Rank | Gene Set | Z-score |
---|---|---|
1 | nucleotide salvage (GO:0043173) | 6.11108048 |
2 | neutrophil activation involved in immune response (GO:0002283) | 5.67489883 |
3 | activated T cell proliferation (GO:0050798) | 5.63746487 |
4 | nucleoside salvage (GO:0043174) | 5.58534048 |
5 | positive regulation of antigen receptor-mediated signaling pathway (GO:0050857) | 5.43374655 |
6 | negative regulation of thymocyte apoptotic process (GO:0070244) | 5.42368869 |
7 | pyrimidine-containing compound salvage (GO:0008655) | 5.38888708 |
8 | pyrimidine nucleoside salvage (GO:0043097) | 5.38888708 |
9 | regulation of regulatory T cell differentiation (GO:0045589) | 5.10496291 |
10 | negative regulation of T-helper cell differentiation (GO:0045623) | 5.01187033 |
11 | negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371) | 5.01187033 |
12 | negative T cell selection (GO:0043383) | 4.99916357 |
13 | positive regulation of immune response to tumor cell (GO:0002839) | 4.90220924 |
14 | regulation of immune response to tumor cell (GO:0002837) | 4.90220924 |
15 | regulation of response to tumor cell (GO:0002834) | 4.90220924 |
16 | positive regulation of response to tumor cell (GO:0002836) | 4.90220924 |
17 | negative thymic T cell selection (GO:0045060) | 4.81494931 |
18 | purine nucleotide salvage (GO:0032261) | 4.80017501 |
19 | positive regulation of gamma-delta T cell activation (GO:0046645) | 4.75221320 |
20 | pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174) | 4.73076994 |
21 | UMP metabolic process (GO:0046049) | 4.73076994 |
22 | pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173) | 4.73076994 |
23 | UMP biosynthetic process (GO:0006222) | 4.73076994 |
24 | positive regulation of alpha-beta T cell proliferation (GO:0046641) | 4.61710804 |
25 | negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515) | 4.54369493 |
26 | positive regulation of granulocyte differentiation (GO:0030854) | 4.37226065 |
27 | regulation of memory T cell differentiation (GO:0043380) | 4.36781322 |
28 | thrombin receptor signaling pathway (GO:0070493) | 4.19220894 |
29 | regulation of T-helper 1 cell differentiation (GO:0045625) | 4.15287470 |
30 | regulation of alpha-beta T cell proliferation (GO:0046640) | 4.12792165 |
31 | positive regulation of natural killer cell mediated immunity (GO:0002717) | 4.04881048 |
32 | pyrimidine nucleoside monophosphate metabolic process (GO:0009129) | 3.95483480 |
33 | positive regulation of natural killer cell mediated cytotoxicity (GO:0045954) | 3.87849384 |
34 | T cell selection (GO:0045058) | 3.84707327 |
35 | regulation of natural killer cell mediated cytotoxicity (GO:0042269) | 3.81397144 |
36 | regulation of natural killer cell mediated immunity (GO:0002715) | 3.81397144 |
37 | regulation of B cell receptor signaling pathway (GO:0050855) | 3.79149074 |
38 | pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130) | 3.70752705 |
39 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G | 3.69658101 |
40 | regulation of B cell differentiation (GO:0045577) | 3.66091619 |
41 | positive regulation of T cell cytokine production (GO:0002726) | 3.64465549 |
42 | antigen processing and presentation of endogenous peptide antigen (GO:0002483) | 3.57889387 |
43 | regulation of gamma-delta T cell differentiation (GO:0045586) | 3.54256272 |
44 | leukocyte degranulation (GO:0043299) | 3.52883754 |
45 | thymic T cell selection (GO:0045061) | 3.49467209 |
46 | positive regulation of isotype switching (GO:0045830) | 3.48199358 |
47 | neutrophil activation (GO:0042119) | 3.48125071 |
48 | negative regulation of alpha-beta T cell differentiation (GO:0046639) | 3.45061784 |
49 | regulation of T cell receptor signaling pathway (GO:0050856) | 3.44259061 |
50 | positive regulation of DNA recombination (GO:0045911) | 3.41663191 |
51 | regulation of gamma-delta T cell activation (GO:0046643) | 3.41294962 |
52 | regulation of antigen receptor-mediated signaling pathway (GO:0050854) | 3.39435042 |
53 | leukocyte aggregation (GO:0070486) | 3.39107504 |
54 | positive regulation of mast cell activation (GO:0033005) | 3.35862626 |
55 | T cell proliferation (GO:0042098) | 3.34069782 |
56 | regulation of thymocyte apoptotic process (GO:0070243) | 3.33330411 |
