TRBV4-1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cell killing (GO:0031342)7.00196265
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)7.00196265
3antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.96832331
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.67835441
5positive regulation of gamma-delta T cell activation (GO:0046645)6.56913078
6negative T cell selection (GO:0043383)6.16780719
7antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.14582922
8regulation of regulatory T cell differentiation (GO:0045589)6.11708271
9positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)6.03928190
10antigen processing and presentation of endogenous antigen (GO:0019883)6.03328887
11negative thymic T cell selection (GO:0045060)6.01841113
12tolerance induction (GO:0002507)5.61889646
13cellular response to interleukin-15 (GO:0071350)5.52890278
14response to interleukin-15 (GO:0070672)5.52549578
15regulation of B cell receptor signaling pathway (GO:0050855)5.14439645
16regulation of T cell tolerance induction (GO:0002664)5.07308952
17positive regulation of interleukin-2 biosynthetic process (GO:0045086)5.06097239
18regulation of gamma-delta T cell differentiation (GO:0045586)5.05740018
19activated T cell proliferation (GO:0050798)5.01856231
20thymic T cell selection (GO:0045061)4.95940197
21positive thymic T cell selection (GO:0045059)4.83521454
22regulation of gamma-delta T cell activation (GO:0046643)4.82749458
23positive T cell selection (GO:0043368)4.79863318
24regulation of isotype switching to IgG isotypes (GO:0048302)4.78762950
25leukocyte aggregation (GO:0070486)4.76231059
26T cell migration (GO:0072678)4.73303151
27T cell selection (GO:0045058)4.68371487
28negative regulation of T cell mediated immunity (GO:0002710)4.47711293
29regulation of natural killer cell mediated immunity (GO:0002715)4.43615668
30regulation of natural killer cell mediated cytotoxicity (GO:0042269)4.43615668
31positive regulation of tolerance induction (GO:0002645)4.34750089
32positive regulation of granulocyte differentiation (GO:0030854)4.31359767
33regulation of tolerance induction (GO:0002643)4.28393118
34regulation of alpha-beta T cell proliferation (GO:0046640)4.27511236
35negative regulation of lymphocyte mediated immunity (GO:0002707)4.26866235
36regulation of interleukin-2 biosynthetic process (GO:0045076)4.02755301
37regulation of T cell mediated cytotoxicity (GO:0001914)3.91768830
38antigen processing and presentation via MHC class Ib (GO:0002475)3.91173351
39positive regulation of T cell mediated cytotoxicity (GO:0001916)3.88833673
40positive regulation of alpha-beta T cell proliferation (GO:0046641)3.85279440
41T cell receptor signaling pathway (GO:0050852)3.84813644
42positive regulation of natural killer cell mediated immunity (GO:0002717)3.83248757
43positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.81722455
44regulation of leukocyte mediated cytotoxicity (GO:0001910)3.77656938
45cellular extravasation (GO:0045123)3.75406545
46positive regulation of B cell differentiation (GO:0045579)3.71256643
47detection of bacterium (GO:0016045)3.70554428
48regulation of B cell differentiation (GO:0045577)3.67236776
49negative regulation of leukocyte mediated immunity (GO:0002704)3.65323503
50antigen receptor-mediated signaling pathway (GO:0050851)3.65240063
51regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.61889127
52cellular response to type I interferon (GO:0071357)3.60155890
53type I interferon signaling pathway (GO:0060337)3.60155890
54detection of other organism (GO:0098543)3.57383949
55response to type I interferon (GO:0034340)3.56611575
