TRBV20-1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative T cell selection (GO:0043383)7.13303980
2positive regulation of gamma-delta T cell activation (GO:0046645)6.77746393
3negative thymic T cell selection (GO:0045060)6.76356114
4positive regulation of interleukin-2 biosynthetic process (GO:0045086)6.47669828
5positive regulation of natural killer cell mediated immunity (GO:0002717)6.37837424
6positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)6.28751282
7regulation of natural killer cell mediated cytotoxicity (GO:0042269)5.99249899
8regulation of natural killer cell mediated immunity (GO:0002715)5.99249899
9thymic T cell selection (GO:0045061)5.87794884
10antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.81264424
11regulation of gamma-delta T cell differentiation (GO:0045586)5.78424188
12antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.57815822
13mucosal-associated lymphoid tissue development (GO:0048537)5.57744156
14Peyers patch development (GO:0048541)5.57744156
15positive T cell selection (GO:0043368)5.43669700
16antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.36090682
17positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.33442390
18positive thymic T cell selection (GO:0045059)5.33089541
19antigen processing and presentation of endogenous antigen (GO:0019883)5.09098450
20regulation of B cell receptor signaling pathway (GO:0050855)5.08934521
21T cell selection (GO:0045058)5.07672524
22regulation of interleukin-2 biosynthetic process (GO:0045076)4.99446135
23negative regulation of cell killing (GO:0031342)4.98284247
24negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.98284247
25leukocyte aggregation (GO:0070486)4.93287300
26regulation of gamma-delta T cell activation (GO:0046643)4.85718607
27response to interleukin-15 (GO:0070672)4.83525049
28Arp2/3 complex-mediated actin nucleation (GO:0034314)4.79983056
29regulation of regulatory T cell differentiation (GO:0045589)4.78405573
30positive regulation of granulocyte differentiation (GO:0030854)4.77076224
31tolerance induction (GO:0002507)4.70139727
32T cell migration (GO:0072678)4.62680808
33positive regulation of B cell differentiation (GO:0045579)4.56175913
34regulation of T cell tolerance induction (GO:0002664)4.51915769
35cellular response to interleukin-15 (GO:0071350)4.45412190
36positive regulation of leukocyte mediated cytotoxicity (GO:0001912)4.34656321
37regulation of isotype switching to IgG isotypes (GO:0048302)4.16739697
38positive regulation of tolerance induction (GO:0002645)4.05694686
39regulation of leukocyte mediated cytotoxicity (GO:0001910)3.99021297
40regulation of histone H3-K27 methylation (GO:0061085)3.97497110
41T cell receptor signaling pathway (GO:0050852)3.96235831
42positive regulation of alpha-beta T cell proliferation (GO:0046641)3.84051701
43regulation of defense response to virus by virus (GO:0050690)3.83568968
44actin nucleation (GO:0045010)3.81905510
45regulation of B cell differentiation (GO:0045577)3.80553418
46positive regulation of cell killing (GO:0031343)3.80020962
47mast cell activation (GO:0045576)3.78222409
48antigen processing and presentation via MHC class Ib (GO:0002475)3.68461834
49regulation of alpha-beta T cell proliferation (GO:0046640)3.66049942
50cellular response to interleukin-4 (GO:0071353)3.65520101
51positive regulation of interleukin-4 production (GO:0032753)3.65474505
52T cell costimulation (GO:0031295)3.64388347
53lymphocyte costimulation (GO:0031294)3.60640340
54natural killer cell differentiation (GO:0001779)3.60470358
55regulation of tolerance induction (GO:0002643)3.58743891
56antigen receptor-mediated signaling pathway (GO:0050851)3.50685084
