

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | cytidine metabolic process (GO:0046087) | 9.60288583 |
| 2 | cytidine catabolic process (GO:0006216) | 9.60288583 |
| 3 | cytidine deamination (GO:0009972) | 9.60288583 |
| 4 | negative T cell selection (GO:0043383) | 9.08242943 |
| 5 | pyrimidine ribonucleoside catabolic process (GO:0046133) | 8.61024082 |
| 6 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 8.51526747 |
| 7 | negative thymic T cell selection (GO:0045060) | 8.34620789 |
| 8 | DNA deamination (GO:0045006) | 8.12248460 |
| 9 | positive T cell selection (GO:0043368) | 7.88552893 |
| 10 | positive regulation of gamma-delta T cell activation (GO:0046645) | 7.73326540 |
| 11 | T cell selection (GO:0045058) | 7.31274060 |
| 12 | positive thymic T cell selection (GO:0045059) | 7.27436143 |
| 13 | positive regulation of interleukin-2 biosynthetic process (GO:0045086) | 7.22046178 |
| 14 | thymic T cell selection (GO:0045061) | 7.21332757 |
| 15 | regulation of gamma-delta T cell differentiation (GO:0045586) | 6.93319537 |
| 16 | regulation of T cell tolerance induction (GO:0002664) | 6.59513908 |
| 17 | negative regulation of cell killing (GO:0031342) | 6.42338035 |
| 18 | negative regulation of leukocyte mediated cytotoxicity (GO:0001911) | 6.42338035 |
| 19 | positive regulation of antigen receptor-mediated signaling pathway (GO:0050857) | 6.36199199 |
| 20 | regulation of gamma-delta T cell activation (GO:0046643) | 6.19132243 |
| 21 | antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885) | 5.97687623 |
| 22 | antigen processing and presentation of endogenous peptide antigen (GO:0002483) | 5.97687623 |
| 23 | response to interleukin-15 (GO:0070672) | 5.86605524 |
| 24 | T cell receptor signaling pathway (GO:0050852) | 5.81670497 |
| 25 | regulation of isotype switching to IgG isotypes (GO:0048302) | 5.73831209 |
| 26 | positive regulation of tolerance induction (GO:0002645) | 5.45793391 |
| 27 | V(D)J recombination (GO:0033151) | 5.45293833 |
| 28 | interferon-gamma production (GO:0032609) | 5.44580764 |
| 29 | cellular response to interleukin-15 (GO:0071350) | 5.43521605 |
| 30 | T cell costimulation (GO:0031295) | 5.34229399 |
| 31 | negative regulation of B cell proliferation (GO:0030889) | 5.28051717 |
| 32 | lymphocyte costimulation (GO:0031294) | 5.27809646 |
| 33 | regulation of interleukin-2 biosynthetic process (GO:0045076) | 5.22835928 |
| 34 | leukocyte aggregation (GO:0070486) | 5.11972567 |
| 35 | antigen processing and presentation of endogenous antigen (GO:0019883) | 4.96625351 |
| 36 | tolerance induction (GO:0002507) | 4.94392147 |
| 37 | positive regulation of B cell differentiation (GO:0045579) | 4.88303711 |
| 38 | regulation of tolerance induction (GO:0002643) | 4.71574224 |
| 39 | antigen receptor-mediated signaling pathway (GO:0050851) | 4.69974551 |
| 40 | positive regulation of interleukin-2 production (GO:0032743) | 4.68626939 |
| 41 | regulation of regulatory T cell differentiation (GO:0045589) | 4.51513609 |
| 42 | regulation of alpha-beta T cell proliferation (GO:0046640) | 4.49899872 |
| 43 | activated T cell proliferation (GO:0050798) | 4.45882649 |
| 44 | regulation of T cell receptor signaling pathway (GO:0050856) | 4.41418519 |
| 45 | negative regulation of B cell activation (GO:0050869) | 4.36664561 |
| 46 | negative regulation of viral genome replication (GO:0045071) | 4.32351848 |
| 47 | positive regulation of granulocyte differentiation (GO:0030854) | 4.31779330 |
| 48 | T cell migration (GO:0072678) | 4.25387007 |
| 49 | positive regulation of alpha-beta T cell proliferation (GO:0046641) | 4.21620479 |
| 50 | negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665) | 4.19266212 |
| 51 | alpha-beta T cell differentiation (GO:0046632) | 4.19220543 |
| 52 | pyrimidine nucleoside catabolic process (GO:0046135) | 4.18425745 |
| 53 | regulation of antigen receptor-mediated signaling pathway (GO:0050854) | 4.16946549 |
| 54 | alpha-beta T cell activation (GO:0046631) | 4.11010580 |
| 55 | antigen processing and presentation via MHC class Ib (GO:0002475) | 4.04492226 |
| 56 | positive regulation of interleukin-8 secretion (GO:2000484) | 3.98303948 |
| 57 | T cell differentiation (GO:0030217) | 3.96295742 |
| 58 | chemokine-mediated signaling pathway (GO:0070098) | 3.90038796 |
| 59 | regulation of interleukin-12 biosynthetic process (GO:0045075) | 3.88103774 |
| 60 | B cell receptor signaling pathway (GO:0050853) | 3.85779903 |
| 61 | positive regulation of calcium-mediated signaling (GO:0050850) | 3.84382519 |
| 62 | mast cell activation (GO:0045576) | 3.83384802 |
| 63 | positive regulation of T cell mediated cytotoxicity (GO:0001916) | 3.79757918 |
| 64 | regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923) | 3.72970251 |
| 65 | regulation of T cell mediated cytotoxicity (GO:0001914) | 3.69382937 |
| 66 | regulation of interleukin-4 production (GO:0032673) | 3.69140052 |
| 67 | negative regulation of T cell mediated immunity (GO:0002710) | 3.67571627 |
| 68 | regulation of B cell receptor signaling pathway (GO:0050855) | 3.67073498 |
| 69 | cellular response to interleukin-4 (GO:0071353) | 3.62984296 |
| 70 | negative regulation of T cell receptor signaling pathway (GO:0050860) | 3.55081101 |
| 71 | regulation of isotype switching (GO:0045191) | 3.53521746 |
| 72 | positive regulation of isotype switching (GO:0045830) | 3.50399383 |
| 73 | positive regulation of defense response to virus by host (GO:0002230) | 3.49417388 |
| 74 | T cell activation (GO:0042110) | 3.49038123 |
| 75 | regulation of interleukin-2 production (GO:0032663) | 3.47558191 |
| 76 | regulation of defense response to virus by virus (GO:0050690) | 3.47064872 |
| 77 | regulation of viral genome replication (GO:0045069) | 3.41602241 |
| 78 | positive regulation of interleukin-4 production (GO:0032753) | 3.40570059 |
| 79 | Arp2/3 complex-mediated actin nucleation (GO:0034314) | 3.35482043 |
