TRBV26

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of thymocyte apoptotic process (GO:0070243)8.85806284
2positive regulation of gamma-delta T cell activation (GO:0046645)8.85462853
3mucosal-associated lymphoid tissue development (GO:0048537)8.74115974
4Peyers patch development (GO:0048541)8.74115974
5activated T cell proliferation (GO:0050798)8.04249762
6positive T cell selection (GO:0043368)7.88293044
7negative regulation of T cell apoptotic process (GO:0070233)7.50330960
8T cell selection (GO:0045058)7.07058833
9positive regulation of interleukin-2 biosynthetic process (GO:0045086)6.96091673
10positive regulation of calcium-mediated signaling (GO:0050850)6.91891140
11modulation by virus of host process (GO:0019054)6.81733866
12T cell receptor signaling pathway (GO:0050852)6.78709181
13positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)6.66427820
14genitalia morphogenesis (GO:0035112)6.53547692
15regulation of regulatory T cell differentiation (GO:0045589)6.52607490
16somatic cell DNA recombination (GO:0016444)6.47169449
17somatic diversification of immune receptors via germline recombination within a single locus (GO:0006.47169449
18negative T cell selection (GO:0043383)6.41424352
19T cell differentiation in thymus (GO:0033077)6.38552591
20cellular hyperosmotic response (GO:0071474)6.07421890
21T cell differentiation (GO:0030217)6.03580197
22positive regulation of interleukin-2 production (GO:0032743)5.86070911
23somatic diversification of immune receptors (GO:0002200)5.82808790
24modulation by symbiont of host cellular process (GO:0044068)5.65365780
25alpha-beta T cell differentiation (GO:0046632)5.47847211
26T cell costimulation (GO:0031295)5.34777027
27T cell mediated immunity (GO:0002456)5.26465685
28lymphocyte costimulation (GO:0031294)5.23003998
29antigen receptor-mediated signaling pathway (GO:0050851)5.14447567
30mast cell activation involved in immune response (GO:0002279)5.07399974
31mast cell degranulation (GO:0043303)5.07399974
32negative regulation of lymphocyte apoptotic process (GO:0070229)5.07320207
33alpha-beta T cell activation (GO:0046631)5.02140266
34regulation of defense response to virus by virus (GO:0050690)4.91765199
35regulation of calcium-mediated signaling (GO:0050848)4.68971898
36regulation of interleukin-2 production (GO:0032663)4.56806651
37regulation of interleukin-2 biosynthetic process (GO:0045076)4.56525573
38mast cell activation (GO:0045576)4.46389048
39generation of neurons (GO:0048699)4.31430143
40regulation of T cell receptor signaling pathway (GO:0050856)4.30208195
41regulation of T cell apoptotic process (GO:0070232)4.27183991
42T cell lineage commitment (GO:0002360)4.26081691
43CD4-positive, alpha-beta T cell differentiation (GO:0043367)4.14498548
44negative regulation of erythrocyte differentiation (GO:0045647)4.00040465
45T cell activation (GO:0042110)3.97590423
46positive regulation of uterine smooth muscle contraction (GO:0070474)3.91990227
47T cell homeostasis (GO:0043029)3.88826085
48zinc ion homeostasis (GO:0055069)3.84249866
49lymphocyte differentiation (GO:0030098)3.76351482
50positive thymic T cell selection (GO:0045059)3.72948404
51positive regulation of histone H3-K4 methylation (GO:0051571)3.72710889
52CD4-positive, alpha-beta T cell activation (GO:0035710)3.70200873
53entry into other organism involved in symbiotic interaction (GO:0051828)3.69827502
54movement in host environment (GO:0052126)3.69827502
55entry into host cell (GO:0030260)3.69827502
56movement in environment of other organism involved in symbiotic interaction (GO:0052192)3.69827502
57entry into cell of other organism involved in symbiotic interaction (GO:0051806)3.69827502
