TRBV25-1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)9.92419844
2lymph node development (GO:0048535)7.92357640
3cytidine metabolic process (GO:0046087)6.64429311
4cytidine catabolic process (GO:0006216)6.64429311
5cytidine deamination (GO:0009972)6.64429311
6modulation of growth of symbiont involved in interaction with host (GO:0044144)6.48848271
7regulation of growth of symbiont in host (GO:0044126)6.48848271
8negative regulation of growth of symbiont in host (GO:0044130)6.48848271
9negative regulation of growth of symbiont involved in interaction with host (GO:0044146)6.48848271
10mast cell activation (GO:0045576)6.23995759
11regulation of inflammatory response to antigenic stimulus (GO:0002861)5.98551586
12pyrimidine ribonucleoside catabolic process (GO:0046133)5.85599419
13positive regulation of B cell mediated immunity (GO:0002714)5.71239931
14positive regulation of immunoglobulin mediated immune response (GO:0002891)5.71239931
15regulation of response to tumor cell (GO:0002834)4.99235103
16positive regulation of response to tumor cell (GO:0002836)4.99235103
17positive regulation of immune response to tumor cell (GO:0002839)4.99235103
18regulation of immune response to tumor cell (GO:0002837)4.99235103
19positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.95759144
20regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.93949767
21activated T cell proliferation (GO:0050798)4.91644055
22DNA deamination (GO:0045006)4.82201507
23protein neddylation (GO:0045116)4.41270505
24purine nucleotide salvage (GO:0032261)4.23733432
25regulation of immunoglobulin mediated immune response (GO:0002889)4.14268116
26hypotonic response (GO:0006971)4.10800640
27regulation of B cell mediated immunity (GO:0002712)4.09102966
28positive regulation of granulocyte differentiation (GO:0030854)4.00100706
29negative regulation of fibroblast proliferation (GO:0048147)3.89030822
30CDP-diacylglycerol biosynthetic process (GO:0016024)3.88100971
31negative regulation of telomere maintenance (GO:0032205)3.67593168
32positive regulation of defense response to virus by host (GO:0002230)3.59117451
33tolerance induction (GO:0002507)3.57242803
34negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.49480851
35pyrimidine nucleoside catabolic process (GO:0046135)3.48758237
36IMP biosynthetic process (GO:0006188)3.48714423
37leukocyte aggregation (GO:0070486)3.47178059
38CDP-diacylglycerol metabolic process (GO:0046341)3.39613468
39phosphatidylglycerol biosynthetic process (GO:0006655)3.38594501
40negative thymic T cell selection (GO:0045060)3.38240245
41T cell homeostasis (GO:0043029)3.38090765
42autophagic vacuole fusion (GO:0000046)3.35822133
43cardiolipin metabolic process (GO:0032048)3.34746392
44mast cell degranulation (GO:0043303)3.32080159
45mast cell activation involved in immune response (GO:0002279)3.32080159
46antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.30590801
47antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.30190908
48negative T cell selection (GO:0043383)3.26790556
49regulation of B cell receptor signaling pathway (GO:0050855)3.21385558
50positive regulation of lymphocyte mediated immunity (GO:0002708)3.17312179
51regulation of humoral immune response (GO:0002920)3.13258446
52transcription from mitochondrial promoter (GO:0006390)3.12636049
53negative regulation of T cell apoptotic process (GO:0070233)3.12289193
54T cell migration (GO:0072678)3.08096214
55positive regulation of adaptive immune response based on somatic recombination of immune receptors b3.06944724
56cellular response to interleukin-15 (GO:0071350)3.02304312
57antigen processing and presentation of endogenous antigen (GO:0019883)2.99939008
