

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | negative T cell selection (GO:0043383) | 8.72096873 |
| 2 | negative thymic T cell selection (GO:0045060) | 8.07359679 |
| 3 | positive regulation of gamma-delta T cell activation (GO:0046645) | 7.99257047 |
| 4 | DNA synthesis involved in DNA repair (GO:0000731) | 7.51474853 |
| 5 | positive T cell selection (GO:0043368) | 7.44739382 |
| 6 | regulation of gamma-delta T cell differentiation (GO:0045586) | 7.39815335 |
| 7 | negative regulation of leukocyte mediated cytotoxicity (GO:0001911) | 7.23002136 |
| 8 | negative regulation of cell killing (GO:0031342) | 7.23002136 |
| 9 | positive thymic T cell selection (GO:0045059) | 7.04953870 |
| 10 | positive regulation of interleukin-2 biosynthetic process (GO:0045086) | 7.04422761 |
| 11 | T cell selection (GO:0045058) | 6.96382962 |
| 12 | thymic T cell selection (GO:0045061) | 6.93806154 |
| 13 | antigen processing and presentation of endogenous peptide antigen (GO:0002483) | 6.72373225 |
| 14 | antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885) | 6.72373225 |
| 15 | positive regulation of antigen receptor-mediated signaling pathway (GO:0050857) | 6.72320134 |
| 16 | regulation of gamma-delta T cell activation (GO:0046643) | 6.59592906 |
| 17 | T cell receptor signaling pathway (GO:0050852) | 5.88980218 |
| 18 | response to interleukin-15 (GO:0070672) | 5.77626556 |
| 19 | regulation of isotype switching to IgG isotypes (GO:0048302) | 5.69902385 |
| 20 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G | 5.68264372 |
| 21 | positive regulation of B cell differentiation (GO:0045579) | 5.53778152 |
| 22 | antigen processing and presentation of endogenous antigen (GO:0019883) | 5.52458505 |
| 23 | regulation of T cell tolerance induction (GO:0002664) | 5.50591187 |
| 24 | interferon-gamma production (GO:0032609) | 5.41522001 |
| 25 | cellular response to interleukin-15 (GO:0071350) | 5.41096944 |
| 26 | T cell costimulation (GO:0031295) | 5.23887000 |
| 27 | lymphocyte costimulation (GO:0031294) | 5.14501934 |
| 28 | V(D)J recombination (GO:0033151) | 5.10798025 |
| 29 | leukocyte aggregation (GO:0070486) | 5.04329307 |
| 30 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 4.97247778 |
| 31 | regulation of interleukin-2 biosynthetic process (GO:0045076) | 4.96851953 |
| 32 | positive regulation of interleukin-2 production (GO:0032743) | 4.75801587 |
| 33 | antigen receptor-mediated signaling pathway (GO:0050851) | 4.69477503 |
| 34 | positive regulation of lamellipodium assembly (GO:0010592) | 4.62601157 |
| 35 | regulation of B cell differentiation (GO:0045577) | 4.61143167 |
| 36 | activated T cell proliferation (GO:0050798) | 4.59767090 |
| 37 | regulation of T cell receptor signaling pathway (GO:0050856) | 4.58919950 |
| 38 | positive regulation of tolerance induction (GO:0002645) | 4.55714160 |
| 39 | immunoglobulin mediated immune response (GO:0016064) | 4.44412215 |
| 40 | positive regulation of T cell differentiation in thymus (GO:0033089) | 4.43423284 |
| 41 | regulation of alpha-beta T cell proliferation (GO:0046640) | 4.42526979 |
| 42 | DNA deamination (GO:0045006) | 4.34038505 |
| 43 | synaptonemal complex assembly (GO:0007130) | 4.30813464 |
| 44 | regulation of antigen receptor-mediated signaling pathway (GO:0050854) | 4.28788198 |
| 45 | T cell migration (GO:0072678) | 4.26617968 |
| 46 | mast cell activation (GO:0045576) | 4.17231811 |
| 47 | positive regulation of alpha-beta T cell proliferation (GO:0046641) | 4.13537512 |
| 48 | regulation of interleukin-12 biosynthetic process (GO:0045075) | 4.10369643 |
| 49 | negative regulation of immunoglobulin mediated immune response (GO:0002890) | 4.02073871 |
| 50 | negative regulation of B cell mediated immunity (GO:0002713) | 4.02073871 |
| 51 | regulation of regulatory T cell differentiation (GO:0045589) | 4.00864821 |
| 52 | negative regulation of T cell apoptotic process (GO:0070233) | 3.96788976 |
| 53 | regulation of tolerance induction (GO:0002643) | 3.93992745 |
| 54 | regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923) | 3.91165196 |
| 55 | negative regulation of T cell mediated immunity (GO:0002710) | 3.87980240 |
| 56 | ribosomal small subunit assembly (GO:0000028) | 3.87785321 |
| 57 | T cell differentiation (GO:0030217) | 3.85966774 |
| 58 | cytidine metabolic process (GO:0046087) | 3.84917112 |
| 59 | cytidine catabolic process (GO:0006216) | 3.84917112 |
| 60 | cytidine deamination (GO:0009972) | 3.84917112 |
| 61 | viral transcription (GO:0019083) | 3.84434547 |
| 62 | alpha-beta T cell differentiation (GO:0046632) | 3.80763608 |
| 63 | positive regulation of granulocyte differentiation (GO:0030854) | 3.77578222 |
| 64 | synaptonemal complex organization (GO:0070193) | 3.76217453 |
| 65 | regulation of helicase activity (GO:0051095) | 3.74737817 |
| 66 | positive regulation of natural killer cell mediated immunity (GO:0002717) | 3.73730067 |
| 67 | positive regulation of natural killer cell mediated cytotoxicity (GO:0045954) | 3.73730067 |
| 68 | alpha-beta T cell activation (GO:0046631) | 3.73134545 |
| 69 | regulation of natural killer cell mediated cytotoxicity (GO:0042269) | 3.70372299 |
| 70 | regulation of natural killer cell mediated immunity (GO:0002715) | 3.70372299 |
| 71 | positive regulation of isotype switching (GO:0045830) | 3.69076561 |
| 72 | B cell receptor signaling pathway (GO:0050853) | 3.65918548 |
| 73 | translational termination (GO:0006415) | 3.65775615 |
| 74 | regulation of B cell receptor signaling pathway (GO:0050855) | 3.62586821 |
| 75 | B cell mediated immunity (GO:0019724) | 3.61234838 |
| 76 | cellular response to interleukin-4 (GO:0071353) | 3.60006397 |
| 77 | regulation of defense response to virus by virus (GO:0050690) | 3.54576229 |
| 78 | pyrimidine ribonucleoside catabolic process (GO:0046133) | 3.52694240 |
| 79 | negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665) | 3.50600562 |
| 80 | positive regulation of lamellipodium organization (GO:1902745) | 3.47098412 |
