TRBV18

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)7.80241314
2negative T cell selection (GO:0043383)7.06759742
3negative thymic T cell selection (GO:0045060)6.41744441
4negative regulation of T cell mediated immunity (GO:0002710)6.25347563
5positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)6.06771633
6antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.00295222
7regulation of gamma-delta T cell activation (GO:0046643)5.85562089
8interferon-gamma production (GO:0032609)5.77305736
9regulation of T cell tolerance induction (GO:0002664)5.66233405
10thymic T cell selection (GO:0045061)5.55059557
11positive regulation of tolerance induction (GO:0002645)5.54276128
12positive T cell selection (GO:0043368)5.34874524
13regulation of gamma-delta T cell differentiation (GO:0045586)5.33770194
14positive regulation of humoral immune response (GO:0002922)5.33095763
15positive regulation of natural killer cell mediated immunity (GO:0002717)5.30025409
16regulation of B cell receptor signaling pathway (GO:0050855)5.29793840
17positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)5.21452651
18pyrimidine ribonucleoside catabolic process (GO:0046133)5.21238574
19signal complex assembly (GO:0007172)5.14731331
20positive regulation of leukocyte mediated cytotoxicity (GO:0001912)5.12436456
21positive thymic T cell selection (GO:0045059)5.06231760
22regulation of natural killer cell mediated cytotoxicity (GO:0042269)5.05623013
23regulation of natural killer cell mediated immunity (GO:0002715)5.05623013
24T cell selection (GO:0045058)4.98708432
25negative regulation of cell killing (GO:0031342)4.85496495
26negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.85496495
27negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)4.84826230
28regulation of regulatory T cell differentiation (GO:0045589)4.82483845
29cellular response to interleukin-15 (GO:0071350)4.81510320
30T cell receptor signaling pathway (GO:0050852)4.80498955
31regulation of antigen receptor-mediated signaling pathway (GO:0050854)4.74122631
32tolerance induction (GO:0002507)4.73351641
33positive regulation of T cell mediated cytotoxicity (GO:0001916)4.73087774
34positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.72121791
35regulation of tolerance induction (GO:0002643)4.68958613
36regulation of alpha-beta T cell proliferation (GO:0046640)4.66827212
37positive regulation of alpha-beta T cell proliferation (GO:0046641)4.66274336
38regulation of leukocyte mediated cytotoxicity (GO:0001910)4.61198027
39regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.53778175
40antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.44542583
41regulation of T cell receptor signaling pathway (GO:0050856)4.42962719
42positive regulation of cell killing (GO:0031343)4.42775764
43positive regulation of natural killer cell differentiation (GO:0032825)4.37341993
44activated T cell proliferation (GO:0050798)4.26981962
45response to interleukin-15 (GO:0070672)4.26789516
46negative regulation of lymphocyte mediated immunity (GO:0002707)4.25223511
47regulation of T cell mediated cytotoxicity (GO:0001914)4.24788840
48negative regulation of T cell receptor signaling pathway (GO:0050860)4.20532450
49antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.18851504
50regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.17994156
51negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)4.05249628
52regulation of cell killing (GO:0031341)3.97712294
53antigen receptor-mediated signaling pathway (GO:0050851)3.96393620
54DNA deamination (GO:0045006)3.94708105
55regulation of isotype switching to IgG isotypes (GO:0048302)3.89522522
