

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | negative T cell selection (GO:0043383) | 8.19766861 |
| 2 | positive regulation of gamma-delta T cell activation (GO:0046645) | 7.85605184 |
| 3 | negative thymic T cell selection (GO:0045060) | 7.55591223 |
| 4 | positive T cell selection (GO:0043368) | 7.54400968 |
| 5 | positive thymic T cell selection (GO:0045059) | 7.18128049 |
| 6 | regulation of gamma-delta T cell differentiation (GO:0045586) | 7.11945966 |
| 7 | negative regulation of cell killing (GO:0031342) | 6.85213217 |
| 8 | negative regulation of leukocyte mediated cytotoxicity (GO:0001911) | 6.85213217 |
| 9 | antigen processing and presentation of endogenous peptide antigen (GO:0002483) | 6.74317764 |
| 10 | antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885) | 6.74317764 |
| 11 | T cell selection (GO:0045058) | 6.62411444 |
| 12 | thymic T cell selection (GO:0045061) | 6.59358486 |
| 13 | interferon-gamma production (GO:0032609) | 6.51667075 |
| 14 | positive regulation of interleukin-2 biosynthetic process (GO:0045086) | 6.47768684 |
| 15 | positive regulation of antigen receptor-mediated signaling pathway (GO:0050857) | 6.44902770 |
| 16 | cytidine metabolic process (GO:0046087) | 6.40960226 |
| 17 | cytidine catabolic process (GO:0006216) | 6.40960226 |
| 18 | cytidine deamination (GO:0009972) | 6.40960226 |
| 19 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G | 6.39312396 |
| 20 | regulation of gamma-delta T cell activation (GO:0046643) | 6.36905342 |
| 21 | pyrimidine ribonucleoside catabolic process (GO:0046133) | 5.93416166 |
| 22 | regulation of isotype switching to IgG isotypes (GO:0048302) | 5.91520172 |
| 23 | response to interleukin-15 (GO:0070672) | 5.77275456 |
| 24 | T cell receptor signaling pathway (GO:0050852) | 5.73357118 |
| 25 | antigen processing and presentation of endogenous antigen (GO:0019883) | 5.56952712 |
| 26 | activated T cell proliferation (GO:0050798) | 5.22779680 |
| 27 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 5.21236203 |
| 28 | cellular response to interleukin-15 (GO:0071350) | 5.04238315 |
| 29 | regulation of T cell tolerance induction (GO:0002664) | 4.95718753 |
| 30 | T cell migration (GO:0072678) | 4.93294025 |
| 31 | T cell costimulation (GO:0031295) | 4.92951898 |
| 32 | lymphocyte costimulation (GO:0031294) | 4.85374701 |
| 33 | regulation of interleukin-12 biosynthetic process (GO:0045075) | 4.85098658 |
| 34 | leukocyte aggregation (GO:0070486) | 4.76445121 |
| 35 | DNA deamination (GO:0045006) | 4.73655616 |
| 36 | positive regulation of B cell differentiation (GO:0045579) | 4.69047259 |
| 37 | regulation of regulatory T cell differentiation (GO:0045589) | 4.66660300 |
| 38 | antigen receptor-mediated signaling pathway (GO:0050851) | 4.66412119 |
| 39 | regulation of interleukin-2 biosynthetic process (GO:0045076) | 4.59767029 |
| 40 | positive regulation of interleukin-2 production (GO:0032743) | 4.58302775 |
| 41 | V(D)J recombination (GO:0033151) | 4.51345254 |
| 42 | regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923) | 4.40279486 |
| 43 | regulation of alpha-beta T cell proliferation (GO:0046640) | 4.32848441 |
| 44 | antigen processing and presentation via MHC class Ib (GO:0002475) | 4.30254328 |
| 45 | regulation of T cell receptor signaling pathway (GO:0050856) | 4.24741747 |
| 46 | alpha-beta T cell differentiation (GO:0046632) | 4.18418394 |
| 47 | positive regulation of tolerance induction (GO:0002645) | 4.16624123 |
| 48 | alpha-beta T cell activation (GO:0046631) | 4.13703948 |
| 49 | regulation of antigen receptor-mediated signaling pathway (GO:0050854) | 4.11144789 |
| 50 | positive regulation of isotype switching (GO:0045830) | 4.06987947 |
| 51 | negative regulation of T cell mediated immunity (GO:0002710) | 4.03786468 |
| 52 | T cell differentiation (GO:0030217) | 3.99352505 |
| 53 | Arp2/3 complex-mediated actin nucleation (GO:0034314) | 3.96981618 |
| 54 | positive regulation of humoral immune response (GO:0002922) | 3.90457374 |
| 55 | mast cell activation (GO:0045576) | 3.88486185 |
| 56 | positive regulation of alpha-beta T cell proliferation (GO:0046641) | 3.85210968 |
| 57 | negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665) | 3.83812119 |
| 58 | ribosomal small subunit assembly (GO:0000028) | 3.82534166 |
| 59 | regulation of B cell receptor signaling pathway (GO:0050855) | 3.78905417 |
| 60 | negative regulation of B cell proliferation (GO:0030889) | 3.76546250 |
| 61 | negative regulation of leukocyte mediated immunity (GO:0002704) | 3.72697295 |
| 62 | tolerance induction (GO:0002507) | 3.72370651 |
| 63 | regulation of isotype switching (GO:0045191) | 3.72155614 |
| 64 | regulation of T cell mediated cytotoxicity (GO:0001914) | 3.69099574 |
| 65 | regulation of tolerance induction (GO:0002643) | 3.59949136 |
| 66 | viral transcription (GO:0019083) | 3.59095042 |
| 67 | positive regulation of immunoglobulin mediated immune response (GO:0002891) | 3.58873023 |
| 68 | positive regulation of B cell mediated immunity (GO:0002714) | 3.58873023 |
| 69 | positive regulation of T cell mediated cytotoxicity (GO:0001916) | 3.55418710 |
| 70 | adaptation of signaling pathway (GO:0023058) | 3.52854847 |
| 71 | T cell homeostasis (GO:0043029) | 3.52687438 |
| 72 | negative regulation of B cell activation (GO:0050869) | 3.52353933 |
| 73 | regulation of interleukin-2 production (GO:0032663) | 3.50699663 |
| 74 | regulation of response to interferon-gamma (GO:0060330) | 3.49673201 |
| 75 | regulation of interferon-gamma-mediated signaling pathway (GO:0060334) | 3.47530358 |
| 76 | positive regulation of DNA recombination (GO:0045911) | 3.46978813 |
| 77 | NIK/NF-kappaB signaling (GO:0038061) | 3.45282244 |
| 78 | translational termination (GO:0006415) | 3.41280535 |