57regulation of cell killing (GO:0031341)3.47641415
58positive regulation of natural killer cell differentiation (GO:0032825)3.46647902
59regulation of interleukin-4 production (GO:0032673)3.44395878
60negative regulation of erythrocyte differentiation (GO:0045647)3.37743851
61response to interleukin-4 (GO:0070670)3.31484304
62viral transcription (GO:0019083)3.30312174
63signal complex assembly (GO:0007172)3.29849301
64V(D)J recombination (GO:0033151)3.22802554
65negative regulation of lymphocyte mediated immunity (GO:0002707)3.22374724
66positive regulation of interleukin-2 production (GO:0032743)3.18544920
67mast cell activation involved in immune response (GO:0002279)3.12010733
68mast cell degranulation (GO:0043303)3.12010733
69regulation of granulocyte differentiation (GO:0030852)3.11983505
70melanin metabolic process (GO:0006582)3.09112041
71melanin biosynthetic process (GO:0042438)3.08568931
72translational termination (GO:0006415)3.04072650
73positive regulation of lymphocyte mediated immunity (GO:0002708)3.03581904
74negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.01492761
75T cell differentiation (GO:0030217)2.98132834
76negative regulation of T cell apoptotic process (GO:0070233)2.96300000
77regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.95417712
78natural killer cell activation (GO:0030101)2.91693540
79regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.89699556
80regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.88089175
81positive regulation of humoral immune response (GO:0002922)2.87061543
82positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.86881083
83positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.86764004
84translational elongation (GO:0006414)2.85819435
85T cell homeostasis (GO:0043029)2.83756327
86ribosomal small subunit assembly (GO:0000028)2.81567335
87positive regulation of T cell mediated cytotoxicity (GO:0001916)2.80299419
88positive regulation of alpha-beta T cell activation (GO:0046635)2.80014514
89B cell receptor signaling pathway (GO:0050853)2.79651358
90negative regulation of T cell mediated immunity (GO:0002710)2.77607834
91regulation of interleukin-2 production (GO:0032663)2.77194909
92lymphocyte migration (GO:0072676)2.76893169
93negative regulation of leukocyte mediated immunity (GO:0002704)2.71370752
94immune response-activating cell surface receptor signaling pathway (GO:0002429)2.68511990
95regulation of T cell mediated cytotoxicity (GO:0001914)2.67208314
96SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.64290236
97positive regulation of macrophage differentiation (GO:0045651)2.63519181
98regulation of alpha-beta T cell activation (GO:0046634)2.61940556
99regulation of lymphocyte mediated immunity (GO:0002706)2.60809433
100positive regulation of leukocyte mediated immunity (GO:0002705)2.58833738

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.27229165
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.24085960
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.61910911
4MYC_22102868_ChIP-Seq_BL_Human3.55288262
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.08595864
6MYB_26560356_Chip-Seq_TH2_Human2.95696211
7RUNX_20019798_ChIP-Seq_JUKART_Human2.82503226
8UTX_26944678_Chip-Seq_JUKART_Human2.73862710
9MAF_26560356_Chip-Seq_TH1_Human2.70092177
10STAT4_19710469_ChIP-ChIP_TH1__Mouse2.43224591
11MAF_26560356_Chip-Seq_TH2_Human2.34014146
12IRF8_22096565_ChIP-ChIP_GC-B_Human2.25742997
13STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.23704963
14IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.22206118
15SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.21641725
16KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.19992498
17MYB_26560356_Chip-Seq_TH1_Human2.19984463
18MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.18480592
19VDR_21846776_ChIP-Seq_THP-1_Human2.13671964
20FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.12820924
21NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.10148348
22RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.06724073
23TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.01496313
24TCF7_22412390_ChIP-Seq_EML_Mouse1.99907642
25EGR1_19374776_ChIP-ChIP_THP-1_Human1.97538366
26KDM2B_26808549_Chip-Seq_DND41_Human1.91685602
27IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.90682003
28CIITA_25753668_ChIP-Seq_RAJI_Human1.90134271
29KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.89158225
30TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.86859762
31ELF1_17652178_ChIP-ChIP_JURKAT_Human1.86408915
32SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.78122888
33GATA3_27048872_Chip-Seq_THYMUS_Human1.76843621
34NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.74637008
35E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.72962917
36MYC_18555785_ChIP-Seq_MESCs_Mouse1.72111445
37RUNX1_22412390_ChIP-Seq_EML_Mouse1.71365537
38HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.68714212
39VDR_24763502_ChIP-Seq_THP-1_Human1.68602432
40ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.66077865
41KDM2B_26808549_Chip-Seq_SUP-B15_Human1.63464087
42BRD4_27068464_Chip-Seq_AML-cells_Mouse1.62388540
43SPI1_23547873_ChIP-Seq_NB4_Human1.61926367
44FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.58045544
45SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.57321647
46MYC_19079543_ChIP-ChIP_MESCs_Mouse1.56793649
47IRF8_21731497_ChIP-ChIP_J774_Mouse1.54919575
48ELK3_25401928_ChIP-Seq_HUVEC_Human1.54217665
49LXR_22292898_ChIP-Seq_THP-1_Human1.54211983
50MYB_21317192_ChIP-Seq_ERMYB_Mouse1.45414146
51MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.42385757
52XRN2_22483619_ChIP-Seq_HELA_Human1.38381687
53SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.37166278
54NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.36425868
55FOXM1_23109430_ChIP-Seq_U2OS_Human1.33819107
56SCL_19346495_ChIP-Seq_HPC-7_Human1.32826569
57THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.32649347
58TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.31072904
59NCOR1_26117541_ChIP-Seq_K562_Human1.27257269
60P68_20966046_ChIP-Seq_HELA_Human1.26707299
61RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.26091747
62MYC_18358816_ChIP-ChIP_MESCs_Mouse1.25943879
63KDM2B_26808549_Chip-Seq_JURKAT_Human1.25428531
64MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.21551180
65CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.20857935
66CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.19417625
67HIF1A_21447827_ChIP-Seq_MCF-7_Human1.18302965
68ELF1_20517297_ChIP-Seq_JURKAT_Human1.17975698
69HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.17691129
70SPI1_23127762_ChIP-Seq_K562_Human1.16423399
71ZNF263_19887448_ChIP-Seq_K562_Human1.15156585
72YY1_21170310_ChIP-Seq_MESCs_Mouse1.13611097
73PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.13536126
74MYC_19030024_ChIP-ChIP_MESCs_Mouse1.13005727
75CTCF_27219007_Chip-Seq_ERYTHROID_Human1.12414308
76CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.11282686
77FOXP3_21729870_ChIP-Seq_TREG_Human1.10226774
78STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.06924425
79GATA1_22383799_ChIP-Seq_G1ME_Mouse1.06105583
80GATA2_22383799_ChIP-Seq_G1ME_Mouse1.03864876
81SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.03809162
82RACK7_27058665_Chip-Seq_MCF-7_Human1.01207093
83E2F4_17652178_ChIP-ChIP_JURKAT_Human0.99860646
84BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.99470259
85PKCTHETA_26484144_Chip-Seq_BREAST_Human0.98472496
86SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97352931
87ZFP281_18757296_ChIP-ChIP_E14_Mouse0.96236255
88SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.96041734
89SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.95444229
90CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95223354
91PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94916104
92SA1_27219007_Chip-Seq_ERYTHROID_Human0.94505701
93BCOR_27268052_Chip-Seq_Bcells_Human0.94139789
94VDR_23849224_ChIP-Seq_CD4+_Human0.94087413
95BCL6_27268052_Chip-Seq_Bcells_Human0.93063445
96NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.92973899
97SMC4_20622854_ChIP-Seq_HELA_Human0.92264186
98ETS1_21867929_ChIP-Seq_TH2_Mouse0.91471990
99LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.91400831
100IRF8_27001747_Chip-Seq_BMDM_Mouse0.90391129

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology5.27840868
2MP0005671_abnormal_response_to4.44212847
3MP0004381_abnormal_hair_follicle3.49113118
4MP0009333_abnormal_splenocyte_physiolog3.18834139
5MP0001835_abnormal_antigen_presentation3.05423849
6MP0000703_abnormal_thymus_morphology3.05021141
7MP0000685_abnormal_immune_system2.80134632
8MP0001873_stomach_inflammation2.78064601
9MP0005000_abnormal_immune_tolerance2.77289906
10MP0003436_decreased_susceptibility_to2.52059677
11MP0002398_abnormal_bone_marrow2.48869474
12MP0005075_abnormal_melanosome_morpholog2.46807316
13MP0001800_abnormal_humoral_immune2.37156312
14MP0002420_abnormal_adaptive_immunity2.34013395
15MP0009785_altered_susceptibility_to2.30217645
16MP0002396_abnormal_hematopoietic_system2.29414927
17MP0002405_respiratory_system_inflammati2.26386598
18MP0005451_abnormal_body_composition2.26066253
19MP0005025_abnormal_response_to2.25888432
20MP0001819_abnormal_immune_cell2.25830664
21MP0005171_absent_coat_pigmentation2.21485725
22MP0002166_altered_tumor_susceptibility2.15660870
23MP0002722_abnormal_immune_system2.11000053
24MP0002723_abnormal_immune_serum2.09902566
25MP0001790_abnormal_immune_system2.09555262
26MP0005387_immune_system_phenotype2.09555262
27MP0003300_gastrointestinal_ulcer2.07762622
28MP0003866_abnormal_defecation2.06414047
29MP0000716_abnormal_immune_system2.05741973
30MP0001853_heart_inflammation1.95595252
31MP0002009_preneoplasia1.94386776
32MP0000689_abnormal_spleen_morphology1.84277390
33MP0002877_abnormal_melanocyte_morpholog1.78911798
34MP0010155_abnormal_intestine_physiology1.77483443
35MP0002429_abnormal_blood_cell1.76555790
36MP0008438_abnormal_cutaneous_collagen1.73988315
37MP0002452_abnormal_antigen_presenting1.72596824
38MP0004947_skin_inflammation1.71554618
39MP0002933_joint_inflammation1.69115279
40MP0002419_abnormal_innate_immunity1.58035962
41MP0001348_abnormal_lacrimal_gland1.57118517
42MP0006082_CNS_inflammation1.56472621
43MP0002006_tumorigenesis1.50365869
44MP0000490_abnormal_crypts_of1.47479416
45MP0003123_paternal_imprinting1.47077247
46MP0002148_abnormal_hypersensitivity_rea1.42568121
47MP0000858_altered_metastatic_potential1.41874974
48MP0003111_abnormal_nucleus_morphology1.38666391
49MP0005464_abnormal_platelet_physiology1.37255463
50MP0003567_abnormal_fetal_cardiomyocyte1.33249853
51MP0008260_abnormal_autophagy1.33114447
52MP0003724_increased_susceptibility_to1.31948498
53MP0004808_abnormal_hematopoietic_stem1.30969928
54MP0003787_abnormal_imprinting1.26916657
55MP0000678_abnormal_parathyroid_gland1.25353827