| 81 | regulation of interleukin-2 production (GO:0032663) | 3.45043152 |
| 82 | positive regulation of humoral immune response (GO:0002922) | 3.44177192 |
| 83 | negative regulation of T cell receptor signaling pathway (GO:0050860) | 3.42772793 |
| 84 | T cell activation (GO:0042110) | 3.40837225 |
| 85 | regulation of isotype switching (GO:0045191) | 3.39099252 |
| 86 | ribosomal small subunit biogenesis (GO:0042274) | 3.38429051 |
| 87 | mast cell degranulation (GO:0043303) | 3.38094761 |
| 88 | mast cell activation involved in immune response (GO:0002279) | 3.38094761 |
| 89 | regulation of respiratory burst (GO:0060263) | 3.32775961 |
| 90 | tolerance induction (GO:0002507) | 3.31226019 |
| 91 | positive regulation of B cell mediated immunity (GO:0002714) | 3.30406221 |
| 92 | positive regulation of immunoglobulin mediated immune response (GO:0002891) | 3.30406221 |
| 93 | Arp2/3 complex-mediated actin nucleation (GO:0034314) | 3.30036688 |
| 94 | response to interleukin-4 (GO:0070670) | 3.27980420 |
| 95 | regulation of hydrogen peroxide metabolic process (GO:0010310) | 3.25904029 |
| 96 | T cell homeostasis (GO:0043029) | 3.25396915 |
| 97 | regulation of interleukin-4 production (GO:0032673) | 3.24084404 |
| 98 | immune response-activating cell surface receptor signaling pathway (GO:0002429) | 3.22631207 |
| 99 | regulation of response to interferon-gamma (GO:0060330) | 3.18491187 |
| 100 | negative regulation of antigen receptor-mediated signaling pathway (GO:0050858) | 3.18039761 |
| 101 | regulation of chronic inflammatory response (GO:0002676) | 3.17702762 |
| 102 | G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589) | 3.16033862 |
| 103 | regulation of interferon-gamma-mediated signaling pathway (GO:0060334) | 3.13931708 |
| 104 | translational elongation (GO:0006414) | 3.13560314 |
| 105 | negative regulation of lymphocyte mediated immunity (GO:0002707) | 3.11863857 |
| 106 | antigen processing and presentation via MHC class Ib (GO:0002475) | 3.11216104 |
| 107 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 3.10807147 |
| 108 | positive regulation of T cell activation (GO:0050870) | 3.10117237 |
| 109 | negative regulation of leukocyte mediated immunity (GO:0002704) | 3.09663110 |
| 110 | positive regulation of DNA recombination (GO:0045911) | 3.09346222 |
| 111 | regulation of immunoglobulin mediated immune response (GO:0002889) | 3.09112572 |
| 112 | regulation of immunoglobulin production (GO:0002637) | 3.06358835 |
| 113 | regulation of T cell apoptotic process (GO:0070232) | 3.04995042 |
| 114 | negative regulation of thymocyte apoptotic process (GO:0070244) | 3.04718437 |
| 115 | maturation of SSU-rRNA (GO:0030490) | 3.04362850 |
| 116 | positive regulation of interleukin-4 production (GO:0032753) | 3.02472311 |
| 117 | negative regulation of interleukin-12 production (GO:0032695) | 3.02168405 |
| 118 | positive regulation of inflammatory response to antigenic stimulus (GO:0002863) | 3.01068931 |
| 119 | negative regulation of phagocytosis (GO:0050765) | 3.00073378 |
| 120 | regulation of B cell mediated immunity (GO:0002712) | 3.00056415 |
| 121 | regulation of leukocyte mediated cytotoxicity (GO:0001910) | 2.98376015 |
| 122 | T cell proliferation (GO:0042098) | 2.98370061 |
| 123 | negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class | 2.97349803 |
| 124 | positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372) | 2.96145348 |
| 125 | negative regulation of peptidyl-lysine acetylation (GO:2000757) | 2.95314295 |
| 126 | positive regulation of immunoglobulin production (GO:0002639) | 2.94997563 |
| 127 | Peyers patch development (GO:0048541) | 2.93833819 |
| 128 | mucosal-associated lymphoid tissue development (GO:0048537) | 2.93833819 |
| 129 | negative regulation of erythrocyte differentiation (GO:0045647) | 2.93830740 |
| 130 | positive regulation of leukocyte mediated cytotoxicity (GO:0001912) | 2.93232042 |
| 131 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 2.92157051 |
| 132 | leukocyte cell-cell adhesion (GO:0007159) | 2.91445886 |
| 133 | somatic cell DNA recombination (GO:0016444) | 2.91314353 |
| 134 | somatic diversification of immune receptors via germline recombination within a single locus (GO:000 | 2.91314353 |
| 135 | NIK/NF-kappaB signaling (GO:0038061) | 2.90486450 |
| 136 | positive regulation of T cell mediated cytotoxicity (GO:0001916) | 2.87782245 |
| 137 | regulation of T cell mediated cytotoxicity (GO:0001914) | 2.87067583 |
| 138 | positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516) | 2.86202948 |
| 139 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 2.85376603 |
| 140 | CD4-positive, alpha-beta T cell differentiation (GO:0043367) | 2.84635170 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 7.44217084 |
| 2 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 5.83786101 |
| 3 | E2F7_22180533_ChIP-Seq_HELA_Human | 5.52441508 |
| 4 | MYC_22102868_ChIP-Seq_BL_Human | 4.34247571 |
| 5 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 3.66774851 |
| 6 | RUNX_20019798_ChIP-Seq_JUKART_Human | 3.51828580 |
| 7 | FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse | 3.43746095 |
| 8 | STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 3.37691532 |
| 9 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 3.36750166 |
| 10 | MYB_26560356_Chip-Seq_TH2_Human | 3.24012940 |
| 11 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 3.11189659 |
| 12 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 3.01439926 |
| 13 | MAF_26560356_Chip-Seq_TH1_Human | 2.96120567 |
| 14 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 2.94370863 |
| 15 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 2.89961341 |
| 16 | UTX_26944678_Chip-Seq_JUKART_Human | 2.85849981 |
| 17 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 2.78421476 |
| 18 | MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 2.65429859 |
| 19 | MYB_26560356_Chip-Seq_TH1_Human | 2.57038363 |
| 20 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 2.56310853 |
