ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	gamma-aminobutyric acid transport (GO:0015812)	5.33389870
2	negative regulation of synaptic transmission, glutamatergic (GO:0051967)	5.14677049
3	pyrimidine nucleobase catabolic process (GO:0006208)	5.13025741
4	DNA integration (GO:0015074)	5.07764393
5	neuron cell-cell adhesion (GO:0007158)	4.63163089
6	auditory behavior (GO:0031223)	4.58630831
7	sequestering of actin monomers (GO:0042989)	4.38250571
8	DNA double-strand break processing (GO:0000729)	4.35368475
9	establishment of mitochondrion localization (GO:0051654)	4.14105003
10	negative regulation of synaptic transmission, GABAergic (GO:0032229)	4.07983111
11	nucleobase catabolic process (GO:0046113)	4.06521204
12	positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902110	3.85606765
13	mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)	3.85606765
14	vocalization behavior (GO:0071625)	3.84616133
15	synaptic vesicle endocytosis (GO:0048488)	3.83251098
16	response to pheromone (GO:0019236)	3.81151986
17	postsynaptic membrane organization (GO:0001941)	3.79813824
18	dendritic spine morphogenesis (GO:0060997)	3.78016174
19	synapse assembly (GO:0007416)	3.71662398
20	retinal ganglion cell axon guidance (GO:0031290)	3.67618536
21	epithelial cilium movement (GO:0003351)	3.50364227
22	regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)	3.49047461
23	negative regulation of mast cell activation (GO:0033004)	3.48907668
24	response to histamine (GO:0034776)	3.47646565
25	mechanosensory behavior (GO:0007638)	3.45693960
26	startle response (GO:0001964)	3.42010964
27	negative regulation of oligodendrocyte differentiation (GO:0048715)	3.40274920
28	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)	3.32279237
29	protein localization to synapse (GO:0035418)	3.29922948
30	behavioral response to nicotine (GO:0035095)	3.27432292
31	positive regulation of mitochondrial fission (GO:0090141)	3.26175795
32	peptidyl-arginine N-methylation (GO:0035246)	3.24456150
33	peptidyl-arginine methylation (GO:0018216)	3.24456150
34	presynaptic membrane assembly (GO:0097105)	3.21113927
35	innervation (GO:0060384)	3.16739253
36	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	3.15675944
37	transmission of nerve impulse (GO:0019226)	3.14347967
38	nonmotile primary cilium assembly (GO:0035058)	3.12801740
39	dendritic spine organization (GO:0097061)	3.12615007
40	ribonucleoprotein complex disassembly (GO:0032988)	3.11373330
41	inner ear receptor cell development (GO:0060119)	3.07132146
42	C4-dicarboxylate transport (GO:0015740)	3.04875605
43	olfactory bulb development (GO:0021772)	3.04247956
44	head development (GO:0060322)	3.00005201
45	positive regulation of synapse assembly (GO:0051965)	2.97900526
46	hippocampus development (GO:0021766)	2.97459373
47	organelle transport along microtubule (GO:0072384)	2.96569027
48	synaptic vesicle maturation (GO:0016188)	2.95097841
49	histone H2A acetylation (GO:0043968)	2.94382592
50	reflex (GO:0060004)	2.93739786
51	neural tube formation (GO:0001841)	2.91609272
52	response to auditory stimulus (GO:0010996)	2.89982311
53	neuronal ion channel clustering (GO:0045161)	2.89182348
54	cerebral cortex radially oriented cell migration (GO:0021799)	2.87982405
55	negative regulation of microtubule polymerization (GO:0031115)	2.87957064
56	synaptic vesicle exocytosis (GO:0016079)	2.85349495
57	neurotransmitter-gated ion channel clustering (GO:0072578)	2.84113223
58	vesicle transport along microtubule (GO:0047496)	2.81575083
59	cilium or flagellum-dependent cell motility (GO:0001539)	2.80415493
60	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.79165512
61	regulation of alternative mRNA splicing, via spliceosome (GO:0000381)	2.77854564
62	positive regulation of RNA splicing (GO:0033120)	2.77699898
