TRBV16

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative T cell selection (GO:0043383)8.53385778
2positive regulation of gamma-delta T cell activation (GO:0046645)8.33724973
3negative thymic T cell selection (GO:0045060)8.02891303
4regulation of gamma-delta T cell differentiation (GO:0045586)7.73156783
5positive T cell selection (GO:0043368)7.64214495
6positive thymic T cell selection (GO:0045059)7.59558594
7thymic T cell selection (GO:0045061)7.16379536
8T cell selection (GO:0045058)7.01149403
9positive regulation of interleukin-2 biosynthetic process (GO:0045086)6.90581112
10regulation of gamma-delta T cell activation (GO:0046643)6.89366529
11positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)6.86289127
12antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.65029957
13antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.65029957
14negative regulation of cell killing (GO:0031342)6.49459921
15negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.49459921
16response to interleukin-15 (GO:0070672)5.83451934
17T cell receptor signaling pathway (GO:0050852)5.80479081
18regulation of isotype switching to IgG isotypes (GO:0048302)5.66960853
19antigen processing and presentation of endogenous antigen (GO:0019883)5.50020380
20regulation of T cell tolerance induction (GO:0002664)5.40613102
21leukocyte aggregation (GO:0070486)5.25227993
22interferon-gamma production (GO:0032609)5.20371815
23T cell costimulation (GO:0031295)5.16621359
24T cell migration (GO:0072678)5.06993769
25lymphocyte costimulation (GO:0031294)5.06462658
26cellular response to interleukin-15 (GO:0071350)4.96599017
27regulation of interleukin-2 biosynthetic process (GO:0045076)4.87230507
28activated T cell proliferation (GO:0050798)4.74241388
29antigen receptor-mediated signaling pathway (GO:0050851)4.69028902
30positive regulation of interleukin-2 production (GO:0032743)4.67108496
31V(D)J recombination (GO:0033151)4.58976589
32positive regulation of tolerance induction (GO:0002645)4.44210143
33regulation of T cell receptor signaling pathway (GO:0050856)4.39748351
34regulation of regulatory T cell differentiation (GO:0045589)4.24096601
35regulation of interleukin-12 biosynthetic process (GO:0045075)4.21784941
36regulation of antigen receptor-mediated signaling pathway (GO:0050854)4.21453401
37mast cell activation (GO:0045576)4.17440402
38regulation of alpha-beta T cell proliferation (GO:0046640)4.17290913
39regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.93861418
40regulation of tolerance induction (GO:0002643)3.84716755
41positive regulation of alpha-beta T cell proliferation (GO:0046641)3.78824874
42T cell differentiation (GO:0030217)3.77622501
43ribosomal small subunit assembly (GO:0000028)3.77524557
44alpha-beta T cell activation (GO:0046631)3.67489474
45regulation of B cell receptor signaling pathway (GO:0050855)3.66605175
46alpha-beta T cell differentiation (GO:0046632)3.65369135
47mast cell degranulation (GO:0043303)3.65267981
48mast cell activation involved in immune response (GO:0002279)3.65267981
49positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.64307819
50positive regulation of natural killer cell mediated immunity (GO:0002717)3.64307819
51cellular response to interleukin-4 (GO:0071353)3.63189544
52regulation of natural killer cell mediated immunity (GO:0002715)3.60963763
53regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.60963763
54positive regulation of humoral immune response (GO:0002922)3.57738117
55viral transcription (GO:0019083)3.57602267
56negative regulation of T cell mediated immunity (GO:0002710)3.56398278
