TRBV23-1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of growth hormone secretion (GO:0060124)8.56505749
2growth hormone secretion (GO:0030252)7.86261904
3NIK/NF-kappaB signaling (GO:0038061)7.65302545
4natural killer cell differentiation (GO:0001779)6.65165171
5determination of adult lifespan (GO:0008340)6.42971720
6antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.96462561
7positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.80302918
8negative T cell selection (GO:0043383)5.74767973
9regulation of growth hormone secretion (GO:0060123)5.65436343
10negative thymic T cell selection (GO:0045060)5.64996090
11regulation of antigen processing and presentation of peptide antigen (GO:0002583)5.06193389
12negative regulation of cell killing (GO:0031342)4.98976336
13negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.98976336
14phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)4.97861605
15positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)4.86261616
16positive thymic T cell selection (GO:0045059)4.72400849
17Arp2/3 complex-mediated actin nucleation (GO:0034314)4.62980651
18nucleoside diphosphate catabolic process (GO:0009134)4.61544648
19regulation of B cell receptor signaling pathway (GO:0050855)4.61385272
20regulation of gamma-delta T cell differentiation (GO:0045586)4.59512144
21positive T cell selection (GO:0043368)4.58511474
22positive regulation of gamma-delta T cell activation (GO:0046645)4.57955356
23thymic T cell selection (GO:0045061)4.55227156
24negative regulation of phagocytosis (GO:0050765)4.49686154
25regulation of RIG-I signaling pathway (GO:0039535)4.47514790
26regulation of T cell tolerance induction (GO:0002664)4.30638450
27regulation of isotype switching to IgG isotypes (GO:0048302)4.21561681
28T cell selection (GO:0045058)4.13732335
29female mating behavior (GO:0060180)4.10758062
30regulation of female receptivity (GO:0045924)4.09283725
31regulation of gamma-delta T cell activation (GO:0046643)4.07418963
32positive regulation of tolerance induction (GO:0002645)4.03343774
33antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.98369169
34purine deoxyribonucleotide catabolic process (GO:0009155)3.94597018
35positive regulation of natural killer cell mediated immunity (GO:0002717)3.93755964
36regulation of natural killer cell mediated immunity (GO:0002715)3.91186988
37regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.91186988
38regulation of G0 to G1 transition (GO:0070316)3.87856747
39T cell receptor signaling pathway (GO:0050852)3.86464813
40regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.84423805
41regulation of T cell mediated cytotoxicity (GO:0001914)3.81969637
42adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.76365153
43mucosal-associated lymphoid tissue development (GO:0048537)3.75958878
44Peyers patch development (GO:0048541)3.75958878
45antigen processing and presentation of endogenous antigen (GO:0019883)3.75738857
46actin nucleation (GO:0045010)3.75688105
47regulation of leukocyte mediated cytotoxicity (GO:0001910)3.75071540
48positive regulation of granulocyte differentiation (GO:0030854)3.73925137
49response to UV-C (GO:0010225)3.70668268
50autophagic vacuole fusion (GO:0000046)3.66279292
51glomerular visceral epithelial cell development (GO:0072015)3.65635728
52antigen receptor-mediated signaling pathway (GO:0050851)3.62980082
53negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.60049931
54positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.59680385
55regulation of tolerance induction (GO:0002643)3.59013307
56regulation of alpha-beta T cell proliferation (GO:0046640)3.59006608
57positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.58817490
