TRBV5-5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative T cell selection (GO:0043383)8.99527715
2negative thymic T cell selection (GO:0045060)8.62207977
3positive regulation of granulocyte differentiation (GO:0030854)7.49710235
4V(D)J recombination (GO:0033151)7.10865018
5positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)6.77157378
6thymic T cell selection (GO:0045061)6.67313002
7positive T cell selection (GO:0043368)6.45894530
8positive regulation of gamma-delta T cell activation (GO:0046645)6.30684238
9T cell selection (GO:0045058)6.21332723
10positive regulation of interleukin-2 biosynthetic process (GO:0045086)6.12895895
11regulation of B cell receptor signaling pathway (GO:0050855)6.10392190
12positive thymic T cell selection (GO:0045059)5.98826573
13T cell migration (GO:0072678)5.94420494
14regulation of gamma-delta T cell differentiation (GO:0045586)5.16172170
15cellular response to interleukin-4 (GO:0071353)4.96184219
16negative regulation of B cell mediated immunity (GO:0002713)4.71699466
17negative regulation of immunoglobulin mediated immune response (GO:0002890)4.71699466
18positive regulation of alpha-beta T cell proliferation (GO:0046641)4.67484930
19regulation of isotype switching to IgG isotypes (GO:0048302)4.55426568
20antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.51609849
21positive regulation of B cell differentiation (GO:0045579)4.51474710
22response to interleukin-4 (GO:0070670)4.48127362
23Peyers patch development (GO:0048541)4.46858539
24mucosal-associated lymphoid tissue development (GO:0048537)4.46858539
25regulation of granulocyte differentiation (GO:0030852)4.45301658
26regulation of gamma-delta T cell activation (GO:0046643)4.41684395
27regulation of interleukin-2 biosynthetic process (GO:0045076)4.39305713
28regulation of interleukin-4 production (GO:0032673)4.38068647
29regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.36459110
30antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.34131062
31mast cell activation (GO:0045576)4.30073167
32B cell proliferation (GO:0042100)4.20532140
33alpha-beta T cell differentiation (GO:0046632)4.20056111
34regulation of antigen receptor-mediated signaling pathway (GO:0050854)4.19664805
35antigen processing and presentation of endogenous antigen (GO:0019883)4.18191021
36leukocyte aggregation (GO:0070486)4.17506151
37regulation of alpha-beta T cell proliferation (GO:0046640)4.13643551
38negative regulation of cell killing (GO:0031342)3.98315693
39negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.98315693
40response to interleukin-15 (GO:0070672)3.98229599
41mast cell degranulation (GO:0043303)3.92422976
42mast cell activation involved in immune response (GO:0002279)3.92422976
43negative regulation of lymphocyte mediated immunity (GO:0002707)3.91586119
44T cell receptor signaling pathway (GO:0050852)3.89045430
45regulation of T cell tolerance induction (GO:0002664)3.86209393
46hypothalamus development (GO:0021854)3.83138341
47negative regulation of erythrocyte differentiation (GO:0045647)3.82724161
48alpha-beta T cell activation (GO:0046631)3.76979055
49diterpenoid biosynthetic process (GO:0016102)3.72972679
50positive regulation of tolerance induction (GO:0002645)3.68958865
51positive regulation of interleukin-4 production (GO:0032753)3.66233295
52regulation of B cell differentiation (GO:0045577)3.65690021
53positive regulation of calcium-mediated signaling (GO:0050850)3.63779632
54membrane raft organization (GO:0031579)3.63525190
55T cell differentiation (GO:0030217)3.61720801
56antigen receptor-mediated signaling pathway (GO:0050851)3.60163897
