TRBV28

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nucleotide salvage (GO:0043173)6.11108048
2neutrophil activation involved in immune response (GO:0002283)5.67489883
3activated T cell proliferation (GO:0050798)5.63746487
4nucleoside salvage (GO:0043174)5.58534048
5positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.43374655
6negative regulation of thymocyte apoptotic process (GO:0070244)5.42368869
7pyrimidine-containing compound salvage (GO:0008655)5.38888708
8pyrimidine nucleoside salvage (GO:0043097)5.38888708
9regulation of regulatory T cell differentiation (GO:0045589)5.10496291
10negative regulation of T-helper cell differentiation (GO:0045623)5.01187033
11negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)5.01187033
12negative T cell selection (GO:0043383)4.99916357
13positive regulation of immune response to tumor cell (GO:0002839)4.90220924
14regulation of immune response to tumor cell (GO:0002837)4.90220924
15regulation of response to tumor cell (GO:0002834)4.90220924
16positive regulation of response to tumor cell (GO:0002836)4.90220924
17negative thymic T cell selection (GO:0045060)4.81494931
18purine nucleotide salvage (GO:0032261)4.80017501
19positive regulation of gamma-delta T cell activation (GO:0046645)4.75221320
20pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)4.73076994
21UMP metabolic process (GO:0046049)4.73076994
22pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)4.73076994
23UMP biosynthetic process (GO:0006222)4.73076994
24positive regulation of alpha-beta T cell proliferation (GO:0046641)4.61710804
25negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)4.54369493
26positive regulation of granulocyte differentiation (GO:0030854)4.37226065
27regulation of memory T cell differentiation (GO:0043380)4.36781322
28thrombin receptor signaling pathway (GO:0070493)4.19220894
29regulation of T-helper 1 cell differentiation (GO:0045625)4.15287470
30regulation of alpha-beta T cell proliferation (GO:0046640)4.12792165
31positive regulation of natural killer cell mediated immunity (GO:0002717)4.04881048
32pyrimidine nucleoside monophosphate metabolic process (GO:0009129)3.95483480
33positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.87849384
34T cell selection (GO:0045058)3.84707327
35regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.81397144
36regulation of natural killer cell mediated immunity (GO:0002715)3.81397144
37regulation of B cell receptor signaling pathway (GO:0050855)3.79149074
38pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)3.70752705
39antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.69658101
40regulation of B cell differentiation (GO:0045577)3.66091619
41positive regulation of T cell cytokine production (GO:0002726)3.64465549
42antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.57889387
43regulation of gamma-delta T cell differentiation (GO:0045586)3.54256272
44leukocyte degranulation (GO:0043299)3.52883754
45thymic T cell selection (GO:0045061)3.49467209
46positive regulation of isotype switching (GO:0045830)3.48199358
47neutrophil activation (GO:0042119)3.48125071
48negative regulation of alpha-beta T cell differentiation (GO:0046639)3.45061784
49regulation of T cell receptor signaling pathway (GO:0050856)3.44259061
50positive regulation of DNA recombination (GO:0045911)3.41663191
51regulation of gamma-delta T cell activation (GO:0046643)3.41294962
52regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.39435042
53leukocyte aggregation (GO:0070486)3.39107504
54positive regulation of mast cell activation (GO:0033005)3.35862626
55T cell proliferation (GO:0042098)3.34069782
