TRBV5-1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative T cell selection (GO:0043383)7.47700044
2positive regulation of gamma-delta T cell activation (GO:0046645)7.15182472
3cellular response to interleukin-15 (GO:0071350)6.86404504
4negative thymic T cell selection (GO:0045060)6.55210402
5negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.51719168
6negative regulation of cell killing (GO:0031342)6.51719168
7positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)6.51573501
8antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.41185960
9response to interleukin-15 (GO:0070672)6.30580783
10regulation of B cell receptor signaling pathway (GO:0050855)6.08954380
11positive T cell selection (GO:0043368)6.08917340
12positive regulation of granulocyte differentiation (GO:0030854)5.64599855
13regulation of gamma-delta T cell differentiation (GO:0045586)5.62965525
14T cell selection (GO:0045058)5.61935673
15antigen processing and presentation of endogenous antigen (GO:0019883)5.59523084
16antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.50710517
17activated T cell proliferation (GO:0050798)5.28806735
18positive thymic T cell selection (GO:0045059)5.27612917
19thymic T cell selection (GO:0045061)5.17981909
20tolerance induction (GO:0002507)5.17154659
21regulation of gamma-delta T cell activation (GO:0046643)5.16157952
22antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.11184700
23regulation of regulatory T cell differentiation (GO:0045589)4.95425504
24leukocyte aggregation (GO:0070486)4.93555114
25T cell migration (GO:0072678)4.80864564
26positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.71913858
27negative regulation of T cell mediated immunity (GO:0002710)4.69721395
28regulation of T cell tolerance induction (GO:0002664)4.67256350
29antigen processing and presentation via MHC class Ib (GO:0002475)4.45378269
30negative regulation of phagocytosis (GO:0050765)4.37150138
31positive regulation of tolerance induction (GO:0002645)4.31781656
32positive regulation of natural killer cell differentiation (GO:0032825)4.29552219
33regulation of granulocyte differentiation (GO:0030852)4.21626194
34T cell receptor signaling pathway (GO:0050852)4.14207167
35positive regulation of isotype switching (GO:0045830)4.02372835
36regulation of antigen receptor-mediated signaling pathway (GO:0050854)4.01908740
37regulation of T cell mediated cytotoxicity (GO:0001914)4.01471879
38regulation of tolerance induction (GO:0002643)3.99296709
39mast cell activation (GO:0045576)3.92972661
40antigen receptor-mediated signaling pathway (GO:0050851)3.89938225
41negative regulation of glycoprotein biosynthetic process (GO:0010561)3.88696344
42negative regulation of lymphocyte mediated immunity (GO:0002707)3.87300666
43regulation of isotype switching to IgG isotypes (GO:0048302)3.87004808
44B cell receptor signaling pathway (GO:0050853)3.86276574
45positive regulation of T cell mediated cytotoxicity (GO:0001916)3.81091321
46regulation of alpha-beta T cell proliferation (GO:0046640)3.72955676
47regulation of T cell receptor signaling pathway (GO:0050856)3.71581585
48regulation of interleukin-2 biosynthetic process (GO:0045076)3.70539750
49negative regulation of leukocyte mediated immunity (GO:0002704)3.65951893
50positive regulation of B cell differentiation (GO:0045579)3.59041869
51positive regulation of T cell differentiation in thymus (GO:0033089)3.56187712
52detection of bacterium (GO:0016045)3.52241651
53positive regulation of interleukin-4 production (GO:0032753)3.51788913
54regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.51376456
