TRBV21-1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1activated T cell proliferation (GO:0050798)7.36758096
2intra-S DNA damage checkpoint (GO:0031573)7.29860138
3mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)7.14959593
4positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021107.14959593
5regulation of transforming growth factor beta2 production (GO:0032909)6.74239608
6cellular response to interleukin-15 (GO:0071350)6.64506322
7macrophage differentiation (GO:0030225)5.86379748
8spliceosomal tri-snRNP complex assembly (GO:0000244)5.82766442
9pyrimidine ribonucleoside catabolic process (GO:0046133)5.67824494
10cytidine metabolic process (GO:0046087)5.62613414
11cytidine catabolic process (GO:0006216)5.62613414
12cytidine deamination (GO:0009972)5.62613414
13response to interleukin-15 (GO:0070672)5.62034475
14G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)5.61223221
15regulation of RIG-I signaling pathway (GO:0039535)5.54956260
16necroptotic process (GO:0070266)5.44161471
17positive regulation of mitochondrial membrane permeability (GO:0035794)5.27528817
18positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)5.22128355
19positive regulation of natural killer cell mediated immunity (GO:0002717)5.16442360
20negative regulation of viral genome replication (GO:0045071)5.08025129
21regulation of T cell tolerance induction (GO:0002664)5.05838782
22programmed necrotic cell death (GO:0097300)4.92958609
23regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)4.88387727
24regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.75290921
25positive regulation of mRNA catabolic process (GO:0061014)4.72701965
26regulation of natural killer cell mediated cytotoxicity (GO:0042269)4.69194200
27regulation of natural killer cell mediated immunity (GO:0002715)4.69194200
28positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.68555516
29necrotic cell death (GO:0070265)4.65290390
30negative T cell selection (GO:0043383)4.62906074
31T cell apoptotic process (GO:0070231)4.61211648
32positive regulation of transforming growth factor beta production (GO:0071636)4.59384336
33UDP-N-acetylglucosamine metabolic process (GO:0006047)4.52885933
34antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.43538032
35regulation of regulatory T cell differentiation (GO:0045589)4.38627630
36cellular response to arsenic-containing substance (GO:0071243)4.31462574
37positive regulation of tolerance induction (GO:0002645)4.30287778
38positive regulation of interferon-alpha production (GO:0032727)4.26648614
39negative thymic T cell selection (GO:0045060)4.18680170
40positive regulation of macrophage differentiation (GO:0045651)4.16320705
41positive regulation of leukocyte mediated cytotoxicity (GO:0001912)4.16039319
42regulation of interferon-alpha production (GO:0032647)4.15839805
43positive T cell selection (GO:0043368)4.13992183
44regulation of tolerance induction (GO:0002643)4.13484300
45positive regulation of interferon-beta production (GO:0032728)4.12452055
46regulation of mRNA catabolic process (GO:0061013)4.11022975
47negative regulation by host of viral transcription (GO:0043922)4.02827555
48T cell costimulation (GO:0031295)4.01223463
49lymphocyte apoptotic process (GO:0070227)3.99780127
50nucleotide-sugar biosynthetic process (GO:0009226)3.99534500
51lymphocyte costimulation (GO:0031294)3.95640183
52positive thymic T cell selection (GO:0045059)3.91651170
53regulation of viral genome replication (GO:0045069)3.91162977
54tolerance induction (GO:0002507)3.86008370
55T cell migration (GO:0072678)3.84033977
56regulation of leukocyte mediated cytotoxicity (GO:0001910)3.82856601