| 79 | T cell activation (GO:0042110) | 3.40862940 |
| 80 | positive regulation of defense response to virus by host (GO:0002230) | 3.35446800 |
| 81 | regulation of natural killer cell mediated cytotoxicity (GO:0042269) | 3.35372716 |
| 82 | regulation of natural killer cell mediated immunity (GO:0002715) | 3.35372716 |
| 83 | regulation of immunoglobulin mediated immune response (GO:0002889) | 3.35079305 |
| 84 | B cell receptor signaling pathway (GO:0050853) | 3.34763145 |
| 85 | cellular response to interleukin-4 (GO:0071353) | 3.34229434 |
| 86 | negative regulation of viral genome replication (GO:0045071) | 3.33924839 |
| 87 | positive regulation of natural killer cell mediated cytotoxicity (GO:0045954) | 3.33349248 |
| 88 | positive regulation of natural killer cell mediated immunity (GO:0002717) | 3.33349248 |
| 89 | regulation of leukocyte mediated cytotoxicity (GO:0001910) | 3.30694171 |
| 90 | negative regulation of interleukin-12 production (GO:0032695) | 3.30338172 |
| 91 | positive regulation of type I interferon-mediated signaling pathway (GO:0060340) | 3.30210444 |
| 92 | regulation of B cell mediated immunity (GO:0002712) | 3.28214059 |
| 93 | actin nucleation (GO:0045010) | 3.26148808 |
| 94 | mast cell activation involved in immune response (GO:0002279) | 3.25667048 |
| 95 | mast cell degranulation (GO:0043303) | 3.25667048 |
| 96 | JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397) | 3.24953945 |
| 97 | positive regulation of leukocyte mediated cytotoxicity (GO:0001912) | 3.24343385 |
| 98 | negative regulation of erythrocyte differentiation (GO:0045647) | 3.24016494 |
| 99 | negative regulation of lymphocyte mediated immunity (GO:0002707) | 3.23917442 |
| 100 | regulation of type I interferon-mediated signaling pathway (GO:0060338) | 3.21465748 |
| 101 | regulation of defense response to virus by virus (GO:0050690) | 3.20590368 |
| 102 | interferon-gamma secretion (GO:0072643) | 3.19953267 |
| 103 | immune response-activating cell surface receptor signaling pathway (GO:0002429) | 3.19573344 |
| 104 | positive regulation of calcium-mediated signaling (GO:0050850) | 3.17176072 |
| 105 | regulation of immunoglobulin production (GO:0002637) | 3.15292667 |
| 106 | pyrimidine nucleoside catabolic process (GO:0046135) | 3.14410435 |
| 107 | T cell proliferation (GO:0042098) | 3.14220264 |
| 108 | negative regulation of T cell receptor signaling pathway (GO:0050860) | 3.12011512 |
| 109 | response to interleukin-4 (GO:0070670) | 3.11131566 |
| 110 | negative regulation of thymocyte apoptotic process (GO:0070244) | 3.09474406 |
| 111 | detection of bacterium (GO:0016045) | 3.08069422 |
| 112 | positive regulation of immunoglobulin production (GO:0002639) | 3.07147068 |
| 113 | positive regulation of granulocyte differentiation (GO:0030854) | 3.06891303 |
| 114 | ribosomal small subunit biogenesis (GO:0042274) | 3.06389982 |
| 115 | negative regulation of cytokine production involved in immune response (GO:0002719) | 3.05704331 |
| 116 | chemokine-mediated signaling pathway (GO:0070098) | 3.05222922 |
| 117 | lymphocyte homeostasis (GO:0002260) | 3.04541133 |
| 118 | CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369) | 3.04532308 |
| 119 | regulation of B cell differentiation (GO:0045577) | 3.03397745 |
| 120 | dendritic cell chemotaxis (GO:0002407) | 3.02551589 |
| 121 | regulation of chronic inflammatory response (GO:0002676) | 3.02312050 |
| 122 | positive regulation of T cell activation (GO:0050870) | 3.01755846 |
| 123 | leukocyte cell-cell adhesion (GO:0007159) | 3.01125049 |
| 124 | natural killer cell differentiation (GO:0001779) | 3.00890010 |
| 125 | detection of other organism (GO:0098543) | 3.00138790 |
| 126 | negative regulation of adaptive immune response (GO:0002820) | 2.98276398 |
| 127 | regulation of alpha-beta T cell activation (GO:0046634) | 2.97326854 |
| 128 | natural killer cell activation (GO:0030101) | 2.96791206 |
| 129 | positive regulation of T cell differentiation in thymus (GO:0033089) | 2.96502514 |
| 130 | regulation of cell killing (GO:0031341) | 2.94854274 |
| 131 | positive regulation of inflammatory response to antigenic stimulus (GO:0002863) | 2.94470699 |
| 132 | translational elongation (GO:0006414) | 2.93536672 |
| 133 | positive regulation of natural killer cell differentiation (GO:0032825) | 2.92192876 |
| 134 | negative regulation of adaptive immune response based on somatic recombination of immune receptors b | 2.92123162 |
| 135 | regulation of lymphocyte chemotaxis (GO:1901623) | 2.91614574 |
| 136 | positive regulation of cell killing (GO:0031343) | 2.90055478 |
| 137 | negative regulation of antigen receptor-mediated signaling pathway (GO:0050858) | 2.90007175 |
| 138 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 2.89104130 |
| 139 | positive regulation of T cell differentiation (GO:0045582) | 2.87101021 |
| 140 | respiratory burst (GO:0045730) | 2.86817425 |
| 141 | regulation of thymocyte apoptotic process (GO:0070243) | 2.86808464 |
| 142 | positive regulation of interleukin-4 production (GO:0032753) | 2.86036153 |
| 143 | Peyers patch development (GO:0048541) | 2.85864055 |
| 144 | negative regulation of glycoprotein biosynthetic process (GO:0010561) | 2.85615742 |
| 145 | type I interferon signaling pathway (GO:0060337) | 2.85220878 |
| 146 | cellular response to type I interferon (GO:0071357) | 2.85220878 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 7.61369921 |
| 2 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 5.89222758 |
| 3 | E2F7_22180533_ChIP-Seq_HELA_Human | 5.04457579 |
| 4 | MYC_22102868_ChIP-Seq_BL_Human | 4.27460419 |
| 5 | FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse | 3.59610330 |
| 6 | RUNX_20019798_ChIP-Seq_JUKART_Human | 3.56174980 |
| 7 | STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 3.47408809 |