58coenzyme catabolic process (GO:0009109)3.57917535
59regulation of regulatory T cell differentiation (GO:0045589)3.57760376
60lymph node development (GO:0048535)3.52966787
61cellular response to interleukin-15 (GO:0071350)3.49666318
62activated T cell proliferation (GO:0050798)3.46154895
63positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.45035894
64negative regulation of T cell mediated immunity (GO:0002710)3.43309792
65antigen processing and presentation via MHC class Ib (GO:0002475)3.42704983
66response to interleukin-15 (GO:0070672)3.40327817
67activation of adenylate cyclase activity (GO:0007190)3.40265970
68regulation of necroptotic process (GO:0060544)3.39881066
69natural killer cell activation (GO:0030101)3.37032716
70negative regulation of Ras GTPase activity (GO:0034261)3.33738352
71regulation of cell killing (GO:0031341)3.33301888
72regulation of metalloenzyme activity (GO:0048552)3.33145343
73antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.32886853
74tolerance induction (GO:0002507)3.31589640
75respiratory burst (GO:0045730)3.31127120
76I-kappaB phosphorylation (GO:0007252)3.27907817
77T cell migration (GO:0072678)3.27498131
78positive regulation of T cell mediated cytotoxicity (GO:0001916)3.26467300
79regulation of insulin-like growth factor receptor signaling pathway (GO:0043567)3.24225836
80positive regulation of cell killing (GO:0031343)3.21880189
81regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.21137580
82glomerular epithelial cell development (GO:0072310)3.19408999
83regulation of protein heterodimerization activity (GO:0043497)3.14642412
84regulation of antigen processing and presentation (GO:0002577)3.12524381
85regulation of interleukin-2 biosynthetic process (GO:0045076)3.11390868
86adaptation of signaling pathway (GO:0023058)3.11114583
87purine deoxyribonucleotide metabolic process (GO:0009151)3.08328067
88negative regulation of telomere maintenance (GO:0032205)3.08138822
89regulation of B cell differentiation (GO:0045577)3.05807309
90positive regulation of B cell differentiation (GO:0045579)3.02251491
91neutrophil activation involved in immune response (GO:0002283)3.01206581
92modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.00705209
93positive regulation by organism of defense response of other organism involved in symbiotic interact3.00705209
94modulation by symbiont of host immune response (GO:0052553)3.00705209
95positive regulation by symbiont of host defense response (GO:0052509)3.00705209
96modulation by symbiont of host defense response (GO:0052031)3.00705209
97modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.00705209
98negative regulation of glycoprotein biosynthetic process (GO:0010561)2.99073856
99type I interferon signaling pathway (GO:0060337)2.98743385
100cellular response to type I interferon (GO:0071357)2.98743385

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.74322700
2IRF8_22096565_ChIP-ChIP_GC-B_Human5.66462343
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.56879736
4ELF1_17652178_ChIP-ChIP_JURKAT_Human5.17017520
5BP1_19119308_ChIP-ChIP_Hs578T_Human4.06008340
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.59652563
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.42956349
8IRF8_21731497_ChIP-ChIP_J774_Mouse3.42186151
9MYB_26560356_Chip-Seq_TH2_Human3.11790270
10RUNX_20019798_ChIP-Seq_JUKART_Human3.02934255
11RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.93311937
12CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.88647826
13MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.81423486
14UTX_26944678_Chip-Seq_JUKART_Human2.74813778
15MAF_26560356_Chip-Seq_TH1_Human2.61688946
16STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.61438254
17MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.58946803
18SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.48612991
19MYB_26560356_Chip-Seq_TH1_Human2.43643185
20MAF_26560356_Chip-Seq_TH2_Human2.28197766
21FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.25133014
22GATA3_27048872_Chip-Seq_THYMUS_Human2.21882853
23SCL_19346495_ChIP-Seq_HPC-7_Human2.20176739
24IRF8_27001747_Chip-Seq_BMDM_Mouse2.12568624
25STAT4_19710469_ChIP-ChIP_TH1__Mouse2.11585728
26E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.00699317
27SPI1_23547873_ChIP-Seq_NB4_Human1.98954206
28SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.89269467
29MYC_22102868_ChIP-Seq_BL_Human1.85584184
30VDR_24763502_ChIP-Seq_THP-1_Human1.78600353
31GATA3_26560356_Chip-Seq_TH2_Human1.74660495
32LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.72765314
33LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.70768003
34GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.68076737
35MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.60407067
36GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.59615348
37RUNX1_22412390_ChIP-Seq_EML_Mouse1.57235987
38VDR_21846776_ChIP-Seq_THP-1_Human1.53409444
39SPI1_23127762_ChIP-Seq_K562_Human1.50611636
40BCL6_27268052_Chip-Seq_Bcells_Human1.50392587
41KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.50041187
42FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.47915563
43BRD4_27068464_Chip-Seq_AML-cells_Mouse1.44978370
44MYB_21317192_ChIP-Seq_ERMYB_Mouse1.41471161
45NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.39382478
46SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human1.38353148
47BCOR_27268052_Chip-Seq_Bcells_Human1.38156222
48PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.36125331
49VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.31662345
50SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.25655439
51TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.17063854
52CIITA_25753668_ChIP-Seq_RAJI_Human1.16994040
53RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.16208341
54KDM2B_26808549_Chip-Seq_DND41_Human1.14993157
55TCF7_22412390_ChIP-Seq_EML_Mouse1.13898168
56SPI1_20517297_ChIP-Seq_HL60_Human1.12185641
57KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.11811688
58TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.09926472
59GATA2_22383799_ChIP-Seq_G1ME_Mouse1.08774045
60TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.07590060
61VDR_23849224_ChIP-Seq_CD4+_Human1.07492302
62RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.06218080
63EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.02932210
64SA1_27219007_Chip-Seq_Bcells_Human1.02005938
65FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01203819
66KDM2B_26808549_Chip-Seq_SUP-B15_Human1.00309431
67GATA1_19941826_ChIP-Seq_K562_Human0.99482411
68RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.99418827
69KDM2B_26808549_Chip-Seq_JURKAT_Human0.98643129
70SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.97761855
71DROSHA_22980978_ChIP-Seq_HELA_Human0.97366443
72CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96778463
73PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95700066
74NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.94615907
75SMAD_19615063_ChIP-ChIP_OVARY_Human0.94157870
76CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.93861868
77VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.93819219
78ELK3_25401928_ChIP-Seq_HUVEC_Human0.93107754
79TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.92243506
80SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.92153074
