ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)	8.57053957
2	positive regulation of natural killer cell mediated immunity (GO:0002717)	8.29391784
3	regulation of B cell receptor signaling pathway (GO:0050855)	7.61777421
4	regulation of natural killer cell mediated immunity (GO:0002715)	7.17756480
5	regulation of natural killer cell mediated cytotoxicity (GO:0042269)	7.17756480
6	Arp2/3 complex-mediated actin nucleation (GO:0034314)	7.14966751
7	negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)	6.79180275
8	actin nucleation (GO:0045010)	6.27905752
9	erythrocyte maturation (GO:0043249)	5.62654013
10	positive regulation of leukocyte mediated cytotoxicity (GO:0001912)	5.47955466
11	negative regulation of execution phase of apoptosis (GO:1900118)	5.38427801
12	fusion of sperm to egg plasma membrane (GO:0007342)	5.30034960
13	erythrocyte development (GO:0048821)	4.97347104
14	cytolysis (GO:0019835)	4.96751329
15	regulation of leukocyte mediated cytotoxicity (GO:0001910)	4.95993120
16	sphingomyelin metabolic process (GO:0006684)	4.93438465
17	positive regulation of cell killing (GO:0031343)	4.81411789
18	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	4.69907923
19	sulfation (GO:0051923)	4.68188253
20	positive thymic T cell selection (GO:0045059)	4.61156535
21	positive T cell selection (GO:0043368)	4.47931273
22	mast cell degranulation (GO:0043303)	4.45778402
23	mast cell activation involved in immune response (GO:0002279)	4.45778402
24	negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)	4.38338941
25	regulation of cell killing (GO:0031341)	4.36260697
26	iron-sulfur cluster assembly (GO:0016226)	4.35045196
27	metallo-sulfur cluster assembly (GO:0031163)	4.35045196
28	cellular response to interleukin-15 (GO:0071350)	4.30322322
29	negative regulation of monooxygenase activity (GO:0032769)	4.27818623
30	cytidine metabolic process (GO:0046087)	4.22573024
31	cytidine catabolic process (GO:0006216)	4.22573024
32	cytidine deamination (GO:0009972)	4.22573024
33	protoporphyrinogen IX metabolic process (GO:0046501)	4.22304652
34	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	4.18292387
35	auditory receptor cell differentiation (GO:0042491)	4.09223078
36	positive regulation of interleukin-8 secretion (GO:2000484)	4.08733085
37	regulation of transmission of nerve impulse (GO:0051969)	3.98117008
38	oxygen transport (GO:0015671)	3.96854023
39	natural killer cell activation (GO:0030101)	3.96410857
40	hemoglobin metabolic process (GO:0020027)	3.94689205
41	plasma membrane fusion (GO:0045026)	3.93882369
42	negative regulation of stress fiber assembly (GO:0051497)	3.87098303
43	deoxyribonucleoside diphosphate metabolic process (GO:0009186)	3.86930551
44	negative regulation of oxidoreductase activity (GO:0051354)	3.85624330
45	negative T cell selection (GO:0043383)	3.85506375
46	protein maturation by protein folding (GO:0022417)	3.84601218
47	pyrimidine ribonucleoside catabolic process (GO:0046133)	3.83241953
48	mitochondrial calcium ion transport (GO:0006851)	3.78795222
49	DNA deamination (GO:0045006)	3.78190511
50	termination of RNA polymerase III transcription (GO:0006386)	3.75036964
51	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.75036964
52	regulation of interleukin-8 secretion (GO:2000482)	3.73285424
53	thymic T cell selection (GO:0045061)	3.72347631
54	mast cell activation (GO:0045576)	3.69797487
55	regulation of vitamin D biosynthetic process (GO:0060556)	3.68161827
56	myeloid cell development (GO:0061515)	3.66034444
57	regulation of activation of Janus kinase activity (GO:0010533)	3.62871412
58	histone H2A acetylation (GO:0043968)	3.61888584
59	macrophage chemotaxis (GO:0048246)	3.59908122
60	positive regulation of cell fate commitment (GO:0010455)	3.52279099
61	T cell costimulation (GO:0031295)	3.50769278
