TRBV17

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative T cell selection (GO:0043383)8.40733352
2positive regulation of gamma-delta T cell activation (GO:0046645)8.36037589
3negative thymic T cell selection (GO:0045060)7.75367181
4regulation of gamma-delta T cell differentiation (GO:0045586)7.35757246
5positive T cell selection (GO:0043368)7.33750709
6antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)7.31455534
7antigen processing and presentation of endogenous peptide antigen (GO:0002483)7.31455534
8negative regulation of leukocyte mediated cytotoxicity (GO:0001911)7.04390130
9negative regulation of cell killing (GO:0031342)7.04390130
10positive thymic T cell selection (GO:0045059)7.02104977
11thymic T cell selection (GO:0045061)6.61256616
12positive regulation of interleukin-2 biosynthetic process (GO:0045086)6.59980042
13T cell selection (GO:0045058)6.58542572
14regulation of gamma-delta T cell activation (GO:0046643)6.57456134
15positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)6.55878650
16regulation of isotype switching to IgG isotypes (GO:0048302)6.18337221
17antigen processing and presentation of endogenous antigen (GO:0019883)6.03647461
18interferon-gamma production (GO:0032609)5.93545839
19response to interleukin-15 (GO:0070672)5.73956861
20T cell receptor signaling pathway (GO:0050852)5.62000161
21regulation of T cell tolerance induction (GO:0002664)5.39284471
22cellular response to interleukin-15 (GO:0071350)5.20925380
23T cell costimulation (GO:0031295)4.99924651
24T cell migration (GO:0072678)4.99386303
25lymphocyte costimulation (GO:0031294)4.93566160
26activated T cell proliferation (GO:0050798)4.83275810
27leukocyte aggregation (GO:0070486)4.75255483
28regulation of interleukin-2 biosynthetic process (GO:0045076)4.70841098
29regulation of regulatory T cell differentiation (GO:0045589)4.66869826
30antigen receptor-mediated signaling pathway (GO:0050851)4.60092210
31positive regulation of interleukin-2 production (GO:0032743)4.46534072
32regulation of alpha-beta T cell proliferation (GO:0046640)4.44308972
33regulation of T cell receptor signaling pathway (GO:0050856)4.41978099
34positive regulation of tolerance induction (GO:0002645)4.40274066
35regulation of antigen receptor-mediated signaling pathway (GO:0050854)4.20632894
36negative regulation of T cell mediated immunity (GO:0002710)4.17424262
37mast cell activation (GO:0045576)4.14926188
38regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.13429796
39positive regulation of alpha-beta T cell proliferation (GO:0046641)4.09078603
40regulation of interleukin-12 biosynthetic process (GO:0045075)4.08749711
41V(D)J recombination (GO:0033151)4.02681036
42T cell differentiation (GO:0030217)3.98108548
43positive regulation of isotype switching (GO:0045830)3.97252232
44regulation of isotype switching (GO:0045191)3.95705500
45alpha-beta T cell differentiation (GO:0046632)3.88687223
46alpha-beta T cell activation (GO:0046631)3.88232065
47regulation of B cell receptor signaling pathway (GO:0050855)3.85500020
48ribosomal small subunit assembly (GO:0000028)3.82116078
49regulation of tolerance induction (GO:0002643)3.80485734
50viral transcription (GO:0019083)3.79825193
51positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.67836423
52positive regulation of natural killer cell mediated immunity (GO:0002717)3.67836423
53regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.67572724
54regulation of natural killer cell mediated immunity (GO:0002715)3.67572724
55T cell homeostasis (GO:0043029)3.65025503
56tolerance induction (GO:0002507)3.61870211
