TRBV4-2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1tolerance induction (GO:0002507)6.92908290
2positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)6.85168572
3negative T cell selection (GO:0043383)6.31183421
4positive regulation of gamma-delta T cell activation (GO:0046645)6.26677485
5negative thymic T cell selection (GO:0045060)6.09928131
6regulation of B cell receptor signaling pathway (GO:0050855)5.94059824
7cellular response to interleukin-15 (GO:0071350)5.91220958
8antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.82328756
9regulation of regulatory T cell differentiation (GO:0045589)5.74498863
10response to interleukin-15 (GO:0070672)5.73626775
11antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.68899860
12negative regulation of cell killing (GO:0031342)5.66324168
13negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.66324168
14regulation of T cell tolerance induction (GO:0002664)5.54801614
15regulation of isotype switching to IgG isotypes (GO:0048302)5.39702452
16T cell migration (GO:0072678)5.35779615
17antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.27572190
18positive regulation of interleukin-2 biosynthetic process (GO:0045086)5.25479399
19thymic T cell selection (GO:0045061)5.21541660
20positive regulation of tolerance induction (GO:0002645)5.17953041
21regulation of gamma-delta T cell differentiation (GO:0045586)5.08691498
22antigen processing and presentation of endogenous antigen (GO:0019883)5.05752494
23T cell selection (GO:0045058)4.92299618
24positive T cell selection (GO:0043368)4.86678691
25regulation of interleukin-2 biosynthetic process (GO:0045076)4.76789927
26positive thymic T cell selection (GO:0045059)4.74139422
27regulation of gamma-delta T cell activation (GO:0046643)4.66134139
28regulation of tolerance induction (GO:0002643)4.61534391
29activated T cell proliferation (GO:0050798)4.51971386
30T cell receptor signaling pathway (GO:0050852)4.48289010
31regulation of antigen receptor-mediated signaling pathway (GO:0050854)4.46549124
32regulation of alpha-beta T cell proliferation (GO:0046640)4.36662090
33negative regulation of T cell mediated immunity (GO:0002710)4.33309547
34regulation of natural killer cell mediated immunity (GO:0002715)4.29691998
35regulation of natural killer cell mediated cytotoxicity (GO:0042269)4.29691998
36regulation of T cell receptor signaling pathway (GO:0050856)4.22120561
37antigen receptor-mediated signaling pathway (GO:0050851)4.19030088
38leukocyte aggregation (GO:0070486)4.14518001
39positive regulation of natural killer cell mediated immunity (GO:0002717)4.10605920
40interferon-gamma production (GO:0032609)3.98003470
41cytidine deamination (GO:0009972)3.97351478
42cytidine metabolic process (GO:0046087)3.97351478
43cytidine catabolic process (GO:0006216)3.97351478
44positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.90694885
45positive regulation of alpha-beta T cell proliferation (GO:0046641)3.88368417
46T cell costimulation (GO:0031295)3.87027398
47lymphocyte costimulation (GO:0031294)3.82391139
48positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.79415157
49negative regulation of lymphocyte mediated immunity (GO:0002707)3.77723038
50regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.76549162
51regulation of lymphocyte chemotaxis (GO:1901623)3.75774656
52regulation of B cell differentiation (GO:0045577)3.74881981
53regulation of leukocyte mediated cytotoxicity (GO:0001910)3.74488405
54pyrimidine ribonucleoside catabolic process (GO:0046133)3.72423937
55regulation of T cell mediated cytotoxicity (GO:0001914)3.70938770
