

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | negative T cell selection (GO:0043383) | 8.85169969 |
| 2 | positive regulation of gamma-delta T cell activation (GO:0046645) | 8.39709308 |
| 3 | negative thymic T cell selection (GO:0045060) | 8.32937520 |
| 4 | antigen processing and presentation of endogenous peptide antigen (GO:0002483) | 8.15719352 |
| 5 | antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885) | 8.15719352 |
| 6 | positive T cell selection (GO:0043368) | 8.04714450 |
| 7 | positive thymic T cell selection (GO:0045059) | 7.66503629 |
| 8 | positive regulation of antigen receptor-mediated signaling pathway (GO:0050857) | 7.48643817 |
| 9 | regulation of gamma-delta T cell differentiation (GO:0045586) | 7.16578542 |
| 10 | thymic T cell selection (GO:0045061) | 7.11842827 |
| 11 | T cell selection (GO:0045058) | 7.05249501 |
| 12 | antigen processing and presentation of endogenous antigen (GO:0019883) | 6.77380992 |
| 13 | negative regulation of cell killing (GO:0031342) | 6.64323186 |
| 14 | negative regulation of leukocyte mediated cytotoxicity (GO:0001911) | 6.64323186 |
| 15 | regulation of gamma-delta T cell activation (GO:0046643) | 6.44002531 |
| 16 | positive regulation of interleukin-2 biosynthetic process (GO:0045086) | 6.37609166 |
| 17 | regulation of isotype switching to IgG isotypes (GO:0048302) | 6.26201437 |
| 18 | T cell receptor signaling pathway (GO:0050852) | 5.99122061 |
| 19 | leukocyte aggregation (GO:0070486) | 5.74028242 |
| 20 | interferon-gamma production (GO:0032609) | 5.67271002 |
| 21 | T cell migration (GO:0072678) | 5.50787388 |
| 22 | response to interleukin-15 (GO:0070672) | 5.48480874 |
| 23 | T cell costimulation (GO:0031295) | 5.47714748 |
| 24 | lymphocyte costimulation (GO:0031294) | 5.40601433 |
| 25 | tolerance induction (GO:0002507) | 5.37957915 |
| 26 | production of molecular mediator involved in inflammatory response (GO:0002532) | 5.34766519 |
| 27 | cellular response to interleukin-15 (GO:0071350) | 5.18030929 |
| 28 | regulation of T cell tolerance induction (GO:0002664) | 5.12694678 |
| 29 | regulation of regulatory T cell differentiation (GO:0045589) | 5.04358971 |
| 30 | regulation of T cell receptor signaling pathway (GO:0050856) | 4.92056761 |
| 31 | antigen receptor-mediated signaling pathway (GO:0050851) | 4.87414450 |
| 32 | regulation of antigen receptor-mediated signaling pathway (GO:0050854) | 4.69036883 |
| 33 | regulation of alpha-beta T cell proliferation (GO:0046640) | 4.66816606 |
| 34 | regulation of interleukin-12 biosynthetic process (GO:0045075) | 4.65659740 |
| 35 | regulation of interleukin-2 biosynthetic process (GO:0045076) | 4.56432736 |
| 36 | regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923) | 4.43936383 |
| 37 | negative regulation of lymphocyte mediated immunity (GO:0002707) | 4.42108358 |
| 38 | positive regulation of interleukin-2 production (GO:0032743) | 4.35857916 |
| 39 | positive regulation of alpha-beta T cell proliferation (GO:0046641) | 4.34571762 |
| 40 | mast cell activation (GO:0045576) | 4.32295651 |
| 41 | regulation of B cell receptor signaling pathway (GO:0050855) | 4.24240259 |
| 42 | V(D)J recombination (GO:0033151) | 4.22071795 |
| 43 | activated T cell proliferation (GO:0050798) | 4.15969836 |
| 44 | cell wall macromolecule metabolic process (GO:0044036) | 4.12784354 |
| 45 | positive regulation of tolerance induction (GO:0002645) | 4.12713974 |
| 46 | T cell differentiation (GO:0030217) | 4.10222208 |
| 47 | alpha-beta T cell differentiation (GO:0046632) | 3.94142803 |
| 48 | positive regulation of humoral immune response (GO:0002922) | 3.93251140 |
| 49 | positive regulation of interleukin-4 production (GO:0032753) | 3.87736694 |
| 50 | alpha-beta T cell activation (GO:0046631) | 3.86587993 |
| 51 | regulation of T cell mediated cytotoxicity (GO:0001914) | 3.75989218 |
| 52 | positive regulation of chemokine secretion (GO:0090197) | 3.73518077 |
| 53 | regulation of B cell differentiation (GO:0045577) | 3.69758611 |
| 54 | regulation of isotype switching (GO:0045191) | 3.69646403 |
| 55 | positive regulation of natural killer cell mediated cytotoxicity (GO:0045954) | 3.67158004 |
| 56 | positive regulation of natural killer cell mediated immunity (GO:0002717) | 3.67158004 |
| 57 | positive regulation of T cell mediated cytotoxicity (GO:0001916) | 3.66966539 |
| 58 | negative regulation of leukocyte mediated immunity (GO:0002704) | 3.65907484 |
| 59 | T cell differentiation involved in immune response (GO:0002292) | 3.64751939 |
| 60 | alpha-beta T cell differentiation involved in immune response (GO:0002293) | 3.64751939 |
| 61 | alpha-beta T cell activation involved in immune response (GO:0002287) | 3.64751939 |
| 62 | positive regulation of isotype switching (GO:0045830) | 3.61733758 |
| 63 | T cell activation (GO:0042110) | 3.60618974 |
| 64 | regulation of antigen processing and presentation of peptide antigen (GO:0002583) | 3.60080543 |
| 65 | regulation of defense response to virus by virus (GO:0050690) | 3.59083553 |
| 66 | regulation of natural killer cell mediated immunity (GO:0002715) | 3.58743986 |
| 67 | regulation of natural killer cell mediated cytotoxicity (GO:0042269) | 3.58743986 |
| 68 | regulation of tolerance induction (GO:0002643) | 3.57231777 |
| 69 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G | 3.56580908 |
| 70 | positive regulation of B cell differentiation (GO:0045579) | 3.55489848 |
| 71 | regulation of immunoglobulin production (GO:0002637) | 3.54320756 |
| 72 | antigen processing and presentation via MHC class Ib (GO:0002475) | 3.54051901 |
| 73 | negative regulation of T cell receptor signaling pathway (GO:0050860) | 3.53637275 |