62	lymphocyte costimulation (GO:0031294)	3.46599781
63	gas transport (GO:0015669)	3.45482502
64	C21-steroid hormone biosynthetic process (GO:0006700)	3.40986074
65	positive regulation of T cell apoptotic process (GO:0070234)	3.36379659
66	mitochondrial calcium ion homeostasis (GO:0051560)	3.31381416
67	negative regulation of T cell apoptotic process (GO:0070233)	3.31349143
68	protoporphyrinogen IX biosynthetic process (GO:0006782)	3.26373183
69	tetrapyrrole biosynthetic process (GO:0033014)	3.26150657
70	positive regulation of interleukin-2 biosynthetic process (GO:0045086)	3.25561801
71	transmission of nerve impulse (GO:0019226)	3.24825142
72	negative regulation of glial cell proliferation (GO:0060253)	3.24236088
73	T cell receptor signaling pathway (GO:0050852)	3.24199540
74	porphyrin-containing compound biosynthetic process (GO:0006779)	3.23332405
75	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	3.22271363
76	deoxyribose phosphate biosynthetic process (GO:0046385)	3.21617131
77	2-deoxyribonucleotide biosynthetic process (GO:0009265)	3.21617131
78	negative thymic T cell selection (GO:0045060)	3.13975729
79	respiratory burst (GO:0045730)	3.05028171
80	glycine transport (GO:0015816)	3.02094162
81	adenine nucleotide transport (GO:0051503)	3.02055940
82	NIK/NF-kappaB signaling (GO:0038061)	3.01406346
83	T cell selection (GO:0045058)	2.98007552
84	regulation of antigen receptor-mediated signaling pathway (GO:0050854)	2.96950566
85	sequestering of actin monomers (GO:0042989)	2.96139356
86	regulation of regulatory T cell differentiation (GO:0045589)	2.95908978
87	negative regulation of cell fate specification (GO:0009996)	2.94864146
88	negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)	2.93783860
89	positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr	2.93506720
90	antigen processing and presentation of endogenous peptide antigen (GO:0002483)	2.88813848
91	purine ribonucleotide transport (GO:0015868)	2.85040698
92	regulation of vitamin metabolic process (GO:0030656)	2.83851876
93	positive regulation of hair cycle (GO:0042635)	2.83434348
94	positive regulation of hair follicle development (GO:0051798)	2.83434348
95	regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)	2.83370961
96	leukocyte degranulation (GO:0043299)	2.82469729
97	porphyrin-containing compound metabolic process (GO:0006778)	2.81559284
98	antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)	2.81000405
99	positive regulation of protein homodimerization activity (GO:0090073)	2.79814589
100	lysosome localization (GO:0032418)	2.79411561

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	4.42591201
2	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	4.19357686
3	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	3.48704175
4	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	3.45555468
5	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	3.18512040
6	STAT6_21828071_ChIP-Seq_BEAS2B_Human	3.16100444
7	IRF8_21731497_ChIP-ChIP_J774_Mouse	3.07979908
8	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.87594712
9	MYB_26560356_Chip-Seq_TH2_Human	2.70651688
10	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	2.67163263
11	GATA1_19941826_ChIP-Seq_K562_Human	2.50863670
12	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.40269490
13	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.39512130
14	EZH2_22144423_ChIP-Seq_EOC_Human	2.37577263
15	HTT_18923047_ChIP-ChIP_STHdh_Human	2.23453336
16	STAT4_19710469_ChIP-ChIP_TH1__Mouse	2.13423851
17	UTX_26944678_Chip-Seq_JUKART_Human	2.04647404
18	FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse	1.99010932
19	MAF_26560356_Chip-Seq_TH1_Human	1.98968321
20	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.92277963
