TRBV5-4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.37910714
2negative T cell selection (GO:0043383)6.24851653
3positive regulation of gamma-delta T cell activation (GO:0046645)6.23200572
4negative thymic T cell selection (GO:0045060)6.15484948
5tolerance induction (GO:0002507)6.07952497
6negative regulation of cell killing (GO:0031342)6.04138107
7negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.04138107
8positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.93977825
9antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.78701755
10regulation of regulatory T cell differentiation (GO:0045589)5.45376253
11antigen processing and presentation of endogenous antigen (GO:0019883)5.21697809
12antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.11581145
13response to interleukin-15 (GO:0070672)5.02329050
14T cell migration (GO:0072678)4.82699911
15cellular response to interleukin-15 (GO:0071350)4.82575201
16regulation of gamma-delta T cell differentiation (GO:0045586)4.78721460
17activated T cell proliferation (GO:0050798)4.73837595
18regulation of B cell receptor signaling pathway (GO:0050855)4.71099668
19thymic T cell selection (GO:0045061)4.68238364
20positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.62573157
21positive regulation of granulocyte differentiation (GO:0030854)4.61717427
22T cell selection (GO:0045058)4.53388398
23regulation of T cell tolerance induction (GO:0002664)4.53354581
24leukocyte aggregation (GO:0070486)4.50091104
25regulation of gamma-delta T cell activation (GO:0046643)4.49314689
26neutrophil activation involved in immune response (GO:0002283)4.33315091
27regulation of alpha-beta T cell proliferation (GO:0046640)4.23544122
28positive T cell selection (GO:0043368)4.21900641
29positive regulation of tolerance induction (GO:0002645)4.16487891
30negative regulation of T cell mediated immunity (GO:0002710)4.13633158
31regulation of isotype switching to IgG isotypes (GO:0048302)4.12368187
32positive thymic T cell selection (GO:0045059)4.12274620
33mast cell activation (GO:0045576)3.96837712
34positive regulation of alpha-beta T cell proliferation (GO:0046641)3.95941242
35regulation of tolerance induction (GO:0002643)3.92939892
36positive regulation of B cell differentiation (GO:0045579)3.86499516
37negative regulation of lymphocyte mediated immunity (GO:0002707)3.86323362
38G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.82290672
39regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.81104341
40regulation of natural killer cell mediated immunity (GO:0002715)3.81104341
41positive regulation of interleukin-4 production (GO:0032753)3.74761305
42T cell receptor signaling pathway (GO:0050852)3.74290096
43antigen processing and presentation via MHC class Ib (GO:0002475)3.71993754
44regulation of interleukin-2 biosynthetic process (GO:0045076)3.67608469
45antigen receptor-mediated signaling pathway (GO:0050851)3.61887602
46positive regulation of T cell differentiation in thymus (GO:0033089)3.57739785
47negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.49295091
48regulation of T cell mediated cytotoxicity (GO:0001914)3.44155017
49positive regulation of T cell mediated cytotoxicity (GO:0001916)3.42704891
50positive regulation of natural killer cell mediated immunity (GO:0002717)3.42069620
51regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.42068741
52regulation of B cell differentiation (GO:0045577)3.41919707
53neutrophil activation (GO:0042119)3.36189267
54T cell costimulation (GO:0031295)3.35699325
55B cell receptor signaling pathway (GO:0050853)3.35171405
56positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.34609233
