TRBV19

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative T cell selection (GO:0043383)8.85169969
2positive regulation of gamma-delta T cell activation (GO:0046645)8.39709308
3negative thymic T cell selection (GO:0045060)8.32937520
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)8.15719352
5antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)8.15719352
6positive T cell selection (GO:0043368)8.04714450
7positive thymic T cell selection (GO:0045059)7.66503629
8positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)7.48643817
9regulation of gamma-delta T cell differentiation (GO:0045586)7.16578542
10thymic T cell selection (GO:0045061)7.11842827
11T cell selection (GO:0045058)7.05249501
12antigen processing and presentation of endogenous antigen (GO:0019883)6.77380992
13negative regulation of cell killing (GO:0031342)6.64323186
14negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.64323186
15regulation of gamma-delta T cell activation (GO:0046643)6.44002531
16positive regulation of interleukin-2 biosynthetic process (GO:0045086)6.37609166
17regulation of isotype switching to IgG isotypes (GO:0048302)6.26201437
18T cell receptor signaling pathway (GO:0050852)5.99122061
19leukocyte aggregation (GO:0070486)5.74028242
20interferon-gamma production (GO:0032609)5.67271002
21T cell migration (GO:0072678)5.50787388
22response to interleukin-15 (GO:0070672)5.48480874
23T cell costimulation (GO:0031295)5.47714748
24lymphocyte costimulation (GO:0031294)5.40601433
25tolerance induction (GO:0002507)5.37957915
26production of molecular mediator involved in inflammatory response (GO:0002532)5.34766519
27cellular response to interleukin-15 (GO:0071350)5.18030929
28regulation of T cell tolerance induction (GO:0002664)5.12694678
29regulation of regulatory T cell differentiation (GO:0045589)5.04358971
30regulation of T cell receptor signaling pathway (GO:0050856)4.92056761
31antigen receptor-mediated signaling pathway (GO:0050851)4.87414450
32regulation of antigen receptor-mediated signaling pathway (GO:0050854)4.69036883
33regulation of alpha-beta T cell proliferation (GO:0046640)4.66816606
34regulation of interleukin-12 biosynthetic process (GO:0045075)4.65659740
35regulation of interleukin-2 biosynthetic process (GO:0045076)4.56432736
36regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.43936383
37negative regulation of lymphocyte mediated immunity (GO:0002707)4.42108358
38positive regulation of interleukin-2 production (GO:0032743)4.35857916
39positive regulation of alpha-beta T cell proliferation (GO:0046641)4.34571762
40mast cell activation (GO:0045576)4.32295651
41regulation of B cell receptor signaling pathway (GO:0050855)4.24240259
42V(D)J recombination (GO:0033151)4.22071795
43activated T cell proliferation (GO:0050798)4.15969836
44cell wall macromolecule metabolic process (GO:0044036)4.12784354
45positive regulation of tolerance induction (GO:0002645)4.12713974
46T cell differentiation (GO:0030217)4.10222208
47alpha-beta T cell differentiation (GO:0046632)3.94142803
48positive regulation of humoral immune response (GO:0002922)3.93251140
49positive regulation of interleukin-4 production (GO:0032753)3.87736694
50alpha-beta T cell activation (GO:0046631)3.86587993
51regulation of T cell mediated cytotoxicity (GO:0001914)3.75989218
52positive regulation of chemokine secretion (GO:0090197)3.73518077
53regulation of B cell differentiation (GO:0045577)3.69758611
54regulation of isotype switching (GO:0045191)3.69646403
55positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.67158004
56positive regulation of natural killer cell mediated immunity (GO:0002717)3.67158004
57positive regulation of T cell mediated cytotoxicity (GO:0001916)3.66966539
58negative regulation of leukocyte mediated immunity (GO:0002704)3.65907484
59T cell differentiation involved in immune response (GO:0002292)3.64751939
60alpha-beta T cell differentiation involved in immune response (GO:0002293)3.64751939
61alpha-beta T cell activation involved in immune response (GO:0002287)3.64751939
62positive regulation of isotype switching (GO:0045830)3.61733758
63T cell activation (GO:0042110)3.60618974
64regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.60080543
65regulation of defense response to virus by virus (GO:0050690)3.59083553
66regulation of natural killer cell mediated immunity (GO:0002715)3.58743986
67regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.58743986
68regulation of tolerance induction (GO:0002643)3.57231777
69antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.56580908
70positive regulation of B cell differentiation (GO:0045579)3.55489848
71regulation of immunoglobulin production (GO:0002637)3.54320756
