TRBV13

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)6.90736904
2negative regulation of cell killing (GO:0031342)6.87876425
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.87876425
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.82932728
5antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.72396323
6antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.30712019
7antigen processing and presentation of endogenous antigen (GO:0019883)6.17885799
8positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)6.12938580
9response to interleukin-15 (GO:0070672)6.04878312
10negative T cell selection (GO:0043383)5.93599136
11negative thymic T cell selection (GO:0045060)5.77511629
12cellular response to interleukin-15 (GO:0071350)5.71364391
13regulation of regulatory T cell differentiation (GO:0045589)5.55256926
14regulation of gamma-delta T cell differentiation (GO:0045586)5.29614245
15regulation of B cell receptor signaling pathway (GO:0050855)5.26717176
16tolerance induction (GO:0002507)5.23580276
17positive regulation of interleukin-2 biosynthetic process (GO:0045086)5.00795233
18regulation of gamma-delta T cell activation (GO:0046643)5.00031641
19leukocyte aggregation (GO:0070486)4.68181649
20regulation of T cell tolerance induction (GO:0002664)4.52699321
21activated T cell proliferation (GO:0050798)4.41115189
22thymic T cell selection (GO:0045061)4.37522190
23negative regulation of lymphocyte mediated immunity (GO:0002707)4.26267813
24negative regulation of T cell mediated immunity (GO:0002710)4.24878525
25T cell selection (GO:0045058)4.18384798
26regulation of alpha-beta T cell proliferation (GO:0046640)4.16119680
27regulation of isotype switching to IgG isotypes (GO:0048302)4.15269081
28regulation of interleukin-2 biosynthetic process (GO:0045076)4.14979321
29T cell migration (GO:0072678)4.12429790
30positive T cell selection (GO:0043368)4.01800244
31positive thymic T cell selection (GO:0045059)3.99221710
32regulation of tolerance induction (GO:0002643)3.84997052
33positive regulation of granulocyte differentiation (GO:0030854)3.83091974
34positive regulation of alpha-beta T cell proliferation (GO:0046641)3.81103345
35regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.77057333
36regulation of natural killer cell mediated immunity (GO:0002715)3.77057333
37negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.76519662
38positive regulation of T cell mediated cytotoxicity (GO:0001916)3.74590830
39modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.73794386
40positive regulation by organism of defense response of other organism involved in symbiotic interact3.73794386
41modulation by symbiont of host immune response (GO:0052553)3.73794386
42positive regulation by symbiont of host defense response (GO:0052509)3.73794386
43modulation by symbiont of host defense response (GO:0052031)3.73794386
44modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.73794386
45regulation of T cell mediated cytotoxicity (GO:0001914)3.72980191
46positive regulation of tolerance induction (GO:0002645)3.69404978
47negative regulation of leukocyte mediated immunity (GO:0002704)3.60766796
48detection of bacterium (GO:0016045)3.59954290
49positive regulation of T cell differentiation in thymus (GO:0033089)3.57878727
50T cell receptor signaling pathway (GO:0050852)3.54385670
51detection of other organism (GO:0098543)3.53843333
52neutrophil activation involved in immune response (GO:0002283)3.51959089
53interferon-gamma production (GO:0032609)3.51217668
54antigen receptor-mediated signaling pathway (GO:0050851)3.48789667
55regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.46928932
56negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.46884937
57negative regulation of T-helper cell differentiation (GO:0045623)3.46884937
58regulation of B cell differentiation (GO:0045577)3.45559058
59T cell homeostasis (GO:0043029)3.45466613
60positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.41603033
61negative regulation of interleukin-12 production (GO:0032695)3.41394434
62cellular response to type I interferon (GO:0071357)3.39607453
63type I interferon signaling pathway (GO:0060337)3.39607453
64regulation of leukocyte mediated cytotoxicity (GO:0001910)3.37743412
65response to type I interferon (GO:0034340)3.37231671
66antigen processing and presentation via MHC class Ib (GO:0002475)3.36173328
67B cell receptor signaling pathway (GO:0050853)3.35748230
68regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.32616999
69positive regulation of B cell differentiation (GO:0045579)3.32241429
70positive regulation of humoral immune response (GO:0002922)3.31830846
71mast cell activation (GO:0045576)3.26601474
72positive regulation of interleukin-4 production (GO:0032753)3.25154234
73positive regulation of isotype switching (GO:0045830)3.22363163
74positive regulation of interleukin-2 production (GO:0032743)3.21564098
75cellular extravasation (GO:0045123)3.17941648
76alpha-beta T cell differentiation (GO:0046632)3.15983790
77negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.12209023
78neutrophil activation (GO:0042119)3.11145754
79regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)3.08439705
80positive regulation of cell killing (GO:0031343)3.05867627
81regulation of cell killing (GO:0031341)3.03531235
82leukocyte degranulation (GO:0043299)3.03494255
83positive regulation of DNA recombination (GO:0045911)3.02320707
84positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.01799034
85positive regulation of T cell mediated immunity (GO:0002711)3.01406991
86positive regulation of natural killer cell mediated immunity (GO:0002717)3.00564328
87alpha-beta T cell activation (GO:0046631)3.00414347
88positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.99815036
89positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.98499412
90regulation of isotype switching (GO:0045191)2.96939186
91myeloid cell activation involved in immune response (GO:0002275)2.96141102
92regulation of alpha-beta T cell activation (GO:0046634)2.96084617
93regulation of T cell mediated immunity (GO:0002709)2.93676354
94myeloid dendritic cell activation (GO:0001773)2.93176991
95negative regulation of innate immune response (GO:0045824)2.92787481
96negative regulation of adaptive immune response (GO:0002820)2.90517738
97regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.89464827
98dendritic cell chemotaxis (GO:0002407)2.89001377
99cytokine biosynthetic process (GO:0042089)2.87902107
100lymphocyte homeostasis (GO:0002260)2.87116104

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse6.48380197
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.81197712
3IRF8_22096565_ChIP-ChIP_GC-B_Human5.06747265
4BP1_19119308_ChIP-ChIP_Hs578T_Human4.75028727
5RUNX_20019798_ChIP-Seq_JUKART_Human3.64078897
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.63544344
7IRF8_21731497_ChIP-ChIP_J774_Mouse3.49309745
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.44847416
9MYB_26560356_Chip-Seq_TH2_Human3.40215258
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.25010352
11STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.24552434
12ELF1_17652178_ChIP-ChIP_JURKAT_Human3.14458507
13SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.01545877
14SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.79884639