56T cell homeostasis (GO:0043029)3.55719244
57respiratory burst (GO:0045730)3.52081831
58negative regulation of interleukin-12 production (GO:0032695)3.51237101
59negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.49981134
60positive regulation of isotype switching (GO:0045830)3.49122859
61positive regulation of cell killing (GO:0031343)3.43874395
62regulation of cell killing (GO:0031341)3.41584654
63interferon-gamma production (GO:0032609)3.41401366
64mast cell activation (GO:0045576)3.38391409
65positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.38315854
66neutrophil activation involved in immune response (GO:0002283)3.37150976
67negative regulation of phagocytosis (GO:0050765)3.35045367
68positive regulation of interleukin-4 production (GO:0032753)3.33730060
69alpha-beta T cell differentiation (GO:0046632)3.32555967
70positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.32078674
71myeloid dendritic cell differentiation (GO:0043011)3.29951041
72regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.25015016
73positive regulation of humoral immune response (GO:0002922)3.23067325
74T cell costimulation (GO:0031295)3.21754758
75lymphocyte costimulation (GO:0031294)3.18391923
76positive regulation by symbiont of host defense response (GO:0052509)3.16170258
77modulation by symbiont of host defense response (GO:0052031)3.16170258
78modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.16170258
79modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.16170258
80positive regulation by organism of defense response of other organism involved in symbiotic interact3.16170258
81modulation by symbiont of host immune response (GO:0052553)3.16170258
82positive regulation of DNA recombination (GO:0045911)3.15731811
83positive regulation of interleukin-2 production (GO:0032743)3.15443941
84myeloid dendritic cell activation (GO:0001773)3.14970094
85regulation of isotype switching (GO:0045191)3.12690297
86dendritic cell chemotaxis (GO:0002407)3.12454126
87lymphocyte migration (GO:0072676)3.11971484
88positive regulation of T cell differentiation in thymus (GO:0033089)3.11635253
89positive regulation of lymphocyte mediated immunity (GO:0002708)3.10481194
90positive regulation of T cell mediated immunity (GO:0002711)3.09662563
91NIK/NF-kappaB signaling (GO:0038061)3.09262529
92negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.08974250
93B cell receptor signaling pathway (GO:0050853)3.07109012
94negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.06932871
95negative regulation of T-helper cell differentiation (GO:0045623)3.06932871
96alpha-beta T cell activation (GO:0046631)3.05519383
97regulation of alpha-beta T cell activation (GO:0046634)3.05063477
98regulation of T cell receptor signaling pathway (GO:0050856)3.04854931
99regulation of T cell mediated immunity (GO:0002709)3.01881448
100T cell differentiation (GO:0030217)3.01496639

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse6.14086989
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human6.07763856
3IRF8_22096565_ChIP-ChIP_GC-B_Human5.29650934
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.90371264
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.76753782
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.63573822
7RUNX_20019798_ChIP-Seq_JUKART_Human3.63040976
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.44698764
9MYB_26560356_Chip-Seq_TH2_Human3.40594324
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.37801619
11STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.28189288
12STAT4_19710469_ChIP-ChIP_TH1__Mouse2.98166624
13MAF_26560356_Chip-Seq_TH1_Human2.94839123
14FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.83747939
15SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.82673376
16MYB_26560356_Chip-Seq_TH1_Human2.78483198
17ELF1_17652178_ChIP-ChIP_JURKAT_Human2.78078872
18SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.68546030
19UTX_26944678_Chip-Seq_JUKART_Human2.68318389
20RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.54225402
21SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.49134842
22SPI1_23547873_ChIP-Seq_NB4_Human2.45395032
23MAF_26560356_Chip-Seq_TH2_Human2.35857007
24MYC_22102868_ChIP-Seq_BL_Human2.33326169
25GATA3_27048872_Chip-Seq_THYMUS_Human2.29687104
26IRF8_27001747_Chip-Seq_BMDM_Mouse2.28964289
27VDR_21846776_ChIP-Seq_THP-1_Human2.19488414
28NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.17825565
29E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.09081889
30MYB_21317192_ChIP-Seq_ERMYB_Mouse2.05752260
31NOTCH1_21737748_ChIP-Seq_TLL_Human2.04966203
32VDR_24763502_ChIP-Seq_THP-1_Human2.00471266
33SCL_19346495_ChIP-Seq_HPC-7_Human1.98678784
34RUNX1_22412390_ChIP-Seq_EML_Mouse1.97086027
35MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.91210683
36FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.90675250
37SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.89663264
38SPI1_23127762_ChIP-Seq_K562_Human1.85262432
39GATA3_26560356_Chip-Seq_TH2_Human1.76594240
40BRD4_27068464_Chip-Seq_AML-cells_Mouse1.72638588
41SMAD_19615063_ChIP-ChIP_OVARY_Human1.71542114
42TCF7_22412390_ChIP-Seq_EML_Mouse1.59104149
43LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.55595803
44KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.54756890
45STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.52652564
46VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.45969582
47CIITA_25753668_ChIP-Seq_RAJI_Human1.44685546
48LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.44443526
49RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.43456990
50KDM2B_26808549_Chip-Seq_DND41_Human1.42125992
51ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.33785952
52RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.33525910
53TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.31534272
54KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.31061161
55SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.28792327
56KDM2B_26808549_Chip-Seq_SUP-B15_Human1.26728463
57CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.26583282
58CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.22768244
59NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.21808404
60CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.20577336
61GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.20346952
62GATA2_22383799_ChIP-Seq_G1ME_Mouse1.17438792
63EGR1_19374776_ChIP-ChIP_THP-1_Human1.17347619
64CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15518744
65BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.13906669
66E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.12650102
67TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.11775580
68PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11519710
69VDR_23849224_ChIP-Seq_CD4+_Human1.10400020
70PU_27001747_Chip-Seq_BMDM_Mouse1.10029258
71VDR_24787735_ChIP-Seq_THP-1_Human1.09430943
72GATA1_19941827_ChIP-Seq_MEL_Mouse1.08481977
73PU.1_20513432_ChIP-Seq_Bcells_Mouse1.08291807
74PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07993893
75KDM2B_26808549_Chip-Seq_JURKAT_Human1.06465864
76PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05073706
77NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.02438653