21	KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse	1.90257557
22	GATA3_27048872_Chip-Seq_THYMUS_Human	1.89515447
23	MEIS1_20887958_ChIP-Seq_HPC-7_Mouse	1.86547655
24	RUNX_20019798_ChIP-Seq_JUKART_Human	1.84986112
25	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.84299859
26	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.83860386
27	MAF_26560356_Chip-Seq_TH2_Human	1.83262534
28	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.83123371
29	GATA2_20887958_ChIP-Seq_HPC-7_Mouse	1.82811145
30	MECOM_23826213_ChIP-Seq_KASUMI_Mouse	1.80230863
31	VDR_22108803_ChIP-Seq_LS180_Human	1.79990487
32	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.79169722
33	VDR_23849224_ChIP-Seq_CD4+_Human	1.77140500
34	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.69007881
35	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.65427470
36	SCL_19346495_ChIP-Seq_HPC-7_Human	1.63224178
37	CIITA_25753668_ChIP-Seq_RAJI_Human	1.62079206
38	MYB_26560356_Chip-Seq_TH1_Human	1.60009263
39	STAT3_20064451_ChIP-Seq_CD4+T_Mouse	1.58289035
40	BCL6_27268052_Chip-Seq_Bcells_Human	1.54431774
41	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.49881846
42	FOXP3_21729870_ChIP-Seq_TREG_Human	1.48823304
43	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	1.46346308
44	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.44786343
45	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.44513900
46	IGF1R_20145208_ChIP-Seq_DFB_Human	1.37770302
47	ERG_20517297_ChIP-Seq_VCAP_Human	1.37575292
48	TAF2_19829295_ChIP-Seq_ESCs_Human	1.34429265
49	GATA2_19941826_ChIP-Seq_K562_Human	1.33550892
50	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.31857366
51	BCOR_27268052_Chip-Seq_Bcells_Human	1.29918297
52	CTCF_27219007_Chip-Seq_ERYTHROID_Human	1.28320335
53	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.26977225
54	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.26425736
55	GATA3_26560356_Chip-Seq_TH2_Human	1.25589218
56	E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	1.23516394
57	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.23387844
58	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.23386544
59	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.23353180
60	SA1_27219007_Chip-Seq_ERYTHROID_Human	1.19252244
61	P300_27268052_Chip-Seq_Bcells_Human	1.18624555
62	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.18472186
63	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.17918348
64	P53_21459846_ChIP-Seq_SAOS-2_Human	1.16227232
65	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.13182368
66	RUNX1_17652178_ChIP-ChIP_JURKAT_Human	1.12370955
67	GATA3_26560356_Chip-Seq_TH1_Human	1.10732989
68	P68_20966046_ChIP-Seq_HELA_Human	1.10532859
69	CTCF_21964334_ChIP-Seq_BJAB-B_Human	1.09677461
70	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.08113000
71	PHF8_20622854_ChIP-Seq_HELA_Human	1.07364160
72	CTCF_21964334_Chip-Seq_Bcells_Human	1.07116335
73	NANOG_20526341_ChIP-Seq_ESCs_Human	1.06798877
74	CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse	1.06098124
75	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.05720367
76	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.05715359
77	TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse	1.04308395
78	LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.03795164
79	CTCF_20526341_ChIP-Seq_ESCs_Human	1.02262383
80	ZNF263_19887448_ChIP-Seq_K562_Human	1.02167862
81	SA1_27219007_Chip-Seq_Bcells_Human	1.02144985
82	GATA1_22025678_ChIP-Seq_K562_Human	1.01762517
83	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.01485133
84	EGR1_19032775_ChIP-ChIP_M12_Human	0.98413958
85	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	0.96667156
86	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	0.96579232