72antigen processing and presentation via MHC class Ib (GO:0002475)3.54051901
73negative regulation of T cell receptor signaling pathway (GO:0050860)3.53637275
74negative regulation of T cell mediated immunity (GO:0002710)3.51783087
75regulation of response to interferon-gamma (GO:0060330)3.51274503
76detection of bacterium (GO:0016045)3.49581263
77positive regulation of immunoglobulin production (GO:0002639)3.49122912
78CD4-positive, alpha-beta T cell differentiation (GO:0043367)3.48187228
79positive regulation by symbiont of host defense response (GO:0052509)3.48156475
80modulation by symbiont of host defense response (GO:0052031)3.48156475
81modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.48156475
82modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.48156475
83positive regulation by organism of defense response of other organism involved in symbiotic interact3.48156475
84modulation by symbiont of host immune response (GO:0052553)3.48156475
85detection of other organism (GO:0098543)3.42109342
86T cell homeostasis (GO:0043029)3.40882481
87tumor necrosis factor-mediated signaling pathway (GO:0033209)3.40389353
88regulation of immunoglobulin secretion (GO:0051023)3.39029843
89cellular response to type I interferon (GO:0071357)3.38563139
90type I interferon signaling pathway (GO:0060337)3.38563139
91negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.37739934
92positive regulation of granulocyte differentiation (GO:0030854)3.36822408
93immune response-activating cell surface receptor signaling pathway (GO:0002429)3.36175796
94regulation of chemokine secretion (GO:0090196)3.35661188
95response to type I interferon (GO:0034340)3.35142092
96regulation of immunoglobulin mediated immune response (GO:0002889)3.35134642
97positive regulation of B cell mediated immunity (GO:0002714)3.34306325
98positive regulation of immunoglobulin mediated immune response (GO:0002891)3.34306325
99regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.32410393
100negative regulation of interleukin-12 production (GO:0032695)3.30715784
101cellular response to interleukin-4 (GO:0071353)3.28584695
102viral transcription (GO:0019083)3.26803767
103interferon-gamma secretion (GO:0072643)3.25967109
104dendritic cell chemotaxis (GO:0002407)3.24840625
105regulation of histone H3-K27 methylation (GO:0061085)3.22025395
106cellular defense response (GO:0006968)3.21959464
107regulation of B cell mediated immunity (GO:0002712)3.21921561
108CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.21155462
109T-helper cell differentiation (GO:0042093)3.21155462
110T cell proliferation (GO:0042098)3.19729600
111positive regulation of T cell activation (GO:0050870)3.19116920
112regulation of interleukin-2 production (GO:0032663)3.18963959
113NIK/NF-kappaB signaling (GO:0038061)3.16985425
114positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.16835139
115cellular extravasation (GO:0045123)3.15719728
116leukocyte cell-cell adhesion (GO:0007159)3.13810178
117positive regulation of DNA recombination (GO:0045911)3.13686730
118regulation of leukocyte mediated cytotoxicity (GO:0001910)3.12186507
119positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.11467893
120negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.11119478
121translational termination (GO:0006415)3.11004937
122negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.10113330
123JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.09943126
124CD4-positive, alpha-beta T cell activation (GO:0035710)3.08961141
125regulation of alpha-beta T cell activation (GO:0046634)3.06796468
126natural killer cell activation (GO:0030101)3.06544751
127regulation of cell killing (GO:0031341)3.06532978
128positive regulation of T cell differentiation in thymus (GO:0033089)3.04985416
129sequestering of actin monomers (GO:0042989)3.04660425
130respiratory burst (GO:0045730)3.04594288
131neutrophil activation involved in immune response (GO:0002283)3.04387583
132mucosal-associated lymphoid tissue development (GO:0048537)3.03854756
133Peyers patch development (GO:0048541)3.03854756
134negative regulation of adaptive immune response (GO:0002820)3.02413694
135dendritic cell migration (GO:0036336)3.02111398
136regulation of type I interferon-mediated signaling pathway (GO:0060338)3.00690997
137positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.98820184
138response to interleukin-4 (GO:0070670)2.95424088
139lymphocyte migration (GO:0072676)2.95208636
140regulation of T cell activation (GO:0050863)2.94803069
141regulation of interleukin-4 production (GO:0032673)2.92398756
142mast cell degranulation (GO:0043303)2.92098029
143mast cell activation involved in immune response (GO:0002279)2.92098029

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse9.23588153