63	protein polyglutamylation (GO:0018095)	2.77434043
64	protein localization to cilium (GO:0061512)	2.76866095
65	establishment of vesicle localization (GO:0051650)	2.76667175
66	acidic amino acid transport (GO:0015800)	2.74862944
67	gamma-aminobutyric acid signaling pathway (GO:0007214)	2.74299651
68	regulation of respiratory gaseous exchange by neurological system process (GO:0002087)	2.74226670
69	pyrimidine dimer repair (GO:0006290)	2.73761929
70	magnesium ion transport (GO:0015693)	2.72086270
71	neuronal action potential propagation (GO:0019227)	2.71901527
72	vesicle localization (GO:0051648)	2.70406139
73	regulation of cilium movement (GO:0003352)	2.69782173
74	neurotransmitter uptake (GO:0001504)	2.69374368
75	short-term memory (GO:0007614)	2.68865506
76	positive regulation of excitatory postsynaptic membrane potential (GO:2000463)	2.68207573
77	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.68050179
78	cilium movement (GO:0003341)	2.67282561
79	regulation of synaptic transmission, glutamatergic (GO:0051966)	2.67094901
80	cornea development in camera-type eye (GO:0061303)	2.65834452
81	ubiquinone metabolic process (GO:0006743)	2.64596332
82	axonal fasciculation (GO:0007413)	2.63979766
83	sympathetic nervous system development (GO:0048485)	2.63084171
84	glycerophospholipid catabolic process (GO:0046475)	2.62478892
85	membrane budding (GO:0006900)	2.60762199
86	presynaptic membrane organization (GO:0097090)	2.60395112
87	melanosome transport (GO:0032402)	2.59763615
88	mitochondrion transport along microtubule (GO:0047497)	2.59577464
89	establishment of mitochondrion localization, microtubule-mediated (GO:0034643)	2.59577464
90	establishment of melanosome localization (GO:0032401)	2.58269602
91	positive regulation of dendritic spine morphogenesis (GO:0061003)	2.58022215
92	L-fucose catabolic process (GO:0042355)	2.57970889
93	fucose catabolic process (GO:0019317)	2.57970889
94	L-fucose metabolic process (GO:0042354)	2.57970889
95	central nervous system projection neuron axonogenesis (GO:0021952)	2.56546324
96	regulation of development, heterochronic (GO:0040034)	2.54671832
97	L-glutamate transport (GO:0015813)	2.50911512
98	synapse organization (GO:0050808)	2.50465733
99	cochlea development (GO:0090102)	2.48172408
100	establishment of nucleus localization (GO:0040023)	2.47529039

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	IGF1R_20145208_ChIP-Seq_DFB_Human	4.58714439
2	GBX2_23144817_ChIP-Seq_PC3_Human	4.08018988
3	ZNF274_21170338_ChIP-Seq_K562_Hela	3.96558111
4	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.91556439
5	POU3F2_20337985_ChIP-ChIP_501MEL_Human	3.22238383
6	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.99656479
7	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.82608913
8	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.80080361
9	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.67598782
10	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.58912831
11	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.46345964
12	EZH2_22144423_ChIP-Seq_EOC_Human	2.35766985
13	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.35543714
14	VDR_22108803_ChIP-Seq_LS180_Human	2.16332329
15	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	2.11534627
16	TAF15_26573619_Chip-Seq_HEK293_Human	2.10365990
17	FUS_26573619_Chip-Seq_HEK293_Human	2.09320741
18	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.07256742
19	EWS_26573619_Chip-Seq_HEK293_Human	2.03399267
20	P300_19829295_ChIP-Seq_ESCs_Human	1.86455508
21	RNF2_27304074_Chip-Seq_NSC_Mouse	1.80971824
22	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.79686480
23	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.72565784
24	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.71024710
25	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.67411827