55regulation of natural killer cell mediated immunity (GO:0002715)3.51376456
56positive regulation of DNA recombination (GO:0045911)3.51353933
57interferon-gamma production (GO:0032609)3.49666916
58regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.47903489
59cytidine metabolic process (GO:0046087)3.47742652
60cytidine catabolic process (GO:0006216)3.47742652
61cytidine deamination (GO:0009972)3.47742652
62regulation of leukocyte mediated cytotoxicity (GO:0001910)3.45420785
63regulation of activation of Janus kinase activity (GO:0010533)3.45241163
64alpha-beta T cell differentiation (GO:0046632)3.44326456
65positive regulation of alpha-beta T cell proliferation (GO:0046641)3.44277413
66regulation of interleukin-4 production (GO:0032673)3.43276574
67positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.42154691
68regulation of B cell differentiation (GO:0045577)3.41253902
69response to interferon-beta (GO:0035456)3.40080587
70NIK/NF-kappaB signaling (GO:0038061)3.34707296
71detection of other organism (GO:0098543)3.33964889
72type I interferon signaling pathway (GO:0060337)3.33033075
73cellular response to type I interferon (GO:0071357)3.33033075
74response to type I interferon (GO:0034340)3.32115829
75regulation of isotype switching (GO:0045191)3.31093531
76regulation of defense response to virus by virus (GO:0050690)3.30551900
77T cell costimulation (GO:0031295)3.27413904
78T cell differentiation (GO:0030217)3.25935803
79pyrimidine ribonucleoside catabolic process (GO:0046133)3.25253597
80DNA deamination (GO:0045006)3.25242339
81lymphocyte costimulation (GO:0031294)3.23355721
82T cell homeostasis (GO:0043029)3.23225150
83lymphocyte homeostasis (GO:0002260)3.20806059
84positive regulation of immunoglobulin production (GO:0002639)3.19687065
85alpha-beta T cell activation (GO:0046631)3.14511220
86regulation of cell killing (GO:0031341)3.13963962
87negative regulation of erythrocyte differentiation (GO:0045647)3.12416421
88regulation of natural killer cell differentiation (GO:0032823)3.11313147
89signal complex assembly (GO:0007172)3.10504538
90positive regulation of cell killing (GO:0031343)3.09988095
91mast cell activation involved in immune response (GO:0002279)3.09112397
92mast cell degranulation (GO:0043303)3.09112397
93lymphocyte migration (GO:0072676)3.08467710
94regulation of alpha-beta T cell activation (GO:0046634)3.07328706
95positive regulation of B cell mediated immunity (GO:0002714)3.04453643
96positive regulation of immunoglobulin mediated immune response (GO:0002891)3.04453643
97positive regulation of T cell mediated immunity (GO:0002711)3.03878110
98regulation of T cell mediated immunity (GO:0002709)3.03620876
99positive regulation of calcium-mediated signaling (GO:0050850)3.01312991
100positive regulation of natural killer cell mediated immunity (GO:0002717)3.01214055

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_20620947_ChIP-Seq_CD4_POS_T_Human6.96343971
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse6.11869180
3IRF8_22096565_ChIP-ChIP_GC-B_Human5.08287824
4RUNX_20019798_ChIP-Seq_JUKART_Human4.10943385
5MYB_26560356_Chip-Seq_TH2_Human4.05840015
6IRF8_21731497_ChIP-ChIP_J774_Mouse3.53126535
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.29175463
8STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.24490512
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.24237498
10MYB_26560356_Chip-Seq_TH1_Human3.06641874
11MAF_26560356_Chip-Seq_TH1_Human3.01248073
12MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.99282487
13FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.99168746
14SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.87929454