57cellular response to interleukin-15 (GO:0071350)3.55978885
58generation of neurons (GO:0048699)3.52515546
59positive regulation of natural killer cell mediated immunity (GO:0002717)3.51589662
60positive regulation of interleukin-2 production (GO:0032743)3.47475311
61negative regulation of T cell mediated immunity (GO:0002710)3.43591904
62regulation of T cell receptor signaling pathway (GO:0050856)3.42514059
63hepatocyte apoptotic process (GO:0097284)3.39768626
64antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.39213614
65tolerance induction (GO:0002507)3.38349433
66localization within membrane (GO:0051668)3.38219162
67negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.38204026
68positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.36452646
69positive regulation of macrophage differentiation (GO:0045651)3.35384344
70regulation of natural killer cell mediated immunity (GO:0002715)3.35238111
71regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.35238111
72lymphocyte costimulation (GO:0031294)3.32016875
73T cell costimulation (GO:0031295)3.30822173
74lymphocyte migration (GO:0072676)3.24733039
75retrograde transport, vesicle recycling within Golgi (GO:0000301)3.24696563
76activated T cell proliferation (GO:0050798)3.22173973
77protein targeting to Golgi (GO:0000042)3.18979924
78negative regulation of leukocyte mediated immunity (GO:0002704)3.18634595
79granulocyte differentiation (GO:0030851)3.17559706
80radial glial cell differentiation (GO:0060019)3.16868323
81positive regulation of alpha-beta T cell activation (GO:0046635)3.15282510
82regulation of histone H3-K27 methylation (GO:0061085)3.13877249
83regulation of tolerance induction (GO:0002643)3.13649349
84positive regulation of T cell differentiation in thymus (GO:0033089)3.13640518
85negative regulation of adaptive immune response (GO:0002820)3.11574860
86positive regulation of isotype switching (GO:0045830)3.06662679
87positive regulation by host of viral transcription (GO:0043923)3.05937513
88CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.03620711
89T-helper cell differentiation (GO:0042093)3.03620711
90regulation of interleukin-13 production (GO:0032656)3.03419272
91CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.02428416
92T cell activation (GO:0042110)3.01867286
93negative regulation of T cell apoptotic process (GO:0070233)2.98984171
94regulation of interleukin-5 production (GO:0032674)2.97989724
95somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.97923401
96somatic cell DNA recombination (GO:0016444)2.97923401
97regulation of defense response to virus by virus (GO:0050690)2.97804176
98establishment of protein localization to Golgi (GO:0072600)2.95323833
99cellular extravasation (GO:0045123)2.93971655
100negative regulation of thymocyte apoptotic process (GO:0070244)2.90582630

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_20620947_ChIP-Seq_CD4_POS_T_Human6.33901662
2RUNX_20019798_ChIP-Seq_JUKART_Human5.53389738
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.37497647
4E2F7_22180533_ChIP-Seq_HELA_Human4.29150156
5MYC_22102868_ChIP-Seq_BL_Human4.21869723
6UTX_26944678_Chip-Seq_JUKART_Human3.60886578
7MYB_26560356_Chip-Seq_TH2_Human3.56661851
8NOTCH1_21737748_ChIP-Seq_TLL_Human3.46561093
9GATA3_27048872_Chip-Seq_THYMUS_Human3.44212550
10ELF1_17652178_ChIP-ChIP_JURKAT_Human3.06589162
11FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.03456951
12KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.86551782
13IRF8_22096565_ChIP-ChIP_GC-B_Human2.79505882
14STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.77921419
15MYB_26560356_Chip-Seq_TH1_Human2.67457660
16MAF_26560356_Chip-Seq_TH1_Human2.60614593
17IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.58190442
18SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.57711214
19MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.55150558
20SCL_19346495_ChIP-Seq_HPC-7_Human2.50811903
21EGR1_19374776_ChIP-ChIP_THP-1_Human2.42131652
22E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.39115014
23MAF_26560356_Chip-Seq_TH2_Human2.24601009
24CIITA_25753668_ChIP-Seq_RAJI_Human2.20874690
25VDR_21846776_ChIP-Seq_THP-1_Human2.13972275
26TCF7_22412390_ChIP-Seq_EML_Mouse2.11041802
27VDR_24763502_ChIP-Seq_THP-1_Human2.04624979
28ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.04218869
29SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.00363643
30IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.98287041
31SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.98171461
32KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.97683537
33RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.96981843
34STAT4_19710469_ChIP-ChIP_TH1__Mouse1.91077650
35KDM2B_26808549_Chip-Seq_DND41_Human1.90345143
36TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.87471637
37VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.86735415
38RUNX1_22412390_ChIP-Seq_EML_Mouse1.79472813
39SPI1_23547873_ChIP-Seq_NB4_Human1.75388138
40HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.75175827
41RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.69603228
42MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.60790470
43FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.59525323
44MYB_21317192_ChIP-Seq_ERMYB_Mouse1.59073223
45KDM2B_26808549_Chip-Seq_SUP-B15_Human1.56888791
46GATA3_26560356_Chip-Seq_TH2_Human1.55406540
47EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.54660612
48SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.51497795
49NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.50806926
50SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.50304426
51KDM2B_26808549_Chip-Seq_JURKAT_Human1.47770245
52TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.45061804
53FOXP3_21729870_ChIP-Seq_TREG_Human1.41509291
54STAT6_21828071_ChIP-Seq_BEAS2B_Human1.39368555
55BRD4_27068464_Chip-Seq_AML-cells_Mouse1.39215759
56E2F4_17652178_ChIP-ChIP_JURKAT_Human1.36085611
57SPI1_23127762_ChIP-Seq_K562_Human1.34349458
58GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.29034057
59LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.28836229
60NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.28067748
61GATA2_22383799_ChIP-Seq_G1ME_Mouse1.19620446
62VDR_23849224_ChIP-Seq_CD4+_Human1.16315346
63IRF8_27001747_Chip-Seq_BMDM_Mouse1.13503839
64NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.13075574
65HOXB4_20404135_ChIP-ChIP_EML_Mouse1.09734558
66IRF8_21731497_ChIP-ChIP_J774_Mouse1.06717099
67CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.04570929
68GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.04153146
69TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02770228
70CTCF_21964334_ChIP-Seq_BJAB-B_Human1.01584144
71FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99393880
72PU_27001747_Chip-Seq_BMDM_Mouse0.97952532
73PU.1_20513432_ChIP-Seq_Bcells_Mouse0.97052117
74ERG_20887958_ChIP-Seq_HPC-7_Mouse0.94711198
75LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.94400853
76RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93749292
77PKCTHETA_26484144_Chip-Seq_BREAST_Human0.93602168
78CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92527494
79EGR1_19032775_ChIP-ChIP_M12_Human0.91000367
80GATA1_22383799_ChIP-Seq_G1ME_Mouse0.86686408
81TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.84607622
82GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84357686
83ELF1_20517297_ChIP-Seq_JURKAT_Human0.82438101
84GATA3_26560356_Chip-Seq_TH1_Human0.82409483
85CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.80407135
86YY1_21170310_ChIP-Seq_MESCs_Mouse0.80254074
87ELK3_25401928_ChIP-Seq_HUVEC_Human0.80149636
88E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.79884212
89GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.79494374
90BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.78508533
91MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.78268510
92CTCF_21964334_Chip-Seq_Bcells_Human0.76503178
93TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.75666508
94CTCF_27219007_Chip-Seq_ERYTHROID_Human0.74169798
95NCOR1_26117541_ChIP-Seq_K562_Human0.73781721
96ETS1_21867929_ChIP-Seq_TH2_Mouse0.72514697
97MYC_19079543_ChIP-ChIP_MESCs_Mouse0.71777137
98PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.70492093
99ETS1_22383799_ChIP-Seq_G1ME_Mouse0.69760348
100NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.69033260

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology6.87076047
2MP0000685_abnormal_immune_system4.20073974
3MP0005671_abnormal_response_to3.86690760
4MP0000703_abnormal_thymus_morphology3.37977417
5MP0002396_abnormal_hematopoietic_system3.30555509
6MP0004381_abnormal_hair_follicle3.20797192
7MP0009333_abnormal_splenocyte_physiolog2.99326297
8MP0001800_abnormal_humoral_immune2.93825651
9MP0005000_abnormal_immune_tolerance2.93264093
10MP0003183_abnormal_peptide_metabolism2.83650551
11MP0002398_abnormal_bone_marrow2.76076869
12MP0002405_respiratory_system_inflammati2.69732666
13MP0001835_abnormal_antigen_presentation2.62498426
14MP0002420_abnormal_adaptive_immunity2.57935253
15MP0001819_abnormal_immune_cell2.45565672
16MP0000716_abnormal_immune_system2.29214565
17MP0003436_decreased_susceptibility_to2.28693668
18MP0002722_abnormal_immune_system2.27139536
19MP0002723_abnormal_immune_serum2.25631501
20MP0002452_abnormal_antigen_presenting2.17353465
21MP0005075_abnormal_melanosome_morpholog2.15804604
22MP0001790_abnormal_immune_system2.15500767
23MP0005387_immune_system_phenotype2.15500767
24MP0002148_abnormal_hypersensitivity_rea2.14950171
25MP0008877_abnormal_DNA_methylation2.08307126
26MP0009278_abnormal_bone_marrow2.06978958
27MP0003300_gastrointestinal_ulcer2.05964348
28MP0008057_abnormal_DNA_replication1.99951202
29MP0000689_abnormal_spleen_morphology1.98691507
30MP0004947_skin_inflammation1.97743964
31MP0003724_increased_susceptibility_to1.86243580
32MP0002429_abnormal_blood_cell1.83701741
33MP0005025_abnormal_response_to1.83471569
34MP0002009_preneoplasia1.81432203
35MP0002163_abnormal_gland_morphology1.81081579
36MP0005464_abnormal_platelet_physiology1.66091245
37MP0004185_abnormal_adipocyte_glucose1.64696901
38MP0001873_stomach_inflammation1.61947937
39MP0009785_altered_susceptibility_to1.57636188
40MP0003866_abnormal_defecation1.55203464
41MP0005310_abnormal_salivary_gland1.54216039
42MP0002419_abnormal_innate_immunity1.50004981
43MP0010155_abnormal_intestine_physiology1.42700207
44MP0002166_altered_tumor_susceptibility1.42478536
45MP0000678_abnormal_parathyroid_gland1.31179133
46MP0001845_abnormal_inflammatory_respons1.29259698
47MP0000465_gastrointestinal_hemorrhage1.28913700
48MP0004808_abnormal_hematopoietic_stem1.16112406
49MP0005451_abnormal_body_composition1.12296677
50MP0003787_abnormal_imprinting1.01077066
51MP0004130_abnormal_muscle_cell1.00652539
52MP0000490_abnormal_crypts_of1.00402428
53MP0003303_peritoneal_inflammation0.98185352
54MP0002019_abnormal_tumor_incidence0.95957645