| 80 | cellular response to type I interferon (GO:0071357) | 3.34788841 |
| 81 | type I interferon signaling pathway (GO:0060337) | 3.34788841 |
| 82 | negative regulation of T cell apoptotic process (GO:0070233) | 3.33551048 |
| 83 | response to interleukin-4 (GO:0070670) | 3.32071043 |
| 84 | T cell homeostasis (GO:0043029) | 3.30522641 |
| 85 | response to type I interferon (GO:0034340) | 3.30334570 |
| 86 | response to interferon-beta (GO:0035456) | 3.28750476 |
| 87 | immune response-activating cell surface receptor signaling pathway (GO:0002429) | 3.21478965 |
| 88 | negative regulation of antigen receptor-mediated signaling pathway (GO:0050858) | 3.19848392 |
| 89 | signal complex assembly (GO:0007172) | 3.19273205 |
| 90 | mast cell activation involved in immune response (GO:0002279) | 3.18750915 |
| 91 | mast cell degranulation (GO:0043303) | 3.18750915 |
| 92 | regulation of response to interferon-gamma (GO:0060330) | 3.17024279 |
| 93 | regulation of lymphocyte chemotaxis (GO:1901623) | 3.16788382 |
| 94 | positive regulation of T cell activation (GO:0050870) | 3.14926345 |
| 95 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G | 3.14284895 |
| 96 | positive regulation of humoral immune response (GO:0002922) | 3.12657083 |
| 97 | regulation of interferon-gamma-mediated signaling pathway (GO:0060334) | 3.12351552 |
| 98 | positive regulation of leukocyte mediated cytotoxicity (GO:0001912) | 3.11167383 |
| 99 | viral transcription (GO:0019083) | 3.09818441 |
| 100 | cellular response to interferon-beta (GO:0035458) | 3.09541548 |
| 101 | negative regulation of thymocyte apoptotic process (GO:0070244) | 3.09509231 |
| 102 | positive regulation of T cell mediated immunity (GO:0002711) | 3.08089257 |
| 103 | CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294) | 3.05801964 |
| 104 | T-helper cell differentiation (GO:0042093) | 3.05801964 |
| 105 | dendritic cell chemotaxis (GO:0002407) | 3.03881193 |
| 106 | regulation of immunoglobulin production (GO:0002637) | 3.01713237 |
| 107 | regulation of natural killer cell mediated immunity (GO:0002715) | 3.01458730 |
| 108 | regulation of natural killer cell mediated cytotoxicity (GO:0042269) | 3.01458730 |
| 109 | regulation of leukocyte mediated cytotoxicity (GO:0001910) | 3.00402882 |
| 110 | regulation of immunoglobulin mediated immune response (GO:0002889) | 2.99829631 |
| 111 | positive regulation of natural killer cell mediated immunity (GO:0002717) | 2.99550369 |
| 112 | positive regulation of natural killer cell mediated cytotoxicity (GO:0045954) | 2.99550369 |
| 113 | negative regulation of viral process (GO:0048525) | 2.99032449 |
| 114 | JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397) | 2.98862126 |
| 115 | positive regulation of lymphocyte migration (GO:2000403) | 2.98294831 |
| 116 | negative regulation of lymphocyte mediated immunity (GO:0002707) | 2.97692279 |
| 117 | regulation of B cell differentiation (GO:0045577) | 2.95837245 |
| 118 | translational termination (GO:0006415) | 2.95559615 |
| 119 | T cell proliferation (GO:0042098) | 2.95488768 |
| 120 | negative regulation by host of viral transcription (GO:0043922) | 2.94205421 |
| 121 | regulation of interleukin-13 production (GO:0032656) | 2.93905794 |
| 122 | regulation of chronic inflammatory response (GO:0002676) | 2.93876598 |
| 123 | ribosomal small subunit assembly (GO:0000028) | 2.93483236 |
| 124 | somatic cell DNA recombination (GO:0016444) | 2.92884902 |
| 125 | somatic diversification of immune receptors via germline recombination within a single locus (GO:000 | 2.92884902 |
| 126 | regulation of cell killing (GO:0031341) | 2.92549954 |
| 127 | positive regulation of type I interferon-mediated signaling pathway (GO:0060340) | 2.91375672 |
| 128 | positive regulation of T cell differentiation (GO:0045582) | 2.91369136 |
| 129 | regulation of B cell proliferation (GO:0030888) | 2.90630797 |
| 130 | positive regulation of DNA recombination (GO:0045911) | 2.89517810 |
| 131 | negative regulation of erythrocyte differentiation (GO:0045647) | 2.89440899 |
| 132 | radial glial cell differentiation (GO:0060019) | 2.88911589 |
| 133 | natural killer cell differentiation (GO:0001779) | 2.88890310 |
| 134 | positive regulation of B cell mediated immunity (GO:0002714) | 2.88502597 |
| 135 | positive regulation of immunoglobulin mediated immune response (GO:0002891) | 2.88502597 |
| 136 | regulation of B cell mediated immunity (GO:0002712) | 2.88130813 |
| 137 | mucosal-associated lymphoid tissue development (GO:0048537) | 2.87998863 |
| 138 | Peyers patch development (GO:0048541) | 2.87998863 |
| 139 | positive regulation of macrophage differentiation (GO:0045651) | 2.87742424 |
| 140 | leukocyte cell-cell adhesion (GO:0007159) | 2.87363334 |
| 141 | regulation of interleukin-8 secretion (GO:2000482) | 2.85509438 |
| 142 | RNA destabilization (GO:0050779) | 2.84526943 |
| 143 | regulation of B cell activation (GO:0050864) | 2.84184333 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 8.23463606 |
| 2 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 6.19716234 |
| 3 | E2F7_22180533_ChIP-Seq_HELA_Human | 5.96457695 |
| 4 | MYC_22102868_ChIP-Seq_BL_Human | 4.14813340 |
| 5 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 3.70023412 |
| 6 | RUNX_20019798_ChIP-Seq_JUKART_Human | 3.63893874 |
| 7 | STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 3.60530719 |
| 8 | FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse | 3.40551199 |
| 9 | MYB_26560356_Chip-Seq_TH2_Human | 3.30193567 |
| 10 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 3.09261929 |
| 11 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 3.00960025 |
| 12 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 3.00018795 |
| 13 | MAF_26560356_Chip-Seq_TH1_Human | 2.93767487 |
| 14 | UTX_26944678_Chip-Seq_JUKART_Human | 2.91242631 |
| 15 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 2.81220716 |