15STAT4_19710469_ChIP-ChIP_TH1__Mouse2.86058457
16UTX_26944678_Chip-Seq_JUKART_Human2.80731750
17RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.70604009
18MAF_26560356_Chip-Seq_TH2_Human2.64933103
19GATA3_27048872_Chip-Seq_THYMUS_Human2.55776747
20SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.47102684
21SPI1_23547873_ChIP-Seq_NB4_Human2.35852734
22GATA3_26560356_Chip-Seq_TH2_Human2.24778173
23IRF8_27001747_Chip-Seq_BMDM_Mouse2.17744088
24MYC_22102868_ChIP-Seq_BL_Human2.17376444
25SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.11325017
26ELF1_17652178_ChIP-ChIP_JURKAT_Human2.11313906
27SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.10612022
28NOTCH1_21737748_ChIP-Seq_TLL_Human2.04781119
29E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.03391107
30SPI1_23127762_ChIP-Seq_K562_Human1.96540645
31RUNX1_22412390_ChIP-Seq_EML_Mouse1.95955550
32SMAD_19615063_ChIP-ChIP_OVARY_Human1.95647748
33CIITA_25753668_ChIP-Seq_RAJI_Human1.93668588
34FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.90464354
35FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.88103056
36NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.87887796
37BRD4_27068464_Chip-Seq_AML-cells_Mouse1.72037930
38VDR_21846776_ChIP-Seq_THP-1_Human1.69620846
39MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.69162570
40CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.64376613
41BP1_19119308_ChIP-ChIP_Hs578T_Human1.61067529
42SCL_19346495_ChIP-Seq_HPC-7_Human1.59065310
43RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.58637115
44TCF7_22412390_ChIP-Seq_EML_Mouse1.53598561
45LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.52600926
46KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.50882059
47MYB_21317192_ChIP-Seq_ERMYB_Mouse1.48129402
48VDR_24763502_ChIP-Seq_THP-1_Human1.47749085
49VDR_23849224_ChIP-Seq_CD4+_Human1.34777353
50GATA2_22383799_ChIP-Seq_G1ME_Mouse1.33653614
51NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.30559731
52KDM2B_26808549_Chip-Seq_DND41_Human1.29782530
53BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.28048286
54ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.27188796
55SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.24817670
56RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.23238119
57KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.20770808
58KDM2B_26808549_Chip-Seq_SUP-B15_Human1.16748342
59TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.15577362
60GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.15372499
61LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.14826008
62FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12720781
63VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.08984336
64CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.08906341
65KDM2B_26808549_Chip-Seq_JURKAT_Human1.08522445
66TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08067772
67RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.07845563
68TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.06877032
69NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.99991110
70PU.1_20513432_ChIP-Seq_Bcells_Mouse0.99794567
71GATA3_26560356_Chip-Seq_TH1_Human0.97800152
72SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97399350
73BCL6_27268052_Chip-Seq_Bcells_Human0.93445230
74GATA1_22383799_ChIP-Seq_G1ME_Mouse0.93110948
75CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.91277021
76CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.87355271
77CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.85874294
78HOXB4_20404135_ChIP-ChIP_EML_Mouse0.85193976
79TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.84976708