| 74 | negative regulation of T cell mediated immunity (GO:0002710) | 3.51783087 |
| 75 | regulation of response to interferon-gamma (GO:0060330) | 3.51274503 |
| 76 | detection of bacterium (GO:0016045) | 3.49581263 |
| 77 | positive regulation of immunoglobulin production (GO:0002639) | 3.49122912 |
| 78 | CD4-positive, alpha-beta T cell differentiation (GO:0043367) | 3.48187228 |
| 79 | positive regulation by symbiont of host defense response (GO:0052509) | 3.48156475 |
| 80 | modulation by symbiont of host defense response (GO:0052031) | 3.48156475 |
| 81 | modulation by organism of immune response of other organism involved in symbiotic interaction (GO:00 | 3.48156475 |
| 82 | modulation by organism of defense response of other organism involved in symbiotic interaction (GO:0 | 3.48156475 |
| 83 | positive regulation by organism of defense response of other organism involved in symbiotic interact | 3.48156475 |
| 84 | modulation by symbiont of host immune response (GO:0052553) | 3.48156475 |
| 85 | detection of other organism (GO:0098543) | 3.42109342 |
| 86 | T cell homeostasis (GO:0043029) | 3.40882481 |
| 87 | tumor necrosis factor-mediated signaling pathway (GO:0033209) | 3.40389353 |
| 88 | regulation of immunoglobulin secretion (GO:0051023) | 3.39029843 |
| 89 | cellular response to type I interferon (GO:0071357) | 3.38563139 |
| 90 | type I interferon signaling pathway (GO:0060337) | 3.38563139 |
| 91 | negative regulation of antigen receptor-mediated signaling pathway (GO:0050858) | 3.37739934 |
| 92 | positive regulation of granulocyte differentiation (GO:0030854) | 3.36822408 |
| 93 | immune response-activating cell surface receptor signaling pathway (GO:0002429) | 3.36175796 |
| 94 | regulation of chemokine secretion (GO:0090196) | 3.35661188 |
| 95 | response to type I interferon (GO:0034340) | 3.35142092 |
| 96 | regulation of immunoglobulin mediated immune response (GO:0002889) | 3.35134642 |
| 97 | positive regulation of B cell mediated immunity (GO:0002714) | 3.34306325 |
| 98 | positive regulation of immunoglobulin mediated immune response (GO:0002891) | 3.34306325 |
| 99 | regulation of interferon-gamma-mediated signaling pathway (GO:0060334) | 3.32410393 |
| 100 | negative regulation of interleukin-12 production (GO:0032695) | 3.30715784 |
| 101 | cellular response to interleukin-4 (GO:0071353) | 3.28584695 |
| 102 | viral transcription (GO:0019083) | 3.26803767 |
| 103 | interferon-gamma secretion (GO:0072643) | 3.25967109 |
| 104 | dendritic cell chemotaxis (GO:0002407) | 3.24840625 |
| 105 | regulation of histone H3-K27 methylation (GO:0061085) | 3.22025395 |
| 106 | cellular defense response (GO:0006968) | 3.21959464 |
| 107 | regulation of B cell mediated immunity (GO:0002712) | 3.21921561 |
| 108 | CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294) | 3.21155462 |
| 109 | T-helper cell differentiation (GO:0042093) | 3.21155462 |
| 110 | T cell proliferation (GO:0042098) | 3.19729600 |
| 111 | positive regulation of T cell activation (GO:0050870) | 3.19116920 |
| 112 | regulation of interleukin-2 production (GO:0032663) | 3.18963959 |
| 113 | NIK/NF-kappaB signaling (GO:0038061) | 3.16985425 |
| 114 | positive regulation of type I interferon-mediated signaling pathway (GO:0060340) | 3.16835139 |
| 115 | cellular extravasation (GO:0045123) | 3.15719728 |
| 116 | leukocyte cell-cell adhesion (GO:0007159) | 3.13810178 |
| 117 | positive regulation of DNA recombination (GO:0045911) | 3.13686730 |
| 118 | regulation of leukocyte mediated cytotoxicity (GO:0001910) | 3.12186507 |
| 119 | positive regulation of leukocyte mediated cytotoxicity (GO:0001912) | 3.11467893 |
| 120 | negative regulation of adaptive immune response based on somatic recombination of immune receptors b | 3.11119478 |
| 121 | translational termination (GO:0006415) | 3.11004937 |
| 122 | negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515) | 3.10113330 |
| 123 | JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397) | 3.09943126 |
| 124 | CD4-positive, alpha-beta T cell activation (GO:0035710) | 3.08961141 |
| 125 | regulation of alpha-beta T cell activation (GO:0046634) | 3.06796468 |
| 126 | natural killer cell activation (GO:0030101) | 3.06544751 |
| 127 | regulation of cell killing (GO:0031341) | 3.06532978 |
| 128 | positive regulation of T cell differentiation in thymus (GO:0033089) | 3.04985416 |
| 129 | sequestering of actin monomers (GO:0042989) | 3.04660425 |
| 130 | respiratory burst (GO:0045730) | 3.04594288 |
| 131 | neutrophil activation involved in immune response (GO:0002283) | 3.04387583 |
| 132 | mucosal-associated lymphoid tissue development (GO:0048537) | 3.03854756 |
| 133 | Peyers patch development (GO:0048541) | 3.03854756 |
| 134 | negative regulation of adaptive immune response (GO:0002820) | 3.02413694 |
| 135 | dendritic cell migration (GO:0036336) | 3.02111398 |
| 136 | regulation of type I interferon-mediated signaling pathway (GO:0060338) | 3.00690997 |
| 137 | positive regulation of inflammatory response to antigenic stimulus (GO:0002863) | 2.98820184 |
| 138 | response to interleukin-4 (GO:0070670) | 2.95424088 |
| 139 | lymphocyte migration (GO:0072676) | 2.95208636 |
| 140 | regulation of T cell activation (GO:0050863) | 2.94803069 |
| 141 | regulation of interleukin-4 production (GO:0032673) | 2.92398756 |
| 142 | mast cell degranulation (GO:0043303) | 2.92098029 |
| 143 | mast cell activation involved in immune response (GO:0002279) | 2.92098029 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 9.23588153 |
| 2 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 6.08116526 |
| 3 | RUNX_20019798_ChIP-Seq_JUKART_Human | 4.04010634 |
| 4 | STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 4.03603430 |