57negative regulation of leukocyte mediated immunity (GO:0002704)3.33463347
58positive regulation of macrophage differentiation (GO:0045651)3.32169003
59lymphocyte costimulation (GO:0031294)3.31397049
60leukocyte degranulation (GO:0043299)3.29306998
61cellular extravasation (GO:0045123)3.25967084
62regulation of leukocyte mediated cytotoxicity (GO:0001910)3.25695516
63dendritic cell chemotaxis (GO:0002407)3.25654631
64negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.25075627
65negative regulation of T-helper cell differentiation (GO:0045623)3.25075627
66type I interferon signaling pathway (GO:0060337)3.21669832
67cellular response to type I interferon (GO:0071357)3.21669832
68regulation of interleukin-4 production (GO:0032673)3.20677886
69T cell homeostasis (GO:0043029)3.19577498
70response to type I interferon (GO:0034340)3.19216449
71regulation of defense response to virus by virus (GO:0050690)3.17796646
72negative regulation of T cell apoptotic process (GO:0070233)3.15644326
73detection of bacterium (GO:0016045)3.14631669
74mast cell activation involved in immune response (GO:0002279)3.14230588
75mast cell degranulation (GO:0043303)3.14230588
76positive regulation of isotype switching (GO:0045830)3.13910631
77negative regulation of stress fiber assembly (GO:0051497)3.09962849
78lymphocyte migration (GO:0072676)3.08136038
79alpha-beta T cell differentiation (GO:0046632)3.04263853
80positive regulation of interleukin-2 production (GO:0032743)3.03965698
81positive regulation of T cell mediated immunity (GO:0002711)3.03371103
82detection of other organism (GO:0098543)3.02923920
83regulation of granulocyte differentiation (GO:0030852)3.02259124
84alpha-beta T cell activation (GO:0046631)3.02059688
85negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.01648318
86positive regulation of cell killing (GO:0031343)3.00050463
87positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.99889023
88dendritic cell migration (GO:0036336)2.99546871
89regulation of isotype switching (GO:0045191)2.99372092
90interferon-gamma production (GO:0032609)2.98706360
91immunoglobulin mediated immune response (GO:0016064)2.96870300
92granulocyte activation (GO:0036230)2.94775792
93regulation of T cell cytokine production (GO:0002724)2.93989503
94negative regulation of erythrocyte differentiation (GO:0045647)2.93646896
95regulation of T cell mediated immunity (GO:0002709)2.93125256
96leukocyte migration involved in inflammatory response (GO:0002523)2.92826410
97positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.92615642
98regulation of cell killing (GO:0031341)2.91737063
99positive regulation of immunoglobulin mediated immune response (GO:0002891)2.88802603
100positive regulation of B cell mediated immunity (GO:0002714)2.88802603

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse6.44760243
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human6.03541715
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.82103640
4RUNX_20019798_ChIP-Seq_JUKART_Human3.75477394
5MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.69329155
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.42005860
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.40775398
8MYB_26560356_Chip-Seq_TH2_Human3.28350999
9IRF8_21731497_ChIP-ChIP_J774_Mouse3.23094274
10STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.03207764
11FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.01401694
12SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.90300085
13RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.83236661
14STAT4_19710469_ChIP-ChIP_TH1__Mouse2.78674274