56MP0001845_abnormal_inflammatory_respons1.23273624
57MP0008569_lethality_at_weaning1.19168125
58MP0002019_abnormal_tumor_incidence1.17140484
59MP0002132_abnormal_respiratory_system1.16077183
60MP0001851_eye_inflammation1.15074743
61MP0009278_abnormal_bone_marrow1.03180803
62MP0003448_altered_tumor_morphology1.02561692
63MP0005310_abnormal_salivary_gland0.98357862
64MP0005408_hypopigmentation0.97887626
65MP0010094_abnormal_chromosome_stability0.96709889
66MP0000372_irregular_coat_pigmentation0.96667093
67MP0001533_abnormal_skeleton_physiology0.93267232
68MP0003303_peritoneal_inflammation0.89050644
69MP0004957_abnormal_blastocyst_morpholog0.81105486
70MP0008469_abnormal_protein_level0.80645460
71MP0000371_diluted_coat_color0.80229091
72MP0003172_abnormal_lysosome_physiology0.78031842
73MP0003315_abnormal_perineum_morphology0.77101688
74MP0003045_fibrosis0.76961014
75MP0003943_abnormal_hepatobiliary_system0.73978207
76MP0009763_increased_sensitivity_to0.70349629
77MP0000465_gastrointestinal_hemorrhage0.70349402
78MP0002693_abnormal_pancreas_physiology0.69883641
79MP0005058_abnormal_lysosome_morphology0.69559619
80MP0002075_abnormal_coat/hair_pigmentati0.64356394
81MP0000313_abnormal_cell_death0.64055748
82MP0005166_decreased_susceptibility_to0.63540409
83MP0000350_abnormal_cell_proliferation0.63009146
84MP0001663_abnormal_digestive_system0.61141208
85MP0008877_abnormal_DNA_methylation0.60510537
86MP0003959_abnormal_lean_body0.60025752
87MP0002089_abnormal_postnatal_growth/wei0.59756242
88MP0000920_abnormal_myelination0.57128943
89MP0001849_ear_inflammation0.56765225
90MP0003786_premature_aging0.56434760
91MP0001919_abnormal_reproductive_system0.56002748
92MP0003077_abnormal_cell_cycle0.54109208
93MP0000639_abnormal_adrenal_gland0.53536141
94MP0001661_extended_life_span0.52880231
95MP0002083_premature_death0.52756382
96MP0005423_abnormal_somatic_nervous0.52479679
97MP0004185_abnormal_adipocyte_glucose0.50763686
98MP0001502_abnormal_circadian_rhythm0.49199140
99MP0002970_abnormal_white_adipose0.49194595
100MP0000477_abnormal_intestine_morphology0.48889790

Predicted human phenotypes

RankGene SetZ-score
1Severe combined immunodeficiency (HP:0004430)5.69052886
2T lymphocytopenia (HP:0005403)5.17453907
3Autoimmune hemolytic anemia (HP:0001890)4.89506108
4Combined immunodeficiency (HP:0005387)4.69232830
5Abnormality of T cell number (HP:0011839)4.47500810
6Increased IgM level (HP:0003496)4.01896017
7Eczematoid dermatitis (HP:0000976)4.00798568
8Elevated erythrocyte sedimentation rate (HP:0003565)3.92155126
9Cholecystitis (HP:0001082)3.80257954
10Abnormal gallbladder physiology (HP:0012438)3.80257954
11Aplastic anemia (HP:0001915)3.70032155
12Obstructive lung disease (HP:0006536)3.62969683
13Chronic obstructive pulmonary disease (HP:0006510)3.62969683
14IgG deficiency (HP:0004315)3.37582519
15Abnormality of T cells (HP:0002843)3.36117854
16Encephalitis (HP:0002383)3.29107940
17Abnormality of macrophages (HP:0004311)3.28475348
18Meningitis (HP:0001287)3.22161432
19Hypoplasia of the thymus (HP:0000778)3.17098219
20Lymphopenia (HP:0001888)2.91968278
21Recurrent fungal infections (HP:0002841)2.88504610
22Myositis (HP:0100614)2.87287304
23Increased IgE level (HP:0003212)2.84764040
24Slow saccadic eye movements (HP:0000514)2.81156703
25Abnormality of cells of the lymphoid lineage (HP:0012140)2.76354657
26Panhypogammaglobulinemia (HP:0003139)2.72770059
27Lymphoma (HP:0002665)2.72579942
28J-shaped sella turcica (HP:0002680)2.69406544
29Chest pain (HP:0100749)2.68199885
30B lymphocytopenia (HP:0010976)2.68022244
31Fatigue (HP:0012378)2.65274432
32Chronic diarrhea (HP:0002028)2.64893313
33Stomatitis (HP:0010280)2.57811816