| 16 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 2.75660616 |
| 17 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 2.71280335 |
| 18 | MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 2.64201341 |
| 19 | MYB_26560356_Chip-Seq_TH1_Human | 2.58412411 |
| 20 | CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human | 2.44376521 |
| 21 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 2.41537797 |
| 22 | VDR_21846776_ChIP-Seq_THP-1_Human | 2.39898242 |
| 23 | KDM2B_26808549_Chip-Seq_HPB-ALL_Human | 2.33043403 |
| 24 | GATA3_27048872_Chip-Seq_THYMUS_Human | 2.14172187 |
| 25 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 2.12904909 |
| 26 | MAF_26560356_Chip-Seq_TH2_Human | 2.11688531 |
| 27 | TCF7_22412390_ChIP-Seq_EML_Mouse | 2.07318739 |
| 28 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 2.00022635 |
| 29 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.94830740 |
| 30 | KDM2B_26808549_Chip-Seq_DND41_Human | 1.93141782 |
| 31 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 1.90392534 |
| 32 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 1.89245191 |
| 33 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.87224260 |
| 34 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 1.79863374 |
| 35 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.74653087 |
| 36 | RUNX1_22412390_ChIP-Seq_EML_Mouse | 1.71711294 |
| 37 | VDR_24763502_ChIP-Seq_THP-1_Human | 1.70800170 |
| 38 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 1.69687719 |
| 39 | SCL_19346495_ChIP-Seq_HPC-7_Human | 1.62043422 |
| 40 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.61033821 |
| 41 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.59886307 |
| 42 | E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 1.58244894 |
| 43 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.55887394 |
| 44 | RUNX1_17652178_ChIP-ChIP_JURKAT_Human | 1.55380787 |
| 45 | GATA1_22025678_ChIP-Seq_K562_Human | 1.51011087 |
| 46 | SPI1_23547873_ChIP-Seq_NB4_Human | 1.47355814 |
| 47 | NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse | 1.45840902 |
| 48 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.40073909 |
| 49 | SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse | 1.38854637 |
| 50 | KDM2B_26808549_Chip-Seq_JURKAT_Human | 1.34918496 |
| 51 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 1.34748026 |
| 52 | BRD4_27068464_Chip-Seq_AML-cells_Mouse | 1.33193806 |
| 53 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.32681542 |
| 54 | SPI1_23127762_ChIP-Seq_K562_Human | 1.29729350 |
| 55 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 1.29226905 |
| 56 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 1.28134368 |
| 57 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 1.24908496 |
| 58 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.19929475 |
| 59 | MEIS1_20887958_ChIP-Seq_HPC-7_Mouse | 1.19019478 |
| 60 | VDR_24787735_ChIP-Seq_THP-1_Human | 1.16467234 |
| 61 | IRF8_27001747_Chip-Seq_BMDM_Mouse | 1.16113959 |
| 62 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.13013815 |
| 63 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.12284738 |
| 64 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 1.10400962 |
| 65 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.09201778 |
| 66 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.08967361 |
| 67 | GATA3_26560356_Chip-Seq_TH2_Human | 1.08080391 |
| 68 | GATA2_22383799_ChIP-Seq_G1ME_Mouse | 1.08067218 |
| 69 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.07484726 |
| 70 | VDR_23849224_ChIP-Seq_CD4+_Human | 1.05516156 |
| 71 | TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse | 1.05410431 |
| 72 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 1.04296629 |
| 73 | PU_27001747_Chip-Seq_BMDM_Mouse | 1.03121367 |
| 74 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 1.02228283 |
| 75 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 1.00201711 |
| 76 | GATA2_20887958_ChIP-Seq_HPC-7_Mouse | 0.98543247 |
| 77 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 0.98458899 |
| 78 | XRN2_22483619_ChIP-Seq_HELA_Human | 0.93221583 |
| 79 | CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse | 0.92976794 |
| 80 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 0.92720032 |
| 81 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 0.92561377 |
| 82 | GATA3_26560356_Chip-Seq_TH1_Human | 0.91080509 |
| 83 | ELK1_19687146_ChIP-ChIP_HELA_Human | 0.90416823 |
| 84 | PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse | 0.89814637 |
| 85 | PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse | 0.89514708 |
| 86 | VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human | 0.88390437 |
| 87 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 0.85690366 |
| 88 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 0.85468442 |
| 89 | KDM5A_27292631_Chip-Seq_BREAST_Human | 0.85461014 |
| 90 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 0.84194214 |
| 91 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 0.82496667 |
| 92 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 0.81990759 |
| 93 | PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 0.81456066 |
| 94 | RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.80877355 |
| 95 | NCOR1_26117541_ChIP-Seq_K562_Human | 0.79115633 |
| 96 | PBX1_22567123_ChIP-ChIP_OVCAR3_Human | 0.77678815 |
| 97 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 0.76798773 |
| 98 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 0.76442373 |
| 99 | PRDM14_20953172_ChIP-Seq_ESCs_Human | 0.74533433 |
| 100 | GATA1_22383799_ChIP-Seq_G1ME_Mouse | 0.73718051 |
| 101 | CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 0.73320988 |
| 102 | BCL6_27268052_Chip-Seq_Bcells_Human | 0.71749193 |
| 103 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 0.71665439 |