15MAF_26560356_Chip-Seq_TH1_Human2.63028730
16UTX_26944678_Chip-Seq_JUKART_Human2.62998752
17ELF1_17652178_ChIP-ChIP_JURKAT_Human2.62179561
18SCL_19346495_ChIP-Seq_HPC-7_Human2.61447982
19MYB_26560356_Chip-Seq_TH1_Human2.58428278
20SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.44646932
21LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.39194548
22MYB_21317192_ChIP-Seq_ERMYB_Mouse2.32107841
23GATA3_27048872_Chip-Seq_THYMUS_Human2.28118508
24SPI1_23547873_ChIP-Seq_NB4_Human2.27146379
25MYC_22102868_ChIP-Seq_BL_Human2.26931095
26NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.26886448
27IRF8_27001747_Chip-Seq_BMDM_Mouse2.24691153
28E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.24326820
29RUNX1_22412390_ChIP-Seq_EML_Mouse2.23450904
30BP1_19119308_ChIP-ChIP_Hs578T_Human2.12251138
31SPI1_23127762_ChIP-Seq_K562_Human2.05683891
32MAF_26560356_Chip-Seq_TH2_Human2.04884898
33MEIS1_20887958_ChIP-Seq_HPC-7_Mouse2.00668096
34LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.91430317
35SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.83742731
36SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.80934506
37VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.79214637
38SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.78275383
39SMAD_19615063_ChIP-ChIP_OVARY_Human1.78150572
40GATA3_26560356_Chip-Seq_TH2_Human1.76542135
41FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.75269573
42GATA1_22025678_ChIP-Seq_K562_Human1.71267027
43VDR_24763502_ChIP-Seq_THP-1_Human1.71027811
44BRD4_27068464_Chip-Seq_AML-cells_Mouse1.66648145
45TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.66644743
46VDR_21846776_ChIP-Seq_THP-1_Human1.59123356
47TCF7_22412390_ChIP-Seq_EML_Mouse1.57796993
48GATA1_19941827_ChIP-Seq_MEL_Mouse1.52207702
49GATA1_19941826_ChIP-Seq_K562_Human1.52192162
50GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.49153982
51KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.48701246
52TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.45483141
53GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.41798856
54RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.39550886
55GATA1_22383799_ChIP-Seq_G1ME_Mouse1.34584108
56NOTCH1_21737748_ChIP-Seq_TLL_Human1.32838276
57GATA2_22383799_ChIP-Seq_G1ME_Mouse1.26819966
58SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.22726015
59KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.22437053
60Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.21198302
61KDM2B_26808549_Chip-Seq_DND41_Human1.20468953
62CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.18437151
63KDM2B_26808549_Chip-Seq_SUP-B15_Human1.17887129
64PU_27001747_Chip-Seq_BMDM_Mouse1.15996987
65CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15832032
66E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.14956884
67GATA2_19941826_ChIP-Seq_K562_Human1.13955532
68ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.12506449
69CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11785920
70PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11760901
71RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.10275986
72GATA2_21666600_ChIP-Seq_HMVEC_Human1.09583250
73PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.07779696
74CIITA_25753668_ChIP-Seq_RAJI_Human1.06147978
75NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.05773190
76FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04789712
77KDM2B_26808549_Chip-Seq_JURKAT_Human1.01710503
78PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99866065
79HOXB4_20404135_ChIP-ChIP_EML_Mouse0.99343963
80GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97676309
81RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95624481
82NCOR1_26117541_ChIP-Seq_K562_Human0.95374893
83STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.94296844
84SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.92724717
85PU.1_20513432_ChIP-Seq_Bcells_Mouse0.90617949
86ELK3_25401928_ChIP-Seq_HUVEC_Human0.89829038
87VDR_24787735_ChIP-Seq_THP-1_Human0.89315086
88CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.89068785
89VDR_23849224_ChIP-Seq_CD4+_Human0.88104297
90NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.87673211
91BCL6_27268052_Chip-Seq_Bcells_Human0.87438276
92TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.85439448
93CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.84832923
94SPI1_20517297_ChIP-Seq_HL60_Human0.84672966
95GATA3_26560356_Chip-Seq_TH1_Human0.83564448
96FOXP3_21729870_ChIP-Seq_TREG_Human0.81101104
97PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.78156406
98EGR1_19374776_ChIP-ChIP_THP-1_Human0.78039527
99BCOR_27268052_Chip-Seq_Bcells_Human0.77709547
100CTCF_27219007_Chip-Seq_ERYTHROID_Human0.76663624

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology4.76243050
2MP0005671_abnormal_response_to4.33321788
3MP0005464_abnormal_platelet_physiology3.98348195
4MP0001835_abnormal_antigen_presentation3.81572195
5MP0003724_increased_susceptibility_to3.58033591
6MP0003436_decreased_susceptibility_to3.51451888
7MP0001800_abnormal_humoral_immune3.18433524
8MP0005000_abnormal_immune_tolerance3.13693029
9MP0009333_abnormal_splenocyte_physiolog2.78763320
10MP0002723_abnormal_immune_serum2.74785568
11MP0005387_immune_system_phenotype2.74032822
12MP0001790_abnormal_immune_system2.74032822
13MP0002420_abnormal_adaptive_immunity2.69871151
14MP0001819_abnormal_immune_cell2.65463406
15MP0000685_abnormal_immune_system2.61064370
16MP0002148_abnormal_hypersensitivity_rea2.58491035
17MP0005025_abnormal_response_to2.57677375
18MP0002452_abnormal_antigen_presenting2.54110808
19MP0002398_abnormal_bone_marrow2.53952923
20MP0009785_altered_susceptibility_to2.51706268
21MP0000465_gastrointestinal_hemorrhage2.48646055
22MP0010155_abnormal_intestine_physiology2.42174282
23MP0003866_abnormal_defecation2.35505375
24MP0003303_peritoneal_inflammation2.34177603
25MP0001873_stomach_inflammation2.33877541
26MP0000703_abnormal_thymus_morphology2.33104258
27MP0002419_abnormal_innate_immunity2.27728378
28MP0002405_respiratory_system_inflammati2.27241027
29MP0000716_abnormal_immune_system2.21436145
30MP0003300_gastrointestinal_ulcer2.11388580
31MP0000689_abnormal_spleen_morphology1.99786809
32MP0002722_abnormal_immune_system1.98556288
33MP0004947_skin_inflammation1.94615089
34MP0001851_eye_inflammation1.93234067
35MP0002429_abnormal_blood_cell1.81227287
36MP0004381_abnormal_hair_follicle1.79421101
37MP0001845_abnormal_inflammatory_respons1.73531326
38MP0006082_CNS_inflammation1.68415458
39MP0001533_abnormal_skeleton_physiology1.64794481
40MP0005310_abnormal_salivary_gland1.50779424
41MP0008004_abnormal_stomach_pH1.49574374
42MP0002166_altered_tumor_susceptibility1.38955890
43MP0005075_abnormal_melanosome_morpholog1.36712057
44MP0004510_myositis1.34065168
45MP0000858_altered_metastatic_potential1.30875043
46MP0000490_abnormal_crypts_of1.23760739
47MP0002132_abnormal_respiratory_system1.23124311
48MP0008469_abnormal_protein_level1.22406594
49MP0002396_abnormal_hematopoietic_system1.20484264
50MP0002277_abnormal_respiratory_mucosa1.13211777
51MP0009763_increased_sensitivity_to1.11912876
52MP0003183_abnormal_peptide_metabolism1.08355838
53MP0001663_abnormal_digestive_system1.07986567
54MP0004130_abnormal_muscle_cell1.05417142