55MP0004019_abnormal_vitamin_homeostasis0.95407312
56MP0002877_abnormal_melanocyte_morpholog0.94451246
57MP0002006_tumorigenesis0.93801141
58MP0001919_abnormal_reproductive_system0.93055837
59MP0003959_abnormal_lean_body0.89519291
60MP0010094_abnormal_chromosome_stability0.89470225
61MP0008961_abnormal_basal_metabolism0.88095640
62MP0001853_heart_inflammation0.87308343
63MP0005666_abnormal_adipose_tissue0.84985906
64MP0008469_abnormal_protein_level0.83742655
65MP0008995_early_reproductive_senescence0.83406983
66MP0005166_decreased_susceptibility_to0.82901640
67MP0001348_abnormal_lacrimal_gland0.81986110
68MP0000858_altered_metastatic_potential0.81443132
69MP0002127_abnormal_cardiovascular_syste0.80090386
70MP0001545_abnormal_hematopoietic_system0.79820169
71MP0005397_hematopoietic_system_phenotyp0.79820169
72MP0005379_endocrine/exocrine_gland_phen0.78967878
73MP0002933_joint_inflammation0.78593233
74MP0002909_abnormal_adrenal_gland0.74443627
75MP0009763_increased_sensitivity_to0.72481927
76MP0006082_CNS_inflammation0.71743360
77MP0001986_abnormal_taste_sensitivity0.71345985
78MP0001730_embryonic_growth_arrest0.70702001
79MP0001851_eye_inflammation0.62421123
80MP0002138_abnormal_hepatobiliary_system0.60952901
81MP0001533_abnormal_skeleton_physiology0.60785584
82MP0000313_abnormal_cell_death0.60628605
83MP0004264_abnormal_extraembryonic_tissu0.57139180
84MP0008260_abnormal_autophagy0.55100951
85MP0000350_abnormal_cell_proliferation0.53760462
86MP0003111_abnormal_nucleus_morphology0.53470612
87MP0005645_abnormal_hypothalamus_physiol0.53048308
88MP0003172_abnormal_lysosome_physiology0.52387152
89MP0003045_fibrosis0.51204579
90MP0002693_abnormal_pancreas_physiology0.50489917
91MP0009697_abnormal_copulation0.49213900
92MP0009765_abnormal_xenobiotic_induced0.45319915
93MP0003786_premature_aging0.44408546
94MP0002970_abnormal_white_adipose0.44052150
95MP0003191_abnormal_cellular_cholesterol0.39874148
96MP0000920_abnormal_myelination0.38521764
97MP0003077_abnormal_cell_cycle0.37398228
98MP0001666_abnormal_nutrient_absorption0.37332901
99MP0001765_abnormal_ion_homeostasis0.36517145
100MP0005389_reproductive_system_phenotype0.36057359

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)6.47801937
2Severe combined immunodeficiency (HP:0004430)6.40335886
3Abnormality of T cell number (HP:0011839)6.13786131
4Chronic diarrhea (HP:0002028)5.97299628
5Autoimmune hemolytic anemia (HP:0001890)5.94261338
6Panhypogammaglobulinemia (HP:0003139)5.44374911
7Increased IgM level (HP:0003496)5.28533880
8Combined immunodeficiency (HP:0005387)5.21725407
9Lymphopenia (HP:0001888)4.73423627
10Abnormality of B cell number (HP:0010975)4.67383014
11Abnormality of cells of the lymphoid lineage (HP:0012140)4.59857931
12Abnormality of T cells (HP:0002843)4.57763491
13B lymphocytopenia (HP:0010976)4.50579225
14IgA deficiency (HP:0002720)4.39880901
15Abnormal delayed hypersensitivity skin test (HP:0002963)4.17983823
16Hypoplasia of the thymus (HP:0000778)4.08701520
17Gastrointestinal stroma tumor (HP:0100723)4.06525733
18Granulocytopenia (HP:0001913)4.04194906
19Elevated erythrocyte sedimentation rate (HP:0003565)3.97797902
20Recurrent viral infections (HP:0004429)3.93807085
21IgG deficiency (HP:0004315)3.80147270
22Recurrent fungal infections (HP:0002841)3.77770670
23Eosinophilia (HP:0001880)3.76541583
24Eczematoid dermatitis (HP:0000976)3.69558689
25Autoimmune thrombocytopenia (HP:0001973)3.64396080
26Thyroiditis (HP:0100646)3.64084283
27Lymphoma (HP:0002665)3.52826428
28Increased IgE level (HP:0003212)3.52336736
29Abnormality of eosinophils (HP:0001879)3.49080580
30Encephalitis (HP:0002383)3.47620691