81CTCF_27219007_Chip-Seq_ERYTHROID_Human0.91714337
82NFE2_27457419_Chip-Seq_LIVER_Mouse0.91284376
83P300_27268052_Chip-Seq_Bcells_Human0.91118433
84CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90684069
85E2F1_20622854_ChIP-Seq_HELA_Human0.90527874
86PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89609134
87TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.88879844
88CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.88759790
89ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.88387925
90LXR_22292898_ChIP-Seq_THP-1_Human0.85204066
91FOXP3_21729870_ChIP-Seq_TREG_Human0.84735087
92CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.83586086
93SUZ12_27294783_Chip-Seq_NPCs_Mouse0.82595682
94ETS1_21867929_ChIP-Seq_TH2_Mouse0.82557413
95NOTCH1_21737748_ChIP-Seq_TLL_Human0.81412299
96RAC3_21632823_ChIP-Seq_H3396_Human0.81187929
97PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.80595679
98GATA1_22383799_ChIP-Seq_G1ME_Mouse0.80181032
99GATA1_19941827_ChIP-Seq_MEL_Mouse0.79640955
100GATA2_21666600_ChIP-Seq_HMVEC_Human0.78712247

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.60627703
2MP0003763_abnormal_thymus_physiology4.37195326
3MP0001501_abnormal_sleep_pattern3.54673918
4MP0001800_abnormal_humoral_immune3.04001339
5MP0002909_abnormal_adrenal_gland3.00350668
6MP0009333_abnormal_splenocyte_physiolog2.81872113
7MP0000015_abnormal_ear_pigmentation2.81253362
8MP0001835_abnormal_antigen_presentation2.75877302
9MP0005000_abnormal_immune_tolerance2.67644090
10MP0002277_abnormal_respiratory_mucosa2.65130931
11MP0003436_decreased_susceptibility_to2.63634100
12MP0005025_abnormal_response_to2.63381839
13MP0002723_abnormal_immune_serum2.63341407
14MP0002420_abnormal_adaptive_immunity2.54155710
15MP0003866_abnormal_defecation2.52329925
16MP0001819_abnormal_immune_cell2.50231225
17MP0000685_abnormal_immune_system2.42976447
18MP0002452_abnormal_antigen_presenting2.37932358
19MP0009785_altered_susceptibility_to2.37028994
20MP0004381_abnormal_hair_follicle2.35244120
21MP0005387_immune_system_phenotype2.31095277
22MP0001790_abnormal_immune_system2.31095277
23MP0002405_respiratory_system_inflammati2.30289286
24MP0002398_abnormal_bone_marrow2.14986623
25MP0003724_increased_susceptibility_to2.09845494
26MP0000716_abnormal_immune_system2.05175125
27MP0002148_abnormal_hypersensitivity_rea2.02911539
28MP0002419_abnormal_innate_immunity2.02083064
29MP0002132_abnormal_respiratory_system1.98809476
30MP0001881_abnormal_mammary_gland1.94549145
31MP0000703_abnormal_thymus_morphology1.89027865
32MP0003787_abnormal_imprinting1.87106896
33MP0002102_abnormal_ear_morphology1.71256023
34MP0010155_abnormal_intestine_physiology1.71184154
35MP0000689_abnormal_spleen_morphology1.69713386
36MP0002933_joint_inflammation1.66608829
37MP0002166_altered_tumor_susceptibility1.59931658
38MP0005464_abnormal_platelet_physiology1.59712943
39MP0002722_abnormal_immune_system1.58106731
40MP0002429_abnormal_blood_cell1.56542108
41MP0001873_stomach_inflammation1.55632318
42MP0004947_skin_inflammation1.52774546
43MP0001845_abnormal_inflammatory_respons1.49984703
44MP0003303_peritoneal_inflammation1.47981894
45MP0001533_abnormal_skeleton_physiology1.47309795
46MP0005075_abnormal_melanosome_morpholog1.42876571
47MP0003786_premature_aging1.37347412
48MP0003959_abnormal_lean_body1.33268732
49MP0005266_abnormal_metabolism1.30093363
50MP0006082_CNS_inflammation1.29071477
51MP0008260_abnormal_autophagy1.28849338
52MP0006276_abnormal_autonomic_nervous1.27505971
53MP0001851_eye_inflammation1.25712488
54MP0003172_abnormal_lysosome_physiology1.25053958
55MP0008469_abnormal_protein_level1.19744327
56MP0002396_abnormal_hematopoietic_system1.15921131