57 | positive regulation of macrophage differentiation (GO:0045651) | 3.32028031 |
58 | positive regulation of immunoglobulin mediated immune response (GO:0002891) | 3.27614056 |
59 | positive regulation of B cell mediated immunity (GO:0002714) | 3.27614056 |
60 | negative regulation of T cell apoptotic process (GO:0070233) | 3.26705002 |
61 | Peyers patch development (GO:0048541) | 3.24880022 |
62 | mucosal-associated lymphoid tissue development (GO:0048537) | 3.24880022 |
63 | hepatocyte apoptotic process (GO:0097284) | 3.23879237 |
64 | tolerance induction (GO:0002507) | 3.23488285 |
65 | antigen processing and presentation of endogenous antigen (GO:0019883) | 3.22448871 |
66 | positive T cell selection (GO:0043368) | 3.21919422 |
67 | regulation of platelet aggregation (GO:0090330) | 3.21177446 |
68 | positive regulation of B cell differentiation (GO:0045579) | 3.21172775 |
69 | antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885) | 3.20497171 |
70 | regulation of activation of Janus kinase activity (GO:0010533) | 3.15161469 |
71 | autophagic vacuole fusion (GO:0000046) | 3.12992051 |
72 | positive regulation of leukocyte mediated cytotoxicity (GO:0001912) | 3.11698121 |
73 | positive regulation of interleukin-2 biosynthetic process (GO:0045086) | 3.11004856 |
74 | positive regulation of inflammatory response to antigenic stimulus (GO:0002863) | 3.08156594 |
75 | megakaryocyte development (GO:0035855) | 3.06044487 |
76 | mast cell activation (GO:0045576) | 3.05912370 |
77 | response to interleukin-15 (GO:0070672) | 3.05606119 |
78 | positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372) | 3.05099733 |
79 | angiogenesis involved in wound healing (GO:0060055) | 3.01813031 |
80 | granulocyte activation (GO:0036230) | 3.01116433 |
81 | regulation of B cell mediated immunity (GO:0002712) | 3.00889366 |
82 | dendritic cell chemotaxis (GO:0002407) | 2.99594421 |
83 | positive regulation of interleukin-4 production (GO:0032753) | 2.99284508 |
84 | positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516) | 2.98007270 |
85 | negative regulation of interleukin-17 production (GO:0032700) | 2.96840550 |
86 | G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589) | 2.94447317 |
87 | purine-containing compound salvage (GO:0043101) | 2.91354353 |
88 | positive thymic T cell selection (GO:0045059) | 2.90967786 |
89 | regulation of leukocyte mediated cytotoxicity (GO:0001910) | 2.90684625 |
90 | negative regulation of alpha-beta T cell activation (GO:0046636) | 2.89986871 |
91 | organelle membrane fusion (GO:0090174) | 2.88499842 |
92 | regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370) | 2.87926124 |
93 | regulation of CD4-positive, alpha-beta T cell activation (GO:2000514) | 2.87088032 |
94 | cellular extravasation (GO:0045123) | 2.85837716 |
95 | protein neddylation (GO:0045116) | 2.82485644 |
96 | regulation of RIG-I signaling pathway (GO:0039535) | 2.82334091 |
97 | negative regulation of adaptive immune response based on somatic recombination of immune receptors b | 2.80697177 |
98 | T cell migration (GO:0072678) | 2.80629730 |
99 | regulation of immunoglobulin mediated immune response (GO:0002889) | 2.80497403 |
100 | regulation of T cell cytokine production (GO:0002724) | 2.79820781 |
Rank | Gene Set | Z-score |
---|---|---|
1 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 6.37622007 |
2 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 5.02460300 |
3 | RUNX_20019798_ChIP-Seq_JUKART_Human | 4.08311464 |
4 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 3.82740997 |
5 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 3.47013843 |
6 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 3.46718756 |
7 | MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 3.45831774 |
8 | SCL_19346495_ChIP-Seq_HPC-7_Human | 3.29764072 |
9 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 3.29296233 |
10 | STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 3.01874549 |
11 | MYB_26560356_Chip-Seq_TH2_Human | 2.76745128 |
12 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 2.65526960 |
13 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 2.44444992 |
14 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 2.42707687 |
15 | SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 2.35289123 |