| 21 | VDR_21846776_ChIP-Seq_THP-1_Human | 2.38853244 |
| 22 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 2.34618689 |
| 23 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 2.33512335 |
| 24 | KDM2B_26808549_Chip-Seq_HPB-ALL_Human | 2.28891243 |
| 25 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 2.25300725 |
| 26 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 2.22862298 |
| 27 | MAF_26560356_Chip-Seq_TH2_Human | 2.17597476 |
| 28 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 2.13184418 |
| 29 | TCF7_22412390_ChIP-Seq_EML_Mouse | 2.07649483 |
| 30 | GATA3_27048872_Chip-Seq_THYMUS_Human | 2.06570906 |
| 31 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 2.05464727 |
| 32 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.97763616 |
| 33 | KDM2B_26808549_Chip-Seq_DND41_Human | 1.88999796 |
| 34 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 1.88060289 |
| 35 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 1.83988364 |
| 36 | RUNX1_22412390_ChIP-Seq_EML_Mouse | 1.79281536 |
| 37 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 1.78456762 |
| 38 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 1.73064726 |
| 39 | SCL_19346495_ChIP-Seq_HPC-7_Human | 1.72510311 |
| 40 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.72169187 |
| 41 | E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 1.71757020 |
| 42 | VDR_24763502_ChIP-Seq_THP-1_Human | 1.70816169 |
| 43 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.69866180 |
| 44 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.68984896 |
| 45 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 1.63691805 |
| 46 | SPI1_23547873_ChIP-Seq_NB4_Human | 1.61652553 |
| 47 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.57029879 |
| 48 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.50434545 |
| 49 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 1.49639836 |
| 50 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.48626166 |
| 51 | VDR_23849224_ChIP-Seq_CD4+_Human | 1.40298656 |
| 52 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 1.40184353 |
| 53 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.39733341 |
| 54 | RUNX1_17652178_ChIP-ChIP_JURKAT_Human | 1.39269109 |
| 55 | NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse | 1.36873961 |
| 56 | SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse | 1.34959463 |
| 57 | BRD4_27068464_Chip-Seq_AML-cells_Mouse | 1.34406415 |
| 58 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.32338648 |
| 59 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.29916216 |
| 60 | GATA2_20887958_ChIP-Seq_HPC-7_Mouse | 1.28753253 |
| 61 | SPI1_23127762_ChIP-Seq_K562_Human | 1.26879491 |
| 62 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.26753082 |
| 63 | KDM2B_26808549_Chip-Seq_JURKAT_Human | 1.25707136 |
| 64 | MEIS1_20887958_ChIP-Seq_HPC-7_Mouse | 1.22961515 |
| 65 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.22434767 |
| 66 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 1.21563518 |
| 67 | BCL6_27268052_Chip-Seq_Bcells_Human | 1.20971233 |
| 68 | IRF8_27001747_Chip-Seq_BMDM_Mouse | 1.17085863 |
| 69 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 1.15462097 |
| 70 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.14440279 |
| 71 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 1.13745403 |
| 72 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.13528980 |
| 73 | VDR_24787735_ChIP-Seq_THP-1_Human | 1.12333332 |
| 74 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 1.12262250 |
| 75 | GATA2_22383799_ChIP-Seq_G1ME_Mouse | 1.10788923 |
| 76 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.10566829 |
| 77 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 1.09796282 |
| 78 | GATA3_26560356_Chip-Seq_TH2_Human | 1.08126600 |
| 79 | P300_27268052_Chip-Seq_Bcells_Human | 1.06285149 |
| 80 | TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse | 1.06266925 |
| 81 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.05908128 |
| 82 | BCOR_27268052_Chip-Seq_Bcells_Human | 1.02722668 |
| 83 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 1.02501974 |
| 84 | GATA3_26560356_Chip-Seq_TH1_Human | 1.01420189 |
| 85 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.00201765 |
| 86 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 0.99636880 |
| 87 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 0.98201533 |
| 88 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 0.98091972 |
| 89 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 0.97101508 |
| 90 | RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.95958207 |
| 91 | PU_27001747_Chip-Seq_BMDM_Mouse | 0.95434674 |
| 92 | KDM5A_27292631_Chip-Seq_BREAST_Human | 0.94877338 |
| 93 | CHD7_19251738_ChIP-ChIP_MESCs_Mouse | 0.94077848 |
| 94 | GATA1_19941826_ChIP-Seq_K562_Human | 0.93331260 |
| 95 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 0.92725595 |
| 96 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 0.92374903 |
| 97 | CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse | 0.90620531 |
| 98 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 0.89966375 |
| 99 | TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.88789878 |
| 100 | NCOR1_26117541_ChIP-Seq_K562_Human | 0.88746617 |
| 101 | PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse | 0.88405514 |
| 102 | CTCF_26484167_Chip-Seq_Bcells_Mouse | 0.88065605 |
| 103 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 0.87283066 |
| 104 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 0.86706992 |
| 105 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 0.86384295 |
| 106 | RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.85425885 |
| 107 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.84831094 |
| 108 | TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.84824509 |
| 109 | STAT1_20625510_ChIP-Seq_HELA_Human | 0.82608209 |
| 110 | VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human | 0.82565801 |