| 104 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.70533714 |
| 105 | TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.68753066 |
| 106 | CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 0.67661084 |
| 107 | CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse | 0.67637130 |
| 108 | CEBPB_22108803_ChIP-Seq_LS180_Human | 0.66943230 |
| 109 | Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse | 0.66241039 |
| 110 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 0.65964385 |
| 111 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 0.65507243 |
| 112 | PU.1_20513432_ChIP-Seq_Bcells_Mouse | 0.65459123 |
| 113 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 0.65132521 |
| 114 | KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human | 0.64272563 |
| 115 | CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse | 0.62897579 |
| 116 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 0.62683268 |
| 117 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 0.62174773 |
| 118 | NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human | 0.60801889 |
| 119 | LMO2_20887958_ChIP-Seq_HPC-7_Mouse | 0.60732799 |
| 120 | RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.60361436 |
| 121 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 0.59975845 |
| 122 | SMRT_27268052_Chip-Seq_Bcells_Human | 0.59614709 |
| 123 | TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.59130837 |
| 124 | IRF1_19129219_ChIP-ChIP_H3396_Human | 0.58787103 |
| 125 | GATA1_19941826_ChIP-Seq_K562_Human | 0.57170332 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003763_abnormal_thymus_physiology | 6.55321322 |
| 2 | MP0005671_abnormal_response_to | 4.15705766 |
| 3 | MP0000703_abnormal_thymus_morphology | 3.33078501 |
| 4 | MP0000685_abnormal_immune_system | 3.32576302 |
| 5 | MP0009333_abnormal_splenocyte_physiolog | 3.27446164 |
| 6 | MP0002166_altered_tumor_susceptibility | 3.19028147 |
| 7 | MP0003300_gastrointestinal_ulcer | 2.96595523 |
| 8 | MP0002398_abnormal_bone_marrow | 2.91491260 |
| 9 | MP0004381_abnormal_hair_follicle | 2.84678698 |
| 10 | MP0001800_abnormal_humoral_immune | 2.81702915 |
| 11 | MP0001835_abnormal_antigen_presentation | 2.67441823 |
| 12 | MP0002006_tumorigenesis | 2.66691988 |
| 13 | MP0005000_abnormal_immune_tolerance | 2.57064034 |
| 14 | MP0002420_abnormal_adaptive_immunity | 2.56090499 |
| 15 | MP0002396_abnormal_hematopoietic_system | 2.52959065 |
| 16 | MP0001819_abnormal_immune_cell | 2.52161259 |
| 17 | MP0005387_immune_system_phenotype | 2.49313496 |
| 18 | MP0001790_abnormal_immune_system | 2.49313496 |
| 19 | MP0002723_abnormal_immune_serum | 2.48962437 |
| 20 | MP0002722_abnormal_immune_system | 2.48909767 |
| 21 | MP0002405_respiratory_system_inflammati | 2.46951351 |
| 22 | MP0000716_abnormal_immune_system | 2.41910688 |
| 23 | MP0001873_stomach_inflammation | 2.41306705 |
| 24 | MP0003866_abnormal_defecation | 2.35484885 |
| 25 | MP0000689_abnormal_spleen_morphology | 2.25285174 |
| 26 | MP0002452_abnormal_antigen_presenting | 2.20739635 |
| 27 | MP0003303_peritoneal_inflammation | 2.15971433 |
| 28 | MP0004947_skin_inflammation | 2.09819503 |
| 29 | MP0003436_decreased_susceptibility_to | 2.07614014 |
| 30 | MP0010155_abnormal_intestine_physiology | 2.07514064 |
| 31 | MP0003724_increased_susceptibility_to | 2.03217445 |
| 32 | MP0004808_abnormal_hematopoietic_stem | 2.02868775 |
| 33 | MP0002429_abnormal_blood_cell | 1.96881701 |
| 34 | MP0005025_abnormal_response_to | 1.96352269 |
| 35 | MP0009785_altered_susceptibility_to | 1.95934415 |
| 36 | MP0006082_CNS_inflammation | 1.79988084 |
| 37 | MP0002933_joint_inflammation | 1.79885235 |
| 38 | MP0003806_abnormal_nucleotide_metabolis | 1.74198758 |
| 39 | MP0005075_abnormal_melanosome_morpholog | 1.70106754 |
| 40 | MP0002163_abnormal_gland_morphology | 1.63222784 |
| 41 | MP0005310_abnormal_salivary_gland | 1.58400485 |
| 42 | MP0001853_heart_inflammation | 1.57110415 |
| 43 | MP0002877_abnormal_melanocyte_morpholog | 1.56644377 |
| 44 | MP0004510_myositis | 1.52927325 |
| 45 | MP0001845_abnormal_inflammatory_respons | 1.50882488 |
| 46 | MP0000372_irregular_coat_pigmentation | 1.47635608 |
| 47 | MP0002148_abnormal_hypersensitivity_rea | 1.43421958 |
| 48 | MP0010352_gastrointestinal_tract_polyps | 1.41773829 |
| 49 | MP0005464_abnormal_platelet_physiology | 1.41646755 |
| 50 | MP0000465_gastrointestinal_hemorrhage | 1.35343943 |
| 51 | MP0002419_abnormal_innate_immunity | 1.33184212 |
| 52 | MP0005397_hematopoietic_system_phenotyp | 1.32740696 |
| 53 | MP0001545_abnormal_hematopoietic_system | 1.32740696 |
| 54 | MP0002277_abnormal_respiratory_mucosa | 1.31584351 |
| 55 | MP0008057_abnormal_DNA_replication | 1.25351613 |
| 56 | MP0010094_abnormal_chromosome_stability | 1.21337526 |
| 57 | MP0000858_altered_metastatic_potential | 1.19684094 |
| 58 | MP0005379_endocrine/exocrine_gland_phen | 1.19612018 |
| 59 | MP0008961_abnormal_basal_metabolism | 1.16348655 |
| 60 | MP0000490_abnormal_crypts_of | 1.15918368 |
| 61 | MP0002019_abnormal_tumor_incidence | 1.10860939 |
| 62 | MP0005076_abnormal_cell_differentiation | 1.06126767 |
| 63 | MP0003077_abnormal_cell_cycle | 1.05703833 |
| 64 | MP0003786_premature_aging | 1.03591666 |
| 65 | MP0005023_abnormal_wound_healing | 1.01641423 |
| 66 | MP0003448_altered_tumor_morphology | 1.00405400 |
| 67 | MP0002009_preneoplasia | 0.99853811 |
| 68 | MP0002693_abnormal_pancreas_physiology | 0.96932231 |
| 69 | MP0006054_spinal_hemorrhage | 0.93885723 |
| 70 | MP0003693_abnormal_embryo_hatching | 0.92556742 |
| 71 | MP0004957_abnormal_blastocyst_morpholog | 0.90562962 |
| 72 | MP0001851_eye_inflammation | 0.88572332 |
| 73 | MP0009278_abnormal_bone_marrow | 0.86981542 |
| 74 | MP0009764_decreased_sensitivity_to | 0.86645105 |
| 75 | MP0008995_early_reproductive_senescence | 0.81072431 |
| 76 | MP0001533_abnormal_skeleton_physiology | 0.80476962 |
| 77 | MP0008469_abnormal_protein_level | 0.79379822 |