16 | FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse | 2.34634070 |
17 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 2.20531090 |
18 | GATA3_26560356_Chip-Seq_TH2_Human | 2.18689823 |
19 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 2.14975623 |
20 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.13606426 |
21 | UTX_26944678_Chip-Seq_JUKART_Human | 2.05833943 |
22 | IRF8_27001747_Chip-Seq_BMDM_Mouse | 2.04407726 |
23 | GATA3_27048872_Chip-Seq_THYMUS_Human | 2.01892856 |
24 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 2.00919232 |
25 | MYB_26560356_Chip-Seq_TH1_Human | 1.99812228 |
26 | LMO2_20887958_ChIP-Seq_HPC-7_Mouse | 1.96395163 |
27 | SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse | 1.85945891 |
28 | GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.84937739 |
29 | E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 1.78996864 |
30 | SPI1_23547873_ChIP-Seq_NB4_Human | 1.77649167 |
31 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.72201186 |
32 | MAF_26560356_Chip-Seq_TH1_Human | 1.70766963 |
33 | RUNX1_22412390_ChIP-Seq_EML_Mouse | 1.69338039 |
34 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 1.66334109 |
35 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.66330305 |
36 | NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse | 1.62469499 |
37 | SPI1_23127762_ChIP-Seq_K562_Human | 1.60934804 |
38 | GATA2_20887958_ChIP-Seq_HPC-7_Mouse | 1.54406845 |
39 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.53514669 |
40 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 1.52937048 |
41 | PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.44865650 |
42 | VDR_22108803_ChIP-Seq_LS180_Human | 1.41665272 |
43 | PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.41493459 |
44 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.38433212 |
45 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.37483145 |
46 | GATA1_19941826_ChIP-Seq_K562_Human | 1.37481295 |
47 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 1.33521684 |
48 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.33323425 |
49 | GATA2_19941826_ChIP-Seq_K562_Human | 1.31336275 |
50 | GATA1_22383799_ChIP-Seq_G1ME_Mouse | 1.29931145 |
51 | MEIS1_20887958_ChIP-Seq_HPC-7_Mouse | 1.26270943 |
52 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.26243752 |
53 | RUNX1_17652178_ChIP-ChIP_JURKAT_Human | 1.25512463 |
54 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.22298225 |
55 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.21099973 |
56 | TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse | 1.20728023 |
57 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 1.19186417 |
58 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 1.17383590 |
59 | GATA3_26560356_Chip-Seq_TH1_Human | 1.16461245 |
60 | GATA2_22383799_ChIP-Seq_G1ME_Mouse | 1.15341936 |
61 | MYC_22102868_ChIP-Seq_BL_Human | 1.14287598 |
62 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.13793409 |
63 | BRD4_27068464_Chip-Seq_AML-cells_Mouse | 1.13528838 |
64 | HTT_18923047_ChIP-ChIP_STHdh_Human | 1.12483080 |
65 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.11637127 |
66 | PU_27001747_Chip-Seq_BMDM_Mouse | 1.10791595 |
67 | VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human | 1.10396284 |
68 | GATA1_22025678_ChIP-Seq_K562_Human | 1.09985930 |
69 | MAF_26560356_Chip-Seq_TH2_Human | 1.09345890 |
70 | GATA2_21666600_ChIP-Seq_HMVEC_Human | 1.07148544 |
71 | Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse | 1.06529737 |
72 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.06022754 |
73 | SALL4_22934838_ChIP-ChIP_CD34+_Human | 1.04918597 |
74 | KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse | 1.03435053 |
75 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.02027021 |
76 | TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.00375578 |
77 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 0.98829933 |
78 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 0.97751033 |
79 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 0.97714304 |
80 | CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse | 0.97005116 |
81 | ER_23166858_ChIP-Seq_MCF-7_Human | 0.96067636 |
82 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.95578212 |