78GATA1_22383799_ChIP-Seq_G1ME_Mouse1.01572584
79THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.01112812
80SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00762937
81TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98813036
82FOXP3_21729870_ChIP-Seq_TREG_Human0.95834065
83FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95259804
84BCL6_27268052_Chip-Seq_Bcells_Human0.94765848
85PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.92167323
86GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89450427
87CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.89004413
88ELK3_25401928_ChIP-Seq_HUVEC_Human0.87070677
89Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.85377642
90GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85284345
91RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80809106
92HOXB4_20404135_ChIP-ChIP_EML_Mouse0.79826270
93BCOR_27268052_Chip-Seq_Bcells_Human0.79746969
94CTCF_27219007_Chip-Seq_ERYTHROID_Human0.78216029
95ELF1_20517297_ChIP-Seq_JURKAT_Human0.75075684
96GATA1_19941826_ChIP-Seq_K562_Human0.72638386
97SPI1_20517297_ChIP-Seq_HL60_Human0.71531823
98NCOR1_26117541_ChIP-Seq_K562_Human0.71111376
99GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.70201710
100SMRT_27268052_Chip-Seq_Bcells_Human0.69818129

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.54061389
2MP0003763_abnormal_thymus_physiology4.36706260
3MP0003436_decreased_susceptibility_to4.00380991
4MP0001835_abnormal_antigen_presentation4.00038265
5MP0001800_abnormal_humoral_immune3.36592363
6MP0005000_abnormal_immune_tolerance3.26208707
7MP0003724_increased_susceptibility_to3.26149571
8MP0001790_abnormal_immune_system3.07822010
9MP0005387_immune_system_phenotype3.07822010
10MP0009785_altered_susceptibility_to2.90403068
11MP0005025_abnormal_response_to2.87821530
12MP0002723_abnormal_immune_serum2.87113588
13MP0009333_abnormal_splenocyte_physiolog2.85693231
14MP0002420_abnormal_adaptive_immunity2.85218539
15MP0001819_abnormal_immune_cell2.80071220
16MP0000685_abnormal_immune_system2.72113840
17MP0003300_gastrointestinal_ulcer2.65739170
18MP0003866_abnormal_defecation2.62864401
19MP0002452_abnormal_antigen_presenting2.61785337
20MP0001873_stomach_inflammation2.61514569
21MP0002419_abnormal_innate_immunity2.61474618
22MP0002148_abnormal_hypersensitivity_rea2.51745191
23MP0002405_respiratory_system_inflammati2.47339390
24MP0002398_abnormal_bone_marrow2.47243991
25MP0000703_abnormal_thymus_morphology2.37320857
26MP0000716_abnormal_immune_system2.27542089
27MP0010155_abnormal_intestine_physiology2.27022485
28MP0003303_peritoneal_inflammation2.23749067
29MP0006082_CNS_inflammation2.22470276
30MP0000465_gastrointestinal_hemorrhage2.09935274
31MP0000689_abnormal_spleen_morphology2.03554106
32MP0002722_abnormal_immune_system2.02495568
33MP0005464_abnormal_platelet_physiology1.87466328
34MP0001845_abnormal_inflammatory_respons1.86200700
35MP0002166_altered_tumor_susceptibility1.82092753
36MP0004947_skin_inflammation1.80537372
37MP0002429_abnormal_blood_cell1.79571257
38MP0001853_heart_inflammation1.75743245
39MP0001533_abnormal_skeleton_physiology1.73991671
40MP0005310_abnormal_salivary_gland1.72305122
41MP0002277_abnormal_respiratory_mucosa1.69264587
42MP0004381_abnormal_hair_follicle1.54463200
43MP0002396_abnormal_hematopoietic_system1.47361131
44MP0008469_abnormal_protein_level1.36798890
45MP0001851_eye_inflammation1.33936568
46MP0009278_abnormal_bone_marrow1.29276764
47MP0005075_abnormal_melanosome_morpholog1.27242070
48MP0002006_tumorigenesis1.23609619
49MP0000490_abnormal_crypts_of1.22935940
50MP0002933_joint_inflammation1.20032039
51MP0002132_abnormal_respiratory_system1.14301555