56antigen processing and presentation of endogenous antigen (GO:0019883)3.85994194
57positive regulation of B cell mediated immunity (GO:0002714)3.83265104
58positive regulation of immunoglobulin mediated immune response (GO:0002891)3.83265104
59leukocyte aggregation (GO:0070486)3.76116103
60positive regulation of interleukin-4 production (GO:0032753)3.72812575
61regulation of interleukin-2 biosynthetic process (GO:0045076)3.72284560
62regulation of dendritic cell antigen processing and presentation (GO:0002604)3.71772588
63lymphocyte chemotaxis (GO:0048247)3.71121715
64alpha-beta T cell differentiation (GO:0046632)3.69507337
65negative regulation of interleukin-2 production (GO:0032703)3.61882952
66lymphocyte migration (GO:0072676)3.59154591
67positive regulation of granulocyte differentiation (GO:0030854)3.58312684
68cellular response to interleukin-4 (GO:0071353)3.56773267
69alpha-beta T cell activation (GO:0046631)3.53854778
70positive regulation of lymphocyte mediated immunity (GO:0002708)3.49412288
71mast cell activation (GO:0045576)3.48174575
72positive regulation of type 2 immune response (GO:0002830)3.46585788
73T cell migration (GO:0072678)3.45003283
74positive regulation of T cell cytokine production (GO:0002726)3.43348349
75negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.41432058
76cellular defense response (GO:0006968)3.40018825
77antigen processing and presentation via MHC class Ib (GO:0002475)3.39192993
78T cell differentiation (GO:0030217)3.37019926
79regulation of T cell cytokine production (GO:0002724)3.34672665
80regulation of interleukin-4 production (GO:0032673)3.34396594
81negative regulation of leukocyte mediated immunity (GO:0002704)3.32659310
82positive regulation of T cell chemotaxis (GO:0010820)3.32074100
83regulation of T cell chemotaxis (GO:0010819)3.32074100
84positive regulation of T cell mediated immunity (GO:0002711)3.29624086
85nucleotide-binding oligomerization domain containing signaling pathway (GO:0070423)3.27556966
86negative regulation of interferon-gamma production (GO:0032689)3.22662463
87cytidine metabolic process (GO:0046087)3.21725597
88cytidine catabolic process (GO:0006216)3.21725597
89cytidine deamination (GO:0009972)3.21725597
90regulation of T cell mediated immunity (GO:0002709)3.18611741
91negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.16595008
92regulation of natural killer cell differentiation (GO:0032823)3.13898675
93positive regulation of calcium-mediated signaling (GO:0050850)3.09881031
94type I interferon signaling pathway (GO:0060337)3.07731444
95cellular response to type I interferon (GO:0071357)3.07731444
96T cell costimulation (GO:0031295)3.06994892
97response to type I interferon (GO:0034340)3.05431161
98positive regulation of leukocyte mediated immunity (GO:0002705)3.03989139
99lymphocyte costimulation (GO:0031294)3.03503655
100positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.03424550

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse8.35587351
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human7.30210794
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.89599351
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.86932096
5RUNX_20019798_ChIP-Seq_JUKART_Human4.32245007
6BP1_19119308_ChIP-ChIP_Hs578T_Human4.31818139
7ELF1_17652178_ChIP-ChIP_JURKAT_Human4.05977026
8MYB_26560356_Chip-Seq_TH2_Human3.55401353
9IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.40334784
10IRF8_21731497_ChIP-ChIP_J774_Mouse3.29685119
11STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.22704300
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.11596281