34Hypoproteinemia (HP:0003075)2.52113209
35Abnormality of the fingertips (HP:0001211)2.48931815
36Abnormality of binocular vision (HP:0011514)2.48345604
37Diplopia (HP:0000651)2.48345604
38Granulocytopenia (HP:0001913)2.48204191
39Pustule (HP:0200039)2.47672668
40Growth hormone excess (HP:0000845)2.45445257
41Gastrointestinal infarctions (HP:0005244)2.44759064
42Hypergammaglobulinemia (HP:0010702)2.44703332
43Abnormality of eosinophils (HP:0001879)2.44274374
44Aplasia/Hypoplasia of the thymus (HP:0010515)2.43628765
45Thyroiditis (HP:0100646)2.42419790
46Abnormality of B cell number (HP:0010975)2.39779480
47Mediastinal lymphadenopathy (HP:0100721)2.38313958
48Spontaneous hematomas (HP:0007420)2.36760526
49Recurrent viral infections (HP:0004429)2.35351856
50Vasculitis (HP:0002633)2.35254892
51Pulmonary embolism (HP:0002204)2.33158893
52Recurrent bronchitis (HP:0002837)2.22866351
53Pulmonary infiltrates (HP:0002113)2.18827506
54Hypochromic microcytic anemia (HP:0004840)2.17653458
55Orchitis (HP:0100796)2.15087362
56Optic neuritis (HP:0100653)2.13084216
57Retrobulbar optic neuritis (HP:0100654)2.13084216
58Abnormal delayed hypersensitivity skin test (HP:0002963)2.12030571
59Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.11447810
60Gastrointestinal inflammation (HP:0004386)2.11283275
61Recurrent cutaneous fungal infections (HP:0011370)2.10995238
62Chronic mucocutaneous candidiasis (HP:0002728)2.10995238
63Glomerulopathy (HP:0100820)2.10664352
64Deep palmar crease (HP:0006191)2.08935838
65Abnormality of oral frenula (HP:0000190)2.07131859
66Reticulocytosis (HP:0001923)2.04757757
67Joint swelling (HP:0001386)2.04618505
68Acute hepatic failure (HP:0006554)2.03261648
69Micronodular cirrhosis (HP:0001413)2.02897747
70Annular pancreas (HP:0001734)2.02603102
71Spinal canal stenosis (HP:0003416)1.98112614
72Hypochromic anemia (HP:0001931)1.97206176
73Pallor (HP:0000980)1.95137908
74Agammaglobulinemia (HP:0004432)1.93614456
75Abnormality of reticulocytes (HP:0004312)1.93018169
76Ocular albinism (HP:0001107)1.92876425
77Premature graying of hair (HP:0002216)1.91956846
78Keratoconjunctivitis sicca (HP:0001097)1.90967354
79Recurrent bacterial skin infections (HP:0005406)1.89372435
80Recurrent abscess formation (HP:0002722)1.88875630
81Glucose intolerance (HP:0000833)1.88801533
82Cerebral aneurysm (HP:0004944)1.88321982
83Leukocytosis (HP:0001974)1.87618687
84Abnormality of T cell physiology (HP:0011840)1.87014575
85Epistaxis (HP:0000421)1.86985380
86Morphological abnormality of the inner ear (HP:0011390)1.86684644
87Eosinophilia (HP:0001880)1.86052809
88Seborrheic dermatitis (HP:0001051)1.84326171
89Ureteral stenosis (HP:0000071)1.82464520
90Broad palm (HP:0001169)1.82084235
91Trigonocephaly (HP:0000243)1.81778021
92Vertebral compression fractures (HP:0002953)1.80222680
93Segmental peripheral demyelination/remyelination (HP:0003481)1.79401840
94Asymmetry of the thorax (HP:0001555)1.78607373
95Microvesicular hepatic steatosis (HP:0001414)1.78018294
96Hemoptysis (HP:0002105)1.76398371
97Abnormality of the common coagulation pathway (HP:0010990)1.74581811
98Gastrointestinal dysmotility (HP:0002579)1.74471891
99Hepatitis (HP:0012115)1.71774336
100Keratoconjunctivitis (HP:0001096)1.71415549

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK4.35007175
2TESK23.21224051
3MAP4K13.11942181
4EEF2K2.48398483
5ZAP702.40211386
6TRIB32.32061275
7PRPF4B2.22431123
8ITK2.18734812
9FGFR42.18620854
10TYRO32.13924516
11KDR2.13098533
12SCYL21.83560060
13CAMKK11.79673503
14PASK1.79481680
15KSR21.78374830
16SMG11.68832785
17FES1.63987080
18TYK21.63232700
19BTK1.62277031
20GRK61.58873031
21CDK61.54785151