| 8 | MYB_26560356_Chip-Seq_TH2_Human | 3.23857659 |
| 9 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 3.20763712 |
| 10 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 3.18088246 |
| 11 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 3.03858770 |
| 12 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 3.01297316 |
| 13 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 2.99569669 |
| 14 | MAF_26560356_Chip-Seq_TH1_Human | 2.95857316 |
| 15 | UTX_26944678_Chip-Seq_JUKART_Human | 2.81788806 |
| 16 | MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 2.70131283 |
| 17 | MYB_26560356_Chip-Seq_TH1_Human | 2.67665438 |
| 18 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 2.63809645 |
| 19 | VDR_21846776_ChIP-Seq_THP-1_Human | 2.61582673 |
| 20 | GATA1_22025678_ChIP-Seq_K562_Human | 2.37849702 |
| 21 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 2.37644622 |
| 22 | KDM2B_26808549_Chip-Seq_HPB-ALL_Human | 2.36195363 |
| 23 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 2.31030083 |
| 24 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 2.25082633 |
| 25 | TCF7_22412390_ChIP-Seq_EML_Mouse | 2.20035494 |
| 26 | MAF_26560356_Chip-Seq_TH2_Human | 2.18179344 |
| 27 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 2.07823970 |
| 28 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 2.04017665 |
| 29 | GATA3_27048872_Chip-Seq_THYMUS_Human | 2.01875219 |
| 30 | KDM2B_26808549_Chip-Seq_DND41_Human | 1.98379998 |
| 31 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 1.98196662 |
| 32 | E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 1.85038659 |
| 33 | RUNX1_22412390_ChIP-Seq_EML_Mouse | 1.82588568 |
| 34 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.79708829 |
| 35 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.79572958 |
| 36 | CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human | 1.79270080 |
| 37 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.78995127 |
| 38 | VDR_24763502_ChIP-Seq_THP-1_Human | 1.76377161 |
| 39 | SCL_19346495_ChIP-Seq_HPC-7_Human | 1.71316959 |
| 40 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 1.68644824 |
| 41 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.62683131 |
| 42 | SPI1_23547873_ChIP-Seq_NB4_Human | 1.60275004 |
| 43 | NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse | 1.59026696 |
| 44 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 1.57945691 |
| 45 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.57857325 |
| 46 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 1.53868336 |
| 47 | SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse | 1.53166890 |
| 48 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.46098905 |
| 49 | BRD4_27068464_Chip-Seq_AML-cells_Mouse | 1.44377571 |
| 50 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 1.40272959 |
| 51 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.38714753 |
| 52 | KDM2B_26808549_Chip-Seq_JURKAT_Human | 1.38236590 |
| 53 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 1.35535992 |
| 54 | MEIS1_20887958_ChIP-Seq_HPC-7_Mouse | 1.33413372 |
| 55 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 1.32107861 |
| 56 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.31326069 |
| 57 | IRF8_27001747_Chip-Seq_BMDM_Mouse | 1.30665041 |
| 58 | RUNX1_17652178_ChIP-ChIP_JURKAT_Human | 1.27836232 |
| 59 | VDR_23849224_ChIP-Seq_CD4+_Human | 1.25978683 |
| 60 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 1.25766743 |
| 61 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 1.23958732 |
| 62 | SPI1_23127762_ChIP-Seq_K562_Human | 1.22463779 |
| 63 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.22090543 |
| 64 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 1.21588184 |
| 65 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 1.18329285 |
| 66 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 1.16628204 |
| 67 | GATA2_22383799_ChIP-Seq_G1ME_Mouse | 1.15820206 |
| 68 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 1.12560308 |
| 69 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.12118246 |
| 70 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 1.11345899 |
| 71 | PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.08797408 |
| 72 | TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse | 1.08121613 |
| 73 | VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human | 1.07995538 |
| 74 | GATA3_26560356_Chip-Seq_TH2_Human | 1.07895076 |
| 75 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.07730664 |
| 76 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 1.07205499 |
| 77 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.06560560 |
| 78 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.06430182 |
| 79 | PU_27001747_Chip-Seq_BMDM_Mouse | 1.03387456 |
| 80 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 0.99437135 |
| 81 | VDR_24787735_ChIP-Seq_THP-1_Human | 0.98553691 |
| 82 | CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse | 0.96462719 |
| 83 | NCOR1_26117541_ChIP-Seq_K562_Human | 0.95316615 |
| 84 | GATA3_26560356_Chip-Seq_TH1_Human | 0.94430904 |
| 85 | PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 0.89929140 |
| 86 | Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse | 0.89765234 |
| 87 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 0.89567658 |
| 88 | CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 0.89463051 |
| 89 | RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.89152134 |
| 90 | PU.1_20513432_ChIP-Seq_Bcells_Mouse | 0.87500330 |
| 91 | KDM5A_27292631_Chip-Seq_BREAST_Human | 0.87463518 |
| 92 | GATA1_22383799_ChIP-Seq_G1ME_Mouse | 0.86779823 |
| 93 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 0.86069350 |
| 94 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 0.86022045 |