15MAF_26560356_Chip-Seq_TH1_Human2.72248165
16STAT4_19710469_ChIP-ChIP_TH1__Mouse2.64068402
17FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.58227270
18MYB_26560356_Chip-Seq_TH1_Human2.56722827
19SPI1_23547873_ChIP-Seq_NB4_Human2.53778223
20UTX_26944678_Chip-Seq_JUKART_Human2.43578415
21IRF8_27001747_Chip-Seq_BMDM_Mouse2.37073063
22SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.36570260
23RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.34382134
24MYB_21317192_ChIP-Seq_ERMYB_Mouse2.27094492
25GATA3_27048872_Chip-Seq_THYMUS_Human2.24277001
26SMAD_19615063_ChIP-ChIP_OVARY_Human2.17218407
27MAF_26560356_Chip-Seq_TH2_Human2.13386224
28NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.10686094
29MYC_22102868_ChIP-Seq_BL_Human2.09722171
30SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.98988597
31SPI1_23127762_ChIP-Seq_K562_Human1.95940595
32E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.90104522
33CIITA_25753668_ChIP-Seq_RAJI_Human1.90059741
34SCL_19346495_ChIP-Seq_HPC-7_Human1.86867699
35FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.81900515
36GATA3_26560356_Chip-Seq_TH2_Human1.80558133
37RUNX1_22412390_ChIP-Seq_EML_Mouse1.80305396
38VDR_21846776_ChIP-Seq_THP-1_Human1.73464786
39MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.69344054
40BRD4_27068464_Chip-Seq_AML-cells_Mouse1.63520095
41ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.62970920
42VDR_24763502_ChIP-Seq_THP-1_Human1.58841107
43RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.57260219
44NOTCH1_21737748_ChIP-Seq_TLL_Human1.54729876
45STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.47080882
46LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.44004317
47VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.41712264
48KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.39593051
49LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.36176479
50CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.33775316
51E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.29459800
52SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.26654993
53TCF7_22412390_ChIP-Seq_EML_Mouse1.24682333
54GATA2_22383799_ChIP-Seq_G1ME_Mouse1.21610577
55NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.19444422
56KDM2B_26808549_Chip-Seq_DND41_Human1.19315655
57BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.19303185
58NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.18332007
59FOXP3_21729870_ChIP-Seq_TREG_Human1.18087602
60VDR_23849224_ChIP-Seq_CD4+_Human1.17758250
61RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.17054234
62KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.14185524
63CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12930556
64FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11424368
65CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08636313
66TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.06521485
67Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.06437687
68TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.06320507
69GATA1_19941827_ChIP-Seq_MEL_Mouse1.05356736
70PU_27001747_Chip-Seq_BMDM_Mouse1.04871007
71PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03919404
72EGR1_19374776_ChIP-ChIP_THP-1_Human1.02387195
73GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.01594834
74KDM2B_26808549_Chip-Seq_SUP-B15_Human1.00775181
75CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00166537
76HOXB4_20404135_ChIP-ChIP_EML_Mouse0.99764584
77PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99447294
78PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98342441
79SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95935778
80VDR_24787735_ChIP-Seq_THP-1_Human0.94750834
81NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.92888885
82RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92374315
83GATA1_22383799_ChIP-Seq_G1ME_Mouse0.90086738
84PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89073606
85FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.88158921
86PU.1_20513432_ChIP-Seq_Bcells_Mouse0.87330391
87BCL6_27268052_Chip-Seq_Bcells_Human0.87090074
88GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86120619
89CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.84375246
90ELK3_25401928_ChIP-Seq_HUVEC_Human0.84281090
91GATA3_26560356_Chip-Seq_TH1_Human0.83816411
92BCOR_27268052_Chip-Seq_Bcells_Human0.82389838
93STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.81728381
94SMRT_27268052_Chip-Seq_Bcells_Human0.81656979
95VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.81199004
96SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.79907117
97KDM2B_26808549_Chip-Seq_JURKAT_Human0.79846597
98GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78812974
99TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.76390403
100RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.75764728

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology4.42500670
2MP0005671_abnormal_response_to4.18321958
3MP0003436_decreased_susceptibility_to3.99065955
4MP0001835_abnormal_antigen_presentation3.93474211
5MP0001800_abnormal_humoral_immune3.35293971
6MP0003724_increased_susceptibility_to3.31638253
7MP0005000_abnormal_immune_tolerance3.15780311
8MP0001790_abnormal_immune_system2.97004845
9MP0005387_immune_system_phenotype2.97004845
10MP0002723_abnormal_immune_serum2.86257360
11MP0001873_stomach_inflammation2.85006317
12MP0002420_abnormal_adaptive_immunity2.80107220
13MP0002148_abnormal_hypersensitivity_rea2.76716195
14MP0001819_abnormal_immune_cell2.75545183
15MP0002452_abnormal_antigen_presenting2.62963769
16MP0009333_abnormal_splenocyte_physiolog2.62581397
17MP0005025_abnormal_response_to2.61082811
18MP0000685_abnormal_immune_system2.59150291
19MP0002419_abnormal_innate_immunity2.54981612
20MP0009785_altered_susceptibility_to2.51813845
21MP0003866_abnormal_defecation2.39739887
22MP0000703_abnormal_thymus_morphology2.38162361
23MP0006082_CNS_inflammation2.37934858
24MP0002398_abnormal_bone_marrow2.37742724
25MP0002405_respiratory_system_inflammati2.36481366
26MP0003300_gastrointestinal_ulcer2.25208493
27MP0000465_gastrointestinal_hemorrhage2.24573770
28MP0000716_abnormal_immune_system2.22044585
29MP0003303_peritoneal_inflammation2.21083479
30MP0010155_abnormal_intestine_physiology2.10733233
31MP0002722_abnormal_immune_system1.97252224
32MP0005310_abnormal_salivary_gland1.95884348
33MP0005464_abnormal_platelet_physiology1.95006667
34MP0000689_abnormal_spleen_morphology1.94261047
35MP0002396_abnormal_hematopoietic_system1.93145740
36MP0002277_abnormal_respiratory_mucosa1.92493919
37MP0004947_skin_inflammation1.80109330
38MP0004381_abnormal_hair_follicle1.79146579
39MP0001845_abnormal_inflammatory_respons1.78705891
40MP0002429_abnormal_blood_cell1.75822425
41MP0001533_abnormal_skeleton_physiology1.73907233
42MP0008260_abnormal_autophagy1.69534074
43MP0003183_abnormal_peptide_metabolism1.69265186
44MP0002166_altered_tumor_susceptibility1.46082109
45MP0008469_abnormal_protein_level1.45423783
46MP0001851_eye_inflammation1.31042057
47MP0002933_joint_inflammation1.30340510
48MP0003806_abnormal_nucleotide_metabolis1.26953927
49MP0009764_decreased_sensitivity_to1.25666333
50MP0005075_abnormal_melanosome_morpholog1.23410738
51MP0001348_abnormal_lacrimal_gland1.21018689