83 | VDR_24763502_ChIP-Seq_THP-1_Human | 0.95155692 |
84 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 0.93468573 |
85 | CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse | 0.91261899 |
86 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.91224398 |
87 | VDR_24787735_ChIP-Seq_THP-1_Human | 0.88549028 |
88 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.87699334 |
89 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 0.86445190 |
90 | TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.86067903 |
91 | GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.85830509 |
92 | CRX_20693478_ChIP-Seq_RETINA_Mouse | 0.85001468 |
93 | GATA3_21878914_ChIP-Seq_MCF-7_Human | 0.84725385 |
94 | GATA1_19941827_ChIP-Seq_MEL86_Mouse | 0.84561052 |
95 | SPI1_20517297_ChIP-Seq_HL60_Human | 0.83974266 |
96 | OCT4_21477851_ChIP-Seq_ESCs_Mouse | 0.82338644 |
97 | VDR_23849224_ChIP-Seq_CD4+_Human | 0.82004771 |
98 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 0.81650986 |
99 | SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse | 0.80546913 |
100 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 0.79196214 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0005464_abnormal_platelet_physiology | 4.85195057 |
2 | MP0003724_increased_susceptibility_to | 4.21456836 |
3 | MP0001835_abnormal_antigen_presentation | 3.83557340 |
4 | MP0005671_abnormal_response_to | 3.42028522 |
5 | MP0002163_abnormal_gland_morphology | 3.31205632 |
6 | MP0003763_abnormal_thymus_physiology | 3.22621220 |
7 | MP0005000_abnormal_immune_tolerance | 2.88976105 |
8 | MP0001790_abnormal_immune_system | 2.83587138 |
9 | MP0005387_immune_system_phenotype | 2.83587138 |
10 | MP0002148_abnormal_hypersensitivity_rea | 2.75079832 |
11 | MP0003436_decreased_susceptibility_to | 2.46203861 |
12 | MP0000685_abnormal_immune_system | 2.38231722 |
13 | MP0001800_abnormal_humoral_immune | 2.37484761 |
14 | MP0010155_abnormal_intestine_physiology | 2.27387948 |
15 | MP0008004_abnormal_stomach_pH | 2.25327035 |
16 | MP0002723_abnormal_immune_serum | 2.22765180 |
17 | MP0000465_gastrointestinal_hemorrhage | 2.13592833 |
18 | MP0002398_abnormal_bone_marrow | 2.10900481 |
19 | MP0002420_abnormal_adaptive_immunity | 2.10102005 |
20 | MP0001819_abnormal_immune_cell | 2.06060295 |
21 | MP0008872_abnormal_physiological_respon | 2.05196823 |
22 | MP0009333_abnormal_splenocyte_physiolog | 2.04679577 |
23 | MP0003183_abnormal_peptide_metabolism | 2.04262791 |
24 | MP0005167_abnormal_blood-brain_barrier | 2.03683632 |
25 | MP0002452_abnormal_antigen_presenting | 2.02781241 |
26 | MP0000703_abnormal_thymus_morphology | 1.92190260 |
27 | MP0001873_stomach_inflammation | 1.88972605 |
28 | MP0005025_abnormal_response_to | 1.87622481 |
29 | MP0009785_altered_susceptibility_to | 1.87250907 |
30 | MP0002166_altered_tumor_susceptibility | 1.85870915 |
31 | MP0003300_gastrointestinal_ulcer | 1.83494618 |
32 | MP0005379_endocrine/exocrine_gland_phen | 1.82951944 |
33 | MP0005670_abnormal_white_adipose | 1.80074727 |
34 | MP0000716_abnormal_immune_system | 1.77318624 |
35 | MP0008961_abnormal_basal_metabolism | 1.76887814 |
36 | MP0000689_abnormal_spleen_morphology | 1.76879328 |
37 | MP0002722_abnormal_immune_system | 1.72463113 |
38 | MP0006082_CNS_inflammation | 1.71865713 |
39 | MP0004947_skin_inflammation | 1.70306284 |
40 | MP0002419_abnormal_innate_immunity | 1.69692642 |
41 | MP0003866_abnormal_defecation | 1.67022617 |
42 | MP0004381_abnormal_hair_follicle | 1.62805727 |
43 | MP0002429_abnormal_blood_cell | 1.53860304 |
44 | MP0005645_abnormal_hypothalamus_physiol | 1.50362694 |
45 | MP0001845_abnormal_inflammatory_respons | 1.49057668 |
46 | MP0005310_abnormal_salivary_gland | 1.48392834 |
47 | MP0003303_peritoneal_inflammation | 1.48324426 |
48 | MP0004084_abnormal_cardiac_muscle | 1.47864409 |
49 | MP0002132_abnormal_respiratory_system | 1.43242508 |
50 | MP0002405_respiratory_system_inflammati | 1.41133693 |
51 | MP0001663_abnormal_digestive_system | 1.39468301 |
52 | MP0001533_abnormal_skeleton_physiology | 1.31420363 |
53 | MP0004510_myositis | 1.30755697 |
54 | MP0001348_abnormal_lacrimal_gland | 1.24520553 |
55 | MP0002006_tumorigenesis | 1.22575273 |
56 | MP0004036_abnormal_muscle_relaxation | 1.12328473 |
57 | MP0009764_decreased_sensitivity_to | 1.10354969 |