56positive regulation of T cell mediated cytotoxicity (GO:0001916)3.69494338
57T cell homeostasis (GO:0043029)3.68143211
58alpha-beta T cell differentiation (GO:0046632)3.66531868
59chemokine-mediated signaling pathway (GO:0070098)3.63064744
60lymphocyte chemotaxis (GO:0048247)3.60993675
61lymphocyte migration (GO:0072676)3.59896404
62positive regulation of cell killing (GO:0031343)3.57775433
63negative regulation of leukocyte mediated immunity (GO:0002704)3.57039317
64positive regulation of interleukin-2 production (GO:0032743)3.56923581
65positive regulation of calcium-mediated signaling (GO:0050850)3.55612485
66positive regulation of granulocyte differentiation (GO:0030854)3.54419332
67mast cell activation (GO:0045576)3.49439872
68regulation of interleukin-12 biosynthetic process (GO:0045075)3.46465759
69Arp2/3 complex-mediated actin nucleation (GO:0034314)3.46255867
70positive regulation of lymphocyte migration (GO:2000403)3.45763172
71regulation of cell killing (GO:0031341)3.45543447
72antigen processing and presentation via MHC class Ib (GO:0002475)3.44272616
73negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.42083606
74DNA deamination (GO:0045006)3.42050791
75positive regulation of interleukin-4 production (GO:0032753)3.41685381
76regulation of chronic inflammatory response (GO:0002676)3.41431200
77type I interferon signaling pathway (GO:0060337)3.38349513
78cellular response to type I interferon (GO:0071357)3.38349513
79positive regulation of T cell differentiation in thymus (GO:0033089)3.36552581
80regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.34386372
81response to type I interferon (GO:0034340)3.34298547
82alpha-beta T cell activation (GO:0046631)3.32608184
83NIK/NF-kappaB signaling (GO:0038061)3.31166796
84myeloid dendritic cell differentiation (GO:0043011)3.30598285
85T cell differentiation (GO:0030217)3.29345784
86positive regulation of humoral immune response (GO:0002922)3.27501838
87B cell receptor signaling pathway (GO:0050853)3.23720453
88myeloid dendritic cell activation (GO:0001773)3.23691956
89negative regulation of T cell receptor signaling pathway (GO:0050860)3.23383126
90dendritic cell chemotaxis (GO:0002407)3.19320422
91positive regulation of B cell differentiation (GO:0045579)3.17935288
92regulation of interleukin-2 production (GO:0032663)3.15761502
93CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.14378983
94regulation of defense response to virus by virus (GO:0050690)3.13510246
95CD4-positive, alpha-beta T cell differentiation (GO:0043367)3.11923777
96positive regulation of T cell mediated immunity (GO:0002711)3.11323472
97regulation of lymphocyte migration (GO:2000401)3.10464826
98positive regulation of lymphocyte mediated immunity (GO:0002708)3.10213204
99detection of bacterium (GO:0016045)3.08559291
100positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.06763417

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_20620947_ChIP-Seq_CD4_POS_T_Human6.69983859
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse6.68753802
3BP1_19119308_ChIP-ChIP_Hs578T_Human6.49136616
4IRF8_22096565_ChIP-ChIP_GC-B_Human4.75145566
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.04858239
6RUNX_20019798_ChIP-Seq_JUKART_Human3.92360730
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.69541047
8MYB_26560356_Chip-Seq_TH2_Human3.60742142
9STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.43062728
10IRF8_21731497_ChIP-ChIP_J774_Mouse3.33911393
11STAT4_19710469_ChIP-ChIP_TH1__Mouse3.22179797
12MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.06671738
13SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.03771249
14SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.85169724
15FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.82345087
16MAF_26560356_Chip-Seq_TH1_Human2.74277719
17MYB_26560356_Chip-Seq_TH1_Human2.71512754
18ELF1_17652178_ChIP-ChIP_JURKAT_Human2.70570943
19UTX_26944678_Chip-Seq_JUKART_Human2.43456772
20RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.42000853
21GATA3_27048872_Chip-Seq_THYMUS_Human2.36100860
22MAF_26560356_Chip-Seq_TH2_Human2.28431081
23SPI1_23547873_ChIP-Seq_NB4_Human2.18792182
24SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.15700749
25IRF8_27001747_Chip-Seq_BMDM_Mouse2.14260337
26MYC_22102868_ChIP-Seq_BL_Human2.03904038
27NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.90716328
28SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.88980520
29NOTCH1_21737748_ChIP-Seq_TLL_Human1.88162454
30FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.86065865
31GATA3_26560356_Chip-Seq_TH2_Human1.85991764
32E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.80911415
33MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.70669279
34SMAD_19615063_ChIP-ChIP_OVARY_Human1.70456495
35RUNX1_22412390_ChIP-Seq_EML_Mouse1.69849777
36MYB_21317192_ChIP-Seq_ERMYB_Mouse1.68750057
37E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.60546550
38RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.52731848
39CIITA_25753668_ChIP-Seq_RAJI_Human1.49176275
40VDR_21846776_ChIP-Seq_THP-1_Human1.48924877
41SCL_19346495_ChIP-Seq_HPC-7_Human1.48131891
42BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.48049124
43SPI1_23127762_ChIP-Seq_K562_Human1.47514607
44VDR_24763502_ChIP-Seq_THP-1_Human1.45489521
45VDR_23849224_ChIP-Seq_CD4+_Human1.44751719
46BRD4_27068464_Chip-Seq_AML-cells_Mouse1.43465274
47ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.42181704
48RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.41943605
49LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.38441463
50NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.38313347
51KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.35503856
52FOXP3_21729870_ChIP-Seq_TREG_Human1.31334108
53SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.30099827
54TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.29359776
55NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.26999122
56LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.19613088
57TCF7_22412390_ChIP-Seq_EML_Mouse1.18421841
58KDM2B_26808549_Chip-Seq_DND41_Human1.16719379
59GATA2_22383799_ChIP-Seq_G1ME_Mouse1.13339833
60GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.10804705
61CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.10586163
62VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.07929226
63NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.07247954
64CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05579944
65CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05405630
66CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05067777
67KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.02954660
68HOXB4_20404135_ChIP-ChIP_EML_Mouse0.97739445
69PU_27001747_Chip-Seq_BMDM_Mouse0.97609092
70FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95225115
71PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94772823
72VDR_24787735_ChIP-Seq_THP-1_Human0.93866687
73PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93615274
74PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93615258
75KDM2B_26808549_Chip-Seq_SUP-B15_Human0.90558693
76PU.1_20513432_ChIP-Seq_Bcells_Mouse0.90441764
77STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.87769936
78GATA1_22025678_ChIP-Seq_K562_Human0.87240617