57positive regulation of isotype switching (GO:0045830)3.55310297
58T cell homeostasis (GO:0043029)3.55196378
59regulation of defense response to virus by virus (GO:0050690)3.54457454
60natural killer cell differentiation (GO:0001779)3.52904555
61negative regulation of erythrocyte differentiation (GO:0045647)3.49828036
62tolerance induction (GO:0002507)3.46417882
63response to interleukin-4 (GO:0070670)3.42369997
64translational termination (GO:0006415)3.38922650
65NIK/NF-kappaB signaling (GO:0038061)3.38298567
66regulation of isotype switching (GO:0045191)3.37036301
67regulation of interleukin-2 production (GO:0032663)3.36597417
68T cell activation (GO:0042110)3.30651429
69immune response-activating cell surface receptor signaling pathway (GO:0002429)3.26883143
70JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.17364317
71regulation of response to interferon-gamma (GO:0060330)3.15971706
72regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.13833510
73positive regulation of T cell activation (GO:0050870)3.13029312
74negative regulation of T cell receptor signaling pathway (GO:0050860)3.12779218
75natural killer cell activation (GO:0030101)3.10605723
76Peyers patch development (GO:0048541)3.10336172
77mucosal-associated lymphoid tissue development (GO:0048537)3.10336172
78lymphocyte homeostasis (GO:0002260)3.09624072
79positive regulation of T cell differentiation (GO:0045582)3.07749108
80positive regulation of B cell mediated immunity (GO:0002714)3.02028917
81positive regulation of immunoglobulin mediated immune response (GO:0002891)3.02028917
82regulation of B cell differentiation (GO:0045577)2.99121804
83leukocyte cell-cell adhesion (GO:0007159)2.98700573
84regulation of type I interferon-mediated signaling pathway (GO:0060338)2.98381727
85T cell proliferation (GO:0042098)2.97962461
86positive regulation of DNA recombination (GO:0045911)2.96682118
87positive regulation of granulocyte differentiation (GO:0030854)2.96472484
88translational elongation (GO:0006414)2.96423006
89regulation of immunoglobulin mediated immune response (GO:0002889)2.95155058
90negative regulation of lymphocyte mediated immunity (GO:0002707)2.91518839
91nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.89654738
92negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.88920042
93regulation of immunoglobulin production (GO:0002637)2.88022795
94regulation of leukocyte mediated cytotoxicity (GO:0001910)2.86374977
95ribosomal small subunit biogenesis (GO:0042274)2.86167733
96positive regulation of interleukin-4 production (GO:0032753)2.85028832
97regulation of alpha-beta T cell activation (GO:0046634)2.84763134
98positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.84225129
99regulation of B cell mediated immunity (GO:0002712)2.83889736
100positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.83359495

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse6.95359770
2E2F7_22180533_ChIP-Seq_HELA_Human6.67517430
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.48663524
4MYC_22102868_ChIP-Seq_BL_Human4.52852303
5FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.39113830
6EGR1_19374776_ChIP-ChIP_THP-1_Human3.37377503
7RUNX_20019798_ChIP-Seq_JUKART_Human3.33931544
8STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.24825210
9MYB_26560356_Chip-Seq_TH2_Human3.10058705
10MAF_26560356_Chip-Seq_TH1_Human2.98276717
11IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.96932281
12IRF8_22096565_ChIP-ChIP_GC-B_Human2.96505221
13UTX_26944678_Chip-Seq_JUKART_Human2.88494803
14IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.82740967
15STAT4_19710469_ChIP-ChIP_TH1__Mouse2.82138084
16NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.70408176
17VDR_21846776_ChIP-Seq_THP-1_Human2.69733781
18MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.63507111
19MYB_26560356_Chip-Seq_TH1_Human2.57310032
20KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.36662674
21TCF7_22412390_ChIP-Seq_EML_Mouse2.29491755
22EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.24115652
23SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.21717843
24MAF_26560356_Chip-Seq_TH2_Human2.18705955
25FOXM1_23109430_ChIP-Seq_U2OS_Human2.16848581
26KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.06196618
27KDM2B_26808549_Chip-Seq_DND41_Human2.06063112
28SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.01510582
29RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.95165802
30GATA3_27048872_Chip-Seq_THYMUS_Human1.94683426
31NOTCH1_21737748_ChIP-Seq_TLL_Human1.88556483
32E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.87319557
33RUNX1_22412390_ChIP-Seq_EML_Mouse1.78742867
34VDR_24763502_ChIP-Seq_THP-1_Human1.76846578
35SCL_19346495_ChIP-Seq_HPC-7_Human1.75323374
36ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.67288356
37MYB_21317192_ChIP-Seq_ERMYB_Mouse1.64226005
38CIITA_25753668_ChIP-Seq_RAJI_Human1.63196704
39KDM2B_26808549_Chip-Seq_SUP-B15_Human1.62285554
40SPI1_23547873_ChIP-Seq_NB4_Human1.56567674
41TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.55061179
42NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.51733438
43E2F4_17652178_ChIP-ChIP_JURKAT_Human1.50183245
44SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.43529765
45ELF1_17652178_ChIP-ChIP_JURKAT_Human1.42888219
46BRD4_27068464_Chip-Seq_AML-cells_Mouse1.41965416
47KDM2B_26808549_Chip-Seq_JURKAT_Human1.40016637
48VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.35584210
49SPI1_23127762_ChIP-Seq_K562_Human1.34832906
50FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.32414250
51ELK3_25401928_ChIP-Seq_HUVEC_Human1.30237418
52IRF8_21731497_ChIP-ChIP_J774_Mouse1.28682213
53IRF8_27001747_Chip-Seq_BMDM_Mouse1.26507052
54TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.25383561
55MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.24576072
56RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.23252294
57MYC_19079543_ChIP-ChIP_MESCs_Mouse1.20292286
58SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.18940398
59GATA2_22383799_ChIP-Seq_G1ME_Mouse1.14079648
60MYC_18555785_ChIP-Seq_MESCs_Mouse1.13039389
61TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12828871
62XRN2_22483619_ChIP-Seq_HELA_Human1.11874920
63FOXP3_21729870_ChIP-Seq_TREG_Human1.11042411
64VDR_23849224_ChIP-Seq_CD4+_Human1.06374516
65NCOR1_26117541_ChIP-Seq_K562_Human1.01883313
66RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.01563092
67GATA3_26560356_Chip-Seq_TH2_Human1.00335945
68GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.96059003
69NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.95415263
70PU_27001747_Chip-Seq_BMDM_Mouse0.94704558
71KDM5A_27292631_Chip-Seq_BREAST_Human0.94359317
72GATA1_22383799_ChIP-Seq_G1ME_Mouse0.94194783
73SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.93412401
74FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.91952906
75RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88622877
76LXR_22292898_ChIP-Seq_THP-1_Human0.87440954
77E2F1_21310950_ChIP-Seq_MCF-7_Human0.87402097
78PU.1_20513432_ChIP-Seq_Bcells_Mouse0.87025204
79GATA1_19941827_ChIP-Seq_MEL_Mouse0.85490727
80ERG_20887958_ChIP-Seq_HPC-7_Mouse0.85087473
81GATA1_19941826_ChIP-Seq_K562_Human0.84348884
82SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.83336181
83CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.82926279
84CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.81915068
85PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.81329421
86BP1_19119308_ChIP-ChIP_Hs578T_Human0.80783132
87FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80418830
88THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.78796596
89CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.76380928
90LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.75245713
91ELK1_19687146_ChIP-ChIP_HELA_Human0.74324541
92CTCF_27219007_Chip-Seq_ERYTHROID_Human0.73551186
93CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.72914757
94STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.71790724
95HOXB4_20404135_ChIP-ChIP_EML_Mouse0.71504945
96KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.71248668
97ELF1_20517297_ChIP-Seq_JURKAT_Human0.70898776
98CTCF_21964334_ChIP-Seq_BJAB-B_Human0.68011756
99CTCF_21964334_Chip-Seq_Bcells_Human0.67186282
100GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.65062635

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology6.45268154
2MP0000685_abnormal_immune_system3.70364313
3MP0005671_abnormal_response_to3.68294410
4MP0000703_abnormal_thymus_morphology3.27257512
5MP0009333_abnormal_splenocyte_physiolog3.14635292
6MP0002166_altered_tumor_susceptibility3.08576243
7MP0001800_abnormal_humoral_immune3.03181392
8MP0002398_abnormal_bone_marrow3.02447658
9MP0001835_abnormal_antigen_presentation2.79226405
10MP0001790_abnormal_immune_system2.72920874
11MP0005387_immune_system_phenotype2.72920874
12MP0002420_abnormal_adaptive_immunity2.71414647
13MP0002396_abnormal_hematopoietic_system2.70955626
14MP0001819_abnormal_immune_cell2.66102200
15MP0003300_gastrointestinal_ulcer2.65614376
16MP0005000_abnormal_immune_tolerance2.65494233
17MP0002723_abnormal_immune_serum2.64214958
18MP0002722_abnormal_immune_system2.53815887
19MP0000716_abnormal_immune_system2.52430819
20MP0002405_respiratory_system_inflammati2.45949139
21MP0003436_decreased_susceptibility_to2.45712550
22MP0002006_tumorigenesis2.44697271
23MP0000689_abnormal_spleen_morphology2.38082760
24MP0002452_abnormal_antigen_presenting2.36571606
25MP0003866_abnormal_defecation2.33198156
26MP0001873_stomach_inflammation2.16773457
27MP0002429_abnormal_blood_cell2.09847519
28MP0005025_abnormal_response_to2.08617823
29MP0010155_abnormal_intestine_physiology2.05742430
30MP0006082_CNS_inflammation2.02479476
31MP0003303_peritoneal_inflammation2.01109055
32MP0004947_skin_inflammation1.99002109
33MP0004808_abnormal_hematopoietic_stem1.98635851
34MP0003724_increased_susceptibility_to1.88615468
35MP0009785_altered_susceptibility_to1.84537988
36MP0002933_joint_inflammation1.78694130
37MP0004510_myositis1.73981701
38MP0010352_gastrointestinal_tract_polyps1.68518048
39MP0005464_abnormal_platelet_physiology1.60290470
40MP0001845_abnormal_inflammatory_respons1.57868833
41MP0008961_abnormal_basal_metabolism1.45347349
42MP0004381_abnormal_hair_follicle1.44199686
43MP0002419_abnormal_innate_immunity1.43092329
44MP0001853_heart_inflammation1.41402955
45MP0002148_abnormal_hypersensitivity_rea1.41210070
46MP0000465_gastrointestinal_hemorrhage1.34188830
47MP0010094_abnormal_chromosome_stability1.28081008
48MP0000490_abnormal_crypts_of1.23500679
49MP0005310_abnormal_salivary_gland1.21521402
50MP0008057_abnormal_DNA_replication1.18149293
51MP0001545_abnormal_hematopoietic_system1.17437808
52MP0005397_hematopoietic_system_phenotyp1.17437808
53MP0003077_abnormal_cell_cycle1.15113288
54MP0002019_abnormal_tumor_incidence1.14644617