52MP0002132_abnormal_respiratory_system1.16327121
53MP0002006_tumorigenesis1.15481637
54MP0002138_abnormal_hepatobiliary_system1.10018661
55MP0003191_abnormal_cellular_cholesterol1.03713997
56MP0002163_abnormal_gland_morphology0.98712026
57MP0001663_abnormal_digestive_system0.93230086
58MP0001853_heart_inflammation0.90209859
59MP0000490_abnormal_crypts_of0.83526275
60MP0002998_abnormal_bone_remodeling0.81398889
61MP0001986_abnormal_taste_sensitivity0.80193273
62MP0009278_abnormal_bone_marrow0.79470170
63MP0002019_abnormal_tumor_incidence0.79438978
64MP0003828_pulmonary_edema0.78398882
65MP0000858_altered_metastatic_potential0.78262949
66MP0005166_decreased_susceptibility_to0.76214600
67MP0003075_altered_response_to0.76141296
68MP0003448_altered_tumor_morphology0.75644495
69MP0004883_abnormal_blood_vessel0.75571442
70MP0003045_fibrosis0.75439501
71MP0002693_abnormal_pancreas_physiology0.71308845
72MP0009763_increased_sensitivity_to0.71213034
73MP0003221_abnormal_cardiomyocyte_apopto0.67709753
74MP0003172_abnormal_lysosome_physiology0.63533266
75MP0004808_abnormal_hematopoietic_stem0.63036753
76MP0005390_skeleton_phenotype0.59618585
77MP0002928_abnormal_bile_duct0.59130043
78MP0005083_abnormal_biliary_tract0.59106713
79MP0004510_myositis0.57070265
80MP0005164_abnormal_response_to0.56514180
81MP0006035_abnormal_mitochondrial_morpho0.56378539
82MP0003690_abnormal_glial_cell0.55963899
83MP0003795_abnormal_bone_structure0.53432170
84MP0005319_abnormal_enzyme/_coenzyme0.52811913
85MP0008873_increased_physiological_sensi0.52580223
86MP0000249_abnormal_blood_vessel0.51834363
87MP0009765_abnormal_xenobiotic_induced0.51516147
88MP0004130_abnormal_muscle_cell0.51305404
89MP0000604_amyloidosis0.49894550
90MP0008874_decreased_physiological_sensi0.49169192
91MP0003252_abnormal_bile_duct0.48745727
92MP0000920_abnormal_myelination0.47701535
93MP0003633_abnormal_nervous_system0.47647714
94MP0008872_abnormal_physiological_respon0.47271090
95MP0005381_digestive/alimentary_phenotyp0.46394615
96MP0008057_abnormal_DNA_replication0.44017153
97MP0005376_homeostasis/metabolism_phenot0.43446168
98MP0002332_abnormal_exercise_endurance0.42057011
99MP0001545_abnormal_hematopoietic_system0.41110521
100MP0005397_hematopoietic_system_phenotyp0.41110521

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)5.93069306
2T lymphocytopenia (HP:0005403)5.77313575
3Stomatitis (HP:0010280)5.65939175
4Abnormality of T cell number (HP:0011839)5.34707747
5Eczematoid dermatitis (HP:0000976)5.24904517
6Myositis (HP:0100614)4.99321230
7Encephalitis (HP:0002383)4.57931655
8Autoimmune hemolytic anemia (HP:0001890)4.52991145
9Orchitis (HP:0100796)4.39029036
10Retrobulbar optic neuritis (HP:0100654)4.35263983
11Optic neuritis (HP:0100653)4.35263983
12Abnormality of T cells (HP:0002843)4.31444788
13Recurrent fungal infections (HP:0002841)4.26305145
14Abnormal delayed hypersensitivity skin test (HP:0002963)4.20747858
15Recurrent abscess formation (HP:0002722)4.17420132
16Recurrent bacterial skin infections (HP:0005406)4.13925725
17Chronic mucocutaneous candidiasis (HP:0002728)4.01131373
18Recurrent cutaneous fungal infections (HP:0011370)4.01131373
19Severe combined immunodeficiency (HP:0004430)3.91582646
20Gastrointestinal infarctions (HP:0005244)3.77431220
21Granulocytopenia (HP:0001913)3.76427202
22Abnormality of macrophages (HP:0004311)3.76421936
23Pustule (HP:0200039)3.67125249
24Panhypogammaglobulinemia (HP:0003139)3.59318397
25Chronic diarrhea (HP:0002028)3.56641353
26IgM deficiency (HP:0002850)3.56490601
27Meningitis (HP:0001287)3.55212864
28Abnormality of eosinophils (HP:0001879)3.48978115
29Eosinophilia (HP:0001880)3.46645802