| 5 | MYC_22102868_ChIP-Seq_BL_Human | 3.83901262 |
| 6 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 3.83462809 |
| 7 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 3.71186503 |
| 8 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 3.62062816 |
| 9 | FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse | 3.61845386 |
| 10 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 3.50318107 |
| 11 | MYB_26560356_Chip-Seq_TH2_Human | 3.44254559 |
| 12 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 3.34331644 |
| 13 | E2F7_22180533_ChIP-Seq_HELA_Human | 3.30830486 |
| 14 | MAF_26560356_Chip-Seq_TH1_Human | 3.14628878 |
| 15 | UTX_26944678_Chip-Seq_JUKART_Human | 2.99843148 |
| 16 | MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 2.75120720 |
| 17 | MYB_26560356_Chip-Seq_TH1_Human | 2.69940802 |
| 18 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 2.46339700 |
| 19 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 2.46319247 |
| 20 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 2.45819584 |
| 21 | KDM2B_26808549_Chip-Seq_HPB-ALL_Human | 2.27568545 |
| 22 | MAF_26560356_Chip-Seq_TH2_Human | 2.25372747 |
| 23 | GATA3_27048872_Chip-Seq_THYMUS_Human | 2.23948656 |
| 24 | VDR_21846776_ChIP-Seq_THP-1_Human | 2.23206731 |
| 25 | TCF7_22412390_ChIP-Seq_EML_Mouse | 2.09615055 |
| 26 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 2.00382394 |
| 27 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.96392315 |
| 28 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 1.88976354 |
| 29 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.86491100 |
| 30 | KDM2B_26808549_Chip-Seq_DND41_Human | 1.83860824 |
| 31 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 1.83155793 |
| 32 | RUNX1_22412390_ChIP-Seq_EML_Mouse | 1.76068229 |
| 33 | E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 1.75316325 |
| 34 | SCL_19346495_ChIP-Seq_HPC-7_Human | 1.68703027 |
| 35 | VDR_24763502_ChIP-Seq_THP-1_Human | 1.66542419 |
| 36 | SPI1_23547873_ChIP-Seq_NB4_Human | 1.65466837 |
| 37 | NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse | 1.61605004 |
| 38 | SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse | 1.58011524 |
| 39 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 1.57320724 |
| 40 | RUNX1_17652178_ChIP-ChIP_JURKAT_Human | 1.56757715 |
| 41 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.54871177 |
| 42 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.54433358 |
| 43 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 1.52815121 |
| 44 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 1.50218740 |
| 45 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.47277934 |
| 46 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.47226507 |
| 47 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 1.41896069 |
| 48 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.40486190 |
| 49 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.39099882 |
| 50 | MEIS1_20887958_ChIP-Seq_HPC-7_Mouse | 1.36371197 |
| 51 | IRF8_27001747_Chip-Seq_BMDM_Mouse | 1.36201422 |
| 52 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 1.33941880 |
| 53 | BRD4_27068464_Chip-Seq_AML-cells_Mouse | 1.31387434 |
| 54 | SPI1_23127762_ChIP-Seq_K562_Human | 1.28979727 |
| 55 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 1.26598950 |
| 56 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.26011772 |
| 57 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 1.25571510 |
| 58 | KDM2B_26808549_Chip-Seq_JURKAT_Human | 1.24256865 |
| 59 | VDR_24787735_ChIP-Seq_THP-1_Human | 1.24102166 |
| 60 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 1.22938761 |
| 61 | GATA3_26560356_Chip-Seq_TH2_Human | 1.22604689 |
| 62 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.17104326 |
| 63 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 1.14392969 |
| 64 | PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.13193544 |
| 65 | VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human | 1.13079150 |
| 66 | GATA2_22383799_ChIP-Seq_G1ME_Mouse | 1.12007158 |
| 67 | VDR_23849224_ChIP-Seq_CD4+_Human | 1.10424740 |
| 68 | BCL6_27268052_Chip-Seq_Bcells_Human | 1.10395101 |
| 69 | CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.10227296 |
| 70 | PU_27001747_Chip-Seq_BMDM_Mouse | 1.09009556 |
| 71 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 1.08656088 |
| 72 | GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.07952347 |
| 73 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.06294976 |
| 74 | PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.06035389 |
| 75 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 1.05524985 |
| 76 | SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 0.99764932 |
| 77 | TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse | 0.97804971 |
| 78 | SMRT_27268052_Chip-Seq_Bcells_Human | 0.97545368 |
| 79 | GATA1_22025678_ChIP-Seq_K562_Human | 0.97311237 |
| 80 | Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse | 0.95163099 |
| 81 | BCOR_27268052_Chip-Seq_Bcells_Human | 0.93449436 |
| 82 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 0.92611523 |
| 83 | GATA3_26560356_Chip-Seq_TH1_Human | 0.91894823 |
| 84 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 0.91852948 |
| 85 | ELK1_19687146_ChIP-ChIP_HELA_Human | 0.89389867 |
| 86 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 0.89133288 |
| 87 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 0.86483960 |
| 88 | GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.84629216 |
| 89 | PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 0.84406707 |
| 90 | CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse | 0.83621924 |
| 91 | CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 0.83374262 |