| 111 | GATA1_22383799_ChIP-Seq_G1ME_Mouse | 0.82097812 |
| 112 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 0.81861224 |
| 113 | PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse | 0.81769971 |
| 114 | GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.80934790 |
| 115 | RBPJ_21746931_ChIP-Seq_IB4-LCL_Human | 0.80468111 |
| 116 | PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 0.79712849 |
| 117 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 0.79622042 |
| 118 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 0.79535238 |
| 119 | CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 0.79118012 |
| 120 | CTCF_27219007_Chip-Seq_ERYTHROID_Human | 0.78952324 |
| 121 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 0.78700911 |
| 122 | CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 0.78224959 |
| 123 | PU.1_20513432_ChIP-Seq_Bcells_Mouse | 0.77311794 |
| 124 | SMRT_27268052_Chip-Seq_Bcells_Human | 0.77255972 |
| 125 | PBX1_22567123_ChIP-ChIP_OVCAR3_Human | 0.76578652 |
| 126 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 0.75337266 |
| 127 | CTCF_20526341_ChIP-Seq_ESCs_Human | 0.74264922 |
| 128 | CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse | 0.73782198 |
| 129 | PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse | 0.73649072 |
| 130 | CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse | 0.71139608 |
| 131 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 0.70950882 |
| 132 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 0.70322972 |
| 133 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 0.68533019 |
| 134 | LMO2_20887958_ChIP-Seq_HPC-7_Mouse | 0.66828137 |
| 135 | LXR_22292898_ChIP-Seq_THP-1_Human | 0.65285507 |
| 136 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 0.65228191 |
| 137 | GABP_19822575_ChIP-Seq_HepG2_Human | 0.64259229 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003763_abnormal_thymus_physiology | 6.88330715 |
| 2 | MP0005671_abnormal_response_to | 4.13123950 |
| 3 | MP0000685_abnormal_immune_system | 3.63793278 |
| 4 | MP0000703_abnormal_thymus_morphology | 3.44499667 |
| 5 | MP0009333_abnormal_splenocyte_physiolog | 3.36806386 |
| 6 | MP0002398_abnormal_bone_marrow | 3.07476537 |
| 7 | MP0002166_altered_tumor_susceptibility | 3.02905358 |
| 8 | MP0001800_abnormal_humoral_immune | 2.93151285 |
| 9 | MP0002420_abnormal_adaptive_immunity | 2.72438373 |
| 10 | MP0005000_abnormal_immune_tolerance | 2.70157563 |
| 11 | MP0001819_abnormal_immune_cell | 2.67680287 |
| 12 | MP0001835_abnormal_antigen_presentation | 2.65745195 |
| 13 | MP0002405_respiratory_system_inflammati | 2.62283719 |
| 14 | MP0002722_abnormal_immune_system | 2.61781969 |
| 15 | MP0001790_abnormal_immune_system | 2.59858963 |
| 16 | MP0005387_immune_system_phenotype | 2.59858963 |
| 17 | MP0002723_abnormal_immune_serum | 2.59370171 |
| 18 | MP0000716_abnormal_immune_system | 2.57160003 |
| 19 | MP0003300_gastrointestinal_ulcer | 2.55511034 |
| 20 | MP0002396_abnormal_hematopoietic_system | 2.51883764 |
| 21 | MP0002006_tumorigenesis | 2.43853800 |
| 22 | MP0004381_abnormal_hair_follicle | 2.42104449 |
| 23 | MP0000689_abnormal_spleen_morphology | 2.41978085 |
| 24 | MP0002452_abnormal_antigen_presenting | 2.33611314 |
| 25 | MP0003436_decreased_susceptibility_to | 2.25876843 |
| 26 | MP0003866_abnormal_defecation | 2.24161923 |
| 27 | MP0002429_abnormal_blood_cell | 2.10990048 |
| 28 | MP0010155_abnormal_intestine_physiology | 2.10047302 |
| 29 | MP0002277_abnormal_respiratory_mucosa | 2.09332602 |
| 30 | MP0005025_abnormal_response_to | 2.04448081 |
| 31 | MP0009785_altered_susceptibility_to | 2.02335967 |
| 32 | MP0004947_skin_inflammation | 2.01332932 |
| 33 | MP0004808_abnormal_hematopoietic_stem | 1.93457434 |
| 34 | MP0003303_peritoneal_inflammation | 1.85377393 |
| 35 | MP0001873_stomach_inflammation | 1.84719033 |
| 36 | MP0006082_CNS_inflammation | 1.83392711 |
| 37 | MP0003724_increased_susceptibility_to | 1.82085583 |
| 38 | MP0003191_abnormal_cellular_cholesterol | 1.76390246 |
| 39 | MP0002933_joint_inflammation | 1.64252959 |
| 40 | MP0005464_abnormal_platelet_physiology | 1.61222027 |
| 41 | MP0001853_heart_inflammation | 1.59248583 |
| 42 | MP0004510_myositis | 1.58460007 |
| 43 | MP0001845_abnormal_inflammatory_respons | 1.53478251 |
| 44 | MP0002148_abnormal_hypersensitivity_rea | 1.47058746 |
| 45 | MP0005075_abnormal_melanosome_morpholog | 1.46405996 |
| 46 | MP0002419_abnormal_innate_immunity | 1.40209256 |
| 47 | MP0000858_altered_metastatic_potential | 1.38509020 |
| 48 | MP0009697_abnormal_copulation | 1.33955001 |
| 49 | MP0008057_abnormal_DNA_replication | 1.33554614 |
| 50 | MP0000465_gastrointestinal_hemorrhage | 1.32423867 |
| 51 | MP0008961_abnormal_basal_metabolism | 1.20927371 |
| 52 | MP0000490_abnormal_crypts_of | 1.17854920 |
| 53 | MP0004957_abnormal_blastocyst_morpholog | 1.17521822 |
| 54 | MP0002019_abnormal_tumor_incidence | 1.17230068 |
| 55 | MP0001663_abnormal_digestive_system | 1.15075587 |
| 56 | MP0010094_abnormal_chromosome_stability | 1.14938756 |
| 57 | MP0001545_abnormal_hematopoietic_system | 1.13498888 |
| 58 | MP0005397_hematopoietic_system_phenotyp | 1.13498888 |
| 59 | MP0003077_abnormal_cell_cycle | 1.07906536 |
| 60 | MP0003693_abnormal_embryo_hatching | 1.04358843 |
| 61 | MP0003828_pulmonary_edema | 1.02153211 |
| 62 | MP0005310_abnormal_salivary_gland | 1.01589623 |
| 63 | MP0003448_altered_tumor_morphology | 1.00025477 |
| 64 | MP0010352_gastrointestinal_tract_polyps | 0.98927926 |
| 65 | MP0002693_abnormal_pancreas_physiology | 0.95736527 |
| 66 | MP0002009_preneoplasia | 0.95724181 |
| 67 | MP0008007_abnormal_cellular_replicative | 0.95668791 |
| 68 | MP0005076_abnormal_cell_differentiation | 0.93123704 |
| 69 | MP0005023_abnormal_wound_healing | 0.86833957 |
| 70 | MP0003315_abnormal_perineum_morphology | 0.86605768 |
| 71 | MP0008469_abnormal_protein_level | 0.85474888 |
| 72 | MP0001533_abnormal_skeleton_physiology | 0.84151293 |
| 73 | MP0005085_abnormal_gallbladder_physiolo | 0.81905742 |