| 78 | MP0003045_fibrosis | 0.77575576 |
| 79 | MP0000350_abnormal_cell_proliferation | 0.73441210 |
| 80 | MP0001243_abnormal_dermal_layer | 0.72758758 |
| 81 | MP0003111_abnormal_nucleus_morphology | 0.71395275 |
| 82 | MP0002998_abnormal_bone_remodeling | 0.70543488 |
| 83 | MP0004185_abnormal_adipocyte_glucose | 0.68885267 |
| 84 | MP0001348_abnormal_lacrimal_gland | 0.68412521 |
| 85 | MP0002653_abnormal_ependyma_morphology | 0.65629440 |
| 86 | MP0000609_abnormal_liver_physiology | 0.65085281 |
| 87 | MP0005174_abnormal_tail_pigmentation | 0.62084433 |
| 88 | MP0005390_skeleton_phenotype | 0.61314707 |
| 89 | MP0001730_embryonic_growth_arrest | 0.61241928 |
| 90 | MP0008007_abnormal_cellular_replicative | 0.61173926 |
| 91 | MP0000477_abnormal_intestine_morphology | 0.60265023 |
| 92 | MP0005409_darkened_coat_color | 0.59451289 |
| 93 | MP0002822_catalepsy | 0.58422888 |
| 94 | MP0000383_abnormal_hair_follicle | 0.57918618 |
| 95 | MP0002970_abnormal_white_adipose | 0.56988853 |
| 96 | MP0009765_abnormal_xenobiotic_induced | 0.56942365 |
| 97 | MP0000313_abnormal_cell_death | 0.55578563 |
| 98 | MP0008877_abnormal_DNA_methylation | 0.55202698 |
| 99 | MP0003795_abnormal_bone_structure | 0.54803803 |
| 100 | MP0001919_abnormal_reproductive_system | 0.54578667 |
| 101 | MP0002132_abnormal_respiratory_system | 0.54562015 |
| 102 | MP0002876_abnormal_thyroid_physiology | 0.53716856 |
| 103 | MP0001663_abnormal_digestive_system | 0.53495808 |
| 104 | MP0009763_increased_sensitivity_to | 0.53159173 |
| 105 | MP0002095_abnormal_skin_pigmentation | 0.52110033 |
| 106 | MP0005381_digestive/alimentary_phenotyp | 0.51687413 |
| 107 | MP0003183_abnormal_peptide_metabolism | 0.49891904 |
| 108 | MP0003221_abnormal_cardiomyocyte_apopto | 0.49720101 |
| 109 | MP0003279_aneurysm | 0.49678057 |
| 110 | MP0000371_diluted_coat_color | 0.49121257 |
| 111 | MP0000604_amyloidosis | 0.48737590 |
| 112 | MP0001188_hyperpigmentation | 0.47852672 |
| 113 | MP0000249_abnormal_blood_vessel | 0.47524041 |
| 114 | MP0010307_abnormal_tumor_latency | 0.47384964 |
| 115 | MP0001727_abnormal_embryo_implantation | 0.46638101 |
| 116 | MP0000367_abnormal_coat/_hair | 0.45127684 |
| 117 | MP0003172_abnormal_lysosome_physiology | 0.44883634 |
| 118 | MP0008873_increased_physiological_sensi | 0.44406157 |
| 119 | MP0009643_abnormal_urine_homeostasis | 0.44157163 |
| 120 | MP0001216_abnormal_epidermal_layer | 0.44074750 |
| 121 | MP0002138_abnormal_hepatobiliary_system | 0.44019889 |
| 122 | MP0002086_abnormal_extraembryonic_tissu | 0.43511757 |
| 123 | MP0001984_abnormal_olfaction | 0.43193472 |
| 124 | MP0000377_abnormal_hair_follicle | 0.42893357 |
| 125 | MP0002136_abnormal_kidney_physiology | 0.42838305 |
| 126 | MP0003091_abnormal_cell_migration | 0.42327843 |
| 127 | MP0008770_decreased_survivor_rate | 0.42035355 |
| 128 | MP0004130_abnormal_muscle_cell | 0.38643254 |
| 129 | MP0003567_abnormal_fetal_cardiomyocyte | 0.36159974 |
| 130 | MP0006036_abnormal_mitochondrial_physio | 0.35823567 |
| 131 | MP0002083_premature_death | 0.35071067 |
| 132 | MP0006035_abnormal_mitochondrial_morpho | 0.34894196 |
| 133 | MP0000613_abnormal_salivary_gland | 0.32264815 |
| 134 | MP0001502_abnormal_circadian_rhythm | 0.32257681 |
| 135 | MP0005408_hypopigmentation | 0.32195189 |
| 136 | MP0001765_abnormal_ion_homeostasis | 0.31981007 |
| 137 | MP0005166_decreased_susceptibility_to | 0.29149865 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | T lymphocytopenia (HP:0005403) | 8.84590608 |
| 2 | Abnormality of T cell number (HP:0011839) | 8.44765440 |
| 3 | Severe combined immunodeficiency (HP:0004430) | 6.45871188 |
| 4 | Combined immunodeficiency (HP:0005387) | 6.03987393 |
| 5 | Abnormality of T cells (HP:0002843) | 5.69232238 |
| 6 | Panhypogammaglobulinemia (HP:0003139) | 5.18264279 |
| 7 | Recurrent viral infections (HP:0004429) | 5.14030633 |
| 8 | B lymphocytopenia (HP:0010976) | 4.92651397 |
| 9 | Abnormality of B cell number (HP:0010975) | 4.92651397 |
| 10 | Recurrent fungal infections (HP:0002841) | 4.77003788 |
| 11 | Elevated erythrocyte sedimentation rate (HP:0003565) | 4.74359259 |
| 12 | Eosinophilia (HP:0001880) | 4.64773063 |
| 13 | Stomatitis (HP:0010280) | 4.36449111 |
| 14 | IgG deficiency (HP:0004315) | 4.35891563 |
| 15 | Abnormality of eosinophils (HP:0001879) | 4.34681916 |
| 16 | Abnormality of the fingertips (HP:0001211) | 4.25159374 |
| 17 | Thyroiditis (HP:0100646) | 4.20276451 |
| 18 | Autoimmune hemolytic anemia (HP:0001890) | 4.10964176 |
| 19 | Recurrent bronchitis (HP:0002837) | 4.10246186 |
| 20 | Granulocytopenia (HP:0001913) | 3.91145506 |
| 21 | Abnormality of the pleura (HP:0002103) | 3.81774114 |
| 22 | Hypoplasia of the thymus (HP:0000778) | 3.73839370 |
| 23 | Abnormal delayed hypersensitivity skin test (HP:0002963) | 3.67411684 |
| 24 | Chronic otitis media (HP:0000389) | 3.65358634 |
| 25 | Leukocytosis (HP:0001974) | 3.63553118 |
| 26 | IgM deficiency (HP:0002850) | 3.62073793 |
| 27 | Nasal polyposis (HP:0100582) | 3.48042229 |
| 28 | Alveolar cell carcinoma (HP:0006519) | 3.42016791 |
| 29 | Joint swelling (HP:0001386) | 3.34009672 |
| 30 | Lymphopenia (HP:0001888) | 3.33968597 |
| 31 | Recurrent cutaneous fungal infections (HP:0011370) | 3.31376273 |
| 32 | Chronic mucocutaneous candidiasis (HP:0002728) | 3.31376273 |
| 33 | Chronic diarrhea (HP:0002028) | 3.25751549 |
| 34 | Abnormality of cells of the lymphoid lineage (HP:0012140) | 3.24925610 |
| 35 | Abnormality of the pericardium (HP:0001697) | 3.24331470 |
| 36 | Myositis (HP:0100614) | 3.20984423 |
| 37 | Pulmonary fibrosis (HP:0002206) | 3.17255468 |
| 38 | Eczematoid dermatitis (HP:0000976) | 3.17210731 |
| 39 | Abnormality of T cell physiology (HP:0011840) | 3.15266898 |
| 40 | Agammaglobulinemia (HP:0004432) | 3.14376548 |
| 41 | Abnormality of macrophages (HP:0004311) | 3.13839786 |
| 42 | Neoplasm of the tracheobronchial system (HP:0100552) | 3.07175139 |