57thymic T cell selection (GO:0045061)3.78925293
58positive regulation of gamma-delta T cell activation (GO:0046645)3.77703763
59purinergic nucleotide receptor signaling pathway (GO:0035590)3.77634107
60positive regulation of translational initiation (GO:0045948)3.76180612
61positive regulation of cell killing (GO:0031343)3.70737706
62response to interferon-beta (GO:0035456)3.68916813
63regulation of alpha-beta T cell proliferation (GO:0046640)3.66224572
64regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902108)3.64316541
65positive regulation of calcium-mediated signaling (GO:0050850)3.60797299
66G-protein coupled purinergic receptor signaling pathway (GO:0035588)3.53796333
67negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.52550420
68negative regulation of cell killing (GO:0031342)3.52550420
69regulation of interferon-beta production (GO:0032648)3.49380746
70regulation of cell killing (GO:0031341)3.47150985
71T cell selection (GO:0045058)3.45059847
72antigen processing and presentation via MHC class Ib (GO:0002475)3.44481443
73regulation of chronic inflammatory response (GO:0002676)3.43070229
74antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.41768664
75ribosome assembly (GO:0042255)3.38826854
76DNA deamination (GO:0045006)3.35502917
77antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.33100689
78positive regulation of alpha-beta T cell proliferation (GO:0046641)3.31544556
79negative regulation of viral process (GO:0048525)3.30203277
80regulation of necroptotic process (GO:0060544)3.29293330
81T cell receptor signaling pathway (GO:0050852)3.28766424
82positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.25879981
83regulation of B cell receptor signaling pathway (GO:0050855)3.20363917
84protein localization to cell surface (GO:0034394)3.19294685
85leukocyte apoptotic process (GO:0071887)3.19104409
86regulation of T cell receptor signaling pathway (GO:0050856)3.14787036
87nucleotide-sugar metabolic process (GO:0009225)3.10180308
88antigen processing and presentation of endogenous antigen (GO:0019883)3.09837053
89regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.01773789
90regulation of gamma-delta T cell differentiation (GO:0045586)3.00625772
91regulation of activation of Janus kinase activity (GO:0010533)2.99943911
92antigen receptor-mediated signaling pathway (GO:0050851)2.98346946
93positive regulation of T cell mediated cytotoxicity (GO:0001916)2.97297800
94regulation of T cell mediated cytotoxicity (GO:0001914)2.94196115
95gonadal mesoderm development (GO:0007506)2.93970675
96cellular response to type I interferon (GO:0071357)2.93252833
97type I interferon signaling pathway (GO:0060337)2.93252833
98regulation of interleukin-2 biosynthetic process (GO:0045076)2.89125850
99response to type I interferon (GO:0034340)2.89123183
100positive regulation of lymphocyte mediated immunity (GO:0002708)2.86694261

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human7.60646221
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse6.05328048
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.80082665
4IRF8_22096565_ChIP-ChIP_GC-B_Human5.46045416
5GATA1_22025678_ChIP-Seq_K562_Human5.11013845
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.89869216
7SMAD_19615063_ChIP-ChIP_OVARY_Human3.63360019
8CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.43917903
9IRF8_21731497_ChIP-ChIP_J774_Mouse3.38720115
10RUNX_20019798_ChIP-Seq_JUKART_Human3.22286142
11MYB_26560356_Chip-Seq_TH2_Human3.19427317
12STAT4_19710469_ChIP-ChIP_TH1__Mouse3.18226841
13IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.04643279
14FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.01583565
15E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.88678915
16STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.76181827
17BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.65625320
18MYB_26560356_Chip-Seq_TH1_Human2.55540879
19MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.34370652
20SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.19051685
21GATA3_27048872_Chip-Seq_THYMUS_Human1.90510915
22UTX_26944678_Chip-Seq_JUKART_Human1.83084313
23MAF_26560356_Chip-Seq_TH1_Human1.81091675
24E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.79761034
25GATA3_26560356_Chip-Seq_TH2_Human1.74975805
26MAF_26560356_Chip-Seq_TH2_Human1.72457485
27SPI1_23547873_ChIP-Seq_NB4_Human1.72004151
28IRF8_27001747_Chip-Seq_BMDM_Mouse1.67604817
29RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.67074210
30ELF1_17652178_ChIP-ChIP_JURKAT_Human1.61431042
31FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.59658097
32LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.57135121
33VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.46542833
34VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.46225227
35MYB_21317192_ChIP-Seq_ERMYB_Mouse1.39344412
36LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.38550502
37GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.37547654
38SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.37362510
39VDR_23849224_ChIP-Seq_CD4+_Human1.28392206
40PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.27476484
41CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.24833476
42SMRT_27268052_Chip-Seq_Bcells_Human1.19942501
43PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.19100697
44FLI1_27457419_Chip-Seq_LIVER_Mouse1.16144220
45NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.14312015
46RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.09184344
47FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.06740130
48MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.03438357
49MYC_22102868_ChIP-Seq_BL_Human1.01499180
50PCGF2_27294783_Chip-Seq_NPCs_Mouse1.00379133
51GATA1_19941826_ChIP-Seq_K562_Human0.98918056
52BRD4_27068464_Chip-Seq_AML-cells_Mouse0.98329764
53GBX2_23144817_ChIP-Seq_PC3_Human0.96937346
54CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.96789117
55NFE2_27457419_Chip-Seq_LIVER_Mouse0.95974428
56CEBPB_22108803_ChIP-Seq_LS180_Human0.92773801
57IGF1R_20145208_ChIP-Seq_DFB_Human0.91465328
58SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.89115224
59SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.88496157
60EZH2_27294783_Chip-Seq_NPCs_Mouse0.88021167
61SUZ12_27294783_Chip-Seq_NPCs_Mouse0.87024591
62GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.86765638
63EGR1_23403033_ChIP-Seq_LIVER_Mouse0.85809497
64GATA3_26560356_Chip-Seq_TH1_Human0.84232757
65RUNX1_22412390_ChIP-Seq_EML_Mouse0.83630842
66GATA1_19941827_ChIP-Seq_MEL_Mouse0.82664361
67VDR_24763502_ChIP-Seq_THP-1_Human0.81793561
68VDR_22108803_ChIP-Seq_LS180_Human0.80904665
69TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.80014457
70TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.79149229
71SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79126059
72NOTCH1_21737748_ChIP-Seq_TLL_Human0.78400800
73VDR_24787735_ChIP-Seq_THP-1_Human0.77443960
74TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.77290494
75CRX_20693478_ChIP-Seq_RETINA_Mouse0.76607924
76NANOG_20526341_ChIP-Seq_ESCs_Human0.74792409
77SPI1_23127762_ChIP-Seq_K562_Human0.73945037
78RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.72688551
79GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.69763862