| 92 | PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse | 0.82881067 |
| 93 | GATA2_21666600_ChIP-Seq_HMVEC_Human | 0.82544534 |
| 94 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 0.81853151 |
| 95 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 0.81376653 |
| 96 | GATA1_22383799_ChIP-Seq_G1ME_Mouse | 0.80950850 |
| 97 | P300_27268052_Chip-Seq_Bcells_Human | 0.80430545 |
| 98 | BMI1_19503595_ChIP-Seq_MEFsC_Mouse | 0.78049992 |
| 99 | NCOR1_26117541_ChIP-Seq_K562_Human | 0.77487756 |
| 100 | RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.77375462 |
| 101 | CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse | 0.77080376 |
| 102 | XRN2_22483619_ChIP-Seq_HELA_Human | 0.76815135 |
| 103 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 0.76156186 |
| 104 | PU.1_20513432_ChIP-Seq_Bcells_Mouse | 0.75116563 |
| 105 | SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human | 0.73819169 |
| 106 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 0.73115046 |
| 107 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 0.72180051 |
| 108 | RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.71186695 |
| 109 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.71129375 |
| 110 | LMO2_20887958_ChIP-Seq_HPC-7_Mouse | 0.70552264 |
| 111 | GATA2_20887958_ChIP-Seq_HPC-7_Mouse | 0.66997824 |
| 112 | GATA1_19941826_ChIP-Seq_K562_Human | 0.65993293 |
| 113 | ETS1_22383799_ChIP-Seq_G1ME_Mouse | 0.64201430 |
| 114 | KDM5A_27292631_Chip-Seq_BREAST_Human | 0.63842418 |
| 115 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.61393358 |
| 116 | NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human | 0.61342201 |
| 117 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 0.60598332 |
| 118 | TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.58408724 |
| 119 | CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human | 0.57824523 |
| 120 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 0.56903069 |
| 121 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 0.56471405 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003763_abnormal_thymus_physiology | 6.47816857 |
| 2 | MP0005671_abnormal_response_to | 4.51531260 |
| 3 | MP0000685_abnormal_immune_system | 3.75079865 |
| 4 | MP0002166_altered_tumor_susceptibility | 3.45412243 |
| 5 | MP0009333_abnormal_splenocyte_physiolog | 3.30363202 |
| 6 | MP0001835_abnormal_antigen_presentation | 3.14267386 |
| 7 | MP0000703_abnormal_thymus_morphology | 3.10692284 |
| 8 | MP0001800_abnormal_humoral_immune | 2.97854912 |
| 9 | MP0002398_abnormal_bone_marrow | 2.95621070 |
| 10 | MP0002420_abnormal_adaptive_immunity | 2.87528658 |
| 11 | MP0005000_abnormal_immune_tolerance | 2.85783421 |
| 12 | MP0001819_abnormal_immune_cell | 2.84191192 |
| 13 | MP0001790_abnormal_immune_system | 2.77011675 |
| 14 | MP0005387_immune_system_phenotype | 2.77011675 |
| 15 | MP0002006_tumorigenesis | 2.75124913 |
| 16 | MP0002723_abnormal_immune_serum | 2.66408437 |
| 17 | MP0003300_gastrointestinal_ulcer | 2.64596527 |
| 18 | MP0003724_increased_susceptibility_to | 2.63038650 |
| 19 | MP0000716_abnormal_immune_system | 2.56786226 |
| 20 | MP0002722_abnormal_immune_system | 2.43906094 |
| 21 | MP0002452_abnormal_antigen_presenting | 2.42302216 |
| 22 | MP0003436_decreased_susceptibility_to | 2.40915385 |
| 23 | MP0009785_altered_susceptibility_to | 2.38392475 |
| 24 | MP0002405_respiratory_system_inflammati | 2.37004262 |
| 25 | MP0003866_abnormal_defecation | 2.28486717 |
| 26 | MP0005025_abnormal_response_to | 2.27227564 |
| 27 | MP0000689_abnormal_spleen_morphology | 2.27139808 |
| 28 | MP0001873_stomach_inflammation | 2.23079505 |
| 29 | MP0010155_abnormal_intestine_physiology | 2.22442665 |
| 30 | MP0002933_joint_inflammation | 2.21575329 |
| 31 | MP0004947_skin_inflammation | 2.20334671 |
| 32 | MP0002396_abnormal_hematopoietic_system | 2.09306978 |
| 33 | MP0002429_abnormal_blood_cell | 2.06134240 |
| 34 | MP0004381_abnormal_hair_follicle | 2.04914805 |
| 35 | MP0002148_abnormal_hypersensitivity_rea | 1.90624094 |
| 36 | MP0001853_heart_inflammation | 1.85753515 |
| 37 | MP0006082_CNS_inflammation | 1.84590232 |
| 38 | MP0003303_peritoneal_inflammation | 1.83252106 |
| 39 | MP0004510_myositis | 1.76326935 |
| 40 | MP0002277_abnormal_respiratory_mucosa | 1.70107556 |
| 41 | MP0004808_abnormal_hematopoietic_stem | 1.68005877 |
| 42 | MP0001845_abnormal_inflammatory_respons | 1.62570438 |
| 43 | MP0002419_abnormal_innate_immunity | 1.55135275 |
| 44 | MP0005310_abnormal_salivary_gland | 1.45737252 |
| 45 | MP0002163_abnormal_gland_morphology | 1.35853736 |
| 46 | MP0000858_altered_metastatic_potential | 1.34651438 |
| 47 | MP0005464_abnormal_platelet_physiology | 1.33399541 |
| 48 | MP0005075_abnormal_melanosome_morpholog | 1.23807392 |
| 49 | MP0002009_preneoplasia | 1.14624783 |
| 50 | MP0001545_abnormal_hematopoietic_system | 1.13679317 |
| 51 | MP0005397_hematopoietic_system_phenotyp | 1.13679317 |
| 52 | MP0003448_altered_tumor_morphology | 1.13327945 |
| 53 | MP0000490_abnormal_crypts_of | 1.12299278 |
| 54 | MP0000465_gastrointestinal_hemorrhage | 1.09915609 |
| 55 | MP0008260_abnormal_autophagy | 1.07941082 |
| 56 | MP0001533_abnormal_skeleton_physiology | 1.05797212 |
| 57 | MP0002822_catalepsy | 1.05202435 |
| 58 | MP0003172_abnormal_lysosome_physiology | 1.03260610 |
| 59 | MP0002019_abnormal_tumor_incidence | 0.96940174 |
| 60 | MP0008469_abnormal_protein_level | 0.96757624 |
| 61 | MP0008057_abnormal_DNA_replication | 0.95536424 |
| 62 | MP0002998_abnormal_bone_remodeling | 0.94640992 |
| 63 | MP0005023_abnormal_wound_healing | 0.92905649 |
| 64 | MP0003828_pulmonary_edema | 0.91241705 |
| 65 | MP0005076_abnormal_cell_differentiation | 0.87201400 |