13VDR_22108803_ChIP-Seq_LS180_Human3.04571064
14STAT4_19710469_ChIP-ChIP_TH1__Mouse2.97039224
15NOTCH1_21737748_ChIP-Seq_TLL_Human2.81423430
16FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.61668056
17FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.61253198
18MYB_26560356_Chip-Seq_TH1_Human2.54684709
19SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.43677242
20UTX_26944678_Chip-Seq_JUKART_Human2.40210997
21GATA3_27048872_Chip-Seq_THYMUS_Human2.36233723
22MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.29148115
23MAF_26560356_Chip-Seq_TH1_Human2.28201864
24STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.15829053
25RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.14331741
26MAF_26560356_Chip-Seq_TH2_Human2.13515114
27STAT6_21828071_ChIP-Seq_BEAS2B_Human1.98106471
28FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.91848575
29GATA3_26560356_Chip-Seq_TH2_Human1.91400496
30SPI1_23547873_ChIP-Seq_NB4_Human1.67757842
31SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.66798737
32IRF8_27001747_Chip-Seq_BMDM_Mouse1.49596797
33SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.46199000
34E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.45660822
35ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.43567779
36VDR_23849224_ChIP-Seq_CD4+_Human1.37956368
37SPI1_23127762_ChIP-Seq_K562_Human1.35651716
38RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.35373260
39VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.34805854
40FOXP3_21729870_ChIP-Seq_TREG_Human1.34191001
41MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.31088265
42MYB_21317192_ChIP-Seq_ERMYB_Mouse1.29285002
43CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.22186427
44MYC_22102868_ChIP-Seq_BL_Human1.18607075
45RUNX1_22412390_ChIP-Seq_EML_Mouse1.16189747
46NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.10566419
47KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.06442581
48EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.02902146
49LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.02457700
50LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.02295688
51CIITA_25753668_ChIP-Seq_RAJI_Human1.02243100
52CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.01809831
53VDR_24763502_ChIP-Seq_THP-1_Human1.00882118
54BRD4_27068464_Chip-Seq_AML-cells_Mouse1.00827988
55RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.00125963
56E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.98595416
57FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97036310
58JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.96545846
59TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94445874
60TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.93403883
61CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91010876
62VDR_21846776_ChIP-Seq_THP-1_Human0.90343148
63NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.89381255
64CTCF_26484167_Chip-Seq_Bcells_Mouse0.88684508
65SCL_19346495_ChIP-Seq_HPC-7_Human0.87880520
66GATA2_22383799_ChIP-Seq_G1ME_Mouse0.85173805
67CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.84775846
68TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.84616807
69GATA3_26560356_Chip-Seq_TH1_Human0.83317372
70BCL6_27268052_Chip-Seq_Bcells_Human0.82284808
71EGR1_19032775_ChIP-ChIP_M12_Human0.81834245
72CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.81025047
73ER_23166858_ChIP-Seq_MCF-7_Human0.80274731
74YY1_22570637_ChIP-Seq_MALME-3M_Human0.80256580
75PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.79939428
76PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.79632086
77RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.79143100