57positive regulation of humoral immune response (GO:0002922)3.61284285
58translational termination (GO:0006415)3.58544568
59positive regulation of immunoglobulin mediated immune response (GO:0002891)3.48348369
60positive regulation of B cell mediated immunity (GO:0002714)3.48348369
61regulation of immunoglobulin mediated immune response (GO:0002889)3.47503647
62regulation of B cell mediated immunity (GO:0002712)3.45062818
63regulation of interleukin-2 production (GO:0032663)3.41768721
64T cell activation (GO:0042110)3.40947398
65regulation of defense response to virus by virus (GO:0050690)3.39904411
66regulation of response to interferon-gamma (GO:0060330)3.39857118
67negative regulation of T cell receptor signaling pathway (GO:0050860)3.39766528
68negative regulation of lymphocyte mediated immunity (GO:0002707)3.38416180
69ribosomal small subunit biogenesis (GO:0042274)3.35441195
70positive regulation of DNA recombination (GO:0045911)3.35425914
71regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.33069827
72regulation of B cell differentiation (GO:0045577)3.32730900
73negative regulation of erythrocyte differentiation (GO:0045647)3.32485005
74positive regulation of B cell differentiation (GO:0045579)3.31545594
75cellular response to interleukin-4 (GO:0071353)3.28914264
76mast cell activation involved in immune response (GO:0002279)3.26611385
77mast cell degranulation (GO:0043303)3.26611385
78regulation of immunoglobulin production (GO:0002637)3.26127013
79NIK/NF-kappaB signaling (GO:0038061)3.25895388
80antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.14637286
81leukocyte cell-cell adhesion (GO:0007159)3.13828968
82immune response-activating cell surface receptor signaling pathway (GO:0002429)3.12736922
83regulation of leukocyte mediated cytotoxicity (GO:0001910)3.12687957
84antigen processing and presentation via MHC class Ib (GO:0002475)3.11164762
85negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.10750552
86positive regulation of granulocyte differentiation (GO:0030854)3.09477256
87CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.09073620
88positive regulation of immunoglobulin production (GO:0002639)3.08412467
89translational elongation (GO:0006414)3.08342220
90positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.08255497
91JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.06207266
92positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.05532434
93lymphocyte homeostasis (GO:0002260)3.04812745
94response to interleukin-4 (GO:0070670)3.04068668
95T cell proliferation (GO:0042098)3.03312377
96positive regulation of T cell activation (GO:0050870)3.00512401
97nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.98440596
98natural killer cell differentiation (GO:0001779)2.96401570
99regulation of type I interferon-mediated signaling pathway (GO:0060338)2.92218409
100natural killer cell activation (GO:0030101)2.91401531

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse7.79314243
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.89077329
3E2F7_22180533_ChIP-Seq_HELA_Human4.66339992
4MYC_22102868_ChIP-Seq_BL_Human3.94200738
5RUNX_20019798_ChIP-Seq_JUKART_Human3.71903971
6FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.60581543
7STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.43156847
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.33269872
9MYB_26560356_Chip-Seq_TH2_Human3.21642675
10STAT4_19710469_ChIP-ChIP_TH1__Mouse3.10241792
11IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.00897371
12IRF8_22096565_ChIP-ChIP_GC-B_Human2.99879010
13MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.99560296