57MP0003183_abnormal_peptide_metabolism1.15365781
58MP0002254_reproductive_system_inflammat1.12099632
59MP0003300_gastrointestinal_ulcer1.10783773
60MP0008961_abnormal_basal_metabolism1.10763064
61MP0000465_gastrointestinal_hemorrhage1.07839837
62MP0001853_heart_inflammation1.05098447
63MP0008872_abnormal_physiological_respon1.01537740
64MP0002006_tumorigenesis1.00580539
65MP0006035_abnormal_mitochondrial_morpho0.99981208
66MP0001348_abnormal_lacrimal_gland0.97919216
67MP0002136_abnormal_kidney_physiology0.96754928
68MP0002095_abnormal_skin_pigmentation0.94188643
69MP0008058_abnormal_DNA_repair0.91131219
70MP0009278_abnormal_bone_marrow0.91038287
71MP0000920_abnormal_myelination0.89937101
72MP0000230_abnormal_systemic_arterial0.89387750
73MP0008877_abnormal_DNA_methylation0.88720518
74MP0003795_abnormal_bone_structure0.87459768
75MP0009764_decreased_sensitivity_to0.85505716
76MP0000490_abnormal_crypts_of0.84521901
77MP0005451_abnormal_body_composition0.84166198
78MP0005248_abnormal_Harderian_gland0.83887410
79MP0002019_abnormal_tumor_incidence0.83463388
80MP0005174_abnormal_tail_pigmentation0.83005313
81MP0002138_abnormal_hepatobiliary_system0.82516392
82MP0000858_altered_metastatic_potential0.81277693
83MP0005164_abnormal_response_to0.79293108
84MP0009384_cardiac_valve_regurgitation0.79024064
85MP0002998_abnormal_bone_remodeling0.73445612
86MP0002693_abnormal_pancreas_physiology0.71936390
87MP0006036_abnormal_mitochondrial_physio0.68984491
88MP0005376_homeostasis/metabolism_phenot0.67789777
89MP0004883_abnormal_blood_vessel0.67199968
90MP0002163_abnormal_gland_morphology0.66141616
91MP0009643_abnormal_urine_homeostasis0.63576706
92MP0008995_early_reproductive_senescence0.63440017
93MP0001119_abnormal_female_reproductive0.60552926
94MP0003806_abnormal_nucleotide_metabolis0.60299007
95MP0008873_increased_physiological_sensi0.59167854
96MP0003075_altered_response_to0.58242130
97MP0008874_decreased_physiological_sensi0.57549309
98MP0001663_abnormal_digestive_system0.53995554
99MP0002168_other_aberrant_phenotype0.52612911
100MP0005310_abnormal_salivary_gland0.51844472

Predicted human phenotypes

RankGene SetZ-score
1Sensory axonal neuropathy (HP:0003390)7.80646174
2Severe visual impairment (HP:0001141)5.76971692
3Slow saccadic eye movements (HP:0000514)5.69382387
4Elevated erythrocyte sedimentation rate (HP:0003565)5.44773224
5Keratoconjunctivitis sicca (HP:0001097)5.04943985
6T lymphocytopenia (HP:0005403)4.87383795
7Cerebral hypomyelination (HP:0006808)4.67680684
8Keratoconjunctivitis (HP:0001096)4.64994129
9Abnormality of T cell number (HP:0011839)4.27219215
10Recurrent skin infections (HP:0001581)4.16088618
11Spastic paraparesis (HP:0002313)3.90588143
12Stomatitis (HP:0010280)3.80010329
13Prostate neoplasm (HP:0100787)3.65248428
14Pustule (HP:0200039)3.62443469
15Aplastic anemia (HP:0001915)3.58284069
16Myositis (HP:0100614)3.53763723
17Palpebral edema (HP:0100540)3.52946328
18Severe combined immunodeficiency (HP:0004430)3.44115948
19Tubulointerstitial fibrosis (HP:0005576)3.37880073
20Eczematoid dermatitis (HP:0000976)3.29902690
21Retinal atrophy (HP:0001105)3.29380117
22IgG deficiency (HP:0004315)3.28132530
23Keratitis (HP:0000491)3.26930429
24Abnormality of T cells (HP:0002843)3.17064888
25Recurrent bacterial skin infections (HP:0005406)3.15942629
26Cellulitis (HP:0100658)3.15116189
27Chronic mucocutaneous candidiasis (HP:0002728)3.09442483
28Recurrent cutaneous fungal infections (HP:0011370)3.09442483
29Poor speech (HP:0002465)3.04369250
30Recurrent abscess formation (HP:0002722)3.02020371
31Chronic diarrhea (HP:0002028)2.95411413
32Pigmentary retinal degeneration (HP:0001146)2.92356553