78P300_27268052_Chip-Seq_Bcells_Human0.79102619
79PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.78775856
80EZH2_22144423_ChIP-Seq_EOC_Human0.78684617
81RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.78145558
82NANOG_20526341_ChIP-Seq_ESCs_Human0.77220202
83KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.77088506
84SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.76954097
85GABP_17652178_ChIP-ChIP_JURKAT_Human0.75701733
86ELF1_20517297_ChIP-Seq_JURKAT_Human0.74368040
87SMAD_19615063_ChIP-ChIP_OVARY_Human0.73637186
88GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.71397014
89EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.70923737
90GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.69453806
91KDM2B_26808549_Chip-Seq_DND41_Human0.68596539
92RARB_24833708_ChIP-Seq_LIVER_Mouse0.68330995
93TDRD3_21172665_ChIP-Seq_MCF-7_Human0.67285962
94EST1_17652178_ChIP-ChIP_JURKAT_Human0.65421078
95SMRT_27268052_Chip-Seq_Bcells_Human0.65009765
96OCT4_20526341_ChIP-Seq_ESCs_Human0.64893046
97SPI1_20517297_ChIP-Seq_HL60_Human0.64271532
98FLI1_27457419_Chip-Seq_LIVER_Mouse0.63797169
99PU.1_20513432_ChIP-Seq_Bcells_Mouse0.61469096
100BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.60908717

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.86480681
2MP0003763_abnormal_thymus_physiology4.45125260
3MP0005451_abnormal_body_composition4.19218103
4MP0002822_catalepsy3.96366830
5MP0000685_abnormal_immune_system3.57302858
6MP0005000_abnormal_immune_tolerance3.35332096
7MP0001800_abnormal_humoral_immune3.05611162
8MP0001835_abnormal_antigen_presentation2.95032101
9MP0004947_skin_inflammation2.90906276
10MP0003300_gastrointestinal_ulcer2.89111353
11MP0003436_decreased_susceptibility_to2.85990892
12MP0002420_abnormal_adaptive_immunity2.82031309
13MP0001790_abnormal_immune_system2.80550660
14MP0005387_immune_system_phenotype2.80550660
15MP0001819_abnormal_immune_cell2.79813820
16MP0003866_abnormal_defecation2.69127699
17MP0002723_abnormal_immune_serum2.66701266
18MP0009785_altered_susceptibility_to2.65430888
19MP0004381_abnormal_hair_follicle2.65012847
20MP0005025_abnormal_response_to2.53286269
21MP0000703_abnormal_thymus_morphology2.52034617
22MP0009333_abnormal_splenocyte_physiolog2.50375820
23MP0002452_abnormal_antigen_presenting2.38698960
24MP0010155_abnormal_intestine_physiology2.37312359
25MP0002398_abnormal_bone_marrow2.31637413
26MP0002419_abnormal_innate_immunity2.19258737
27MP0005075_abnormal_melanosome_morpholog2.10787514
28MP0000716_abnormal_immune_system2.07780197
29MP0002405_respiratory_system_inflammati1.94179468
30MP0005310_abnormal_salivary_gland1.93605225
31MP0002722_abnormal_immune_system1.91842134
32MP0000689_abnormal_spleen_morphology1.88529857
33MP0001845_abnormal_inflammatory_respons1.87985398
34MP0001873_stomach_inflammation1.84703365
35MP0002148_abnormal_hypersensitivity_rea1.84167934
36MP0008961_abnormal_basal_metabolism1.73197971
37MP0003724_increased_susceptibility_to1.60754784
38MP0002429_abnormal_blood_cell1.53482101
39MP0000372_irregular_coat_pigmentation1.48637444
40MP0002006_tumorigenesis1.42457015
41MP0009764_decreased_sensitivity_to1.40299406
42MP0008260_abnormal_autophagy1.36022069
43MP0002132_abnormal_respiratory_system1.34351415
44MP0009765_abnormal_xenobiotic_induced1.29167091
45MP0002163_abnormal_gland_morphology1.28671051
46MP0001533_abnormal_skeleton_physiology1.27185763
47MP0001348_abnormal_lacrimal_gland1.26870804
48MP0000465_gastrointestinal_hemorrhage1.23810006
49MP0008469_abnormal_protein_level1.20591534
50MP0008995_early_reproductive_senescence1.19667280
51MP0002933_joint_inflammation1.18374813