80RUNX1_27457419_Chip-Seq_LIVER_Mouse0.68863587
81OCT4_21477851_ChIP-Seq_ESCs_Mouse0.68719108
82OCT4_18555785_Chip-Seq_ESCs_Mouse0.68198397
83BCL6_27268052_Chip-Seq_Bcells_Human0.67345486
84FOXP3_21729870_ChIP-Seq_TREG_Human0.67032193
85CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.66871099
86SMAD1_18555785_Chip-Seq_ESCs_Mouse0.65758870
87GATA2_21666600_ChIP-Seq_HMVEC_Human0.64655556
88SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.64650513
89RAC3_21632823_ChIP-Seq_H3396_Human0.64437485
90PU1_27457419_Chip-Seq_LIVER_Mouse0.62840546
91EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.62735665
92SRY_22984422_ChIP-ChIP_TESTIS_Rat0.62689444
93PCGF2_27294783_Chip-Seq_ESCs_Mouse0.62298607
94WDR5_24793694_ChIP-Seq_LNCAP_Human0.62039141
95FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.61806431
96EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.61688501
97RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.61655248
98STAT1_20625510_ChIP-Seq_HELA_Human0.61053958
99RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.60987250
100NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.60878988

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology5.25701968
2MP0005671_abnormal_response_to5.11101023
3MP0005451_abnormal_body_composition4.18094794
4MP0009785_altered_susceptibility_to3.86229833
5MP0001835_abnormal_antigen_presentation3.65698028
6MP0001800_abnormal_humoral_immune3.06585104
7MP0002638_abnormal_pupillary_reflex3.04045525
8MP0002723_abnormal_immune_serum2.96091703
9MP0001873_stomach_inflammation2.92125958
10MP0005025_abnormal_response_to2.82688946
11MP0005076_abnormal_cell_differentiation2.72220367
12MP0002148_abnormal_hypersensitivity_rea2.64639704
13MP0005000_abnormal_immune_tolerance2.62673438
14MP0009333_abnormal_splenocyte_physiolog2.62202961
15MP0002420_abnormal_adaptive_immunity2.61903695
16MP0001819_abnormal_immune_cell2.56204270
17MP0010155_abnormal_intestine_physiology2.52498859
18MP0001851_eye_inflammation2.46813104
19MP0006082_CNS_inflammation2.38910131
20MP0003436_decreased_susceptibility_to2.37134188
21MP0001790_abnormal_immune_system2.34716447
22MP0005387_immune_system_phenotype2.34716447
23MP0002398_abnormal_bone_marrow2.34602361
24MP0002452_abnormal_antigen_presenting2.32880068
25MP0003866_abnormal_defecation2.19088066
26MP0000716_abnormal_immune_system2.04981054
27MP0000372_irregular_coat_pigmentation1.92373942
28MP0002166_altered_tumor_susceptibility1.83428061
29MP0002419_abnormal_innate_immunity1.82789581
30MP0000858_altered_metastatic_potential1.81940083
31MP0000703_abnormal_thymus_morphology1.80464680
32MP0005310_abnormal_salivary_gland1.79891316
33MP0000685_abnormal_immune_system1.76684535
34MP0003693_abnormal_embryo_hatching1.75250038
35MP0001845_abnormal_inflammatory_respons1.71553016
36MP0000689_abnormal_spleen_morphology1.69234012
37MP0002405_respiratory_system_inflammati1.68736648
38MP0002722_abnormal_immune_system1.64088877
39MP0009115_abnormal_fat_cell1.61388216
40MP0002429_abnormal_blood_cell1.60175546
41MP0002277_abnormal_respiratory_mucosa1.56573680
42MP0008469_abnormal_protein_level1.43210147
43MP0010386_abnormal_urinary_bladder1.43040513
44MP0002006_tumorigenesis1.42457957
45MP0002933_joint_inflammation1.39589428
46MP0008569_lethality_at_weaning1.28736740
47MP0003724_increased_susceptibility_to1.25578707
48MP0001533_abnormal_skeleton_physiology1.24903236
49MP0009765_abnormal_xenobiotic_induced1.22406886
50MP0002163_abnormal_gland_morphology1.15509225
51MP0009763_increased_sensitivity_to1.15019730
52MP0001853_heart_inflammation1.07411086
53MP0001919_abnormal_reproductive_system1.06039287