| 66 | MP0001851_eye_inflammation | 0.87195379 |
| 67 | MP0004883_abnormal_blood_vessel | 0.84854967 |
| 68 | MP0003191_abnormal_cellular_cholesterol | 0.81026780 |
| 69 | MP0009765_abnormal_xenobiotic_induced | 0.80833559 |
| 70 | MP0001348_abnormal_lacrimal_gland | 0.76321413 |
| 71 | MP0009763_increased_sensitivity_to | 0.75796985 |
| 72 | MP0003077_abnormal_cell_cycle | 0.74444395 |
| 73 | MP0005381_digestive/alimentary_phenotyp | 0.71921022 |
| 74 | MP0008961_abnormal_basal_metabolism | 0.71749873 |
| 75 | MP0004130_abnormal_muscle_cell | 0.71457896 |
| 76 | MP0010352_gastrointestinal_tract_polyps | 0.70822743 |
| 77 | MP0008872_abnormal_physiological_respon | 0.68700127 |
| 78 | MP0003878_abnormal_ear_physiology | 0.68358037 |
| 79 | MP0005377_hearing/vestibular/ear_phenot | 0.68358037 |
| 80 | MP0005164_abnormal_response_to | 0.65789496 |
| 81 | MP0001243_abnormal_dermal_layer | 0.65493090 |
| 82 | MP0003795_abnormal_bone_structure | 0.65133573 |
| 83 | MP0003787_abnormal_imprinting | 0.64693181 |
| 84 | MP0000609_abnormal_liver_physiology | 0.62795344 |
| 85 | MP0000477_abnormal_intestine_morphology | 0.60122250 |
| 86 | MP0005166_decreased_susceptibility_to | 0.59765930 |
| 87 | MP0005390_skeleton_phenotype | 0.59203095 |
| 88 | MP0002138_abnormal_hepatobiliary_system | 0.58462039 |
| 89 | MP0004957_abnormal_blastocyst_morpholog | 0.57342750 |
| 90 | MP0002127_abnormal_cardiovascular_syste | 0.57244525 |
| 91 | MP0005379_endocrine/exocrine_gland_phen | 0.54642888 |
| 92 | MP0001764_abnormal_homeostasis | 0.54002028 |
| 93 | MP0003453_abnormal_keratinocyte_physiol | 0.53743438 |
| 94 | MP0010234_abnormal_vibrissa_follicle | 0.53448051 |
| 95 | MP0003045_fibrosis | 0.52931269 |
| 96 | MP0003646_muscle_fatigue | 0.52560789 |
| 97 | MP0003221_abnormal_cardiomyocyte_apopto | 0.52553786 |
| 98 | MP0008877_abnormal_DNA_methylation | 0.51762483 |
| 99 | MP0000604_amyloidosis | 0.49278073 |
| 100 | MP0008873_increased_physiological_sensi | 0.48919975 |
| 101 | MP0001216_abnormal_epidermal_layer | 0.48523919 |
| 102 | MP0008874_decreased_physiological_sensi | 0.48490417 |
| 103 | MP0000470_abnormal_stomach_morphology | 0.46975005 |
| 104 | MP0009278_abnormal_bone_marrow | 0.46735667 |
| 105 | MP0001986_abnormal_taste_sensitivity | 0.46325049 |
| 106 | MP0001663_abnormal_digestive_system | 0.46318285 |
| 107 | MP0000383_abnormal_hair_follicle | 0.46137606 |
| 108 | MP0005334_abnormal_fat_pad | 0.45984171 |
| 109 | MP0010094_abnormal_chromosome_stability | 0.44743459 |
| 110 | MP0000350_abnormal_cell_proliferation | 0.44718975 |
| 111 | MP0001765_abnormal_ion_homeostasis | 0.44685389 |
| 112 | MP0000249_abnormal_blood_vessel | 0.44278835 |
| 113 | MP0002136_abnormal_kidney_physiology | 0.43820041 |
| 114 | MP0005083_abnormal_biliary_tract | 0.43801049 |
| 115 | MP0005174_abnormal_tail_pigmentation | 0.43222151 |
| 116 | MP0003638_abnormal_response/metabolism_ | 0.42686455 |
| 117 | MP0005451_abnormal_body_composition | 0.42452620 |
| 118 | MP0008569_lethality_at_weaning | 0.42354012 |
| 119 | MP0009764_decreased_sensitivity_to | 0.41227664 |
| 120 | MP0003806_abnormal_nucleotide_metabolis | 0.40900819 |
| 121 | MP0002693_abnormal_pancreas_physiology | 0.40550812 |
| 122 | MP0005376_homeostasis/metabolism_phenot | 0.40120453 |
| 123 | MP0008007_abnormal_cellular_replicative | 0.39873206 |
| 124 | MP0002083_premature_death | 0.39016259 |
| 125 | MP0000367_abnormal_coat/_hair | 0.38997705 |
| 126 | MP0000313_abnormal_cell_death | 0.38978685 |
| 127 | MP0001191_abnormal_skin_condition | 0.38248801 |
| 128 | MP0003693_abnormal_embryo_hatching | 0.37529900 |
| 129 | MP0002132_abnormal_respiratory_system | 0.36494610 |
| 130 | MP0003091_abnormal_cell_migration | 0.35027457 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | T lymphocytopenia (HP:0005403) | 7.84745017 |
| 2 | Abnormality of T cell number (HP:0011839) | 7.65860258 |
| 3 | Severe combined immunodeficiency (HP:0004430) | 6.08825656 |
| 4 | Abnormality of T cells (HP:0002843) | 5.71429765 |
| 5 | Combined immunodeficiency (HP:0005387) | 5.71247745 |
| 6 | Recurrent bronchitis (HP:0002837) | 5.63885897 |
| 7 | Elevated erythrocyte sedimentation rate (HP:0003565) | 5.38773930 |
| 8 | Chronic otitis media (HP:0000389) | 5.38240642 |
| 9 | IgM deficiency (HP:0002850) | 5.04746604 |
| 10 | B lymphocytopenia (HP:0010976) | 5.02011558 |
| 11 | Abnormality of B cell number (HP:0010975) | 5.02011558 |
| 12 | Panhypogammaglobulinemia (HP:0003139) | 4.92656407 |
| 13 | IgG deficiency (HP:0004315) | 4.87429052 |
| 14 | Nasal polyposis (HP:0100582) | 4.73656930 |
| 15 | Stomatitis (HP:0010280) | 4.68821958 |
| 16 | Recurrent fungal infections (HP:0002841) | 4.59148536 |
| 17 | Recurrent bacterial skin infections (HP:0005406) | 4.57605998 |
| 18 | Recurrent viral infections (HP:0004429) | 4.51118258 |
| 19 | Eosinophilia (HP:0001880) | 4.47725125 |
| 20 | Autoimmune hemolytic anemia (HP:0001890) | 4.35545019 |
| 21 | Increased IgM level (HP:0003496) | 4.23346994 |
| 22 | Abnormality of macrophages (HP:0004311) | 4.19163475 |
| 23 | Eczematoid dermatitis (HP:0000976) | 4.18833399 |
| 24 | Abnormal delayed hypersensitivity skin test (HP:0002963) | 4.16232049 |
| 25 | Abnormality of eosinophils (HP:0001879) | 4.10234291 |
| 26 | Abnormality of the nasal mucosa (HP:0000433) | 3.89486198 |
| 27 | Abnormality of T cell physiology (HP:0011840) | 3.86828272 |
| 28 | Granulocytopenia (HP:0001913) | 3.84404876 |
| 29 | Abnormality of the fingertips (HP:0001211) | 3.83574431 |
| 30 | Lymphopenia (HP:0001888) | 3.67093956 |
| 31 | Abnormality of cells of the lymphoid lineage (HP:0012140) | 3.62079592 |
| 32 | Leukocytosis (HP:0001974) | 3.47897525 |
| 33 | Chronic mucocutaneous candidiasis (HP:0002728) | 3.46829917 |