33Increased IgM level (HP:0003496)2.88693745
34Abnormal umbilical cord blood vessels (HP:0011403)2.87636446
35Single umbilical artery (HP:0001195)2.87636446
36Abnormality of the fetal cardiovascular system (HP:0010948)2.87636446
37CNS hypomyelination (HP:0003429)2.84084077
38Abnormality of the prostate (HP:0008775)2.83849137
39Spontaneous hematomas (HP:0007420)2.83570822
40Encephalitis (HP:0002383)2.78427604
41Recurrent fungal infections (HP:0002841)2.77113343
42Growth hormone deficiency (HP:0000824)2.73111740
43Acute hepatic failure (HP:0006554)2.67817218
44Amblyopia (HP:0000646)2.64661134
45Combined immunodeficiency (HP:0005387)2.61717057
46Meningitis (HP:0001287)2.61356936
47Episodic fever (HP:0001954)2.55789273
48Optic neuritis (HP:0100653)2.55558425
49Retrobulbar optic neuritis (HP:0100654)2.55558425
50Increased neuronal autofluorescent lipopigment (HP:0002074)2.50047279
51Mediastinal lymphadenopathy (HP:0100721)2.49849542
52Orchitis (HP:0100796)2.48804299
53Tubular atrophy (HP:0000092)2.48301573
54Autoimmune hemolytic anemia (HP:0001890)2.44858714
55Recurrent corneal erosions (HP:0000495)2.34197849
56Hypoalbuminemia (HP:0003073)2.30239699
57Abnormal albumin level (HP:0012116)2.30239699
58Increased intramyocellular lipid droplets (HP:0012240)2.27858170
59Increased cerebral lipofuscin (HP:0011813)2.27767754
60Verrucae (HP:0200043)2.27716371
61Papilloma (HP:0012740)2.27716371
62Increased muscle lipid content (HP:0009058)2.25808261
63Lymphopenia (HP:0001888)2.25068506
64Obstructive lung disease (HP:0006536)2.23541999
65Chronic obstructive pulmonary disease (HP:0006510)2.23541999
66Vasculitis (HP:0002633)2.23343273
67IgM deficiency (HP:0002850)2.23143098
68Intention tremor (HP:0002080)2.23139223
69Oral leukoplakia (HP:0002745)2.22242891
70Hypoplastic left heart (HP:0004383)2.19408584
71Granulocytopenia (HP:0001913)2.19225181
72Gastrointestinal infarctions (HP:0005244)2.18604188
73Abnormal drinking behavior (HP:0030082)2.17348207
74Polydipsia (HP:0001959)2.17348207
75Agammaglobulinemia (HP:0004432)2.17175840
76Progressive visual loss (HP:0000529)2.16557276
77Abnormality of saccadic eye movements (HP:0000570)2.15813504
78Panhypogammaglobulinemia (HP:0003139)2.13858580
79Hepatocellular necrosis (HP:0001404)2.13030466
80Microvesicular hepatic steatosis (HP:0001414)2.11655204
81Abnormal delayed hypersensitivity skin test (HP:0002963)2.10394207
82Abnormality of macrophages (HP:0004311)2.10119825
83Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.09670014
84Micronodular cirrhosis (HP:0001413)2.06063776
85Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.05769834
86Urticaria (HP:0001025)2.03507065
87Petechiae (HP:0000967)2.01977240
88Stage 5 chronic kidney disease (HP:0003774)2.01628473
89Leukocytosis (HP:0001974)2.00684637
90Prolonged bleeding time (HP:0003010)1.99931771
91Cellular immunodeficiency (HP:0005374)1.99750303
92Paraparesis (HP:0002385)1.98238926
93Abnormality of cells of the lymphoid lineage (HP:0012140)1.97524961
94Abnormality of eosinophils (HP:0001879)1.95576435
95Mask-like facies (HP:0000298)1.95046884
96Recurrent gram-negative bacterial infections (HP:0005420)1.94125714
97Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.92087865
98Complete atrioventricular canal defect (HP:0001674)1.89982571
99Tubulointerstitial abnormality (HP:0001969)1.89748886
100Abnormal number of erythroid precursors (HP:0012131)1.88499774

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.97884285
2TESK24.80587290
3TXK4.27818764
4MAP3K63.68866032
5CAMKK23.15676453
6BCKDK3.12151523
7KDR3.09309865
8IRAK43.07548928
9MAP3K123.04236150
10IKBKE2.87783656
11DAPK12.39679442
12CDK192.31132481
13ZAP702.23106803
14GRK62.13687383
15TESK12.01966661