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human6.08116526
3RUNX_20019798_ChIP-Seq_JUKART_Human4.04010634
4STAT3_20064451_ChIP-Seq_CD4+T_Mouse4.03603430
5MYC_22102868_ChIP-Seq_BL_Human3.83901262
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.83462809
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.71186503
8STAT4_19710469_ChIP-ChIP_TH1__Mouse3.62062816
9FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.61845386
10IRF8_22096565_ChIP-ChIP_GC-B_Human3.50318107
11MYB_26560356_Chip-Seq_TH2_Human3.44254559
12EGR1_19374776_ChIP-ChIP_THP-1_Human3.34331644
13E2F7_22180533_ChIP-Seq_HELA_Human3.30830486
14MAF_26560356_Chip-Seq_TH1_Human3.14628878
15UTX_26944678_Chip-Seq_JUKART_Human2.99843148
16MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.75120720
17MYB_26560356_Chip-Seq_TH1_Human2.69940802
18NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.46339700
19NOTCH1_21737748_ChIP-Seq_TLL_Human2.46319247
20SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.45819584
21KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.27568545
22MAF_26560356_Chip-Seq_TH2_Human2.25372747
23GATA3_27048872_Chip-Seq_THYMUS_Human2.23948656
24VDR_21846776_ChIP-Seq_THP-1_Human2.23206731
25TCF7_22412390_ChIP-Seq_EML_Mouse2.09615055
26RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.00382394
27FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.96392315
28IRF8_21731497_ChIP-ChIP_J774_Mouse1.88976354
29SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.86491100
30KDM2B_26808549_Chip-Seq_DND41_Human1.83860824
31KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.83155793
32RUNX1_22412390_ChIP-Seq_EML_Mouse1.76068229
33E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.75316325
34SCL_19346495_ChIP-Seq_HPC-7_Human1.68703027
35VDR_24763502_ChIP-Seq_THP-1_Human1.66542419
36SPI1_23547873_ChIP-Seq_NB4_Human1.65466837
37NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.61605004
38SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.58011524
39MYB_21317192_ChIP-Seq_ERMYB_Mouse1.57320724
40RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.56757715
41ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.54871177
42EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.54433358
43BP1_19119308_ChIP-ChIP_Hs578T_Human1.52815121
44STAT6_21828071_ChIP-Seq_BEAS2B_Human1.50218740
45CIITA_25753668_ChIP-Seq_RAJI_Human1.47277934
46ELF1_17652178_ChIP-ChIP_JURKAT_Human1.47226507
47RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.41896069
48TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.40486190
49FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.39099882
50MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.36371197
51IRF8_27001747_Chip-Seq_BMDM_Mouse1.36201422
52VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.33941880
53BRD4_27068464_Chip-Seq_AML-cells_Mouse1.31387434
54SPI1_23127762_ChIP-Seq_K562_Human1.28979727
55FOXM1_23109430_ChIP-Seq_U2OS_Human1.26598950
56HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.26011772
57KDM2B_26808549_Chip-Seq_SUP-B15_Human1.25571510
58KDM2B_26808549_Chip-Seq_JURKAT_Human1.24256865
59VDR_24787735_ChIP-Seq_THP-1_Human1.24102166
60BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.22938761
61GATA3_26560356_Chip-Seq_TH2_Human1.22604689
62SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.17104326
63E2F4_17652178_ChIP-ChIP_JURKAT_Human1.14392969
64PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.13193544
65VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.13079150
66GATA2_22383799_ChIP-Seq_G1ME_Mouse1.12007158
67VDR_23849224_ChIP-Seq_CD4+_Human1.10424740
68BCL6_27268052_Chip-Seq_Bcells_Human1.10395101
69CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10227296
70PU_27001747_Chip-Seq_BMDM_Mouse1.09009556
71SMAD_19615063_ChIP-ChIP_OVARY_Human1.08656088
72GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07952347
73FOXP3_21729870_ChIP-Seq_TREG_Human1.06294976
74PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06035389
75ELK3_25401928_ChIP-Seq_HUVEC_Human1.05524985
76SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99764932
77TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.97804971
78SMRT_27268052_Chip-Seq_Bcells_Human0.97545368
79GATA1_22025678_ChIP-Seq_K562_Human0.97311237
80Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.95163099
81BCOR_27268052_Chip-Seq_Bcells_Human0.93449436
82SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.92611523
83GATA3_26560356_Chip-Seq_TH1_Human0.91894823
84TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91852948
85ELK1_19687146_ChIP-ChIP_HELA_Human0.89389867
86ERG_20887958_ChIP-Seq_HPC-7_Mouse0.89133288
87GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.86483960
88GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84629216
89PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.84406707
90CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.83621924
91CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.83374262
92PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.82881067
93GATA2_21666600_ChIP-Seq_HMVEC_Human0.82544534
94ELF1_20517297_ChIP-Seq_JURKAT_Human0.81853151
95NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.81376653
96GATA1_22383799_ChIP-Seq_G1ME_Mouse0.80950850
97P300_27268052_Chip-Seq_Bcells_Human0.80430545
98BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.78049992
99NCOR1_26117541_ChIP-Seq_K562_Human0.77487756
100RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77375462
101CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.77080376
102XRN2_22483619_ChIP-Seq_HELA_Human0.76815135
103NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.76156186
104PU.1_20513432_ChIP-Seq_Bcells_Mouse0.75116563
105SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.73819169
106MYC_19079543_ChIP-ChIP_MESCs_Mouse0.73115046
107HOXB4_20404135_ChIP-ChIP_EML_Mouse0.72180051
108RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.71186695
109FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.71129375
110LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.70552264
111GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.66997824
112GATA1_19941826_ChIP-Seq_K562_Human0.65993293
113ETS1_22383799_ChIP-Seq_G1ME_Mouse0.64201430
114KDM5A_27292631_Chip-Seq_BREAST_Human0.63842418
115LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.61393358
116NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.61342201
117STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.60598332
118TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.58408724
119CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.57824523
120GATA1_19941827_ChIP-Seq_MEL_Mouse0.56903069
121FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.56471405

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology6.47816857
2MP0005671_abnormal_response_to4.51531260
3MP0000685_abnormal_immune_system3.75079865
4MP0002166_altered_tumor_susceptibility3.45412243
5MP0009333_abnormal_splenocyte_physiolog3.30363202
6MP0001835_abnormal_antigen_presentation3.14267386
7MP0000703_abnormal_thymus_morphology3.10692284
8MP0001800_abnormal_humoral_immune2.97854912
9MP0002398_abnormal_bone_marrow2.95621070
10MP0002420_abnormal_adaptive_immunity2.87528658
11MP0005000_abnormal_immune_tolerance2.85783421
12MP0001819_abnormal_immune_cell2.84191192
13MP0001790_abnormal_immune_system2.77011675
14MP0005387_immune_system_phenotype2.77011675
15MP0002006_tumorigenesis2.75124913
16MP0002723_abnormal_immune_serum2.66408437
17MP0003300_gastrointestinal_ulcer2.64596527
18MP0003724_increased_susceptibility_to2.63038650
19MP0000716_abnormal_immune_system2.56786226
20MP0002722_abnormal_immune_system2.43906094
21MP0002452_abnormal_antigen_presenting2.42302216
22MP0003436_decreased_susceptibility_to2.40915385
23MP0009785_altered_susceptibility_to2.38392475
24MP0002405_respiratory_system_inflammati2.37004262
25MP0003866_abnormal_defecation2.28486717
26MP0005025_abnormal_response_to2.27227564
27MP0000689_abnormal_spleen_morphology2.27139808
28MP0001873_stomach_inflammation2.23079505
29MP0010155_abnormal_intestine_physiology2.22442665
30MP0002933_joint_inflammation2.21575329
31MP0004947_skin_inflammation2.20334671
32MP0002396_abnormal_hematopoietic_system2.09306978
33MP0002429_abnormal_blood_cell2.06134240
34MP0004381_abnormal_hair_follicle2.04914805
35MP0002148_abnormal_hypersensitivity_rea1.90624094
36MP0001853_heart_inflammation1.85753515
37MP0006082_CNS_inflammation1.84590232
38MP0003303_peritoneal_inflammation1.83252106
39MP0004510_myositis1.76326935
40MP0002277_abnormal_respiratory_mucosa1.70107556
41MP0004808_abnormal_hematopoietic_stem1.68005877
42MP0001845_abnormal_inflammatory_respons1.62570438
43MP0002419_abnormal_innate_immunity1.55135275
44MP0005310_abnormal_salivary_gland1.45737252
45MP0002163_abnormal_gland_morphology1.35853736
46MP0000858_altered_metastatic_potential1.34651438
47MP0005464_abnormal_platelet_physiology1.33399541
48MP0005075_abnormal_melanosome_morpholog1.23807392
49MP0002009_preneoplasia1.14624783
50MP0001545_abnormal_hematopoietic_system1.13679317
51MP0005397_hematopoietic_system_phenotyp1.13679317
52MP0003448_altered_tumor_morphology1.13327945
53MP0000490_abnormal_crypts_of1.12299278
54MP0000465_gastrointestinal_hemorrhage1.09915609
55MP0008260_abnormal_autophagy1.07941082
56MP0001533_abnormal_skeleton_physiology1.05797212
57MP0002822_catalepsy1.05202435
58MP0003172_abnormal_lysosome_physiology1.03260610
59MP0002019_abnormal_tumor_incidence0.96940174