| 43 | Pustule (HP:0200039) | 3.02761923 |
| 44 | Abnormality of male internal genitalia (HP:0000022) | 3.00593800 |
| 45 | Increased IgM level (HP:0003496) | 2.99746474 |
| 46 | Basal cell carcinoma (HP:0002671) | 2.96011408 |
| 47 | IgA deficiency (HP:0002720) | 2.93009618 |
| 48 | Glomerulopathy (HP:0100820) | 2.91796047 |
| 49 | Abnormality of the nasal mucosa (HP:0000433) | 2.89595648 |
| 50 | Aplastic anemia (HP:0001915) | 2.86994005 |
| 51 | Recurrent bacterial skin infections (HP:0005406) | 2.83624169 |
| 52 | Autoimmune thrombocytopenia (HP:0001973) | 2.81735176 |
| 53 | Polyneuropathy (HP:0001271) | 2.76810561 |
| 54 | Lymphoma (HP:0002665) | 2.60056246 |
| 55 | Recurrent abscess formation (HP:0002722) | 2.59887324 |
| 56 | Spontaneous hematomas (HP:0007420) | 2.57016527 |
| 57 | Meningitis (HP:0001287) | 2.55160515 |
| 58 | Thrombophlebitis (HP:0004418) | 2.50968229 |
| 59 | Hemoptysis (HP:0002105) | 2.48830543 |
| 60 | Retrobulbar optic neuritis (HP:0100654) | 2.46297101 |
| 61 | Optic neuritis (HP:0100653) | 2.46297101 |
| 62 | Verrucae (HP:0200043) | 2.45809579 |
| 63 | Papilloma (HP:0012740) | 2.45809579 |
| 64 | Bicuspid aortic valve (HP:0001647) | 2.45574494 |
| 65 | Abnormal platelet volume (HP:0011876) | 2.44904417 |
| 66 | Increased density of long bones (HP:0006392) | 2.43041558 |
| 67 | Anorexia (HP:0002039) | 2.41106126 |
| 68 | Restrictive lung disease (HP:0002091) | 2.35818702 |
| 69 | Thrombocytosis (HP:0001894) | 2.33827152 |
| 70 | Vasculitis (HP:0002633) | 2.32668936 |
| 71 | Pulmonary infiltrates (HP:0002113) | 2.30694742 |
| 72 | Volvulus (HP:0002580) | 2.30033432 |
| 73 | Skin rash (HP:0000988) | 2.29056635 |
| 74 | Bronchitis (HP:0012387) | 2.28157812 |
| 75 | Ureteral stenosis (HP:0000071) | 2.27971338 |
| 76 | Recurrent otitis media (HP:0000403) | 2.27483054 |
| 77 | Encephalitis (HP:0002383) | 2.26779998 |
| 78 | Papilledema (HP:0001085) | 2.23630709 |
| 79 | Gastrointestinal infarctions (HP:0005244) | 2.19635209 |
| 80 | Oral leukoplakia (HP:0002745) | 2.19252936 |
| 81 | Hypergammaglobulinemia (HP:0010702) | 2.17962431 |
| 82 | Orchitis (HP:0100796) | 2.12884085 |
| 83 | Petechiae (HP:0000967) | 2.12495272 |
| 84 | Aplasia/Hypoplasia of the thymus (HP:0010515) | 2.11969540 |
| 85 | Pulmonary embolism (HP:0002204) | 2.10506861 |
| 86 | Increased IgE level (HP:0003212) | 2.09986916 |
| 87 | Keratoconjunctivitis sicca (HP:0001097) | 2.08441718 |
| 88 | Ureteral obstruction (HP:0006000) | 2.07993086 |
| 89 | Chest pain (HP:0100749) | 2.06889746 |
| 90 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 2.06439558 |
| 91 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 2.06439558 |
| 92 | Pancreatitis (HP:0001733) | 2.06197037 |
| 93 | Cutis marmorata (HP:0000965) | 2.05653968 |
| 94 | Gastrointestinal inflammation (HP:0004386) | 2.05495847 |
| 95 | Arterial thrombosis (HP:0004420) | 2.03883569 |
| 96 | Diplopia (HP:0000651) | 2.02947954 |
| 97 | Abnormality of binocular vision (HP:0011514) | 2.02947954 |
| 98 | Increased mean platelet volume (HP:0011877) | 2.02379099 |
| 99 | Inflammation of the large intestine (HP:0002037) | 1.99540990 |
| 100 | Pigmentary retinal degeneration (HP:0001146) | 1.97809029 |
| 101 | Hypochromic anemia (HP:0001931) | 1.96519145 |
| 102 | Chronic obstructive pulmonary disease (HP:0006510) | 1.95339438 |
| 103 | Obstructive lung disease (HP:0006536) | 1.95339438 |
| 104 | Amaurosis fugax (HP:0100576) | 1.93985897 |
| 105 | Epistaxis (HP:0000421) | 1.93412117 |
| 106 | Micronodular cirrhosis (HP:0001413) | 1.90825097 |
| 107 | Mediastinal lymphadenopathy (HP:0100721) | 1.90267301 |
| 108 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 1.88234042 |
| 109 | Hypoproteinemia (HP:0003075) | 1.87275140 |
| 110 | Abnormality of cells of the erythroid lineage (HP:0012130) | 1.86945542 |
| 111 | Reticulocytopenia (HP:0001896) | 1.86582132 |
| 112 | Acute myeloid leukemia (HP:0004808) | 1.86581771 |
| 113 | Poikiloderma (HP:0001029) | 1.85219027 |
| 114 | Keratoconjunctivitis (HP:0001096) | 1.84949811 |
| 115 | Abnormality of the prostate (HP:0008775) | 1.84764977 |
| 116 | Paresthesia (HP:0003401) | 1.84510878 |
| 117 | Retinopathy (HP:0000488) | 1.83485195 |
| 118 | Abnormality of oral frenula (HP:0000190) | 1.81835742 |
| 119 | Increased intramyocellular lipid droplets (HP:0012240) | 1.80768534 |
| 120 | Facial diplegia (HP:0001349) | 1.80306643 |
| 121 | Keratitis (HP:0000491) | 1.79500614 |
| 122 | Facial edema (HP:0000282) | 1.78834572 |
| 123 | Slow saccadic eye movements (HP:0000514) | 1.77896281 |
| 124 | Porencephaly (HP:0002132) | 1.77613148 |
| 125 | Recurrent sinusitis (HP:0011108) | 1.76734002 |
| 126 | Persistence of primary teeth (HP:0006335) | 1.76314016 |
| 127 | Prolonged bleeding time (HP:0003010) | 1.75861736 |
| 128 | Abnormality of the thymus (HP:0000777) | 1.74539307 |
| 129 | Broad palm (HP:0001169) | 1.74441677 |
| 130 | Entropion (HP:0000621) | 1.73854030 |
| 131 | Chronic sinusitis (HP:0011109) | 1.71911935 |
| 132 | Gingival bleeding (HP:0000225) | 1.71255874 |
| 133 | Recurrent skin infections (HP:0001581) | 1.68915942 |
| 134 | Dislocated radial head (HP:0003083) | 1.67995710 |
| 135 | Prominent nose (HP:0000448) | 1.67486274 |
| 136 | Gangrene (HP:0100758) | 1.66032890 |
| 137 | Trigonocephaly (HP:0000243) | 1.65726477 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | TXK | 6.88301242 |
| 2 | MAP4K1 | 5.37413771 |
| 3 | ZAP70 | 3.21761808 |
| 4 | NLK | 3.21298734 |
| 5 | ITK | 3.02830985 |
| 6 | STK10 | 2.93709071 |
| 7 | FGFR4 | 2.90106313 |
| 8 | JAK3 | 2.74477406 |
| 9 | EEF2K | 2.56587035 |
| 10 | RIPK4 | 2.54596854 |
| 11 | MAP2K6 | 2.36607610 |
| 12 | GRK6 | 2.23474030 |
| 13 | TYK2 | 2.22673612 |
| 14 | FGFR3 | 2.14366432 |
| 15 | IRAK4 | 2.13601314 |
| 16 | IKBKE | 2.05733494 |
| 17 | PKN2 | 1.91798552 |
| 18 | LCK | 1.89148495 |
| 19 | TAOK3 | 1.80450718 |
| 20 | MAP3K10 | 1.73301792 |
| 21 | CAMKK2 | 1.70896248 |
