP0002163_abnormal_gland_morphology0.92750757
67MP0009763_increased_sensitivity_to0.91910157
68MP0002138_abnormal_hepatobiliary_system0.91406164
69MP0003300_gastrointestinal_ulcer0.85052288
70MP0002132_abnormal_respiratory_system0.84027969
71MP0004742_abnormal_vestibular_system0.83420110
72MP0002933_joint_inflammation0.80798418
73MP0002396_abnormal_hematopoietic_system0.79599740
74MP0005390_skeleton_phenotype0.78627745
75MP0003959_abnormal_lean_body0.76015202
76MP0002166_altered_tumor_susceptibility0.73497553
77MP0002019_abnormal_tumor_incidence0.71931165
78MP0003279_aneurysm0.71846019
79MP0003638_abnormal_response/metabolism_0.68916206
80MP0005645_abnormal_hypothalamus_physiol0.68888689
81MP0001986_abnormal_taste_sensitivity0.67654318
82MP0003646_muscle_fatigue0.67633577
83MP0003633_abnormal_nervous_system0.64690055
84MP0000858_altered_metastatic_potential0.63318213
85MP0003075_altered_response_to0.61250000
86MP0005646_abnormal_pituitary_gland0.61087943
87MP0000569_abnormal_digit_pigmentation0.60487124
88MP0008961_abnormal_basal_metabolism0.57863917
89MP0008874_decreased_physiological_sensi0.57139666
90MP0005551_abnormal_eye_electrophysiolog0.57052704
91MP0002168_other_aberrant_phenotype0.55657469
92MP0002006_tumorigenesis0.53612297
93MP0004130_abnormal_muscle_cell0.53211493
94MP0001348_abnormal_lacrimal_gland0.53015741
95MP0001765_abnormal_ion_homeostasis0.52550524
96MP0001663_abnormal_digestive_system0.50689697
97MP0009745_abnormal_behavioral_response0.50680598
98MP0008873_increased_physiological_sensi0.49146927
99MP0004858_abnormal_nervous_system0.48664686
100MP0002971_abnormal_brown_adipose0.48562460

Predicted human phenotypes

RankGene SetZ-score
1Autoimmune hemolytic anemia (HP:0001890)7.54284583
2Abnormality of T cell number (HP:0011839)6.99780183
3Thyroid-stimulating hormone excess (HP:0002925)6.13510958
4T lymphocytopenia (HP:0005403)5.98024340
5Autoimmune thrombocytopenia (HP:0001973)5.92098951
6Aplastic anemia (HP:0001915)5.47135369
7Abnormal delayed hypersensitivity skin test (HP:0002963)5.27603375
8Stomach cancer (HP:0012126)4.99103347
9Increased IgM level (HP:0003496)4.97587937
10Myositis (HP:0100614)4.83759965
11Abnormality of T cells (HP:0002843)4.68563786
12Elevated erythrocyte sedimentation rate (HP:0003565)4.26302269
13Eosinophilia (HP:0001880)4.16332741
14Abnormality of B cell number (HP:0010975)4.14610911
15Orchitis (HP:0100796)4.13122727
16Stomatitis (HP:0010280)4.00789912
17Granulocytopenia (HP:0001913)3.94653643
18Abnormality of macrophages (HP:0004311)3.88659271
19Abnormality of eosinophils (HP:0001879)3.84412690
20Leukocytosis (HP:0001974)3.54550486
21Abnormality of T cell physiology (HP:0011840)3.49676374
22Retrobulbar optic neuritis (HP:0100654)3.47258309
23Optic neuritis (HP:0100653)3.47258309
24Agitation (HP:0000713)3.41372776
25Hypochromic anemia (HP:0001931)3.33467184
26Vasculitis (HP:0002633)3.13683804
27Chronic diarrhea (HP:0002028)3.12018885
28Pustule (HP:0200039)3.11914088
29Hypoproteinemia (HP:0003075)3.11367684
30Volvulus (HP:0002580)3.05154666
31Congenital stationary night blindness (HP:0007642)3.04487967
32IgG deficiency (HP:0004315)3.04418197
33Abnormality of cells of the lymphoid lineage (HP:0012140)2.98312009
34Recurrent bacterial skin infections (HP:0005406)2.97465901
35Severe combined immunodeficiency (HP:0004430)2.97270408
36Recurrent abscess formation (HP:0002722)2.94768053
37Mediastinal lymphadenopathy (HP:0100721)2.82996158
38Recurrent viral infections (HP:0004429)2.80212860
39Intestinal atresia (HP:0011100)2.78299634
40Recurrent fungal infections (HP:0002841)2.67366127