79BCL6_27268052_Chip-Seq_Bcells_Human0.86241343
80KDM2B_26808549_Chip-Seq_JURKAT_Human0.84459311
81PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.83882846
82GATA3_26560356_Chip-Seq_TH1_Human0.83437486
83TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.83068557
84RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.81001083
85CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.80159667
86TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.79982371
87Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.79801743
88GABP_17652178_ChIP-ChIP_JURKAT_Human0.78328590
89GATA1_19941827_ChIP-Seq_MEL_Mouse0.78241550
90GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.77620127
91SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.77390959
92EST1_17652178_ChIP-ChIP_JURKAT_Human0.74992674
93EGR1_19374776_ChIP-ChIP_THP-1_Human0.74039985
94GATA1_22383799_ChIP-Seq_G1ME_Mouse0.72761986
95ELF1_20517297_ChIP-Seq_JURKAT_Human0.71328339
96RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.71089193
97CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.69234771
98TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.68669672
99SMRT_27268052_Chip-Seq_Bcells_Human0.66664322
100ERG_20887958_ChIP-Seq_HPC-7_Mouse0.66052293

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology5.16136774
2MP0005671_abnormal_response_to5.07273812
3MP0001835_abnormal_antigen_presentation3.74544427
4MP0003436_decreased_susceptibility_to3.52490159
5MP0001800_abnormal_humoral_immune3.48206903
6MP0009333_abnormal_splenocyte_physiolog3.44678796
7MP0005000_abnormal_immune_tolerance3.29201499
8MP0001873_stomach_inflammation3.20717111
9MP0001790_abnormal_immune_system3.19976147
10MP0005387_immune_system_phenotype3.19976147
11MP0009785_altered_susceptibility_to3.16087106
12MP0002723_abnormal_immune_serum2.92818966
13MP0002420_abnormal_adaptive_immunity2.85742423
14MP0001819_abnormal_immune_cell2.80352731
15MP0005025_abnormal_response_to2.76971658
16MP0002148_abnormal_hypersensitivity_rea2.76363986
17MP0006082_CNS_inflammation2.70553278
18MP0003866_abnormal_defecation2.69553713
19MP0002452_abnormal_antigen_presenting2.62178960
20MP0000703_abnormal_thymus_morphology2.55119375
21MP0000685_abnormal_immune_system2.54293657
22MP0002405_respiratory_system_inflammati2.50341277
23MP0002398_abnormal_bone_marrow2.45421059
24MP0003724_increased_susceptibility_to2.31640546
25MP0000716_abnormal_immune_system2.26439330
26MP0002419_abnormal_innate_immunity2.22885307
27MP0010155_abnormal_intestine_physiology2.22519044
28MP0000689_abnormal_spleen_morphology2.02515067
29MP0002722_abnormal_immune_system2.00337230
30MP0002166_altered_tumor_susceptibility1.94421711
31MP0003300_gastrointestinal_ulcer1.92298800
32MP0002277_abnormal_respiratory_mucosa1.91413285
33MP0004947_skin_inflammation1.84984679
34MP0001845_abnormal_inflammatory_respons1.83699780
35MP0002429_abnormal_blood_cell1.75819937
36MP0000465_gastrointestinal_hemorrhage1.75297402
37MP0004381_abnormal_hair_follicle1.72478150
38MP0005310_abnormal_salivary_gland1.70016927
39MP0003303_peritoneal_inflammation1.61379326
40MP0005464_abnormal_platelet_physiology1.56844733
41MP0001533_abnormal_skeleton_physiology1.46217110
42MP0001851_eye_inflammation1.44258061
43MP0005075_abnormal_melanosome_morpholog1.41887205
44MP0002006_tumorigenesis1.37345501
45MP0008469_abnormal_protein_level1.34106061
46MP0002933_joint_inflammation1.28994620
47MP0001348_abnormal_lacrimal_gland1.23732691
48MP0003045_fibrosis1.23367803
49MP0001853_heart_inflammation1.21410120
50MP0002163_abnormal_gland_morphology1.13869870
51MP0002138_abnormal_hepatobiliary_system1.08021040