52MP0005503_abnormal_tendon_morphology1.12773333
53MP0002735_abnormal_chemical_nociception1.07515649
54MP0002736_abnormal_nociception_after1.05187322
55MP0008872_abnormal_physiological_respon1.04793046
56MP0009763_increased_sensitivity_to0.99982175
57MP0002166_altered_tumor_susceptibility0.97221679
58MP0003646_muscle_fatigue0.97180597
59MP0002396_abnormal_hematopoietic_system0.95537546
60MP0001851_eye_inflammation0.95003749
61MP0002089_abnormal_postnatal_growth/wei0.94609696
62MP0003045_fibrosis0.94002489
63MP0002277_abnormal_respiratory_mucosa0.92135441
64MP0000613_abnormal_salivary_gland0.90414014
65MP0003448_altered_tumor_morphology0.87040842
66MP0006082_CNS_inflammation0.85646787
67MP0002102_abnormal_ear_morphology0.84525494
68MP0004859_abnormal_synaptic_plasticity0.80025414
69MP0000490_abnormal_crypts_of0.79462074
70MP0003137_abnormal_impulse_conducting0.78822963
71MP0003786_premature_aging0.78699109
72MP0001919_abnormal_reproductive_system0.75846643
73MP0006072_abnormal_retinal_apoptosis0.75721714
74MP0001663_abnormal_digestive_system0.70235559
75MP0003303_peritoneal_inflammation0.69497517
76MP0000383_abnormal_hair_follicle0.65575454
77MP0009697_abnormal_copulation0.64336011
78MP0001968_abnormal_touch/_nociception0.64249310
79MP0001346_abnormal_lacrimal_gland0.63898944
80MP0003880_abnormal_central_pattern0.63801521
81MP0004130_abnormal_muscle_cell0.62611555
82MP0002254_reproductive_system_inflammat0.61872441
83MP0003638_abnormal_response/metabolism_0.61264536
84MP0005464_abnormal_platelet_physiology0.60885010
85MP0002019_abnormal_tumor_incidence0.60327562
86MP0002693_abnormal_pancreas_physiology0.59737362
87MP0008877_abnormal_DNA_methylation0.55547536
88MP0000858_altered_metastatic_potential0.54209888
89MP0002009_preneoplasia0.52637178
90MP0002998_abnormal_bone_remodeling0.51270035
91MP0000477_abnormal_intestine_morphology0.48367253
92MP0002136_abnormal_kidney_physiology0.48306185
93MP0005379_endocrine/exocrine_gland_phen0.47309723
94MP0001664_abnormal_digestion0.46154347
95MP0005253_abnormal_eye_physiology0.45539477
96MP0005390_skeleton_phenotype0.45412166
97MP0002098_abnormal_vibrissa_morphology0.44305927
98MP0001501_abnormal_sleep_pattern0.40866980
99MP0005535_abnormal_body_temperature0.40666747
100MP0009115_abnormal_fat_cell0.39609826

Predicted human phenotypes

RankGene SetZ-score
1Increased IgM level (HP:0003496)8.10895323
2IgG deficiency (HP:0004315)7.16580896
3Optic neuritis (HP:0100653)6.24338648
4Retrobulbar optic neuritis (HP:0100654)6.24338648
5Encephalitis (HP:0002383)5.66649601
6Myositis (HP:0100614)5.60627484
7Orchitis (HP:0100796)5.58415930
8Keratoconjunctivitis sicca (HP:0001097)4.37627052
9Keratoconjunctivitis (HP:0001096)4.32185125
10Severe combined immunodeficiency (HP:0004430)4.16775939
11Acute hepatic failure (HP:0006554)4.05744090
12T lymphocytopenia (HP:0005403)4.00646509
13Abnormality of eosinophils (HP:0001879)3.77498075
14Hyperlipoproteinemia (HP:0010980)3.74284810
15Stenosis of the external auditory canal (HP:0000402)3.72862538
16Elevated erythrocyte sedimentation rate (HP:0003565)3.70932119
17Pustule (HP:0200039)3.65359180
18Autoimmune hemolytic anemia (HP:0001890)3.60025922
19Gastrointestinal infarctions (HP:0005244)3.58694238
20Eosinophilia (HP:0001880)3.49452940
21Abnormality of T cell number (HP:0011839)3.49397868
22Granulocytopenia (HP:0001913)3.43859355
23Hypergammaglobulinemia (HP:0010702)3.41531149
24Abnormality of T cells (HP:0002843)3.35898705
25Gangrene (HP:0100758)3.34346690
26Loss of speech (HP:0002371)3.34290709
27Meningitis (HP:0001287)3.29088640
28Thick nail (HP:0001805)3.28231101
29Eczematoid dermatitis (HP:0000976)3.27207592