52MP0008260_abnormal_autophagy1.13977308
53MP0001348_abnormal_lacrimal_gland1.12191080
54MP0000858_altered_metastatic_potential1.09866783
55MP0009764_decreased_sensitivity_to1.09548217
56MP0003191_abnormal_cellular_cholesterol1.03455461
57MP0002998_abnormal_bone_remodeling1.02234902
58MP0004510_myositis1.01308650
59MP0002138_abnormal_hepatobiliary_system0.94516678
60MP0009763_increased_sensitivity_to0.90017681
61MP0001663_abnormal_digestive_system0.86244177
62MP0000604_amyloidosis0.85904732
63MP0003448_altered_tumor_morphology0.85476489
64MP0001986_abnormal_taste_sensitivity0.83059760
65MP0005397_hematopoietic_system_phenotyp0.79420447
66MP0001545_abnormal_hematopoietic_system0.79420447
67MP0002693_abnormal_pancreas_physiology0.78418725
68MP0002163_abnormal_gland_morphology0.78068794
69MP0005166_decreased_susceptibility_to0.77940423
70MP0002019_abnormal_tumor_incidence0.76957313
71MP0005451_abnormal_body_composition0.76910678
72MP0003172_abnormal_lysosome_physiology0.74236504
73MP0003045_fibrosis0.69650679
74MP0002009_preneoplasia0.68696054
75MP0004883_abnormal_blood_vessel0.66822399
76MP0003828_pulmonary_edema0.64308441
77MP0005390_skeleton_phenotype0.63851537
78MP0004130_abnormal_muscle_cell0.63095541
79MP0004808_abnormal_hematopoietic_stem0.62609781
80MP0009765_abnormal_xenobiotic_induced0.61380004
81MP0009840_abnormal_foam_cell0.57478850
82MP0003795_abnormal_bone_structure0.55691546
83MP0000249_abnormal_blood_vessel0.53543269
84MP0003878_abnormal_ear_physiology0.50374779
85MP0005377_hearing/vestibular/ear_phenot0.50374779
86MP0001919_abnormal_reproductive_system0.48669337
87MP0008873_increased_physiological_sensi0.47284478
88MP0003075_altered_response_to0.46269189
89MP0001765_abnormal_ion_homeostasis0.42695594
90MP0005381_digestive/alimentary_phenotyp0.41898179
91MP0005164_abnormal_response_to0.41893811
92MP0008004_abnormal_stomach_pH0.39904698
93MP0008874_decreased_physiological_sensi0.39633543
94MP0008961_abnormal_basal_metabolism0.37104449
95MP0009642_abnormal_blood_homeostasis0.36343560
96MP0002136_abnormal_kidney_physiology0.35247024
97MP0003091_abnormal_cell_migration0.34318551
98MP0000343_altered_response_to0.34278649
99MP0000609_abnormal_liver_physiology0.34177277
100MP0004185_abnormal_adipocyte_glucose0.33668295

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)6.64695342
2Stomatitis (HP:0010280)6.59093591
3T lymphocytopenia (HP:0005403)5.79095133
4Eczematoid dermatitis (HP:0000976)5.78669672
5Abnormality of T cell number (HP:0011839)5.37704477
6Myositis (HP:0100614)5.13186715
7Recurrent abscess formation (HP:0002722)4.53990415
8Retrobulbar optic neuritis (HP:0100654)4.41555969
9Optic neuritis (HP:0100653)4.41555969
10Abnormality of T cells (HP:0002843)4.36470986
11Orchitis (HP:0100796)4.36212551
12Recurrent bacterial skin infections (HP:0005406)4.31587798
13Autoimmune hemolytic anemia (HP:0001890)4.23541839
14Recurrent fungal infections (HP:0002841)4.23022099
15Abnormal delayed hypersensitivity skin test (HP:0002963)4.18580375
16Severe combined immunodeficiency (HP:0004430)4.06937796
17Meningitis (HP:0001287)4.05289053
18Encephalitis (HP:0002383)4.02724060
19Increased IgM level (HP:0003496)4.01764927
20Abnormality of macrophages (HP:0004311)4.00892556
21IgG deficiency (HP:0004315)3.95574564
22Chronic obstructive pulmonary disease (HP:0006510)3.94852375
23Obstructive lung disease (HP:0006536)3.94852375
24Gastrointestinal infarctions (HP:0005244)3.93161727
25Vasculitis (HP:0002633)3.69634859
26Panhypogammaglobulinemia (HP:0003139)3.65860571
27Hypochromic microcytic anemia (HP:0004840)3.56930974
28Chronic mucocutaneous candidiasis (HP:0002728)3.53913018