54MP0005408_hypopigmentation1.03351206
55MP0003045_fibrosis1.02915633
56MP0004134_abnormal_chest_morphology1.02636296
57MP0004130_abnormal_muscle_cell0.99542608
58MP0003786_premature_aging0.98323781
59MP0000427_abnormal_hair_cycle0.95444213
60MP0005464_abnormal_platelet_physiology0.91556466
61MP0004381_abnormal_hair_follicle0.90715834
62MP0000343_altered_response_to0.87744489
63MP0001764_abnormal_homeostasis0.84755331
64MP0002254_reproductive_system_inflammat0.83363680
65MP0004947_skin_inflammation0.82858063
66MP0003303_peritoneal_inflammation0.81398903
67MP0001727_abnormal_embryo_implantation0.81040541
68MP0001666_abnormal_nutrient_absorption0.79913753
69MP0001502_abnormal_circadian_rhythm0.79000640
70MP0001663_abnormal_digestive_system0.78129614
71MP0002693_abnormal_pancreas_physiology0.77426743
72MP0001191_abnormal_skin_condition0.76274313
73MP0000490_abnormal_crypts_of0.75614920
74MP0002019_abnormal_tumor_incidence0.74148058
75MP0009764_decreased_sensitivity_to0.69014324
76MP0002876_abnormal_thyroid_physiology0.65937020
77MP0001270_distended_abdomen0.62082463
78MP0003300_gastrointestinal_ulcer0.61465984
79MP0002970_abnormal_white_adipose0.54765761
80MP0001243_abnormal_dermal_layer0.52487797
81MP0002168_other_aberrant_phenotype0.52431949
82MP0005389_reproductive_system_phenotype0.51776233
83MP0003448_altered_tumor_morphology0.50126710
84MP0000367_abnormal_coat/_hair0.47925204
85MP0005166_decreased_susceptibility_to0.47646409
86MP0008872_abnormal_physiological_respon0.47216058
87MP0005075_abnormal_melanosome_morpholog0.45725666
88MP0004885_abnormal_endolymph0.43445550
89MP0005666_abnormal_adipose_tissue0.43285991
90MP0005390_skeleton_phenotype0.42060906
91MP0009643_abnormal_urine_homeostasis0.41652082
92MP0001348_abnormal_lacrimal_gland0.41550791
93MP0010307_abnormal_tumor_latency0.40872552
94MP0003943_abnormal_hepatobiliary_system0.40018440
95MP0005379_endocrine/exocrine_gland_phen0.39633454
96MP0004742_abnormal_vestibular_system0.38700856
97MP0001963_abnormal_hearing_physiology0.38077853
98MP0000465_gastrointestinal_hemorrhage0.38077270
99MP0001765_abnormal_ion_homeostasis0.37776074
100MP0000609_abnormal_liver_physiology0.37645511

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)7.33506711
2Abnormality of T cell number (HP:0011839)7.27517367
3Stomatitis (HP:0010280)5.93480161
4Increased IgM level (HP:0003496)5.28529216
5IgG deficiency (HP:0004315)5.02785381
6Retrobulbar optic neuritis (HP:0100654)4.81661981
7Optic neuritis (HP:0100653)4.81661981
8Chronic diarrhea (HP:0002028)4.62120328
9Abnormality of T cells (HP:0002843)4.54788281
10Orchitis (HP:0100796)4.32547640
11Joint swelling (HP:0001386)4.16837020
12Recurrent cutaneous fungal infections (HP:0011370)4.10640856
13Chronic mucocutaneous candidiasis (HP:0002728)4.10640856
14Autoimmune hemolytic anemia (HP:0001890)4.07366759
15Hypoproteinemia (HP:0003075)4.07014466
16Myositis (HP:0100614)4.03768458
17Severe combined immunodeficiency (HP:0004430)4.01305115
18IgA deficiency (HP:0002720)3.85285786
19Pulmonary infiltrates (HP:0002113)3.75291342
20Recurrent fungal infections (HP:0002841)3.72191637
21Vasculitis (HP:0002633)3.69126500
22Abnormal delayed hypersensitivity skin test (HP:0002963)3.66730257
23Agammaglobulinemia (HP:0004432)3.59347991
24Recurrent bronchitis (HP:0002837)3.37870073
25Abnormality of eosinophils (HP:0001879)3.37466078
26Progressive inability to walk (HP:0002505)3.29033230
27Hemoptysis (HP:0002105)3.25968573
28Meningitis (HP:0001287)3.24279078
29Polyneuropathy (HP:0001271)3.19116733
30Keratoconjunctivitis sicca (HP:0001097)3.18567023
31IgM deficiency (HP:0002850)3.13919430
32Keratoconjunctivitis (HP:0001096)3.12265327