41IgM deficiency (HP:0002850)2.64860353
42Pulmonary infiltrates (HP:0002113)2.63177922
43Abnormality of the alveolar ridges (HP:0006477)2.61488076
44Decreased electroretinogram (ERG) amplitude (HP:0000654)2.59429810
45Encephalitis (HP:0002383)2.57851290
46Eczematoid dermatitis (HP:0000976)2.51744079
47Broad alveolar ridges (HP:0000187)2.51149774
48Meningitis (HP:0001287)2.50766675
49Lymphopenia (HP:0001888)2.41667292
50Joint swelling (HP:0001386)2.40098052
51Combined immunodeficiency (HP:0005387)2.39603565
52Pancreatic islet-cell hyperplasia (HP:0004510)2.32715012
53Gastrointestinal infarctions (HP:0005244)2.32583833
54Keratoconjunctivitis sicca (HP:0001097)2.30445046
55Oligodontia (HP:0000677)2.28689209
56Hypergammaglobulinemia (HP:0010702)2.27545944
573-Methylglutaconic aciduria (HP:0003535)2.27215926
58Abnormality of the aortic arch (HP:0012303)2.26859590
59Urticaria (HP:0001025)2.22752997
60Recurrent bronchitis (HP:0002837)2.18918439
61Lymphoma (HP:0002665)2.18416526
62IgA deficiency (HP:0002720)2.17472241
63Congenital ichthyosiform erythroderma (HP:0007431)2.16932979
64Keratoconjunctivitis (HP:0001096)2.16801175
65Large for gestational age (HP:0001520)2.15065134
66Amyloidosis (HP:0011034)2.13063908
67Recurrent cutaneous fungal infections (HP:0011370)2.12430999
68Chronic mucocutaneous candidiasis (HP:0002728)2.12430999
69Renal cortical cysts (HP:0000803)2.11776226
70Gangrene (HP:0100758)2.10780779
71Mesangial abnormality (HP:0001966)2.05134641
72Oral leukoplakia (HP:0002745)2.03775814
73Recurrent skin infections (HP:0001581)2.03165284
74Chronic obstructive pulmonary disease (HP:0006510)2.03084232
75Obstructive lung disease (HP:0006536)2.03084232
76Thyroiditis (HP:0100646)2.01887720
77Striae distensae (HP:0001065)2.01847492
78Abnormality of the renal cortex (HP:0011035)1.98782817
79Chest pain (HP:0100749)1.98153255
80Increased neuronal autofluorescent lipopigment (HP:0002074)1.95103765
81Attenuation of retinal blood vessels (HP:0007843)1.94042275
82Gaze-evoked nystagmus (HP:0000640)1.93781410
83Recurrent gram-negative bacterial infections (HP:0005420)1.92556057
84Acute hepatic failure (HP:0006554)1.92328133
85Peritonitis (HP:0002586)1.92313548
86Focal motor seizures (HP:0011153)1.92141045
87Abnormality of the pancreatic islet cells (HP:0006476)1.90724458
88Abnormality of endocrine pancreas physiology (HP:0012093)1.90724458
89Metabolic alkalosis (HP:0200114)1.87774872
90Large eyes (HP:0001090)1.86838107
91Anorexia (HP:0002039)1.86773465
92Episodic fever (HP:0001954)1.86600067
93Pancytopenia (HP:0001876)1.84502411
94Severe visual impairment (HP:0001141)1.79175430
95Progressive inability to walk (HP:0002505)1.74635080
96Increased cerebral lipofuscin (HP:0011813)1.74504543
97Ileus (HP:0002595)1.73816238
98Hemoptysis (HP:0002105)1.72058211
99Panhypogammaglobulinemia (HP:0003139)1.71955401
100Poor speech (HP:0002465)1.69239816

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ADRBK25.40911055
2TXK4.39686407
3PINK14.23817131
4MAP4K14.00469097
5ERN13.33038970
6ITK3.23441443
7PASK2.95523816
8PIK3CA2.95360189
9KDR2.67025804
10TAOK32.31324155
11IRAK42.19465784
12CAMKK12.17234966
13ACVR1B2.15045570
14FES2.13981222
15CAMKK22.09169157
16FRK2.01251461
17CSK1.93144903
18GRK61.79701966
19TYRO31.71940312
20JAK31.67282438
21TESK21.66284402
22RIPK41.66108762
23TNK21.56112007
24BTK1.51894052
25BLK1.50057164
26ZAP701.46288565
27LCK1.45655263
28SYK1.41334672
29MAP3K31.39916637
30TAOK11.39816173
31MAP2K31.36234096
32TAOK21.34540473
33MAP3K111.33431508
34ADRBK11.33272707
35TEC1.27109148
36PRKCQ1.23410173