58 | MP0009763_increased_sensitivity_to | 1.04284099 |
59 | MP0005410_abnormal_fertilization | 1.01586228 |
60 | MP0005084_abnormal_gallbladder_morpholo | 1.00439867 |
61 | MP0005075_abnormal_melanosome_morpholog | 0.93342559 |
62 | MP0000249_abnormal_blood_vessel | 0.89361765 |
63 | MP0003806_abnormal_nucleotide_metabolis | 0.89233253 |
64 | MP0003638_abnormal_response/metabolism_ | 0.87658065 |
65 | MP0002998_abnormal_bone_remodeling | 0.87248283 |
66 | MP0001765_abnormal_ion_homeostasis | 0.86358948 |
67 | MP0008469_abnormal_protein_level | 0.86002423 |
68 | MP0001851_eye_inflammation | 0.85024029 |
69 | MP0008775_abnormal_heart_ventricle | 0.81715017 |
70 | MP0004215_abnormal_myocardial_fiber | 0.79092901 |
71 | MP0009697_abnormal_copulation | 0.77323218 |
72 | MP0005381_digestive/alimentary_phenotyp | 0.76738988 |
73 | MP0010329_abnormal_lipoprotein_level | 0.76715858 |
74 | MP0008875_abnormal_xenobiotic_pharmacok | 0.75622068 |
75 | MP0003656_abnormal_erythrocyte_physiolo | 0.74976718 |
76 | MP0000383_abnormal_hair_follicle | 0.74558302 |
77 | MP0000230_abnormal_systemic_arterial | 0.73445978 |
78 | MP0000858_altered_metastatic_potential | 0.72980511 |
79 | MP0008873_increased_physiological_sensi | 0.72810098 |
80 | MP0009765_abnormal_xenobiotic_induced | 0.69766820 |
81 | MP0004808_abnormal_hematopoietic_stem | 0.69723810 |
82 | MP0001968_abnormal_touch/_nociception | 0.67068227 |
83 | MP0000569_abnormal_digit_pigmentation | 0.66875359 |
84 | MP0002396_abnormal_hematopoietic_system | 0.65904523 |
85 | MP0001666_abnormal_nutrient_absorption | 0.65354552 |
86 | MP0002693_abnormal_pancreas_physiology | 0.65001020 |
87 | MP0000490_abnormal_crypts_of | 0.64879877 |
88 | MP0000343_altered_response_to | 0.62497010 |
89 | MP0009642_abnormal_blood_homeostasis | 0.60645688 |
90 | MP0001905_abnormal_dopamine_level | 0.60376955 |
91 | MP0002019_abnormal_tumor_incidence | 0.60313194 |
92 | MP0002138_abnormal_hepatobiliary_system | 0.59639538 |
93 | MP0001346_abnormal_lacrimal_gland | 0.59195248 |
94 | MP0002933_joint_inflammation | 0.58888054 |
95 | MP0002733_abnormal_thermal_nociception | 0.58466940 |
96 | MP0004883_abnormal_blood_vessel | 0.57354770 |
97 | MP0001853_heart_inflammation | 0.54315597 |
98 | MP0005448_abnormal_energy_balance | 0.53122803 |
99 | MP0003950_abnormal_plasma_membrane | 0.52590066 |
100 | MP0003646_muscle_fatigue | 0.51048382 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Prolonged bleeding time (HP:0003010) | 6.95686913 |
2 | Menorrhagia (HP:0000132) | 5.54145040 |
3 | Petechiae (HP:0000967) | 5.41973157 |
4 | Increased mean platelet volume (HP:0011877) | 5.25288626 |
5 | Autoimmune hemolytic anemia (HP:0001890) | 5.14533506 |
6 | Epistaxis (HP:0000421) | 5.13259679 |
7 | Abnormal platelet volume (HP:0011876) | 5.12902809 |
8 | Stomatitis (HP:0010280) | 5.02425233 |
9 | Purpura (HP:0000979) | 4.82672243 |
10 | Gingival bleeding (HP:0000225) | 4.65559579 |
11 | Panhypogammaglobulinemia (HP:0003139) | 4.37447696 |
12 | Autoimmune thrombocytopenia (HP:0001973) | 4.33667430 |
13 | Abnormal delayed hypersensitivity skin test (HP:0002963) | 4.33557308 |
14 | Elevated erythrocyte sedimentation rate (HP:0003565) | 3.90808642 |
15 | Papilledema (HP:0001085) | 3.52882907 |
16 | Increased IgM level (HP:0003496) | 3.51631224 |
17 | Congenital, generalized hypertrichosis (HP:0004540) | 3.48908005 |
18 | Eosinophilia (HP:0001880) | 3.41401323 |
19 | Mediastinal lymphadenopathy (HP:0100721) | 3.39276218 |
20 | Impaired platelet aggregation (HP:0003540) | 3.28634464 |
21 | Abnormal platelet function (HP:0011869) | 3.28634464 |
22 | Abnormality of B cell number (HP:0010975) | 3.26164718 |
23 | Encephalitis (HP:0002383) | 3.25266740 |
24 | Hip dysplasia (HP:0001385) | 3.17058169 |
25 | Abnormality of T cell number (HP:0011839) | 3.12453638 |
26 | Granulocytopenia (HP:0001913) | 3.12117504 |
27 | IgG deficiency (HP:0004315) | 3.08420554 |
28 | B lymphocytopenia (HP:0010976) | 3.06446064 |
29 | Arterial thrombosis (HP:0004420) | 3.02426618 |
30 | Difficulty running (HP:0009046) | 3.00460620 |
31 | Myositis (HP:0100614) | 2.88434047 |
32 | Abnormality of eosinophils (HP:0001879) | 2.87583909 |
33 | Pulmonary infiltrates (HP:0002113) | 2.86086267 |
34 | Abnormality of T cells (HP:0002843) | 2.85684594 |