58entry into host (GO:0044409)3.69827502
59negative regulation of leukocyte apoptotic process (GO:2000107)3.63443759
60histone H3-K9 demethylation (GO:0033169)3.58181618
61histone monoubiquitination (GO:0010390)3.57837910
62cellular zinc ion homeostasis (GO:0006882)3.55290004
63thymus development (GO:0048538)3.54059598
64histone H4 deacetylation (GO:0070933)3.48927185
65regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.48021279
66histone H3-K4 trimethylation (GO:0080182)3.39798454
67modulation by virus of host morphology or physiology (GO:0019048)3.39729673
68regulation of T cell differentiation (GO:0045580)3.39247541
69immune response-activating cell surface receptor signaling pathway (GO:0002429)3.39211328
70cellular response to sterol (GO:0036315)3.37489884
71negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.35199456
72negative regulation of cell killing (GO:0031342)3.35199456
73cellular response to osmotic stress (GO:0071470)3.31713659
74positive regulation of histone deacetylation (GO:0031065)3.29304156
75lymphocyte homeostasis (GO:0002260)3.22247196
76negative thymic T cell selection (GO:0045060)3.21709771
77T-helper cell differentiation (GO:0042093)3.20479287
78CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.20479287
79neurotransmitter catabolic process (GO:0042135)3.19153663
80lymph node development (GO:0048535)3.15545156
81regulation of histone H3-K4 methylation (GO:0051569)3.13080232
82regulation of uterine smooth muscle contraction (GO:0070472)3.11216950
83positive regulation of circadian rhythm (GO:0042753)3.10206749
84establishment of integrated proviral latency (GO:0075713)3.02144305
85thymic T cell selection (GO:0045061)3.00359655
86positive regulation of T cell activation (GO:0050870)2.98869770
87positive regulation of T cell differentiation (GO:0045582)2.98277738
88positive regulation of gene expression, epigenetic (GO:0045815)2.97219421
89regulation of T cell activation (GO:0050863)2.94079123
90DNA ligation (GO:0006266)2.89658535
91regulation of chromatin silencing (GO:0031935)2.83679980
92interferon-gamma production (GO:0032609)2.83128378
93regulation of lymphocyte apoptotic process (GO:0070228)2.81514863
94leukocyte homeostasis (GO:0001776)2.80043798
95positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.76877561
96peptidyl-lysine dimethylation (GO:0018027)2.74298372
97negative regulation of thymocyte apoptotic process (GO:0070244)15.7840530
98V(D)J recombination (GO:0033151)14.2840433
99regulation of gamma-delta T cell differentiation (GO:0045586)12.6110139
100regulation of gamma-delta T cell activation (GO:0046643)11.3099179

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EGR1_19374776_ChIP-ChIP_THP-1_Human6.78575888
2E2F7_22180533_ChIP-Seq_HELA_Human5.58088074
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.51112120
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.59524812
5MYC_22102868_ChIP-Seq_BL_Human4.58356854
6RUNX_20019798_ChIP-Seq_JUKART_Human4.01801130
7FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.65751015
8MYB_26560356_Chip-Seq_TH2_Human3.50040173
9FOXM1_23109430_ChIP-Seq_U2OS_Human3.37009832
10UTX_26944678_Chip-Seq_JUKART_Human3.35589276
11TCF7_22412390_ChIP-Seq_EML_Mouse3.21132186
12GATA3_27048872_Chip-Seq_THYMUS_Human3.18747727
13KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.99882870
14VDR_21846776_ChIP-Seq_THP-1_Human2.88386012
15KDM2B_26808549_Chip-Seq_DND41_Human2.81730607
16NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.68346197
17MAF_26560356_Chip-Seq_TH1_Human2.59053197
18SCL_19346495_ChIP-Seq_HPC-7_Human2.48790158