37HCK1.18737172
38IKBKE1.17400749
39LYN1.14884352
40MAPK110.96764023
41STK380.87012491
42IRAK10.84093649
43CLK10.82359065
44IKBKB0.81157969
45TYK20.77387721
46MARK30.70110928
47GRK10.66566987
48TBK10.65807770
49PRKD20.64935006
50FYN0.64816430
51CSF1R0.62074434
52PDK10.58266849
53STK100.56800726
54GRK70.53897066
55RIPK10.53652547
56TGFBR10.53558434
57CAMK10.52867634
58PRKCG0.52360012
59CAMK40.50936972
60RET0.50897717
61JAK20.50720301
62NLK0.49787580
63PIK3CG0.49663205
64NEK60.49601062
65MAPK120.49536160
66IRAK30.46807329
67KIT0.46335293
68NUAK10.45801074
69BCKDK0.42837580
70PRKCH0.41298705
71EIF2AK30.40494851
72JAK10.39753143
73IGF1R0.39650555
74MAP3K100.39163215
75PRKCE0.37587485
76MAP3K10.37365037
77CAMK2A0.37339726
78DAPK20.36754736
79MAP3K140.35041492
80PRKCD0.30471690
81MAPKAPK30.30304234
82PIM10.30221028
83TRPM70.29370142
84PRPF4B0.28914044
85PRKCA0.28513555
86TGFBR20.27365830
87MAPK30.26975267
88NTRK20.25208871
89PRKCB0.23396255
90MAP3K70.22821600
91BMPR1B0.21707275
92PDPK10.20097738
93FGFR10.18155999
94FGR0.18089470
95MAPKAPK20.17739480
96EPHB10.17674658
97ABL10.16576673
98CDK190.15725103
99MAP3K50.15194526
100MAP2K70.14129751

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053324.87722565
2Primary immunodeficiency_Homo sapiens_hsa053404.74647273
3Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046503.79024279
4Allograft rejection_Homo sapiens_hsa053303.64089361
5Antigen processing and presentation_Homo sapiens_hsa046123.62387489
6Autoimmune thyroid disease_Homo sapiens_hsa053203.48571191
7T cell receptor signaling pathway_Homo sapiens_hsa046602.97759136
8Type I diabetes mellitus_Homo sapiens_hsa049402.75168674
9Hematopoietic cell lineage_Homo sapiens_hsa046402.60009146
10NF-kappa B signaling pathway_Homo sapiens_hsa040642.51188357
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.15561385
12Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.05118658
13Dorso-ventral axis formation_Homo sapiens_hsa043202.02166795
14Toll-like receptor signaling pathway_Homo sapiens_hsa046201.94056402
15Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.90411607
16Measles_Homo sapiens_hsa051621.84160963
17Osteoclast differentiation_Homo sapiens_hsa043801.76167869
18Rheumatoid arthritis_Homo sapiens_hsa053231.71917320
19Intestinal immune network for IgA production_Homo sapiens_hsa046721.65171335
20RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.64210469
21NOD-like receptor signaling pathway_Homo sapiens_hsa046211.57530183
22Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.56027489
23Viral myocarditis_Homo sapiens_hsa054161.46391364
24Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.36320613
25Leishmaniasis_Homo sapiens_hsa051401.31317474
26Chemokine signaling pathway_Homo sapiens_hsa040621.28874618
27Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.27420423
28Staphylococcus aureus infection_Homo sapiens_hsa051501.25432102
29TNF signaling pathway_Homo sapiens_hsa046681.20045915
30Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.12262872
31Jak-STAT signaling pathway_Homo sapiens_hsa046301.12138592
32Apoptosis_Homo sapiens_hsa042101.09711410
33Herpes simplex infection_Homo sapiens_hsa051681.09086960
34African trypanosomiasis_Homo sapiens_hsa051431.04248518
35Salmonella infection_Homo sapiens_hsa051321.03589529
36Olfactory transduction_Homo sapiens_hsa047401.02222145
37B cell receptor signaling pathway_Homo sapiens_hsa046620.98255585
38Asthma_Homo sapiens_hsa053100.97816471
39Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.95836134
40Legionellosis_Homo sapiens_hsa051340.94073522