| 95 | BCL6_27268052_Chip-Seq_Bcells_Human | 0.85577084 |
| 96 | CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 0.85045220 |
| 97 | ELK1_19687146_ChIP-ChIP_HELA_Human | 0.84952794 |
| 98 | PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse | 0.84078401 |
| 99 | GATA1_19941826_ChIP-Seq_K562_Human | 0.83824128 |
| 100 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.82780591 |
| 101 | TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.81763961 |
| 102 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 0.81532825 |
| 103 | CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse | 0.79722513 |
| 104 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 0.78497826 |
| 105 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 0.77898761 |
| 106 | LMO2_20887958_ChIP-Seq_HPC-7_Mouse | 0.77567392 |
| 107 | RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.77524167 |
| 108 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 0.76530646 |
| 109 | SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human | 0.75898224 |
| 110 | SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 0.74296676 |
| 111 | NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human | 0.73808659 |
| 112 | KLF4_18264089_ChIP-ChIP_MESCs_Mouse | 0.73317621 |
| 113 | CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse | 0.72687247 |
| 114 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 0.72176113 |
| 115 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 0.70788435 |
| 116 | GATA2_20887958_ChIP-Seq_HPC-7_Mouse | 0.68601514 |
| 117 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 0.68570362 |
| 118 | LXR_22292898_ChIP-Seq_THP-1_Human | 0.68016380 |
| 119 | PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse | 0.67884111 |
| 120 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 0.67079151 |
| 121 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 0.66701387 |
| 122 | KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human | 0.66491331 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003763_abnormal_thymus_physiology | 6.36355301 |
| 2 | MP0000685_abnormal_immune_system | 3.87600532 |
| 3 | MP0005671_abnormal_response_to | 3.86446431 |
| 4 | MP0002166_altered_tumor_susceptibility | 3.29094027 |
| 5 | MP0000703_abnormal_thymus_morphology | 3.15187553 |
| 6 | MP0001800_abnormal_humoral_immune | 3.05283793 |
| 7 | MP0009333_abnormal_splenocyte_physiolog | 3.02345681 |
| 8 | MP0002398_abnormal_bone_marrow | 2.95231199 |
| 9 | MP0001835_abnormal_antigen_presentation | 2.86495253 |
| 10 | MP0005387_immune_system_phenotype | 2.78609742 |
| 11 | MP0001790_abnormal_immune_system | 2.78609742 |
| 12 | MP0002006_tumorigenesis | 2.72879897 |
| 13 | MP0002420_abnormal_adaptive_immunity | 2.69190344 |
| 14 | MP0005000_abnormal_immune_tolerance | 2.67421109 |
| 15 | MP0003300_gastrointestinal_ulcer | 2.65741571 |
| 16 | MP0002723_abnormal_immune_serum | 2.65655094 |
| 17 | MP0001819_abnormal_immune_cell | 2.64694966 |
| 18 | MP0002405_respiratory_system_inflammati | 2.55750016 |
| 19 | MP0002396_abnormal_hematopoietic_system | 2.52637274 |
| 20 | MP0003436_decreased_susceptibility_to | 2.47637118 |
| 21 | MP0002722_abnormal_immune_system | 2.46149722 |
| 22 | * MP0000716_abnormal_immune_system | 2.46044056 |
| 23 | MP0001873_stomach_inflammation | 2.42613936 |
| 24 | MP0002452_abnormal_antigen_presenting | 2.38197693 |
| 25 | MP0003866_abnormal_defecation | 2.33575475 |
| 26 | MP0000689_abnormal_spleen_morphology | 2.31266932 |
| 27 | MP0010155_abnormal_intestine_physiology | 2.19833250 |
| 28 | MP0009785_altered_susceptibility_to | 2.13102940 |
| 29 | MP0005025_abnormal_response_to | 2.12123958 |
| 30 | MP0004947_skin_inflammation | 2.09310208 |
| 31 | MP0003303_peritoneal_inflammation | 2.08563171 |
| 32 | * MP0002429_abnormal_blood_cell | 2.01280834 |
| 33 | MP0003724_increased_susceptibility_to | 2.00696589 |
| 34 | MP0004808_abnormal_hematopoietic_stem | 1.97498618 |
| 35 | MP0006082_CNS_inflammation | 1.93084743 |
| 36 | MP0004510_myositis | 1.85896574 |
| 37 | MP0002933_joint_inflammation | 1.83562491 |
| 38 | MP0002163_abnormal_gland_morphology | 1.80218162 |
| 39 | MP0002277_abnormal_respiratory_mucosa | 1.78632158 |
| 40 | MP0001853_heart_inflammation | 1.73489754 |
| 41 | MP0005464_abnormal_platelet_physiology | 1.69806639 |
| 42 | MP0000372_irregular_coat_pigmentation | 1.68136144 |
| 43 | MP0004381_abnormal_hair_follicle | 1.65184205 |
| 44 | MP0001845_abnormal_inflammatory_respons | 1.57631812 |
| 45 | MP0002148_abnormal_hypersensitivity_rea | 1.51893853 |
| 46 | MP0002419_abnormal_innate_immunity | 1.49091572 |
| 47 | MP0003011_delayed_dark_adaptation | 1.48405388 |
| 48 | MP0003172_abnormal_lysosome_physiology | 1.43246806 |
| 49 | MP0000465_gastrointestinal_hemorrhage | 1.40877219 |
| 50 | MP0005397_hematopoietic_system_phenotyp | 1.34084663 |
| 51 | MP0001545_abnormal_hematopoietic_system | 1.34084663 |
| 52 | MP0000858_altered_metastatic_potential | 1.33829207 |
| 53 | MP0002132_abnormal_respiratory_system | 1.29406361 |
| 54 | MP0005310_abnormal_salivary_gland | 1.29187078 |
| 55 | MP0008961_abnormal_basal_metabolism | 1.27679024 |
| 56 | MP0000490_abnormal_crypts_of | 1.26054039 |
| 57 | MP0003806_abnormal_nucleotide_metabolis | 1.24798626 |
| 58 | MP0009278_abnormal_bone_marrow | 1.24709282 |
| 59 | MP0008057_abnormal_DNA_replication | 1.24253543 |
| 60 | MP0010352_gastrointestinal_tract_polyps | 1.13820116 |
| 61 | MP0002019_abnormal_tumor_incidence | 1.11698721 |
| 62 | MP0005075_abnormal_melanosome_morpholog | 1.09532789 |
| 63 | MP0010094_abnormal_chromosome_stability | 1.03509498 |
| 64 | MP0002009_preneoplasia | 1.03082866 |
| 65 | MP0001533_abnormal_skeleton_physiology | 0.99854472 |
| 66 | MP0003077_abnormal_cell_cycle | 0.99267739 |
| 67 | MP0004957_abnormal_blastocyst_morpholog | 0.92576199 |