80CTCF_27219007_Chip-Seq_ERYTHROID_Human0.84892512
81PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.84817101
82EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.83967957
83PU_27001747_Chip-Seq_BMDM_Mouse0.83536881
84FOXP3_21729870_ChIP-Seq_TREG_Human0.82818577
85RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80703211
86GATA1_19941827_ChIP-Seq_MEL_Mouse0.80538465
87GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80531667
88GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78016127
89PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.77262539
90STAT6_21828071_ChIP-Seq_BEAS2B_Human0.77068779
91BCOR_27268052_Chip-Seq_Bcells_Human0.76614100
92NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.76432842
93PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.75187658
94STAT1_20625510_ChIP-Seq_HELA_Human0.75097730
95CTCF_21964334_ChIP-Seq_BJAB-B_Human0.74539933
96CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.73699154
97SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.72728951
98GATA1_19941826_ChIP-Seq_K562_Human0.71556040
99STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.71292583
100ELK3_25401928_ChIP-Seq_HUVEC_Human0.70117381

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology5.56361188
2MP0005671_abnormal_response_to4.64055383
3MP0001873_stomach_inflammation3.59875766
4MP0000685_abnormal_immune_system3.56947029
5MP0003436_decreased_susceptibility_to3.40481515
6MP0001790_abnormal_immune_system3.34060187
7MP0005387_immune_system_phenotype3.34060187
8MP0001835_abnormal_antigen_presentation3.24173174
9MP0001800_abnormal_humoral_immune3.20433543
10MP0008057_abnormal_DNA_replication3.08446147
11MP0005000_abnormal_immune_tolerance2.88957712
12MP0003724_increased_susceptibility_to2.88952934
13MP0009333_abnormal_splenocyte_physiolog2.88411824
14MP0002420_abnormal_adaptive_immunity2.68654794
15MP0001819_abnormal_immune_cell2.63901951
16MP0002723_abnormal_immune_serum2.60557216
17MP0005025_abnormal_response_to2.50661142
18MP0000703_abnormal_thymus_morphology2.41424372
19MP0009785_altered_susceptibility_to2.36932495
20MP0002452_abnormal_antigen_presenting2.34594474
21MP0002398_abnormal_bone_marrow2.32547403
22MP0003866_abnormal_defecation2.23375635
23MP0004381_abnormal_hair_follicle2.22467319
24MP0002405_respiratory_system_inflammati2.20428806
25MP0000716_abnormal_immune_system2.14860317
26MP0002419_abnormal_innate_immunity2.11636428
27MP0002148_abnormal_hypersensitivity_rea2.00403324
28MP0002396_abnormal_hematopoietic_system1.99372862
29MP0003191_abnormal_cellular_cholesterol1.97936761
30MP0004947_skin_inflammation1.97802319
31MP0002722_abnormal_immune_system1.95023094
32MP0000465_gastrointestinal_hemorrhage1.94373585
33MP0000689_abnormal_spleen_morphology1.89017562
34MP0005075_abnormal_melanosome_morpholog1.86100832
35MP0001853_heart_inflammation1.85879133
36MP0010155_abnormal_intestine_physiology1.84680922
37MP0001533_abnormal_skeleton_physiology1.79681825
38MP0003303_peritoneal_inflammation1.76684244
39MP0002166_altered_tumor_susceptibility1.75170019
40MP0003300_gastrointestinal_ulcer1.75145273
41MP0002429_abnormal_blood_cell1.66883773
42MP0000858_altered_metastatic_potential1.60814472
43MP0009278_abnormal_bone_marrow1.57911692
44MP0001845_abnormal_inflammatory_respons1.57628264
45MP0005464_abnormal_platelet_physiology1.56732820
46MP0001851_eye_inflammation1.55194333
47MP0002277_abnormal_respiratory_mucosa1.46321536
48MP0006082_CNS_inflammation1.38790700
49MP0003172_abnormal_lysosome_physiology1.34144913
50MP0009840_abnormal_foam_cell1.28686124
51MP0002933_joint_inflammation1.27670388