52MP0009764_decreased_sensitivity_to1.01808801
53MP0000490_abnormal_crypts_of1.00427713
54MP0000858_altered_metastatic_potential1.00343472
55MP0003172_abnormal_lysosome_physiology1.00309368
56MP0002396_abnormal_hematopoietic_system0.99223070
57MP0008260_abnormal_autophagy0.98328384
58MP0000604_amyloidosis0.96117515
59MP0003448_altered_tumor_morphology0.96033288
60MP0002132_abnormal_respiratory_system0.95723898
61MP0002998_abnormal_bone_remodeling0.92921590
62MP0009763_increased_sensitivity_to0.92724763
63MP0002693_abnormal_pancreas_physiology0.91689361
64MP0001663_abnormal_digestive_system0.88568888
65MP0005166_decreased_susceptibility_to0.84967812
66MP0000569_abnormal_digit_pigmentation0.83554526
67MP0003183_abnormal_peptide_metabolism0.81645462
68MP0002019_abnormal_tumor_incidence0.75633924
69MP0002009_preneoplasia0.71740614
70MP0004510_myositis0.67102617
71MP0009765_abnormal_xenobiotic_induced0.63264751
72MP0001919_abnormal_reproductive_system0.63089906
73MP0000015_abnormal_ear_pigmentation0.62822533
74MP0005058_abnormal_lysosome_morphology0.59601000
75MP0003795_abnormal_bone_structure0.56040326
76MP0004883_abnormal_blood_vessel0.55598313
77MP0003806_abnormal_nucleotide_metabolis0.54813176
78MP0005390_skeleton_phenotype0.53454371
79MP0004742_abnormal_vestibular_system0.51402320
80MP0003786_premature_aging0.46034359
81MP0003828_pulmonary_edema0.45633880
82MP0008873_increased_physiological_sensi0.44087099
83MP0001765_abnormal_ion_homeostasis0.43363908
84MP0005381_digestive/alimentary_phenotyp0.43110834
85MP0002254_reproductive_system_inflammat0.42096253
86MP0002136_abnormal_kidney_physiology0.42088591
87MP0006054_spinal_hemorrhage0.41651184
88MP0008569_lethality_at_weaning0.41530118
89MP0000477_abnormal_intestine_morphology0.39488107
90MP0005379_endocrine/exocrine_gland_phen0.39037396
91MP0000249_abnormal_blood_vessel0.38960770
92MP0004808_abnormal_hematopoietic_stem0.38758555
93MP0002083_premature_death0.38272095
94MP0000920_abnormal_myelination0.37775917
95MP0000371_diluted_coat_color0.37075509
96MP0003329_amyloid_beta_deposits0.36622950
97MP0000609_abnormal_liver_physiology0.35602054
98MP0001501_abnormal_sleep_pattern0.34988074
99MP0005451_abnormal_body_composition0.34698135
100MP0003075_altered_response_to0.34107968

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)7.02958411
2T lymphocytopenia (HP:0005403)6.61748429
3Abnormality of T cell number (HP:0011839)6.19455565
4Elevated erythrocyte sedimentation rate (HP:0003565)5.99698102
5Autoimmune hemolytic anemia (HP:0001890)5.55964387
6IgG deficiency (HP:0004315)5.18705847
7Abnormality of T cells (HP:0002843)4.96307534
8Eczematoid dermatitis (HP:0000976)4.65664795
9Severe combined immunodeficiency (HP:0004430)4.62567092
10Increased IgM level (HP:0003496)4.55812610
11Gastrointestinal infarctions (HP:0005244)4.39010393
12IgM deficiency (HP:0002850)4.37504345
13Abnormal delayed hypersensitivity skin test (HP:0002963)4.37202708
14Recurrent bronchitis (HP:0002837)4.26129255
15Recurrent fungal infections (HP:0002841)4.21956063
16Recurrent bacterial skin infections (HP:0005406)4.09871543
17Myositis (HP:0100614)4.01787132
18Chronic diarrhea (HP:0002028)3.95932775
19Meningitis (HP:0001287)3.91201761
20Abnormality of eosinophils (HP:0001879)3.87454674
21Encephalitis (HP:0002383)3.86337888
22Recurrent abscess formation (HP:0002722)3.85703907
23Recurrent cutaneous fungal infections (HP:0011370)3.80451046
24Chronic mucocutaneous candidiasis (HP:0002728)3.80451046
25Obstructive lung disease (HP:0006536)3.72570665
26Chronic obstructive pulmonary disease (HP:0006510)3.72570665
27Mediastinal lymphadenopathy (HP:0100721)3.70492974
28Vasculitis (HP:0002633)3.68512550