26	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.64519263
27	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.64512926
28	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.60088787
29	CBP_20019798_ChIP-Seq_JUKART_Human	1.60088787
30	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.59407088
31	SMAD4_21799915_ChIP-Seq_A2780_Human	1.59377231
32	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.59137942
33	MYC_18940864_ChIP-ChIP_HL60_Human	1.55299771
34	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.52130781
35	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.51796702
36	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.51395040
37	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.50991009
38	IRF1_19129219_ChIP-ChIP_H3396_Human	1.49678567
39	REST_21632747_ChIP-Seq_MESCs_Mouse	1.49571244
40	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.47050558
41	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.43643876
42	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.39246469
43	STAT3_23295773_ChIP-Seq_U87_Human	1.38967913
44	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.38201816
45	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.37912963
46	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.37912963
47	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.37316490
48	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.33851811
49	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.32689616
50	ELK1_19687146_ChIP-ChIP_HELA_Human	1.28463209
51	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.25938481
52	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.25881979
53	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.25652683
54	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.24265892
55	TCF4_23295773_ChIP-Seq_U87_Human	1.24242364
56	TP53_22573176_ChIP-Seq_HFKS_Human	1.23278034
57	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.21569064
58	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.19359730
59	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.19311776
60	AR_25329375_ChIP-Seq_VCAP_Human	1.18994874
61	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.16017037
62	JUN_21703547_ChIP-Seq_K562_Human	1.15483139
63	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.13739472
64	ER_23166858_ChIP-Seq_MCF-7_Human	1.13568364
65	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.11511053
66	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.10994680
67	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.10648271
68	RUNX2_22187159_ChIP-Seq_PCA_Human	1.09888737
69	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.09813615
70	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.09196183
71	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.08426226
72	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.07325601
73	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.06222428
74	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.05839697
75	VDR_23849224_ChIP-Seq_CD4+_Human	1.04936965
76	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.04552045
77	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.03239134
78	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.02871622
79	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.01652931
80	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.01642665
81	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.01057583
82	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.00541078
83	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.99013382
84	ETS1_20019798_ChIP-Seq_JURKAT_Human	0.98324437
85	WDR5_24793694_ChIP-Seq_LNCAP_Human	0.97650664
86	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	0.97273065
87	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	0.96987615