31Stomatitis (HP:0010280)3.47166087
32Vasculitis (HP:0002633)3.39543448
33Aplasia/Hypoplasia of the thymus (HP:0010515)3.16909929
34Hypergammaglobulinemia (HP:0010702)3.09860547
35Prostate neoplasm (HP:0100787)3.02694198
36Meningitis (HP:0001287)3.01079147
37Leukocytosis (HP:0001974)2.93283144
38Spontaneous hematomas (HP:0007420)2.92810573
39Abnormality of T cell physiology (HP:0011840)2.83216483
40Abnormality of the fingertips (HP:0001211)2.79997630
41Agammaglobulinemia (HP:0004432)2.70195451
42Viral hepatitis (HP:0006562)2.70067721
43Abnormality of the prostate (HP:0008775)2.68460713
44Abnormality of the thymus (HP:0000777)2.67781247
45Pustule (HP:0200039)2.53744443
46Subacute progressive viral hepatitis (HP:0006572)2.51557365
47Acute hepatic failure (HP:0006554)2.50676841
48Papilloma (HP:0012740)2.50205452
49Verrucae (HP:0200043)2.50205452
50Chronic obstructive pulmonary disease (HP:0006510)2.49966681
51Obstructive lung disease (HP:0006536)2.49966681
52Prolonged bleeding time (HP:0003010)2.46094655
53Slow saccadic eye movements (HP:0000514)2.45818227
54Recurrent bronchitis (HP:0002837)2.44704509
55Myositis (HP:0100614)2.36083364
56Basal cell carcinoma (HP:0002671)2.35787879
57Abnormality of the columella (HP:0009929)2.32855335
58Recurrent cutaneous fungal infections (HP:0011370)2.29356641
59Chronic mucocutaneous candidiasis (HP:0002728)2.29356641
60Gastrointestinal inflammation (HP:0004386)2.27495132
61Abnormality of the left ventricular outflow tract (HP:0011103)2.26393797
62Subaortic stenosis (HP:0001682)2.26393797
63Seborrheic dermatitis (HP:0001051)2.24385540
64Aplastic anemia (HP:0001915)2.24179517
65IgM deficiency (HP:0002850)2.23757197
66Hepatitis (HP:0012115)2.21580990
67Joint swelling (HP:0001386)2.20680122
68Prominent nose (HP:0000448)2.19646422
69Emphysema (HP:0002097)2.11175920
70Pancytopenia (HP:0001876)2.09335760
71Epistaxis (HP:0000421)2.07245563
72Inflammation of the large intestine (HP:0002037)2.05969752
73Broad face (HP:0000283)2.04498467
74Trigonocephaly (HP:0000243)2.03447998
75Fatigue (HP:0012378)1.99841474
76Hypochromic anemia (HP:0001931)1.99568057
77Dysmetric saccades (HP:0000641)1.99562427
78Papilledema (HP:0001085)1.97053485
79High anterior hairline (HP:0009890)1.95261511
80Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.94289038
81Abnormality of male internal genitalia (HP:0000022)1.87526601
82Chest pain (HP:0100749)1.82645756
83Cutis marmorata (HP:0000965)1.80814393
84Amaurosis fugax (HP:0100576)1.79886159
85Micronodular cirrhosis (HP:0001413)1.79506566
86Somatic mutation (HP:0001428)1.79364109
87Bicuspid aortic valve (HP:0001647)1.77428723
88Menstrual irregularities (HP:0000858)1.75361585
89Abnormality of macrophages (HP:0004311)1.75186342
90Mediastinal lymphadenopathy (HP:0100721)1.74482435
91Recurrent abscess formation (HP:0002722)1.74437249
92Restrictive lung disease (HP:0002091)1.74342490
93Pulmonary embolism (HP:0002204)1.73082106
94Neoplasm of the adrenal cortex (HP:0100641)1.71478196
95Stomach cancer (HP:0012126)1.70949396
96Leukopenia (HP:0001882)1.69318008
97Optic nerve coloboma (HP:0000588)1.69253470
98Easy fatigability (HP:0003388)1.67359733
99Gastrointestinal infarctions (HP:0005244)1.67274153
100Deep palmar crease (HP:0006191)1.66841286

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EEF2K4.82154980
2PRPF4B4.22766733
3MAP4K13.96358927
4SCYL23.61806731
5NLK3.32585777
6TXK3.05196676
7ITK2.56419853
8MAP3K102.42770920
9CAMKK12.40682031
10GRK62.31636759
11ZAP702.25865103
12CAMKK22.02943429
13PASK2.01473286
14FES1.93681561
15TRIB31.89179887
16MAP3K71.83463692
17SYK1.81558983
18CDK121.76187443
19TYK21.70499462
20BTK1.67896582
21TAOK31.65179151