30Combined immunodeficiency (HP:0005387)3.25711984
31Keratitis (HP:0000491)3.22551210
32Leukocytosis (HP:0001974)3.17683233
33Stomatitis (HP:0010280)3.14381296
34Hemoptysis (HP:0002105)3.10403625
35Congenital stationary night blindness (HP:0007642)3.07224847
36Pulmonary infiltrates (HP:0002113)3.06621146
37IgM deficiency (HP:0002850)3.03059454
38Abnormality of macrophages (HP:0004311)2.96075914
39Recurrent bronchitis (HP:0002837)2.92179827
40Chronic mucocutaneous candidiasis (HP:0002728)2.87615437
41Recurrent cutaneous fungal infections (HP:0011370)2.87615437
42Hypoplastic nipples (HP:0002557)2.87071385
43Anorexia (HP:0002039)2.75362018
44Chronic diarrhea (HP:0002028)2.74946660
45Sparse lateral eyebrow (HP:0005338)2.74666783
46B lymphocytopenia (HP:0010976)2.73736053
47Abnormality of T cell physiology (HP:0011840)2.72625764
48Diastasis recti (HP:0001540)2.70764394
49Vasculitis (HP:0002633)2.68758741
50Anteriorly placed anus (HP:0001545)2.67236655
51Choroideremia (HP:0001139)2.66479637
52Oligodontia (HP:0000677)2.59341622
53IgA deficiency (HP:0002720)2.59173999
54Thyroiditis (HP:0100646)2.52093950
55Joint swelling (HP:0001386)2.51981068
56Verrucae (HP:0200043)2.51680834
57Papilloma (HP:0012740)2.51680834
58Hypoproteinemia (HP:0003075)2.50577745
59Abnormality of pyrimidine metabolism (HP:0004353)2.47368334
60Mediastinal lymphadenopathy (HP:0100721)2.46218716
61Pulmonary embolism (HP:0002204)2.45124570
62Agammaglobulinemia (HP:0004432)2.44333882
63Arterial thrombosis (HP:0004420)2.42828199
64Abnormality of B cell number (HP:0010975)2.42353655
65Gingivitis (HP:0000230)2.41065418
66Recurrent fungal infections (HP:0002841)2.41014331
67Cellular immunodeficiency (HP:0005374)2.39522057
68Lymphopenia (HP:0001888)2.36498127
69Obstructive lung disease (HP:0006536)2.34854927
70Chronic obstructive pulmonary disease (HP:0006510)2.34854927
71Recurrent abscess formation (HP:0002722)2.30246657
72Abnormality of the fingertips (HP:0001211)2.27514202
73Conical tooth (HP:0000698)2.26283447
74Vertigo (HP:0002321)2.25392949
75Breast hypoplasia (HP:0003187)2.23734567
76Aplastic anemia (HP:0001915)2.23494866
77Erythema (HP:0010783)2.18203014
78Xanthomatosis (HP:0000991)2.17609090
79Hemorrhage of the eye (HP:0011885)2.16591503
80Abnormality of incisor morphology (HP:0011063)2.13843431
81Absent hand (HP:0004050)2.12988607
82Pancytopenia (HP:0001876)2.09255602
83Lymphoma (HP:0002665)2.08258223
84Short clavicles (HP:0000894)2.06999876
85Abnormality of cells of the lymphoid lineage (HP:0012140)2.05583812
86Supernumerary nipples (HP:0002558)2.04971215
87Anomalous pulmonary venous return (HP:0010772)1.99125162
88Increased IgE level (HP:0003212)1.98673105
89Hypoparathyroidism (HP:0000829)1.98511676
90Glomerulopathy (HP:0100820)1.92829352
91Abnormality of the pleura (HP:0002103)1.91451736
92Aplasia/Hypoplasia of the clavicles (HP:0006710)1.87613779
93Abnormal delayed hypersensitivity skin test (HP:0002963)1.86865205
94Acne (HP:0001061)1.86193004
95Ridged nail (HP:0001807)1.85134229
96Oral leukoplakia (HP:0002745)1.81878563
97Chest pain (HP:0100749)1.79330782
98Hepatitis (HP:0012115)1.78653884
99Spontaneous hematomas (HP:0007420)1.74904929
100Skin rash (HP:0000988)1.74416214

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK6.17699332
2GRK64.33179204
3MAP4K13.86564039
4EPHB13.40104494
5MAP3K133.22349488
6PASK3.14430987
7KDR2.61259174
8TLK12.53812651
9NEK62.43789606
10CAMKK22.26475598
11NLK2.25714074
12ITK2.24056061
13MAPKAPK32.23417764
14CLK12.20988903
15EPHA32.20770602
16CAMKK12.12157562
17SIK32.10085134
18FGFR41.85043746
19SIK21.83817490
20TEC1.79389828
21BTK1.72019512
22TESK21.66639618