88	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.96763928
89	JARID2_20064375_ChIP-Seq_MESCs_Mouse	0.95418653
90	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.94809140
91	NANOG_19829295_ChIP-Seq_ESCs_Human	0.94502308
92	SOX2_19829295_ChIP-Seq_ESCs_Human	0.94502308
93	GABP_19822575_ChIP-Seq_HepG2_Human	0.94172138
94	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.93969628
95	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.93438369
96	HTT_18923047_ChIP-ChIP_STHdh_Human	0.92835767
97	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	0.92035847
98	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.91698574
99	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.88807600
100	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.88294446

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003880_abnormal_central_pattern	5.04403058
2	MP0001529_abnormal_vocalization	3.84842133
3	MP0004859_abnormal_synaptic_plasticity	3.51265904
4	MP0002102_abnormal_ear_morphology	3.36829198
5	MP0003122_maternal_imprinting	3.17051924
6	MP0006276_abnormal_autonomic_nervous	2.87158046
7	MP0001984_abnormal_olfaction	2.82162595
8	MP0002822_catalepsy	2.45344028
9	MP0005499_abnormal_olfactory_system	2.28969207
10	MP0005394_taste/olfaction_phenotype	2.28969207
11	MP0006072_abnormal_retinal_apoptosis	2.22053061
12	MP0000778_abnormal_nervous_system	2.19567849
13	MP0004270_analgesia	2.14658990
14	MP0003221_abnormal_cardiomyocyte_apopto	2.06859175
15	MP0005423_abnormal_somatic_nervous	2.06469700
16	MP0008789_abnormal_olfactory_epithelium	2.00586954
17	MP0001486_abnormal_startle_reflex	1.97796676
18	MP0000049_abnormal_middle_ear	1.95444382
19	MP0003635_abnormal_synaptic_transmissio	1.94780444
20	MP0004133_heterotaxia	1.91069266
21	MP0009745_abnormal_behavioral_response	1.86976092
22	MP0005253_abnormal_eye_physiology	1.76884773
23	MP0009046_muscle_twitch	1.74242311
24	MP0003567_abnormal_fetal_cardiomyocyte	1.73048866
25	MP0008995_early_reproductive_senescence	1.71399586
26	MP0003121_genomic_imprinting	1.71374876
27	MP0004142_abnormal_muscle_tone	1.68693553
28	MP0009697_abnormal_copulation	1.66799350
29	MP0004811_abnormal_neuron_physiology	1.63682986
30	MP0004742_abnormal_vestibular_system	1.62120755
31	MP0000383_abnormal_hair_follicle	1.61759107
32	MP0002063_abnormal_learning/memory/cond	1.60680937
33	MP0008877_abnormal_DNA_methylation	1.59458816
34	MP0000751_myopathy	1.56443644
35	MP0002272_abnormal_nervous_system	1.50650741
36	MP0002736_abnormal_nociception_after	1.50521452
37	MP0005551_abnormal_eye_electrophysiolog	1.50382539
38	MP0002184_abnormal_innervation	1.48213609
39	MP0002572_abnormal_emotion/affect_behav	1.47910392
40	MP0002734_abnormal_mechanical_nocicepti	1.46357061
41	MP0003787_abnormal_imprinting	1.40085496
42	MP0002735_abnormal_chemical_nociception	1.38472966
43	MP0001968_abnormal_touch/_nociception	1.37012527
44	MP0004885_abnormal_endolymph	1.31554946
45	MP0005645_abnormal_hypothalamus_physiol	1.31175118
46	MP0004924_abnormal_behavior	1.30096580
47	MP0005386_behavior/neurological_phenoty	1.30096580
48	MP0006292_abnormal_olfactory_placode	1.27367844
49	MP0001485_abnormal_pinna_reflex	1.27330211
50	MP0002067_abnormal_sensory_capabilities	1.24395397
51	MP0001764_abnormal_homeostasis	1.23635622
52	MP0000647_abnormal_sebaceous_gland	1.17261149
53	MP0003890_abnormal_embryonic-extraembry	1.14596203
54	MP0003137_abnormal_impulse_conducting	1.13950206
55	MP0002557_abnormal_social/conspecific_i	1.12717047
56	MP0002332_abnormal_exercise_endurance	1.11218234
57	MP0001905_abnormal_dopamine_level	1.10565868
58	MP0001970_abnormal_pain_threshold	1.08024771
59	MP0001502_abnormal_circadian_rhythm	1.07973281
60	MP0000955_abnormal_spinal_cord	1.07902544
61	MP0002882_abnormal_neuron_morphology	1.05180185