55MP0000858_altered_metastatic_potential1.14122078
56MP0002009_preneoplasia1.10312492
57MP0004957_abnormal_blastocyst_morpholog0.99286137
58MP0009278_abnormal_bone_marrow0.98612292
59MP0005076_abnormal_cell_differentiation0.98335981
60MP0005075_abnormal_melanosome_morpholog0.94673861
61MP0003111_abnormal_nucleus_morphology0.92504794
62MP0003448_altered_tumor_morphology0.92024210
63MP0003693_abnormal_embryo_hatching0.90540527
64MP0001533_abnormal_skeleton_physiology0.90058039
65MP0005023_abnormal_wound_healing0.84987074
66MP0002138_abnormal_hepatobiliary_system0.83363809
67MP0008469_abnormal_protein_level0.81845490
68MP0001851_eye_inflammation0.79812128
69MP0009765_abnormal_xenobiotic_induced0.75813415
70MP0002132_abnormal_respiratory_system0.75453677
71MP0004185_abnormal_adipocyte_glucose0.74915266
72MP0000350_abnormal_cell_proliferation0.73410426
73MP0000609_abnormal_liver_physiology0.72551255
74MP0001348_abnormal_lacrimal_gland0.68943629
75MP0001730_embryonic_growth_arrest0.67912688
76MP0005174_abnormal_tail_pigmentation0.65315462
77MP0002998_abnormal_bone_remodeling0.65204434
78MP0002822_catalepsy0.63360638
79MP0000477_abnormal_intestine_morphology0.62584330
80MP0001243_abnormal_dermal_layer0.59566270
81MP0000313_abnormal_cell_death0.58686225
82MP0009763_increased_sensitivity_to0.57613388
83MP0003656_abnormal_erythrocyte_physiolo0.55854605
84MP0005451_abnormal_body_composition0.55518076
85MP0003795_abnormal_bone_structure0.54920059
86MP0010307_abnormal_tumor_latency0.53075570
87MP0008873_increased_physiological_sensi0.52815668
88MP0003787_abnormal_imprinting0.52271428
89MP0000604_amyloidosis0.49731119
90MP0002970_abnormal_white_adipose0.48931437
91MP0008770_decreased_survivor_rate0.48715291
92MP0002083_premature_death0.46071019
93MP0001663_abnormal_digestive_system0.45086565
94MP0001216_abnormal_epidermal_layer0.44066025
95MP0008007_abnormal_cellular_replicative0.43847202
96MP0001191_abnormal_skin_condition0.43033644
97MP0002136_abnormal_kidney_physiology0.42783334
98MP0009931_abnormal_skin_appearance0.42577915
99MP0008058_abnormal_DNA_repair0.40970054
100MP0003045_fibrosis0.40627661

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)8.33691620
2Abnormality of T cell number (HP:0011839)7.95273600
3Severe combined immunodeficiency (HP:0004430)5.60827038
4Abnormality of T cells (HP:0002843)5.48287280
5Combined immunodeficiency (HP:0005387)5.47660490
6B lymphocytopenia (HP:0010976)5.27235622
7Abnormality of B cell number (HP:0010975)5.27235622
8Elevated erythrocyte sedimentation rate (HP:0003565)5.23736501
9Panhypogammaglobulinemia (HP:0003139)5.12995822
10Recurrent viral infections (HP:0004429)4.87482602
11Stomatitis (HP:0010280)4.73457007
12Recurrent fungal infections (HP:0002841)4.42057984
13Eosinophilia (HP:0001880)4.38591788
14Abnormality of the fingertips (HP:0001211)4.30433981
15IgG deficiency (HP:0004315)4.28817953
16Recurrent bronchitis (HP:0002837)4.25346778
17Nasal polyposis (HP:0100582)4.17488199
18Chronic otitis media (HP:0000389)4.12511670
19Abnormal delayed hypersensitivity skin test (HP:0002963)4.07342167
20Abnormality of eosinophils (HP:0001879)3.89887511
21Granulocytopenia (HP:0001913)3.73268964
22IgM deficiency (HP:0002850)3.70045049
23Pustule (HP:0200039)3.58912599
24Abnormality of the nasal mucosa (HP:0000433)3.50495725
25Autoimmune hemolytic anemia (HP:0001890)3.43057097
26Basal cell carcinoma (HP:0002671)3.38982992
27Leukocytosis (HP:0001974)3.38472909
28Increased IgM level (HP:0003496)3.36738491
29Thyroiditis (HP:0100646)3.31731924
30Hypoplasia of the thymus (HP:0000778)3.28958014
31Eczematoid dermatitis (HP:0000976)3.22578117