| 22 | SIK3 | 1.67576859 |
| 23 | MST4 | 1.61079375 |
| 24 | JAK1 | 1.55823060 |
| 25 | SYK | 1.51011153 |
| 26 | CDK12 | 1.48324328 |
| 27 | LRRK2 | 1.42694459 |
| 28 | CSK | 1.39113772 |
| 29 | PRKCH | 1.35722175 |
| 30 | PRKCQ | 1.34116412 |
| 31 | HCK | 1.32920571 |
| 32 | TEC | 1.30204198 |
| 33 | TRIB3 | 1.27000246 |
| 34 | SCYL2 | 1.26750508 |
| 35 | NME2 | 1.24692754 |
| 36 | MAP3K7 | 1.24548934 |
| 37 | CDC7 | 1.23063809 |
| 38 | KIT | 1.19224433 |
| 39 | GRK7 | 1.18213943 |
| 40 | MAP3K14 | 1.17646437 |
| 41 | PDGFRB | 1.10195638 |
| 42 | BTK | 1.06460895 |
| 43 | CLK1 | 1.05993169 |
| 44 | JAK2 | 0.96584813 |
| 45 | TBK1 | 0.94760384 |
| 46 | ADRBK2 | 0.93421260 |
| 47 | FGFR2 | 0.90614000 |
| 48 | CAMKK1 | 0.85318187 |
| 49 | STK39 | 0.84608601 |
| 50 | TYRO3 | 0.82665640 |
| 51 | RPS6KA4 | 0.82338890 |
| 52 | FES | 0.82240626 |
| 53 | PIM1 | 0.81568286 |
| 54 | RPS6KB2 | 0.81494101 |
| 55 | MAP3K9 | 0.78374749 |
| 56 | MAP3K13 | 0.78138028 |
| 57 | MARK3 | 0.76571572 |
| 58 | CDK4 | 0.75992240 |
| 59 | STK4 | 0.74527885 |
| 60 | ALK | 0.73869168 |
| 61 | TESK2 | 0.71107382 |
| 62 | SRPK1 | 0.68795341 |
| 63 | WNK4 | 0.66232967 |
| 64 | MAPK7 | 0.66226464 |
| 65 | IKBKB | 0.65798601 |
| 66 | MELK | 0.65349723 |
| 67 | MARK2 | 0.64935006 |
| 68 | SIK2 | 0.64871698 |
| 69 | HIPK2 | 0.64063752 |
| 70 | CDK6 | 0.63439245 |
| 71 | IRAK1 | 0.63154284 |
| 72 | FGFR1 | 0.62596644 |
| 73 | PASK | 0.62322796 |
| 74 | CHUK | 0.61987515 |
| 75 | TNK2 | 0.61463666 |
| 76 | EPHB1 | 0.60578521 |
| 77 | TAOK1 | 0.59844351 |
| 78 | PTK6 | 0.59254574 |
| 79 | LYN | 0.58951221 |
| 80 | KDR | 0.56272621 |
| 81 | FGR | 0.56207256 |
| 82 | PDK1 | 0.56020983 |
| 83 | BMPR2 | 0.54561062 |
| 84 | MAP3K3 | 0.54494752 |
| 85 | MATK | 0.54432809 |
| 86 | BRD4 | 0.54408729 |
| 87 | NTRK2 | 0.54345880 |
| 88 | MAP3K8 | 0.54260489 |
| 89 | FYN | 0.52946857 |
| 90 | OXSR1 | 0.51695812 |
| 91 | CDK8 | 0.50715654 |
| 92 | INSR | 0.49872243 |
| 93 | NEK2 | 0.46901368 |
| 94 | PDGFRA | 0.45589181 |
| 95 | TTN | 0.44146758 |
| 96 | CDK9 | 0.43810476 |
| 97 | STK11 | 0.42932309 |
| 98 | CSF1R | 0.41717232 |
| 99 | FLT3 | 0.41218539 |
| 100 | BMPR1B | 0.41158131 |
| 101 | MAPK11 | 0.41050347 |
| 102 | MAPK4 | 0.41027533 |
| 103 | BLK | 0.38196862 |
| 104 | RAF1 | 0.38099197 |
| 105 | MAP3K1 | 0.38077113 |
| 106 | TGFBR2 | 0.37222340 |
| 107 | WNK1 | 0.36571677 |
| 108 | SGK3 | 0.36101463 |
| 109 | CHEK1 | 0.36082822 |
| 110 | NEK6 | 0.35059451 |
| 111 | ATR | 0.33200666 |
| 112 | TSSK6 | 0.32931120 |
| 113 | MAPK12 | 0.32675310 |
| 114 | DYRK1A | 0.31532630 |
| 115 | TGFBR1 | 0.31403452 |
| 116 | PIK3CG | 0.28970813 |
| 117 | EGFR | 0.28563297 |
| 118 | MAP2K3 | 0.28478380 |
| 119 | ATM | 0.27837404 |
| 120 | IGF1R | 0.27488711 |
| 121 | MAPK3 | 0.27184033 |
| 122 | EPHA3 | 0.26651036 |
| 123 | MAPK9 | 0.23589180 |
| 124 | CAMK4 | 0.23178706 |
| 125 | PRPF4B | 0.22877552 |
| 126 | CDK2 | 0.21582514 |
| 127 | PINK1 | 0.21098395 |
| 128 | RET | 0.20355102 |
| 129 | RPS6KA5 | 0.20340184 |
| 130 | KSR2 | 0.20232625 |
| 131 | ERN1 | 0.20100831 |
| 132 | MAPKAPK2 | 0.19586924 |
| 133 | RPS6KA6 | 0.19195889 |
| 134 | EIF2AK3 | 0.17529769 |
| 135 | NUAK1 | 0.17339274 |
| 136 | FRK | 0.16239530 |
| 137 | CCNB1 | 0.15441732 |
| 138 | MAP3K11 | 0.13281830 |
| 139 | PRKCD | 0.13110640 |
| 140 | PRKCZ | 0.11408832 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Primary immunodeficiency_Homo sapiens_hsa05340 | 6.15737020 |
| 2 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 4.69146838 |
| 3 | Measles_Homo sapiens_hsa05162 | 2.86088425 |
| 4 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 2.59832442 |
| 5 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 2.59106990 |
| 6 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 2.53056572 |
| 7 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 2.31753913 |
| 8 | Allograft rejection_Homo sapiens_hsa05330 | 2.31710960 |
| 9 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 2.27396664 |
| 10 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 2.06415272 |
| 11 | Proteasome_Homo sapiens_hsa03050 | 2.04694132 |
| 12 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.88471554 |
| 13 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 1.84832891 |
| 14 | Antigen processing and presentation_Homo sapiens_hsa04612 | 1.80424221 |
| 15 | Viral myocarditis_Homo sapiens_hsa05416 | 1.79395955 |
| 16 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 1.74749653 |
| 17 | Ribosome_Homo sapiens_hsa03010 | 1.70291383 |
| 18 | Osteoclast differentiation_Homo sapiens_hsa04380 | 1.64659095 |
| 19 | Leishmaniasis_Homo sapiens_hsa05140 | 1.63809381 |
| 20 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 1.58386690 |
| 21 | Colorectal cancer_Homo sapiens_hsa05210 | 1.47491884 |
| 22 | HTLV-I infection_Homo sapiens_hsa05166 | 1.45166316 |
| 23 | Thyroid cancer_Homo sapiens_hsa05216 | 1.40179346 |
| 24 | Hepatitis B_Homo sapiens_hsa05161 | 1.39361166 |
| 25 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 1.38319788 |
| 26 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 1.37951953 |
| 27 | Herpes simplex infection_Homo sapiens_hsa05168 | 1.36499120 |
| 28 | Graft-versus-host disease_Homo sapiens_hsa05332 | 1.35002265 |
| 29 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 1.32960133 |
| 30 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 1.32652355 |
| 31 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 1.29225178 |
| 32 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 1.24730756 |
| 33 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 1.21438944 |
| 34 | Toxoplasmosis_Homo sapiens_hsa05145 | 1.19461021 |
| 35 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 1.18878291 |
| 36 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 1.17531905 |
| 37 | Spliceosome_Homo sapiens_hsa03040 | 1.10434126 |
| 38 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 1.09308190 |