29Recurrent cutaneous fungal infections (HP:0011370)3.53913018
30Pulmonary infiltrates (HP:0002113)3.49781381
31Chest pain (HP:0100749)3.46835831
32Mediastinal lymphadenopathy (HP:0100721)3.46599283
33Leukocytosis (HP:0001974)3.45392609
34Recurrent bronchitis (HP:0002837)3.39646435
35Lymphopenia (HP:0001888)3.38573382
36IgM deficiency (HP:0002850)3.34886992
37Abnormality of eosinophils (HP:0001879)3.33764126
38Spontaneous hematomas (HP:0007420)3.31586946
39Increased IgE level (HP:0003212)3.31433961
40Keratoconjunctivitis sicca (HP:0001097)3.30160341
41Granulocytopenia (HP:0001913)3.26145156
42Pustule (HP:0200039)3.25264389
43Combined immunodeficiency (HP:0005387)3.24189027
44Papilledema (HP:0001085)3.20486813
45Prolonged bleeding time (HP:0003010)3.20387741
46Hypochromic anemia (HP:0001931)3.17927432
47Recurrent skin infections (HP:0001581)3.15823390
48Abnormality of cells of the lymphoid lineage (HP:0012140)3.14824562
49Recurrent gram-negative bacterial infections (HP:0005420)3.11579663
50Eosinophilia (HP:0001880)3.10270510
51Recurrent viral infections (HP:0004429)3.10099196
52Keratoconjunctivitis (HP:0001096)3.08386074
53Hemoptysis (HP:0002105)3.04117049
54Abnormality of T cell physiology (HP:0011840)3.03174686
55Inflammation of the large intestine (HP:0002037)3.02331226
56Chronic diarrhea (HP:0002028)2.97062523
57Gastrointestinal inflammation (HP:0004386)2.93056905
58Epistaxis (HP:0000421)2.81164110
59Joint swelling (HP:0001386)2.79337321
60Agammaglobulinemia (HP:0004432)2.79304960
61Hypergammaglobulinemia (HP:0010702)2.77893566
62Urticaria (HP:0001025)2.74730567
63Pulmonary embolism (HP:0002204)2.74638694
64Petechiae (HP:0000967)2.74017724
65Acute hepatic failure (HP:0006554)2.63725703
66Gangrene (HP:0100758)2.58977837
67Microcytic anemia (HP:0001935)2.58095535
68Gingivitis (HP:0000230)2.53340217
69Chronic otitis media (HP:0000389)2.44259019
70Colitis (HP:0002583)2.43604278
71Abnormality of the pleura (HP:0002103)2.43395481
72Abnormality of B cell number (HP:0010975)2.42917750
73Abnormality of the prostate (HP:0008775)2.42236106
74Hypoplasia of the thymus (HP:0000778)2.41501290
75Papilloma (HP:0012740)2.39301575
76Verrucae (HP:0200043)2.39301575
77Gingival bleeding (HP:0000225)2.38116107
78B lymphocytopenia (HP:0010976)2.36412373
79Arterial thrombosis (HP:0004420)2.33841729
80Anorexia (HP:0002039)2.31586133
81Sepsis (HP:0100806)2.29523796
82Nasal polyposis (HP:0100582)2.28508520
83Glomerulopathy (HP:0100820)2.27409040
84Thyroiditis (HP:0100646)2.26627947
85Lymphoma (HP:0002665)2.22288008
86Episodic fever (HP:0001954)2.18526033
87Cellulitis (HP:0100658)2.10576714
88Purpura (HP:0000979)2.10208102
89Bronchitis (HP:0012387)2.06674983
90Recurrent sinusitis (HP:0011108)2.01549177
91Skin rash (HP:0000988)1.97501851
92Polyneuropathy (HP:0001271)1.95216566
93Keratitis (HP:0000491)1.90140331
94Osteomyelitis (HP:0002754)1.89238642
95Abnormality of the pericardium (HP:0001697)1.88833135
96Arthralgia (HP:0002829)1.88406966
97Increased serum ferritin (HP:0003281)1.87930578
98Skin ulcer (HP:0200042)1.87901475
99Restrictive lung disease (HP:0002091)1.87685165
100Gastrointestinal stroma tumor (HP:0100723)1.87608358

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.00563856
2TXK4.89085477
3RIPK43.48484604
4FES3.14949089
5TYK22.71262442
6CSK2.52224588
7ITK2.43494343
8ZAP702.31346996
9BTK2.26358275
10TNK22.22554039
11GRK62.17386355
12PASK2.12287929
13JAK32.04169070
14TEC1.94084852
15SIK31.89450974
16TESK21.89339696
17LCK1.83543325
18IKBKE1.83298657
19HCK1.82065843
20TAOK31.77658814
21SYK1.74238754
22JAK11.72956652
23PRPF4B1.67795331
24IRAK41.66190375
25BLK1.63001247
26EPHB11.57849677