55MP0009278_abnormal_bone_marrow1.04404552
56MP0002138_abnormal_hepatobiliary_system1.04033088
57MP0009764_decreased_sensitivity_to1.02863020
58MP0005451_abnormal_body_composition1.02732590
59MP0003828_pulmonary_edema1.01976673
60MP0003191_abnormal_cellular_cholesterol1.00747398
61MP0008260_abnormal_autophagy0.98857847
62MP0002933_joint_inflammation0.96077504
63MP0002998_abnormal_bone_remodeling0.91487585
64MP0002006_tumorigenesis0.89672750
65MP0001348_abnormal_lacrimal_gland0.87002246
66MP0003172_abnormal_lysosome_physiology0.85679040
67MP0002163_abnormal_gland_morphology0.84225878
68MP0009765_abnormal_xenobiotic_induced0.82465303
69MP0003045_fibrosis0.80161725
70MP0002019_abnormal_tumor_incidence0.76518929
71MP0000343_altered_response_to0.76374397
72MP0000249_abnormal_blood_vessel0.72862596
73MP0001853_heart_inflammation0.72611177
74MP0004808_abnormal_hematopoietic_stem0.72370881
75MP0002693_abnormal_pancreas_physiology0.69396413
76MP0002009_preneoplasia0.69252263
77MP0001545_abnormal_hematopoietic_system0.64790640
78MP0005397_hematopoietic_system_phenotyp0.64790640
79MP0003448_altered_tumor_morphology0.62054314
80MP0005166_decreased_susceptibility_to0.60686934
81MP0005381_digestive/alimentary_phenotyp0.60203359
82MP0008569_lethality_at_weaning0.58590927
83MP0008874_decreased_physiological_sensi0.57782180
84MP0005083_abnormal_biliary_tract0.57101450
85MP0001765_abnormal_ion_homeostasis0.56443772
86MP0005390_skeleton_phenotype0.56377991
87MP0003091_abnormal_cell_migration0.54900490
88MP0009642_abnormal_blood_homeostasis0.52836694
89MP0003795_abnormal_bone_structure0.51686438
90MP0008961_abnormal_basal_metabolism0.50409123
91MP0004883_abnormal_blood_vessel0.49838776
92MP0008872_abnormal_physiological_respon0.49708308
93MP0005058_abnormal_lysosome_morphology0.48536550
94MP0001919_abnormal_reproductive_system0.48079809
95MP0000015_abnormal_ear_pigmentation0.47652034
96MP0003638_abnormal_response/metabolism_0.42744885
97MP0009840_abnormal_foam_cell0.42139062
98MP0000230_abnormal_systemic_arterial0.41389128
99MP0002136_abnormal_kidney_physiology0.39712528
100MP0005410_abnormal_fertilization0.39220489

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)6.17671930
2Prolonged bleeding time (HP:0003010)6.15015002
3Elevated erythrocyte sedimentation rate (HP:0003565)5.43732581
4T lymphocytopenia (HP:0005403)5.31939305
5Eczematoid dermatitis (HP:0000976)5.29310995
6Abnormality of T cell number (HP:0011839)5.04133432
7Autoimmune hemolytic anemia (HP:0001890)5.01412020
8Petechiae (HP:0000967)4.83177235
9Myositis (HP:0100614)4.67140694
10Epistaxis (HP:0000421)4.60140859
11Abnormal platelet volume (HP:0011876)4.40027186
12Increased IgM level (HP:0003496)4.28998483
13Purpura (HP:0000979)4.20470234
14Spontaneous hematomas (HP:0007420)4.18252482
15Abnormality of T cells (HP:0002843)4.17335636
16Gingival bleeding (HP:0000225)4.04226569
17Panhypogammaglobulinemia (HP:0003139)4.02625204
18Menorrhagia (HP:0000132)4.02331653
19Abnormal delayed hypersensitivity skin test (HP:0002963)4.00038748
20Optic neuritis (HP:0100653)3.96120880
21Retrobulbar optic neuritis (HP:0100654)3.96120880
22Increased mean platelet volume (HP:0011877)3.91135831
23Recurrent fungal infections (HP:0002841)3.87637853
24Encephalitis (HP:0002383)3.85821153
25Orchitis (HP:0100796)3.82598115
26Severe combined immunodeficiency (HP:0004430)3.79956605
27Recurrent abscess formation (HP:0002722)3.79530098
28Abnormality of macrophages (HP:0004311)3.75903716
29Recurrent bacterial skin infections (HP:0005406)3.74031787
30IgG deficiency (HP:0004315)3.73523222
31Meningitis (HP:0001287)3.45513508
32Vasculitis (HP:0002633)3.44014417