16VRK22.01482625
17MAP3K41.94154575
18ITK1.90681621
19TAOK31.78916739
20MAPKAPK31.67433194
21SYK1.66772233
22BMX1.66467708
23FES1.66432782
24TYK21.60503904
25RPS6KA41.49359093
26CSK1.44976207
27BTK1.43390754
28CAMKK11.42110244
29LCK1.39993285
30SIK31.30515392
31MYLK1.15113625
32HCK1.13272978
33LIMK11.11482274
34PASK1.08334919
35CSF1R1.00416482
36JAK30.98272483
37VRK10.97434509
38TEC0.92119133
39TNK20.86716426
40RIPK40.85393213
41MARK30.85205542
42LYN0.81300470
43SIK20.80410739
44PRKCH0.73149690
45CDK120.73011709
46PRKD30.72795792
47MAP3K140.72159281
48IKBKB0.70412076
49BLK0.70396872
50PRKCQ0.65701360
51MAP3K110.64419227
52BRSK20.63812679
53KIT0.60370252
54ERN10.59001761
55PRPF4B0.58692975
56MAPKAPK20.56986088
57NME10.55813638
58DDR20.54782135
59LRRK20.51982896
60FYN0.51796534
61JAK10.50553569
62MAP3K10.45761349
63TBK10.44731426
64BRD40.43557771
65HIPK20.43543786
66CAMK10.43198376
67JAK20.39174165
68CLK10.38687967
69ERBB30.37704612
70PIM10.37014797
71MST40.36587113
72EPHA30.36550378
73NLK0.34737820
74TAOK10.31342284
75STK110.31179271
76PDK10.29647294
77STK40.29397318
78EPHB10.29206459
79TRPM70.27151571
80MAPK40.26409598
81CDK40.24504003
82INSR0.23941340
83MAPK70.23926084
84MAP3K30.23653837
85PAK40.23310179
86MAPK120.23302599
87SMG10.23061183
88PDGFRB0.22511522
89STK100.21732639
90IGF1R0.21257883
91CHUK0.20762535
92KSR20.20701270
93CAMK2B0.20336457
94NEK60.18493558
95PRKD10.18375476
96RPS6KA50.18361671
97PRKCB0.18290393
98MAPK110.18253448
99PRKAA10.17941546
100MAPK30.16896677

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.35128258
2Graft-versus-host disease_Homo sapiens_hsa053323.24494518
3T cell receptor signaling pathway_Homo sapiens_hsa046603.10811942
4Autoimmune thyroid disease_Homo sapiens_hsa053203.00412774
5Allograft rejection_Homo sapiens_hsa053302.99219123
6Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.84884293
7Antigen processing and presentation_Homo sapiens_hsa046122.72008580
8Measles_Homo sapiens_hsa051622.70427689
9Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.69295362
10Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.62307374
11Non-homologous end-joining_Homo sapiens_hsa034502.60439936
12Hematopoietic cell lineage_Homo sapiens_hsa046402.38565877
13Type I diabetes mellitus_Homo sapiens_hsa049402.14506201
14Intestinal immune network for IgA production_Homo sapiens_hsa046721.98842115
15NF-kappa B signaling pathway_Homo sapiens_hsa040641.88426682
16Herpes simplex infection_Homo sapiens_hsa051681.88100946
17Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.76053521
18Viral myocarditis_Homo sapiens_hsa054161.69068365
19Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.68385230
20Sulfur relay system_Homo sapiens_hsa041221.67123284
21Leishmaniasis_Homo sapiens_hsa051401.64670700
22Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.61203397
23SNARE interactions in vesicular transport_Homo sapiens_hsa041301.57469248
24RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.47001080
25Osteoclast differentiation_Homo sapiens_hsa043801.44914172
26Toll-like receptor signaling pathway_Homo sapiens_hsa046201.41236161
27Staphylococcus aureus infection_Homo sapiens_hsa051501.39601954
28NOD-like receptor signaling pathway_Homo sapiens_hsa046211.37860310
29Regulation of autophagy_Homo sapiens_hsa041401.27370818
30Malaria_Homo sapiens_hsa051441.21573749
31Proteasome_Homo sapiens_hsa030501.20122355
32Circadian rhythm_Homo sapiens_hsa047101.20105825
33Shigellosis_Homo sapiens_hsa051311.14474215
34Ribosome_Homo sapiens_hsa030101.10837238
35Asthma_Homo sapiens_hsa053101.09690241
36Rheumatoid arthritis_Homo sapiens_hsa053231.07991050
37Oxidative phosphorylation_Homo sapiens_hsa001901.04137028