33Enlarged epiphyses (HP:0010580)3.08411021
34Recurrent viral infections (HP:0004429)3.06327021
35Combined immunodeficiency (HP:0005387)3.03875640
36Encephalitis (HP:0002383)2.97592109
37Thyroiditis (HP:0100646)2.96412740
38Hypoplasia of the thymus (HP:0000778)2.90953110
39Abnormality of cells of the lymphoid lineage (HP:0012140)2.90875333
40Abnormality of the pleura (HP:0002103)2.89481182
41Gangrene (HP:0100758)2.84839453
42Lymphopenia (HP:0001888)2.81012744
43Elevated erythrocyte sedimentation rate (HP:0003565)2.80686532
44Hypochromic anemia (HP:0001931)2.75620651
45Granulocytopenia (HP:0001913)2.75210039
46Leukocytosis (HP:0001974)2.67971738
47Pulmonary embolism (HP:0002204)2.64525380
48Anorexia (HP:0002039)2.61671796
49Metaphyseal dysplasia (HP:0100255)2.61438108
50Keratitis (HP:0000491)2.60611167
51Eosinophilia (HP:0001880)2.57145356
52Abnormality of the prostate (HP:0008775)2.53029515
53Abnormality of T cell physiology (HP:0011840)2.50357471
54Autoimmune thrombocytopenia (HP:0001973)2.49064187
553-Methylglutaconic aciduria (HP:0003535)2.39707501
56Premature ovarian failure (HP:0008209)2.38224744
57Ureteral stenosis (HP:0000071)2.34033832
58Arterial thrombosis (HP:0004420)2.28773048
59Pustule (HP:0200039)2.27943812
60Ureteral obstruction (HP:0006000)2.24775945
61Renal cortical cysts (HP:0000803)2.22894262
62Chronic obstructive pulmonary disease (HP:0006510)2.22466946
63Obstructive lung disease (HP:0006536)2.22466946
64Gastrointestinal infarctions (HP:0005244)2.17728986
65Episodic fever (HP:0001954)2.17656622
66Porencephaly (HP:0002132)2.17068007
67Recurrent skin infections (HP:0001581)2.11074214
68Abnormality of the pericardium (HP:0001697)2.08805368
69Hypergammaglobulinemia (HP:0010702)2.07831426
70Prominent nose (HP:0000448)2.07291314
71Glomerulopathy (HP:0100820)2.06147876
72Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.06106608
73Exotropia (HP:0000577)2.04853014
74Arthropathy (HP:0003040)2.03348497
75Bronchitis (HP:0012387)2.03293864
76Mediastinal lymphadenopathy (HP:0100721)2.02685511
77Eczematoid dermatitis (HP:0000976)1.99697812
78Cerebral hypomyelination (HP:0006808)1.99632919
79Lymphoma (HP:0002665)1.97591620
80Degeneration of the lateral corticospinal tracts (HP:0002314)1.97083122
81Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.97083122
82Abnormality of dental color (HP:0011073)1.92927703
83Clubbing of toes (HP:0100760)1.92303561
84Skin rash (HP:0000988)1.88199863
85Chest pain (HP:0100749)1.85720206
86Gastrointestinal stroma tumor (HP:0100723)1.83202651
87Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.78749952
88Glucose intolerance (HP:0000833)1.77307614
89Brushfield spots (HP:0001088)1.76697125
90Hepatosplenomegaly (HP:0001433)1.76226646
91Panhypogammaglobulinemia (HP:0003139)1.73376043
92Abnormal spermatogenesis (HP:0008669)1.70002680
93Squamous cell carcinoma (HP:0002860)1.69191675
94Neutropenia (HP:0001875)1.67618717
95Epistaxis (HP:0000421)1.67457505
96Paralysis (HP:0003470)1.63306976
97Urticaria (HP:0001025)1.62828678
98Abnormality of macrophages (HP:0004311)1.61367756
99Restrictive lung disease (HP:0002091)1.60458300
100Arterial tortuosity (HP:0005116)1.59879067

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK17.88846856
2TXK6.26943398
3VRK14.96832271
4PRPF4B3.41804213
5FES2.98839613
6PIK3CA2.84170493
7TYRO32.75950352
8IRAK32.33081090
9TAOK32.12058978
10CSK1.91870700
11MAP4K11.82955997
12TGFBR21.72383041
13ITK1.64568333
14BTK1.64283017
15SIK31.57559856
16MAP2K61.52369591
17TNIK1.43129908
18TRPM71.42997278
19CDK81.41347418
20NLK1.34848216
21JAK11.32317728
22FGFR41.30434403
23BMPR21.23961875
24LCK1.23029205