35 | Agammaglobulinemia (HP:0004432) | 2.85338001 |
36 | Recurrent viral infections (HP:0004429) | 2.79794868 |
37 | Abnormality of the pons (HP:0007361) | 2.79264657 |
38 | Abnormality of T cell physiology (HP:0011840) | 2.76987638 |
39 | Hyperlipoproteinemia (HP:0010980) | 2.76918024 |
40 | Meningitis (HP:0001287) | 2.74891308 |
41 | Abnormality of the prostate (HP:0008775) | 2.72823605 |
42 | T lymphocytopenia (HP:0005403) | 2.70070084 |
43 | Chest pain (HP:0100749) | 2.69871270 |
44 | Recurrent fungal infections (HP:0002841) | 2.66976935 |
45 | Optic neuritis (HP:0100653) | 2.66558054 |
46 | Retrobulbar optic neuritis (HP:0100654) | 2.66558054 |
47 | Gastrointestinal infarctions (HP:0005244) | 2.66249623 |
48 | Spontaneous hematomas (HP:0007420) | 2.65928490 |
49 | Joint swelling (HP:0001386) | 2.61468516 |
50 | Leukocytosis (HP:0001974) | 2.60599874 |
51 | Recurrent cutaneous fungal infections (HP:0011370) | 2.49762208 |
52 | Chronic mucocutaneous candidiasis (HP:0002728) | 2.49762208 |
53 | Thrombocytosis (HP:0001894) | 2.49075031 |
54 | Episodic fever (HP:0001954) | 2.44493319 |
55 | Chronic otitis media (HP:0000389) | 2.43898609 |
56 | Abnormal pupillary function (HP:0007686) | 2.37116750 |
57 | Severe combined immunodeficiency (HP:0004430) | 2.35923985 |
58 | Hypoproteinemia (HP:0003075) | 2.34144079 |
59 | Orchitis (HP:0100796) | 2.30690962 |
60 | Abnormality of the common coagulation pathway (HP:0010990) | 2.29925645 |
61 | Poikilocytosis (HP:0004447) | 2.27763657 |
62 | Thyroiditis (HP:0100646) | 2.26125773 |
63 | Recurrent bacterial skin infections (HP:0005406) | 2.22227991 |
64 | Exertional dyspnea (HP:0002875) | 2.20650968 |
65 | Vasculitis (HP:0002633) | 2.19723849 |
66 | Bruising susceptibility (HP:0000978) | 2.18506970 |
67 | Hypoplasia of the pons (HP:0012110) | 2.17566049 |
68 | Dry hair (HP:0011359) | 2.15746310 |
69 | Pustule (HP:0200039) | 2.15122571 |
70 | Amaurosis fugax (HP:0100576) | 2.13094155 |
71 | Asplenia (HP:0001746) | 2.13067660 |
72 | Hypokalemic alkalosis (HP:0001949) | 2.11984282 |
73 | Acanthocytosis (HP:0001927) | 2.11014551 |
74 | Obstructive lung disease (HP:0006536) | 2.10829817 |
75 | Chronic obstructive pulmonary disease (HP:0006510) | 2.10829817 |
76 | Gangrene (HP:0100758) | 2.09951340 |
77 | Aplasia/Hypoplasia of the spleen (HP:0010451) | 2.09647508 |
78 | Abnormality of macrophages (HP:0004311) | 2.09286673 |
79 | Recurrent skin infections (HP:0001581) | 2.07686380 |
80 | Fatigue (HP:0012378) | 2.07090986 |
81 | Recurrent abscess formation (HP:0002722) | 2.02642645 |
82 | Fair hair (HP:0002286) | 2.00085905 |
83 | Abnormality of cells of the lymphoid lineage (HP:0012140) | 1.99584615 |
84 | Abnormality of the fingertips (HP:0001211) | 1.97473791 |
85 | Keratoconjunctivitis sicca (HP:0001097) | 1.95374715 |
86 | Increased IgE level (HP:0003212) | 1.94972694 |
87 | Hypergammaglobulinemia (HP:0010702) | 1.92229868 |
88 | Keratoconjunctivitis (HP:0001096) | 1.88278731 |
89 | Lymphopenia (HP:0001888) | 1.88069439 |
90 | Dyschromatopsia (HP:0007641) | 1.87719088 |
91 | Congenital stationary night blindness (HP:0007642) | 1.87461789 |
92 | IgA deficiency (HP:0002720) | 1.84103657 |
93 | Mesangial abnormality (HP:0001966) | 1.83295361 |
94 | Pulmonary embolism (HP:0002204) | 1.83006468 |
95 | Chronic diarrhea (HP:0002028) | 1.82583640 |
96 | Abnormality of the renal cortex (HP:0011035) | 1.81305870 |
97 | Spondylolisthesis (HP:0003302) | 1.80911860 |
98 | Abnormality of the anterior horn cell (HP:0006802) | 1.80705304 |
99 | Degeneration of anterior horn cells (HP:0002398) | 1.80705304 |
100 | Abnormality of the Achilles tendon (HP:0005109) | 1.79941972 |
Rank | Gene Set | Z-score |
---|---|---|
1 | EIF2AK1 | 4.89610514 |
2 | MST4 | 4.20987193 |
3 | RIPK4 | 3.97670125 |
4 | MAP4K1 | 3.57188279 |
5 | TEC | 3.48837012 |
6 | TXK | 3.20576595 |
7 | PIK3CG | 3.05111203 |
8 | ITK | 2.41894664 |
9 | BTK | 2.41585323 |
10 | SYK | 2.30038283 |
11 | BMPR2 | 2.24559123 |
12 | TAOK3 | 2.23090229 |
13 | CAMKK2 | 2.18799586 |
14 | FES | 2.16320175 |
15 | CSF1R | 2.10254795 |
16 | MAP2K6 | 1.93912458 |
17 | NLK | 1.86039537 |
18 | STK24 | 1.77895618 |
19 | MYLK | 1.73753445 |
20 | FRK | 1.69140764 |
21 | ZAP70 | 1.67545455 |
22 | MAPKAPK3 | 1.64266810 |