22PIK3CG1.64132682
23MAPK111.59652482
24SMG11.59495111
25FGFR21.58384610
26MARK21.51727660
27MAP3K131.51671995
28RIPK41.38592741
29LCK1.38590803
30TEC1.30498192
31CSK1.25180865
32PRKCQ1.21037992
33CDK41.12406004
34HCK1.10852566
35MAPK121.07041470
36CDK61.05423193
37FGFR31.04678890
38TYRO31.04282445
39FGFR41.04175663
40SIK31.00155622
41PKN21.00005199
42LYN0.98583367
43CSF1R0.97660549
44TNK20.97142711
45PRKD30.93969939
46IRAK40.91724227
47CDK90.90463647
48MAP3K140.87549160
49HIPK20.87045700
50TBK10.84473090
51IKBKE0.84152081
52NTRK20.82312122
53LRRK20.82297719
54PDK10.78305596
55JAK30.76922871
56MAPK40.76538329
57VRK20.73705872
58MST40.71909704
59TAF10.69022942
60TESK20.67905894
61CAMK10.65120823
62FGR0.64860331
63ICK0.63776585
64BRD40.62949575
65TRPM70.62403768
66CLK10.60816956
67CDK70.59138326
68JAK10.57290535
69MAPKAPK50.54446194
70MAPK70.53103869
71PRKCH0.51631089
72CAMK40.49592400
73BLK0.48940941
74TAOK20.47678714
75MAP2K30.47082474
76SIK10.46720442
77IRAK10.44559099
78IKBKB0.43129959
79MAP3K110.42789740
80STK100.42477688
81PDGFRB0.41314188
82CDK80.39878042
83FYN0.39678056
84MARK30.39657279
85KDR0.38077394
86NEK60.37537751
87RET0.36322152
88MAP3K30.35447149
89ATR0.33378109
90MAP2K20.32862074
91EIF2AK20.32343511
92RPS6KB20.31899067
93MAPK30.31267043
94SRPK10.30652907
95MAP3K10.30546647
96SIK20.30103872
97MAPKAPK20.25154118
98PTK60.22943867
99MAPK130.21716482
100NEK90.20965290

Predicted pathways (KEGG)

RankGene SetZ-score
1Hematopoietic cell lineage_Homo sapiens_hsa046405.86809299
2Primary immunodeficiency_Homo sapiens_hsa053405.45985827
3T cell receptor signaling pathway_Homo sapiens_hsa046603.88607091
4Acute myeloid leukemia_Homo sapiens_hsa052212.69529895
5Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.53198268
6B cell receptor signaling pathway_Homo sapiens_hsa046622.47129811
7Thyroid cancer_Homo sapiens_hsa052162.38047686
8Measles_Homo sapiens_hsa051622.37129688
9Non-small cell lung cancer_Homo sapiens_hsa052232.09951139
10Endometrial cancer_Homo sapiens_hsa052131.91634188
11Autoimmune thyroid disease_Homo sapiens_hsa053201.76575830
12Colorectal cancer_Homo sapiens_hsa052101.74589912
13Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.67370008
14Allograft rejection_Homo sapiens_hsa053301.65730924
15Notch signaling pathway_Homo sapiens_hsa043301.56477556
16Ribosome_Homo sapiens_hsa030101.55347353
17NF-kappa B signaling pathway_Homo sapiens_hsa040641.53399296
18Chronic myeloid leukemia_Homo sapiens_hsa052201.50985745
19DNA replication_Homo sapiens_hsa030301.42033497
20Graft-versus-host disease_Homo sapiens_hsa053321.38396877
21Prostate cancer_Homo sapiens_hsa052151.35702763
22Leishmaniasis_Homo sapiens_hsa051401.31747436
23Hepatitis B_Homo sapiens_hsa051611.31689156
24Intestinal immune network for IgA production_Homo sapiens_hsa046721.30148977
25Pancreatic cancer_Homo sapiens_hsa052121.27183261
26RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.22536078
27Herpes simplex infection_Homo sapiens_hsa051681.17099719
28Phosphatidylinositol signaling system_Homo sapiens_hsa040701.13848063
29Chemokine signaling pathway_Homo sapiens_hsa040621.11747720
30Inositol phosphate metabolism_Homo sapiens_hsa005621.09370848
31Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.07748910
32Jak-STAT signaling pathway_Homo sapiens_hsa046301.07429605
33Osteoclast differentiation_Homo sapiens_hsa043801.07260671
34Glioma_Homo sapiens_hsa052141.06765341
35Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.06736341
36Dorso-ventral axis formation_Homo sapiens_hsa043201.06446888
37Platelet activation_Homo sapiens_hsa046111.06145934
38Antigen processing and presentation_Homo sapiens_hsa046121.01743241