32Chronic mucocutaneous candidiasis (HP:0002728)3.21292167
33Recurrent cutaneous fungal infections (HP:0011370)3.21292167
34Lymphopenia (HP:0001888)3.16502364
35Abnormality of T cell physiology (HP:0011840)3.13112511
36Abnormality of cells of the lymphoid lineage (HP:0012140)3.09625753
37Autoimmune thrombocytopenia (HP:0001973)3.09251345
38Joint swelling (HP:0001386)3.02594752
39Spontaneous hematomas (HP:0007420)3.00179588
40Verrucae (HP:0200043)2.87295663
41Papilloma (HP:0012740)2.87295663
42Thrombocytosis (HP:0001894)2.79732774
43Chronic diarrhea (HP:0002028)2.76909374
44Lymphoma (HP:0002665)2.72692700
45Increased IgE level (HP:0003212)2.63033930
46Hypergammaglobulinemia (HP:0010702)2.50790435
47Abnormal platelet volume (HP:0011876)2.45119548
48Abnormality of cells of the erythroid lineage (HP:0012130)2.43101566
49Gastrointestinal inflammation (HP:0004386)2.41400465
50IgA deficiency (HP:0002720)2.40298349
51Inflammation of the large intestine (HP:0002037)2.39998318
52Meningitis (HP:0001287)2.37736596
53Bronchitis (HP:0012387)2.36624226
54Abnormal number of erythroid precursors (HP:0012131)2.25943223
55Chronic sinusitis (HP:0011109)2.21008001
56Aplasia/Hypoplasia of the thymus (HP:0010515)2.19093625
57Myositis (HP:0100614)2.16551163
58Persistence of primary teeth (HP:0006335)2.14159261
59Hypochromic anemia (HP:0001931)2.10531880
60Gastrointestinal infarctions (HP:0005244)2.10250052
61Increased density of long bones (HP:0006392)2.09043372
62Encephalitis (HP:0002383)2.08390957
63Amyotrophic lateral sclerosis (HP:0007354)2.07261147
64Recurrent otitis media (HP:0000403)2.02648273
65Bicuspid aortic valve (HP:0001647)2.00693053
66Vasculitis (HP:0002633)2.00318277
67Chest pain (HP:0100749)1.95928184
68Increased mean platelet volume (HP:0011877)1.91305033
69Epistaxis (HP:0000421)1.90253460
70Recurrent sinusitis (HP:0011108)1.90235752
71Broad palm (HP:0001169)1.89582534
72Amaurosis fugax (HP:0100576)1.87768444
73Mediastinal lymphadenopathy (HP:0100721)1.86981778
74Hepatitis (HP:0012115)1.86867576
75Reticulocytopenia (HP:0001896)1.85070315
76Cellular immunodeficiency (HP:0005374)1.83381876
77Acute myeloid leukemia (HP:0004808)1.83197050
78Gingival bleeding (HP:0000225)1.82924850
79Prolonged bleeding time (HP:0003010)1.82778494
80Abnormality of oral frenula (HP:0000190)1.81295700
81Volvulus (HP:0002580)1.80441270
82Hemoptysis (HP:0002105)1.80059674
83Poikiloderma (HP:0001029)1.79577871
84Obstructive lung disease (HP:0006536)1.77339013
85Chronic obstructive pulmonary disease (HP:0006510)1.77339013
86Abnormality of the thymus (HP:0000777)1.77177637
87Agammaglobulinemia (HP:0004432)1.75850285
88Microcytic anemia (HP:0001935)1.75758551
89Hyperacusis (HP:0010780)1.74081844
90Recurrent skin infections (HP:0001581)1.72484551
91Bronchiectasis (HP:0002110)1.71996657
92Cutis marmorata (HP:0000965)1.69481018
93Aortic aneurysm (HP:0004942)1.67776116
94Macrocytic anemia (HP:0001972)1.67626174
95Prominent nose (HP:0000448)1.66819408
96Cheilitis (HP:0100825)1.65935778
97Teleangiectasia of the skin (HP:0100585)1.65860712
98Trigonocephaly (HP:0000243)1.61770667
99Seborrheic dermatitis (HP:0001051)1.61149570
100Dislocated radial head (HP:0003083)1.60665037

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K16.22886713
2TXK5.17163300
3ZAP703.33706295
4EEF2K3.25137129
5GRK62.97068039
6ITK2.84108919
7STK102.80603929
8JAK32.77396637
9FGFR42.64929404
10PKN22.40685020
11MAP3K102.36582469
12TYK22.32456268
13IKBKE1.96875265
14NLK1.93584548
15FGFR31.88163528
16LCK1.80428472
17NME21.68237828
18TRIB31.64265814
19MST41.63864593
20SYK1.56195482
21CSK1.51310963
22CDK121.48407243