19E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.33358762
20MYB_26560356_Chip-Seq_TH1_Human2.27150691
21KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.23032449
22HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.18978640
23FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.18857880
24MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.15464776
25VDR_24763502_ChIP-Seq_THP-1_Human2.09813176
26STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.05053676
27DNAJC2_21179169_ChIP-ChIP_NT2_Human2.00378915
28CIITA_25753668_ChIP-Seq_RAJI_Human1.91163254
29RUNX1_22412390_ChIP-Seq_EML_Mouse1.82318142
30KDM2B_26808549_Chip-Seq_SUP-B15_Human1.80920131
31TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.68357552
32RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.61396899
33RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.60014211
34KDM2B_26808549_Chip-Seq_JURKAT_Human1.59161108
35MAF_26560356_Chip-Seq_TH2_Human1.56690286
36ELK3_25401928_ChIP-Seq_HUVEC_Human1.53329847
37FOXO3_23340844_ChIP-Seq_DLD1_Human1.49342221
38TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.45332502
39RUNX1_27514584_Chip-Seq_MCF-7_Human1.44320205
40SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.35884273
41ZFP281_27345836_Chip-Seq_ESCs_Mouse1.33514152
42WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.29556818
43SPI1_23127762_ChIP-Seq_K562_Human1.28340122
44NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.26910194
45E2F4_17652178_ChIP-ChIP_JURKAT_Human1.26887938
46TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.26669203
47GATA2_22383799_ChIP-Seq_G1ME_Mouse1.25414179
48DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.19868776
49ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.16522647
50GATA2_19941826_ChIP-Seq_K562_Human1.10645802
51EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.10468200
52MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.09706260
53CLOCK_20551151_ChIP-Seq_293T_Human1.07919238
54ZFP281_18757296_ChIP-ChIP_E14_Mouse1.07262235
55KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.05842251
56TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.03679538
57TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.02940218
58RARB_27405468_Chip-Seq_BRAIN_Mouse1.00462153
59KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.99673090
60VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.99588512
61RACK7_27058665_Chip-Seq_MCF-7_Human0.99364589
62GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99236300
63BRD4_27068464_Chip-Seq_AML-cells_Mouse0.99137886
64GATA1_19941826_ChIP-Seq_K562_Human0.98911224
65FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.98882347
66IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.98878566
67SMAD_19615063_ChIP-ChIP_OVARY_Human0.98482892
68LXR_22292898_ChIP-Seq_THP-1_Human0.98238324
69NCOR1_26117541_ChIP-Seq_K562_Human0.96222068
70PKCTHETA_26484144_Chip-Seq_BREAST_Human0.95497498
71SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.95461685
72SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.94668530
73ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.93275219
74ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.92987465
75IRF8_27001747_Chip-Seq_BMDM_Mouse0.92018755
76KDM2B_26808549_Chip-Seq_K562_Human0.91840354
77MYB_21317192_ChIP-Seq_ERMYB_Mouse0.90162279
78EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.88583710
79STAT4_19710469_ChIP-ChIP_TH1__Mouse0.88143977
80GATA3_26560356_Chip-Seq_TH2_Human0.87297364
81CTCF_21964334_ChIP-Seq_BJAB-B_Human0.86806584
82IRF8_22096565_ChIP-ChIP_GC-B_Human0.83414317
83ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.82482246
84CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.80944485
85LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.80605630
86GATA1_22383799_ChIP-Seq_G1ME_Mouse0.78835159
87TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.78769214
88SA1_27219007_Chip-Seq_ERYTHROID_Human0.78322294
89RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.78003562
90PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.77996591
91TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.77865670
92FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.75728509
93TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.75721741
94P300_27058665_Chip-Seq_ZR-75-30cells_Human0.75599559
95SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.75232295
96ETS1_22383799_ChIP-Seq_G1ME_Mouse0.74149115
97BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.73894823
98NANOG_21062744_ChIP-ChIP_HESCs_Human0.73617038
99PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.73065698
100ESR1_21235772_ChIP-Seq_MCF-7_Human0.72816248

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005409_darkened_coat_color5.63434842
2MP0003763_abnormal_thymus_physiology5.19998188
3MP0002132_abnormal_respiratory_system4.69889538
4MP0002166_altered_tumor_susceptibility4.64710620
5MP0001849_ear_inflammation4.18294372
6MP0005671_abnormal_response_to4.18238363
7MP0000703_abnormal_thymus_morphology3.98147330
8MP0009278_abnormal_bone_marrow3.73738867
9MP0002006_tumorigenesis3.45319237
10MP0004947_skin_inflammation3.22381971
11MP0010155_abnormal_intestine_physiology2.84003175
12MP0000015_abnormal_ear_pigmentation2.77235766
13MP0005365_abnormal_bile_salt2.75935191
14MP0005174_abnormal_tail_pigmentation2.73461288
15MP0006082_CNS_inflammation2.51601592
16MP0009785_altered_susceptibility_to2.50877194
17MP0000685_abnormal_immune_system2.41704421
18MP0010094_abnormal_chromosome_stability2.38927447
19MP0002876_abnormal_thyroid_physiology2.34456786
20MP0002095_abnormal_skin_pigmentation2.32294527
21MP0004130_abnormal_muscle_cell2.20485481
22MP0001879_abnormal_lymphatic_vessel2.12503628
23MP0002398_abnormal_bone_marrow2.08463436
24MP0005397_hematopoietic_system_phenotyp2.01973407
25MP0001545_abnormal_hematopoietic_system2.01973407
26MP0002722_abnormal_immune_system1.98381273
27MP0000920_abnormal_myelination1.92578112
28MP0004808_abnormal_hematopoietic_stem1.79343689
29MP0002933_joint_inflammation1.69196362
30MP0000716_abnormal_immune_system1.60307419
31MP0001790_abnormal_immune_system1.58627634
32MP0005387_immune_system_phenotype1.58627634
33MP0003879_abnormal_hair_cell1.54146310
34MP0000689_abnormal_spleen_morphology1.52860232
35MP0002405_respiratory_system_inflammati1.51578643
36MP0000462_abnormal_digestive_system1.47223966
37MP0001835_abnormal_antigen_presentation1.44449009
38MP0003300_gastrointestinal_ulcer1.41188501
39MP0009333_abnormal_splenocyte_physiolog1.40258221
40MP0001800_abnormal_humoral_immune1.39697848
41MP0002075_abnormal_coat/hair_pigmentati1.36910126
42MP0002420_abnormal_adaptive_immunity1.32499932
43MP0001819_abnormal_immune_cell1.30111108
44MP0002723_abnormal_immune_serum1.25439148
45MP0005000_abnormal_immune_tolerance1.23504282
46MP0002429_abnormal_blood_cell1.19620952
47MP0006035_abnormal_mitochondrial_morpho1.14012936
48MP0003959_abnormal_lean_body1.10138070
49MP0005025_abnormal_response_to1.08067485
50MP0008961_abnormal_basal_metabolism1.07651061
51MP0001243_abnormal_dermal_layer1.07622292
52MP0008569_lethality_at_weaning1.04596359
53MP0001191_abnormal_skin_condition1.03440292
54MP0002971_abnormal_brown_adipose0.99065944
55MP0001186_pigmentation_phenotype0.95699573