87	RAD21_21589869_ChIP-Seq_MESCs_Mouse	0.96327487
88	GATA1_19941827_ChIP-Seq_MEL_Mouse	0.95778299
89	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.94993008
90	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	0.94988962
91	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.94840530
92	CTCF_27219007_Chip-Seq_Bcells_Human	0.94437649
93	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.94198368
94	TP53_22573176_ChIP-Seq_HFKS_Human	0.94100008
95	RUNX1_22412390_ChIP-Seq_EML_Mouse	0.92967589
96	GATA2_22383799_ChIP-Seq_G1ME_Mouse	0.92610945
97	NCOR_22424771_ChIP-Seq_293T_Human	0.92492179
98	RBPJ_21746931_ChIP-Seq_IB4_Human	0.91550560
99	GABP_17652178_ChIP-ChIP_JURKAT_Human	0.91148481
100	ETS1_22383799_ChIP-Seq_G1ME_Mouse	0.91141979

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005451_abnormal_body_composition	8.34573717
2	MP0005671_abnormal_response_to	5.41678030
3	MP0004147_increased_porphyrin_level	4.10556642
4	MP0001873_stomach_inflammation	3.44351963
5	MP0009785_altered_susceptibility_to	3.19521691
6	MP0003763_abnormal_thymus_physiology	3.17159608
7	MP0003283_abnormal_digestive_organ	2.81880750
8	MP0003656_abnormal_erythrocyte_physiolo	2.69084839
9	MP0008260_abnormal_autophagy	2.67711404
10	MP0003123_paternal_imprinting	2.43160566
11	MP0002166_altered_tumor_susceptibility	2.40509884
12	MP0001835_abnormal_antigen_presentation	2.26853432
13	MP0009333_abnormal_splenocyte_physiolog	2.05585463
14	MP0005000_abnormal_immune_tolerance	1.98440079
15	MP0002933_joint_inflammation	1.98127418
16	MP0005025_abnormal_response_to	1.94714247
17	MP0010155_abnormal_intestine_physiology	1.91623544
18	MP0003787_abnormal_imprinting	1.91268374
19	MP0004742_abnormal_vestibular_system	1.76548267
20	MP0002006_tumorigenesis	1.73180029
21	MP0001485_abnormal_pinna_reflex	1.64445487
22	MP0005083_abnormal_biliary_tract	1.59659300
23	MP0000858_altered_metastatic_potential	1.59650647
24	MP0008875_abnormal_xenobiotic_pharmacok	1.57813308
25	MP0002420_abnormal_adaptive_immunity	1.57314645
26	MP0005464_abnormal_platelet_physiology	1.55075553
27	MP0002405_respiratory_system_inflammati	1.54887548
28	MP0000685_abnormal_immune_system	1.54286468
29	MP0000703_abnormal_thymus_morphology	1.52835675
30	MP0001819_abnormal_immune_cell	1.52229850
31	MP0002398_abnormal_bone_marrow	1.48463846
32	MP0002723_abnormal_immune_serum	1.44380349
33	MP0003448_altered_tumor_morphology	1.43664895
34	MP0000689_abnormal_spleen_morphology	1.42715065
35	MP0001845_abnormal_inflammatory_respons	1.40541261
36	MP0004947_skin_inflammation	1.40099154
37	MP0002722_abnormal_immune_system	1.38246714
38	MP0003866_abnormal_defecation	1.32693858
39	MP0005377_hearing/vestibular/ear_phenot	1.31500276
40	MP0003878_abnormal_ear_physiology	1.31500276
41	MP0005645_abnormal_hypothalamus_physiol	1.30335213
42	MP0000716_abnormal_immune_system	1.28233304
43	MP0008004_abnormal_stomach_pH	1.27869072
44	MP0001800_abnormal_humoral_immune	1.24124500
45	MP0001905_abnormal_dopamine_level	1.23409394
46	MP0003567_abnormal_fetal_cardiomyocyte	1.22243608
47	MP0002132_abnormal_respiratory_system	1.22206664
48	MP0006082_CNS_inflammation	1.19997465
49	MP0005636_abnormal_mineral_homeostasis	1.19233818
50	MP0006276_abnormal_autonomic_nervous	1.18750848
51	MP0005387_immune_system_phenotype	1.15565311
52	MP0001790_abnormal_immune_system	1.15565311
53	MP0000490_abnormal_crypts_of	1.14334137
54	MP0008872_abnormal_physiological_respon	1.13835398
55	MP0002429_abnormal_blood_cell	1.12577430
56	MP0008995_early_reproductive_senescence	1.09855915
57	MP0002452_abnormal_antigen_presenting	1.04740103
58	MP0002822_catalepsy	1.02149518
59	MP0001661_extended_life_span	0.98108603
60	MP0006036_abnormal_mitochondrial_physio	0.97149300
61	MP0002089_abnormal_postnatal_growth/wei	0.94736698
62	MP0005551_abnormal_eye_electrophysiolog	0.94226466