58positive regulation of B cell differentiation (GO:0045579)2.99747112
59positive T cell selection (GO:0043368)2.98824330
60T cell proliferation (GO:0042098)2.96386159
61negative regulation of potassium ion transmembrane transport (GO:1901380)2.94901271
62antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.93755382
63water-soluble vitamin biosynthetic process (GO:0042364)2.93567240
64positive regulation of adaptive immune response (GO:0002821)2.90689829
65negative regulation of execution phase of apoptosis (GO:1900118)2.89290625
66regulation of granulocyte differentiation (GO:0030852)2.88948660
67neutrophil activation involved in immune response (GO:0002283)2.87594960
68positive regulation of interferon-gamma production (GO:0032729)2.87412332
69nucleoside transmembrane transport (GO:1901642)2.86059910
70positive regulation of leukocyte mediated immunity (GO:0002705)2.83932616
71IMP metabolic process (GO:0046040)2.82766682
72response to interleukin-15 (GO:0070672)2.82144526
73positive thymic T cell selection (GO:0045059)2.81848423
74positive regulation of gamma-delta T cell activation (GO:0046645)2.81165858
75purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.79676103
76maturation of SSU-rRNA (GO:0030490)2.77534522
77regulation of regulatory T cell differentiation (GO:0045589)2.77034560
78antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.76633620
79hepatocyte apoptotic process (GO:0097284)2.76532291
80necroptotic process (GO:0070266)2.76348330
81regulation of B cell differentiation (GO:0045577)2.74379472
82regulation of lymphocyte mediated immunity (GO:0002706)2.74054545
83regulation of alkaline phosphatase activity (GO:0010692)2.73366128
84NIK/NF-kappaB signaling (GO:0038061)2.72833748
85antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.69656145
86thymic T cell selection (GO:0045061)2.66853408
87regulation of cellular amino acid metabolic process (GO:0006521)2.65690109
88organelle membrane fusion (GO:0090174)2.60517572
89B cell mediated immunity (GO:0019724)2.59028049
90antigen receptor-mediated signaling pathway (GO:0050851)2.58297821
91regulation of isotype switching to IgG isotypes (GO:0048302)2.57146229
92negative regulation of cell killing (GO:0031342)2.56073225
93negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.56073225
94purine-containing compound salvage (GO:0043101)2.54870217
95pseudouridine synthesis (GO:0001522)2.54070626
96T cell selection (GO:0045058)2.52755409
97lymphocyte homeostasis (GO:0002260)2.52458685
98regulation of chronic inflammatory response (GO:0002676)12.4190292
99positive regulation of inflammatory response to antigenic stimulus (GO:0002863)11.8101893
100positive regulation of humoral immune response (GO:0002922)10.0129569

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.56027972
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.29512241
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.04459115
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.95377784
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.54588935
6ELF1_17652178_ChIP-ChIP_JURKAT_Human3.51925318
7GATA1_22025678_ChIP-Seq_K562_Human3.15038536
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.07193401
9SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.05883087
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.04680128
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.98853797
12IRF8_21731497_ChIP-ChIP_J774_Mouse2.83238280
13SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.82080651
14STAT6_21828071_ChIP-Seq_BEAS2B_Human2.76839689
15STAT4_19710469_ChIP-ChIP_TH1__Mouse2.66993619
16RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.52846730
17SRY_22984422_ChIP-ChIP_TESTIS_Rat2.50701942
18MYB_26560356_Chip-Seq_TH2_Human2.44696277
19EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.37721659
20EST1_17652178_ChIP-ChIP_JURKAT_Human2.33688577
21MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.29960190
22LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.29659026
23GABP_17652178_ChIP-ChIP_JURKAT_Human2.23468106
24SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.20998307
25HOXB4_20404135_ChIP-ChIP_EML_Mouse2.19548668
26NOTCH1_21737748_ChIP-Seq_TLL_Human2.08428225
27STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.98401236
28JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.89699963
29TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.85664630
30IRF1_19129219_ChIP-ChIP_H3396_Human1.84290292
31SPI1_23547873_ChIP-Seq_NB4_Human1.81819724
32VDR_23849224_ChIP-Seq_CD4+_Human1.80775542
33GATA3_27048872_Chip-Seq_THYMUS_Human1.80131420
34FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.72550637
35RUNX_20019798_ChIP-Seq_JUKART_Human1.70752755
36MYB_21317192_ChIP-Seq_ERMYB_Mouse1.68739730
37GATA3_26560356_Chip-Seq_TH2_Human1.68599841
38UTX_26944678_Chip-Seq_JUKART_Human1.63866314
39FOXP3_21729870_ChIP-Seq_TREG_Human1.60664062
40MYB_26560356_Chip-Seq_TH1_Human1.60505883
41ETS1_20019798_ChIP-Seq_JURKAT_Human1.57883483
42HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.56842159
43THAP11_20581084_ChIP-Seq_MESCs_Mouse1.56202571
44MAF_26560356_Chip-Seq_TH1_Human1.53816491
45STAT1_20625510_ChIP-Seq_HELA_Human1.47650160
46LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.43810420
47CREB1_15753290_ChIP-ChIP_HEK293T_Human1.43154942
48RUNX1_22412390_ChIP-Seq_EML_Mouse1.34690099
49FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.34549740
50GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.34130243
51SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.32891802
52MAF_26560356_Chip-Seq_TH2_Human1.30726635
53SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.30151499
54EGR1_19032775_ChIP-ChIP_M12_Human1.28502612
55GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.27544567
56IRF8_27001747_Chip-Seq_BMDM_Mouse1.26893690
57ELK1_22589737_ChIP-Seq_MCF10A_Human1.25650160
58HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.22603476
59MYC_22102868_ChIP-Seq_BL_Human1.21916767
60FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.21015270
61E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.20462771
62ELK1_19687146_ChIP-ChIP_HELA_Human1.19716632
63GATA1_22383799_ChIP-Seq_G1ME_Mouse1.18696099
64RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.17736607
65CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.16459718
66CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.15862687
67PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12616742
68BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.12362349
69IGF1R_20145208_ChIP-Seq_DFB_Human1.11690272
70FLI1_27457419_Chip-Seq_LIVER_Mouse1.11579175
71SALL4_22934838_ChIP-ChIP_CD34+_Human1.11522753
72BP1_19119308_ChIP-ChIP_Hs578T_Human1.11196131
73PU.1_20513432_ChIP-Seq_Bcells_Mouse1.10943269
74MYC_18358816_ChIP-ChIP_MESCs_Mouse1.09900546
75YY1_21170310_ChIP-Seq_MESCs_Mouse1.07283983
76MYC_18555785_ChIP-Seq_MESCs_Mouse1.07219870
77SPI1_23127762_ChIP-Seq_K562_Human1.06473071
78GATA3_26560356_Chip-Seq_TH1_Human1.03932920
79CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01903035
80Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.01386401
81HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.01058411
82NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.00741231
83GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99493145
84SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.98350089
85SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97480613
86EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.97028398
87MYC_19079543_ChIP-ChIP_MESCs_Mouse0.96072562
88CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.95227137
89E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.95066160
90VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.94173383
91PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.94148448
92ELK4_26923725_Chip-Seq_MESODERM_Mouse0.93568548
93GATA1_19941827_ChIP-Seq_MEL_Mouse0.92917258
94STAT3_1855785_ChIP-Seq_MESCs_Mouse0.92344719
95PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.90499420
96SCL_19346495_ChIP-Seq_HPC-7_Human0.88361041
97CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.87403120
98CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.86516138
99ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.86009172
100SRF_21415370_ChIP-Seq_HL-1_Mouse0.85416939

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003436_decreased_susceptibility_to6.02534230
2MP0000685_abnormal_immune_system5.82799953
3MP0009785_altered_susceptibility_to3.99405586
4MP0001501_abnormal_sleep_pattern3.73040418
5MP0003763_abnormal_thymus_physiology3.43518873
6MP0009764_decreased_sensitivity_to3.39862959
7MP0005671_abnormal_response_to3.36907667
8MP0005464_abnormal_platelet_physiology3.06736401
9MP0001835_abnormal_antigen_presentation2.87136045
10MP0005000_abnormal_immune_tolerance2.77293733
11MP0001800_abnormal_humoral_immune2.72731551
12MP0002405_respiratory_system_inflammati2.68406992
13MP0001533_abnormal_skeleton_physiology2.46218247
14MP0005165_increased_susceptibility_to2.22977908
15MP0000703_abnormal_thymus_morphology2.11684916
16MP0002398_abnormal_bone_marrow2.06050062
17MP0009333_abnormal_splenocyte_physiolog2.00877742
18MP0002452_abnormal_antigen_presenting1.96719100
19MP0002420_abnormal_adaptive_immunity1.96101934
20MP0002723_abnormal_immune_serum1.94606038
21MP0002148_abnormal_hypersensitivity_rea1.89655656
22MP0001819_abnormal_immune_cell1.89394366
23MP0005025_abnormal_response_to1.86624644
24MP0003724_increased_susceptibility_to1.81855749
25MP0003303_peritoneal_inflammation1.81373128
26MP0009697_abnormal_copulation1.77472073
27MP0000689_abnormal_spleen_morphology1.76606864
28MP0000716_abnormal_immune_system1.74326841
29MP0003866_abnormal_defecation1.73222047
30MP0001790_abnormal_immune_system1.68735694
31MP0005387_immune_system_phenotype1.68735694
32MP0002419_abnormal_innate_immunity1.65105421
33MP0002332_abnormal_exercise_endurance1.63141025
34MP0002722_abnormal_immune_system1.61522662
35MP0002429_abnormal_blood_cell1.56113890
36MP0002166_altered_tumor_susceptibility1.50971603
37MP0001845_abnormal_inflammatory_respons1.46615552
38MP0009763_increased_sensitivity_to1.42075348
39MP0002254_reproductive_system_inflammat1.38390216
40MP0001348_abnormal_lacrimal_gland1.38191052
41MP0002139_abnormal_hepatobiliary_system1.36094360
42MP0006036_abnormal_mitochondrial_physio1.30453978
43MP0010155_abnormal_intestine_physiology1.30287157
44MP0003300_gastrointestinal_ulcer1.28062486
45MP0001661_extended_life_span1.22997101
46MP0005448_abnormal_energy_balance1.22896964
47MP0003806_abnormal_nucleotide_metabolis1.22361670
48MP0005083_abnormal_biliary_tract1.20267506
49MP0005365_abnormal_bile_salt1.18660271
50MP0006082_CNS_inflammation1.17306887
51MP0003191_abnormal_cellular_cholesterol1.16584507
52MP0004381_abnormal_hair_follicle1.15691858
53MP0008058_abnormal_DNA_repair1.14228238
54MP0008004_abnormal_stomach_pH1.12795946
55MP0002006_tumorigenesis1.11517297