60MP0008469_abnormal_protein_level0.96757624
61MP0008057_abnormal_DNA_replication0.95536424
62MP0002998_abnormal_bone_remodeling0.94640992
63MP0005023_abnormal_wound_healing0.92905649
64MP0003828_pulmonary_edema0.91241705
65MP0005076_abnormal_cell_differentiation0.87201400
66MP0001851_eye_inflammation0.87195379
67MP0004883_abnormal_blood_vessel0.84854967
68MP0003191_abnormal_cellular_cholesterol0.81026780
69MP0009765_abnormal_xenobiotic_induced0.80833559
70MP0001348_abnormal_lacrimal_gland0.76321413
71MP0009763_increased_sensitivity_to0.75796985
72MP0003077_abnormal_cell_cycle0.74444395
73MP0005381_digestive/alimentary_phenotyp0.71921022
74MP0008961_abnormal_basal_metabolism0.71749873
75MP0004130_abnormal_muscle_cell0.71457896
76MP0010352_gastrointestinal_tract_polyps0.70822743
77MP0008872_abnormal_physiological_respon0.68700127
78MP0003878_abnormal_ear_physiology0.68358037
79MP0005377_hearing/vestibular/ear_phenot0.68358037
80MP0005164_abnormal_response_to0.65789496
81MP0001243_abnormal_dermal_layer0.65493090
82MP0003795_abnormal_bone_structure0.65133573
83MP0003787_abnormal_imprinting0.64693181
84MP0000609_abnormal_liver_physiology0.62795344
85MP0000477_abnormal_intestine_morphology0.60122250
86MP0005166_decreased_susceptibility_to0.59765930
87MP0005390_skeleton_phenotype0.59203095
88MP0002138_abnormal_hepatobiliary_system0.58462039
89MP0004957_abnormal_blastocyst_morpholog0.57342750
90MP0002127_abnormal_cardiovascular_syste0.57244525
91MP0005379_endocrine/exocrine_gland_phen0.54642888
92MP0001764_abnormal_homeostasis0.54002028
93MP0003453_abnormal_keratinocyte_physiol0.53743438
94MP0010234_abnormal_vibrissa_follicle0.53448051
95MP0003045_fibrosis0.52931269
96MP0003646_muscle_fatigue0.52560789
97MP0003221_abnormal_cardiomyocyte_apopto0.52553786
98MP0008877_abnormal_DNA_methylation0.51762483
99MP0000604_amyloidosis0.49278073
100MP0008873_increased_physiological_sensi0.48919975
101MP0001216_abnormal_epidermal_layer0.48523919
102MP0008874_decreased_physiological_sensi0.48490417
103MP0000470_abnormal_stomach_morphology0.46975005
104MP0009278_abnormal_bone_marrow0.46735667
105MP0001986_abnormal_taste_sensitivity0.46325049
106MP0001663_abnormal_digestive_system0.46318285
107MP0000383_abnormal_hair_follicle0.46137606
108MP0005334_abnormal_fat_pad0.45984171
109MP0010094_abnormal_chromosome_stability0.44743459
110MP0000350_abnormal_cell_proliferation0.44718975
111MP0001765_abnormal_ion_homeostasis0.44685389
112MP0000249_abnormal_blood_vessel0.44278835
113MP0002136_abnormal_kidney_physiology0.43820041
114MP0005083_abnormal_biliary_tract0.43801049
115MP0005174_abnormal_tail_pigmentation0.43222151
116MP0003638_abnormal_response/metabolism_0.42686455
117MP0005451_abnormal_body_composition0.42452620
118MP0008569_lethality_at_weaning0.42354012
119MP0009764_decreased_sensitivity_to0.41227664
120MP0003806_abnormal_nucleotide_metabolis0.40900819
121MP0002693_abnormal_pancreas_physiology0.40550812
122MP0005376_homeostasis/metabolism_phenot0.40120453
123MP0008007_abnormal_cellular_replicative0.39873206
124MP0002083_premature_death0.39016259
125MP0000367_abnormal_coat/_hair0.38997705
126MP0000313_abnormal_cell_death0.38978685
127MP0001191_abnormal_skin_condition0.38248801
128MP0003693_abnormal_embryo_hatching0.37529900
129MP0002132_abnormal_respiratory_system0.36494610
130MP0003091_abnormal_cell_migration0.35027457

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)7.84745017
2Abnormality of T cell number (HP:0011839)7.65860258
3Severe combined immunodeficiency (HP:0004430)6.08825656
4Abnormality of T cells (HP:0002843)5.71429765
5Combined immunodeficiency (HP:0005387)5.71247745
6Recurrent bronchitis (HP:0002837)5.63885897
7Elevated erythrocyte sedimentation rate (HP:0003565)5.38773930
8Chronic otitis media (HP:0000389)5.38240642
9IgM deficiency (HP:0002850)5.04746604
10B lymphocytopenia (HP:0010976)5.02011558
11Abnormality of B cell number (HP:0010975)5.02011558
12Panhypogammaglobulinemia (HP:0003139)4.92656407
13IgG deficiency (HP:0004315)4.87429052
14Nasal polyposis (HP:0100582)4.73656930
15Stomatitis (HP:0010280)4.68821958
16Recurrent fungal infections (HP:0002841)4.59148536
17Recurrent bacterial skin infections (HP:0005406)4.57605998
18Recurrent viral infections (HP:0004429)4.51118258
19Eosinophilia (HP:0001880)4.47725125
20Autoimmune hemolytic anemia (HP:0001890)4.35545019
21Increased IgM level (HP:0003496)4.23346994
22Abnormality of macrophages (HP:0004311)4.19163475
23Eczematoid dermatitis (HP:0000976)4.18833399
24Abnormal delayed hypersensitivity skin test (HP:0002963)4.16232049
25Abnormality of eosinophils (HP:0001879)4.10234291
26Abnormality of the nasal mucosa (HP:0000433)3.89486198
27Abnormality of T cell physiology (HP:0011840)3.86828272