29Abnormality of macrophages (HP:0004311)3.66076668
30Combined immunodeficiency (HP:0005387)3.63550103
31Pulmonary infiltrates (HP:0002113)3.61035030
32Abnormality of T cell physiology (HP:0011840)3.55486987
33B lymphocytopenia (HP:0010976)3.54888893
34Lymphopenia (HP:0001888)3.53620295
35Pustule (HP:0200039)3.51759709
36Leukocytosis (HP:0001974)3.50444825
37Eosinophilia (HP:0001880)3.44885251
38Retrobulbar optic neuritis (HP:0100654)3.43475815
39Optic neuritis (HP:0100653)3.43475815
40Abnormality of B cell number (HP:0010975)3.41150002
41Granulocytopenia (HP:0001913)3.35973612
42Abnormality of cells of the lymphoid lineage (HP:0012140)3.34004949
43Recurrent viral infections (HP:0004429)3.32051453
44Orchitis (HP:0100796)3.29953639
45Recurrent skin infections (HP:0001581)3.24765999
46Joint swelling (HP:0001386)3.22544592
47Chest pain (HP:0100749)3.22333847
48Panhypogammaglobulinemia (HP:0003139)3.12119160
49Abnormality of the prostate (HP:0008775)2.99835566
50Thyroiditis (HP:0100646)2.97908390
51Acute hepatic failure (HP:0006554)2.92083912
52Hemoptysis (HP:0002105)2.88855062
53Increased IgE level (HP:0003212)2.82526422
54Agammaglobulinemia (HP:0004432)2.79641249
55Hypoplasia of the thymus (HP:0000778)2.78365844
56Hypochromic microcytic anemia (HP:0004840)2.73511519
57Aplastic anemia (HP:0001915)2.71582181
58Lymphoma (HP:0002665)2.67604795
59Hypochromic anemia (HP:0001931)2.65946379
60Hypergammaglobulinemia (HP:0010702)2.65692583
61Gangrene (HP:0100758)2.62692906
62Keratoconjunctivitis sicca (HP:0001097)2.59342917
63Spontaneous hematomas (HP:0007420)2.56701034
64Bronchitis (HP:0012387)2.51374745
65Pulmonary embolism (HP:0002204)2.50884967
66Keratoconjunctivitis (HP:0001096)2.43955344
67Papilledema (HP:0001085)2.40307592
68Abnormality of the pleura (HP:0002103)2.36896231
69Recurrent gram-negative bacterial infections (HP:0005420)2.35719292
70Gingivitis (HP:0000230)2.33482275
71Epistaxis (HP:0000421)2.21294379
72Anorexia (HP:0002039)2.18332986
73Diplopia (HP:0000651)2.17385212
74Abnormality of binocular vision (HP:0011514)2.17385212
75Recurrent sinusitis (HP:0011108)2.16817479
76Verrucae (HP:0200043)2.16664718
77Papilloma (HP:0012740)2.16664718
78Hypoproteinemia (HP:0003075)2.16028619
79IgA deficiency (HP:0002720)2.14190243
80Glomerulopathy (HP:0100820)2.13612537
81Inflammation of the large intestine (HP:0002037)2.12235620
82Urticaria (HP:0001025)2.12188073
83Petechiae (HP:0000967)2.11667214
84Pancytopenia (HP:0001876)2.11214849
85Arterial thrombosis (HP:0004420)2.10191934
86Ureteral stenosis (HP:0000071)2.08329970
87Microcytic anemia (HP:0001935)2.04570413
88Gastrointestinal inflammation (HP:0004386)2.03867513
89Skin rash (HP:0000988)2.03637424
90Alveolar cell carcinoma (HP:0006519)2.02803032
91Premature loss of primary teeth (HP:0006323)2.01691882
92Chronic otitis media (HP:0000389)2.00108106
93Nasal polyposis (HP:0100582)2.00004482
94Ureteral obstruction (HP:0006000)1.98489234
95Stomach cancer (HP:0012126)1.97403155
96Autoimmune thrombocytopenia (HP:0001973)1.97044221
97Gastrointestinal stroma tumor (HP:0100723)1.96339102
98Prolonged bleeding time (HP:0003010)1.95002676
99Sepsis (HP:0100806)1.93178247
100Neutropenia (HP:0001875)1.90584587

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK7.20972247
2MAP4K16.10093189
3ITK3.36813404
4FES3.01703932
5ZAP702.45091561
6CSK2.32576833
7TYK22.31103263
8BTK2.22293167
9JAK32.13372420
10RIPK42.08125665
11TEC2.05631259
12LCK2.04076762
13GRK61.89870924
14IKBKE1.82271527
15PASK1.78012727
16SYK1.76300964
17TESK21.73236169
18JAK11.67739720
19KDR1.62843883
20HCK1.62843681
21TNK21.58034791
22SIK31.55997255
23MAP3K111.46431527