56MP0008469_abnormal_protein_level1.10219183
57MP0001851_eye_inflammation1.09297092
58MP0009765_abnormal_xenobiotic_induced1.07824842
59MP0002876_abnormal_thyroid_physiology1.05224815
60MP0005390_skeleton_phenotype1.03902103
61MP0004084_abnormal_cardiac_muscle1.03148725
62MP0003045_fibrosis1.01849044
63MP0008872_abnormal_physiological_respon1.00807434
64MP0005167_abnormal_blood-brain_barrier0.98965302
65MP0003646_muscle_fatigue0.93794471
66MP0001853_heart_inflammation0.91111905
67MP0002019_abnormal_tumor_incidence0.90298494
68MP0001663_abnormal_digestive_system0.87655466
69MP0005646_abnormal_pituitary_gland0.87231501
70MP0001765_abnormal_ion_homeostasis0.86654070
71MP0005310_abnormal_salivary_gland0.85894126
72MP0005075_abnormal_melanosome_morpholog0.80606248
73MP0004043_abnormal_pH_regulation0.80563152
74MP0002396_abnormal_hematopoietic_system0.80249226
75MP0000343_altered_response_to0.79072277
76MP0004036_abnormal_muscle_relaxation0.77941610
77MP0004947_skin_inflammation0.77730369
78MP0005084_abnormal_gallbladder_morpholo0.77379355
79MP0004130_abnormal_muscle_cell0.77131591
80MP0003868_abnormal_feces_composition0.75763819
81MP0006035_abnormal_mitochondrial_morpho0.75754473
82MP0002998_abnormal_bone_remodeling0.74324069
83MP0000609_abnormal_liver_physiology0.74145035
84MP0001873_stomach_inflammation0.72606220
85MP0000465_gastrointestinal_hemorrhage0.70388062
86MP0008775_abnormal_heart_ventricle0.68470991
87MP0000230_abnormal_systemic_arterial0.67134299
88MP0000598_abnormal_liver_morphology0.65441535
89MP0004142_abnormal_muscle_tone0.62907483
90MP0004510_myositis0.62033965
91MP0005647_abnormal_sex_gland0.61013876
92MP0001666_abnormal_nutrient_absorption0.60477714
93MP0005266_abnormal_metabolism0.59976717
94MP0003172_abnormal_lysosome_physiology0.57857848
95MP0001542_abnormal_bone_strength0.56154501
96MP0003638_abnormal_response/metabolism_0.55218553
97MP0010329_abnormal_lipoprotein_level0.54368311
98MP0010094_abnormal_chromosome_stability0.52362688
99MP0001944_abnormal_pancreas_morphology0.52288784
100MP0003786_premature_aging0.52228348

Predicted human phenotypes

RankGene SetZ-score
1Petechiae (HP:0000967)5.43170156
2Elevated erythrocyte sedimentation rate (HP:0003565)4.57476446
3Prolonged bleeding time (HP:0003010)3.96730369
4Severe combined immunodeficiency (HP:0004430)3.91175764
5Generalized aminoaciduria (HP:0002909)3.87275764
6IgG deficiency (HP:0004315)3.72318226
7Chronic mucocutaneous candidiasis (HP:0002728)3.69940181
8Recurrent cutaneous fungal infections (HP:0011370)3.69940181
9Purpura (HP:0000979)3.68581458
10Abnormal pupillary function (HP:0007686)3.67175662
11Reduced subcutaneous adipose tissue (HP:0003758)3.59300757
12Recurrent fungal infections (HP:0002841)3.57770791
13Stomatitis (HP:0010280)3.50485679
14Papilledema (HP:0001085)3.48759615
15Increased hepatocellular lipid droplets (HP:0006565)3.26292533
16Chronic hepatic failure (HP:0100626)3.20955695
17Panhypogammaglobulinemia (HP:0003139)3.10396107
18Combined immunodeficiency (HP:0005387)3.08672788
19T lymphocytopenia (HP:0005403)3.05651547
20Eosinophilia (HP:0001880)3.05440485
21Increased intramyocellular lipid droplets (HP:0012240)2.99525479
22Abnormality of eosinophils (HP:0001879)2.96857373
23Entropion (HP:0000621)2.93534347
24Renal Fanconi syndrome (HP:0001994)2.90621630
25B lymphocytopenia (HP:0010976)2.88408023
26Menorrhagia (HP:0000132)2.87899969
27Nausea (HP:0002018)2.87618214
28Paralysis (HP:0003470)2.85911076
29Thyroiditis (HP:0100646)2.85774920
30Epistaxis (HP:0000421)2.80402046
31Lipid accumulation in hepatocytes (HP:0006561)2.80384994
32Aplastic anemia (HP:0001915)2.72763837
33Exercise-induced myalgia (HP:0003738)2.70743720