23ACVR1B1.65818533
24SYK1.61769783
25CSK1.61282550
26LCK1.47464146
27HCK1.35131060
28IKBKB1.27949810
29FES1.27230488
30MARK31.25980196
31TAOK11.25605046
32BCKDK1.20227005
33MAP3K111.18664177
34MAP4K21.15130110
35NEK91.14705588
36RIPK41.11240589
37JAK31.10779666
38CDK61.09549612
39IKBKE1.07542414
40LYN1.07272062
41MAP3K71.06395815
42TYK21.01746966
43MAP3K140.98776390
44NME10.96350056
45DAPK10.95291230
46MELK0.89469595
47SIK10.88892316
48ERN10.87342442
49IRAK10.87125234
50JAK10.86879271
51FGFR30.86391096
52CDK40.86120047
53PRKCQ0.84082804
54ZAP700.79034466
55ALK0.72871977
56PTK2B0.71925545
57IRAK40.70437148
58FYN0.66148755
59MAP3K10.63621189
60JAK20.63456377
61TAOK30.56266526
62TNK20.52666395
63TYRO30.51951562
64IGF1R0.50710015
65MAP3K30.50438378
66TRPM70.46518752
67KIT0.42926606
68PIM10.39115613
69KSR20.39024427
70NUAK10.36385774
71TAOK20.35384517
72CDK80.34298690
73EGFR0.34054663
74FGFR20.33871244
75ERBB30.31418776
76MAPKAPK20.30494615
77MAP2K30.30379495
78TBK10.28252707
79RAF10.28154669
80YES10.27581128
81TESK10.26096120
82MAPK110.24713137
83IRAK30.23209449
84PIK3CG0.23205657
85CDK140.22404037
86BLK0.20973089
87ABL10.20905148
88HIPK20.20576016
89PRKCD0.20177297
90CSF1R0.19953618
91NTRK20.19681964
92GRK70.19421085
93CDK11A0.19316644
94PAK60.18860321
95MAPK120.18084364
96FER0.16543304
97PRKAA20.16305438
98MAPK70.15815330
99CDK150.14350534
100INSR0.11518200

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053406.45287956
2T cell receptor signaling pathway_Homo sapiens_hsa046603.72856792
3Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.74647601
4Measles_Homo sapiens_hsa051622.69695764
5Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.65758053
6Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.64603121
7Hematopoietic cell lineage_Homo sapiens_hsa046402.43707941
8Antigen processing and presentation_Homo sapiens_hsa046122.30045497
9Autoimmune thyroid disease_Homo sapiens_hsa053202.24627992
10Allograft rejection_Homo sapiens_hsa053302.17189718
11Intestinal immune network for IgA production_Homo sapiens_hsa046722.15916333
12Shigellosis_Homo sapiens_hsa051312.12632577
13Chemokine signaling pathway_Homo sapiens_hsa040622.10434333
14Graft-versus-host disease_Homo sapiens_hsa053322.07466278
15alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.89362431
16Linoleic acid metabolism_Homo sapiens_hsa005911.85740983
17NF-kappa B signaling pathway_Homo sapiens_hsa040641.82332364
18Ribosome_Homo sapiens_hsa030101.71930699
19NOD-like receptor signaling pathway_Homo sapiens_hsa046211.59269745
20Jak-STAT signaling pathway_Homo sapiens_hsa046301.58685552
21Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.56537218
22RNA polymerase_Homo sapiens_hsa030201.56050704
23Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.51739445
24Acute myeloid leukemia_Homo sapiens_hsa052211.48605286
25RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.46911860
26Type I diabetes mellitus_Homo sapiens_hsa049401.46131501
27Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.43515213
28SNARE interactions in vesicular transport_Homo sapiens_hsa041301.43076613
29B cell receptor signaling pathway_Homo sapiens_hsa046621.41327946
30Osteoclast differentiation_Homo sapiens_hsa043801.40637822
31Malaria_Homo sapiens_hsa051441.35672205
32Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.35524876
33Leukocyte transendothelial migration_Homo sapiens_hsa046701.27263228
34Viral myocarditis_Homo sapiens_hsa054161.22433806
35Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.12113335
36Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.09527881
37Staphylococcus aureus infection_Homo sapiens_hsa051500.90213680