14MAF_26560356_Chip-Seq_TH1_Human2.88297729
15UTX_26944678_Chip-Seq_JUKART_Human2.79338312
16MYB_26560356_Chip-Seq_TH1_Human2.65101336
17EGR1_19374776_ChIP-ChIP_THP-1_Human2.57953687
18VDR_21846776_ChIP-Seq_THP-1_Human2.45897287
19SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.44099275
20NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.36588623
21RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.26363823
22SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.25853264
23MAF_26560356_Chip-Seq_TH2_Human2.20162749
24KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.19093922
25NOTCH1_21737748_ChIP-Seq_TLL_Human2.10919797
26GATA3_27048872_Chip-Seq_THYMUS_Human2.09795979
27TCF7_22412390_ChIP-Seq_EML_Mouse2.06626299
28EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.06485817
29ELF1_17652178_ChIP-ChIP_JURKAT_Human1.96976054
30RUNX1_22412390_ChIP-Seq_EML_Mouse1.95940430
31KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.88363826
32MYB_21317192_ChIP-Seq_ERMYB_Mouse1.84830107
33SCL_19346495_ChIP-Seq_HPC-7_Human1.83163304
34KDM2B_26808549_Chip-Seq_DND41_Human1.82143329
35TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.82079421
36FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.81241890
37ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.79067119
38CIITA_25753668_ChIP-Seq_RAJI_Human1.76738624
39E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.74972416
40SPI1_23547873_ChIP-Seq_NB4_Human1.72086060
41VDR_24763502_ChIP-Seq_THP-1_Human1.70767058
42NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.65352246
43SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.58305784
44MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.45091256
45BRD4_27068464_Chip-Seq_AML-cells_Mouse1.44439912
46RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.40755545
47IRF8_21731497_ChIP-ChIP_J774_Mouse1.40104637
48BP1_19119308_ChIP-ChIP_Hs578T_Human1.39981028
49SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.37123359
50VDR_23849224_ChIP-Seq_CD4+_Human1.35394980
51FOXM1_23109430_ChIP-Seq_U2OS_Human1.32614835
52FOXP3_21729870_ChIP-Seq_TREG_Human1.32311750
53IRF8_27001747_Chip-Seq_BMDM_Mouse1.31017516
54SPI1_23127762_ChIP-Seq_K562_Human1.30530649
55KDM2B_26808549_Chip-Seq_SUP-B15_Human1.29611164
56GATA2_22383799_ChIP-Seq_G1ME_Mouse1.28850838
57TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.25341502
58KDM2B_26808549_Chip-Seq_JURKAT_Human1.22266181
59ERG_20887958_ChIP-Seq_HPC-7_Mouse1.15713613
60VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.13893618
61MYC_18555785_ChIP-Seq_MESCs_Mouse1.13542068
62GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.13313395
63GATA3_26560356_Chip-Seq_TH2_Human1.13044808
64ELK3_25401928_ChIP-Seq_HUVEC_Human1.12525854
65MYC_19079543_ChIP-ChIP_MESCs_Mouse1.10639119
66XRN2_22483619_ChIP-Seq_HELA_Human1.06448581
67E2F4_17652178_ChIP-ChIP_JURKAT_Human1.05835771
68RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.05783847
69TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05690747
70PU_27001747_Chip-Seq_BMDM_Mouse1.05177678
71GATA1_22383799_ChIP-Seq_G1ME_Mouse1.04329186
72HOXB4_20404135_ChIP-ChIP_EML_Mouse1.00872548
73ELK1_19687146_ChIP-ChIP_HELA_Human0.99388177
74LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.97939419
75FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.97353700
76BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.96275132
77CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95617261
78NCOR1_26117541_ChIP-Seq_K562_Human0.91359585
79PU.1_20513432_ChIP-Seq_Bcells_Mouse0.88826291
80EST1_17652178_ChIP-ChIP_JURKAT_Human0.87801307
81SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.87795432
82CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.87513879
83RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87243421
84GATA1_19941827_ChIP-Seq_MEL_Mouse0.86655618
85FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84476603
86LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.83289293
87PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.82291159
88KDM5A_27292631_Chip-Seq_BREAST_Human0.80887665
89FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.80638527
90GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.77528233
91CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.76514382
92DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.75694027
93NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.75342035
94FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.73101240
95GABP_17652178_ChIP-ChIP_JURKAT_Human0.70923592
96PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.69031448
97GATA1_19941826_ChIP-Seq_K562_Human0.66858868
98CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.65674259
99ELF1_20517297_ChIP-Seq_JURKAT_Human0.65523078
100ETS1_22383799_ChIP-Seq_G1ME_Mouse0.64368684

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology6.35791694
2MP0005671_abnormal_response_to4.27008544
3MP0000685_abnormal_immune_system3.69505225
4MP0002166_altered_tumor_susceptibility3.16096375
5MP0000703_abnormal_thymus_morphology3.10183601
6MP0009333_abnormal_splenocyte_physiolog3.03701652
7MP0001800_abnormal_humoral_immune3.01325403
8MP0002398_abnormal_bone_marrow2.99354812
9MP0001835_abnormal_antigen_presentation2.98164067
10MP0002420_abnormal_adaptive_immunity2.74911806
11MP0005000_abnormal_immune_tolerance2.70576872
12MP0001819_abnormal_immune_cell2.70298525
13MP0003300_gastrointestinal_ulcer2.67050625
14MP0002723_abnormal_immune_serum2.64260500
15MP0001790_abnormal_immune_system2.61545822
16MP0005387_immune_system_phenotype2.61545822
17MP0002006_tumorigenesis2.59985715
18MP0002396_abnormal_hematopoietic_system2.56058213
19MP0000716_abnormal_immune_system2.53295144
20MP0002405_respiratory_system_inflammati2.48011190
21MP0002722_abnormal_immune_system2.46505963
22MP0001873_stomach_inflammation2.41825637
23MP0002452_abnormal_antigen_presenting2.36844822
24MP0003866_abnormal_defecation2.35278955
25MP0000689_abnormal_spleen_morphology2.33326888
26MP0003724_increased_susceptibility_to2.27354861
27MP0010155_abnormal_intestine_physiology2.23686785
28MP0009785_altered_susceptibility_to2.20581667
29MP0005025_abnormal_response_to2.18408834
30MP0003436_decreased_susceptibility_to2.18028548
31MP0003303_peritoneal_inflammation2.10233340
32MP0002429_abnormal_blood_cell2.08537706
33MP0004947_skin_inflammation2.07679451
34MP0006082_CNS_inflammation2.01557282
35MP0001853_heart_inflammation1.81086113
36MP0002933_joint_inflammation1.77398514
37MP0002132_abnormal_respiratory_system1.74022481
38MP0005464_abnormal_platelet_physiology1.67066315
39MP0004808_abnormal_hematopoietic_stem1.64283128
40MP0001545_abnormal_hematopoietic_system1.63509448
41MP0005397_hematopoietic_system_phenotyp1.63509448
42MP0001845_abnormal_inflammatory_respons1.57919506
43MP0002419_abnormal_innate_immunity1.57161376
44MP0004381_abnormal_hair_follicle1.56640749
45MP0002148_abnormal_hypersensitivity_rea1.56632248
46MP0000490_abnormal_crypts_of1.43456793
47MP0000465_gastrointestinal_hemorrhage1.42794330
48MP0005075_abnormal_melanosome_morpholog1.41802345
49MP0004510_myositis1.36085080
50MP0008961_abnormal_basal_metabolism1.34021686
51MP0000858_altered_metastatic_potential1.31221682
52MP0010352_gastrointestinal_tract_polyps1.28206672