| 68 | MP0003448_altered_tumor_morphology | 0.92382590 |
| 69 | MP0002138_abnormal_hepatobiliary_system | 0.90060386 |
| 70 | MP0008469_abnormal_protein_level | 0.88150147 |
| 71 | MP0005379_endocrine/exocrine_gland_phen | 0.86771094 |
| 72 | MP0008260_abnormal_autophagy | 0.85522321 |
| 73 | MP0005023_abnormal_wound_healing | 0.83244376 |
| 74 | MP0003693_abnormal_embryo_hatching | 0.80931995 |
| 75 | MP0004883_abnormal_blood_vessel | 0.80760007 |
| 76 | MP0002998_abnormal_bone_remodeling | 0.80084756 |
| 77 | MP0001851_eye_inflammation | 0.79762723 |
| 78 | MP0005076_abnormal_cell_differentiation | 0.78674351 |
| 79 | MP0004185_abnormal_adipocyte_glucose | 0.74435050 |
| 80 | MP0009764_decreased_sensitivity_to | 0.72410744 |
| 81 | MP0001188_hyperpigmentation | 0.70805745 |
| 82 | MP0001919_abnormal_reproductive_system | 0.70743021 |
| 83 | MP0000015_abnormal_ear_pigmentation | 0.68544251 |
| 84 | MP0002693_abnormal_pancreas_physiology | 0.68386913 |
| 85 | MP0009765_abnormal_xenobiotic_induced | 0.67730470 |
| 86 | MP0000609_abnormal_liver_physiology | 0.65949116 |
| 87 | MP0005166_decreased_susceptibility_to | 0.65057836 |
| 88 | MP0003191_abnormal_cellular_cholesterol | 0.63691970 |
| 89 | MP0000350_abnormal_cell_proliferation | 0.63265836 |
| 90 | MP0000477_abnormal_intestine_morphology | 0.62944906 |
| 91 | MP0001243_abnormal_dermal_layer | 0.62192608 |
| 92 | MP0003183_abnormal_peptide_metabolism | 0.61236734 |
| 93 | MP0001348_abnormal_lacrimal_gland | 0.60912354 |
| 94 | MP0003786_premature_aging | 0.60363105 |
| 95 | MP0003828_pulmonary_edema | 0.59844406 |
| 96 | MP0003795_abnormal_bone_structure | 0.58922520 |
| 97 | MP0008007_abnormal_cellular_replicative | 0.58359879 |
| 98 | MP0005390_skeleton_phenotype | 0.57754396 |
| 99 | MP0004134_abnormal_chest_morphology | 0.57326930 |
| 100 | MP0003111_abnormal_nucleus_morphology | 0.57287903 |
| 101 | MP0004130_abnormal_muscle_cell | 0.54920034 |
| 102 | MP0001663_abnormal_digestive_system | 0.54809855 |
| 103 | MP0009763_increased_sensitivity_to | 0.54753502 |
| 104 | MP0005164_abnormal_response_to | 0.54692599 |
| 105 | MP0005174_abnormal_tail_pigmentation | 0.54535917 |
| 106 | MP0000313_abnormal_cell_death | 0.54524213 |
| 107 | MP0000604_amyloidosis | 0.50571923 |
| 108 | MP0001730_embryonic_growth_arrest | 0.50038615 |
| 109 | MP0003091_abnormal_cell_migration | 0.49817147 |
| 110 | MP0002822_catalepsy | 0.48645037 |
| 111 | MP0008874_decreased_physiological_sensi | 0.48153732 |
| 112 | MP0003656_abnormal_erythrocyte_physiolo | 0.47595105 |
| 113 | MP0000249_abnormal_blood_vessel | 0.45709605 |
| 114 | MP0001216_abnormal_epidermal_layer | 0.44774785 |
| 115 | MP0008058_abnormal_DNA_repair | 0.42807828 |
| 116 | MP0001986_abnormal_taste_sensitivity | 0.41663485 |
| 117 | MP0001191_abnormal_skin_condition | 0.41520474 |
| 118 | MP0003453_abnormal_keratinocyte_physiol | 0.41350304 |
| 119 | MP0000920_abnormal_myelination | 0.41311187 |
| 120 | MP0002083_premature_death | 0.40985698 |
| 121 | MP0000367_abnormal_coat/_hair | 0.40656298 |
| 122 | MP0002136_abnormal_kidney_physiology | 0.40488518 |
| 123 | MP0008770_decreased_survivor_rate | 0.39104908 |
| 124 | MP0008569_lethality_at_weaning | 0.38723042 |
| 125 | MP0003045_fibrosis | 0.38231418 |
| 126 | MP0008873_increased_physiological_sensi | 0.38115966 |
| 127 | MP0002095_abnormal_skin_pigmentation | 0.37709320 |
| 128 | MP0003959_abnormal_lean_body | 0.37336881 |
| 129 | MP0002086_abnormal_extraembryonic_tissu | 0.37053249 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | T lymphocytopenia (HP:0005403) | 8.88760098 |
| 2 | Abnormality of T cell number (HP:0011839) | 8.46065698 |
| 3 | Severe combined immunodeficiency (HP:0004430) | 6.08578616 |
| 4 | Panhypogammaglobulinemia (HP:0003139) | 5.83438591 |
| 5 | Abnormality of T cells (HP:0002843) | 5.82247813 |
| 6 | Combined immunodeficiency (HP:0005387) | 5.81281382 |
| 7 | Elevated erythrocyte sedimentation rate (HP:0003565) | 5.56200028 |
| 8 | Stomatitis (HP:0010280) | 5.43605547 |
| 9 | Recurrent viral infections (HP:0004429) | 5.20518205 |
| 10 | Chronic otitis media (HP:0000389) | 4.79479016 |
| 11 | Abnormality of B cell number (HP:0010975) | 4.77205689 |
| 12 | B lymphocytopenia (HP:0010976) | 4.77205689 |
| 13 | Recurrent fungal infections (HP:0002841) | 4.70968126 |
| 14 | Nasal polyposis (HP:0100582) | 4.68990571 |
| 15 | Eosinophilia (HP:0001880) | 4.54353568 |
| 16 | Recurrent bronchitis (HP:0002837) | 4.40099080 |
| 17 | IgG deficiency (HP:0004315) | 4.38596394 |
| 18 | Orchitis (HP:0100796) | 4.30547985 |
| 19 | Abnormality of the fingertips (HP:0001211) | 4.18207905 |
| 20 | Abnormality of eosinophils (HP:0001879) | 4.10964342 |
| 21 | Abnormal delayed hypersensitivity skin test (HP:0002963) | 4.09939907 |
| 22 | Recurrent bacterial skin infections (HP:0005406) | 4.04153399 |
| 23 | Granulocytopenia (HP:0001913) | 3.91712200 |
| 24 | Recurrent abscess formation (HP:0002722) | 3.91135796 |
| 25 | Dysautonomia (HP:0002459) | 3.90933821 |
| 26 | Abnormality of the nasal mucosa (HP:0000433) | 3.89060816 |
| 27 | Thyroiditis (HP:0100646) | 3.79747981 |
| 28 | IgM deficiency (HP:0002850) | 3.76744062 |
| 29 | Pustule (HP:0200039) | 3.69258731 |
| 30 | Abnormality of macrophages (HP:0004311) | 3.49129735 |
| 31 | Leukocytosis (HP:0001974) | 3.47458786 |
| 32 | Recurrent cutaneous fungal infections (HP:0011370) | 3.39207159 |
| 33 | Chronic mucocutaneous candidiasis (HP:0002728) | 3.39207159 |
| 34 | Hypoplasia of the thymus (HP:0000778) | 3.34677308 |
| 35 | Eczematoid dermatitis (HP:0000976) | 3.33293117 |
| 36 | Abnormality of T cell physiology (HP:0011840) | 3.27620705 |
| 37 | Keratoconjunctivitis sicca (HP:0001097) | 3.23914713 |
| 38 | Autoimmune hemolytic anemia (HP:0001890) | 3.18834820 |