41Tuberculosis_Homo sapiens_hsa051520.91020333
42Malaria_Homo sapiens_hsa051440.88699183
43Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.86310460
44Caffeine metabolism_Homo sapiens_hsa002320.85674207
45Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.79135227
46Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.78002816
47Influenza A_Homo sapiens_hsa051640.76194170
48ABC transporters_Homo sapiens_hsa020100.75627415
49Linoleic acid metabolism_Homo sapiens_hsa005910.71050919
50Proteasome_Homo sapiens_hsa030500.67683006
51Phototransduction_Homo sapiens_hsa047440.64639962
52Nitrogen metabolism_Homo sapiens_hsa009100.64341292
53Leukocyte transendothelial migration_Homo sapiens_hsa046700.63114689
54Toxoplasmosis_Homo sapiens_hsa051450.62099571
55Steroid hormone biosynthesis_Homo sapiens_hsa001400.58305401
56Morphine addiction_Homo sapiens_hsa050320.55282762
57HTLV-I infection_Homo sapiens_hsa051660.47997762
58Glycerolipid metabolism_Homo sapiens_hsa005610.47730338
59alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.46036227
60Epstein-Barr virus infection_Homo sapiens_hsa051690.45122980
61Regulation of autophagy_Homo sapiens_hsa041400.44417551
62Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.42424427
63Sphingolipid metabolism_Homo sapiens_hsa006000.41958808
64MAPK signaling pathway_Homo sapiens_hsa040100.41549684
65Pertussis_Homo sapiens_hsa051330.41211272
66Transcriptional misregulation in cancer_Homo sapiens_hsa052020.40526145
67Hepatitis B_Homo sapiens_hsa051610.40120887
68Shigellosis_Homo sapiens_hsa051310.39173524
69Systemic lupus erythematosus_Homo sapiens_hsa053220.36936999
70Platelet activation_Homo sapiens_hsa046110.36450191
71Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.34356697
72Sphingolipid signaling pathway_Homo sapiens_hsa040710.34089912
73Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.30663527
74Viral carcinogenesis_Homo sapiens_hsa052030.30161451
75SNARE interactions in vesicular transport_Homo sapiens_hsa041300.30117862
76VEGF signaling pathway_Homo sapiens_hsa043700.29358925
77Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.27282252
78Arachidonic acid metabolism_Homo sapiens_hsa005900.27117783
79Endocytosis_Homo sapiens_hsa041440.26042333
80Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.25342790
81Acute myeloid leukemia_Homo sapiens_hsa052210.24156516
82Carbohydrate digestion and absorption_Homo sapiens_hsa049730.23939563
83Retinol metabolism_Homo sapiens_hsa008300.20430342
84Ovarian steroidogenesis_Homo sapiens_hsa049130.18953792
85Pentose phosphate pathway_Homo sapiens_hsa000300.17518720
86Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.16457255
87Chemical carcinogenesis_Homo sapiens_hsa052040.16044701
88Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.15903734
89Lysosome_Homo sapiens_hsa041420.15780023
90Salivary secretion_Homo sapiens_hsa049700.14658029
91Ribosome_Homo sapiens_hsa030100.13655256
92Phagosome_Homo sapiens_hsa041450.12782013
93Phosphatidylinositol signaling system_Homo sapiens_hsa040700.11168858
94Calcium signaling pathway_Homo sapiens_hsa040200.11068785
95Complement and coagulation cascades_Homo sapiens_hsa046100.11002300
96Ras signaling pathway_Homo sapiens_hsa040140.10597126
97Drug metabolism - other enzymes_Homo sapiens_hsa009830.10525279
98Glycerophospholipid metabolism_Homo sapiens_hsa005640.10347613
99Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.10307727
100Glycosaminoglycan degradation_Homo sapiens_hsa005310.09781920

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