30Chronic obstructive pulmonary disease (HP:0006510)3.43755939
31Obstructive lung disease (HP:0006536)3.43755939
32IgG deficiency (HP:0004315)3.42384670
33Leukocytosis (HP:0001974)3.41409723
34Increased IgM level (HP:0003496)3.39811969
35Keratoconjunctivitis sicca (HP:0001097)3.35563188
36Recurrent bronchitis (HP:0002837)3.32319080
37Recurrent skin infections (HP:0001581)3.31919188
38Vasculitis (HP:0002633)3.31278466
39Mediastinal lymphadenopathy (HP:0100721)3.26722506
40Spontaneous hematomas (HP:0007420)3.17885563
41Abnormality of T cell physiology (HP:0011840)3.13209181
42Keratoconjunctivitis (HP:0001096)3.12198166
43Recurrent viral infections (HP:0004429)3.09094609
44Pulmonary infiltrates (HP:0002113)3.07103317
45Recurrent gram-negative bacterial infections (HP:0005420)3.06491535
46Combined immunodeficiency (HP:0005387)3.04274366
47Lymphopenia (HP:0001888)2.98186501
48Chest pain (HP:0100749)2.94434483
49Abnormality of cells of the lymphoid lineage (HP:0012140)2.83398148
50Hemoptysis (HP:0002105)2.81631969
51Increased IgE level (HP:0003212)2.80629198
52Hypochromic microcytic anemia (HP:0004840)2.80053248
53Urticaria (HP:0001025)2.80010176
54Inflammation of the large intestine (HP:0002037)2.75888477
55Joint swelling (HP:0001386)2.74542319
56Abnormality of lateral ventricle (HP:0030047)2.66821672
57Gastrointestinal inflammation (HP:0004386)2.65942390
58Agammaglobulinemia (HP:0004432)2.63373540
59Hypochromic anemia (HP:0001931)2.53714347
60Pulmonary embolism (HP:0002204)2.49521615
61Microcytic anemia (HP:0001935)2.48749149
62Lymphoma (HP:0002665)2.39217205
63Anorexia (HP:0002039)2.37072925
64Amaurosis fugax (HP:0100576)2.33119473
65Hypoplasia of the thymus (HP:0000778)2.32563606
66Arterial thrombosis (HP:0004420)2.30600532
67Hypergammaglobulinemia (HP:0010702)2.30530442
68Prolonged bleeding time (HP:0003010)2.28621305
69Segmental peripheral demyelination/remyelination (HP:0003481)2.27889615
70Epistaxis (HP:0000421)2.26292729
71Abnormality of B cell number (HP:0010975)2.22238365
72Aplasia/Hypoplasia of the thymus (HP:0010515)2.17693919
73Absent rod-and cone-mediated responses on ERG (HP:0007688)2.17449125
74Abnormality of the pleura (HP:0002103)2.17224470
75Stomach cancer (HP:0012126)2.16913735
76Vertigo (HP:0002321)2.16669910
77Gangrene (HP:0100758)2.15822804
78B lymphocytopenia (HP:0010976)2.14779352
79Gingivitis (HP:0000230)2.13553154
80Fatigue (HP:0012378)2.13146357
81Sepsis (HP:0100806)2.11850740
82Skin rash (HP:0000988)2.10199595
83Colitis (HP:0002583)2.07889667
84Papilledema (HP:0001085)2.07763375
85Hepatosplenomegaly (HP:0001433)2.06807722
86Petechiae (HP:0000967)2.06637965
87Acute hepatic failure (HP:0006554)2.05909245
88Papilloma (HP:0012740)2.04084372
89Verrucae (HP:0200043)2.04084372
90Alveolar cell carcinoma (HP:0006519)2.03011599
91Basal cell carcinoma (HP:0002671)2.00571659
92Thyroiditis (HP:0100646)2.00172458
93Gingival bleeding (HP:0000225)1.98647071
94Glomerulopathy (HP:0100820)1.97571100
95Episodic fever (HP:0001954)1.94965372
96Cellulitis (HP:0100658)1.91992902
97Neoplasm of the tracheobronchial system (HP:0100552)1.91621158
98Chronic otitis media (HP:0000389)1.90916726
99Recurrent sinusitis (HP:0011108)1.89844573
100Skin ulcer (HP:0200042)1.89222590

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK5.34802686
2MAP4K14.63649243
3RIPK42.86868690
4PRPF4B2.83678788
5TNK22.81941850
6TYK22.71385817
7FES2.68632050
8MAP2K32.68186387
9ZAP702.48371599
10CSK2.33618071
11MAP3K132.33151991
12ITK2.24179033
13GRK62.14112262
14BTK1.99333987
15TAOK31.88222056
16ERN11.77324775
17JAK31.73287036
18LCK1.71460514
19BLK1.66635214
20IKBKE1.65099073
21HCK1.64754668
22PASK1.63145184
23MAP3K31.58934543
24IRAK41.57844679