23 | GRK6 | 1.52108028 |
24 | ADRBK2 | 1.49931572 |
25 | LCK | 1.44697839 |
26 | EIF2AK3 | 1.44475998 |
27 | JAK3 | 1.43910173 |
28 | HCK | 1.43470879 |
29 | IKBKB | 1.36006410 |
30 | LYN | 1.28829946 |
31 | TNK2 | 1.13468725 |
32 | MAP3K14 | 1.07260083 |
33 | STK3 | 1.06731959 |
34 | BMX | 1.04880674 |
35 | TSSK6 | 1.03904925 |
36 | MAP3K13 | 1.02764463 |
37 | KIT | 1.01626518 |
38 | ZAK | 0.98344011 |
39 | IKBKE | 0.98008494 |
40 | PDK1 | 0.96868843 |
41 | STK16 | 0.96865184 |
42 | GRK5 | 0.95773640 |
43 | IRAK1 | 0.92168169 |
44 | STK39 | 0.91807555 |
45 | PTK2B | 0.88495264 |
46 | WNK4 | 0.87036077 |
47 | CAMKK1 | 0.85058350 |
48 | CSK | 0.80575865 |
49 | TLK1 | 0.80203037 |
50 | PRKCQ | 0.78913327 |
51 | MAPK11 | 0.75304254 |
52 | FLT3 | 0.73284223 |
53 | TAOK2 | 0.71754601 |
54 | MAP2K3 | 0.67073588 |
55 | PLK2 | 0.65688097 |
56 | STK38L | 0.64655858 |
57 | SGK2 | 0.62482768 |
58 | BLK | 0.62267997 |
59 | BMPR1B | 0.60242594 |
60 | JAK1 | 0.58312535 |
61 | TAOK1 | 0.55849647 |
62 | PASK | 0.55301992 |
63 | IRAK4 | 0.54671146 |
64 | JAK2 | 0.53281608 |
65 | IGF1R | 0.51611302 |
66 | BCR | 0.50290386 |
67 | ADRBK1 | 0.49152093 |
68 | HIPK2 | 0.48059160 |
69 | MAPKAPK2 | 0.46795680 |
70 | IRAK3 | 0.45769037 |
71 | PRPF4B | 0.45237541 |
72 | LIMK1 | 0.44865421 |
73 | CLK1 | 0.43515091 |
74 | OXSR1 | 0.43290978 |
75 | MAP3K5 | 0.41915241 |
76 | MAPK13 | 0.38319126 |
77 | SIK3 | 0.38282835 |
78 | FGFR3 | 0.38259622 |
79 | GRK1 | 0.36592360 |
80 | NUAK1 | 0.34696223 |
81 | FYN | 0.34626267 |
82 | MAP3K11 | 0.34527387 |
83 | PKN1 | 0.34270499 |
84 | EIF2AK2 | 0.31971098 |
85 | PRKCB | 0.31603796 |
86 | PRKCD | 0.31132057 |
87 | PRKCH | 0.31107331 |
88 | SGK3 | 0.29381295 |
89 | MATK | 0.28695920 |
90 | PIM1 | 0.28374366 |
91 | PRKCA | 0.27706317 |
92 | ACVR1B | 0.27536466 |
93 | PDPK1 | 0.27236147 |
94 | EPHA3 | 0.27198173 |
95 | MAP3K3 | 0.26750741 |
96 | MAP3K12 | 0.25742533 |
97 | TBK1 | 0.25333567 |
98 | MAPK12 | 0.24489480 |
99 | MARK3 | 0.23139131 |
100 | TNIK | 0.22902154 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Graft-versus-host disease_Homo sapiens_hsa05332 | 4.22720190 |
2 | Primary immunodeficiency_Homo sapiens_hsa05340 | 3.92019760 |
3 | Allograft rejection_Homo sapiens_hsa05330 | 3.33934719 |
4 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 3.16756067 |
5 | Platelet activation_Homo sapiens_hsa04611 | 3.07569553 |
6 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 2.98111572 |
7 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 2.68006169 |
8 | Antigen processing and presentation_Homo sapiens_hsa04612 | 2.55394097 |
9 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 2.48587529 |
10 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 2.41173099 |
11 | Asthma_Homo sapiens_hsa05310 | 2.34947302 |
12 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 2.26026679 |
13 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 2.22450553 |
14 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 2.16153919 |
15 | Measles_Homo sapiens_hsa05162 | 2.11468890 |
16 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 2.01490696 |
17 | Sulfur relay system_Homo sapiens_hsa04122 | 1.92398990 |
18 | Leishmaniasis_Homo sapiens_hsa05140 | 1.61599448 |
19 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 1.56379386 |
20 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 1.55191999 |
21 | Osteoclast differentiation_Homo sapiens_hsa04380 | 1.47121179 |
22 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 1.45720594 |
23 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 1.45234735 |
24 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 1.39217992 |
25 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 1.39077494 |
26 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 1.37839564 |
27 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 1.31973782 |
28 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 1.31369765 |
29 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 1.30501824 |
30 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 1.26533735 |
31 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 1.24364367 |
32 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 1.21086429 |
33 | Influenza A_Homo sapiens_hsa05164 | 1.18632907 |
34 | Shigellosis_Homo sapiens_hsa05131 | 1.15273360 |