56regulation of thymocyte apoptotic process (GO:0070243)3.33330411
57positive regulation of macrophage differentiation (GO:0045651)3.32028031
58positive regulation of immunoglobulin mediated immune response (GO:0002891)3.27614056
59positive regulation of B cell mediated immunity (GO:0002714)3.27614056
60negative regulation of T cell apoptotic process (GO:0070233)3.26705002
61Peyers patch development (GO:0048541)3.24880022
62mucosal-associated lymphoid tissue development (GO:0048537)3.24880022
63hepatocyte apoptotic process (GO:0097284)3.23879237
64tolerance induction (GO:0002507)3.23488285
65antigen processing and presentation of endogenous antigen (GO:0019883)3.22448871
66positive T cell selection (GO:0043368)3.21919422
67regulation of platelet aggregation (GO:0090330)3.21177446
68positive regulation of B cell differentiation (GO:0045579)3.21172775
69antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.20497171
70regulation of activation of Janus kinase activity (GO:0010533)3.15161469
71autophagic vacuole fusion (GO:0000046)3.12992051
72positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.11698121
73positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.11004856
74positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.08156594
75megakaryocyte development (GO:0035855)3.06044487
76mast cell activation (GO:0045576)3.05912370
77response to interleukin-15 (GO:0070672)3.05606119
78positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.05099733
79angiogenesis involved in wound healing (GO:0060055)3.01813031
80granulocyte activation (GO:0036230)3.01116433
81regulation of B cell mediated immunity (GO:0002712)3.00889366
82dendritic cell chemotaxis (GO:0002407)2.99594421
83positive regulation of interleukin-4 production (GO:0032753)2.99284508
84positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.98007270
85negative regulation of interleukin-17 production (GO:0032700)2.96840550
86G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.94447317
87purine-containing compound salvage (GO:0043101)2.91354353
88positive thymic T cell selection (GO:0045059)2.90967786
89regulation of leukocyte mediated cytotoxicity (GO:0001910)2.90684625
90negative regulation of alpha-beta T cell activation (GO:0046636)2.89986871
91organelle membrane fusion (GO:0090174)2.88499842
92regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.87926124
93regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.87088032
94cellular extravasation (GO:0045123)2.85837716
95protein neddylation (GO:0045116)2.82485644
96regulation of RIG-I signaling pathway (GO:0039535)2.82334091
97negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.80697177
98T cell migration (GO:0072678)2.80629730
99regulation of immunoglobulin mediated immune response (GO:0002889)2.80497403
100regulation of T cell cytokine production (GO:0002724)2.79820781

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse6.37622007
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.02460300
3RUNX_20019798_ChIP-Seq_JUKART_Human4.08311464
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.82740997
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.47013843
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.46718756
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.45831774
8SCL_19346495_ChIP-Seq_HPC-7_Human3.29764072
9IRF8_21731497_ChIP-ChIP_J774_Mouse3.29296233
10STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.01874549
11MYB_26560356_Chip-Seq_TH2_Human2.76745128
12SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.65526960
13LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.44444992
14RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.42707687
15SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.35289123
16FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.34634070
17PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.20531090
18GATA3_26560356_Chip-Seq_TH2_Human2.18689823
19STAT4_19710469_ChIP-ChIP_TH1__Mouse2.14975623
20ELF1_17652178_ChIP-ChIP_JURKAT_Human2.13606426
21UTX_26944678_Chip-Seq_JUKART_Human2.05833943
22IRF8_27001747_Chip-Seq_BMDM_Mouse2.04407726
23GATA3_27048872_Chip-Seq_THYMUS_Human2.01892856
24FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.00919232
25MYB_26560356_Chip-Seq_TH1_Human1.99812228
26LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.96395163
27SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.85945891
28GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.84937739
29E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.78996864
30SPI1_23547873_ChIP-Seq_NB4_Human1.77649167
31FLI1_27457419_Chip-Seq_LIVER_Mouse1.72201186
32MAF_26560356_Chip-Seq_TH1_Human1.70766963
33RUNX1_22412390_ChIP-Seq_EML_Mouse1.69338039
34MYB_21317192_ChIP-Seq_ERMYB_Mouse1.66334109
35SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.66330305
36NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.62469499
37SPI1_23127762_ChIP-Seq_K562_Human1.60934804
38GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.54406845
39NOTCH1_21737748_ChIP-Seq_TLL_Human1.53514669
40GATA1_19941827_ChIP-Seq_MEL_Mouse1.52937048
41PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.44865650
42VDR_22108803_ChIP-Seq_LS180_Human1.41665272
43PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.41493459
44CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.38433212
45IRF1_19129219_ChIP-ChIP_H3396_Human1.37483145
46GATA1_19941826_ChIP-Seq_K562_Human1.37481295
47BP1_19119308_ChIP-ChIP_Hs578T_Human1.33521684
48FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.33323425
49GATA2_19941826_ChIP-Seq_K562_Human1.31336275
50GATA1_22383799_ChIP-Seq_G1ME_Mouse1.29931145
51MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.26270943
52SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.26243752
53RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.25512463
54GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22298225
55IGF1R_20145208_ChIP-Seq_DFB_Human1.21099973
56TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.20728023
57STAT6_21828071_ChIP-Seq_BEAS2B_Human1.19186417
58EZH2_27294783_Chip-Seq_NPCs_Mouse1.17383590
59GATA3_26560356_Chip-Seq_TH1_Human1.16461245
60GATA2_22383799_ChIP-Seq_G1ME_Mouse1.15341936
61MYC_22102868_ChIP-Seq_BL_Human1.14287598
62SUZ12_27294783_Chip-Seq_NPCs_Mouse1.13793409
63BRD4_27068464_Chip-Seq_AML-cells_Mouse1.13528838
64HTT_18923047_ChIP-ChIP_STHdh_Human1.12483080
65PCGF2_27294783_Chip-Seq_NPCs_Mouse1.11637127
66PU_27001747_Chip-Seq_BMDM_Mouse1.10791595
67VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.10396284
68GATA1_22025678_ChIP-Seq_K562_Human1.09985930
69MAF_26560356_Chip-Seq_TH2_Human1.09345890
70GATA2_21666600_ChIP-Seq_HMVEC_Human1.07148544
71Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.06529737
72PCGF2_27294783_Chip-Seq_ESCs_Mouse1.06022754
73SALL4_22934838_ChIP-ChIP_CD34+_Human1.04918597
74KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.03435053
75NFE2_27457419_Chip-Seq_LIVER_Mouse1.02027021
76TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.00375578
77HOXB4_20404135_ChIP-ChIP_EML_Mouse0.98829933
78RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.97751033
79IKZF1_21737484_ChIP-ChIP_HCT116_Human0.97714304
80CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97005116
81ER_23166858_ChIP-Seq_MCF-7_Human0.96067636
82FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95578212