52MP0002653_abnormal_ependyma_morphology1.26981147
53MP0002006_tumorigenesis1.21977247
54MP0005310_abnormal_salivary_gland1.20469687
55MP0002138_abnormal_hepatobiliary_system1.16889632
56MP0002009_preneoplasia1.15600658
57MP0001663_abnormal_digestive_system1.12165042
58MP0004510_myositis1.05795195
59MP0008469_abnormal_protein_level1.00132261
60MP0000604_amyloidosis0.96216937
61MP0001348_abnormal_lacrimal_gland0.96162765
62MP0001986_abnormal_taste_sensitivity0.95237454
63MP0000490_abnormal_crypts_of0.90547577
64MP0003329_amyloid_beta_deposits0.88316272
65MP0004130_abnormal_muscle_cell0.83254289
66MP0009763_increased_sensitivity_to0.81160986
67MP0002019_abnormal_tumor_incidence0.81053670
68MP0003448_altered_tumor_morphology0.76352334
69MP0002998_abnormal_bone_remodeling0.74832048
70MP0005390_skeleton_phenotype0.74411516
71MP0009764_decreased_sensitivity_to0.71173181
72MP0005397_hematopoietic_system_phenotyp0.66252179
73MP0001545_abnormal_hematopoietic_system0.66252179
74MP0002098_abnormal_vibrissa_morphology0.65827891
75MP0002693_abnormal_pancreas_physiology0.65791280
76MP0008995_early_reproductive_senescence0.65586825
77MP0001919_abnormal_reproductive_system0.65545446
78MP0002132_abnormal_respiratory_system0.63722612
79MP0003646_muscle_fatigue0.63032662
80MP0003786_premature_aging0.59552710
81MP0005381_digestive/alimentary_phenotyp0.58816467
82MP0003795_abnormal_bone_structure0.56315395
83MP0002163_abnormal_gland_morphology0.54355358
84MP0004883_abnormal_blood_vessel0.53791020
85MP0001765_abnormal_ion_homeostasis0.49541609
86MP0001243_abnormal_dermal_layer0.47195314
87MP0003045_fibrosis0.45418327
88MP0005166_decreased_susceptibility_to0.43292880
89MP0004484_altered_response_of0.41159364
90MP0000609_abnormal_liver_physiology0.41103806
91MP0008961_abnormal_basal_metabolism0.39917386
92MP0003656_abnormal_erythrocyte_physiolo0.39271386
93MP0003091_abnormal_cell_migration0.38674305
94MP0004808_abnormal_hematopoietic_stem0.37282943
95MP0004147_increased_porphyrin_level0.36781083
96MP0003638_abnormal_response/metabolism_0.35594638
97MP0003880_abnormal_central_pattern0.35520781
98MP0004134_abnormal_chest_morphology0.34513250
99MP0009643_abnormal_urine_homeostasis0.33649038
100MP0000249_abnormal_blood_vessel0.33483902

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)8.36717375
2Stomatitis (HP:0010280)7.65080568
3T lymphocytopenia (HP:0005403)6.13926732
4Abnormality of T cell number (HP:0011839)5.85801926
5Eczematoid dermatitis (HP:0000976)5.38613863
6Myositis (HP:0100614)5.21192644
7Autoimmune hemolytic anemia (HP:0001890)5.13582340
8Severe combined immunodeficiency (HP:0004430)4.78382157
9Pustule (HP:0200039)4.67892258
10IgG deficiency (HP:0004315)4.59478349
11Abnormality of T cells (HP:0002843)4.50036622
12Increased IgM level (HP:0003496)4.27300502
13Abnormal delayed hypersensitivity skin test (HP:0002963)3.88419297
14Recurrent fungal infections (HP:0002841)3.86129730
15Combined immunodeficiency (HP:0005387)3.85002606
16Abnormality of eosinophils (HP:0001879)3.78402895
17Orchitis (HP:0100796)3.61607414
18Recurrent abscess formation (HP:0002722)3.58628295
19Abnormality of macrophages (HP:0004311)3.50416752
20Leukocytosis (HP:0001974)3.48473360
21Recurrent bacterial skin infections (HP:0005406)3.47584502
22Retrobulbar optic neuritis (HP:0100654)3.36613591
23Optic neuritis (HP:0100653)3.36613591
24Mediastinal lymphadenopathy (HP:0100721)3.34224307
25Granulocytopenia (HP:0001913)3.26420949
26Eosinophilia (HP:0001880)3.22924506
27Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.15438331
28Abnormality of T cell physiology (HP:0011840)3.12881572
29Vasculitis (HP:0002633)3.11218900