| 39 | Basal cell carcinoma (HP:0002671) | 3.15272238 |
| 40 | Autoimmune thrombocytopenia (HP:0001973) | 3.15161377 |
| 41 | Joint swelling (HP:0001386) | 3.11428139 |
| 42 | Chronic diarrhea (HP:0002028) | 3.00530541 |
| 43 | Keratoconjunctivitis (HP:0001096) | 2.98679302 |
| 44 | Lymphopenia (HP:0001888) | 2.98274833 |
| 45 | Spontaneous hematomas (HP:0007420) | 2.93845727 |
| 46 | Abnormality of cells of the lymphoid lineage (HP:0012140) | 2.92398166 |
| 47 | Increased IgM level (HP:0003496) | 2.91436823 |
| 48 | Myositis (HP:0100614) | 2.83375001 |
| 49 | Lymphoma (HP:0002665) | 2.82759892 |
| 50 | Abnormal platelet volume (HP:0011876) | 2.82460292 |
| 51 | Alveolar cell carcinoma (HP:0006519) | 2.81160014 |
| 52 | Thrombocytosis (HP:0001894) | 2.74405801 |
| 53 | Hypochromic anemia (HP:0001931) | 2.72519469 |
| 54 | Gangrene (HP:0100758) | 2.68887874 |
| 55 | Increased IgE level (HP:0003212) | 2.67340720 |
| 56 | Anhidrosis (HP:0000970) | 2.64438088 |
| 57 | Meningitis (HP:0001287) | 2.63465910 |
| 58 | Recurrent gram-negative bacterial infections (HP:0005420) | 2.62734394 |
| 59 | IgA deficiency (HP:0002720) | 2.62136150 |
| 60 | Abnormality of the pleura (HP:0002103) | 2.59666193 |
| 61 | Neoplasm of the tracheobronchial system (HP:0100552) | 2.59459982 |
| 62 | Slow saccadic eye movements (HP:0000514) | 2.58689945 |
| 63 | Prolonged bleeding time (HP:0003010) | 2.55377285 |
| 64 | Gingivitis (HP:0000230) | 2.54159697 |
| 65 | Episodic fever (HP:0001954) | 2.54112298 |
| 66 | Orthostatic hypotension (HP:0001278) | 2.51810047 |
| 67 | Abnormality of cells of the erythroid lineage (HP:0012130) | 2.51656066 |
| 68 | Bronchitis (HP:0012387) | 2.51518510 |
| 69 | Gastrointestinal infarctions (HP:0005244) | 2.49328499 |
| 70 | Verrucae (HP:0200043) | 2.47650260 |
| 71 | Papilloma (HP:0012740) | 2.47650260 |
| 72 | Gastrointestinal inflammation (HP:0004386) | 2.47505903 |
| 73 | Inflammation of the large intestine (HP:0002037) | 2.46592570 |
| 74 | Chronic sinusitis (HP:0011109) | 2.42274756 |
| 75 | Abnormal number of erythroid precursors (HP:0012131) | 2.38026749 |
| 76 | Increased mean platelet volume (HP:0011877) | 2.36122007 |
| 77 | Hypochromic microcytic anemia (HP:0004840) | 2.35428704 |
| 78 | Hemoptysis (HP:0002105) | 2.34201472 |
| 79 | Keratitis (HP:0000491) | 2.33829842 |
| 80 | Encephalitis (HP:0002383) | 2.32300215 |
| 81 | Hypergammaglobulinemia (HP:0010702) | 2.31892724 |
| 82 | Oral leukoplakia (HP:0002745) | 2.31474769 |
| 83 | Papilledema (HP:0001085) | 2.30859182 |
| 84 | Arthropathy (HP:0003040) | 2.29485485 |
| 85 | Epistaxis (HP:0000421) | 2.29109276 |
| 86 | Urticaria (HP:0001025) | 2.28976384 |
| 87 | Glomerulopathy (HP:0100820) | 2.27541491 |
| 88 | Microcytic anemia (HP:0001935) | 2.27148602 |
| 89 | Vasculitis (HP:0002633) | 2.25921079 |
| 90 | Increased density of long bones (HP:0006392) | 2.24615178 |
| 91 | Aplasia/Hypoplasia of the thymus (HP:0010515) | 2.16768691 |
| 92 | Abnormality of the pericardium (HP:0001697) | 2.15148723 |
| 93 | Chest pain (HP:0100749) | 2.14749799 |
| 94 | Anorexia (HP:0002039) | 2.12248079 |
| 95 | Mediastinal lymphadenopathy (HP:0100721) | 2.08892548 |
| 96 | Aplastic anemia (HP:0001915) | 2.08130045 |
| 97 | Pulmonary fibrosis (HP:0002206) | 2.06319155 |
| 98 | Recurrent sinusitis (HP:0011108) | 2.03915711 |
| 99 | Polyneuropathy (HP:0001271) | 2.03174482 |
| 100 | Bicuspid aortic valve (HP:0001647) | 2.02324885 |
| 101 | Abnormal autonomic nervous system physiology (HP:0012332) | 2.02184549 |
| 102 | Ureteral stenosis (HP:0000071) | 2.00890685 |
| 103 | Chronic obstructive pulmonary disease (HP:0006510) | 1.99715671 |
| 104 | Obstructive lung disease (HP:0006536) | 1.99715671 |
| 105 | Restrictive lung disease (HP:0002091) | 1.98591632 |
| 106 | Gingival bleeding (HP:0000225) | 1.93359914 |
| 107 | Severe visual impairment (HP:0001141) | 1.92710120 |
| 108 | Persistence of primary teeth (HP:0006335) | 1.92537031 |
| 109 | Amaurosis fugax (HP:0100576) | 1.92023547 |
| 110 | Pulmonary infiltrates (HP:0002113) | 1.91451160 |
| 111 | Bronchiectasis (HP:0002110) | 1.90900297 |
| 112 | Recurrent skin infections (HP:0001581) | 1.90365166 |
| 113 | Cheilitis (HP:0100825) | 1.89851281 |
| 114 | Hepatitis (HP:0012115) | 1.89552421 |
| 115 | Premature loss of primary teeth (HP:0006323) | 1.86853859 |
| 116 | Abnormality of the prostate (HP:0008775) | 1.85745461 |
| 117 | Recurrent otitis media (HP:0000403) | 1.85177449 |
| 118 | Agammaglobulinemia (HP:0004432) | 1.82017345 |
| 119 | Pulmonary embolism (HP:0002204) | 1.81687943 |
| 120 | Fatigue (HP:0012378) | 1.81510217 |
| 121 | Ureteral obstruction (HP:0006000) | 1.78829111 |
| 122 | Poikiloderma (HP:0001029) | 1.78578028 |
| 123 | Cellular immunodeficiency (HP:0005374) | 1.77326873 |
| 124 | Retrobulbar optic neuritis (HP:0100654) | 1.75227362 |
| 125 | Optic neuritis (HP:0100653) | 1.75227362 |
| 126 | Abnormality of the thymus (HP:0000777) | 1.74291839 |
| 127 | Petechiae (HP:0000967) | 1.74275022 |
| 128 | Arterial thrombosis (HP:0004420) | 1.72747510 |
| 129 | Frequent falls (HP:0002359) | 1.71998852 |
| 130 | Reticulocytopenia (HP:0001896) | 1.71741309 |
| 131 | Purpura (HP:0000979) | 1.70457930 |
| 132 | Macrocytic anemia (HP:0001972) | 1.70268003 |
| 133 | Emphysema (HP:0002097) | 1.68912429 |
| 134 | Hypoproteinemia (HP:0003075) | 1.68390197 |
| 135 | Prominent nose (HP:0000448) | 1.62308111 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | TXK | 5.95336171 |
| 2 | MAP4K1 | 5.87730382 |
| 3 | ITK | 3.42187213 |
| 4 | RIPK4 | 3.41712118 |
| 5 | ZAP70 | 3.34461666 |
| 6 | JAK3 | 3.05245619 |
| 7 | FGFR4 | 2.87365278 |
| 8 | TAOK3 | 2.56738011 |
| 9 | STK10 | 2.56328061 |
| 10 | GRK6 | 2.54304834 |
| 11 | CAMKK2 | 2.52418272 |
| 12 | EEF2K | 2.50133805 |
| 13 | TYK2 | 2.39685346 |
| 14 | NLK | 2.38855141 |