| 34 | Recurrent cutaneous fungal infections (HP:0011370) | 3.46829917 |
| 35 | Myositis (HP:0100614) | 3.37815396 |
| 36 | Joint swelling (HP:0001386) | 3.37183560 |
| 37 | Hypochromic microcytic anemia (HP:0004840) | 3.36487057 |
| 38 | IgA deficiency (HP:0002720) | 3.33960502 |
| 39 | Recurrent gram-negative bacterial infections (HP:0005420) | 3.29343239 |
| 40 | Pustule (HP:0200039) | 3.24633067 |
| 41 | Bronchitis (HP:0012387) | 3.21114493 |
| 42 | Thyroiditis (HP:0100646) | 3.21075331 |
| 43 | Chronic diarrhea (HP:0002028) | 3.18694578 |
| 44 | Meningitis (HP:0001287) | 3.02994550 |
| 45 | Autoimmune thrombocytopenia (HP:0001973) | 2.94226163 |
| 46 | Hypergammaglobulinemia (HP:0010702) | 2.93612634 |
| 47 | Chronic sinusitis (HP:0011109) | 2.86647513 |
| 48 | Vasculitis (HP:0002633) | 2.85761242 |
| 49 | Hemoptysis (HP:0002105) | 2.80416068 |
| 50 | Recurrent sinusitis (HP:0011108) | 2.73969266 |
| 51 | Anorexia (HP:0002039) | 2.73032871 |
| 52 | Hypoplasia of the thymus (HP:0000778) | 2.70952274 |
| 53 | Encephalitis (HP:0002383) | 2.70452879 |
| 54 | Gingivitis (HP:0000230) | 2.68303961 |
| 55 | Obstructive lung disease (HP:0006536) | 2.65849945 |
| 56 | Chronic obstructive pulmonary disease (HP:0006510) | 2.65849945 |
| 57 | Gastrointestinal infarctions (HP:0005244) | 2.64816173 |
| 58 | Increased IgE level (HP:0003212) | 2.64409855 |
| 59 | Spontaneous hematomas (HP:0007420) | 2.64077581 |
| 60 | Basal cell carcinoma (HP:0002671) | 2.61000827 |
| 61 | Lymphoma (HP:0002665) | 2.60259020 |
| 62 | Pulmonary infiltrates (HP:0002113) | 2.59848098 |
| 63 | Slow saccadic eye movements (HP:0000514) | 2.59568691 |
| 64 | Urticaria (HP:0001025) | 2.54845882 |
| 65 | Ureteral stenosis (HP:0000071) | 2.40151752 |
| 66 | Chest pain (HP:0100749) | 2.39007511 |
| 67 | Recurrent otitis media (HP:0000403) | 2.35414717 |
| 68 | Pulmonary embolism (HP:0002204) | 2.34897348 |
| 69 | Cellulitis (HP:0100658) | 2.34798105 |
| 70 | Keratitis (HP:0000491) | 2.33294588 |
| 71 | Optic neuritis (HP:0100653) | 2.32091253 |
| 72 | Retrobulbar optic neuritis (HP:0100654) | 2.32091253 |
| 73 | Inflammation of the large intestine (HP:0002037) | 2.31344578 |
| 74 | Abnormal platelet volume (HP:0011876) | 2.31038807 |
| 75 | Abnormality of the pleura (HP:0002103) | 2.28879486 |
| 76 | Episodic fever (HP:0001954) | 2.28719803 |
| 77 | Gastrointestinal inflammation (HP:0004386) | 2.24987469 |
| 78 | Abnormality of the prostate (HP:0008775) | 2.23011135 |
| 79 | Papilloma (HP:0012740) | 2.22045383 |
| 80 | Verrucae (HP:0200043) | 2.22045383 |
| 81 | Thrombocytosis (HP:0001894) | 2.19691572 |
| 82 | Mediastinal lymphadenopathy (HP:0100721) | 2.16193022 |
| 83 | Ureteral obstruction (HP:0006000) | 2.14403634 |
| 84 | Emphysema (HP:0002097) | 2.12437622 |
| 85 | Papilledema (HP:0001085) | 2.11646316 |
| 86 | Stomach cancer (HP:0012126) | 2.09202035 |
| 87 | Sepsis (HP:0100806) | 2.07325413 |
| 88 | Hypoproteinemia (HP:0003075) | 2.06536176 |
| 89 | Toxemia of pregnancy (HP:0100603) | 2.04668003 |
| 90 | Agammaglobulinemia (HP:0004432) | 2.03609326 |
| 91 | Aplasia/Hypoplasia of the thymus (HP:0010515) | 2.02916328 |
| 92 | Recurrent skin infections (HP:0001581) | 2.00749226 |
| 93 | Keratoconjunctivitis sicca (HP:0001097) | 2.00122743 |
| 94 | Orchitis (HP:0100796) | 1.99801079 |
| 95 | Attenuation of retinal blood vessels (HP:0007843) | 1.97376438 |
| 96 | Recurrent abscess formation (HP:0002722) | 1.96164039 |
| 97 | Arterial thrombosis (HP:0004420) | 1.95778884 |
| 98 | Bronchiectasis (HP:0002110) | 1.94083631 |
| 99 | Glomerulopathy (HP:0100820) | 1.93878876 |
| 100 | Petechiae (HP:0000967) | 1.93688352 |
| 101 | Gangrene (HP:0100758) | 1.92353269 |
| 102 | Hepatitis (HP:0012115) | 1.91939079 |
| 103 | Abnormality of iron homeostasis (HP:0011031) | 1.91561684 |
| 104 | Cheilitis (HP:0100825) | 1.90667690 |
| 105 | Bicuspid aortic valve (HP:0001647) | 1.90431951 |
| 106 | Epistaxis (HP:0000421) | 1.89756695 |
| 107 | Colitis (HP:0002583) | 1.88419004 |
| 108 | Osteomyelitis (HP:0002754) | 1.83877095 |
| 109 | Gastrointestinal stroma tumor (HP:0100723) | 1.81915913 |
| 110 | Skin ulcer (HP:0200042) | 1.80301849 |
| 111 | Amaurosis fugax (HP:0100576) | 1.79218378 |
| 112 | Hypochromic anemia (HP:0001931) | 1.79017983 |
| 113 | Abnormality of the endocardium (HP:0004306) | 1.78289239 |
| 114 | Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204) | 1.77921456 |
| 115 | Periodontitis (HP:0000704) | 1.77709358 |
| 116 | Keratoconjunctivitis (HP:0001096) | 1.76850932 |
| 117 | Gingival bleeding (HP:0000225) | 1.75068959 |
| 118 | Increased mean platelet volume (HP:0011877) | 1.71955351 |
| 119 | Arthralgia (HP:0002829) | 1.67991064 |
| 120 | Increased density of long bones (HP:0006392) | 1.66415322 |
| 121 | Persistence of primary teeth (HP:0006335) | 1.65894314 |
| 122 | Prolonged bleeding time (HP:0003010) | 1.63517664 |
| 123 | Abnormality of the thymus (HP:0000777) | 1.61384971 |
| 124 | Acute hepatic failure (HP:0006554) | 1.60503418 |
| 125 | Microcytic anemia (HP:0001935) | 1.59835335 |
| 126 | Cellular immunodeficiency (HP:0005374) | 1.57545418 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | TXK | 6.94517872 |
| 2 | MAP4K1 | 5.25898926 |
| 3 | ZAP70 | 3.47023843 |
| 4 | FGFR4 | 3.32420531 |
| 5 | JAK3 | 3.04020108 |
| 6 | IKBKE | 3.01363589 |
| 7 | ITK | 2.93656728 |
| 8 | RIPK4 | 2.72790856 |
| 9 | TYK2 | 2.45236421 |
| 10 | STK10 | 2.39814438 |
| 11 | MAP3K12 | 2.38750020 |
| 12 | NLK | 2.29455883 |
| 13 | MAP3K10 | 2.28944067 |
| 14 | GRK6 | 2.27315983 |
| 15 | MST4 | 2.26114883 |
| 16 | FGFR3 | 2.10946742 |
| 17 | NME2 | 2.10172154 |
| 18 | LCK | 2.01965161 |
| 19 | TAOK3 | 1.99915598 |
| 20 | JAK1 | 1.98388017 |