28Granulocytopenia (HP:0001913)3.84404876
29Abnormality of the fingertips (HP:0001211)3.83574431
30Lymphopenia (HP:0001888)3.67093956
31Abnormality of cells of the lymphoid lineage (HP:0012140)3.62079592
32Leukocytosis (HP:0001974)3.47897525
33Chronic mucocutaneous candidiasis (HP:0002728)3.46829917
34Recurrent cutaneous fungal infections (HP:0011370)3.46829917
35Myositis (HP:0100614)3.37815396
36Joint swelling (HP:0001386)3.37183560
37Hypochromic microcytic anemia (HP:0004840)3.36487057
38IgA deficiency (HP:0002720)3.33960502
39Recurrent gram-negative bacterial infections (HP:0005420)3.29343239
40Pustule (HP:0200039)3.24633067
41Bronchitis (HP:0012387)3.21114493
42Thyroiditis (HP:0100646)3.21075331
43Chronic diarrhea (HP:0002028)3.18694578
44Meningitis (HP:0001287)3.02994550
45Autoimmune thrombocytopenia (HP:0001973)2.94226163
46Hypergammaglobulinemia (HP:0010702)2.93612634
47Chronic sinusitis (HP:0011109)2.86647513
48Vasculitis (HP:0002633)2.85761242
49Hemoptysis (HP:0002105)2.80416068
50Recurrent sinusitis (HP:0011108)2.73969266
51Anorexia (HP:0002039)2.73032871
52Hypoplasia of the thymus (HP:0000778)2.70952274
53Encephalitis (HP:0002383)2.70452879
54Gingivitis (HP:0000230)2.68303961
55Obstructive lung disease (HP:0006536)2.65849945
56Chronic obstructive pulmonary disease (HP:0006510)2.65849945
57Gastrointestinal infarctions (HP:0005244)2.64816173
58Increased IgE level (HP:0003212)2.64409855
59Spontaneous hematomas (HP:0007420)2.64077581
60Basal cell carcinoma (HP:0002671)2.61000827
61Lymphoma (HP:0002665)2.60259020
62Pulmonary infiltrates (HP:0002113)2.59848098
63Slow saccadic eye movements (HP:0000514)2.59568691
64Urticaria (HP:0001025)2.54845882
65Ureteral stenosis (HP:0000071)2.40151752
66Chest pain (HP:0100749)2.39007511
67Recurrent otitis media (HP:0000403)2.35414717
68Pulmonary embolism (HP:0002204)2.34897348
69Cellulitis (HP:0100658)2.34798105
70Keratitis (HP:0000491)2.33294588
71Optic neuritis (HP:0100653)2.32091253
72Retrobulbar optic neuritis (HP:0100654)2.32091253
73Inflammation of the large intestine (HP:0002037)2.31344578
74Abnormal platelet volume (HP:0011876)2.31038807
75Abnormality of the pleura (HP:0002103)2.28879486
76Episodic fever (HP:0001954)2.28719803
77Gastrointestinal inflammation (HP:0004386)2.24987469
78Abnormality of the prostate (HP:0008775)2.23011135
79Papilloma (HP:0012740)2.22045383
80Verrucae (HP:0200043)2.22045383
81Thrombocytosis (HP:0001894)2.19691572
82Mediastinal lymphadenopathy (HP:0100721)2.16193022
83Ureteral obstruction (HP:0006000)2.14403634
84Emphysema (HP:0002097)2.12437622
85Papilledema (HP:0001085)2.11646316
86Stomach cancer (HP:0012126)2.09202035
87Sepsis (HP:0100806)2.07325413
88Hypoproteinemia (HP:0003075)2.06536176
89Toxemia of pregnancy (HP:0100603)2.04668003
90Agammaglobulinemia (HP:0004432)2.03609326
91Aplasia/Hypoplasia of the thymus (HP:0010515)2.02916328
92Recurrent skin infections (HP:0001581)2.00749226
93Keratoconjunctivitis sicca (HP:0001097)2.00122743
94Orchitis (HP:0100796)1.99801079
95Attenuation of retinal blood vessels (HP:0007843)1.97376438
96Recurrent abscess formation (HP:0002722)1.96164039
97Arterial thrombosis (HP:0004420)1.95778884
98Bronchiectasis (HP:0002110)1.94083631
99Glomerulopathy (HP:0100820)1.93878876
100Petechiae (HP:0000967)1.93688352
101Gangrene (HP:0100758)1.92353269
102Hepatitis (HP:0012115)1.91939079
103Abnormality of iron homeostasis (HP:0011031)1.91561684
104Cheilitis (HP:0100825)1.90667690
105Bicuspid aortic valve (HP:0001647)1.90431951
106Epistaxis (HP:0000421)1.89756695
107Colitis (HP:0002583)1.88419004
108Osteomyelitis (HP:0002754)1.83877095
109Gastrointestinal stroma tumor (HP:0100723)1.81915913
110Skin ulcer (HP:0200042)1.80301849
111Amaurosis fugax (HP:0100576)1.79218378
112Hypochromic anemia (HP:0001931)1.79017983
113Abnormality of the endocardium (HP:0004306)1.78289239
114Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.77921456
115Periodontitis (HP:0000704)1.77709358
116Keratoconjunctivitis (HP:0001096)1.76850932
117Gingival bleeding (HP:0000225)1.75068959
118Increased mean platelet volume (HP:0011877)1.71955351
119Arthralgia (HP:0002829)1.67991064
120Increased density of long bones (HP:0006392)1.66415322
121Persistence of primary teeth (HP:0006335)1.65894314
122Prolonged bleeding time (HP:0003010)1.63517664
123Abnormality of the thymus (HP:0000777)1.61384971
124Acute hepatic failure (HP:0006554)1.60503418
125Microcytic anemia (HP:0001935)1.59835335
126Cellular immunodeficiency (HP:0005374)1.57545418

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK6.94517872
2MAP4K15.25898926
3ZAP703.47023843
4FGFR43.32420531
5JAK33.04020108
6IKBKE3.01363589
7ITK2.93656728
8RIPK42.72790856
9TYK22.45236421
10STK102.39814438
11MAP3K122.38750020
12NLK2.29455883