| 74 | MP0009278_abnormal_bone_marrow | 0.81885288 |
| 75 | MP0001243_abnormal_dermal_layer | 0.79484329 |
| 76 | MP0009764_decreased_sensitivity_to | 0.78801111 |
| 77 | MP0002132_abnormal_respiratory_system | 0.76330268 |
| 78 | MP0003111_abnormal_nucleus_morphology | 0.75339227 |
| 79 | MP0001851_eye_inflammation | 0.75325376 |
| 80 | MP0000350_abnormal_cell_proliferation | 0.73780908 |
| 81 | MP0002998_abnormal_bone_remodeling | 0.72615860 |
| 82 | MP0000249_abnormal_blood_vessel | 0.72410262 |
| 83 | MP0001919_abnormal_reproductive_system | 0.69818420 |
| 84 | MP0005381_digestive/alimentary_phenotyp | 0.69469861 |
| 85 | MP0004883_abnormal_blood_vessel | 0.69400000 |
| 86 | MP0005647_abnormal_sex_gland | 0.69080179 |
| 87 | MP0003868_abnormal_feces_composition | 0.67217234 |
| 88 | MP0002138_abnormal_hepatobiliary_system | 0.66679475 |
| 89 | MP0004142_abnormal_muscle_tone | 0.66188086 |
| 90 | MP0000609_abnormal_liver_physiology | 0.65690895 |
| 91 | MP0001730_embryonic_growth_arrest | 0.65125844 |
| 92 | MP0009765_abnormal_xenobiotic_induced | 0.63571278 |
| 93 | MP0000313_abnormal_cell_death | 0.60725012 |
| 94 | MP0004185_abnormal_adipocyte_glucose | 0.60444257 |
| 95 | MP0000477_abnormal_intestine_morphology | 0.59484414 |
| 96 | MP0003795_abnormal_bone_structure | 0.57469473 |
| 97 | MP0005535_abnormal_body_temperature | 0.56340209 |
| 98 | MP0008995_early_reproductive_senescence | 0.55569455 |
| 99 | MP0003638_abnormal_response/metabolism_ | 0.55225368 |
| 100 | MP0002928_abnormal_bile_duct | 0.54242030 |
| 101 | MP0009763_increased_sensitivity_to | 0.52136330 |
| 102 | MP0008770_decreased_survivor_rate | 0.51089097 |
| 103 | MP0005451_abnormal_body_composition | 0.50433000 |
| 104 | MP0005174_abnormal_tail_pigmentation | 0.50202083 |
| 105 | MP0008004_abnormal_stomach_pH | 0.50164809 |
| 106 | MP0002970_abnormal_white_adipose | 0.49554348 |
| 107 | MP0006054_spinal_hemorrhage | 0.48837109 |
| 108 | MP0001119_abnormal_female_reproductive | 0.48195001 |
| 109 | MP0001348_abnormal_lacrimal_gland | 0.48079391 |
| 110 | MP0002971_abnormal_brown_adipose | 0.47618247 |
| 111 | MP0002653_abnormal_ependyma_morphology | 0.47371795 |
| 112 | MP0009115_abnormal_fat_cell | 0.46751401 |
| 113 | MP0000367_abnormal_coat/_hair | 0.45242095 |
| 114 | MP0001216_abnormal_epidermal_layer | 0.45235119 |
| 115 | MP0008877_abnormal_DNA_methylation | 0.45215483 |
| 116 | MP0005166_decreased_susceptibility_to | 0.44377837 |
| 117 | MP0009642_abnormal_blood_homeostasis | 0.43708151 |
| 118 | MP0002136_abnormal_kidney_physiology | 0.43517887 |
| 119 | MP0002083_premature_death | 0.43176426 |
| 120 | MP0002163_abnormal_gland_morphology | 0.42837335 |
| 121 | MP0008873_increased_physiological_sensi | 0.42429330 |
| 122 | MP0008569_lethality_at_weaning | 0.42179067 |
| 123 | MP0002095_abnormal_skin_pigmentation | 0.42075807 |
| 124 | MP0008058_abnormal_DNA_repair | 0.41932752 |
| 125 | MP0002080_prenatal_lethality | 0.41598896 |
| 126 | MP0005330_cardiomyopathy | 0.40902227 |
| 127 | MP0001905_abnormal_dopamine_level | 0.40462815 |
| 128 | MP0003959_abnormal_lean_body | 0.40079453 |
| 129 | MP0000377_abnormal_hair_follicle | 0.39991627 |
| 130 | MP0002086_abnormal_extraembryonic_tissu | 0.39907569 |
| 131 | MP0003137_abnormal_impulse_conducting | 0.39674615 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | T lymphocytopenia (HP:0005403) | 9.29307179 |
| 2 | Abnormality of T cell number (HP:0011839) | 8.86014266 |
| 3 | Aplastic anemia (HP:0001915) | 7.89517504 |
| 4 | Severe combined immunodeficiency (HP:0004430) | 6.91695919 |
| 5 | Combined immunodeficiency (HP:0005387) | 6.59208046 |
| 6 | Abnormality of T cells (HP:0002843) | 5.83927892 |
| 7 | Abnormality of macrophages (HP:0004311) | 5.47523552 |
| 8 | Elevated erythrocyte sedimentation rate (HP:0003565) | 5.20013513 |
| 9 | Panhypogammaglobulinemia (HP:0003139) | 5.17104375 |
| 10 | Recurrent viral infections (HP:0004429) | 5.03282801 |
| 11 | Stomatitis (HP:0010280) | 4.87595914 |
| 12 | Eosinophilia (HP:0001880) | 4.79183080 |
| 13 | Abnormality of eosinophils (HP:0001879) | 4.70042036 |
| 14 | Recurrent fungal infections (HP:0002841) | 4.69234880 |
| 15 | IgG deficiency (HP:0004315) | 4.64877491 |
| 16 | Chronic otitis media (HP:0000389) | 4.59672798 |
| 17 | Abnormality of B cell number (HP:0010975) | 4.58899396 |
| 18 | B lymphocytopenia (HP:0010976) | 4.58899396 |
| 19 | Recurrent bronchitis (HP:0002837) | 4.54991870 |
| 20 | Thyroiditis (HP:0100646) | 4.47891636 |
| 21 | Nasal polyposis (HP:0100582) | 4.10636703 |
| 22 | Granulocytopenia (HP:0001913) | 4.04451533 |
| 23 | Optic neuritis (HP:0100653) | 3.93076444 |
| 24 | Retrobulbar optic neuritis (HP:0100654) | 3.93076444 |
| 25 | Leukocytosis (HP:0001974) | 3.89405532 |
| 26 | Abnormality of the fingertips (HP:0001211) | 3.78809195 |
| 27 | IgM deficiency (HP:0002850) | 3.78788644 |
| 28 | Hypoplasia of the thymus (HP:0000778) | 3.77783137 |
| 29 | Orchitis (HP:0100796) | 3.74986218 |
| 30 | Lip pit (HP:0100267) | 3.68099251 |
| 31 | Abnormal delayed hypersensitivity skin test (HP:0002963) | 3.66414759 |
| 32 | Chronic mucocutaneous candidiasis (HP:0002728) | 3.58560817 |
| 33 | Recurrent cutaneous fungal infections (HP:0011370) | 3.58560817 |
| 34 | Recurrent bacterial skin infections (HP:0005406) | 3.57535995 |
| 35 | Autoimmune hemolytic anemia (HP:0001890) | 3.50138032 |
| 36 | Recurrent abscess formation (HP:0002722) | 3.44076049 |
| 37 | Abnormality of the nasal mucosa (HP:0000433) | 3.40139102 |
| 38 | Increased IgM level (HP:0003496) | 3.35419025 |
| 39 | Posterior subcapsular cataract (HP:0007787) | 3.33241522 |
| 40 | Microretrognathia (HP:0000308) | 3.25568606 |
| 41 | Chronic diarrhea (HP:0002028) | 3.23482825 |
| 42 | Lymphopenia (HP:0001888) | 3.23167685 |
| 43 | Joint swelling (HP:0001386) | 3.19351975 |
| 44 | Keratoconjunctivitis sicca (HP:0001097) | 3.18909184 |
| 45 | Abnormality of cells of the lymphoid lineage (HP:0012140) | 3.16576219 |
| 46 | Pustule (HP:0200039) | 3.16484816 |
| 47 | Eczematoid dermatitis (HP:0000976) | 3.12251545 |