83VDR_24763502_ChIP-Seq_THP-1_Human0.95155692
84BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.93468573
85CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.91261899
86SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.91224398
87VDR_24787735_ChIP-Seq_THP-1_Human0.88549028
88TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.87699334
89HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.86445190
90TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.86067903
91GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.85830509
92CRX_20693478_ChIP-Seq_RETINA_Mouse0.85001468
93GATA3_21878914_ChIP-Seq_MCF-7_Human0.84725385
94GATA1_19941827_ChIP-Seq_MEL86_Mouse0.84561052
95SPI1_20517297_ChIP-Seq_HL60_Human0.83974266
96OCT4_21477851_ChIP-Seq_ESCs_Mouse0.82338644
97VDR_23849224_ChIP-Seq_CD4+_Human0.82004771
98EGR1_23403033_ChIP-Seq_LIVER_Mouse0.81650986
99SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.80546913
100EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.79196214

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005464_abnormal_platelet_physiology4.85195057
2MP0003724_increased_susceptibility_to4.21456836
3MP0001835_abnormal_antigen_presentation3.83557340
4MP0005671_abnormal_response_to3.42028522
5MP0002163_abnormal_gland_morphology3.31205632
6MP0003763_abnormal_thymus_physiology3.22621220
7MP0005000_abnormal_immune_tolerance2.88976105
8MP0001790_abnormal_immune_system2.83587138
9MP0005387_immune_system_phenotype2.83587138
10MP0002148_abnormal_hypersensitivity_rea2.75079832
11MP0003436_decreased_susceptibility_to2.46203861
12MP0000685_abnormal_immune_system2.38231722
13MP0001800_abnormal_humoral_immune2.37484761
14MP0010155_abnormal_intestine_physiology2.27387948
15MP0008004_abnormal_stomach_pH2.25327035
16MP0002723_abnormal_immune_serum2.22765180
17MP0000465_gastrointestinal_hemorrhage2.13592833
18MP0002398_abnormal_bone_marrow2.10900481
19MP0002420_abnormal_adaptive_immunity2.10102005
20MP0001819_abnormal_immune_cell2.06060295
21MP0008872_abnormal_physiological_respon2.05196823
22MP0009333_abnormal_splenocyte_physiolog2.04679577
23MP0003183_abnormal_peptide_metabolism2.04262791
24MP0005167_abnormal_blood-brain_barrier2.03683632
25MP0002452_abnormal_antigen_presenting2.02781241
26MP0000703_abnormal_thymus_morphology1.92190260
27MP0001873_stomach_inflammation1.88972605
28MP0005025_abnormal_response_to1.87622481
29MP0009785_altered_susceptibility_to1.87250907
30MP0002166_altered_tumor_susceptibility1.85870915
31MP0003300_gastrointestinal_ulcer1.83494618
32MP0005379_endocrine/exocrine_gland_phen1.82951944
33MP0005670_abnormal_white_adipose1.80074727
34MP0000716_abnormal_immune_system1.77318624
35MP0008961_abnormal_basal_metabolism1.76887814
36MP0000689_abnormal_spleen_morphology1.76879328
37MP0002722_abnormal_immune_system1.72463113
38MP0006082_CNS_inflammation1.71865713
39MP0004947_skin_inflammation1.70306284
40MP0002419_abnormal_innate_immunity1.69692642
41MP0003866_abnormal_defecation1.67022617
42MP0004381_abnormal_hair_follicle1.62805727
43MP0002429_abnormal_blood_cell1.53860304
44MP0005645_abnormal_hypothalamus_physiol1.50362694
45MP0001845_abnormal_inflammatory_respons1.49057668
46MP0005310_abnormal_salivary_gland1.48392834
47MP0003303_peritoneal_inflammation1.48324426
48MP0004084_abnormal_cardiac_muscle1.47864409
49MP0002132_abnormal_respiratory_system1.43242508
50MP0002405_respiratory_system_inflammati1.41133693
51MP0001663_abnormal_digestive_system1.39468301
52MP0001533_abnormal_skeleton_physiology1.31420363
53MP0004510_myositis1.30755697
54MP0001348_abnormal_lacrimal_gland1.24520553
55MP0002006_tumorigenesis1.22575273