22PKN21.53905229
23CDK191.49428433
24LCK1.48046523
25MAPK111.47194376
26SYK1.38547165
27SIK31.37682286
28RIPK41.37361903
29SIK21.36367173
30WEE11.35356660
31ERN11.34275384
32CDK41.33689722
33MAP3K131.33461464
34FGFR31.32147155
35TESK11.31527197
36JAK31.26607960
37CDK121.21572009
38LRRK21.17799906
39MAP3K21.16558608
40JAK21.15442887
41TLK11.14279146
42CAMKK21.12991645
43RPS6KB21.12944032
44UHMK11.10132228
45NLK1.10058232
46ICK1.09738094
47MAP2K61.05733458
48TNK21.03194801
49TRPM71.00441257
50MAPK120.99159887
51FGFR20.98972906
52HCK0.98185110
53PRKD30.98153353
54CSK0.96550277
55MARK30.91231825
56SIK10.86256436
57MAP3K30.86170273
58HIPK20.85547686
59PDK10.79757120
60PTK60.77383664
61LYN0.74134703
62NTRK20.73976939
63RAF10.73385932
64PRKCH0.72898668
65MAP3K100.72736931
66FYN0.67808109
67EIF2AK10.65554380
68MAP3K10.63555823
69TEC0.63348062
70PAK10.61805445
71RPS6KA40.60568470
72BRSK10.59773960
73MAP3K80.57088391
74MAP2K30.56412417
75CLK10.50930070
76CDK140.50078906
77MARK20.49665445
78TAOK30.48594118
79CDK11A0.47360495
80NEK60.47034344
81PDPK10.46401560
82STK100.45861259
83IKBKE0.45378439
84WNK10.44999099
85CDK80.44913069
86CDK70.43976145
87BUB10.42775302
88PIM10.41541918
89ARAF0.41116535
90CDK150.40956022
91VRK10.40553383
92ALK0.40257291
93IRAK40.39424098
94MAP3K110.39172289
95RET0.37796243
96CDK180.37709021
97JAK10.37301254
98LIMK10.35653630
99WNK40.35584742
100PRKCQ0.35260104

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.77171697
2T cell receptor signaling pathway_Homo sapiens_hsa046603.64784406
3Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046503.12788689
4Hematopoietic cell lineage_Homo sapiens_hsa046402.55514976
5Measles_Homo sapiens_hsa051622.29855787
6Autoimmune thyroid disease_Homo sapiens_hsa053202.13304328
7Acute myeloid leukemia_Homo sapiens_hsa052212.13058485
8DNA replication_Homo sapiens_hsa030302.09461828
9Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.96893044
10Allograft rejection_Homo sapiens_hsa053301.91319399
11Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.84584370
12Graft-versus-host disease_Homo sapiens_hsa053321.83536210
13Malaria_Homo sapiens_hsa051441.81463601
14Ribosome_Homo sapiens_hsa030101.79426553
15Antigen processing and presentation_Homo sapiens_hsa046121.66494844
16Non-small cell lung cancer_Homo sapiens_hsa052231.66421573
17Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.61254744
18Chronic myeloid leukemia_Homo sapiens_hsa052201.51571105
19B cell receptor signaling pathway_Homo sapiens_hsa046621.45407234
20Pentose phosphate pathway_Homo sapiens_hsa000301.42368889
21Type I diabetes mellitus_Homo sapiens_hsa049401.40896483
22Viral myocarditis_Homo sapiens_hsa054161.38475570
23Thyroid cancer_Homo sapiens_hsa052161.37392788
24VEGF signaling pathway_Homo sapiens_hsa043701.35771082
25Shigellosis_Homo sapiens_hsa051311.24532761
26Biosynthesis of amino acids_Homo sapiens_hsa012301.19751956
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.17231189
28Other glycan degradation_Homo sapiens_hsa005111.14857162
29Spliceosome_Homo sapiens_hsa030401.14496574
30Colorectal cancer_Homo sapiens_hsa052101.13262878
31NF-kappa B signaling pathway_Homo sapiens_hsa040641.12677571
32Hepatitis B_Homo sapiens_hsa051611.12190047
33Long-term potentiation_Homo sapiens_hsa047201.11754350
34Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.09737217
35Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.09462474
36Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.08692920
37HTLV-I infection_Homo sapiens_hsa051661.07919381
38Osteoclast differentiation_Homo sapiens_hsa043801.06550672
39Proteasome_Homo sapiens_hsa030501.04110745
40Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.03557922
41Endometrial cancer_Homo sapiens_hsa052131.02048588
42Central carbon metabolism in cancer_Homo sapiens_hsa052301.00304951
43Pancreatic cancer_Homo sapiens_hsa052120.99558650
44Nitrogen metabolism_Homo sapiens_hsa009100.97724821
45Herpes simplex infection_Homo sapiens_hsa051680.97327176
46Prion diseases_Homo sapiens_hsa050200.94149779
47Epstein-Barr virus infection_Homo sapiens_hsa051690.93180514
48Chemokine signaling pathway_Homo sapiens_hsa040620.92825274
49Leishmaniasis_Homo sapiens_hsa051400.92778039
50Fructose and mannose metabolism_Homo sapiens_hsa000510.92683292
51Legionellosis_Homo sapiens_hsa051340.92298070
52HIF-1 signaling pathway_Homo sapiens_hsa040660.91936427
53Viral carcinogenesis_Homo sapiens_hsa052030.88998711
54Jak-STAT signaling pathway_Homo sapiens_hsa046300.87344313
55Cell cycle_Homo sapiens_hsa041100.86428782
56Glioma_Homo sapiens_hsa052140.83312983
57Renal cell carcinoma_Homo sapiens_hsa052110.77384847
58mRNA surveillance pathway_Homo sapiens_hsa030150.77284208
59Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.74935261
60ErbB signaling pathway_Homo sapiens_hsa040120.74700968
61Base excision repair_Homo sapiens_hsa034100.71609849
62Endocytosis_Homo sapiens_hsa041440.69888235
63Salmonella infection_Homo sapiens_hsa051320.69871765
64Toll-like receptor signaling pathway_Homo sapiens_hsa046200.68538621
65Apoptosis_Homo sapiens_hsa042100.64165829
66Carbohydrate digestion and absorption_Homo sapiens_hsa049730.62146491
67Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.59611394
68Influenza A_Homo sapiens_hsa051640.58341782
69African trypanosomiasis_Homo sapiens_hsa051430.57588123
70Neurotrophin signaling pathway_Homo sapiens_hsa047220.57446317
71Phosphatidylinositol signaling system_Homo sapiens_hsa040700.55845470
72Prostate cancer_Homo sapiens_hsa052150.55390543
73Prolactin signaling pathway_Homo sapiens_hsa049170.54329709
74NOD-like receptor signaling pathway_Homo sapiens_hsa046210.54018626
75Thyroid hormone signaling pathway_Homo sapiens_hsa049190.53546113
76Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.53532475
77Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.53452200
78Galactose metabolism_Homo sapiens_hsa000520.52901876
79mTOR signaling pathway_Homo sapiens_hsa041500.52429166
80Platelet activation_Homo sapiens_hsa046110.52208718
81RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.51232683
82Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.50121561
83AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.49200440
84Intestinal immune network for IgA production_Homo sapiens_hsa046720.48687255
85Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.47375782
86Tuberculosis_Homo sapiens_hsa051520.43976909
87One carbon pool by folate_Homo sapiens_hsa006700.43510959
88SNARE interactions in vesicular transport_Homo sapiens_hsa041300.41952892
89Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.41805467
90Leukocyte transendothelial migration_Homo sapiens_hsa046700.41796779
91Sphingolipid signaling pathway_Homo sapiens_hsa040710.40660035
92RNA transport_Homo sapiens_hsa030130.38094827
93Carbon metabolism_Homo sapiens_hsa012000.37837234
94N-Glycan biosynthesis_Homo sapiens_hsa005100.37465700
95Choline metabolism in cancer_Homo sapiens_hsa052310.37253930
96Phospholipase D signaling pathway_Homo sapiens_hsa040720.36751764
97Pertussis_Homo sapiens_hsa051330.36582054
98Insulin signaling pathway_Homo sapiens_hsa049100.36466990
99Regulation of actin cytoskeleton_Homo sapiens_hsa048100.36228382
100Mismatch repair_Homo sapiens_hsa034300.34066051

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