23JAK11.44900693
24MAP3K141.44593874
25PRKCH1.41919387
26LRRK21.39172060
27HCK1.37433378
28PRKCQ1.25743746
29CLK11.20841063
30BTK1.16939240
31MAP3K131.16328313
32MAP3K71.15703389
33TEC1.14674948
34CDC71.13319016
35PASK1.12890344
36TBK11.04805268
37MARK31.02933422
38RPS6KA40.97405843
39PIM10.93877696
40SIK20.93748623
41JAK20.92442784
42CDK40.88359387
43TNK20.88263049
44ALK0.85663695
45PDGFRB0.81906482
46EPHB10.81857213
47IKBKB0.78863731
48PTK60.77959058
49BLK0.76733255
50TAOK10.74833213
51TESK20.72682510
52TYRO30.72641912
53FLT30.70753489
54MELK0.67470997
55FES0.66833010
56FGFR10.66026099
57TGFBR10.65383620
58CHUK0.65208611
59MARK20.64102994
60HIPK20.63456869
61RPS6KB20.62561542
62PDK10.61710401
63BRD40.60075892
64LYN0.59333891
65CSF1R0.58246228
66STK40.55419792
67KDR0.55207839
68MAP2K30.54413564
69FGFR20.52305295
70MAPK70.50727530
71TGFBR20.49765178
72INSR0.46914177
73TTN0.44798539
74MAPK110.43360547
75MAP3K80.43276575
76CDK60.42974209
77KIT0.42483550
78FYN0.41623655
79MAPK120.41124995
80CDK90.38099958
81PRKD20.37822661
82NEK20.33430948
83SIK10.32559733
84MAPK40.31076175
85NTRK20.28963229
86MAPK30.28868179
87EPHA30.28383364
88CHEK10.28269364
89RET0.28246428
90TSSK60.28080605
91EGFR0.28071633
92ATR0.27278222
93SGK30.26969088
94RPS6KA60.26303401
95CSNK1D0.25306460
96RPS6KA50.24488884
97SCYL20.22193076
98PRPF4B0.22042543
99MAP3K110.21695304
100RAF10.20770466

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.98479043
2T cell receptor signaling pathway_Homo sapiens_hsa046604.49659369
3Measles_Homo sapiens_hsa051622.78125712
4Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.76075331
5NF-kappa B signaling pathway_Homo sapiens_hsa040642.50369454
6Intestinal immune network for IgA production_Homo sapiens_hsa046722.35563935
7Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.15318406
8Acute myeloid leukemia_Homo sapiens_hsa052212.01383755
9Ribosome_Homo sapiens_hsa030101.98843065
10Hematopoietic cell lineage_Homo sapiens_hsa046401.95197319
11Antigen processing and presentation_Homo sapiens_hsa046121.95012986
12Osteoclast differentiation_Homo sapiens_hsa043801.88696827
13B cell receptor signaling pathway_Homo sapiens_hsa046621.75596324
14Viral myocarditis_Homo sapiens_hsa054161.68849243
15Allograft rejection_Homo sapiens_hsa053301.59917048
16Jak-STAT signaling pathway_Homo sapiens_hsa046301.56083633
17Leishmaniasis_Homo sapiens_hsa051401.51485356
18Herpes simplex infection_Homo sapiens_hsa051681.51169493
19Non-homologous end-joining_Homo sapiens_hsa034501.49991769
20Chronic myeloid leukemia_Homo sapiens_hsa052201.49715007
21Hepatitis B_Homo sapiens_hsa051611.48741746
22DNA replication_Homo sapiens_hsa030301.46865252
23Colorectal cancer_Homo sapiens_hsa052101.44986901
24HTLV-I infection_Homo sapiens_hsa051661.42404935
25Leukocyte transendothelial migration_Homo sapiens_hsa046701.41121343
26Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.40423614
27RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.38155871
28Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.36668267
29Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.35116529
30Chemokine signaling pathway_Homo sapiens_hsa040621.34106308
31Graft-versus-host disease_Homo sapiens_hsa053321.27449860
32Toxoplasmosis_Homo sapiens_hsa051451.23545533
33Mismatch repair_Homo sapiens_hsa034301.19390885
34Pancreatic cancer_Homo sapiens_hsa052121.18296660
35Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.16985196
36Spliceosome_Homo sapiens_hsa030401.16813932
37Autoimmune thyroid disease_Homo sapiens_hsa053201.14877545
38Thyroid cancer_Homo sapiens_hsa052161.14131618
39Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.08072151
40Shigellosis_Homo sapiens_hsa051311.03549488
41Influenza A_Homo sapiens_hsa051641.02108679
42Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.00987827
43Non-small cell lung cancer_Homo sapiens_hsa052230.99552517
44Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.99012350
45Prolactin signaling pathway_Homo sapiens_hsa049170.97830382
46NOD-like receptor signaling pathway_Homo sapiens_hsa046210.95651972
47Viral carcinogenesis_Homo sapiens_hsa052030.95442251
48Base excision repair_Homo sapiens_hsa034100.95007033
49Platelet activation_Homo sapiens_hsa046110.94746759
50Apoptosis_Homo sapiens_hsa042100.90217098
51AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.89884511
52Epstein-Barr virus infection_Homo sapiens_hsa051690.88959946
53Endometrial cancer_Homo sapiens_hsa052130.88468575
54Type I diabetes mellitus_Homo sapiens_hsa049400.85911052
55VEGF signaling pathway_Homo sapiens_hsa043700.84316280
56Hepatitis C_Homo sapiens_hsa051600.82118300
57Toll-like receptor signaling pathway_Homo sapiens_hsa046200.81242640
58One carbon pool by folate_Homo sapiens_hsa006700.80194502
59TNF signaling pathway_Homo sapiens_hsa046680.80140392
60Cyanoamino acid metabolism_Homo sapiens_hsa004600.78335765
61Neurotrophin signaling pathway_Homo sapiens_hsa047220.76560599
62Prostate cancer_Homo sapiens_hsa052150.73196724
63mRNA surveillance pathway_Homo sapiens_hsa030150.73094805
64Phosphatidylinositol signaling system_Homo sapiens_hsa040700.70572901
65Small cell lung cancer_Homo sapiens_hsa052220.69437043
66Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.68212891
67Cell cycle_Homo sapiens_hsa041100.66591327
68Legionellosis_Homo sapiens_hsa051340.63038642
69Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.60934035
70mTOR signaling pathway_Homo sapiens_hsa041500.59392484
71Asthma_Homo sapiens_hsa053100.58418188
72RNA transport_Homo sapiens_hsa030130.57740722
73FoxO signaling pathway_Homo sapiens_hsa040680.56414798
74Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.55835158
75Notch signaling pathway_Homo sapiens_hsa043300.54878270
76Transcriptional misregulation in cancer_Homo sapiens_hsa052020.54220183
77Lysine degradation_Homo sapiens_hsa003100.53921765
78Insulin resistance_Homo sapiens_hsa049310.53137454
79MAPK signaling pathway_Homo sapiens_hsa040100.52126514
80Renal cell carcinoma_Homo sapiens_hsa052110.50423757
81Thyroid hormone signaling pathway_Homo sapiens_hsa049190.49622478
82p53 signaling pathway_Homo sapiens_hsa041150.49612278
83Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.46298001
84Staphylococcus aureus infection_Homo sapiens_hsa051500.45229858
85RNA degradation_Homo sapiens_hsa030180.45122284
86Tuberculosis_Homo sapiens_hsa051520.41819056
87Salmonella infection_Homo sapiens_hsa051320.40282880
88Rap1 signaling pathway_Homo sapiens_hsa040150.39492037
89Pertussis_Homo sapiens_hsa051330.38768612
90MicroRNAs in cancer_Homo sapiens_hsa052060.38530060
91Endocytosis_Homo sapiens_hsa041440.38410481
92Regulation of actin cytoskeleton_Homo sapiens_hsa048100.37174525
93Adherens junction_Homo sapiens_hsa045200.36680890
94Dorso-ventral axis formation_Homo sapiens_hsa043200.36325988
95Pathways in cancer_Homo sapiens_hsa052000.35590437
96Adipocytokine signaling pathway_Homo sapiens_hsa049200.35551429
97Carbohydrate digestion and absorption_Homo sapiens_hsa049730.34487850
98Nucleotide excision repair_Homo sapiens_hsa034200.34244405
99Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.33787671
100Choline metabolism in cancer_Homo sapiens_hsa052310.33463502

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