53MP0008057_abnormal_DNA_replication1.18840040
54MP0005310_abnormal_salivary_gland1.13216933
55MP0002019_abnormal_tumor_incidence1.11892111
56MP0003077_abnormal_cell_cycle0.97124105
57MP0001533_abnormal_skeleton_physiology0.96185266
58MP0010094_abnormal_chromosome_stability0.94985065
59MP0008469_abnormal_protein_level0.94641418
60MP0002009_preneoplasia0.93422811
61MP0003448_altered_tumor_morphology0.85892977
62MP0003693_abnormal_embryo_hatching0.84229849
63MP0002138_abnormal_hepatobiliary_system0.82829542
64MP0005023_abnormal_wound_healing0.82788601
65MP0009278_abnormal_bone_marrow0.81055553
66MP0004957_abnormal_blastocyst_morpholog0.77594447
67MP0001348_abnormal_lacrimal_gland0.76909174
68MP0001851_eye_inflammation0.76449230
69MP0009765_abnormal_xenobiotic_induced0.73058716
70MP0002998_abnormal_bone_remodeling0.71934222
71MP0001663_abnormal_digestive_system0.71247877
72MP0008007_abnormal_cellular_replicative0.70428195
73MP0000609_abnormal_liver_physiology0.69635552
74MP0005174_abnormal_tail_pigmentation0.68325443
75MP0009763_increased_sensitivity_to0.68159617
76MP0000477_abnormal_intestine_morphology0.64346153
77MP0001243_abnormal_dermal_layer0.60384125
78MP0000350_abnormal_cell_proliferation0.59951391
79MP0003795_abnormal_bone_structure0.59399242
80MP0000313_abnormal_cell_death0.53245128
81MP0004185_abnormal_adipocyte_glucose0.49649141
82MP0008770_decreased_survivor_rate0.47434258
83MP0003111_abnormal_nucleus_morphology0.46568777
84MP0008873_increased_physiological_sensi0.45884845
85MP0002822_catalepsy0.42240197
86MP0000604_amyloidosis0.42184672
87MP0002095_abnormal_skin_pigmentation0.40992928
88MP0001191_abnormal_skin_condition0.40890993
89MP0001730_embryonic_growth_arrest0.39938637
90MP0000367_abnormal_coat/_hair0.39851879
91MP0003453_abnormal_keratinocyte_physiol0.39537084
92MP0001216_abnormal_epidermal_layer0.39488985
93MP0002083_premature_death0.38884880
94MP0002136_abnormal_kidney_physiology0.36457789
95MP0002970_abnormal_white_adipose0.36239746
96MP0003045_fibrosis0.36105875
97MP0008569_lethality_at_weaning0.35633705
98MP0003959_abnormal_lean_body0.35395621
99MP0002693_abnormal_pancreas_physiology0.33787878
100MP0009764_decreased_sensitivity_to0.33287337

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)8.85609045
2Abnormality of T cell number (HP:0011839)8.43599387
3Severe combined immunodeficiency (HP:0004430)5.66997061
4Abnormality of T cells (HP:0002843)5.63110984
5Elevated erythrocyte sedimentation rate (HP:0003565)5.43273690
6Combined immunodeficiency (HP:0005387)5.41307670
7Chronic otitis media (HP:0000389)5.36278955
8Panhypogammaglobulinemia (HP:0003139)5.32008139
9Recurrent viral infections (HP:0004429)5.20931489
10Stomatitis (HP:0010280)4.80699669
11Recurrent bronchitis (HP:0002837)4.64427822
12Nasal polyposis (HP:0100582)4.63791133
13Recurrent fungal infections (HP:0002841)4.59187182
14Eosinophilia (HP:0001880)4.34294897
15Abnormality of B cell number (HP:0010975)4.28169465
16B lymphocytopenia (HP:0010976)4.28169465
17IgG deficiency (HP:0004315)4.23336940
18Abnormality of eosinophils (HP:0001879)4.12797540
19Abnormality of the nasal mucosa (HP:0000433)3.90606262
20Abnormal delayed hypersensitivity skin test (HP:0002963)3.83444188
21IgM deficiency (HP:0002850)3.80240925
22Granulocytopenia (HP:0001913)3.76896620
23Abnormality of the fingertips (HP:0001211)3.76344423
24Leukocytosis (HP:0001974)3.65333582
25Hypoplasia of the thymus (HP:0000778)3.56483058
26Pustule (HP:0200039)3.48968118
27Thyroiditis (HP:0100646)3.46604997
28Autoimmune hemolytic anemia (HP:0001890)3.38908072
29Recurrent cutaneous fungal infections (HP:0011370)3.35059097