62	MP0002752_abnormal_somatic_nervous	1.04919024
63	MP0001963_abnormal_hearing_physiology	1.03888384
64	MP0002064_seizures	1.02088097
65	MP0000631_abnormal_neuroendocrine_gland	1.00602040
66	MP0004145_abnormal_muscle_electrophysio	0.98663629
67	MP0005084_abnormal_gallbladder_morpholo	0.98542020
68	MP0004484_altered_response_of	0.98461208
69	MP0002638_abnormal_pupillary_reflex	0.96744614
70	MP0010678_abnormal_skin_adnexa	0.96374060
71	MP0005391_vision/eye_phenotype	0.93915647
72	MP0000026_abnormal_inner_ear	0.93064174
73	MP0005187_abnormal_penis_morphology	0.92336073
74	MP0004134_abnormal_chest_morphology	0.90279349
75	MP0002090_abnormal_vision	0.89405081
76	MP0003786_premature_aging	0.89317077
77	MP0003698_abnormal_male_reproductive	0.87708512
78	MP0005248_abnormal_Harderian_gland	0.87026145
79	MP0002177_abnormal_outer_ear	0.86649484
80	MP0002751_abnormal_autonomic_nervous	0.86411537
81	MP0002152_abnormal_brain_morphology	0.85977134
82	MP0002066_abnormal_motor_capabilities/c	0.85272911
83	MP0002233_abnormal_nose_morphology	0.84098196
84	MP0002069_abnormal_eating/drinking_beha	0.83322569
85	MP0004043_abnormal_pH_regulation	0.82963277
86	MP0006035_abnormal_mitochondrial_morpho	0.82423112
87	MP0004147_increased_porphyrin_level	0.80516097
88	MP0001270_distended_abdomen	0.80270366
89	MP0005377_hearing/vestibular/ear_phenot	0.78982493
90	MP0003878_abnormal_ear_physiology	0.78982493
91	MP0003861_abnormal_nervous_system	0.78576351
92	MP0003119_abnormal_digestive_system	0.77374108
93	MP0004215_abnormal_myocardial_fiber	0.74939702
94	MP0001501_abnormal_sleep_pattern	0.74008185
95	MP0003938_abnormal_ear_development	0.73556113
96	MP0001986_abnormal_taste_sensitivity	0.72823770
97	MP0001299_abnormal_eye_distance/	0.71400846
98	MP0002249_abnormal_larynx_morphology	0.70192497
99	MP0008932_abnormal_embryonic_tissue	0.69242626
100	MP0001286_abnormal_eye_development	0.68669988

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Cortical dysplasia (HP:0002539)	4.67905879
2	Failure to thrive in infancy (HP:0001531)	4.54419305
3	Polyphagia (HP:0002591)	4.47202233
4	Degeneration of the lateral corticospinal tracts (HP:0002314)	3.73733989
5	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	3.73733989
6	Urinary urgency (HP:0000012)	3.72683566
7	Shoulder girdle muscle weakness (HP:0003547)	3.69475859
8	Abnormality of the musculature of the pelvis (HP:0001469)	3.56077863
9	Abnormality of the hip-girdle musculature (HP:0001445)	3.56077863
10	Amyotrophic lateral sclerosis (HP:0007354)	3.53264979
11	Abnormality of the labia minora (HP:0012880)	3.48041974
12	Progressive inability to walk (HP:0002505)	3.35092408
13	True hermaphroditism (HP:0010459)	3.34372740
14	Atonic seizures (HP:0010819)	3.30837189
15	Impaired vibration sensation in the lower limbs (HP:0002166)	3.29275789
16	Abnormality of the corticospinal tract (HP:0002492)	3.21610315
17	Colon cancer (HP:0003003)	3.19434349
18	Pelvic girdle muscle weakness (HP:0003749)	3.03411708
19	Termporal pattern (HP:0011008)	2.84970132
20	Insidious onset (HP:0003587)	2.84970132
21	Drooling (HP:0002307)	2.82793928
22	Pancreatic cysts (HP:0001737)	2.82360162
23	Abnormality of the lower motor neuron (HP:0002366)	2.82182081
24	Neonatal respiratory distress (HP:0002643)	2.79756679
25	Febrile seizures (HP:0002373)	2.76365117
26	Lissencephaly (HP:0001339)	2.70204272
27	Spastic gait (HP:0002064)	2.69511224
28	Abnormality of midbrain morphology (HP:0002418)	2.69104253
29	Molar tooth sign on MRI (HP:0002419)	2.69104253
30	Severe Myopia (HP:0011003)	2.63641032
31	Retinal dysplasia (HP:0007973)	2.63240616
32	Gait imbalance (HP:0002141)	2.61833213
33	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.60189208
34	Excessive salivation (HP:0003781)	2.58599338
35	Short tibia (HP:0005736)	2.58578013
36	Medial flaring of the eyebrow (HP:0010747)	2.58545353