30Lymphopenia (HP:0001888)3.08834523
31Encephalitis (HP:0002383)3.07551522
32Chronic mucocutaneous candidiasis (HP:0002728)3.06848982
33Recurrent cutaneous fungal infections (HP:0011370)3.06848982
34Meningitis (HP:0001287)3.06447819
35Panhypogammaglobulinemia (HP:0003139)3.03375089
36Increased IgE level (HP:0003212)3.03097955
37Gastrointestinal infarctions (HP:0005244)3.02797706
38Recurrent bronchitis (HP:0002837)3.01627757
39Hypergammaglobulinemia (HP:0010702)2.99701317
40Abnormality of cells of the lymphoid lineage (HP:0012140)2.97392874
41Aplastic anemia (HP:0001915)2.93795752
42Pulmonary infiltrates (HP:0002113)2.90598182
43Spontaneous hematomas (HP:0007420)2.89657176
44Inflammation of the large intestine (HP:0002037)2.86931335
45IgM deficiency (HP:0002850)2.86846629
46Episodic fever (HP:0001954)2.82575724
47Hypochromic anemia (HP:0001931)2.80463119
48Gastrointestinal inflammation (HP:0004386)2.79277940
49Keratoconjunctivitis sicca (HP:0001097)2.75974928
50Obstructive lung disease (HP:0006536)2.74994605
51Chronic obstructive pulmonary disease (HP:0006510)2.74994605
52Thyroiditis (HP:0100646)2.73790903
53Recurrent viral infections (HP:0004429)2.72880219
54Prolonged bleeding time (HP:0003010)2.70170206
55Stomach cancer (HP:0012126)2.68802669
56Recurrent skin infections (HP:0001581)2.60559594
57Limb hypertonia (HP:0002509)2.56971311
58Keratoconjunctivitis (HP:0001096)2.54018147
59Hypoplasia of the thymus (HP:0000778)2.53851109
60Chronic diarrhea (HP:0002028)2.49781249
61Recurrent gram-negative bacterial infections (HP:0005420)2.46657950
62Chest pain (HP:0100749)2.42779459
63Abnormality of the prostate (HP:0008775)2.42447786
64Joint swelling (HP:0001386)2.40931968
65Petechiae (HP:0000967)2.40688340
66Abnormality of the pleura (HP:0002103)2.35553824
67Lymphoma (HP:0002665)2.29323201
68Anorexia (HP:0002039)2.28130206
69Ileus (HP:0002595)2.25553488
70Hemoptysis (HP:0002105)2.23799984
71Verrucae (HP:0200043)2.23779286
72Papilloma (HP:0012740)2.23779286
73Urticaria (HP:0001025)2.21851839
74Hypochromic microcytic anemia (HP:0004840)2.21401274
75Pulmonary embolism (HP:0002204)2.21211355
76Prostate neoplasm (HP:0100787)2.14080250
77Epistaxis (HP:0000421)2.13919655
78Absent rod-and cone-mediated responses on ERG (HP:0007688)2.13858022
79Gingivitis (HP:0000230)2.11119067
80Basal cell carcinoma (HP:0002671)2.10058466
81Microcytic anemia (HP:0001935)2.09617554
82Papilledema (HP:0001085)2.06320049
83Interstitial pulmonary disease (HP:0006530)2.02335857
84Agammaglobulinemia (HP:0004432)2.00104026
85Abnormality of B cell number (HP:0010975)1.97581570
86Gangrene (HP:0100758)1.97218084
87Bronchitis (HP:0012387)1.94672435
88Sepsis (HP:0100806)1.90530253
89Hypoproteinemia (HP:0003075)1.90431502
90Decreased circulating renin level (HP:0003351)1.88502833
91Easy fatigability (HP:0003388)1.87948370
92Purpura (HP:0000979)1.87272255
93Autoimmune thrombocytopenia (HP:0001973)1.85839673
94Hyperlipoproteinemia (HP:0010980)1.81345502
95Hematochezia (HP:0002573)1.79202042
96Acute hepatic failure (HP:0006554)1.78230500
97Aortic regurgitation (HP:0001659)1.74222319
98Hepatosplenomegaly (HP:0001433)1.74026596
99Thrombocytosis (HP:0001894)1.72951481
100Nasal polyposis (HP:0100582)1.71853432

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK6.19260283
2MAP4K14.87023969
3MUSK3.58949741
4SCYL23.53745791
5BTK2.72639175
6ZAP702.63840461
7NLK2.61717500
8ITK2.59742418
9GRK62.46391714
10FES2.38218473
11CSK2.31952295
12JAK12.30562126
13SYK2.25611058
14TYK22.09909133
15TEC2.04873457
16RIPK41.97387342
17HCK1.90716650
18SIK31.72509302
19KDR1.71933688
20LCK1.70267807
21JAK31.66249938
22PRPF4B1.62024842
23VRK21.50966319
24CAMKK21.43563169