30Chronic mucocutaneous candidiasis (HP:0002728)3.35059097
31Myositis (HP:0100614)3.21928718
32Joint swelling (HP:0001386)3.18280015
33Basal cell carcinoma (HP:0002671)3.14697133
34Abnormality of T cell physiology (HP:0011840)3.12752032
35Lymphopenia (HP:0001888)3.08774430
36Spontaneous hematomas (HP:0007420)3.06891927
37Abnormality of cells of the lymphoid lineage (HP:0012140)3.03233700
38Eczematoid dermatitis (HP:0000976)2.97902063
39Abnormality of cells of the erythroid lineage (HP:0012130)2.96236355
40Chronic diarrhea (HP:0002028)2.86380708
41Abnormal number of erythroid precursors (HP:0012131)2.85993443
42Encephalitis (HP:0002383)2.82415109
43Meningitis (HP:0001287)2.82233365
44Increased IgM level (HP:0003496)2.80856170
45Thrombocytosis (HP:0001894)2.79231636
46Autoimmune thrombocytopenia (HP:0001973)2.78832071
47Lymphoma (HP:0002665)2.76486487
48Bronchitis (HP:0012387)2.66621891
49Hemoptysis (HP:0002105)2.63958817
50Gastrointestinal infarctions (HP:0005244)2.61919939
51Chronic sinusitis (HP:0011109)2.57477887
52Increased IgE level (HP:0003212)2.53061737
53Abnormal platelet volume (HP:0011876)2.49568669
54Epistaxis (HP:0000421)2.48523849
55Papilloma (HP:0012740)2.48021473
56Verrucae (HP:0200043)2.48021473
57Inflammation of the large intestine (HP:0002037)2.45511282
58Petechiae (HP:0000967)2.44525381
59Chest pain (HP:0100749)2.40353585
60Vasculitis (HP:0002633)2.40025041
61Hypergammaglobulinemia (HP:0010702)2.39754500
62Gastrointestinal inflammation (HP:0004386)2.39553905
63Prolonged bleeding time (HP:0003010)2.38042495
64Abnormality of the prostate (HP:0008775)2.32916208
65Pulmonary infiltrates (HP:0002113)2.30230250
66IgA deficiency (HP:0002720)2.29335787
67Retrobulbar optic neuritis (HP:0100654)2.28369546
68Optic neuritis (HP:0100653)2.28369546
69Ureteral stenosis (HP:0000071)2.25066551
70Mediastinal lymphadenopathy (HP:0100721)2.23379832
71Aplasia/Hypoplasia of the thymus (HP:0010515)2.21996986
72Pulmonary embolism (HP:0002204)2.15983593
73Recurrent abscess formation (HP:0002722)2.14383238
74Bicuspid aortic valve (HP:0001647)2.13094311
75Obstructive lung disease (HP:0006536)2.11510751
76Chronic obstructive pulmonary disease (HP:0006510)2.11510751
77Recurrent sinusitis (HP:0011108)2.10594908
78Hepatitis (HP:0012115)2.09869617
79Cellular immunodeficiency (HP:0005374)2.09027651
80Amaurosis fugax (HP:0100576)2.07311500
81Poikiloderma (HP:0001029)2.06863507
82Recurrent otitis media (HP:0000403)2.06847297
83Recurrent skin infections (HP:0001581)2.04952467
84Gingival bleeding (HP:0000225)2.01007035
85Ureteral obstruction (HP:0006000)2.00900684
86Orchitis (HP:0100796)1.97719201
87Increased mean platelet volume (HP:0011877)1.96891695
88Arterial thrombosis (HP:0004420)1.95652270
89Reticulocytopenia (HP:0001896)1.95160890
90Agammaglobulinemia (HP:0004432)1.94516231
91Bronchiectasis (HP:0002110)1.91027471
92Broad palm (HP:0001169)1.86438164
93Macrocytic anemia (HP:0001972)1.85442971
94Keratoconjunctivitis sicca (HP:0001097)1.82943117
95Pallor (HP:0000980)1.82850734
96Increased density of long bones (HP:0006392)1.82271346
97Fatigue (HP:0012378)1.77937183
98Abnormality of oral frenula (HP:0000190)1.77137821
99Abnormality of the thymus (HP:0000777)1.74843762
100Hypochromic anemia (HP:0001931)1.73147371

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK6.42555081
2MAP4K15.61936254
3ITK3.44023570
4JAK33.10045022
5ZAP703.08246182
6FGFR42.86406662
7STK102.70981905
8TYK22.39596999
9MAP3K102.35291463
10GRK62.29526569
11NLK2.26936329
12IKBKE2.16922068
13EEF2K2.16470938
14PKN21.90568771
15FGFR31.90007740
16TEC1.88024891
17LCK1.85415200
18MST41.70434363
19NME21.65706069
20CDK121.65346825