27MARK31.57564824
28NLK1.46044494
29MAP2K31.42223462
30LYN1.40838890
31ERN11.40495572
32CAMKK21.39909077
33CAMKK11.37870633
34KDR1.33249464
35MAP3K111.27395621
36MST41.25588371
37TBK11.25032036
38TAOK11.20691699
39STK101.17569935
40MAP3K141.15745425
41IKBKB1.13435992
42JAK21.12867267
43MAP3K31.11005386
44FGFR41.09224121
45MAP3K131.08387662
46PIK3CG1.07696721
47PRKCQ1.01571620
48CSF1R0.97737037
49SIK20.95008541
50PDK10.85137381
51MAP3K10.81385735
52FGR0.80402725
53KIT0.80262163
54PIM10.76347969
55MAPK110.76034812
56HIPK20.74623846
57FYN0.74076961
58TAOK20.72409535
59FGFR30.71700232
60MAP3K100.71380874
61TYRO30.70501398
62CDK40.70172272
63GRK70.69517062
64LRRK20.66409125
65CDK190.65337769
66KSR20.58285622
67EPHA30.56997052
68CLK10.55714770
69MAP3K120.53210058
70PTK60.51544974
71MAPK120.50859563
72BMPR20.48058706
73MAP3K70.47343127
74SMG10.46923137
75TRIM280.44128875
76MARK20.43507688
77STK380.42509932
78MAP2K60.39442476
79PRKD20.38001613
80MAPKAPK20.37215888
81RPS6KL10.36817402
82RPS6KC10.36817402
83MAP3K50.35918682
84IRAK10.35116579
85MAP3K80.34904185
86PRKCH0.33423158
87CDK60.33316503
88PDPK10.32742408
89RPS6KA60.32366634
90DYRK1B0.32271674
91YES10.31253498
92STK110.30673667
93MELK0.30164907
94TGFBR20.28079252
95RAF10.27931399
96MAPK70.26897409
97CDK120.25168574
98PDGFRB0.24975914
99TRIB30.22795429
100SIK10.22216418

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.69948751
2T cell receptor signaling pathway_Homo sapiens_hsa046603.33836123
3Autoimmune thyroid disease_Homo sapiens_hsa053203.28261275
4Allograft rejection_Homo sapiens_hsa053303.22365268
5Graft-versus-host disease_Homo sapiens_hsa053323.13874266
6Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046503.09495618
7Measles_Homo sapiens_hsa051622.59513340
8Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.44758042
9Antigen processing and presentation_Homo sapiens_hsa046122.41785132
10Osteoclast differentiation_Homo sapiens_hsa043802.36587787
11Type I diabetes mellitus_Homo sapiens_hsa049402.34774201
12Hematopoietic cell lineage_Homo sapiens_hsa046402.31285672
13B cell receptor signaling pathway_Homo sapiens_hsa046622.01702009
14Leishmaniasis_Homo sapiens_hsa051401.91644379
15Jak-STAT signaling pathway_Homo sapiens_hsa046301.85189587
16NF-kappa B signaling pathway_Homo sapiens_hsa040641.84637286
17Viral myocarditis_Homo sapiens_hsa054161.84178100
18Acute myeloid leukemia_Homo sapiens_hsa052211.73903100
19Chemokine signaling pathway_Homo sapiens_hsa040621.72652852
20Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.67209809
21Intestinal immune network for IgA production_Homo sapiens_hsa046721.67148737
22Staphylococcus aureus infection_Homo sapiens_hsa051501.65157162
23Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.62369467
24RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.61847464
25NOD-like receptor signaling pathway_Homo sapiens_hsa046211.59533077
26Herpes simplex infection_Homo sapiens_hsa051681.58275951
27Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.54359102
28Malaria_Homo sapiens_hsa051441.50389562
29Toll-like receptor signaling pathway_Homo sapiens_hsa046201.49830458
30Asthma_Homo sapiens_hsa053101.38592996
31Tuberculosis_Homo sapiens_hsa051521.32847705
32Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.29984917
33Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.29791161
34Influenza A_Homo sapiens_hsa051641.26569267
35Toxoplasmosis_Homo sapiens_hsa051451.25647235
36TNF signaling pathway_Homo sapiens_hsa046681.18953032
37Non-small cell lung cancer_Homo sapiens_hsa052231.15670612
38Hepatitis B_Homo sapiens_hsa051611.12822255
39Leukocyte transendothelial migration_Homo sapiens_hsa046701.05012845