35 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.13098913 |
36 | Viral myocarditis_Homo sapiens_hsa05416 | 1.12441273 |
37 | Toxoplasmosis_Homo sapiens_hsa05145 | 1.04479438 |
38 | Phototransduction_Homo sapiens_hsa04744 | 1.03591353 |
39 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 1.03564666 |
40 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 1.03210477 |
41 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 0.99810354 |
42 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.99327262 |
43 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.98093680 |
44 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.98023910 |
45 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.94145926 |
46 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.92095831 |
47 | TNF signaling pathway_Homo sapiens_hsa04668 | 0.90806049 |
48 | Legionellosis_Homo sapiens_hsa05134 | 0.89206470 |
49 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 0.84726489 |
50 | Apoptosis_Homo sapiens_hsa04210 | 0.82965746 |
51 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.80970022 |
52 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.80044869 |
53 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 0.80008768 |
54 | Malaria_Homo sapiens_hsa05144 | 0.77000550 |
55 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.76429054 |
56 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.75940751 |
57 | Tuberculosis_Homo sapiens_hsa05152 | 0.75410621 |
58 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 0.70441112 |
59 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.66939023 |
60 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.66630833 |
61 | Serotonergic synapse_Homo sapiens_hsa04726 | 0.65963077 |
62 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.65239785 |
63 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 0.59322033 |
64 | Proteasome_Homo sapiens_hsa03050 | 0.58779860 |
65 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.57018690 |
66 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.56465672 |
67 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.53274429 |
68 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.52656001 |
69 | ECM-receptor interaction_Homo sapiens_hsa04512 | 0.51982158 |
70 | Pertussis_Homo sapiens_hsa05133 | 0.48241346 |
71 | Olfactory transduction_Homo sapiens_hsa04740 | 0.48124469 |
72 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.47585571 |
73 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.47231029 |
74 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.45738716 |
75 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.45137805 |
76 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.44733243 |
77 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.41501966 |
78 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.40792942 |
79 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.35026505 |
80 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.34408066 |
81 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.34099377 |
82 | Phagosome_Homo sapiens_hsa04145 | 0.33959823 |
83 | Long-term depression_Homo sapiens_hsa04730 | 0.33285985 |
84 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.32741745 |
85 | Hepatitis C_Homo sapiens_hsa05160 | 0.31128084 |
86 | Renin secretion_Homo sapiens_hsa04924 | 0.29925620 |
87 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.28804326 |
88 | Endocytosis_Homo sapiens_hsa04144 | 0.27755399 |
89 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.26687438 |
90 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.25452838 |
91 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.23778270 |
92 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.23573844 |
93 | Purine metabolism_Homo sapiens_hsa00230 | 0.23101601 |
94 | HTLV-I infection_Homo sapiens_hsa05166 | 0.21127062 |
95 | Hepatitis B_Homo sapiens_hsa05161 | 0.19837827 |
96 | Morphine addiction_Homo sapiens_hsa05032 | 0.18003683 |
97 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.17563121 |
98 | Basal transcription factors_Homo sapiens_hsa03022 | 0.17166153 |
99 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.16842077 |
100 | Thyroid cancer_Homo sapiens_hsa05216 | 0.15506562 |