56MP0005076_abnormal_cell_differentiation0.95289391
57MP0001845_abnormal_inflammatory_respons0.95013414
58MP0000383_abnormal_hair_follicle0.92385455
59MP0008770_decreased_survivor_rate0.90587738
60MP0000490_abnormal_crypts_of0.88464697
61MP0005464_abnormal_platelet_physiology0.86452185
62MP0003787_abnormal_imprinting0.83523157
63MP0002452_abnormal_antigen_presenting0.79409061
64MP0010678_abnormal_skin_adnexa0.78659140
65MP0000609_abnormal_liver_physiology0.74161272
66MP0004859_abnormal_synaptic_plasticity0.68350992
67MP0002019_abnormal_tumor_incidence0.68176251
68MP0002396_abnormal_hematopoietic_system0.67955756
69MP0002092_abnormal_eye_morphology0.66621286
70MP0002160_abnormal_reproductive_system0.65134946
71MP0002970_abnormal_white_adipose0.63477413
72MP0002148_abnormal_hypersensitivity_rea0.62216234
73MP0002083_premature_death0.60987581
74MP0002998_abnormal_bone_remodeling0.59231588
75MP0002127_abnormal_cardiovascular_syste0.56033489
76MP0002060_abnormal_skin_morphology0.55627826
77MP0010352_gastrointestinal_tract_polyps0.55197943
78MP0009115_abnormal_fat_cell0.53967293
79MP0005360_urolithiasis0.53625640
80MP0000367_abnormal_coat/_hair0.52696183
81MP0006054_spinal_hemorrhage0.52434553
82MP0005584_abnormal_enzyme/coenzyme_acti0.51347315
83MP0000477_abnormal_intestine_morphology0.50079655
84MP0005334_abnormal_fat_pad0.49276864
85MP0002009_preneoplasia0.47446665
86MP0002419_abnormal_innate_immunity0.47439299
87MP0001944_abnormal_pancreas_morphology0.41566974
88MP0001853_heart_inflammation0.40559714
89MP0003303_peritoneal_inflammation0.40292252
90MP0010234_abnormal_vibrissa_follicle0.38994408
91MP0003705_abnormal_hypodermis_morpholog0.37096201
92MP0000767_abnormal_smooth_muscle0.36939877
93MP0005535_abnormal_body_temperature0.36706259
94MP0001784_abnormal_fluid_regulation0.35665014
95MP0003635_abnormal_synaptic_transmissio0.35140768
96MP0002078_abnormal_glucose_homeostasis0.34637338
97MP0004197_abnormal_fetal_growth/weight/0.33944598
98MP0008874_decreased_physiological_sensi0.33437639
99MP0003866_abnormal_defecation0.32040265
100MP0010771_integument_phenotype0.31758564

Predicted human phenotypes

RankGene SetZ-score
1Severe combined immunodeficiency (HP:0004430)9.75933111
2Thyroiditis (HP:0100646)9.49208207
3Panhypogammaglobulinemia (HP:0003139)9.19135762
4Eosinophilia (HP:0001880)8.47836655
5Combined immunodeficiency (HP:0005387)8.37760849
6Hypoproteinemia (HP:0003075)7.55605619
7Recurrent viral infections (HP:0004429)7.48646110
8Granulocytopenia (HP:0001913)6.82560673
9Abnormality of eosinophils (HP:0001879)6.15593319
10Abnormality of T cells (HP:0002843)5.60990077
11Erythroderma (HP:0001019)5.48866630
12Leukocytosis (HP:0001974)4.40978974
13IgG deficiency (HP:0004315)4.26767152
14Recurrent fungal infections (HP:0002841)4.08747270
15Aplasia/Hypoplasia of the thymus (HP:0010515)3.37394826
16Abnormality of the thymus (HP:0000777)2.80970336
17Meningitis (HP:0001287)2.14012832
18Deep philtrum (HP:0002002)2.07246148
19T lymphocytopenia (HP:0005403)12.6232536
20Abnormality of T cell number (HP:0011839)11.9442229
21Abnormality of B cell number (HP:0010975)11.6564859
22B lymphocytopenia (HP:0010976)11.6564859
23Hypoplasia of the thymus (HP:0000778)11.1437956
24Cellular immunodeficiency (HP:0005374)1.99300992
25Abnormality of the fingertips (HP:0001211)1.97303907
26Sepsis (HP:0100806)1.96132339
27Volvulus (HP:0002580)1.89518802
28Bicuspid aortic valve (HP:0001647)1.87134696
29Lymphoma (HP:0002665)1.79823274
30Pustule (HP:0200039)1.79628563
31Acute lymphatic leukemia (HP:0006721)1.78039981
32Mitral regurgitation (HP:0001653)1.58764489
33Papilloma (HP:0012740)1.52097324
34Verrucae (HP:0200043)1.52097324