38Tuberculosis_Homo sapiens_hsa051521.03934674
39Acute myeloid leukemia_Homo sapiens_hsa052211.03294669
40Influenza A_Homo sapiens_hsa051641.03267993
41Jak-STAT signaling pathway_Homo sapiens_hsa046300.93425569
42Legionellosis_Homo sapiens_hsa051340.93173593
43B cell receptor signaling pathway_Homo sapiens_hsa046620.90023068
44Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.88401546
45Peroxisome_Homo sapiens_hsa041460.85245452
46Leukocyte transendothelial migration_Homo sapiens_hsa046700.82984296
47Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.82621486
48TNF signaling pathway_Homo sapiens_hsa046680.81894854
49Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.81763265
50Salmonella infection_Homo sapiens_hsa051320.81695401
51Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.80717498
52Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.80559493
53Chemokine signaling pathway_Homo sapiens_hsa040620.79684547
54Viral carcinogenesis_Homo sapiens_hsa052030.72165103
55Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.71343906
56Hepatitis C_Homo sapiens_hsa051600.71282574
57Chemical carcinogenesis_Homo sapiens_hsa052040.70626299
58Carbohydrate digestion and absorption_Homo sapiens_hsa049730.70260229
59Epstein-Barr virus infection_Homo sapiens_hsa051690.70061758
60Platelet activation_Homo sapiens_hsa046110.69418000
61Parkinsons disease_Homo sapiens_hsa050120.65345262
62HTLV-I infection_Homo sapiens_hsa051660.64832482
63Base excision repair_Homo sapiens_hsa034100.64564052
64Endocytosis_Homo sapiens_hsa041440.62998116
65Phagosome_Homo sapiens_hsa041450.61070912
66Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.58661429
67Pyrimidine metabolism_Homo sapiens_hsa002400.57516762
68Toxoplasmosis_Homo sapiens_hsa051450.57107122
69Pertussis_Homo sapiens_hsa051330.54318245
70Apoptosis_Homo sapiens_hsa042100.52636069
71Huntingtons disease_Homo sapiens_hsa050160.51573337
72RNA degradation_Homo sapiens_hsa030180.51194515
73Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.49773812
74RNA polymerase_Homo sapiens_hsa030200.49652523
75Collecting duct acid secretion_Homo sapiens_hsa049660.47368597
76Regulation of actin cytoskeleton_Homo sapiens_hsa048100.45786102
77African trypanosomiasis_Homo sapiens_hsa051430.44909483
78FoxO signaling pathway_Homo sapiens_hsa040680.44505614
79MAPK signaling pathway_Homo sapiens_hsa040100.43766216
80Hepatitis B_Homo sapiens_hsa051610.42430945
81Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.41586191
82Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.40485886
83Transcriptional misregulation in cancer_Homo sapiens_hsa052020.39641572
84Phosphatidylinositol signaling system_Homo sapiens_hsa040700.35736720
85Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.35090793
86Cyanoamino acid metabolism_Homo sapiens_hsa004600.32662173
87Fanconi anemia pathway_Homo sapiens_hsa034600.31840879
88Purine metabolism_Homo sapiens_hsa002300.29316591
89Non-small cell lung cancer_Homo sapiens_hsa052230.28449085
90Histidine metabolism_Homo sapiens_hsa003400.28360297
91Glycosaminoglycan degradation_Homo sapiens_hsa005310.28192504
92Alzheimers disease_Homo sapiens_hsa050100.26148804
93Linoleic acid metabolism_Homo sapiens_hsa005910.25627057
94Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.24693898
95Homologous recombination_Homo sapiens_hsa034400.22240770
96Notch signaling pathway_Homo sapiens_hsa043300.20670059
97Caffeine metabolism_Homo sapiens_hsa002320.20322796
98Cardiac muscle contraction_Homo sapiens_hsa042600.19549731
99Systemic lupus erythematosus_Homo sapiens_hsa053220.18787985
100Rap1 signaling pathway_Homo sapiens_hsa040150.13960074

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