| 15 | IKBKE | 2.20668371 |
| 16 | MAP3K10 | 2.11794880 |
| 17 | FGFR3 | 1.91767257 |
| 18 | PKN2 | 1.87995659 |
| 19 | TEC | 1.83922518 |
| 20 | CAMKK1 | 1.79997945 |
| 21 | LCK | 1.78453201 |
| 22 | MATK | 1.76872272 |
| 23 | PRPF4B | 1.74903689 |
| 24 | NME2 | 1.69352712 |
| 25 | MAP3K14 | 1.68568350 |
| 26 | MST4 | 1.63519462 |
| 27 | JAK1 | 1.54270506 |
| 28 | CSK | 1.50250623 |
| 29 | PRKCH | 1.43423878 |
| 30 | SYK | 1.40657336 |
| 31 | BTK | 1.39029248 |
| 32 | HCK | 1.37758045 |
| 33 | MAP3K13 | 1.34494432 |
| 34 | RPS6KA4 | 1.27216106 |
| 35 | LRRK2 | 1.26819600 |
| 36 | CDK12 | 1.24062208 |
| 37 | PRKCQ | 1.20934853 |
| 38 | TRIB3 | 1.19232858 |
| 39 | TBK1 | 1.11588534 |
| 40 | MAP3K7 | 1.08774577 |
| 41 | TYRO3 | 1.04329831 |
| 42 | CLK1 | 1.03729032 |
| 43 | PASK | 1.03275480 |
| 44 | IKBKB | 1.02268743 |
| 45 | NTRK1 | 1.02253061 |
| 46 | JAK2 | 1.01273064 |
| 47 | MARK3 | 1.00030808 |
| 48 | PIM1 | 0.99569647 |
| 49 | MAP3K9 | 0.90280545 |
| 50 | SIK2 | 0.89899028 |
| 51 | BLK | 0.88785716 |
| 52 | TAOK1 | 0.87811669 |
| 53 | ERN1 | 0.86098921 |
| 54 | CHUK | 0.83825275 |
| 55 | EPHB1 | 0.83462589 |
| 56 | PDGFRB | 0.80226492 |
| 57 | MAP3K3 | 0.74997904 |
| 58 | KSR2 | 0.74165116 |
| 59 | BMPR2 | 0.74128165 |
| 60 | MAP2K3 | 0.73374127 |
| 61 | CDK4 | 0.72006599 |
| 62 | ALK | 0.71735655 |
| 63 | FES | 0.71540456 |
| 64 | HIPK2 | 0.67393961 |
| 65 | TNK2 | 0.66470054 |
| 66 | MAP3K1 | 0.65769035 |
| 67 | STK24 | 0.64852697 |
| 68 | ARAF | 0.63812641 |
| 69 | CDC7 | 0.63472295 |
| 70 | RPS6KB2 | 0.62926769 |
| 71 | MARK2 | 0.62360488 |
| 72 | DYRK1B | 0.61390760 |
| 73 | TESK2 | 0.60623893 |
| 74 | EPHA3 | 0.59384471 |
| 75 | MOS | 0.59144048 |
| 76 | BRD4 | 0.59071637 |
| 77 | FGFR2 | 0.58736663 |
| 78 | MELK | 0.58114832 |
| 79 | MAP3K12 | 0.57548209 |
| 80 | YES1 | 0.57119743 |
| 81 | LYN | 0.56720710 |
| 82 | TGFBR1 | 0.55799256 |
| 83 | KIT | 0.55000359 |
| 84 | MAPK7 | 0.54772896 |
| 85 | FLT3 | 0.54418766 |
| 86 | PDK1 | 0.53722259 |
| 87 | STK11 | 0.52856343 |
| 88 | TGFBR2 | 0.51763453 |
| 89 | PTK6 | 0.51431851 |
| 90 | STK4 | 0.50711288 |
| 91 | KDR | 0.50372916 |
| 92 | FGFR1 | 0.50347607 |
| 93 | GRK7 | 0.47317836 |
| 94 | TSSK6 | 0.46112964 |
| 95 | PIK3CG | 0.45872007 |
| 96 | PRKD2 | 0.45851777 |
| 97 | IRAK4 | 0.45191015 |
| 98 | FGR | 0.44908982 |
| 99 | MAP2K6 | 0.41669752 |
| 100 | INSR | 0.40911992 |
| 101 | NEK2 | 0.40199715 |
| 102 | MAP3K8 | 0.40134966 |
| 103 | MAPKAPK2 | 0.38899150 |
| 104 | SCYL2 | 0.38163221 |
| 105 | RPS6KA5 | 0.38003877 |
| 106 | MAP2K2 | 0.37393942 |
| 107 | TTN | 0.36979197 |
| 108 | MAPK12 | 0.36623572 |
| 109 | CDK6 | 0.36597002 |
| 110 | CSF1R | 0.36465304 |
| 111 | TAOK2 | 0.35748061 |
| 112 | MAPK11 | 0.33927685 |
| 113 | NTRK2 | 0.33297169 |
| 114 | SIK3 | 0.32979939 |
| 115 | CDK9 | 0.32598183 |
| 116 | MAPK4 | 0.32338923 |
| 117 | CAMK1 | 0.32089360 |
| 118 | STK38 | 0.30386197 |
| 119 | FYN | 0.30205391 |
| 120 | RAF1 | 0.30062618 |
| 121 | SGK3 | 0.28744295 |
| 122 | MAP3K2 | 0.28650173 |
| 123 | NEK6 | 0.28570433 |
| 124 | EIF2AK3 | 0.27179840 |
| 125 | RPS6KA6 | 0.25783102 |
| 126 | MAPK3 | 0.25443420 |
| 127 | CHEK1 | 0.25378055 |
| 128 | CAMK4 | 0.25234138 |
| 129 | SIK1 | 0.25117480 |
| 130 | MAP3K11 | 0.24474343 |
| 131 | EGFR | 0.24396923 |
| 132 | IGF1R | 0.19360052 |
| 133 | IRAK1 | 0.19359408 |
| 134 | RET | 0.19296717 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Primary immunodeficiency_Homo sapiens_hsa05340 | 5.86846219 |
| 2 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 4.41845608 |
| 3 | Measles_Homo sapiens_hsa05162 | 2.74820077 |
| 4 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 2.72749460 |
| 5 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 2.64553636 |
| 6 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 2.56632390 |
| 7 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 2.50802135 |
| 8 | Allograft rejection_Homo sapiens_hsa05330 | 2.10349714 |
| 9 | Antigen processing and presentation_Homo sapiens_hsa04612 | 2.09289191 |
| 10 | Ribosome_Homo sapiens_hsa03010 | 2.06488631 |
| 11 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 1.97609894 |
| 12 | Osteoclast differentiation_Homo sapiens_hsa04380 | 1.90840708 |
| 13 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 1.85838491 |
| 14 | Graft-versus-host disease_Homo sapiens_hsa05332 | 1.76409023 |
| 15 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 1.73148809 |
| 16 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 1.69544346 |
| 17 | Leishmaniasis_Homo sapiens_hsa05140 | 1.66277394 |
| 18 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 1.66272003 |
| 19 | Herpes simplex infection_Homo sapiens_hsa05168 | 1.62515348 |
| 20 | Viral myocarditis_Homo sapiens_hsa05416 | 1.61451574 |
| 21 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 1.53317030 |
| 22 | Regulation of autophagy_Homo sapiens_hsa04140 | 1.51442008 |
| 23 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.50252667 |
| 24 | Hepatitis B_Homo sapiens_hsa05161 | 1.42110505 |
| 25 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 1.38053184 |
| 26 | Toxoplasmosis_Homo sapiens_hsa05145 | 1.34304793 |
| 27 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 1.33619381 |
| 28 | HTLV-I infection_Homo sapiens_hsa05166 | 1.32449185 |
| 29 | Colorectal cancer_Homo sapiens_hsa05210 | 1.30329416 |
| 30 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 1.29388719 |
| 31 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 1.27716817 |
| 32 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 1.26728755 |
| 33 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 1.22115787 |
| 34 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 1.21175915 |
| 35 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 1.18046439 |
| 36 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.17815983 |