21JAK11.62040010
22STK161.57145427
23MAP3K141.52769616
24BTK1.46570669
25LRRK21.42917408
26CSK1.42067774
27SYK1.40989603
28HCK1.27867067
29MAP3K131.24547314
30PRKCH1.19755952
31PRKCQ1.17295440
32MAP3K71.14250232
33JAK21.09533700
34TBK11.08173915
35RPS6KA41.01869121
36ACVR1B1.00242286
37MARK30.96342014
38SCYL20.93535798
39PASK0.93135542
40IKBKB0.92911879
41PIM10.91295616
42TYRO30.90547482
43CLK10.87558383
44TRIB30.76623771
45KIT0.73905715
46CDK40.71285769
47FES0.69968845
48FLT30.68980435
49TNK20.67497516
50CHUK0.66983348
51MARK20.66092329
52TGFBR20.65136233
53PDGFRB0.63897479
54SIK20.62713491
55KDR0.62156614
56LYN0.62054655
57TGFBR10.61728199
58BLK0.61202515
59TTN0.60477429
60TESK20.58661391
61MAP2K30.58469870
62FGFR10.57828264
63FGFR20.55825156
64HIPK20.55496561
65MAPK70.55218598
66TAOK10.54632370
67EPHB10.52492232
68RPS6KB20.51455853
69IRAK40.49181402
70STK40.48852969
71ALK0.48458960
72NTRK20.48236389
73PDK10.45729568
74MELK0.42155265
75BRD40.41070443
76EPHA30.40521640
77CDK60.38932318
78MAP3K80.38214764
79INSR0.38106927
80TSSK60.36819319
81MAPK40.36749537
82FYN0.36489129
83EIF2AK10.34434465
84MAPK110.33935938
85PTK60.33293721
86MAPK120.32339668
87PIM20.32070598
88CDC70.30440259
89RPS6KA50.29607601
90CSF1R0.28540976
91RPS6KA60.27132680
92RAF10.27083246
93RET0.26363190
94ATR0.24773051
95MAP3K110.22733319
96IGF1R0.22505402
97CDK90.21813217
98ROCK20.21736982
99SGK30.21660661
100MAPK30.21415886

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053406.05447401
2T cell receptor signaling pathway_Homo sapiens_hsa046604.42873532
3Measles_Homo sapiens_hsa051622.93051501
4Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.79915262
5Intestinal immune network for IgA production_Homo sapiens_hsa046722.72495268
6Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.66614600
7NF-kappa B signaling pathway_Homo sapiens_hsa040642.52836679
8Ribosome_Homo sapiens_hsa030102.46994477
9Allograft rejection_Homo sapiens_hsa053302.31855913
10Antigen processing and presentation_Homo sapiens_hsa046122.28159989
11Hematopoietic cell lineage_Homo sapiens_hsa046402.27145201
12Autoimmune thyroid disease_Homo sapiens_hsa053202.02673466
13Graft-versus-host disease_Homo sapiens_hsa053321.92588876
14Osteoclast differentiation_Homo sapiens_hsa043801.82125047
15Viral myocarditis_Homo sapiens_hsa054161.77142883
16Leishmaniasis_Homo sapiens_hsa051401.75458688
17Jak-STAT signaling pathway_Homo sapiens_hsa046301.72828787
18Acute myeloid leukemia_Homo sapiens_hsa052211.70214480
19Non-homologous end-joining_Homo sapiens_hsa034501.68479504
20B cell receptor signaling pathway_Homo sapiens_hsa046621.60803781
21Herpes simplex infection_Homo sapiens_hsa051681.58437965
22RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.46846696
23Hepatitis B_Homo sapiens_hsa051611.40330589
24Leukocyte transendothelial migration_Homo sapiens_hsa046701.33149397
25Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.30767424
26HTLV-I infection_Homo sapiens_hsa051661.29025003
27Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.29018870
28Toxoplasmosis_Homo sapiens_hsa051451.27986552
29Colorectal cancer_Homo sapiens_hsa052101.26804721
30Chronic myeloid leukemia_Homo sapiens_hsa052201.25511836
31Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.24448054
32Chemokine signaling pathway_Homo sapiens_hsa040621.24422654
33Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.20029216
34Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.19397139
35Spliceosome_Homo sapiens_hsa030401.14942918
36Shigellosis_Homo sapiens_hsa051311.12314175
37NOD-like receptor signaling pathway_Homo sapiens_hsa046211.12288567