35Bronchiectasis (HP:0002110)1.51287692
36Hyperacusis (HP:0010780)1.46389222
37Macroorchidism (HP:0000053)1.45357226
38Supranuclear gaze palsy (HP:0000605)1.42680842
39Pruritus (HP:0000989)1.38626445
40Autoimmune thrombocytopenia (HP:0001973)1.34089493
41Basal cell carcinoma (HP:0002671)1.33269358
42Type 2 muscle fiber atrophy (HP:0003554)1.26901107
43Elevated erythrocyte sedimentation rate (HP:0003565)1.25804372
44Joint swelling (HP:0001386)1.23516708
45Aortic valve stenosis (HP:0001650)1.23006573
46Weak cry (HP:0001612)1.20253077
47Muscle fiber atrophy (HP:0100295)1.14226089
48Abnormal delayed hypersensitivity skin test (HP:0002963)1.12768876
49Wide intermamillary distance (HP:0006610)1.12685684
50Slow saccadic eye movements (HP:0000514)1.10169666
51Nephrotic syndrome (HP:0000100)1.09945830
52Abnormality of chromosome segregation (HP:0002916)1.08536822
53Chronic mucocutaneous candidiasis (HP:0002728)1.05543365
54Recurrent cutaneous fungal infections (HP:0011370)1.05543365
55Heterotopia (HP:0002282)1.02332264
56Sparse lateral eyebrow (HP:0005338)1.01950357
57Hypothyroidism (HP:0000821)0.98877515
58Broad palm (HP:0001169)0.96102741
59Decreased muscle mass (HP:0003199)0.95251593
60Increased nuchal translucency (HP:0010880)0.93315592
61Dry skin (HP:0000958)0.93004709
62Seborrheic dermatitis (HP:0001051)0.91228565
63Abnormality of the neuromuscular junction (HP:0003398)0.90967821
64Fatigable weakness (HP:0003473)0.90967821
65Cutis marmorata (HP:0000965)0.90485475
66Encephalitis (HP:0002383)0.89910499
67Abnormality of proline metabolism (HP:0010907)0.88708386
68Hydroxyprolinuria (HP:0003080)0.88708386
69Inappropriate behavior (HP:0000719)0.86685031
70Long eyelashes (HP:0000527)0.85058784
71Pseudobulbar signs (HP:0002200)0.84854530
72Generalized hypotonia (HP:0001290)0.84025859
73Spontaneous hematomas (HP:0007420)0.83575961
74Hypochromic anemia (HP:0001931)0.80703885
75Easy fatigability (HP:0003388)0.80189142
76Obsessive-compulsive behavior (HP:0000722)0.79233600
77Disinhibition (HP:0000734)0.79179027
78Abnormality of the pancreatic islet cells (HP:0006476)0.79131302
79Abnormality of endocrine pancreas physiology (HP:0012093)0.79131302
80Premature skin wrinkling (HP:0100678)0.78915153
81Abnormality of oral frenula (HP:0000190)0.78507512
82Increased IgM level (HP:0003496)0.74354556
83Prolonged bleeding time (HP:0003010)0.74225598
84Abnormal platelet volume (HP:0011876)0.73391544
85Tented upper lip vermilion (HP:0010804)0.73263353
86Hypochromic microcytic anemia (HP:0004840)0.71773126
87Proximal placement of thumb (HP:0009623)0.71754533
88Autoimmune hemolytic anemia (HP:0001890)0.70565906
89Vertebral arch anomaly (HP:0008438)0.70353516
90Elfin facies (HP:0004428)0.70267029
91Muscle stiffness (HP:0003552)0.69934524
92Hepatitis (HP:0012115)0.68557562
93Sacral dimple (HP:0000960)0.68473286
94Pancreatic islet-cell hyperplasia (HP:0004510)0.67852446
95Deep venous thrombosis (HP:0002625)0.67805637
96Abnormal foot bone ossification (HP:0010675)0.66721656
97Stomatitis (HP:0010280)0.66589595
98Truncal obesity (HP:0001956)0.66108683
99Recurrent skin infections (HP:0001581)0.65292006
100Chronic otitis media (HP:0000389)0.65099511

Predicted kinase interactions (KEA)

RankGene SetZ-score
1YES14.83984148
2PDGFRB3.84198755
3ZAP703.61374522
4MAP3K73.40435306
5MAP4K13.09856013
6GRK62.77557676
7SYK2.75128480
8SIK22.61757398
9TXK2.47671318
10MST42.36014663
11MARK22.30110667
12MAPK72.26595340
13ITK2.25844972
14CSNK1A1L2.17616465
15CSK2.13707940
16FGFR22.11769548
17CDK121.97835559
18MAP3K101.94828494
19PKN21.88407720
20CSNK1G31.69799057
21CAMKK21.68429729
22PRKCQ1.66886242
23CSNK1G21.59720151