| 37 | Pancreatic cancer_Homo sapiens_hsa05212 | 1.14322617 |
| 38 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 1.13206647 |
| 39 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 1.11532854 |
| 40 | Proteasome_Homo sapiens_hsa03050 | 1.11401596 |
| 41 | Spliceosome_Homo sapiens_hsa03040 | 1.08822987 |
| 42 | Thyroid cancer_Homo sapiens_hsa05216 | 1.06536801 |
| 43 | Influenza A_Homo sapiens_hsa05164 | 1.05912941 |
| 44 | TNF signaling pathway_Homo sapiens_hsa04668 | 1.05706339 |
| 45 | Shigellosis_Homo sapiens_hsa05131 | 1.05497755 |
| 46 | African trypanosomiasis_Homo sapiens_hsa05143 | 1.04711993 |
| 47 | DNA replication_Homo sapiens_hsa03030 | 1.04511026 |
| 48 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 1.03910186 |
| 49 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 1.02014515 |
| 50 | Asthma_Homo sapiens_hsa05310 | 1.01085551 |
| 51 | Platelet activation_Homo sapiens_hsa04611 | 0.97833935 |
| 52 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.93079151 |
| 53 | Apoptosis_Homo sapiens_hsa04210 | 0.92688912 |
| 54 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.90915977 |
| 55 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 0.88365233 |
| 56 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.84881774 |
| 57 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.84333505 |
| 58 | Base excision repair_Homo sapiens_hsa03410 | 0.82083121 |
| 59 | Hepatitis C_Homo sapiens_hsa05160 | 0.81435423 |
| 60 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.79942526 |
| 61 | Endometrial cancer_Homo sapiens_hsa05213 | 0.79467654 |
| 62 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.79456972 |
| 63 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.74755487 |
| 64 | Mismatch repair_Homo sapiens_hsa03430 | 0.74115258 |
| 65 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.73281627 |
| 66 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.72076864 |
| 67 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.71508632 |
| 68 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.71082952 |
| 69 | Legionellosis_Homo sapiens_hsa05134 | 0.70775064 |
| 70 | Prostate cancer_Homo sapiens_hsa05215 | 0.68618399 |
| 71 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 0.64804477 |
| 72 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.64629232 |
| 73 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.63551216 |
| 74 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.63388476 |
| 75 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.63324730 |
| 76 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.57458888 |
| 77 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.57127818 |
| 78 | Phagosome_Homo sapiens_hsa04145 | 0.55605306 |
| 79 | RNA transport_Homo sapiens_hsa03013 | 0.54569852 |
| 80 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.52552947 |
| 81 | RNA degradation_Homo sapiens_hsa03018 | 0.52351490 |
| 82 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.51404469 |
| 83 | Tuberculosis_Homo sapiens_hsa05152 | 0.51312965 |
| 84 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.48494536 |
| 85 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 0.48045425 |
| 86 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.47954698 |
| 87 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.47890611 |
| 88 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.47165123 |
| 89 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.44857810 |
| 90 | Insulin resistance_Homo sapiens_hsa04931 | 0.43424045 |
| 91 | Protein export_Homo sapiens_hsa03060 | 0.42957016 |
| 92 | Salmonella infection_Homo sapiens_hsa05132 | 0.42901128 |
| 93 | Pertussis_Homo sapiens_hsa05133 | 0.42437284 |
| 94 | Prion diseases_Homo sapiens_hsa05020 | 0.42307680 |
| 95 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.41682449 |
| 96 | One carbon pool by folate_Homo sapiens_hsa00670 | 0.40117148 |
| 97 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.39572945 |
| 98 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.38516916 |
| 99 | Lysine degradation_Homo sapiens_hsa00310 | 0.37200047 |
| 100 | Long-term potentiation_Homo sapiens_hsa04720 | 0.37055100 |
| 101 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.36846407 |
| 102 | Cell cycle_Homo sapiens_hsa04110 | 0.36549317 |
| 103 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.36110292 |
| 104 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.35814252 |
| 105 | Pathways in cancer_Homo sapiens_hsa05200 | 0.35791852 |
| 106 | Endocytosis_Homo sapiens_hsa04144 | 0.35759590 |
| 107 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.35665298 |
| 108 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.34569516 |
| 109 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.33842728 |
| 110 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.33278150 |
| 111 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.33006802 |
| 112 | Malaria_Homo sapiens_hsa05144 | 0.32485117 |
| 113 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.32150767 |
| 114 | Other glycan degradation_Homo sapiens_hsa00511 | 0.32077428 |
| 115 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.30357429 |
| 116 | Adherens junction_Homo sapiens_hsa04520 | 0.28927307 |
| 117 | Cholinergic synapse_Homo sapiens_hsa04725 | 0.28054237 |
| 118 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.26102332 |
| 119 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.25840099 |
| 120 | Morphine addiction_Homo sapiens_hsa05032 | 0.20535162 |
| 121 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.20225592 |
| 122 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.19463554 |
| 123 | Glioma_Homo sapiens_hsa05214 | 0.18883029 |
| 124 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.16274437 |