40Shigellosis_Homo sapiens_hsa051311.04610957
41Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.03943161
42Platelet activation_Homo sapiens_hsa046111.02401165
43Apoptosis_Homo sapiens_hsa042100.96647212
44Legionellosis_Homo sapiens_hsa051340.95754315
45Epstein-Barr virus infection_Homo sapiens_hsa051690.95306540
46Pancreatic cancer_Homo sapiens_hsa052120.93220686
47Rheumatoid arthritis_Homo sapiens_hsa053230.91001449
48HTLV-I infection_Homo sapiens_hsa051660.89007773
49Hepatitis C_Homo sapiens_hsa051600.87521340
50Viral carcinogenesis_Homo sapiens_hsa052030.86125381
51VEGF signaling pathway_Homo sapiens_hsa043700.86013468
52SNARE interactions in vesicular transport_Homo sapiens_hsa041300.85932155
53African trypanosomiasis_Homo sapiens_hsa051430.78519598
54Endocytosis_Homo sapiens_hsa041440.74928487
55Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.72706188
56Colorectal cancer_Homo sapiens_hsa052100.72376027
57Prolactin signaling pathway_Homo sapiens_hsa049170.72207629
58Phagosome_Homo sapiens_hsa041450.71959657
59Phosphatidylinositol signaling system_Homo sapiens_hsa040700.70637825
60Pertussis_Homo sapiens_hsa051330.70111785
61Chronic myeloid leukemia_Homo sapiens_hsa052200.65522983
62Salmonella infection_Homo sapiens_hsa051320.57953790
63FoxO signaling pathway_Homo sapiens_hsa040680.57076041
64Neurotrophin signaling pathway_Homo sapiens_hsa047220.56807094
65Renal cell carcinoma_Homo sapiens_hsa052110.56563946
66AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.53300969
67Endometrial cancer_Homo sapiens_hsa052130.52595294
68Proteasome_Homo sapiens_hsa030500.51175406
69Sphingolipid signaling pathway_Homo sapiens_hsa040710.49571209
70Carbohydrate digestion and absorption_Homo sapiens_hsa049730.47430096
71Regulation of autophagy_Homo sapiens_hsa041400.46553320
72Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.46014217
73Choline metabolism in cancer_Homo sapiens_hsa052310.44473607
74Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.44164431
75Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.42549989
76MAPK signaling pathway_Homo sapiens_hsa040100.41582777
77Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.41469508
78Transcriptional misregulation in cancer_Homo sapiens_hsa052020.41086863
79Other glycan degradation_Homo sapiens_hsa005110.40348003
80Inositol phosphate metabolism_Homo sapiens_hsa005620.39592246
81Adipocytokine signaling pathway_Homo sapiens_hsa049200.39237753
82Phospholipase D signaling pathway_Homo sapiens_hsa040720.37643807
83Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.36698376
84mTOR signaling pathway_Homo sapiens_hsa041500.35481148
85Insulin resistance_Homo sapiens_hsa049310.34325578
86Long-term potentiation_Homo sapiens_hsa047200.33296620
87HIF-1 signaling pathway_Homo sapiens_hsa040660.30859158
88Ras signaling pathway_Homo sapiens_hsa040140.28005315
89Prostate cancer_Homo sapiens_hsa052150.27575531
90Notch signaling pathway_Homo sapiens_hsa043300.26862266
91Glycerophospholipid metabolism_Homo sapiens_hsa005640.25890589
92Thyroid cancer_Homo sapiens_hsa052160.25213477
93Collecting duct acid secretion_Homo sapiens_hsa049660.21421257
94Rap1 signaling pathway_Homo sapiens_hsa040150.20897015
95Type II diabetes mellitus_Homo sapiens_hsa049300.20254043
96Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.19347161
97Regulation of actin cytoskeleton_Homo sapiens_hsa048100.18616668
98Dorso-ventral axis formation_Homo sapiens_hsa043200.17776614
99Ribosome_Homo sapiens_hsa030100.16125985
100ErbB signaling pathway_Homo sapiens_hsa040120.15271675

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