24HCK1.59069414
25MAPK41.57346395
26NTRK21.52963854
27LCK1.51878610
28CAMK11.51502543
29FGFR41.46967224
30CDK61.45509975
31RIPK41.41705644
32PTK61.40544668
33STK101.31620960
34BRD41.25943070
35CSNK1G11.19624210
36FGFR31.18266350
37TYK21.18115139
38MAPK121.17289521
39TRIB31.15832313
40PRKCH1.13954021
41CAMKK11.13918639
42NEK21.10998813
43PRKD11.09242802
44INSR1.02912447
45HIPK20.98160669
46RPS6KB20.92216489
47DYRK1B0.92092773
48CDK30.91200053
49LRRK20.90520851
50UHMK10.89446894
51TYRO30.88917301
52MKNK20.88425981
53CLK10.87952004
54FYN0.80714950
55JAK20.76718441
56SIK10.69619644
57MAP3K10.69497918
58RET0.69360584
59STK40.64804502
60CDC70.61230526
61CDK40.59864553
62EPHB10.58523732
63PRKDC0.55947960
64PDGFRA0.53837599
65ALK0.51722558
66ERBB30.50613528
67CAMK40.49850947
68MAPK30.49778282
69MAPK110.48036983
70BTK0.47759415
71MAP3K130.47644419
72EGFR0.46334934
73MAPK90.45425256
74CSNK1D0.44454448
75PAK30.44239558
76TEC0.42184705
77MAPK80.41262244
78ATM0.39562091
79FGFR10.38763128
80CHEK10.38116746
81PRKD20.37910314
82ABL10.37585552
83SRC0.36539046
84SGK30.34741365
85ERN10.34112908
86TTN0.32780423
87EEF2K0.32099118
88DAPK20.30983182
89MKNK10.30542915
90MAP3K20.28488746
91TESK20.26208613
92GSK3B0.25617669
93MAPK140.25590739
94CDK20.24202870
95MAPKAPK20.23937299
96ATR0.23657217
97TNK20.23182803
98MAPK10.22426699
99FES0.21533284
100MAP3K80.21235317

Predicted pathways (KEGG)

RankGene SetZ-score
1T cell receptor signaling pathway_Homo sapiens_hsa046604.97476166
2Non-homologous end-joining_Homo sapiens_hsa034504.06287356
3Antigen processing and presentation_Homo sapiens_hsa046123.64988033
4Hematopoietic cell lineage_Homo sapiens_hsa046402.61218171
5Intestinal immune network for IgA production_Homo sapiens_hsa046722.30627237
6Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.15914013
7Primary immunodeficiency_Homo sapiens_hsa0534010.5523242
8Thyroid cancer_Homo sapiens_hsa052161.86941643
9Circadian rhythm_Homo sapiens_hsa047101.52845448
10Chronic myeloid leukemia_Homo sapiens_hsa052201.52600053
11Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.45514285
12Acute myeloid leukemia_Homo sapiens_hsa052211.42006821
13Lysine degradation_Homo sapiens_hsa003101.41095036
14FoxO signaling pathway_Homo sapiens_hsa040681.26856915
15Endometrial cancer_Homo sapiens_hsa052131.26369195
16Colorectal cancer_Homo sapiens_hsa052101.14978628
17Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.14882864
18Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.11490528
19NF-kappa B signaling pathway_Homo sapiens_hsa040641.11456591
20Dorso-ventral axis formation_Homo sapiens_hsa043201.08629347
21Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.04292669
22Leukocyte transendothelial migration_Homo sapiens_hsa046701.04031077
23ErbB signaling pathway_Homo sapiens_hsa040121.00603209
24Chemokine signaling pathway_Homo sapiens_hsa040620.96550976
25Phosphatidylinositol signaling system_Homo sapiens_hsa040700.95058532
26Non-small cell lung cancer_Homo sapiens_hsa052230.94362635
27Prostate cancer_Homo sapiens_hsa052150.90143027
28Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.88085991
29Long-term potentiation_Homo sapiens_hsa047200.82515202
30HTLV-I infection_Homo sapiens_hsa051660.82057674
31Osteoclast differentiation_Homo sapiens_hsa043800.81175482
32B cell receptor signaling pathway_Homo sapiens_hsa046620.73723347
33Choline metabolism in cancer_Homo sapiens_hsa052310.69191382
34Platelet activation_Homo sapiens_hsa046110.68295960
35Melanogenesis_Homo sapiens_hsa049160.66447463
36Aldosterone synthesis and secretion_Homo sapiens_hsa049250.64444141
37Basal cell carcinoma_Homo sapiens_hsa052170.63345697