| 48 | Gangrene (HP:0100758) | 3.06672893 |
| 49 | Abnormality of the prostate (HP:0008775) | 3.06525388 |
| 50 | Limb dystonia (HP:0002451) | 3.04394959 |
| 51 | Basal cell carcinoma (HP:0002671) | 3.04096329 |
| 52 | Abnormality of T cell physiology (HP:0011840) | 3.01937776 |
| 53 | Keratoconjunctivitis (HP:0001096) | 2.94770906 |
| 54 | Ileus (HP:0002595) | 2.94285916 |
| 55 | Autoimmune thrombocytopenia (HP:0001973) | 2.83964260 |
| 56 | Lymphoma (HP:0002665) | 2.80863263 |
| 57 | Abnormality of cells of the erythroid lineage (HP:0012130) | 2.73461451 |
| 58 | Slow saccadic eye movements (HP:0000514) | 2.69008324 |
| 59 | Abnormal platelet volume (HP:0011876) | 2.67152111 |
| 60 | Spontaneous hematomas (HP:0007420) | 2.66635022 |
| 61 | Hypoproteinemia (HP:0003075) | 2.65981873 |
| 62 | Hypochromic microcytic anemia (HP:0004840) | 2.65478080 |
| 63 | Verrucae (HP:0200043) | 2.58654106 |
| 64 | Papilloma (HP:0012740) | 2.58654106 |
| 65 | Thrombocytosis (HP:0001894) | 2.58526672 |
| 66 | Bronchitis (HP:0012387) | 2.56358114 |
| 67 | Abnormal number of erythroid precursors (HP:0012131) | 2.54018675 |
| 68 | Conjugated hyperbilirubinemia (HP:0002908) | 2.50307320 |
| 69 | Impaired proprioception (HP:0010831) | 2.45635658 |
| 70 | Myositis (HP:0100614) | 2.44945877 |
| 71 | Meningitis (HP:0001287) | 2.42809900 |
| 72 | Gastrointestinal infarctions (HP:0005244) | 2.42297478 |
| 73 | IgA deficiency (HP:0002720) | 2.41832729 |
| 74 | Recurrent gram-negative bacterial infections (HP:0005420) | 2.41740968 |
| 75 | Hypergammaglobulinemia (HP:0010702) | 2.41647672 |
| 76 | Bicuspid aortic valve (HP:0001647) | 2.41408953 |
| 77 | Glomerulopathy (HP:0100820) | 2.39327501 |
| 78 | Increased IgE level (HP:0003212) | 2.37999981 |
| 79 | Amyotrophic lateral sclerosis (HP:0007354) | 2.36877133 |
| 80 | Aplasia/Hypoplasia of the thymus (HP:0010515) | 2.33448938 |
| 81 | Sensorimotor neuropathy (HP:0007141) | 2.30898315 |
| 82 | 3-Methylglutaconic aciduria (HP:0003535) | 2.29211590 |
| 83 | Chronic sinusitis (HP:0011109) | 2.21024522 |
| 84 | Increased density of long bones (HP:0006392) | 2.20854418 |
| 85 | Encephalitis (HP:0002383) | 2.20755573 |
| 86 | Increased mean platelet volume (HP:0011877) | 2.19118170 |
| 87 | Broad alveolar ridges (HP:0000187) | 2.18594848 |
| 88 | Mediastinal lymphadenopathy (HP:0100721) | 2.18397170 |
| 89 | Reticulocytopenia (HP:0001896) | 2.18006248 |
| 90 | Milia (HP:0001056) | 2.16547122 |
| 91 | Absent rod-and cone-mediated responses on ERG (HP:0007688) | 2.13971740 |
| 92 | Polyneuropathy (HP:0001271) | 2.12849274 |
| 93 | Gastrointestinal inflammation (HP:0004386) | 2.09784502 |
| 94 | Recurrent otitis media (HP:0000403) | 2.08886232 |
| 95 | Inflammation of the large intestine (HP:0002037) | 2.08272314 |
| 96 | Amaurosis fugax (HP:0100576) | 2.05909064 |
| 97 | Type I diabetes mellitus (HP:0100651) | 2.04333320 |
| 98 | Volvulus (HP:0002580) | 2.03596744 |
| 99 | Abnormality of the pleura (HP:0002103) | 2.00484111 |
| 100 | Obstructive lung disease (HP:0006536) | 1.99159890 |
| 101 | Chronic obstructive pulmonary disease (HP:0006510) | 1.99159890 |
| 102 | Macrocytic anemia (HP:0001972) | 1.98424523 |
| 103 | Osteomyelitis (HP:0002754) | 1.98250273 |
| 104 | Sepsis (HP:0100806) | 1.98086959 |
| 105 | Prolonged bleeding time (HP:0003010) | 1.97819678 |
| 106 | Pulmonary fibrosis (HP:0002206) | 1.97236375 |
| 107 | Hemoptysis (HP:0002105) | 1.96617481 |
| 108 | Abnormality of small intestinal villus morphology (HP:0011472) | 1.96579246 |
| 109 | Villous atrophy (HP:0011473) | 1.96579246 |
| 110 | Epistaxis (HP:0000421) | 1.96255293 |
| 111 | Recurrent sinusitis (HP:0011108) | 1.96040841 |
| 112 | Vasculitis (HP:0002633) | 1.94832558 |
| 113 | Dysphonia (HP:0001618) | 1.94491352 |
| 114 | Limb hypertonia (HP:0002509) | 1.94103263 |
| 115 | Facial hemangioma (HP:0000329) | 1.93509807 |
| 116 | Cutis marmorata (HP:0000965) | 1.92920819 |
| 117 | Recurrent skin infections (HP:0001581) | 1.92743221 |
| 118 | Abnormality of the thymus (HP:0000777) | 1.87085934 |
| 119 | Agammaglobulinemia (HP:0004432) | 1.86230866 |
| 120 | Hypochromic anemia (HP:0001931) | 1.85406812 |
| 121 | Chest pain (HP:0100749) | 1.84968748 |
| 122 | Periodontitis (HP:0000704) | 1.82716190 |
| 123 | Cellular immunodeficiency (HP:0005374) | 1.80476163 |
| 124 | Ureteral stenosis (HP:0000071) | 1.79051127 |
| 125 | Poikiloderma (HP:0001029) | 1.78687871 |
| 126 | Hepatitis (HP:0012115) | 1.74944125 |
| 127 | Pallor (HP:0000980) | 1.74751997 |
| 128 | Gingival bleeding (HP:0000225) | 1.72777241 |
| 129 | Petechiae (HP:0000967) | 1.72070941 |
| 130 | Dislocated radial head (HP:0003083) | 1.71630660 |
| 131 | Cheilitis (HP:0100825) | 1.67153994 |
| 132 | Abnormality of oral frenula (HP:0000190) | 1.66342909 |
| 133 | Bronchiectasis (HP:0002110) | 1.66299942 |
| 134 | Fatigue (HP:0012378) | 1.65330110 |
| 135 | Microcytic anemia (HP:0001935) | 1.63619800 |
| 136 | Pulmonary infiltrates (HP:0002113) | 1.61812825 |
| 137 | Pulmonary embolism (HP:0002204) | 1.61564574 |
| 138 | Ureteral obstruction (HP:0006000) | 1.58872859 |
| 139 | Entropion (HP:0000621) | 1.58764783 |
| 140 | Abnormality of the radial head (HP:0003995) | 1.58607002 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MAP4K1 | 5.78248280 |
| 2 | TXK | 5.69842056 |
| 3 | ZAP70 | 3.60193187 |
| 4 | ITK | 3.24002867 |
| 5 | STK10 | 2.81240069 |
| 6 | NLK | 2.79061726 |
| 7 | GRK6 | 2.72172004 |
| 8 | MAP3K6 | 2.64062639 |
| 9 | JAK3 | 2.58054760 |
| 10 | FGFR4 | 2.56749598 |
| 11 | EEF2K | 2.44666352 |
| 12 | PKN2 | 2.21157733 |
| 13 | MST4 | 2.19210251 |
| 14 | MAP3K10 | 2.09512784 |
| 15 | NME2 | 2.09502344 |
| 16 | TYK2 | 2.05456064 |
| 17 | DYRK3 | 1.94864343 |
| 18 | IKBKE | 1.92288006 |
| 19 | CAMKK2 | 1.85247114 |
| 20 | AKT3 | 1.81332940 |
| 21 | LCK | 1.80827194 |
| 22 | RIPK4 | 1.80260255 |
| 23 | FGFR3 | 1.73021468 |
| 24 | LRRK2 | 1.73019887 |
| 25 | CSK | 1.57771137 |
| 26 | SYK | 1.54977373 |
| 27 | TEC | 1.53680928 |
| 28 | TRIB3 | 1.51541333 |