25MATK1.21632871
26TYK21.21155974
27MAPK111.16140624
28IKBKE1.15019458
29TEC1.10745902
30PLK31.09297586
31BCR1.09028606
32JAK31.07978921
33PRKCQ1.07619152
34HCK1.06354740
35TRIM281.03930898
36NTRK11.00422471
37PIM10.98084101
38TBK10.95997285
39CAMKK10.95500100
40MAP3K140.92359779
41PDGFRB0.92287917
42TLK10.91388383
43ADRBK20.91272632
44CAMKK20.90344625
45ACVR1B0.88308407
46SYK0.85935516
47LYN0.83154354
48RIPK40.77743333
49MELK0.76909521
50GRK60.75069475
51MAP4K20.74285037
52STK100.73916315
53JAK20.70926629
54IKBKB0.70840348
55PDK10.70754714
56TRIB30.69805769
57PRKCE0.68871926
58KDR0.68612518
59MARK30.67726758
60PKN20.66915910
61RET0.65049728
62KIT0.61801889
63MAPK70.57303487
64PDPK10.56998865
65PASK0.56938951
66CDK30.56410570
67FGFR30.55267319
68ZAP700.53002848
69LRRK20.46184290
70FYN0.42192715
71GRK70.42093447
72HIPK20.40256625
73CLK10.40078317
74PHKG20.37503609
75PHKG10.37503609
76IRAK40.36469693
77MAPKAPK20.34830597
78ZAK0.34485717
79BRD40.31338975
80MAPK130.31107633
81CHUK0.30543123
82IGF1R0.29904496
83MAP3K110.29090369
84NUAK10.28495827
85STK110.26105064
86BLK0.26038550
87IRAK10.25381355
88INSR0.22332260
89DYRK1A0.21228163
90EPHA30.19352044
91BMX0.17726340
92TNK20.17468680
93PRKACG0.17237544
94MAPK120.17148762
95MAPK30.15052438
96BUB10.14733496
97NME10.14294692
98BCKDK0.13878325
99CDK40.13863069
100PRKCB0.13463919

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.01194778
2Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046503.15104818
3T cell receptor signaling pathway_Homo sapiens_hsa046603.13921575
4Graft-versus-host disease_Homo sapiens_hsa053323.02414823
5Measles_Homo sapiens_hsa051622.87844416
6Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.85260889
7Autoimmune thyroid disease_Homo sapiens_hsa053202.83763000
8RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.61195495
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.46199584
10Antigen processing and presentation_Homo sapiens_hsa046122.40172222
11Allograft rejection_Homo sapiens_hsa053302.39853627
12Toll-like receptor signaling pathway_Homo sapiens_hsa046202.23873909
13NF-kappa B signaling pathway_Homo sapiens_hsa040642.20225898
14Hematopoietic cell lineage_Homo sapiens_hsa046401.94858633
15Hepatitis B_Homo sapiens_hsa051611.88393627
16Selenocompound metabolism_Homo sapiens_hsa004501.82294630
17Nucleotide excision repair_Homo sapiens_hsa034201.81759945
18Mismatch repair_Homo sapiens_hsa034301.80714039
19One carbon pool by folate_Homo sapiens_hsa006701.72072442
20Homologous recombination_Homo sapiens_hsa034401.71835542
21TNF signaling pathway_Homo sapiens_hsa046681.69214118
22Type I diabetes mellitus_Homo sapiens_hsa049401.50515421
23Jak-STAT signaling pathway_Homo sapiens_hsa046301.50028379
24Intestinal immune network for IgA production_Homo sapiens_hsa046721.46870862
25Malaria_Homo sapiens_hsa051441.45315418
26Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.39567459
27Viral myocarditis_Homo sapiens_hsa054161.37044000
28Influenza A_Homo sapiens_hsa051641.35561847
29Osteoclast differentiation_Homo sapiens_hsa043801.32237789
30Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.31842773
31Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.22237932
32Rheumatoid arthritis_Homo sapiens_hsa053231.22041633
33Chemokine signaling pathway_Homo sapiens_hsa040621.19406009
34Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.17285694
35Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.16164632
36Basal transcription factors_Homo sapiens_hsa030221.11550929
37Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.08635777
38Leishmaniasis_Homo sapiens_hsa051401.04588459
39Viral carcinogenesis_Homo sapiens_hsa052031.04509209