38Glycerolipid metabolism_Homo sapiens_hsa005610.61752313
39Hepatitis B_Homo sapiens_hsa051610.60904348
40Gastric acid secretion_Homo sapiens_hsa049710.56442020
41Measles_Homo sapiens_hsa051620.55215341
42Phospholipase D signaling pathway_Homo sapiens_hsa040720.54195446
43Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.54124273
44Estrogen signaling pathway_Homo sapiens_hsa049150.51850878
45Glioma_Homo sapiens_hsa052140.51010414
46Adherens junction_Homo sapiens_hsa045200.50995113
47Rap1 signaling pathway_Homo sapiens_hsa040150.47601290
48Insulin resistance_Homo sapiens_hsa049310.46867402
49MicroRNAs in cancer_Homo sapiens_hsa052060.46056703
50Renin secretion_Homo sapiens_hsa049240.45815730
51Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.44111379
52mRNA surveillance pathway_Homo sapiens_hsa030150.43444115
53Spliceosome_Homo sapiens_hsa030400.43197560
54Proteoglycans in cancer_Homo sapiens_hsa052050.42626933
55mTOR signaling pathway_Homo sapiens_hsa041500.42175188
56Staphylococcus aureus infection_Homo sapiens_hsa051500.41554971
57Wnt signaling pathway_Homo sapiens_hsa043100.40929159
58Oxytocin signaling pathway_Homo sapiens_hsa049210.39680928
59Pancreatic cancer_Homo sapiens_hsa052120.39417322
60Pathways in cancer_Homo sapiens_hsa052000.38894614
61Viral carcinogenesis_Homo sapiens_hsa052030.38758101
62Nitrogen metabolism_Homo sapiens_hsa009100.38694337
63Insulin signaling pathway_Homo sapiens_hsa049100.38674154
64Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.38429243
65Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.37448463
66Cholinergic synapse_Homo sapiens_hsa047250.37208463
67Viral myocarditis_Homo sapiens_hsa054160.36767590
68Salivary secretion_Homo sapiens_hsa049700.33873120
69Ras signaling pathway_Homo sapiens_hsa040140.30731484
70Neurotrophin signaling pathway_Homo sapiens_hsa047220.30731012
71cGMP-PKG signaling pathway_Homo sapiens_hsa040220.30449197
72Type II diabetes mellitus_Homo sapiens_hsa049300.30439324
73Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.28273542
74Small cell lung cancer_Homo sapiens_hsa052220.27017331
75Primary bile acid biosynthesis_Homo sapiens_hsa001200.26781510
76Glutamatergic synapse_Homo sapiens_hsa047240.26118865
77VEGF signaling pathway_Homo sapiens_hsa043700.26058223
78Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.25068159
79Cell cycle_Homo sapiens_hsa041100.25051927
80Herpes simplex infection_Homo sapiens_hsa051680.24951237
81Thyroid hormone signaling pathway_Homo sapiens_hsa049190.23529384
82ABC transporters_Homo sapiens_hsa020100.23158095
83Dopaminergic synapse_Homo sapiens_hsa047280.22921437
84Thyroid hormone synthesis_Homo sapiens_hsa049180.22442749
85Renal cell carcinoma_Homo sapiens_hsa052110.22133374
86GnRH signaling pathway_Homo sapiens_hsa049120.21380733
87Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.20219469
88Endocytosis_Homo sapiens_hsa041440.20054362
89Gap junction_Homo sapiens_hsa045400.19706623
90Vascular smooth muscle contraction_Homo sapiens_hsa042700.19678470
91Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.19294131
92Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.19289767
93MAPK signaling pathway_Homo sapiens_hsa040100.19002672
94AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.18949262
95Amphetamine addiction_Homo sapiens_hsa050310.18332455
96Leishmaniasis_Homo sapiens_hsa051400.16402163
97Bile secretion_Homo sapiens_hsa049760.15395630
98Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.15344467
99Oocyte meiosis_Homo sapiens_hsa041140.14956535
100Axon guidance_Homo sapiens_hsa043600.14931982

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