| 29 | MAP3K14 | 1.38686222 |
| 30 | JAK1 | 1.36188689 |
| 31 | CDK12 | 1.34063733 |
| 32 | NUAK1 | 1.33293388 |
| 33 | HCK | 1.29240358 |
| 34 | CLK1 | 1.27331861 |
| 35 | PRKCQ | 1.27169354 |
| 36 | MAP3K2 | 1.23443571 |
| 37 | MAP3K11 | 1.23211291 |
| 38 | MAP3K5 | 1.21095440 |
| 39 | PRKCH | 1.20467671 |
| 40 | BTK | 1.15670933 |
| 41 | CDK19 | 1.13285303 |
| 42 | TESK2 | 1.09757853 |
| 43 | CAMKK1 | 1.08589596 |
| 44 | RAF1 | 1.07226170 |
| 45 | CDC7 | 1.03462693 |
| 46 | RPS6KA4 | 1.03110066 |
| 47 | MAP3K7 | 1.00804634 |
| 48 | PDGFRB | 0.98669535 |
| 49 | TBK1 | 0.98657975 |
| 50 | PIM1 | 0.93284256 |
| 51 | TAOK3 | 0.90551095 |
| 52 | TYRO3 | 0.89185434 |
| 53 | MARK3 | 0.88504562 |
| 54 | SCYL2 | 0.88426121 |
| 55 | FES | 0.88305553 |
| 56 | ALK | 0.87132105 |
| 57 | YES1 | 0.86840555 |
| 58 | SIK2 | 0.86048158 |
| 59 | KDR | 0.86014954 |
| 60 | MAP3K13 | 0.85249283 |
| 61 | PASK | 0.82112574 |
| 62 | UHMK1 | 0.81394024 |
| 63 | TNK2 | 0.80131777 |
| 64 | FGR | 0.79007392 |
| 65 | IKBKB | 0.78325766 |
| 66 | JAK2 | 0.76119080 |
| 67 | CDK4 | 0.74227232 |
| 68 | CHUK | 0.73463610 |
| 69 | VRK1 | 0.72070214 |
| 70 | HIPK2 | 0.70557010 |
| 71 | TSSK6 | 0.70499389 |
| 72 | RPS6KB2 | 0.69252439 |
| 73 | STK4 | 0.66558763 |
| 74 | TRPM7 | 0.65648321 |
| 75 | DYRK1B | 0.64052656 |
| 76 | TAOK1 | 0.62516674 |
| 77 | EPHB1 | 0.60873303 |
| 78 | CDC42BPA | 0.60370916 |
| 79 | LYN | 0.58698053 |
| 80 | STK38 | 0.58590809 |
| 81 | BLK | 0.57253304 |
| 82 | BRD4 | 0.57176558 |
| 83 | INSR | 0.55621021 |
| 84 | ERN1 | 0.55470576 |
| 85 | MARK2 | 0.54293602 |
| 86 | FGFR1 | 0.53606359 |
| 87 | MAPK7 | 0.52895055 |
| 88 | PTK6 | 0.51321388 |
| 89 | CDK6 | 0.50519829 |
| 90 | MAP3K3 | 0.50358977 |
| 91 | PRPF4B | 0.49298932 |
| 92 | NEK2 | 0.48757210 |
| 93 | MELK | 0.48005607 |
| 94 | SIK3 | 0.46675803 |
| 95 | PDK1 | 0.46287313 |
| 96 | MAP3K8 | 0.44736209 |
| 97 | MAPKAPK2 | 0.44650101 |
| 98 | ILK | 0.44221010 |
| 99 | FLT3 | 0.44149362 |
| 100 | TGFBR1 | 0.43551057 |
| 101 | CDK9 | 0.43455127 |
| 102 | KIT | 0.43323166 |
| 103 | PIK3CG | 0.42464691 |
| 104 | CSF1R | 0.42013705 |
| 105 | FGFR2 | 0.41862326 |
| 106 | FYN | 0.41500630 |
| 107 | MAPK11 | 0.40695902 |
| 108 | MAPK12 | 0.39163680 |
| 109 | BRSK1 | 0.38513665 |
| 110 | GRK7 | 0.37075835 |
| 111 | TAOK2 | 0.36844404 |
| 112 | TTN | 0.35830363 |
| 113 | MAPK4 | 0.35658745 |
| 114 | CHEK1 | 0.33797239 |
| 115 | SIK1 | 0.33218033 |
| 116 | MAP2K6 | 0.32704261 |
| 117 | MKNK2 | 0.31903816 |
| 118 | TGFBR2 | 0.31291653 |
| 119 | STK11 | 0.30582398 |
| 120 | BRAF | 0.30558611 |
| 121 | MAP2K3 | 0.29943856 |
| 122 | SGK2 | 0.29626719 |
| 123 | DMPK | 0.28947130 |
| 124 | NTRK2 | 0.28682533 |
| 125 | SGK3 | 0.27075483 |
| 126 | ROCK2 | 0.26631831 |
| 127 | MAPK3 | 0.24726948 |
| 128 | EPHA3 | 0.24639475 |
| 129 | IGF1R | 0.24374053 |
| 130 | IRAK4 | 0.23789950 |
| 131 | RPS6KL1 | 0.23383632 |
| 132 | RPS6KC1 | 0.23383632 |
| 133 | ATR | 0.23209653 |
| 134 | PRKD2 | 0.22984682 |
| 135 | EGFR | 0.22480724 |
| 136 | RPS6KA5 | 0.22322876 |
| 137 | DYRK1A | 0.21459292 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Primary immunodeficiency_Homo sapiens_hsa05340 | 6.32118185 |
| 2 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 4.50506603 |
| 3 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 2.84494345 |
| 4 | Measles_Homo sapiens_hsa05162 | 2.76891836 |
| 5 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 2.70280768 |
| 6 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 2.46966137 |
| 7 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 2.46653660 |
| 8 | Ribosome_Homo sapiens_hsa03010 | 2.41396630 |
| 9 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 2.26640637 |
| 10 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 2.23782349 |
| 11 | Antigen processing and presentation_Homo sapiens_hsa04612 | 2.20321812 |
| 12 | Allograft rejection_Homo sapiens_hsa05330 | 2.15311289 |
| 13 | Other glycan degradation_Homo sapiens_hsa00511 | 2.14306663 |
| 14 | Non-homologous end-joining_Homo sapiens_hsa03450 | 2.05155853 |
| 15 | RNA polymerase_Homo sapiens_hsa03020 | 1.85887624 |
| 16 | Viral myocarditis_Homo sapiens_hsa05416 | 1.83127860 |
| 17 | Graft-versus-host disease_Homo sapiens_hsa05332 | 1.81369541 |
| 18 | Osteoclast differentiation_Homo sapiens_hsa04380 | 1.70416156 |
| 19 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 1.70014960 |
| 20 | Spliceosome_Homo sapiens_hsa03040 | 1.64657798 |
| 21 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 1.62815952 |
| 22 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 1.48830416 |
| 23 | Herpes simplex infection_Homo sapiens_hsa05168 | 1.48684446 |
| 24 | Leishmaniasis_Homo sapiens_hsa05140 | 1.48295987 |
| 25 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 1.43492478 |
| 26 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.39910122 |
| 27 | Regulation of autophagy_Homo sapiens_hsa04140 | 1.38321252 |
| 28 | Colorectal cancer_Homo sapiens_hsa05210 | 1.37187673 |
| 29 | HTLV-I infection_Homo sapiens_hsa05166 | 1.36699294 |
| 30 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 1.35554436 |
| 31 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 1.34593522 |
| 32 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 1.33790992 |
| 33 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 1.31223421 |
| 34 | DNA replication_Homo sapiens_hsa03030 | 1.31166358 |
| 35 | Hepatitis B_Homo sapiens_hsa05161 | 1.28995318 |
| 36 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 1.27775211 |
| 37 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 1.27491822 |
| 38 | Thyroid cancer_Homo sapiens_hsa05216 | 1.21865849 |
| 39 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 1.17958674 |
| 40 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 1.12260622 |
| 41 | Toxoplasmosis_Homo sapiens_hsa05145 | 1.12095592 |
| 42 | Notch signaling pathway_Homo sapiens_hsa04330 | 1.11195924 |
| 43 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 1.10408743 |
| 44 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 1.08914560 |