25MAP3K111.57701406
26SYK1.57142597
27SIK31.52569810
28EPHB11.51880580
29JAK11.48403976
30MAP3K141.46854617
31TEC1.34753029
32TAOK21.30422306
33STK101.29732407
34MAP3K121.29153694
35MAP3K61.28569269
36CLK11.22186655
37LYN1.21368466
38FGFR41.14567024
39JAK21.09501563
40PRKCQ1.07525985
41STK161.04688287
42NLK1.03633209
43CAMKK21.02752126
44TBK11.02537595
45CDK191.01331009
46KIT1.01207203
47CAMKK11.00345902
48MAP2K60.95497472
49SMG10.92779111
50PTK60.88311315
51NEK90.87519212
52MAP3K70.86979928
53SRPK10.84047106
54MARK30.83828394
55FGFR30.83736101
56TAOK10.82222331
57MAP3K10.81694294
58IKBKB0.81154205
59MAP3K50.80605834
60INSRR0.76093319
61TESK20.74766012
62CSF1R0.74589864
63NUAK10.74435936
64MAPK110.73497166
65SIK20.67913262
66PDK10.65867925
67FYN0.64894308
68MAP2K40.63685161
69EIF2AK10.61632002
70PIM10.55631072
71FGR0.53254808
72HIPK20.51616486
73MAPK120.50907375
74CDK40.50675804
75PIK3CG0.50520647
76KSR20.50157982
77GRK70.50097895
78YES10.48502858
79LRRK20.47816258
80EIF2AK30.45569899
81MARK20.45141313
82TYRO30.45131712
83STK380.43280547
84PTK2B0.42104876
85RAF10.41029501
86TGFBR20.40063500
87RET0.40000800
88CCNB10.39900623
89MAPK70.34586268
90MOS0.33223005
91MAPKAPK20.28837025
92EPHA30.28403197
93IRAK10.28351672
94TLK10.25842185
95NEK60.25526237
96MAP3K80.25069028
97INSR0.22744635
98PRKCD0.21052156
99KDR0.19420774
100PDGFRB0.19203444

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.11938626
2T cell receptor signaling pathway_Homo sapiens_hsa046603.27405756
3Graft-versus-host disease_Homo sapiens_hsa053323.14351089
4Allograft rejection_Homo sapiens_hsa053303.12057340
5Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046503.10698922
6Autoimmune thyroid disease_Homo sapiens_hsa053203.08666479
7Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.49094267
8Measles_Homo sapiens_hsa051622.48981196
9Osteoclast differentiation_Homo sapiens_hsa043802.44465814
10Antigen processing and presentation_Homo sapiens_hsa046122.25507995
11Leishmaniasis_Homo sapiens_hsa051402.15357170
12Type I diabetes mellitus_Homo sapiens_hsa049402.11299697
13Hematopoietic cell lineage_Homo sapiens_hsa046401.96471462
14Jak-STAT signaling pathway_Homo sapiens_hsa046301.94107884
15B cell receptor signaling pathway_Homo sapiens_hsa046621.88855718
16Viral myocarditis_Homo sapiens_hsa054161.84993792
17NF-kappa B signaling pathway_Homo sapiens_hsa040641.84615201
18NOD-like receptor signaling pathway_Homo sapiens_hsa046211.83208367
19Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.70574283
20Acute myeloid leukemia_Homo sapiens_hsa052211.69160558
21Intestinal immune network for IgA production_Homo sapiens_hsa046721.66990097
22RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.66482308
23Toll-like receptor signaling pathway_Homo sapiens_hsa046201.65946593
24Herpes simplex infection_Homo sapiens_hsa051681.60385030
25Staphylococcus aureus infection_Homo sapiens_hsa051501.56881489
26Chemokine signaling pathway_Homo sapiens_hsa040621.51718973
27Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.50471368
28Hepatitis B_Homo sapiens_hsa051611.40365980
29Tuberculosis_Homo sapiens_hsa051521.38651146
30Influenza A_Homo sapiens_hsa051641.29521842
31Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.27942733
32Toxoplasmosis_Homo sapiens_hsa051451.24641480
33Leukocyte transendothelial migration_Homo sapiens_hsa046701.23587357
34Non-small cell lung cancer_Homo sapiens_hsa052231.23028393
35Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.21663939
36Malaria_Homo sapiens_hsa051441.16657433
37TNF signaling pathway_Homo sapiens_hsa046681.14618751
38Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.12706545
39Asthma_Homo sapiens_hsa053101.10402869