56MP0004036_abnormal_muscle_relaxation1.12328473
57MP0009764_decreased_sensitivity_to1.10354969
58MP0009763_increased_sensitivity_to1.04284099
59MP0005410_abnormal_fertilization1.01586228
60MP0005084_abnormal_gallbladder_morpholo1.00439867
61MP0005075_abnormal_melanosome_morpholog0.93342559
62MP0000249_abnormal_blood_vessel0.89361765
63MP0003806_abnormal_nucleotide_metabolis0.89233253
64MP0003638_abnormal_response/metabolism_0.87658065
65MP0002998_abnormal_bone_remodeling0.87248283
66MP0001765_abnormal_ion_homeostasis0.86358948
67MP0008469_abnormal_protein_level0.86002423
68MP0001851_eye_inflammation0.85024029
69MP0008775_abnormal_heart_ventricle0.81715017
70MP0004215_abnormal_myocardial_fiber0.79092901
71MP0009697_abnormal_copulation0.77323218
72MP0005381_digestive/alimentary_phenotyp0.76738988
73MP0010329_abnormal_lipoprotein_level0.76715858
74MP0008875_abnormal_xenobiotic_pharmacok0.75622068
75MP0003656_abnormal_erythrocyte_physiolo0.74976718
76MP0000383_abnormal_hair_follicle0.74558302
77MP0000230_abnormal_systemic_arterial0.73445978
78MP0000858_altered_metastatic_potential0.72980511
79MP0008873_increased_physiological_sensi0.72810098
80MP0009765_abnormal_xenobiotic_induced0.69766820
81MP0004808_abnormal_hematopoietic_stem0.69723810
82MP0001968_abnormal_touch/_nociception0.67068227
83MP0000569_abnormal_digit_pigmentation0.66875359
84MP0002396_abnormal_hematopoietic_system0.65904523
85MP0001666_abnormal_nutrient_absorption0.65354552
86MP0002693_abnormal_pancreas_physiology0.65001020
87MP0000490_abnormal_crypts_of0.64879877
88MP0000343_altered_response_to0.62497010
89MP0009642_abnormal_blood_homeostasis0.60645688
90MP0001905_abnormal_dopamine_level0.60376955
91MP0002019_abnormal_tumor_incidence0.60313194
92MP0002138_abnormal_hepatobiliary_system0.59639538
93MP0001346_abnormal_lacrimal_gland0.59195248
94MP0002933_joint_inflammation0.58888054
95MP0002733_abnormal_thermal_nociception0.58466940
96MP0004883_abnormal_blood_vessel0.57354770
97MP0001853_heart_inflammation0.54315597
98MP0005448_abnormal_energy_balance0.53122803
99MP0003950_abnormal_plasma_membrane0.52590066
100MP0003646_muscle_fatigue0.51048382

Predicted human phenotypes

RankGene SetZ-score
1Prolonged bleeding time (HP:0003010)6.95686913
2Menorrhagia (HP:0000132)5.54145040
3Petechiae (HP:0000967)5.41973157
4Increased mean platelet volume (HP:0011877)5.25288626
5Autoimmune hemolytic anemia (HP:0001890)5.14533506
6Epistaxis (HP:0000421)5.13259679
7Abnormal platelet volume (HP:0011876)5.12902809
8Stomatitis (HP:0010280)5.02425233
9Purpura (HP:0000979)4.82672243
10Gingival bleeding (HP:0000225)4.65559579
11Panhypogammaglobulinemia (HP:0003139)4.37447696
12Autoimmune thrombocytopenia (HP:0001973)4.33667430
13Abnormal delayed hypersensitivity skin test (HP:0002963)4.33557308
14Elevated erythrocyte sedimentation rate (HP:0003565)3.90808642
15Papilledema (HP:0001085)3.52882907
16Increased IgM level (HP:0003496)3.51631224
17Congenital, generalized hypertrichosis (HP:0004540)3.48908005
18Eosinophilia (HP:0001880)3.41401323
19Mediastinal lymphadenopathy (HP:0100721)3.39276218
20Impaired platelet aggregation (HP:0003540)3.28634464
21Abnormal platelet function (HP:0011869)3.28634464
22Abnormality of B cell number (HP:0010975)3.26164718
23Encephalitis (HP:0002383)3.25266740
24Hip dysplasia (HP:0001385)3.17058169
25Abnormality of T cell number (HP:0011839)3.12453638
26Granulocytopenia (HP:0001913)3.12117504
27IgG deficiency (HP:0004315)3.08420554
28B lymphocytopenia (HP:0010976)3.06446064
29Arterial thrombosis (HP:0004420)3.02426618
30Difficulty running (HP:0009046)3.00460620
31Myositis (HP:0100614)2.88434047
32Abnormality of eosinophils (HP:0001879)2.87583909