25IRAK41.43209452
26FGFR41.36964030
27TNK21.36793243
28TAOK31.27980285
29TESK21.27875032
30PASK1.26074243
31MAP3K141.24689810
32MAPKAPK31.22132854
33FGFR31.22081427
34LYN1.17967872
35ERN11.15056605
36IKBKE1.11196903
37MST41.10923355
38PDK21.05018966
39CSF1R1.02658567
40EPHB10.99502243
41CAMKK10.94077062
42TBK10.93934250
43STK100.93613442
44CLK10.92876756
45JAK20.88572305
46HIPK20.88355217
47MAP2K30.85156081
48MARK30.84824547
49FGR0.84810620
50TYRO30.82300820
51MAP3K110.77880919
52PIM10.77590451
53PDK10.77072479
54PRKCQ0.72704622
55BLK0.68132603
56IKBKB0.66203110
57STK380.66080557
58EPHA30.65078162
59MAP3K10.64023967
60TGFBR20.61547823
61FYN0.60298857
62MAPK120.59975973
63MAPKAPK20.56580739
64FGFR20.55228490
65MAP3K130.54623563
66CDK190.54219125
67SIK20.53650063
68CDK80.52552940
69PRKCH0.51691106
70PDGFRB0.50574080
71LRRK20.49719926
72TESK10.47751699
73TLK10.46437105
74MAPK110.43186116
75KIT0.42092522
76TAOK10.42029319
77MAPK70.41856473
78MAP3K30.40873313
79TAOK20.39038969
80RPS6KA40.37564666
81GRK70.35803019
82MAP3K70.34489852
83CDK120.32216838
84NEK90.31843124
85SMG10.29318939
86CDK40.27627916
87PTK60.24179904
88PIK3CG0.23980370
89ADRBK20.23857876
90MAPK130.23568037
91NTRK20.23367239
92MAPK30.23331369
93IGF1R0.22730933
94MAPK90.22303895
95PDPK10.21642501
96MELK0.19976165
97NUAK10.19086907
98DAPK10.18432227
99YES10.17007823
100MAP3K100.17000033

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.52479037
2T cell receptor signaling pathway_Homo sapiens_hsa046604.16323780
3Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046503.50237319
4Hematopoietic cell lineage_Homo sapiens_hsa046402.73600210
5Autoimmune thyroid disease_Homo sapiens_hsa053202.73435801
6Allograft rejection_Homo sapiens_hsa053302.58011787
7Graft-versus-host disease_Homo sapiens_hsa053322.45967435
8Osteoclast differentiation_Homo sapiens_hsa043802.45124652
9Measles_Homo sapiens_hsa051622.45033916
10NF-kappa B signaling pathway_Homo sapiens_hsa040642.31560101
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.23092029
12B cell receptor signaling pathway_Homo sapiens_hsa046622.16488186
13Jak-STAT signaling pathway_Homo sapiens_hsa046302.04657323
14Intestinal immune network for IgA production_Homo sapiens_hsa046721.94086228
15Antigen processing and presentation_Homo sapiens_hsa046121.90279585
16Acute myeloid leukemia_Homo sapiens_hsa052211.74765265
17Malaria_Homo sapiens_hsa051441.65793027
18RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.62024394
19Herpes simplex infection_Homo sapiens_hsa051681.59681876
20Type I diabetes mellitus_Homo sapiens_hsa049401.59193033
21Viral myocarditis_Homo sapiens_hsa054161.56375608
22Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.55373280
23Staphylococcus aureus infection_Homo sapiens_hsa051501.53131033
24Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.50445984
25Chemokine signaling pathway_Homo sapiens_hsa040621.48103135
26Leishmaniasis_Homo sapiens_hsa051401.42367821
27Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.41749196
28Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.39005981
29HTLV-I infection_Homo sapiens_hsa051661.30878822
30NOD-like receptor signaling pathway_Homo sapiens_hsa046211.29086184
31Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.27107715
32Hepatitis B_Homo sapiens_hsa051611.22584830
33Leukocyte transendothelial migration_Homo sapiens_hsa046701.21403765
34Regulation of autophagy_Homo sapiens_hsa041401.12632937
35Shigellosis_Homo sapiens_hsa051311.11563253
36Toxoplasmosis_Homo sapiens_hsa051451.10748995
37TNF signaling pathway_Homo sapiens_hsa046681.10434214
38Platelet activation_Homo sapiens_hsa046111.09397669