37	Limb dystonia (HP:0002451)	2.54903072
38	Congenital primary aphakia (HP:0007707)	2.52994454
39	Pancreatic fibrosis (HP:0100732)	2.49002670
40	Nephrogenic diabetes insipidus (HP:0009806)	2.46155428
41	Ankle clonus (HP:0011448)	2.43936670
42	Abnormal eating behavior (HP:0100738)	2.43063035
43	Hyperventilation (HP:0002883)	2.39662371
44	Urinary bladder sphincter dysfunction (HP:0002839)	2.37759773
45	Broad-based gait (HP:0002136)	2.37354027
46	Atrophy/Degeneration involving motor neurons (HP:0007373)	2.36402970
47	Pachygyria (HP:0001302)	2.33429124
48	Hypothermia (HP:0002045)	2.26527216
49	Amblyopia (HP:0000646)	2.26425062
50	Occipital encephalocele (HP:0002085)	2.26086919
51	Supernumerary spleens (HP:0009799)	2.26018222
52	Inability to walk (HP:0002540)	2.22382966
53	Genital tract atresia (HP:0001827)	2.20046191
54	Hypoplasia of the brainstem (HP:0002365)	2.18501713
55	Aplasia/Hypoplasia of the brainstem (HP:0007362)	2.18501713
56	Decreased number of large peripheral myelinated nerve fibers (HP:0003387)	2.17757667
57	Esotropia (HP:0000565)	2.14941609
58	Lower limb muscle weakness (HP:0007340)	2.13724501
59	Myokymia (HP:0002411)	2.11889649
60	Vaginal atresia (HP:0000148)	2.10949365
61	Nephronophthisis (HP:0000090)	2.09405022
62	Patellar aplasia (HP:0006443)	2.06923895
63	Morphological abnormality of the pyramidal tract (HP:0002062)	2.05639961
64	Specific learning disability (HP:0001328)	2.04426922
65	Abnormality of the metopic suture (HP:0005556)	2.04423728
66	Absence seizures (HP:0002121)	2.03986654
67	Bicornuate uterus (HP:0000813)	2.02029686
68	Genetic anticipation (HP:0003743)	2.01472801
69	Dialeptic seizures (HP:0011146)	2.01006515
70	Abnormal biliary tract physiology (HP:0012439)	2.00245319
71	Bile duct proliferation (HP:0001408)	2.00245319
72	Focal seizures (HP:0007359)	2.00111424
73	Hepatoblastoma (HP:0002884)	1.98418874
74	Progressive cerebellar ataxia (HP:0002073)	1.98188219
75	Decreased muscle mass (HP:0003199)	1.97958435
76	Peripheral hypomyelination (HP:0007182)	1.95373337
77	Limb-girdle muscle weakness (HP:0003325)	1.93533936
78	Aplasia/hypoplasia of the uterus (HP:0008684)	1.92561658
79	Hyperglycinemia (HP:0002154)	1.92289753
80	Absent speech (HP:0001344)	1.91350926
81	Aplasia/Hypoplasia of the patella (HP:0006498)	1.90803410
82	Medulloblastoma (HP:0002885)	1.90787276
83	Ulnar claw (HP:0001178)	1.90418029
84	Hypsarrhythmia (HP:0002521)	1.90204338
85	Narrow forehead (HP:0000341)	1.89621780
86	Severe muscular hypotonia (HP:0006829)	1.89525558
87	Agitation (HP:0000713)	1.89432621
88	Poor suck (HP:0002033)	1.89314558
89	Hypoplastic pelvis (HP:0008839)	1.88360002
90	Thyroid-stimulating hormone excess (HP:0002925)	1.88250842
91	Abolished electroretinogram (ERG) (HP:0000550)	1.87639752
92	Epileptic encephalopathy (HP:0200134)	1.86712637
93	Exercise-induced muscle cramps (HP:0003710)	1.86023037
94	Chronic hepatic failure (HP:0100626)	1.85882782
95	Astrocytoma (HP:0009592)	1.85875036
96	Abnormality of the astrocytes (HP:0100707)	1.85875036
97	Cerebellar dysplasia (HP:0007033)	1.85573045
98	Abnormal respiratory epithelium morphology (HP:0012253)	1.83157009
99	Abnormal respiratory motile cilium morphology (HP:0005938)	1.83157009
100	Polymicrogyria (HP:0002126)	1.82386643

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP3K4	5.59092382
2	MAP2K7	5.46458638
3	MAP3K6	3.39705933
4	BCR	3.36272024
5	SRPK1	2.91596012
6	WNK3	2.73004149
7	ERBB3	2.71415849
8	MARK1	2.63885630
9	MAP2K4	2.59904281
10	TRIM28	2.56524831
11	CDK19	2.15651543
12	CASK	2.10931595
13	MAPK13	1.95598093
14	CAMKK2	1.84821951
15	PINK1	1.83333478
16	PLK2	1.82025813
17	CSNK1G2	1.74265009
18	UHMK1	1.67082437
19	CSNK1G3	1.66630553
20	BCKDK	1.61265990
21	CSNK1A1L	1.57550628
22	EPHA4	1.57392704
23	MAP3K5	1.52300213
24	DYRK2	1.49857577
25	DYRK1B	1.39490324