34Recurrent bronchitis (HP:0002837)2.69654329
35Palpitations (HP:0001962)2.69180738
36Renal cortical cysts (HP:0000803)2.68821044
37Agammaglobulinemia (HP:0004432)2.67304545
38Granulocytopenia (HP:0001913)2.65461580
39Abnormality of T cell number (HP:0011839)2.63241873
40Type 2 muscle fiber atrophy (HP:0003554)2.63026653
41Abnormal platelet volume (HP:0011876)2.62693433
42Dyschromatopsia (HP:0007641)2.60399672
43Increased mean platelet volume (HP:0011877)2.60092328
44Recurrent viral infections (HP:0004429)2.58912445
45Lymphopenia (HP:0001888)2.56007143
46Acute encephalopathy (HP:0006846)2.55333101
47Increased muscle lipid content (HP:0009058)2.50438189
48Abnormality of B cell number (HP:0010975)2.49393381
49Encephalitis (HP:0002383)2.47396836
50Eczematoid dermatitis (HP:0000976)2.47191325
51Posterior subcapsular cataract (HP:0007787)2.46295890
52Glucose intolerance (HP:0000833)2.45629914
53Congenital, generalized hypertrichosis (HP:0004540)2.45011210
54Muscle fiber atrophy (HP:0100295)2.44883700
55Autoimmune hemolytic anemia (HP:0001890)2.42081387
56Leukocytosis (HP:0001974)2.39434875
57Gingival bleeding (HP:0000225)2.39196655
58Abnormality of T cells (HP:0002843)2.38788936
59Oral leukoplakia (HP:0002745)2.38667145
60Absent rod-and cone-mediated responses on ERG (HP:0007688)2.35622280
61Increased IgE level (HP:0003212)2.34680530
62IgM deficiency (HP:0002850)2.34449658
63Systemic lupus erythematosus (HP:0002725)2.28495379
64Lymphoma (HP:0002665)2.26762215
65Abnormal delayed hypersensitivity skin test (HP:0002963)2.24174566
66Exertional dyspnea (HP:0002875)2.22245286
67Nemaline bodies (HP:0003798)2.18907772
68Abnormality of cells of the lymphoid lineage (HP:0012140)2.18718561
69Chronic otitis media (HP:0000389)2.15814384
70Joint swelling (HP:0001386)2.12708622
71Abnormality of the heme biosynthetic pathway (HP:0010472)2.08417485
72Tinnitus (HP:0000360)2.06856621
73Abnormality of the fingertips (HP:0001211)2.03999056
74Increased IgM level (HP:0003496)2.03955648
75Muscle fiber inclusion bodies (HP:0100299)2.00270014
76Abnormal mitochondria in muscle tissue (HP:0008316)2.00252042
77Late onset (HP:0003584)1.99993571
78Submucous cleft hard palate (HP:0000176)1.99696530
79Rough bone trabeculation (HP:0100670)1.99598945
80Acute necrotizing encephalopathy (HP:0006965)1.98240877
81Limb hypertonia (HP:0002509)1.98104723
82Hypoglycemic coma (HP:0001325)1.98094056
83Abnormal spermatogenesis (HP:0008669)1.96902760
84Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.95495726
85Chorioretinal atrophy (HP:0000533)1.94399214
86Osteolytic defects of the phalanges of the hand (HP:0009771)1.94114131
87Osteolytic defects of the hand bones (HP:0009699)1.94114131
88Nasal polyposis (HP:0100582)1.93055147
89Cerebral hypomyelination (HP:0006808)1.92231138
90Acute hepatic failure (HP:0006554)1.91754576
91Neuroendocrine neoplasm (HP:0100634)1.90471426
92Mitochondrial inheritance (HP:0001427)1.87188733
93Verrucae (HP:0200043)1.86655154
94Papilloma (HP:0012740)1.86655154
95Keratoconjunctivitis (HP:0001096)1.85494914
96Chronic diarrhea (HP:0002028)1.85482119
97Pigmentary retinal degeneration (HP:0001146)1.84748199
98Hypoplasia of the thymus (HP:0000778)1.84298021
99Abnormality of methionine metabolism (HP:0010901)1.82595993
100Episodic fever (HP:0001954)1.82100071

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.51228927
2EIF2AK13.69587100
3NME23.63889956
4TXK3.28119543
5RIPK43.20486616
6MST42.85256761
7MAP4K12.79525311
8TNK22.44258252
9EIF2AK32.32529666
10KIT2.28845137
11GRK62.14641075
12IKBKB2.02711570
13NLK2.01655505
14SYK2.01170855
15SMG11.93867366
16ZAP701.93815359
17FES1.89206088
18TLK11.88959898