| 39 | Pancreatic cancer_Homo sapiens_hsa05212 | 1.04751664 |
| 40 | Viral carcinogenesis_Homo sapiens_hsa05203 | 1.03838892 |
| 41 | Notch signaling pathway_Homo sapiens_hsa04330 | 1.02751498 |
| 42 | DNA replication_Homo sapiens_hsa03030 | 1.01298962 |
| 43 | Influenza A_Homo sapiens_hsa05164 | 0.95538514 |
| 44 | Endometrial cancer_Homo sapiens_hsa05213 | 0.94430780 |
| 45 | Asthma_Homo sapiens_hsa05310 | 0.94389794 |
| 46 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.93902433 |
| 47 | Shigellosis_Homo sapiens_hsa05131 | 0.93659118 |
| 48 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.90382936 |
| 49 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.90085833 |
| 50 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.89363730 |
| 51 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.89329391 |
| 52 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.87349794 |
| 53 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.84536768 |
| 54 | Platelet activation_Homo sapiens_hsa04611 | 0.81981703 |
| 55 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.80869631 |
| 56 | One carbon pool by folate_Homo sapiens_hsa00670 | 0.80451540 |
| 57 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.79776746 |
| 58 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.79636113 |
| 59 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.79405276 |
| 60 | Apoptosis_Homo sapiens_hsa04210 | 0.78709698 |
| 61 | Prostate cancer_Homo sapiens_hsa05215 | 0.77469565 |
| 62 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.77369709 |
| 63 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.77163676 |
| 64 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.74288864 |
| 65 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 0.71810636 |
| 66 | Hepatitis C_Homo sapiens_hsa05160 | 0.65615328 |
| 67 | TNF signaling pathway_Homo sapiens_hsa04668 | 0.64194703 |
| 68 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.63925301 |
| 69 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 0.62808798 |
| 70 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.62076380 |
| 71 | RNA transport_Homo sapiens_hsa03013 | 0.62070311 |
| 72 | Cell cycle_Homo sapiens_hsa04110 | 0.61930480 |
| 73 | Lysine degradation_Homo sapiens_hsa00310 | 0.61808846 |
| 74 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.61705090 |
| 75 | Mismatch repair_Homo sapiens_hsa03430 | 0.61143253 |
| 76 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.60700088 |
| 77 | Adherens junction_Homo sapiens_hsa04520 | 0.59881901 |
| 78 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.59505189 |
| 79 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.58987247 |
| 80 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.58794784 |
| 81 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.58280408 |
| 82 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.57780513 |
| 83 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 0.57665452 |
| 84 | RNA polymerase_Homo sapiens_hsa03020 | 0.56593694 |
| 85 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.56528396 |
| 86 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.56339319 |
| 87 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.56128077 |
| 88 | RNA degradation_Homo sapiens_hsa03018 | 0.54455823 |
| 89 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.53485840 |
| 90 | Legionellosis_Homo sapiens_hsa05134 | 0.53329765 |
| 91 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.53284768 |
| 92 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.52871062 |
| 93 | Base excision repair_Homo sapiens_hsa03410 | 0.52834888 |
| 94 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.52309139 |
| 95 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.49903232 |
| 96 | Tuberculosis_Homo sapiens_hsa05152 | 0.48081609 |
| 97 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.44835391 |
| 98 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.42244178 |
| 99 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.42060937 |
| 100 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.42034935 |
| 101 | Pertussis_Homo sapiens_hsa05133 | 0.41025379 |
| 102 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.39989033 |
| 103 | Pathways in cancer_Homo sapiens_hsa05200 | 0.36988613 |
| 104 | Malaria_Homo sapiens_hsa05144 | 0.36398646 |
| 105 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.35500449 |
| 106 | Endocytosis_Homo sapiens_hsa04144 | 0.35290813 |
| 107 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.35242518 |
| 108 | Insulin resistance_Homo sapiens_hsa04931 | 0.32240608 |
| 109 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.32238094 |
| 110 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 0.30798026 |
| 111 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.30669714 |
| 112 | Phagosome_Homo sapiens_hsa04145 | 0.29837245 |
| 113 | Salmonella infection_Homo sapiens_hsa05132 | 0.29470189 |
| 114 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.27468684 |
| 115 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.26970060 |
| 116 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.25195356 |
| 117 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.23993537 |
| 118 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 0.23224779 |
| 119 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.22212350 |
| 120 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.22178871 |
| 121 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.20611040 |
| 122 | Protein export_Homo sapiens_hsa03060 | 0.18329858 |
| 123 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.16241855 |
| 124 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.16213076 |
| 125 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.15098078 |
| 126 | Circadian rhythm_Homo sapiens_hsa04710 | 0.13074912 |
| 127 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.12173706 |