13MAP3K102.28944067
14GRK62.27315983
15MST42.26114883
16FGFR32.10946742
17NME22.10172154
18LCK2.01965161
19TAOK31.99915598
20JAK11.98388017
21MAP3K141.85054193
22TBK11.62135385
23CSK1.57266862
24SYK1.55268286
25PRKCH1.55117211
26EEF2K1.53594269
27KDR1.49945048
28MAP3K111.48716461
29CAMKK11.48139885
30CAMKK21.46260942
31MAP2K31.45814668
32TEC1.43516887
33HCK1.42349688
34PKN21.36151417
35LRRK21.33241556
36ERN11.30251749
37TAOK21.25446296
38CLK11.17589055
39IKBKB1.14966629
40BTK1.14130214
41PRKCQ1.12700572
42CDK121.11611965
43MAP3K31.04691979
44JAK20.99278159
45KIT0.97069386
46BLK0.96028628
47PRPF4B0.92553090
48IRAK40.88635806
49MAP3K130.85155155
50MAP3K10.85134880
51TESK20.84643809
52FES0.84438839
53TNK20.83680681
54CHUK0.83357239
55SMG10.81385428
56PIM10.80391330
57MAP3K70.79584571
58PDGFRB0.78171759
59TRIB30.78029773
60MAP3K50.74407937
61CDK190.72898984
62PIK3CG0.71771036
63RPS6KA40.68962647
64EPHB10.67511516
65TYRO30.67491961
66LYN0.66646684
67ALK0.66529481
68MAPK110.64903975
69CDK40.63404666
70PDK10.61130553
71MARK30.60370891
72HIPK20.59246234
73FYN0.56919320
74INSR0.55949323
75SIK20.55610347
76ADRBK10.54818560
77EPHA30.54730535
78DYRK1B0.52775701
79PDPK10.51940387
80CDK60.51042941
81MAPKAPK30.49408104
82MARK20.48588354
83CSF1R0.48551253
84MAPK70.47882321
85RET0.47250521
86STK40.46754561
87RPS6KB20.46208333
88FGR0.44125653
89MELK0.43665999
90FGFR10.43201110
91YES10.42098147
92STK380.41981213
93PASK0.39648346
94MAPK40.39305041
95SIK10.39204751
96CDC70.38984102
97IRAK10.36527389
98PRKD20.36242950
99STK110.35193108
100PDK30.34703126
101PDK40.34703126
102IGF1R0.33631081
103TGFBR10.33082018
104GRK70.32234949
105TAOK10.31711539
106TTN0.31007802
107KSR20.29755700
108MAP2K60.29749730
109MAPK30.29056192
110NUAK10.28794892
111NEK60.28370866
112DMPK0.27387880
113FGFR20.25949111
114EGFR0.25887663
115RPS6KA50.25735561
116STK240.25696869
117DAPK10.24551255
118PTK60.24442903
119UHMK10.24036382
120PRKCD0.23809311
121NTRK20.23648918
122MAP3K80.23508761
123BRD40.21078147
124MAPK120.20613768
125TGFBR20.20593161
126ABL10.19719767
127RAF10.19357805
128SGK30.17606567
129RPS6KA60.16494659
130ACVR1B0.15655021
131MAPKAPK20.15540282
132MAPK90.15525203
133SIK30.15440801

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053406.62995188
2T cell receptor signaling pathway_Homo sapiens_hsa046604.65142010
3Intestinal immune network for IgA production_Homo sapiens_hsa046723.66270318
4Inflammatory bowel disease (IBD)_Homo sapiens_hsa053213.01382133
5Measles_Homo sapiens_hsa051622.97415963
6Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.87595482
7Allograft rejection_Homo sapiens_hsa053302.78441215
8NF-kappa B signaling pathway_Homo sapiens_hsa040642.65477122
9Autoimmune thyroid disease_Homo sapiens_hsa053202.54852568
10Hematopoietic cell lineage_Homo sapiens_hsa046402.07609666
11Antigen processing and presentation_Homo sapiens_hsa046122.01061512
12Ribosome_Homo sapiens_hsa030101.94237627
13Viral myocarditis_Homo sapiens_hsa054161.90586671
14Graft-versus-host disease_Homo sapiens_hsa053321.87940656
15Leishmaniasis_Homo sapiens_hsa051401.80026244
16Osteoclast differentiation_Homo sapiens_hsa043801.76715639
17Jak-STAT signaling pathway_Homo sapiens_hsa046301.59253114
18RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.51328235
19Herpes simplex infection_Homo sapiens_hsa051681.49498260
20Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.47783999
21Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.41333569
22Leukocyte transendothelial migration_Homo sapiens_hsa046701.39714267
23B cell receptor signaling pathway_Homo sapiens_hsa046621.35937035
24Chemokine signaling pathway_Homo sapiens_hsa040621.35028033
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.34225286
26Type I diabetes mellitus_Homo sapiens_hsa049401.30430022
27Asthma_Homo sapiens_hsa053101.28022937
28Acute myeloid leukemia_Homo sapiens_hsa052211.24843092
29Shigellosis_Homo sapiens_hsa051311.24245229
30Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.23404285
31HTLV-I infection_Homo sapiens_hsa051661.20002688
32Hepatitis B_Homo sapiens_hsa051611.19256591
33Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.18826193
34Toxoplasmosis_Homo sapiens_hsa051451.18330048
35African trypanosomiasis_Homo sapiens_hsa051431.11066895
36Non-homologous end-joining_Homo sapiens_hsa034501.09343778
37NOD-like receptor signaling pathway_Homo sapiens_hsa046211.03277997
38Colorectal cancer_Homo sapiens_hsa052101.01069066
39Influenza A_Homo sapiens_hsa051640.98546515
40Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.96659715
41Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.91654743
42Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.90418949
43Chronic myeloid leukemia_Homo sapiens_hsa052200.90342511