39Toll-like receptor signaling pathway_Homo sapiens_hsa046201.07343083
40Tuberculosis_Homo sapiens_hsa051521.04895671
41Non-small cell lung cancer_Homo sapiens_hsa052231.04427437
42Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.00817584
43VEGF signaling pathway_Homo sapiens_hsa043700.96747891
44Influenza A_Homo sapiens_hsa051640.94848208
45Viral carcinogenesis_Homo sapiens_hsa052030.92987054
46SNARE interactions in vesicular transport_Homo sapiens_hsa041300.91476365
47Ribosome_Homo sapiens_hsa030100.87908414
48Asthma_Homo sapiens_hsa053100.87820486
49Epstein-Barr virus infection_Homo sapiens_hsa051690.86904191
50Pancreatic cancer_Homo sapiens_hsa052120.82000691
51Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.77956026
52FoxO signaling pathway_Homo sapiens_hsa040680.75272963
53African trypanosomiasis_Homo sapiens_hsa051430.74453424
54Colorectal cancer_Homo sapiens_hsa052100.74253983
55Phosphatidylinositol signaling system_Homo sapiens_hsa040700.73905841
56Rheumatoid arthritis_Homo sapiens_hsa053230.69380819
57Glycerophospholipid metabolism_Homo sapiens_hsa005640.68877428
58Dorso-ventral axis formation_Homo sapiens_hsa043200.68174127
59Renal cell carcinoma_Homo sapiens_hsa052110.67280407
60Apoptosis_Homo sapiens_hsa042100.67020523
61AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.64997996
62Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.63814299
63Hepatitis C_Homo sapiens_hsa051600.63500345
64Prolactin signaling pathway_Homo sapiens_hsa049170.62205416
65Insulin resistance_Homo sapiens_hsa049310.59764843
66Basal transcription factors_Homo sapiens_hsa030220.59732718
67Endocytosis_Homo sapiens_hsa041440.58633068
68Thyroid cancer_Homo sapiens_hsa052160.56957302
69Endometrial cancer_Homo sapiens_hsa052130.47073332
70Glycerolipid metabolism_Homo sapiens_hsa005610.46256937
71MAPK signaling pathway_Homo sapiens_hsa040100.45671933
72Neurotrophin signaling pathway_Homo sapiens_hsa047220.43561152
73Legionellosis_Homo sapiens_hsa051340.43252316
74Chronic myeloid leukemia_Homo sapiens_hsa052200.42857194
75Phospholipase D signaling pathway_Homo sapiens_hsa040720.41648197
76Choline metabolism in cancer_Homo sapiens_hsa052310.40713064
77mTOR signaling pathway_Homo sapiens_hsa041500.40559727
78Inositol phosphate metabolism_Homo sapiens_hsa005620.40478446
79Sphingolipid signaling pathway_Homo sapiens_hsa040710.40320954
80Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.39290446
81Phagosome_Homo sapiens_hsa041450.36003051
82Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.35262674
83Transcriptional misregulation in cancer_Homo sapiens_hsa052020.32777884
84Pertussis_Homo sapiens_hsa051330.32646665
85Long-term potentiation_Homo sapiens_hsa047200.32326623
86Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.30456880
87Rap1 signaling pathway_Homo sapiens_hsa040150.30071328
88Adipocytokine signaling pathway_Homo sapiens_hsa049200.29671355
89Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.29577056
90RNA degradation_Homo sapiens_hsa030180.27725966
91Prostate cancer_Homo sapiens_hsa052150.27361714
92Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.27010958
93Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.26718567
94GnRH signaling pathway_Homo sapiens_hsa049120.25924871
95Ras signaling pathway_Homo sapiens_hsa040140.22670844
96Salmonella infection_Homo sapiens_hsa051320.22135630
97Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.21983547
98Nitrogen metabolism_Homo sapiens_hsa009100.21080297
99Regulation of actin cytoskeleton_Homo sapiens_hsa048100.20903619
100Spliceosome_Homo sapiens_hsa030400.18593099

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