| 45 | Shigellosis_Homo sapiens_hsa05131 | 1.08426317 |
| 46 | Pancreatic cancer_Homo sapiens_hsa05212 | 1.06151163 |
| 47 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.99744971 |
| 48 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.99503638 |
| 49 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.98651266 |
| 50 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.97309695 |
| 51 | Mismatch repair_Homo sapiens_hsa03430 | 0.93292933 |
| 52 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.92485172 |
| 53 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.92024858 |
| 54 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 0.91806373 |
| 55 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.91453527 |
| 56 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 0.89843103 |
| 57 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.88784271 |
| 58 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.86829977 |
| 59 | Amphetamine addiction_Homo sapiens_hsa05031 | 0.86585427 |
| 60 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.86227756 |
| 61 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.85938367 |
| 62 | Platelet activation_Homo sapiens_hsa04611 | 0.84900721 |
| 63 | Influenza A_Homo sapiens_hsa05164 | 0.84505841 |
| 64 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.83803433 |
| 65 | Apoptosis_Homo sapiens_hsa04210 | 0.83252180 |
| 66 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.82561129 |
| 67 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.81137087 |
| 68 | RNA transport_Homo sapiens_hsa03013 | 0.79846045 |
| 69 | Base excision repair_Homo sapiens_hsa03410 | 0.77059650 |
| 70 | Endometrial cancer_Homo sapiens_hsa05213 | 0.75841368 |
| 71 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.73351060 |
| 72 | Proteasome_Homo sapiens_hsa03050 | 0.73214923 |
| 73 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.71265021 |
| 74 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.70754289 |
| 75 | Long-term potentiation_Homo sapiens_hsa04720 | 0.70280750 |
| 76 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.70229281 |
| 77 | Hepatitis C_Homo sapiens_hsa05160 | 0.69851112 |
| 78 | TNF signaling pathway_Homo sapiens_hsa04668 | 0.68573259 |
| 79 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 0.68060154 |
| 80 | RNA degradation_Homo sapiens_hsa03018 | 0.66087911 |
| 81 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.65358585 |
| 82 | Prostate cancer_Homo sapiens_hsa05215 | 0.63553725 |
| 83 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.62063926 |
| 84 | One carbon pool by folate_Homo sapiens_hsa00670 | 0.60972393 |
| 85 | Asthma_Homo sapiens_hsa05310 | 0.60760036 |
| 86 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.60507902 |
| 87 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.59851691 |
| 88 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.57943386 |
| 89 | Legionellosis_Homo sapiens_hsa05134 | 0.56894629 |
| 90 | Cell cycle_Homo sapiens_hsa04110 | 0.55898576 |
| 91 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.54942279 |
| 92 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.50186470 |
| 93 | Adherens junction_Homo sapiens_hsa04520 | 0.46943450 |
| 94 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.46915330 |
| 95 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.46625351 |
| 96 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.44693103 |
| 97 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.44650441 |
| 98 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.44574677 |
| 99 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.44359220 |
| 100 | Tuberculosis_Homo sapiens_hsa05152 | 0.42607727 |
| 101 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.42506420 |
| 102 | Nucleotide excision repair_Homo sapiens_hsa03420 | 0.41672730 |
| 103 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.41235262 |
| 104 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.39146531 |
| 105 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.38773856 |
| 106 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.38676601 |
| 107 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.37237079 |
| 108 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.36786005 |
| 109 | Salmonella infection_Homo sapiens_hsa05132 | 0.36569033 |
| 110 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 0.36398259 |
| 111 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.35135100 |
| 112 | Endocytosis_Homo sapiens_hsa04144 | 0.34455103 |
| 113 | Pertussis_Homo sapiens_hsa05133 | 0.32815588 |
| 114 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.32381661 |
| 115 | Pathways in cancer_Homo sapiens_hsa05200 | 0.31932782 |
| 116 | Lysine degradation_Homo sapiens_hsa00310 | 0.30121767 |
| 117 | Insulin resistance_Homo sapiens_hsa04931 | 0.29762066 |
| 118 | Phagosome_Homo sapiens_hsa04145 | 0.29500102 |
| 119 | cAMP signaling pathway_Homo sapiens_hsa04024 | 0.29146048 |
| 120 | Malaria_Homo sapiens_hsa05144 | 0.28365836 |
| 121 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.27960924 |
| 122 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.27828091 |
| 123 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.26263538 |
| 124 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.22689041 |
| 125 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.21727095 |
| 126 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.19654881 |
| 127 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.18056597 |
| 128 | ABC transporters_Homo sapiens_hsa02010 | 0.14783480 |
| 129 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.14128799 |
| 130 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.11331686 |
| 131 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.10537069 |
| 132 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.09651111 |
| 133 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 0.09358431 |
| 134 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.09278279 |