24SCYL21.45931822
25BLK1.40381734
26TAOK31.37237530
27MAP3K121.36966786
28MARK31.35823735
29LYN1.35569125
30IRAK41.35469138
31MAP3K141.34229425
32PRKCQ1.33704541
33TBK11.29485389
34PRPF4B1.29147310
35IKBKB1.26626792
36CAMKK21.25587753
37FGFR41.25154137
38NLK1.20416656
39MST41.16163441
40CAMKK11.13748375
41TYRO31.11608380
42MAP2K31.02731772
43EPHB10.98403270
44JAK20.95318031
45STK100.92394951
46TAOK10.86247437
47CSF1R0.84551688
48MAP3K30.83190107
49FGFR30.81470474
50FYN0.80363857
51TAOK20.77240542
52SIK20.74169396
53PRKCH0.73758410
54MAP3K10.70436826
55MAPK110.65744208
56PIM10.64509859
57PDK10.61737894
58MAP3K130.60883609
59CLK10.60808870
60HIPK20.60235926
61KIT0.58502046
62EPHA30.54093317
63GRK70.52772843
64CDK40.51839121
65MAPK120.50522932
66MAPKAPK30.49033630
67MAP3K100.48985591
68ACVR1B0.47519523
69PRKD20.47334393
70MAPKAPK20.43667415
71PIK3CG0.43379585
72CHUK0.42525772
73LRRK20.40836980
74IRAK10.36410299
75MAP2K60.35429668
76IGF1R0.33663703
77PDGFRB0.33338545
78INSR0.33189946
79ERN10.32032543
80FGR0.30584616
81CDK190.29600763
82TGFBR20.27386716
83RPS6KA40.25865552
84EIF2AK30.25752243
85SMG10.25723153
86BUB10.25642530
87RPS6KA50.24759707
88MAP3K50.22566362
89MAP3K70.22132004
90MAPK70.21482094
91PRKCD0.21461442
92EGFR0.18452696
93MAPK30.17957218
94NTRK20.16746566
95NEK60.16450497
96MELK0.15662738
97MARK20.14107665
98FGFR10.13520214
99TESK10.13100527
100ABL10.12853986

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.61293982
2T cell receptor signaling pathway_Homo sapiens_hsa046603.91696607
3Autoimmune thyroid disease_Homo sapiens_hsa053203.26298036
4Graft-versus-host disease_Homo sapiens_hsa053323.24881969
5Allograft rejection_Homo sapiens_hsa053303.20455719
6Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046503.18476691
7Measles_Homo sapiens_hsa051622.76564797
8Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.74895789
9Antigen processing and presentation_Homo sapiens_hsa046122.65039818
10NF-kappa B signaling pathway_Homo sapiens_hsa040642.54000461
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.49027539
12Hematopoietic cell lineage_Homo sapiens_hsa046402.40754155
13Type I diabetes mellitus_Homo sapiens_hsa049402.33959547
14Osteoclast differentiation_Homo sapiens_hsa043802.16298182
15Toll-like receptor signaling pathway_Homo sapiens_hsa046201.96487613
16Chemokine signaling pathway_Homo sapiens_hsa040621.83886400
17Viral myocarditis_Homo sapiens_hsa054161.79721288
18RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.74479731
19Intestinal immune network for IgA production_Homo sapiens_hsa046721.69193056
20B cell receptor signaling pathway_Homo sapiens_hsa046621.67972196
21Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.66615649
22Leishmaniasis_Homo sapiens_hsa051401.60538937
23Jak-STAT signaling pathway_Homo sapiens_hsa046301.60507172
24Herpes simplex infection_Homo sapiens_hsa051681.56820102
25NOD-like receptor signaling pathway_Homo sapiens_hsa046211.44200767
26Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.43882626
27Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.32901847
28Salmonella infection_Homo sapiens_hsa051321.31401715
29Rheumatoid arthritis_Homo sapiens_hsa053231.31324419
30Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.31239385
31TNF signaling pathway_Homo sapiens_hsa046681.30964929
32Staphylococcus aureus infection_Homo sapiens_hsa051501.27636986
33Shigellosis_Homo sapiens_hsa051311.21516483
34Asthma_Homo sapiens_hsa053101.20593942
35Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.19772922
36Acute myeloid leukemia_Homo sapiens_hsa052211.17804736
37Epstein-Barr virus infection_Homo sapiens_hsa051691.10878488