33Pustule (HP:0200039)3.36620471
34Joint swelling (HP:0001386)3.32166900
35Granulocytopenia (HP:0001913)3.31247632
36Obstructive lung disease (HP:0006536)3.27108999
37Chronic obstructive pulmonary disease (HP:0006510)3.27108999
38Leukocytosis (HP:0001974)3.19739373
39IgM deficiency (HP:0002850)3.17477390
40Abnormality of T cell physiology (HP:0011840)3.14276939
41Lymphopenia (HP:0001888)3.13461308
42Recurrent viral infections (HP:0004429)3.11814439
43Hyperlipoproteinemia (HP:0010980)3.10322203
44Increased IgE level (HP:0003212)3.07395408
45Eosinophilia (HP:0001880)3.06878552
46Abnormality of eosinophils (HP:0001879)3.06130988
47Chronic mucocutaneous candidiasis (HP:0002728)3.04216815
48Recurrent cutaneous fungal infections (HP:0011370)3.04216815
49Mediastinal lymphadenopathy (HP:0100721)3.02026529
50Recurrent bronchitis (HP:0002837)2.97109393
51Abnormality of cells of the lymphoid lineage (HP:0012140)2.95453595
52Gastrointestinal infarctions (HP:0005244)2.94582810
53Combined immunodeficiency (HP:0005387)2.92294796
54Keratoconjunctivitis sicca (HP:0001097)2.89565214
55Agammaglobulinemia (HP:0004432)2.80964942
56Pulmonary infiltrates (HP:0002113)2.78718127
57Recurrent skin infections (HP:0001581)2.77574152
58Keratoconjunctivitis (HP:0001096)2.75082227
59Hypochromic anemia (HP:0001931)2.73018791
60Abnormality of B cell number (HP:0010975)2.71947987
61Hypergammaglobulinemia (HP:0010702)2.71705381
62Chronic diarrhea (HP:0002028)2.70942542
63Inflammation of the large intestine (HP:0002037)2.68398972
64Chest pain (HP:0100749)2.67830512
65Gastrointestinal inflammation (HP:0004386)2.57050349
66Chronic otitis media (HP:0000389)2.53344141
67Pulmonary embolism (HP:0002204)2.51220724
68B lymphocytopenia (HP:0010976)2.47980942
69Impaired platelet aggregation (HP:0003540)2.41326126
70Abnormal platelet function (HP:0011869)2.41326126
71Hypochromic microcytic anemia (HP:0004840)2.39203051
72Arterial thrombosis (HP:0004420)2.35250058
73Microcytic anemia (HP:0001935)2.33203356
74Urticaria (HP:0001025)2.32480887
75Recurrent gram-negative bacterial infections (HP:0005420)2.31100753
76Hemoptysis (HP:0002105)2.30960408
77Papilloma (HP:0012740)2.27091320
78Verrucae (HP:0200043)2.27091320
79Anorexia (HP:0002039)2.26604310
80Lymphoma (HP:0002665)2.24540199
81Episodic fever (HP:0001954)2.23275957
82Abnormality of the prostate (HP:0008775)2.23128331
83Papilledema (HP:0001085)2.21500688
84Autoimmune thrombocytopenia (HP:0001973)2.18997344
85Acute hepatic failure (HP:0006554)2.14640152
86Gingivitis (HP:0000230)2.10527630
87Gangrene (HP:0100758)2.10041163
88Thyroiditis (HP:0100646)2.09282699
89Hypoproteinemia (HP:0003075)2.05248491
90Gastrointestinal stroma tumor (HP:0100723)2.03614809
91Abnormal pupillary function (HP:0007686)2.02730163
92Polyneuropathy (HP:0001271)2.00846264
93Hepatosplenomegaly (HP:0001433)1.98048966
94Colitis (HP:0002583)1.97920931
95Cellulitis (HP:0100658)1.96330917
96IgA deficiency (HP:0002720)1.93442122
97Abnormality of the heme biosynthetic pathway (HP:0010472)1.92895077
98Recurrent sinusitis (HP:0011108)1.92415537
99Arthralgia (HP:0002829)1.91963827
100Nasal polyposis (HP:0100582)1.91068908

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.36720855
2TXK4.33301015
3RIPK43.48306993
4FES3.30903179
5BTK2.91633310
6TAOK32.80539539
7ZAP702.77345136
8PRPF4B2.50831608
9ITK2.46791772
10GRK62.41414007
11CSK2.24826030
12SYK2.20092240
13TEC2.18059326
14MST42.15579742
15TYK22.07238652
16TNK21.98490032
17SIK31.95124958
18HCK1.94300640
19NLK1.88133470
20JAK31.86095181
21IKBKE1.85234362
22LCK1.82878658
23CSF1R1.58783467
24IRAK41.57708253
25JAK11.57366230
26PASK1.54091024
27PIK3CG1.52437110