40B cell receptor signaling pathway_Homo sapiens_hsa046620.99886961
41Salmonella infection_Homo sapiens_hsa051320.98467144
42Apoptosis_Homo sapiens_hsa042100.97510038
43African trypanosomiasis_Homo sapiens_hsa051430.94931047
44NOD-like receptor signaling pathway_Homo sapiens_hsa046210.91721223
45Proteasome_Homo sapiens_hsa030500.89853293
46Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.89255262
47N-Glycan biosynthesis_Homo sapiens_hsa005100.87252380
48Staphylococcus aureus infection_Homo sapiens_hsa051500.86736802
49HTLV-I infection_Homo sapiens_hsa051660.86010643
50Fanconi anemia pathway_Homo sapiens_hsa034600.81070065
51Amphetamine addiction_Homo sapiens_hsa050310.79597634
52Glycerophospholipid metabolism_Homo sapiens_hsa005640.78724773
53Shigellosis_Homo sapiens_hsa051310.76637467
54Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.75267822
55Herpes simplex infection_Homo sapiens_hsa051680.75211427
56Tuberculosis_Homo sapiens_hsa051520.72000397
57Cocaine addiction_Homo sapiens_hsa050300.71909687
58Colorectal cancer_Homo sapiens_hsa052100.71683107
59Aldosterone synthesis and secretion_Homo sapiens_hsa049250.69828302
60Pancreatic cancer_Homo sapiens_hsa052120.68649614
61alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.68376404
62Epstein-Barr virus infection_Homo sapiens_hsa051690.68077156
63Sphingolipid signaling pathway_Homo sapiens_hsa040710.66258747
64Asthma_Homo sapiens_hsa053100.65877151
65Platelet activation_Homo sapiens_hsa046110.62785761
66Hepatitis C_Homo sapiens_hsa051600.61000448
67Dorso-ventral axis formation_Homo sapiens_hsa043200.60856470
68Insulin resistance_Homo sapiens_hsa049310.59224553
69Phosphatidylinositol signaling system_Homo sapiens_hsa040700.58937961
70Prion diseases_Homo sapiens_hsa050200.57910091
71Toxoplasmosis_Homo sapiens_hsa051450.57743682
72Acute myeloid leukemia_Homo sapiens_hsa052210.53175132
73SNARE interactions in vesicular transport_Homo sapiens_hsa041300.50013586
74Non-small cell lung cancer_Homo sapiens_hsa052230.46519446
75Linoleic acid metabolism_Homo sapiens_hsa005910.44388700
76Thyroid cancer_Homo sapiens_hsa052160.43648887
77Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.43068567
78Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.40428403
79MAPK signaling pathway_Homo sapiens_hsa040100.39772665
80Legionellosis_Homo sapiens_hsa051340.39369471
81Endocytosis_Homo sapiens_hsa041440.37422896
82Pertussis_Homo sapiens_hsa051330.36426756
83Carbohydrate digestion and absorption_Homo sapiens_hsa049730.34985347
84Glycerolipid metabolism_Homo sapiens_hsa005610.34507146
85Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.33223996
86AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.31166799
87Chronic myeloid leukemia_Homo sapiens_hsa052200.29574187
88Longevity regulating pathway - mammal_Homo sapiens_hsa042110.29224103
89Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.29065223
90Thyroid hormone synthesis_Homo sapiens_hsa049180.28995282
91Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.28466986
92Choline metabolism in cancer_Homo sapiens_hsa052310.27423165
93Glucagon signaling pathway_Homo sapiens_hsa049220.26476821
94VEGF signaling pathway_Homo sapiens_hsa043700.22682650
95Insulin secretion_Homo sapiens_hsa049110.21385324
96Neurotrophin signaling pathway_Homo sapiens_hsa047220.20206898
97Prolactin signaling pathway_Homo sapiens_hsa049170.19377268
98Olfactory transduction_Homo sapiens_hsa047400.19259781
99FoxO signaling pathway_Homo sapiens_hsa040680.18472483
100Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.16908034

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