63	MP0005646_abnormal_pituitary_gland	0.92445298
64	MP0000639_abnormal_adrenal_gland	0.91889905
65	MP0001764_abnormal_homeostasis	0.90036207
66	MP0009764_decreased_sensitivity_to	0.89220720
67	MP0005410_abnormal_fertilization	0.88338610
68	MP0008469_abnormal_protein_level	0.87055771
69	MP0009763_increased_sensitivity_to	0.84063257
70	MP0001765_abnormal_ion_homeostasis	0.82653853
71	MP0004510_myositis	0.81439980
72	MP0005166_decreased_susceptibility_to	0.81413525
73	MP0002019_abnormal_tumor_incidence	0.80837701
74	MP0004142_abnormal_muscle_tone	0.80827217
75	MP0000631_abnormal_neuroendocrine_gland	0.79495823
76	MP0001666_abnormal_nutrient_absorption	0.78848028
77	MP0002419_abnormal_innate_immunity	0.77352608
78	MP0008770_decreased_survivor_rate	0.77030742
79	MP0001919_abnormal_reproductive_system	0.77013350
80	MP0002136_abnormal_kidney_physiology	0.74625310
81	MP0001545_abnormal_hematopoietic_system	0.73286385
82	MP0005397_hematopoietic_system_phenotyp	0.73286385
83	MP0003943_abnormal_hepatobiliary_system	0.72173845
84	MP0001663_abnormal_digestive_system	0.70987163
85	MP0006072_abnormal_retinal_apoptosis	0.70696963
86	MP0000383_abnormal_hair_follicle	0.65247601
87	MP0003786_premature_aging	0.63475467
88	MP0009643_abnormal_urine_homeostasis	0.61567462
89	MP0001853_heart_inflammation	0.61150526
90	MP0002148_abnormal_hypersensitivity_rea	0.59916690
91	MP0001968_abnormal_touch/_nociception	0.58991491
92	MP0009046_muscle_twitch	0.58420350
93	MP0002009_preneoplasia	0.57374904
94	MP0002693_abnormal_pancreas_physiology	0.57011265
95	MP0005319_abnormal_enzyme/_coenzyme	0.56460258
96	MP0003938_abnormal_ear_development	0.54275183
97	MP0003436_decreased_susceptibility_to	0.53834020
98	MP0002736_abnormal_nociception_after	0.52343001
99	MP0003638_abnormal_response/metabolism_	0.51056880
100	MP0008775_abnormal_heart_ventricle	0.51039159

Predicted human phenotypes

Rank	Gene Set	Z-score
1	T lymphocytopenia (HP:0005403)	5.34484487
2	Increased IgM level (HP:0003496)	5.32823352
3	Abnormality of the heme biosynthetic pathway (HP:0010472)	5.25217816
4	B lymphocytopenia (HP:0010976)	5.02626371
5	Aplastic anemia (HP:0001915)	4.86801656
6	Poikilocytosis (HP:0004447)	4.78496376
7	Severe combined immunodeficiency (HP:0004430)	4.54141138
8	Abnormality of T cell number (HP:0011839)	4.48039182
9	Abnormality of B cell number (HP:0010975)	4.40155763
10	Hypochromic microcytic anemia (HP:0004840)	4.07758108
11	Gastrointestinal infarctions (HP:0005244)	4.03934893
12	IgG deficiency (HP:0004315)	4.01945160
13	Autoimmune hemolytic anemia (HP:0001890)	3.95981002
14	Abnormality of binocular vision (HP:0011514)	3.95774213
15	Diplopia (HP:0000651)	3.95774213
16	Hypoproteinemia (HP:0003075)	3.92338098
17	Combined immunodeficiency (HP:0005387)	3.86773165
18	Thyroiditis (HP:0100646)	3.82640693
19	Microcytic anemia (HP:0001935)	3.81414730
20	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.65628661
21	Reticulocytosis (HP:0001923)	3.56189765
22	Abnormality of macrophages (HP:0004311)	3.09680244
23	Encephalitis (HP:0002383)	3.02669036
24	Hyponatremia (HP:0002902)	2.97042636
25	Attenuation of retinal blood vessels (HP:0007843)	2.95592024
26	Abnormality of the prostate (HP:0008775)	2.94217182
27	Hypoplasia of the thymus (HP:0000778)	2.93693146
28	Hypoplasia of the uterus (HP:0000013)	2.85379638
29	Ureteral obstruction (HP:0006000)	2.82584895
30	Decreased central vision (HP:0007663)	2.82187721
31	Elevated erythrocyte sedimentation rate (HP:0003565)	2.77040291
32	Chronic diarrhea (HP:0002028)	2.70656078
33	Abnormality of reticulocytes (HP:0004312)	2.70386039
34	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.69029270
35	Ureteral stenosis (HP:0000071)	2.61692770
36	Obstructive lung disease (HP:0006536)	2.57127734