40Shigellosis_Homo sapiens_hsa051311.07831634
41SNARE interactions in vesicular transport_Homo sapiens_hsa041301.05463270
42Pancreatic cancer_Homo sapiens_hsa052121.03771049
43Legionellosis_Homo sapiens_hsa051340.98965257
44Prolactin signaling pathway_Homo sapiens_hsa049170.98351692
45Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.97568895
46Platelet activation_Homo sapiens_hsa046110.96574625
47Hepatitis C_Homo sapiens_hsa051600.93756316
48African trypanosomiasis_Homo sapiens_hsa051430.92812057
49Epstein-Barr virus infection_Homo sapiens_hsa051690.89798937
50Regulation of autophagy_Homo sapiens_hsa041400.85718331
51Apoptosis_Homo sapiens_hsa042100.85664908
52HTLV-I infection_Homo sapiens_hsa051660.84387470
53Chronic myeloid leukemia_Homo sapiens_hsa052200.83240829
54Fatty acid biosynthesis_Homo sapiens_hsa000610.82707051
55Sphingolipid signaling pathway_Homo sapiens_hsa040710.82648246
56Pertussis_Homo sapiens_hsa051330.80694209
57VEGF signaling pathway_Homo sapiens_hsa043700.78983805
58Viral carcinogenesis_Homo sapiens_hsa052030.77249505
59Adipocytokine signaling pathway_Homo sapiens_hsa049200.76846902
60Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.76682780
61Rheumatoid arthritis_Homo sapiens_hsa053230.68196225
62Phagosome_Homo sapiens_hsa041450.67420385
63Other glycan degradation_Homo sapiens_hsa005110.65756168
64FoxO signaling pathway_Homo sapiens_hsa040680.63303804
65Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.63163350
66Phosphatidylinositol signaling system_Homo sapiens_hsa040700.62977834
67Colorectal cancer_Homo sapiens_hsa052100.61345963
68Endometrial cancer_Homo sapiens_hsa052130.58580354
69AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.57068593
70Phospholipase D signaling pathway_Homo sapiens_hsa040720.55602866
71Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.54649807
72Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.53567470
73Endocytosis_Homo sapiens_hsa041440.51391760
74Neurotrophin signaling pathway_Homo sapiens_hsa047220.51113732
75MAPK signaling pathway_Homo sapiens_hsa040100.48760764
76Salmonella infection_Homo sapiens_hsa051320.47839243
77Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.46569541
78Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.41741010
79Circadian rhythm_Homo sapiens_hsa047100.41544910
80Choline metabolism in cancer_Homo sapiens_hsa052310.39455915
81mTOR signaling pathway_Homo sapiens_hsa041500.38023511
82Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.36037744
83Renal cell carcinoma_Homo sapiens_hsa052110.35766730
84Insulin resistance_Homo sapiens_hsa049310.33578492
85HIF-1 signaling pathway_Homo sapiens_hsa040660.33138930
86Ras signaling pathway_Homo sapiens_hsa040140.29885509
87ABC transporters_Homo sapiens_hsa020100.28898292
88Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.28170004
89Longevity regulating pathway - mammal_Homo sapiens_hsa042110.27650348
90Inositol phosphate metabolism_Homo sapiens_hsa005620.27475981
91Regulation of actin cytoskeleton_Homo sapiens_hsa048100.26114964
92Transcriptional misregulation in cancer_Homo sapiens_hsa052020.25425999
93Prostate cancer_Homo sapiens_hsa052150.25243820
94GnRH signaling pathway_Homo sapiens_hsa049120.24507882
95Carbohydrate digestion and absorption_Homo sapiens_hsa049730.21625052
96Non-homologous end-joining_Homo sapiens_hsa034500.21026038
97Notch signaling pathway_Homo sapiens_hsa043300.20804709
98Glycerophospholipid metabolism_Homo sapiens_hsa005640.19859993
99Long-term depression_Homo sapiens_hsa047300.18708500
100Rap1 signaling pathway_Homo sapiens_hsa040150.17710018

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