26	PAK3	1.32350456
27	CSNK1G1	1.32094734
28	BRD4	1.30324773
29	DYRK3	1.26288492
30	NEK1	1.22396000
31	SIK3	1.20996575
32	DYRK1A	1.19297977
33	FER	1.09869962
34	MINK1	1.09599922
35	TESK1	1.08454324
36	PLK4	1.06630900
37	LIMK1	1.05849664
38	VRK1	1.03667726
39	RPS6KA4	0.91920721
40	DAPK2	0.90511305
41	CCNB1	0.82397075
42	EPHB1	0.81980861
43	EPHA3	0.80338494
44	PKN1	0.80237461
45	GRK7	0.77751231
46	CDK18	0.76744931
47	CDK14	0.75274443
48	MKNK1	0.71057007
49	PRKCE	0.67334054
50	CDK15	0.66689891
51	INSRR	0.66500281
52	CDK11A	0.65915045
53	CDK5	0.65570116
54	ADRBK2	0.64831675
55	CAMK2A	0.63266948
56	PAK6	0.62199263
57	CAMKK1	0.61357681
58	PRKCG	0.59233210
59	CAMK1	0.58871122
60	TESK2	0.58393474
61	PLK3	0.57823125
62	PLK1	0.57403061
63	CAMK4	0.55943685
64	STK38	0.55479407
65	RET	0.51364669
66	TIE1	0.49200966
67	OXSR1	0.48443141
68	GRK1	0.48019454
69	PIK3CG	0.44720202
70	PTK2B	0.44165156
71	NME1	0.43314627
72	VRK2	0.41011225
73	MARK2	0.40577392
74	CAMK2B	0.40250811
75	STK38L	0.39146546
76	CSNK1D	0.38042131
77	ERBB2	0.36730771
78	BMPR1B	0.36648233
79	PRKACA	0.35591873
80	MAP4K2	0.34189246
81	MAPK9	0.33382970
82	FRK	0.33209263
83	TAOK1	0.32572547
84	IRAK1	0.31745616
85	PRKG1	0.30992280
86	CSNK1A1	0.30963956
87	GRK5	0.30952911
88	NUAK1	0.30057033
89	MATK	0.29831241
90	RPS6KA5	0.29761888
91	PRKAA1	0.28158645
92	AURKB	0.27424495
93	FLT3	0.26903435
94	NTRK2	0.26523877
95	PRKACB	0.26261475
96	PIM2	0.25518169
97	PRKCB	0.24322509
98	AURKA	0.23948597
99	TNK2	0.22047800
100	PRKACG	0.21488525

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotine addiction_Homo sapiens_hsa05033	5.08190342
2	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	3.22824463
3	GABAergic synapse_Homo sapiens_hsa04727	3.08248777
4	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.89328279
5	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.80196629
6	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	2.59558524
7	Protein export_Homo sapiens_hsa03060	2.46798216
8	Morphine addiction_Homo sapiens_hsa05032	2.46623591
9	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.19341538
10	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	2.11442099
11	Steroid biosynthesis_Homo sapiens_hsa00100	2.02428090
12	Cocaine addiction_Homo sapiens_hsa05030	1.76724376
13	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.75637901
14	Glutamatergic synapse_Homo sapiens_hsa04724	1.74207968
15	Taste transduction_Homo sapiens_hsa04742	1.71573299
16	Phototransduction_Homo sapiens_hsa04744	1.70828050
17	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.68444718
18	Dopaminergic synapse_Homo sapiens_hsa04728	1.66447950
19	Serotonergic synapse_Homo sapiens_hsa04726	1.54192887
20	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.53114381
21	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	1.47138922
22	Circadian entrainment_Homo sapiens_hsa04713	1.44804555
23	Propanoate metabolism_Homo sapiens_hsa00640	1.43825287
24	Parkinsons disease_Homo sapiens_hsa05012	1.43765861
25	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.41321137
26	Ether lipid metabolism_Homo sapiens_hsa00565	1.41123480
27	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.37602396
28	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.33129801
29	Linoleic acid metabolism_Homo sapiens_hsa00591	1.29577073
30	Fanconi anemia pathway_Homo sapiens_hsa03460	1.25708372
31	Butanoate metabolism_Homo sapiens_hsa00650	1.20831383
32	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.19140072
33	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.18445152
34	Oxidative phosphorylation_Homo sapiens_hsa00190	1.15767062
35	Alcoholism_Homo sapiens_hsa05034	1.12163417
36	Huntingtons disease_Homo sapiens_hsa05016	1.10534538
37	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.10153803