39Spliceosome_Homo sapiens_hsa030401.01587420
40Cell cycle_Homo sapiens_hsa041101.00628471
41Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.99754170
42Malaria_Homo sapiens_hsa051440.98789807
43Epstein-Barr virus infection_Homo sapiens_hsa051690.96299816
44HTLV-I infection_Homo sapiens_hsa051660.93018861
45Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.91018820
46Legionellosis_Homo sapiens_hsa051340.90698167
47Type I diabetes mellitus_Homo sapiens_hsa049400.89927464
48Viral myocarditis_Homo sapiens_hsa054160.88746600
49Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.85798314
50VEGF signaling pathway_Homo sapiens_hsa043700.85560058
51mRNA surveillance pathway_Homo sapiens_hsa030150.85481069
52Viral carcinogenesis_Homo sapiens_hsa052030.85258730
53Toll-like receptor signaling pathway_Homo sapiens_hsa046200.83989540
54Leukocyte transendothelial migration_Homo sapiens_hsa046700.82932051
55African trypanosomiasis_Homo sapiens_hsa051430.74772012
56Apoptosis_Homo sapiens_hsa042100.71223067
57Carbohydrate digestion and absorption_Homo sapiens_hsa049730.66826100
58mTOR signaling pathway_Homo sapiens_hsa041500.66687912
59Thyroid hormone signaling pathway_Homo sapiens_hsa049190.66036256
60Influenza A_Homo sapiens_hsa051640.64727046
61Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.63296596
62Long-term potentiation_Homo sapiens_hsa047200.62709430
63Nucleotide excision repair_Homo sapiens_hsa034200.62289235
64Renal cell carcinoma_Homo sapiens_hsa052110.55567885
65Sphingolipid signaling pathway_Homo sapiens_hsa040710.54862801
66Choline metabolism in cancer_Homo sapiens_hsa052310.54458595
67TNF signaling pathway_Homo sapiens_hsa046680.53492504
68Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.52952251
69Adherens junction_Homo sapiens_hsa045200.51122450
70Neurotrophin signaling pathway_Homo sapiens_hsa047220.50998776
71Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.50901125
72Non-homologous end-joining_Homo sapiens_hsa034500.49292042
73NOD-like receptor signaling pathway_Homo sapiens_hsa046210.48303516
74Base excision repair_Homo sapiens_hsa034100.45424223
75Shigellosis_Homo sapiens_hsa051310.44799461
76Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.44265856
77Tuberculosis_Homo sapiens_hsa051520.42926635
78Wnt signaling pathway_Homo sapiens_hsa043100.42291506
79Basal cell carcinoma_Homo sapiens_hsa052170.41949604
80Phospholipase D signaling pathway_Homo sapiens_hsa040720.41044604
81Prolactin signaling pathway_Homo sapiens_hsa049170.39826176
82FoxO signaling pathway_Homo sapiens_hsa040680.39669808
83MicroRNAs in cancer_Homo sapiens_hsa052060.37246531
84Hepatitis C_Homo sapiens_hsa051600.35984385
85Ras signaling pathway_Homo sapiens_hsa040140.35352769
86Homologous recombination_Homo sapiens_hsa034400.34932798
87ErbB signaling pathway_Homo sapiens_hsa040120.34845161
88Toxoplasmosis_Homo sapiens_hsa051450.33852417
89RNA transport_Homo sapiens_hsa030130.33555137
90AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.32810888
91Mismatch repair_Homo sapiens_hsa034300.32611437
92Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.31455800
93SNARE interactions in vesicular transport_Homo sapiens_hsa041300.30083001
94Oxytocin signaling pathway_Homo sapiens_hsa049210.30071339
95Lysine degradation_Homo sapiens_hsa003100.29392914
96Small cell lung cancer_Homo sapiens_hsa052220.28865891
97Melanoma_Homo sapiens_hsa052180.28835975
98Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.28720506
99Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.27384000
100Melanogenesis_Homo sapiens_hsa049160.25038841

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