| 21 | MAP3K14 | 1.85054193 |
| 22 | TBK1 | 1.62135385 |
| 23 | CSK | 1.57266862 |
| 24 | SYK | 1.55268286 |
| 25 | PRKCH | 1.55117211 |
| 26 | EEF2K | 1.53594269 |
| 27 | KDR | 1.49945048 |
| 28 | MAP3K11 | 1.48716461 |
| 29 | CAMKK1 | 1.48139885 |
| 30 | CAMKK2 | 1.46260942 |
| 31 | MAP2K3 | 1.45814668 |
| 32 | TEC | 1.43516887 |
| 33 | HCK | 1.42349688 |
| 34 | PKN2 | 1.36151417 |
| 35 | LRRK2 | 1.33241556 |
| 36 | ERN1 | 1.30251749 |
| 37 | TAOK2 | 1.25446296 |
| 38 | CLK1 | 1.17589055 |
| 39 | IKBKB | 1.14966629 |
| 40 | BTK | 1.14130214 |
| 41 | PRKCQ | 1.12700572 |
| 42 | CDK12 | 1.11611965 |
| 43 | MAP3K3 | 1.04691979 |
| 44 | JAK2 | 0.99278159 |
| 45 | KIT | 0.97069386 |
| 46 | BLK | 0.96028628 |
| 47 | PRPF4B | 0.92553090 |
| 48 | IRAK4 | 0.88635806 |
| 49 | MAP3K13 | 0.85155155 |
| 50 | MAP3K1 | 0.85134880 |
| 51 | TESK2 | 0.84643809 |
| 52 | FES | 0.84438839 |
| 53 | TNK2 | 0.83680681 |
| 54 | CHUK | 0.83357239 |
| 55 | SMG1 | 0.81385428 |
| 56 | PIM1 | 0.80391330 |
| 57 | MAP3K7 | 0.79584571 |
| 58 | PDGFRB | 0.78171759 |
| 59 | TRIB3 | 0.78029773 |
| 60 | MAP3K5 | 0.74407937 |
| 61 | CDK19 | 0.72898984 |
| 62 | PIK3CG | 0.71771036 |
| 63 | RPS6KA4 | 0.68962647 |
| 64 | EPHB1 | 0.67511516 |
| 65 | TYRO3 | 0.67491961 |
| 66 | LYN | 0.66646684 |
| 67 | ALK | 0.66529481 |
| 68 | MAPK11 | 0.64903975 |
| 69 | CDK4 | 0.63404666 |
| 70 | PDK1 | 0.61130553 |
| 71 | MARK3 | 0.60370891 |
| 72 | HIPK2 | 0.59246234 |
| 73 | FYN | 0.56919320 |
| 74 | INSR | 0.55949323 |
| 75 | SIK2 | 0.55610347 |
| 76 | ADRBK1 | 0.54818560 |
| 77 | EPHA3 | 0.54730535 |
| 78 | DYRK1B | 0.52775701 |
| 79 | PDPK1 | 0.51940387 |
| 80 | CDK6 | 0.51042941 |
| 81 | MAPKAPK3 | 0.49408104 |
| 82 | MARK2 | 0.48588354 |
| 83 | CSF1R | 0.48551253 |
| 84 | MAPK7 | 0.47882321 |
| 85 | RET | 0.47250521 |
| 86 | STK4 | 0.46754561 |
| 87 | RPS6KB2 | 0.46208333 |
| 88 | FGR | 0.44125653 |
| 89 | MELK | 0.43665999 |
| 90 | FGFR1 | 0.43201110 |
| 91 | YES1 | 0.42098147 |
| 92 | STK38 | 0.41981213 |
| 93 | PASK | 0.39648346 |
| 94 | MAPK4 | 0.39305041 |
| 95 | SIK1 | 0.39204751 |
| 96 | CDC7 | 0.38984102 |
| 97 | IRAK1 | 0.36527389 |
| 98 | PRKD2 | 0.36242950 |
| 99 | STK11 | 0.35193108 |
| 100 | PDK3 | 0.34703126 |
| 101 | PDK4 | 0.34703126 |
| 102 | IGF1R | 0.33631081 |
| 103 | TGFBR1 | 0.33082018 |
| 104 | GRK7 | 0.32234949 |
| 105 | TAOK1 | 0.31711539 |
| 106 | TTN | 0.31007802 |
| 107 | KSR2 | 0.29755700 |
| 108 | MAP2K6 | 0.29749730 |
| 109 | MAPK3 | 0.29056192 |
| 110 | NUAK1 | 0.28794892 |
| 111 | NEK6 | 0.28370866 |
| 112 | DMPK | 0.27387880 |
| 113 | FGFR2 | 0.25949111 |
| 114 | EGFR | 0.25887663 |
| 115 | RPS6KA5 | 0.25735561 |
| 116 | STK24 | 0.25696869 |
| 117 | DAPK1 | 0.24551255 |
| 118 | PTK6 | 0.24442903 |
| 119 | UHMK1 | 0.24036382 |
| 120 | PRKCD | 0.23809311 |
| 121 | NTRK2 | 0.23648918 |
| 122 | MAP3K8 | 0.23508761 |
| 123 | BRD4 | 0.21078147 |
| 124 | MAPK12 | 0.20613768 |
| 125 | TGFBR2 | 0.20593161 |
| 126 | ABL1 | 0.19719767 |
| 127 | RAF1 | 0.19357805 |
| 128 | SGK3 | 0.17606567 |
| 129 | RPS6KA6 | 0.16494659 |
| 130 | ACVR1B | 0.15655021 |
| 131 | MAPKAPK2 | 0.15540282 |
| 132 | MAPK9 | 0.15525203 |
| 133 | SIK3 | 0.15440801 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Primary immunodeficiency_Homo sapiens_hsa05340 | 6.62995188 |
| 2 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 4.65142010 |
| 3 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 3.66270318 |
| 4 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 3.01382133 |
| 5 | Measles_Homo sapiens_hsa05162 | 2.97415963 |
| 6 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 2.87595482 |
| 7 | Allograft rejection_Homo sapiens_hsa05330 | 2.78441215 |
| 8 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 2.65477122 |
| 9 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 2.54852568 |
| 10 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 2.07609666 |
| 11 | Antigen processing and presentation_Homo sapiens_hsa04612 | 2.01061512 |
| 12 | Ribosome_Homo sapiens_hsa03010 | 1.94237627 |
| 13 | Viral myocarditis_Homo sapiens_hsa05416 | 1.90586671 |
| 14 | Graft-versus-host disease_Homo sapiens_hsa05332 | 1.87940656 |
| 15 | Leishmaniasis_Homo sapiens_hsa05140 | 1.80026244 |
| 16 | Osteoclast differentiation_Homo sapiens_hsa04380 | 1.76715639 |
| 17 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 1.59253114 |
| 18 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 1.51328235 |
| 19 | Herpes simplex infection_Homo sapiens_hsa05168 | 1.49498260 |
| 20 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 1.47783999 |
| 21 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 1.41333569 |
| 22 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 1.39714267 |
| 23 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 1.35937035 |
| 24 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 1.35028033 |
| 25 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.34225286 |
| 26 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 1.30430022 |
| 27 | Asthma_Homo sapiens_hsa05310 | 1.28022937 |
| 28 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 1.24843092 |
| 29 | Shigellosis_Homo sapiens_hsa05131 | 1.24245229 |
| 30 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 1.23404285 |
| 31 | HTLV-I infection_Homo sapiens_hsa05166 | 1.20002688 |
| 32 | Hepatitis B_Homo sapiens_hsa05161 | 1.19256591 |
| 33 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 1.18826193 |
| 34 | Toxoplasmosis_Homo sapiens_hsa05145 | 1.18330048 |
| 35 | African trypanosomiasis_Homo sapiens_hsa05143 | 1.11066895 |
| 36 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.09343778 |
| 37 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 1.03277997 |
| 38 | Colorectal cancer_Homo sapiens_hsa05210 | 1.01069066 |