19BLK1.85815986
20TAOK31.79424659
21STK161.78902183
22BTK1.72243399
23ADRBK21.70614619
24WNK11.64213602
25VRK11.63794483
26CAMKK21.57098398
27WNK41.54284145
28IKBKE1.51229292
29MAP3K111.45775765
30BUB11.41363121
31PIK3CG1.40404737
32TYK21.35028401
33OBSCN1.31770536
34MAPKAPK31.30244048
35TEC1.26935879
36NEK61.24279798
37ITK1.24119665
38LYN1.18484328
39MAPK111.11210129
40TRIM281.10326592
41PHKG10.98785523
42PHKG20.98785523
43CSF1R0.97514371
44EIF2AK20.96872365
45PTK2B0.95965655
46JAK30.95711169
47MAP3K140.94665733
48HCK0.93717247
49LCK0.92976449
50MYLK0.91953572
51CSK0.91824374
52DAPK20.90562952
53CLK10.84765199
54IRAK40.79933652
55BMX0.75842492
56MAPK130.74503553
57PAK40.74009657
58KDR0.73741208
59NUAK10.73256260
60PBK0.73091984
61NME10.71015483
62PRKCQ0.70223579
63DAPK10.66521800
64SCYL20.62737349
65BCKDK0.60773215
66JAK10.59898898
67MAPK120.59850313
68MAP3K10.55392568
69TSSK60.54998419
70GRK50.54091519
71CDK70.52917601
72MAP3K120.52609656
73ACVR1B0.46968481
74MAP2K60.45297369
75IRAK30.42291584
76TESK20.41199048
77ABL20.39868909
78PLK10.38071203
79HIPK20.37731591
80IRAK10.37594733
81PRKCI0.37506713
82IGF1R0.37064058
83PDK10.36297832
84ILK0.36206664
85CAMKK10.36058235
86WNK30.33405018
87CAMK2A0.32488673
88JAK20.31423860
89STK40.30198822
90TTN0.29022893
91PIM20.28977306
92EPHA30.28529946
93CHUK0.28263020
94PAK10.27372736
95PRKG10.26813865
96FGR0.25162503
97DAPK30.24069590
98ALK0.23753209
99ADRBK10.23253024
100MELK0.21963712

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.43467869
2Primary immunodeficiency_Homo sapiens_hsa053405.43330738
3Type I diabetes mellitus_Homo sapiens_hsa049404.35314337
4Non-homologous end-joining_Homo sapiens_hsa034502.87588117
5SNARE interactions in vesicular transport_Homo sapiens_hsa041302.69863284
6NF-kappa B signaling pathway_Homo sapiens_hsa040642.64203735
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.55328732
8Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.18349360
9T cell receptor signaling pathway_Homo sapiens_hsa046602.17668216
10Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.16302354
11Antigen processing and presentation_Homo sapiens_hsa046122.08297493
12Hematopoietic cell lineage_Homo sapiens_hsa046402.05954935
13B cell receptor signaling pathway_Homo sapiens_hsa046621.79237246
14One carbon pool by folate_Homo sapiens_hsa006701.75089243
15Platelet activation_Homo sapiens_hsa046111.66831852
16Parkinsons disease_Homo sapiens_hsa050121.64328721
17Homologous recombination_Homo sapiens_hsa034401.60718084
18Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.54497672
19Autoimmune thyroid disease_Homo sapiens_hsa053201.53386327
20TNF signaling pathway_Homo sapiens_hsa046681.50702497
21Allograft rejection_Homo sapiens_hsa053301.49721029
22Measles_Homo sapiens_hsa051621.48338956
23Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.45113766
24Graft-versus-host disease_Homo sapiens_hsa053321.35266120
25Herpes simplex infection_Homo sapiens_hsa051681.34306221
26Oxidative phosphorylation_Homo sapiens_hsa001901.33662478
27Regulation of autophagy_Homo sapiens_hsa041401.33526718
28Intestinal immune network for IgA production_Homo sapiens_hsa046721.32100996
29Spliceosome_Homo sapiens_hsa030401.26998569
30alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.26017729
31Linoleic acid metabolism_Homo sapiens_hsa005911.21397935
32Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.20790205
33Viral myocarditis_Homo sapiens_hsa054161.19776548
34Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.15590537
35Jak-STAT signaling pathway_Homo sapiens_hsa046301.07039059
36Sulfur relay system_Homo sapiens_hsa041221.02575545