33Pulmonary infiltrates (HP:0002113)2.86086267
34Abnormality of T cells (HP:0002843)2.85684594
35Agammaglobulinemia (HP:0004432)2.85338001
36Recurrent viral infections (HP:0004429)2.79794868
37Abnormality of the pons (HP:0007361)2.79264657
38Abnormality of T cell physiology (HP:0011840)2.76987638
39Hyperlipoproteinemia (HP:0010980)2.76918024
40Meningitis (HP:0001287)2.74891308
41Abnormality of the prostate (HP:0008775)2.72823605
42T lymphocytopenia (HP:0005403)2.70070084
43Chest pain (HP:0100749)2.69871270
44Recurrent fungal infections (HP:0002841)2.66976935
45Optic neuritis (HP:0100653)2.66558054
46Retrobulbar optic neuritis (HP:0100654)2.66558054
47Gastrointestinal infarctions (HP:0005244)2.66249623
48Spontaneous hematomas (HP:0007420)2.65928490
49Joint swelling (HP:0001386)2.61468516
50Leukocytosis (HP:0001974)2.60599874
51Recurrent cutaneous fungal infections (HP:0011370)2.49762208
52Chronic mucocutaneous candidiasis (HP:0002728)2.49762208
53Thrombocytosis (HP:0001894)2.49075031
54Episodic fever (HP:0001954)2.44493319
55Chronic otitis media (HP:0000389)2.43898609
56Abnormal pupillary function (HP:0007686)2.37116750
57Severe combined immunodeficiency (HP:0004430)2.35923985
58Hypoproteinemia (HP:0003075)2.34144079
59Orchitis (HP:0100796)2.30690962
60Abnormality of the common coagulation pathway (HP:0010990)2.29925645
61Poikilocytosis (HP:0004447)2.27763657
62Thyroiditis (HP:0100646)2.26125773
63Recurrent bacterial skin infections (HP:0005406)2.22227991
64Exertional dyspnea (HP:0002875)2.20650968
65Vasculitis (HP:0002633)2.19723849
66Bruising susceptibility (HP:0000978)2.18506970
67Hypoplasia of the pons (HP:0012110)2.17566049
68Dry hair (HP:0011359)2.15746310
69Pustule (HP:0200039)2.15122571
70Amaurosis fugax (HP:0100576)2.13094155
71Asplenia (HP:0001746)2.13067660
72Hypokalemic alkalosis (HP:0001949)2.11984282
73Acanthocytosis (HP:0001927)2.11014551
74Obstructive lung disease (HP:0006536)2.10829817
75Chronic obstructive pulmonary disease (HP:0006510)2.10829817
76Gangrene (HP:0100758)2.09951340
77Aplasia/Hypoplasia of the spleen (HP:0010451)2.09647508
78Abnormality of macrophages (HP:0004311)2.09286673
79Recurrent skin infections (HP:0001581)2.07686380
80Fatigue (HP:0012378)2.07090986
81Recurrent abscess formation (HP:0002722)2.02642645
82Fair hair (HP:0002286)2.00085905
83Abnormality of cells of the lymphoid lineage (HP:0012140)1.99584615
84Abnormality of the fingertips (HP:0001211)1.97473791
85Keratoconjunctivitis sicca (HP:0001097)1.95374715
86Increased IgE level (HP:0003212)1.94972694
87Hypergammaglobulinemia (HP:0010702)1.92229868
88Keratoconjunctivitis (HP:0001096)1.88278731
89Lymphopenia (HP:0001888)1.88069439
90Dyschromatopsia (HP:0007641)1.87719088
91Congenital stationary night blindness (HP:0007642)1.87461789
92IgA deficiency (HP:0002720)1.84103657
93Mesangial abnormality (HP:0001966)1.83295361
94Pulmonary embolism (HP:0002204)1.83006468
95Chronic diarrhea (HP:0002028)1.82583640
96Abnormality of the renal cortex (HP:0011035)1.81305870
97Spondylolisthesis (HP:0003302)1.80911860
98Abnormality of the anterior horn cell (HP:0006802)1.80705304
99Degeneration of anterior horn cells (HP:0002398)1.80705304
100Abnormality of the Achilles tendon (HP:0005109)1.79941972

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK14.89610514
2MST44.20987193
3RIPK43.97670125
4MAP4K13.57188279
5TEC3.48837012
6TXK3.20576595
7PIK3CG3.05111203
8ITK2.41894664
9BTK2.41585323
10SYK2.30038283
11BMPR22.24559123
12TAOK32.23090229
13CAMKK22.18799586
14FES2.16320175
15CSF1R2.10254795
16MAP2K61.93912458
17NLK1.86039537
18STK241.77895618
19MYLK1.73753445
20FRK1.69140764
21ZAP701.67545455
22MAPKAPK31.64266810
23GRK61.52108028