| 39 | Influenza A_Homo sapiens_hsa05164 | 0.98546515 |
| 40 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.96659715 |
| 41 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.91654743 |
| 42 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.90418949 |
| 43 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.90342511 |
| 44 | Apoptosis_Homo sapiens_hsa04210 | 0.86824420 |
| 45 | Spliceosome_Homo sapiens_hsa03040 | 0.85802774 |
| 46 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.85800749 |
| 47 | TNF signaling pathway_Homo sapiens_hsa04668 | 0.85437937 |
| 48 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.84379441 |
| 49 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.83836228 |
| 50 | Platelet activation_Homo sapiens_hsa04611 | 0.82385105 |
| 51 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.81730017 |
| 52 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.79974455 |
| 53 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.79413435 |
| 54 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.78691026 |
| 55 | Phototransduction_Homo sapiens_hsa04744 | 0.75877647 |
| 56 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 0.75209603 |
| 57 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.74410349 |
| 58 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 0.69047025 |
| 59 | Legionellosis_Homo sapiens_hsa05134 | 0.68671542 |
| 60 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.67849665 |
| 61 | Thyroid cancer_Homo sapiens_hsa05216 | 0.67800144 |
| 62 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.66844737 |
| 63 | Hepatitis C_Homo sapiens_hsa05160 | 0.64595898 |
| 64 | Salmonella infection_Homo sapiens_hsa05132 | 0.64020830 |
| 65 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.58859150 |
| 66 | Tuberculosis_Homo sapiens_hsa05152 | 0.58377294 |
| 67 | Phagosome_Homo sapiens_hsa04145 | 0.57858713 |
| 68 | Circadian rhythm_Homo sapiens_hsa04710 | 0.55155402 |
| 69 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.54583167 |
| 70 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.52671249 |
| 71 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.51204745 |
| 72 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.49632236 |
| 73 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.48050089 |
| 74 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.47234355 |
| 75 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.46969764 |
| 76 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.46925491 |
| 77 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.45991072 |
| 78 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.45478075 |
| 79 | Pertussis_Homo sapiens_hsa05133 | 0.45113570 |
| 80 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.44811951 |
| 81 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.44588931 |
| 82 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.44001564 |
| 83 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.41378910 |
| 84 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.40787109 |
| 85 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.40651036 |
| 86 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.40639250 |
| 87 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.38530799 |
| 88 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.38147084 |
| 89 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.37958925 |
| 90 | DNA replication_Homo sapiens_hsa03030 | 0.37923154 |
| 91 | Malaria_Homo sapiens_hsa05144 | 0.37701535 |
| 92 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.36425589 |
| 93 | Adherens junction_Homo sapiens_hsa04520 | 0.35871455 |
| 94 | Prostate cancer_Homo sapiens_hsa05215 | 0.35627572 |
| 95 | Endometrial cancer_Homo sapiens_hsa05213 | 0.34540127 |
| 96 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.33688644 |
| 97 | Endocytosis_Homo sapiens_hsa04144 | 0.33645216 |
| 98 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.33485065 |
| 99 | RNA degradation_Homo sapiens_hsa03018 | 0.33163620 |
| 100 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.32653900 |
| 101 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.32564504 |
| 102 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.32200053 |
| 103 | Base excision repair_Homo sapiens_hsa03410 | 0.31967276 |
| 104 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.31731079 |
| 105 | Mismatch repair_Homo sapiens_hsa03430 | 0.31272822 |
| 106 | Long-term potentiation_Homo sapiens_hsa04720 | 0.31259160 |
| 107 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 0.31090580 |
| 108 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.29475007 |
| 109 | Other glycan degradation_Homo sapiens_hsa00511 | 0.29201716 |
| 110 | Lysine degradation_Homo sapiens_hsa00310 | 0.27645835 |
| 111 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.26518928 |
| 112 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.25962264 |
| 113 | GnRH signaling pathway_Homo sapiens_hsa04912 | 0.25761091 |
| 114 | Proteasome_Homo sapiens_hsa03050 | 0.24181946 |
| 115 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.24059578 |
| 116 | Cell cycle_Homo sapiens_hsa04110 | 0.23943111 |
| 117 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.23637618 |
| 118 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.23469286 |
| 119 | Insulin resistance_Homo sapiens_hsa04931 | 0.22395248 |
| 120 | RNA transport_Homo sapiens_hsa03013 | 0.21034749 |
| 121 | Pathways in cancer_Homo sapiens_hsa05200 | 0.19977569 |
| 122 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.19120278 |
| 123 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.19003540 |
| 124 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.18752724 |