37	Chronic obstructive pulmonary disease (HP:0006510)	2.57127734
38	Constricted visual fields (HP:0001133)	2.51943910
39	Erythema (HP:0010783)	2.50509315
40	Agammaglobulinemia (HP:0004432)	2.47188921
41	Abnormality of sodium homeostasis (HP:0010931)	2.43211894
42	Abnormal number of erythroid precursors (HP:0012131)	2.42822411
43	Chronic mucocutaneous candidiasis (HP:0002728)	2.42558870
44	Recurrent cutaneous fungal infections (HP:0011370)	2.42558870
45	Abnormality of cells of the erythroid lineage (HP:0012130)	2.41743059
46	Increased corneal curvature (HP:0100692)	2.40033946
47	Keratoconus (HP:0000563)	2.40033946
48	Meningitis (HP:0001287)	2.39562571
49	Skin rash (HP:0000988)	2.37601466
50	Pancytopenia (HP:0001876)	2.33916285
51	Abnormality of T cells (HP:0002843)	2.32389638
52	Renal Fanconi syndrome (HP:0001994)	2.31727843
53	Severe visual impairment (HP:0001141)	2.31221778
54	Abnormal rod and cone electroretinograms (HP:0008323)	2.30145383
55	Lymphopenia (HP:0001888)	2.29549293
56	Abnormality of eosinophils (HP:0001879)	2.25529011
57	Brushfield spots (HP:0001088)	2.19770160
58	Pendular nystagmus (HP:0012043)	2.14829604
59	Acute hepatic failure (HP:0006554)	2.14761031
60	Pustule (HP:0200039)	2.11724495
61	Hypergammaglobulinemia (HP:0010702)	2.11112438
62	Tongue fasciculations (HP:0001308)	2.10884887
63	Gonadal dysgenesis (HP:0000133)	2.09886985
64	Recurrent otitis media (HP:0000403)	2.09348142
65	Radial bowing (HP:0002986)	2.08305843
66	Hypochromic anemia (HP:0001931)	2.07965393
67	Neoplasm of head and neck (HP:0012288)	2.07762402
68	Esophageal neoplasm (HP:0100751)	2.07762402
69	Pulmonary infiltrates (HP:0002113)	2.04508118
70	Acanthocytosis (HP:0001927)	2.04385524
71	Female pseudohermaphroditism (HP:0010458)	2.00410140
72	Lymphoma (HP:0002665)	2.00141387
73	Chest pain (HP:0100749)	1.98759421
74	Abnormality of male internal genitalia (HP:0000022)	1.97206217
75	Aortic dissection (HP:0002647)	1.95970676
76	Recurrent bronchitis (HP:0002837)	1.95446318
77	Increased serum ferritin (HP:0003281)	1.93108390
78	Cholelithiasis (HP:0001081)	1.92807664
79	Abnormality of the fingertips (HP:0001211)	1.92467749
80	Bronchitis (HP:0012387)	1.91736433
81	Abnormality of cells of the lymphoid lineage (HP:0012140)	1.91663494
82	Muscle fibrillation (HP:0010546)	1.89674553
83	Pallor (HP:0000980)	1.87470260
84	Leukocytosis (HP:0001974)	1.86515109
85	Chronic bronchitis (HP:0004469)	1.86340236
86	Abnormality of iron homeostasis (HP:0011031)	1.86160375
87	Abolished electroretinogram (ERG) (HP:0000550)	1.85955576
88	Glomerulopathy (HP:0100820)	1.85776504
89	Dyschromatopsia (HP:0007641)	1.83660681
90	Bowing of the arm (HP:0006488)	1.83023562
91	Bowed forearm bones (HP:0003956)	1.83023562
92	Paralysis (HP:0003470)	1.81726992
93	Mediastinal lymphadenopathy (HP:0100721)	1.81478087
94	Interstitial pulmonary disease (HP:0006530)	1.81327940
95	Polyneuropathy (HP:0001271)	1.80491843
96	Gangrene (HP:0100758)	1.79752890
97	Male infertility (HP:0003251)	1.78180863
98	Epistaxis (HP:0000421)	1.76462016
99	Pigmentary retinal degeneration (HP:0001146)	1.76145441
100	Cerebral palsy (HP:0100021)	1.75560431

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ZAK	6.59216355
2	TLK1	6.05391437
3	TESK2	5.72318474
4	KDR	4.93765400
5	TXK	2.88670681
6	VRK1	2.80772001
7	TNK2	2.57199313
8	TESK1	2.57125878
9	MAP3K11	2.24029664
10	TAOK3	2.09422257
11	CDK8	1.82675307
12	RPS6KA4	1.79679686
13	LIMK1	1.78141169
14	TEC	1.76530058
15	MAP4K1	1.72280836
16	ZAP70	1.71220695
17	PIM1	1.66382735
18	GRK6	1.47440050
19	ITK	1.43412671
20	IKBKE	1.42725223
21	SYK	1.30642024
22	MST4	1.22402723
23	ADRBK2	1.22084500
24	TRPM7	1.19706273
25	GRK7	1.19017637
26	PASK	1.18842240
27	PRKD3	1.17478471
28	MAP2K6	1.16182700
29	NEK9	1.13166767
30	RPS6KA5	1.09374063
31	EIF2AK1	1.07870391
32	BCKDK	0.91249796