28LYN1.50232192
29MAP3K131.42170301
30BLK1.42101741
31FGFR41.39506096
32TBK11.36176411
33MAP2K31.26972504
34CAMKK21.26405101
35EPHB11.21106867
36CAMKK11.15102153
37TYRO31.12437343
38IKBKB1.11879128
39BMX1.06563092
40MARK31.05778917
41RIPK11.04048358
42MAP3K141.02050982
43IRAK11.00091530
44MAP3K110.99375480
45JAK20.97794146
46PRKCQ0.96072895
47FGFR30.94910235
48PDK10.92986541
49TESK20.90412777
50MAPK110.90046863
51TAOK10.89440348
52FGR0.87253849
53MAP3K30.83388460
54PIM10.78786805
55KIT0.74775368
56TAOK20.74175116
57STK100.73877355
58EPHA30.71380581
59VRK10.69303936
60PDGFRB0.68504975
61FYN0.68292957
62MAP3K10.67500331
63MAPK120.66743955
64BMPR20.66109384
65HIPK20.64761581
66SCYL20.63415241
67LRRK20.62931442
68ERN10.57320539
69RET0.55284191
70SIK20.53513485
71PKN20.50975743
72PTK2B0.49237269
73MARK20.46152079
74CDK40.45556465
75IRAK30.45245834
76MAP3K50.44683767
77MAP2K60.44009477
78GRK50.41615969
79PDPK10.40244732
80MAPK70.38929090
81MAP3K100.36934305
82TGFBR20.36797700
83NEK60.35830002
84YES10.35281618
85MYLK0.33090787
86CLK10.30622301
87TLK10.30547177
88ADRBK20.29233965
89MAP3K70.29008486
90PIK3CA0.26398195
91MAPKAPK20.26353410
92PRKD10.25246290
93DYRK1B0.24624206
94IRAK20.24330378
95IGF1R0.24122501
96MAPK30.22547969
97INSR0.21131774
98TRIB30.20854654
99PRKD20.19535268
100KSR20.19184442

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.66902143
2T cell receptor signaling pathway_Homo sapiens_hsa046603.34379708
3Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.84689822
4Graft-versus-host disease_Homo sapiens_hsa053322.63743452
5Autoimmune thyroid disease_Homo sapiens_hsa053202.63464202
6Allograft rejection_Homo sapiens_hsa053302.62051262
7Hematopoietic cell lineage_Homo sapiens_hsa046402.52954501
8Measles_Homo sapiens_hsa051622.34335149
9Platelet activation_Homo sapiens_hsa046112.33869518
10Osteoclast differentiation_Homo sapiens_hsa043802.28924933
11B cell receptor signaling pathway_Homo sapiens_hsa046622.19678320
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.19177243
13NF-kappa B signaling pathway_Homo sapiens_hsa040641.94755083
14RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.80833921
15Chemokine signaling pathway_Homo sapiens_hsa040621.80830282
16Acute myeloid leukemia_Homo sapiens_hsa052211.78173504
17Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.75998866
18Antigen processing and presentation_Homo sapiens_hsa046121.73904367
19Type I diabetes mellitus_Homo sapiens_hsa049401.73181582
20Leishmaniasis_Homo sapiens_hsa051401.71603284
21Intestinal immune network for IgA production_Homo sapiens_hsa046721.66279795
22Toll-like receptor signaling pathway_Homo sapiens_hsa046201.62205371
23Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.61403591
24Viral myocarditis_Homo sapiens_hsa054161.61241340
25Jak-STAT signaling pathway_Homo sapiens_hsa046301.60815398
26SNARE interactions in vesicular transport_Homo sapiens_hsa041301.45756967
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.44107915
28Non-small cell lung cancer_Homo sapiens_hsa052231.38563200
29Staphylococcus aureus infection_Homo sapiens_hsa051501.38390802
30Herpes simplex infection_Homo sapiens_hsa051681.36275383
31Hepatitis B_Homo sapiens_hsa051611.35766703
32Malaria_Homo sapiens_hsa051441.35475222
33Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.34283305
34TNF signaling pathway_Homo sapiens_hsa046681.19294789
35Shigellosis_Homo sapiens_hsa051311.18788428
36Leukocyte transendothelial migration_Homo sapiens_hsa046701.18217414
37NOD-like receptor signaling pathway_Homo sapiens_hsa046211.16731870
38Tuberculosis_Homo sapiens_hsa051521.15098417
39Viral carcinogenesis_Homo sapiens_hsa052031.15041859