37mRNA surveillance pathway_Homo sapiens_hsa030151.02481613
38Osteoclast differentiation_Homo sapiens_hsa043800.99551863
39Asthma_Homo sapiens_hsa053100.98175923
40RNA degradation_Homo sapiens_hsa030180.97723423
41Ribosome_Homo sapiens_hsa030100.96792112
42RNA polymerase_Homo sapiens_hsa030200.92419548
43Epstein-Barr virus infection_Homo sapiens_hsa051690.90414615
44HTLV-I infection_Homo sapiens_hsa051660.90238675
45Leishmaniasis_Homo sapiens_hsa051400.89711987
46Chemokine signaling pathway_Homo sapiens_hsa040620.88018092
47Nitrogen metabolism_Homo sapiens_hsa009100.83491177
48Purine metabolism_Homo sapiens_hsa002300.76826549
49Tuberculosis_Homo sapiens_hsa051520.76408616
50Arachidonic acid metabolism_Homo sapiens_hsa005900.76038048
51Staphylococcus aureus infection_Homo sapiens_hsa051500.72618993
52Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.72538848
53Pyrimidine metabolism_Homo sapiens_hsa002400.70721968
54NOD-like receptor signaling pathway_Homo sapiens_hsa046210.69014256
55Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.68894153
56Nucleotide excision repair_Homo sapiens_hsa034200.67853852
57Collecting duct acid secretion_Homo sapiens_hsa049660.67162868
58Alzheimers disease_Homo sapiens_hsa050100.66262188
59Huntingtons disease_Homo sapiens_hsa050160.63969922
60Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.63453633
61RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.56940991
62Toxoplasmosis_Homo sapiens_hsa051450.55497256
63Malaria_Homo sapiens_hsa051440.55347352
64Fanconi anemia pathway_Homo sapiens_hsa034600.53128822
65Shigellosis_Homo sapiens_hsa051310.52833059
66Rheumatoid arthritis_Homo sapiens_hsa053230.50663579
67Mismatch repair_Homo sapiens_hsa034300.50553290
68Legionellosis_Homo sapiens_hsa051340.48309607
69Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.43113425
70Glycerophospholipid metabolism_Homo sapiens_hsa005640.41629602
71Folate biosynthesis_Homo sapiens_hsa007900.40930060
72Toll-like receptor signaling pathway_Homo sapiens_hsa046200.40189129
73Acute myeloid leukemia_Homo sapiens_hsa052210.38983992
74Insulin resistance_Homo sapiens_hsa049310.38810061
75Ether lipid metabolism_Homo sapiens_hsa005650.38309119
76Calcium signaling pathway_Homo sapiens_hsa040200.37742343
77Cysteine and methionine metabolism_Homo sapiens_hsa002700.36254294
78Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.32180984
79Fat digestion and absorption_Homo sapiens_hsa049750.32058148
80VEGF signaling pathway_Homo sapiens_hsa043700.31308369
81Propanoate metabolism_Homo sapiens_hsa006400.30633203
82Phagosome_Homo sapiens_hsa041450.30449532
83Leukocyte transendothelial migration_Homo sapiens_hsa046700.30062396
84Caffeine metabolism_Homo sapiens_hsa002320.29591371
85Glycerolipid metabolism_Homo sapiens_hsa005610.29483794
86beta-Alanine metabolism_Homo sapiens_hsa004100.28852548
87Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.25708082
88Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.25268930
89Influenza A_Homo sapiens_hsa051640.25025862
90Cardiac muscle contraction_Homo sapiens_hsa042600.24689887
91Apoptosis_Homo sapiens_hsa042100.22695459
92Endocytosis_Homo sapiens_hsa041440.22202938
93Choline metabolism in cancer_Homo sapiens_hsa052310.22058698
94Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.21901741
95Basal transcription factors_Homo sapiens_hsa030220.20847811
96Phototransduction_Homo sapiens_hsa047440.20320924
97Pancreatic secretion_Homo sapiens_hsa049720.20138478
98Viral carcinogenesis_Homo sapiens_hsa052030.19570496
99mTOR signaling pathway_Homo sapiens_hsa041500.18363995
100Hepatitis B_Homo sapiens_hsa051610.18011409

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