33	BTK	0.88804870
34	PRKCH	0.87672854
35	CDK4	0.86608779
36	STK16	0.84712550
37	DYRK1B	0.84209573
38	PRKCQ	0.81880837
39	MAP3K5	0.78409048
40	TAOK2	0.76778521
41	NME1	0.76221466
42	TYRO3	0.75958427
43	PKN1	0.70316209
44	JAK2	0.69285293
45	LYN	0.68803362
46	LCK	0.67839236
47	MAP2K1	0.63800864
48	PAK1	0.62405033
49	CSF1R	0.61038925
50	BMPR1B	0.61001553
51	PRKD2	0.59391028
52	GRK1	0.57526957
53	ROCK1	0.53911749
54	MAP3K1	0.51478779
55	AURKA	0.51343398
56	CAMKK2	0.51170855
57	CSK	0.50930074
58	LRRK2	0.50878861
59	TBK1	0.50178584
60	FES	0.50037529
61	FYN	0.48571836
62	HIPK2	0.46041651
63	MAPK11	0.44869883
64	ERN1	0.42561840
65	BMX	0.40276964
66	TAOK1	0.39491274
67	TNIK	0.39324224
68	PRKCA	0.38645887
69	PLK1	0.37715511
70	DYRK3	0.32706071
71	FRK	0.31672021
72	VRK2	0.31552319
73	CAMKK1	0.31512699
74	SCYL2	0.31467541
75	MAP2K7	0.28704192
76	MARK3	0.27827628
77	PRKAA2	0.27390171
78	WNK1	0.27138200
79	IKBKB	0.25711654
80	LMTK2	0.24665172
81	PLK3	0.24358821
82	INSR	0.23547045
83	PRKACA	0.23483407
84	PRKCD	0.22746208
85	INSRR	0.22294795
86	AKT2	0.22061129
87	ERBB2	0.20690192
88	CSNK2A1	0.20153134
89	PDGFRB	0.19470612
90	PRKCB	0.18823613
91	ABL1	0.15174698
92	CSNK1G3	0.14969803
93	RPS6KA6	0.14828859
94	ERBB3	0.14528765
95	OBSCN	0.13891723
96	TRIM28	0.13646896
97	MYLK	0.13380766
98	PRKAA1	0.13363102
99	PIM2	0.13284387
100	RPS6KC1	0.12965296

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Primary immunodeficiency_Homo sapiens_hsa05340	6.47095796
2	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	3.87952850
3	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	3.52344551
4	Proteasome_Homo sapiens_hsa03050	3.50042884
5	Malaria_Homo sapiens_hsa05144	3.47052328
6	T cell receptor signaling pathway_Homo sapiens_hsa04660	3.38848796
7	Hematopoietic cell lineage_Homo sapiens_hsa04640	3.25794940
8	RNA polymerase_Homo sapiens_hsa03020	2.95832833
9	Oxidative phosphorylation_Homo sapiens_hsa00190	2.89272841
10	Nitrogen metabolism_Homo sapiens_hsa00910	2.43934374
11	Antigen processing and presentation_Homo sapiens_hsa04612	2.41521945
12	Parkinsons disease_Homo sapiens_hsa05012	2.12017610
13	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	2.11706932
14	Graft-versus-host disease_Homo sapiens_hsa05332	1.92303241
15	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.68822705
16	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.58231838
17	Shigellosis_Homo sapiens_hsa05131	1.56395733
18	Measles_Homo sapiens_hsa05162	1.51286293
19	Collecting duct acid secretion_Homo sapiens_hsa04966	1.44193996
20	Alzheimers disease_Homo sapiens_hsa05010	1.33048816
21	Ribosome_Homo sapiens_hsa03010	1.31077951
22	Linoleic acid metabolism_Homo sapiens_hsa00591	1.27601644
23	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.27184243
24	One carbon pool by folate_Homo sapiens_hsa00670	1.25570721
25	Allograft rejection_Homo sapiens_hsa05330	1.21263018
26	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.21158403
27	Ether lipid metabolism_Homo sapiens_hsa00565	1.18699143
28	Huntingtons disease_Homo sapiens_hsa05016	1.17433077
29	Cardiac muscle contraction_Homo sapiens_hsa04260	1.12512211
30	Olfactory transduction_Homo sapiens_hsa04740	1.12401851
31	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	1.10444198
32	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	1.07619987
33	Phototransduction_Homo sapiens_hsa04744	1.03240271
34	Homologous recombination_Homo sapiens_hsa03440	1.02340562
35	DNA replication_Homo sapiens_hsa03030	1.01902858
36	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	1.01630528
37	Regulation of autophagy_Homo sapiens_hsa04140	0.97349019
38	Salmonella infection_Homo sapiens_hsa05132	0.94287483
39	Type I diabetes mellitus_Homo sapiens_hsa04940	0.91200018
40	Pyrimidine metabolism_Homo sapiens_hsa00240	0.82269127