38Influenza A_Homo sapiens_hsa051641.08469233
39Hepatitis B_Homo sapiens_hsa051611.08064671
40Malaria_Homo sapiens_hsa051441.07472223
41Tuberculosis_Homo sapiens_hsa051521.07247034
42SNARE interactions in vesicular transport_Homo sapiens_hsa041301.04135771
43Toxoplasmosis_Homo sapiens_hsa051450.97507247
44Proteasome_Homo sapiens_hsa030500.96982898
45Apoptosis_Homo sapiens_hsa042100.94878483
46Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.93179352
47Legionellosis_Homo sapiens_hsa051340.93145834
48HTLV-I infection_Homo sapiens_hsa051660.90468200
49Non-small cell lung cancer_Homo sapiens_hsa052230.86189104
50Leukocyte transendothelial migration_Homo sapiens_hsa046700.84517725
51Viral carcinogenesis_Homo sapiens_hsa052030.82236894
52Platelet activation_Homo sapiens_hsa046110.77361023
53Hepatitis C_Homo sapiens_hsa051600.75925738
54African trypanosomiasis_Homo sapiens_hsa051430.73272062
55Endocytosis_Homo sapiens_hsa041440.71205840
56Pancreatic cancer_Homo sapiens_hsa052120.68167143
57VEGF signaling pathway_Homo sapiens_hsa043700.66757682
58Pertussis_Homo sapiens_hsa051330.65937438
59Prolactin signaling pathway_Homo sapiens_hsa049170.53327310
60Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.52575555
61Regulation of autophagy_Homo sapiens_hsa041400.52549061
62Colorectal cancer_Homo sapiens_hsa052100.49811020
63Protein export_Homo sapiens_hsa030600.47732074
64RNA polymerase_Homo sapiens_hsa030200.47380821
65Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.46979076
66Chronic myeloid leukemia_Homo sapiens_hsa052200.46811772
67Phagosome_Homo sapiens_hsa041450.45715785
68Prion diseases_Homo sapiens_hsa050200.43230705
69Sphingolipid signaling pathway_Homo sapiens_hsa040710.41882799
70MAPK signaling pathway_Homo sapiens_hsa040100.39279876
71AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.38510591
72Phosphatidylinositol signaling system_Homo sapiens_hsa040700.37752387
73Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.36718182
74Neurotrophin signaling pathway_Homo sapiens_hsa047220.34413058
75Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.33512626
76FoxO signaling pathway_Homo sapiens_hsa040680.32454153
77Inositol phosphate metabolism_Homo sapiens_hsa005620.28708988
78Adipocytokine signaling pathway_Homo sapiens_hsa049200.28298594
79Transcriptional misregulation in cancer_Homo sapiens_hsa052020.25421702
80Renal cell carcinoma_Homo sapiens_hsa052110.22664784
81Carbohydrate digestion and absorption_Homo sapiens_hsa049730.22469565
82Insulin resistance_Homo sapiens_hsa049310.19907908
83Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.17668448
84Long-term potentiation_Homo sapiens_hsa047200.16885717
85Endometrial cancer_Homo sapiens_hsa052130.16088904
86Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.15206216
87HIF-1 signaling pathway_Homo sapiens_hsa040660.14264417
88Spliceosome_Homo sapiens_hsa030400.12955423
89Notch signaling pathway_Homo sapiens_hsa043300.12235810
90Ras signaling pathway_Homo sapiens_hsa040140.11982018
91Regulation of actin cytoskeleton_Homo sapiens_hsa048100.11559013
92Rap1 signaling pathway_Homo sapiens_hsa040150.10136484
93Lysosome_Homo sapiens_hsa041420.09241150
94Prostate cancer_Homo sapiens_hsa052150.07852522
95Collecting duct acid secretion_Homo sapiens_hsa049660.05669013
96Glycerophospholipid metabolism_Homo sapiens_hsa005640.03664781
97Choline metabolism in cancer_Homo sapiens_hsa052310.02327883
98Phospholipase D signaling pathway_Homo sapiens_hsa040720.02249866
99RNA degradation_Homo sapiens_hsa030180.01650546
100Circadian rhythm_Homo sapiens_hsa047100.00863560

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