40Influenza A_Homo sapiens_hsa051641.14333950
41Pancreatic cancer_Homo sapiens_hsa052121.13913294
42Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.10736523
43Toxoplasmosis_Homo sapiens_hsa051451.08415629
44Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.07837236
45Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.04931951
46Asthma_Homo sapiens_hsa053101.04706204
47Phosphatidylinositol signaling system_Homo sapiens_hsa040700.96701747
48VEGF signaling pathway_Homo sapiens_hsa043700.94657151
49Apoptosis_Homo sapiens_hsa042100.89085293
50Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.86967339
51Colorectal cancer_Homo sapiens_hsa052100.86660220
52Hepatitis C_Homo sapiens_hsa051600.84404463
53Endocytosis_Homo sapiens_hsa041440.83115629
54Chronic myeloid leukemia_Homo sapiens_hsa052200.82819158
55Legionellosis_Homo sapiens_hsa051340.79057424
56HTLV-I infection_Homo sapiens_hsa051660.78219233
57Epstein-Barr virus infection_Homo sapiens_hsa051690.78037861
58Endometrial cancer_Homo sapiens_hsa052130.76881176
59African trypanosomiasis_Homo sapiens_hsa051430.75509715
60Choline metabolism in cancer_Homo sapiens_hsa052310.75426046
61Phospholipase D signaling pathway_Homo sapiens_hsa040720.70662682
62Sphingolipid signaling pathway_Homo sapiens_hsa040710.67053777
63Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.65736943
64Renal cell carcinoma_Homo sapiens_hsa052110.64272228
65Rheumatoid arthritis_Homo sapiens_hsa053230.63417790
66Prolactin signaling pathway_Homo sapiens_hsa049170.59538676
67FoxO signaling pathway_Homo sapiens_hsa040680.58958223
68Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.55918305
69Phagosome_Homo sapiens_hsa041450.54970693
70Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.54290316
71Glycerophospholipid metabolism_Homo sapiens_hsa005640.52468694
72Regulation of autophagy_Homo sapiens_hsa041400.51801748
73Salmonella infection_Homo sapiens_hsa051320.51603798
74AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.51299020
75Inositol phosphate metabolism_Homo sapiens_hsa005620.51269336
76Neurotrophin signaling pathway_Homo sapiens_hsa047220.50463528
77Pertussis_Homo sapiens_hsa051330.45345106
78MAPK signaling pathway_Homo sapiens_hsa040100.45092007
79Arachidonic acid metabolism_Homo sapiens_hsa005900.43585859
80Ras signaling pathway_Homo sapiens_hsa040140.42456465
81Thyroid cancer_Homo sapiens_hsa052160.41684479
82Regulation of actin cytoskeleton_Homo sapiens_hsa048100.40233721
83Carbohydrate digestion and absorption_Homo sapiens_hsa049730.39598752
84Prostate cancer_Homo sapiens_hsa052150.39266868
85alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.37075454
86Transcriptional misregulation in cancer_Homo sapiens_hsa052020.35712368
87Rap1 signaling pathway_Homo sapiens_hsa040150.35643370
88Vascular smooth muscle contraction_Homo sapiens_hsa042700.35456748
89Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.34085882
90Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.32125394
91Systemic lupus erythematosus_Homo sapiens_hsa053220.30971381
92Glioma_Homo sapiens_hsa052140.30370311
93Glycerolipid metabolism_Homo sapiens_hsa005610.28758050
94Insulin resistance_Homo sapiens_hsa049310.28307297
95Notch signaling pathway_Homo sapiens_hsa043300.27394845
96Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.26797269
97Dorso-ventral axis formation_Homo sapiens_hsa043200.25608037
98mTOR signaling pathway_Homo sapiens_hsa041500.23969942
99Long-term potentiation_Homo sapiens_hsa047200.22863518
100Adipocytokine signaling pathway_Homo sapiens_hsa049200.22135657

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