41	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.81253703
42	ABC transporters_Homo sapiens_hsa02010	0.79776116
43	Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142	0.79432613
44	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.72722317
45	Sphingolipid metabolism_Homo sapiens_hsa00600	0.72681499
46	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.72204068
47	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.71717176
48	Purine metabolism_Homo sapiens_hsa00230	0.71335506
49	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.69900767
50	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.68764247
51	Mineral absorption_Homo sapiens_hsa04978	0.62681012
52	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.61714413
53	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.61652900
54	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	0.61066540
55	Endocytosis_Homo sapiens_hsa04144	0.60617930
56	Taste transduction_Homo sapiens_hsa04742	0.59935025
57	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.58683719
58	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.56271716
59	African trypanosomiasis_Homo sapiens_hsa05143	0.55084062
60	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.54119429
61	Peroxisome_Homo sapiens_hsa04146	0.54110117
62	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.52552929
63	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.52466191
64	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.52342920
65	Caffeine metabolism_Homo sapiens_hsa00232	0.52328007
66	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.52261646
67	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.52107457
68	Rheumatoid arthritis_Homo sapiens_hsa05323	0.50359967
69	Viral myocarditis_Homo sapiens_hsa05416	0.48277398
70	Mismatch repair_Homo sapiens_hsa03430	0.48218905
71	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.45723986
72	Alcoholism_Homo sapiens_hsa05034	0.44573322
73	Glycerolipid metabolism_Homo sapiens_hsa00561	0.43385698
74	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.40051218
75	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.35046783
76	HTLV-I infection_Homo sapiens_hsa05166	0.32845238
77	Vibrio cholerae infection_Homo sapiens_hsa05110	0.32362925
78	Fanconi anemia pathway_Homo sapiens_hsa03460	0.31648741
79	Fat digestion and absorption_Homo sapiens_hsa04975	0.28214133
80	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.26858588
81	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.26678675
82	TNF signaling pathway_Homo sapiens_hsa04668	0.25478388
83	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.22668109
84	Metabolic pathways_Homo sapiens_hsa01100	0.22238528
85	Osteoclast differentiation_Homo sapiens_hsa04380	0.22184774
86	Platelet activation_Homo sapiens_hsa04611	0.21642389
87	Apoptosis_Homo sapiens_hsa04210	0.20738200
88	Butanoate metabolism_Homo sapiens_hsa00650	0.18062101
89	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.17592597
90	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.17301075
91	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.16806436
92	Amphetamine addiction_Homo sapiens_hsa05031	0.16619267
93	Ras signaling pathway_Homo sapiens_hsa04014	0.15862726
94	Pancreatic cancer_Homo sapiens_hsa05212	0.15721060
95	MAPK signaling pathway_Homo sapiens_hsa04010	0.15297459
96	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.13071050
97	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.13011366
98	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.12394206
99	Pertussis_Homo sapiens_hsa05133	0.10695938
100	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.10156196

TRBV20OR9-2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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