24ADRBK21.49931572
25LCK1.44697839
26EIF2AK31.44475998
27JAK31.43910173
28HCK1.43470879
29IKBKB1.36006410
30LYN1.28829946
31TNK21.13468725
32MAP3K141.07260083
33STK31.06731959
34BMX1.04880674
35TSSK61.03904925
36MAP3K131.02764463
37KIT1.01626518
38ZAK0.98344011
39IKBKE0.98008494
40PDK10.96868843
41STK160.96865184
42GRK50.95773640
43IRAK10.92168169
44STK390.91807555
45PTK2B0.88495264
46WNK40.87036077
47CAMKK10.85058350
48CSK0.80575865
49TLK10.80203037
50PRKCQ0.78913327
51MAPK110.75304254
52FLT30.73284223
53TAOK20.71754601
54MAP2K30.67073588
55PLK20.65688097
56STK38L0.64655858
57SGK20.62482768
58BLK0.62267997
59BMPR1B0.60242594
60JAK10.58312535
61TAOK10.55849647
62PASK0.55301992
63IRAK40.54671146
64JAK20.53281608
65IGF1R0.51611302
66BCR0.50290386
67ADRBK10.49152093
68HIPK20.48059160
69MAPKAPK20.46795680
70IRAK30.45769037
71PRPF4B0.45237541
72LIMK10.44865421
73CLK10.43515091
74OXSR10.43290978
75MAP3K50.41915241
76MAPK130.38319126
77SIK30.38282835
78FGFR30.38259622
79GRK10.36592360
80NUAK10.34696223
81FYN0.34626267
82MAP3K110.34527387
83PKN10.34270499
84EIF2AK20.31971098
85PRKCB0.31603796
86PRKCD0.31132057
87PRKCH0.31107331
88SGK30.29381295
89MATK0.28695920
90PIM10.28374366
91PRKCA0.27706317
92ACVR1B0.27536466
93PDPK10.27236147
94EPHA30.27198173
95MAP3K30.26750741
96MAP3K120.25742533
97TBK10.25333567
98MAPK120.24489480
99MARK30.23139131
100TNIK0.22902154

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053324.22720190
2Primary immunodeficiency_Homo sapiens_hsa053403.92019760
3Allograft rejection_Homo sapiens_hsa053303.33934719
4Autoimmune thyroid disease_Homo sapiens_hsa053203.16756067
5Platelet activation_Homo sapiens_hsa046113.07569553
6Hematopoietic cell lineage_Homo sapiens_hsa046402.98111572
7Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.68006169
8Antigen processing and presentation_Homo sapiens_hsa046122.55394097
9Intestinal immune network for IgA production_Homo sapiens_hsa046722.48587529
10T cell receptor signaling pathway_Homo sapiens_hsa046602.41173099
11Asthma_Homo sapiens_hsa053102.34947302
12Type I diabetes mellitus_Homo sapiens_hsa049402.26026679
13Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.22450553
14alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.16153919
15Measles_Homo sapiens_hsa051622.11468890
16SNARE interactions in vesicular transport_Homo sapiens_hsa041302.01490696
17Sulfur relay system_Homo sapiens_hsa041221.92398990
18Leishmaniasis_Homo sapiens_hsa051401.61599448
19NOD-like receptor signaling pathway_Homo sapiens_hsa046211.56379386
20B cell receptor signaling pathway_Homo sapiens_hsa046621.55191999
21Osteoclast differentiation_Homo sapiens_hsa043801.47121179
22Linoleic acid metabolism_Homo sapiens_hsa005911.45720594
23Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.45234735
24NF-kappa B signaling pathway_Homo sapiens_hsa040641.39217992
25Drug metabolism - other enzymes_Homo sapiens_hsa009831.39077494
26Chemokine signaling pathway_Homo sapiens_hsa040621.37839564
27Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.31973782
28RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.31369765
29Jak-STAT signaling pathway_Homo sapiens_hsa046301.30501824
30Staphylococcus aureus infection_Homo sapiens_hsa051501.26533735
31Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.24364367
32Pentose phosphate pathway_Homo sapiens_hsa000301.21086429
33Influenza A_Homo sapiens_hsa051641.18632907
34Shigellosis_Homo sapiens_hsa051311.15273360
35Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.13098913
36Viral myocarditis_Homo sapiens_hsa054161.12441273
37Toxoplasmosis_Homo sapiens_hsa051451.04479438
38Phototransduction_Homo sapiens_hsa047441.03591353
39Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.03564666
40Arachidonic acid metabolism_Homo sapiens_hsa005901.03210477
41Leukocyte transendothelial migration_Homo sapiens_hsa046700.99810354
42Caffeine metabolism_Homo sapiens_hsa002320.99327262
43Herpes simplex infection_Homo sapiens_hsa051680.98093680
44Glycerolipid metabolism_Homo sapiens_hsa005610.98023910
45Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.94145926
46Systemic lupus erythematosus_Homo sapiens_hsa053220.92095831
47TNF signaling pathway_Homo sapiens_hsa046680.90806049
48Legionellosis_Homo sapiens_hsa051340.89206470
49Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.84726489
50Apoptosis_Homo sapiens_hsa042100.82965746
51Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.80970022
52Rheumatoid arthritis_Homo sapiens_hsa053230.80044869
53Toll-like receptor signaling pathway_Homo sapiens_hsa046200.80008768
54Malaria_Homo sapiens_hsa051440.77000550
55Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.76429054
56Nitrogen metabolism_Homo sapiens_hsa009100.75940751
57Tuberculosis_Homo sapiens_hsa051520.75410621
58Pyrimidine metabolism_Homo sapiens_hsa002400.70441112
59Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.66939023
60Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.66630833
61Serotonergic synapse_Homo sapiens_hsa047260.65963077
62Transcriptional misregulation in cancer_Homo sapiens_hsa052020.65239785
63Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.59322033
64Proteasome_Homo sapiens_hsa030500.58779860
65Vascular smooth muscle contraction_Homo sapiens_hsa042700.57018690
66Ether lipid metabolism_Homo sapiens_hsa005650.56465672
67Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.53274429
68African trypanosomiasis_Homo sapiens_hsa051430.52656001
69ECM-receptor interaction_Homo sapiens_hsa045120.51982158
70Pertussis_Homo sapiens_hsa051330.48241346
71Olfactory transduction_Homo sapiens_hsa047400.48124469
72Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.47585571
73Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.47231029
74Glycerophospholipid metabolism_Homo sapiens_hsa005640.45738716
75Fat digestion and absorption_Homo sapiens_hsa049750.45137805
76Phospholipase D signaling pathway_Homo sapiens_hsa040720.44733243
77Acute myeloid leukemia_Homo sapiens_hsa052210.41501966
78Epstein-Barr virus infection_Homo sapiens_hsa051690.40792942
79Pancreatic secretion_Homo sapiens_hsa049720.35026505
80Sulfur metabolism_Homo sapiens_hsa009200.34408066
81VEGF signaling pathway_Homo sapiens_hsa043700.34099377
82Phagosome_Homo sapiens_hsa041450.33959823
83Long-term depression_Homo sapiens_hsa047300.33285985
84Viral carcinogenesis_Homo sapiens_hsa052030.32741745
85Hepatitis C_Homo sapiens_hsa051600.31128084
86Renin secretion_Homo sapiens_hsa049240.29925620
87Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.28804326
88Endocytosis_Homo sapiens_hsa041440.27755399
89Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.26687438
90Non-small cell lung cancer_Homo sapiens_hsa052230.25452838
91Collecting duct acid secretion_Homo sapiens_hsa049660.23778270
92Regulation of autophagy_Homo sapiens_hsa041400.23573844
93Purine metabolism_Homo sapiens_hsa002300.23101601
94HTLV-I infection_Homo sapiens_hsa051660.21127062
95Hepatitis B_Homo sapiens_hsa051610.19837827
96Morphine addiction_Homo sapiens_hsa050320.18003683
97Adipocytokine signaling pathway_Homo sapiens_hsa049200.17563121
98Basal transcription factors_Homo sapiens_hsa030220.17166153
99Phosphatidylinositol signaling system_Homo sapiens_hsa040700.16842077
100Thyroid cancer_Homo sapiens_hsa052160.15506562

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