38Pancreatic cancer_Homo sapiens_hsa052121.06514289
39Platelet activation_Homo sapiens_hsa046111.00487365
40Influenza A_Homo sapiens_hsa051640.99952122
41Viral carcinogenesis_Homo sapiens_hsa052030.97899172
42Type I diabetes mellitus_Homo sapiens_hsa049400.97632138
43Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.93311824
44Thyroid cancer_Homo sapiens_hsa052160.92987773
45Epstein-Barr virus infection_Homo sapiens_hsa051690.91696646
46AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.90432080
47Prolactin signaling pathway_Homo sapiens_hsa049170.88893523
48TNF signaling pathway_Homo sapiens_hsa046680.88750550
49Apoptosis_Homo sapiens_hsa042100.87818696
50Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.83039310
51Non-small cell lung cancer_Homo sapiens_hsa052230.80454389
52Hepatitis C_Homo sapiens_hsa051600.79842196
53Asthma_Homo sapiens_hsa053100.79648190
54Toll-like receptor signaling pathway_Homo sapiens_hsa046200.79494517
55Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.78892041
56Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.78505335
57RNA degradation_Homo sapiens_hsa030180.74467705
58Legionellosis_Homo sapiens_hsa051340.70894182
59DNA replication_Homo sapiens_hsa030300.68158043
60Staphylococcus aureus infection_Homo sapiens_hsa051500.66915582
61p53 signaling pathway_Homo sapiens_hsa041150.66828432
62Mismatch repair_Homo sapiens_hsa034300.64917169
63Phosphatidylinositol signaling system_Homo sapiens_hsa040700.63803910
64Endometrial cancer_Homo sapiens_hsa052130.61572447
65Notch signaling pathway_Homo sapiens_hsa043300.60823040
66Small cell lung cancer_Homo sapiens_hsa052220.59322973
67VEGF signaling pathway_Homo sapiens_hsa043700.58817240
68mRNA surveillance pathway_Homo sapiens_hsa030150.57280732
69FoxO signaling pathway_Homo sapiens_hsa040680.56232721
70Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.54116458
71Transcriptional misregulation in cancer_Homo sapiens_hsa052020.53216857
72Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.53110890
73Neurotrophin signaling pathway_Homo sapiens_hsa047220.52869797
74Tuberculosis_Homo sapiens_hsa051520.52790705
75Prostate cancer_Homo sapiens_hsa052150.51791539
76RNA transport_Homo sapiens_hsa030130.50705634
77Malaria_Homo sapiens_hsa051440.46405504
78mTOR signaling pathway_Homo sapiens_hsa041500.43858376
79Thyroid hormone signaling pathway_Homo sapiens_hsa049190.40892495
80Salmonella infection_Homo sapiens_hsa051320.40296920
81Endocytosis_Homo sapiens_hsa041440.40292146
82Pertussis_Homo sapiens_hsa051330.39385894
83Regulation of actin cytoskeleton_Homo sapiens_hsa048100.38840551
84Rap1 signaling pathway_Homo sapiens_hsa040150.37131828
85Base excision repair_Homo sapiens_hsa034100.36683231
86Renal cell carcinoma_Homo sapiens_hsa052110.35881546
87Inositol phosphate metabolism_Homo sapiens_hsa005620.35844389
88MAPK signaling pathway_Homo sapiens_hsa040100.35840557
89Lysine degradation_Homo sapiens_hsa003100.34773239
90Insulin resistance_Homo sapiens_hsa049310.34654464
91Cell cycle_Homo sapiens_hsa041100.32364724
92One carbon pool by folate_Homo sapiens_hsa006700.30206795
93Pathways in cancer_Homo sapiens_hsa052000.29740854
94MicroRNAs in cancer_Homo sapiens_hsa052060.28330709
95Choline metabolism in cancer_Homo sapiens_hsa052310.27851917
96Adherens junction_Homo sapiens_hsa045200.27774672
97Dorso-ventral axis formation_Homo sapiens_hsa043200.26200987
98Adipocytokine signaling pathway_Homo sapiens_hsa049200.23908702
99HIF-1 signaling pathway_Homo sapiens_hsa040660.23846650
100Sphingolipid signaling pathway_Homo sapiens_hsa040710.22600750

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