44Apoptosis_Homo sapiens_hsa042100.86824420
45Spliceosome_Homo sapiens_hsa030400.85802774
46Viral carcinogenesis_Homo sapiens_hsa052030.85800749
47TNF signaling pathway_Homo sapiens_hsa046680.85437937
48Pancreatic cancer_Homo sapiens_hsa052120.84379441
49Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.83836228
50Platelet activation_Homo sapiens_hsa046110.82385105
51Prolactin signaling pathway_Homo sapiens_hsa049170.81730017
52Epstein-Barr virus infection_Homo sapiens_hsa051690.79974455
53SNARE interactions in vesicular transport_Homo sapiens_hsa041300.79413435
54Caffeine metabolism_Homo sapiens_hsa002320.78691026
55Phototransduction_Homo sapiens_hsa047440.75877647
56Staphylococcus aureus infection_Homo sapiens_hsa051500.75209603
57Choline metabolism in cancer_Homo sapiens_hsa052310.74410349
58Toll-like receptor signaling pathway_Homo sapiens_hsa046200.69047025
59Legionellosis_Homo sapiens_hsa051340.68671542
60Notch signaling pathway_Homo sapiens_hsa043300.67849665
61Thyroid cancer_Homo sapiens_hsa052160.67800144
62AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.66844737
63Hepatitis C_Homo sapiens_hsa051600.64595898
64Salmonella infection_Homo sapiens_hsa051320.64020830
65Adipocytokine signaling pathway_Homo sapiens_hsa049200.58859150
66Tuberculosis_Homo sapiens_hsa051520.58377294
67Phagosome_Homo sapiens_hsa041450.57858713
68Circadian rhythm_Homo sapiens_hsa047100.55155402
69Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.54583167
70p53 signaling pathway_Homo sapiens_hsa041150.52671249
71VEGF signaling pathway_Homo sapiens_hsa043700.51204745
72Neurotrophin signaling pathway_Homo sapiens_hsa047220.49632236
73Phosphatidylinositol signaling system_Homo sapiens_hsa040700.48050089
74Phospholipase D signaling pathway_Homo sapiens_hsa040720.47234355
75Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.46969764
76Regulation of autophagy_Homo sapiens_hsa041400.46925491
77mRNA surveillance pathway_Homo sapiens_hsa030150.45991072
78Non-small cell lung cancer_Homo sapiens_hsa052230.45478075
79Pertussis_Homo sapiens_hsa051330.45113570
80mTOR signaling pathway_Homo sapiens_hsa041500.44811951
81Regulation of actin cytoskeleton_Homo sapiens_hsa048100.44588931
82Transcriptional misregulation in cancer_Homo sapiens_hsa052020.44001564
83Carbohydrate digestion and absorption_Homo sapiens_hsa049730.41378910
84Glycerophospholipid metabolism_Homo sapiens_hsa005640.40787109
85Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.40651036
86ErbB signaling pathway_Homo sapiens_hsa040120.40639250
87Ras signaling pathway_Homo sapiens_hsa040140.38530799
88Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.38147084
89Small cell lung cancer_Homo sapiens_hsa052220.37958925
90DNA replication_Homo sapiens_hsa030300.37923154
91Malaria_Homo sapiens_hsa051440.37701535
92Rap1 signaling pathway_Homo sapiens_hsa040150.36425589
93Adherens junction_Homo sapiens_hsa045200.35871455
94Prostate cancer_Homo sapiens_hsa052150.35627572
95Endometrial cancer_Homo sapiens_hsa052130.34540127
96Dorso-ventral axis formation_Homo sapiens_hsa043200.33688644
97Endocytosis_Homo sapiens_hsa041440.33645216
98Thyroid hormone signaling pathway_Homo sapiens_hsa049190.33485065
99RNA degradation_Homo sapiens_hsa030180.33163620
100Rheumatoid arthritis_Homo sapiens_hsa053230.32653900
101Type II diabetes mellitus_Homo sapiens_hsa049300.32564504
102MAPK signaling pathway_Homo sapiens_hsa040100.32200053
103Base excision repair_Homo sapiens_hsa034100.31967276
104FoxO signaling pathway_Homo sapiens_hsa040680.31731079
105Mismatch repair_Homo sapiens_hsa034300.31272822
106Long-term potentiation_Homo sapiens_hsa047200.31259160
107Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.31090580
108MicroRNAs in cancer_Homo sapiens_hsa052060.29475007
109Other glycan degradation_Homo sapiens_hsa005110.29201716
110Lysine degradation_Homo sapiens_hsa003100.27645835
111Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.26518928
112HIF-1 signaling pathway_Homo sapiens_hsa040660.25962264
113GnRH signaling pathway_Homo sapiens_hsa049120.25761091
114Proteasome_Homo sapiens_hsa030500.24181946
115Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.24059578
116Cell cycle_Homo sapiens_hsa041100.23943111
117Renal cell carcinoma_Homo sapiens_hsa052110.23637618
118Pentose phosphate pathway_Homo sapiens_hsa000300.23469286
119Insulin resistance_Homo sapiens_hsa049310.22395248
120RNA transport_Homo sapiens_hsa030130.21034749
121Pathways in cancer_Homo sapiens_hsa052000.19977569
122Inositol phosphate metabolism_Homo sapiens_hsa005620.19120278
123Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.19003540
124Sphingolipid signaling pathway_Homo sapiens_hsa040710.18752724

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