38Toxoplasmosis_Homo sapiens_hsa051450.84631287
39TNF signaling pathway_Homo sapiens_hsa046680.83711160
40Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.83161900
41Herpes simplex infection_Homo sapiens_hsa051680.82287390
42Platelet activation_Homo sapiens_hsa046110.81503242
43Rheumatoid arthritis_Homo sapiens_hsa053230.80731451
44Ovarian steroidogenesis_Homo sapiens_hsa049130.79172705
45Toll-like receptor signaling pathway_Homo sapiens_hsa046200.78508932
46Epstein-Barr virus infection_Homo sapiens_hsa051690.78329250
47VEGF signaling pathway_Homo sapiens_hsa043700.77933440
48Tuberculosis_Homo sapiens_hsa051520.77036042
49Leishmaniasis_Homo sapiens_hsa051400.75855208
50Ether lipid metabolism_Homo sapiens_hsa005650.72718325
51Homologous recombination_Homo sapiens_hsa034400.71856699
52Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.67934313
53HTLV-I infection_Homo sapiens_hsa051660.65210058
54Pancreatic cancer_Homo sapiens_hsa052120.64851831
55Serotonergic synapse_Homo sapiens_hsa047260.63586609
56Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.62549103
57Ras signaling pathway_Homo sapiens_hsa040140.59637409
58Arachidonic acid metabolism_Homo sapiens_hsa005900.58934675
59Asthma_Homo sapiens_hsa053100.58121593
60Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.58072570
61Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.56088254
62Chemical carcinogenesis_Homo sapiens_hsa052040.55810267
63Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.53897034
64Pertussis_Homo sapiens_hsa051330.50559221
65Hepatitis C_Homo sapiens_hsa051600.49024331
66Viral carcinogenesis_Homo sapiens_hsa052030.48336577
67Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.48057848
68Pyrimidine metabolism_Homo sapiens_hsa002400.44860154
69Adipocytokine signaling pathway_Homo sapiens_hsa049200.44431634
70Endocytosis_Homo sapiens_hsa041440.43585134
71Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.42602294
72Hepatitis B_Homo sapiens_hsa051610.41048344
73Systemic lupus erythematosus_Homo sapiens_hsa053220.40372140
74Glycerophospholipid metabolism_Homo sapiens_hsa005640.38712638
75Proteasome_Homo sapiens_hsa030500.37781065
76Choline metabolism in cancer_Homo sapiens_hsa052310.36236119
77Legionellosis_Homo sapiens_hsa051340.36178440
78MAPK signaling pathway_Homo sapiens_hsa040100.35928296
79Phototransduction_Homo sapiens_hsa047440.35919137
80Apoptosis_Homo sapiens_hsa042100.35316187
81Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.35220561
82Salmonella infection_Homo sapiens_hsa051320.34362621
83Gastric acid secretion_Homo sapiens_hsa049710.34183654
84Drug metabolism - other enzymes_Homo sapiens_hsa009830.29007432
85Glycerolipid metabolism_Homo sapiens_hsa005610.28789516
86Influenza A_Homo sapiens_hsa051640.28651098
87Morphine addiction_Homo sapiens_hsa050320.27367117
88Fanconi anemia pathway_Homo sapiens_hsa034600.27214547
89Vascular smooth muscle contraction_Homo sapiens_hsa042700.26607191
90Olfactory transduction_Homo sapiens_hsa047400.26526100
91Regulation of autophagy_Homo sapiens_hsa041400.25462901
92Nitrogen metabolism_Homo sapiens_hsa009100.25225888
93Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.25180003
94Oxytocin signaling pathway_Homo sapiens_hsa049210.23184467
95Glutamatergic synapse_Homo sapiens_hsa047240.22846787
96Phagosome_Homo sapiens_hsa041450.22637096
97Phospholipase D signaling pathway_Homo sapiens_hsa040720.22490422
98Rap1 signaling pathway_Homo sapiens_hsa040150.21671953
99Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.20854053
100Insulin resistance_Homo sapiens_hsa049310.19951683

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