38	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.08505060
39	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.05755046
40	Spliceosome_Homo sapiens_hsa03040	1.04518425
41	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.03769227
42	Mismatch repair_Homo sapiens_hsa03430	1.02031174
43	Oocyte meiosis_Homo sapiens_hsa04114	1.01548502
44	Base excision repair_Homo sapiens_hsa03410	1.00197370
45	Basal transcription factors_Homo sapiens_hsa03022	0.99720499
46	Regulation of autophagy_Homo sapiens_hsa04140	0.97436505
47	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.96687399
48	mRNA surveillance pathway_Homo sapiens_hsa03015	0.96448676
49	Axon guidance_Homo sapiens_hsa04360	0.94227336
50	Fatty acid elongation_Homo sapiens_hsa00062	0.93571768
51	Amphetamine addiction_Homo sapiens_hsa05031	0.93351402
52	Type II diabetes mellitus_Homo sapiens_hsa04930	0.92706793
53	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.88739787
54	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.88194864
55	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.85310287
56	Cardiac muscle contraction_Homo sapiens_hsa04260	0.77893990
57	Long-term depression_Homo sapiens_hsa04730	0.73729238
58	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.73183255
59	RNA transport_Homo sapiens_hsa03013	0.70158221
60	Salmonella infection_Homo sapiens_hsa05132	0.67509510
61	Shigellosis_Homo sapiens_hsa05131	0.67153389
62	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.67133984
63	Cholinergic synapse_Homo sapiens_hsa04725	0.65454048
64	Alzheimers disease_Homo sapiens_hsa05010	0.63370445
65	Arginine and proline metabolism_Homo sapiens_hsa00330	0.57053191
66	Olfactory transduction_Homo sapiens_hsa04740	0.54602711
67	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.54080871
68	Gap junction_Homo sapiens_hsa04540	0.51352340
69	RNA degradation_Homo sapiens_hsa03018	0.47682036
70	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.46752733
71	Metabolic pathways_Homo sapiens_hsa01100	0.46561955
72	Carbon metabolism_Homo sapiens_hsa01200	0.43335007
73	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.40638559
74	AMPK signaling pathway_Homo sapiens_hsa04152	0.40069204
75	Fatty acid metabolism_Homo sapiens_hsa01212	0.39793298
76	Peroxisome_Homo sapiens_hsa04146	0.39490142
77	Insulin secretion_Homo sapiens_hsa04911	0.38614156
78	Ras signaling pathway_Homo sapiens_hsa04014	0.37917186
79	Calcium signaling pathway_Homo sapiens_hsa04020	0.37815747
80	Pyrimidine metabolism_Homo sapiens_hsa00240	0.37260207
81	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.36702710
82	Wnt signaling pathway_Homo sapiens_hsa04310	0.36639738
83	Purine metabolism_Homo sapiens_hsa00230	0.34467055
84	cAMP signaling pathway_Homo sapiens_hsa04024	0.32804127
85	Colorectal cancer_Homo sapiens_hsa05210	0.32516826
86	Salivary secretion_Homo sapiens_hsa04970	0.29881436
87	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.29399145
88	Cell cycle_Homo sapiens_hsa04110	0.28876007
89	Collecting duct acid secretion_Homo sapiens_hsa04966	0.28618906
90	Circadian rhythm_Homo sapiens_hsa04710	0.28178937
91	Phagosome_Homo sapiens_hsa04145	0.27260536
92	beta-Alanine metabolism_Homo sapiens_hsa00410	0.26691205
93	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.25026795
94	RNA polymerase_Homo sapiens_hsa03020	0.24749649
95	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.24300250
96	Nitrogen metabolism_Homo sapiens_hsa00910	0.23816651
97	Hippo signaling pathway_Homo sapiens_hsa04390	0.23002187
98	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.22896713
99	Phenylalanine metabolism_Homo sapiens_hsa00360	0.22896225
100	Tryptophan metabolism_Homo sapiens_hsa00380	0.21875533

TRBV26OR9-2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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