TRBV5-8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)8.51426963
2Arp2/3 complex-mediated actin nucleation (GO:0034314)7.84451728
3actin nucleation (GO:0045010)6.54286433
4regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450916.41708832
5T cell migration (GO:0072678)6.24168186
6negative T cell selection (GO:0043383)6.10912820
7gonadal mesoderm development (GO:0007506)5.75516076
8positive regulation of gamma-delta T cell activation (GO:0046645)5.53769292
9positive regulation of natural killer cell mediated immunity (GO:0002717)5.53241963
10regulation of B cell receptor signaling pathway (GO:0050855)5.48016030
11positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)5.44043434
12antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.41220560
13regulation of natural killer cell mediated cytotoxicity (GO:0042269)5.35588042
14regulation of natural killer cell mediated immunity (GO:0002715)5.35588042
15antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.35179319
16negative thymic T cell selection (GO:0045060)5.28247740
17antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.22509848
18cytidine metabolic process (GO:0046087)5.21959757
19cytidine catabolic process (GO:0006216)5.21959757
20cytidine deamination (GO:0009972)5.21959757
21positive T cell selection (GO:0043368)5.06286124
22sequestering of actin monomers (GO:0042989)5.02525074
23negative regulation of cell killing (GO:0031342)4.91599584
24negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.91599584
25antigen processing and presentation of endogenous antigen (GO:0019883)4.83092748
26purine deoxyribonucleotide catabolic process (GO:0009155)4.78110282
27negative regulation of stress fiber assembly (GO:0051497)4.70405815
28positive regulation of lamellipodium assembly (GO:0010592)4.65621700
29pyrimidine ribonucleoside catabolic process (GO:0046133)4.63918692
30T cell selection (GO:0045058)4.57097758
31regulation of gamma-delta T cell differentiation (GO:0045586)4.56244469
32positive thymic T cell selection (GO:0045059)4.50258025
33DNA deamination (GO:0045006)4.40101662
34tolerance induction (GO:0002507)4.38647195
35thymic T cell selection (GO:0045061)4.34708395
36cellular response to interleukin-15 (GO:0071350)4.34636524
37positive regulation of leukocyte mediated cytotoxicity (GO:0001912)4.32951382
38positive regulation of calcium-mediated signaling (GO:0050850)4.31071811
39leukocyte aggregation (GO:0070486)4.25138755
40regulation of defense response to virus by virus (GO:0050690)4.24430731
41regulation of alpha-beta T cell proliferation (GO:0046640)4.16369815
42regulation of antigen receptor-mediated signaling pathway (GO:0050854)4.06053717
43positive regulation of alpha-beta T cell proliferation (GO:0046641)4.05930241
44regulation of gamma-delta T cell activation (GO:0046643)3.99500683
45negative regulation of execution phase of apoptosis (GO:1900118)3.98171414
46response to interleukin-15 (GO:0070672)3.96949395
47negative regulation of phagocytosis (GO:0050765)3.96483043
48regulation of leukocyte mediated cytotoxicity (GO:0001910)3.95350187
49regulation of isotype switching to IgG isotypes (GO:0048302)3.90257935
50T cell receptor signaling pathway (GO:0050852)3.89715562
51activated T cell proliferation (GO:0050798)3.89294119
52cytolysis (GO:0019835)3.87479378
53regulation of T cell receptor signaling pathway (GO:0050856)3.84682148
54positive regulation of cell killing (GO:0031343)3.78743425
55negative regulation of T cell apoptotic process (GO:0070233)3.75284086
56lymphocyte chemotaxis (GO:0048247)3.70558082
57regulation of T cell tolerance induction (GO:0002664)3.66536157
58lymphocyte migration (GO:0072676)3.64685021
59chemokine-mediated signaling pathway (GO:0070098)3.62701993
60antigen receptor-mediated signaling pathway (GO:0050851)3.55340636
61respiratory burst (GO:0045730)3.55122841
62cellular defense response (GO:0006968)3.49121957
63regulation of cell killing (GO:0031341)3.44052641
64positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.42851080
65T cell costimulation (GO:0031295)3.42844194
66positive regulation of lamellipodium organization (GO:1902745)3.42429461
67lymphocyte costimulation (GO:0031294)3.38711705
68mature B cell differentiation involved in immune response (GO:0002313)3.34467185
69positive regulation of translational initiation (GO:0045948)3.33265314
70negative regulation of actin filament bundle assembly (GO:0032232)3.28744094
71execution phase of apoptosis (GO:0097194)3.28144470
72Peyers patch development (GO:0048541)3.25714864
73mucosal-associated lymphoid tissue development (GO:0048537)3.25714864
74positive regulation of B cell differentiation (GO:0045579)3.23520290
75positive regulation of tolerance induction (GO:0002645)3.18903789
76regulation of regulatory T cell differentiation (GO:0045589)3.18879419
77positive regulation of T cell mediated cytotoxicity (GO:0001916)3.11689498
78positive regulation of monocyte chemotaxis (GO:0090026)3.09575978
79T cell mediated immunity (GO:0002456)3.08787800
80B cell receptor signaling pathway (GO:0050853)3.08546036
81regulation of tolerance induction (GO:0002643)3.07311539
82positive regulation of T cell differentiation in thymus (GO:0033089)3.06066976
83regulation of B cell differentiation (GO:0045577)3.05027789
84negative regulation of leukocyte mediated immunity (GO:0002704)3.02403321
85regulation of calcium-mediated signaling (GO:0050848)3.02007090
86T cell differentiation (GO:0030217)2.97996633
87positive regulation of lymphocyte mediated immunity (GO:0002708)2.97042599
88antigen processing and presentation via MHC class Ib (GO:0002475)2.97039791
89positive regulation of actin filament polymerization (GO:0030838)2.96878086
90activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.95113954
91regulation of T cell chemotaxis (GO:0010819)2.92341771
92positive regulation of T cell chemotaxis (GO:0010820)2.92341771
93regulation of T cell mediated cytotoxicity (GO:0001914)2.87458730
94negative regulation of telomere maintenance (GO:0032205)2.86177810
95regulation of activation of Janus kinase activity (GO:0010533)2.85181901
96natural killer cell differentiation (GO:0001779)2.84870565
97negative regulation of type 2 immune response (GO:0002829)2.84045204
98negative regulation of viral genome replication (GO:0045071)2.82215652
99dendritic cell chemotaxis (GO:0002407)2.81117430
100T cell activation (GO:0042110)2.80750206

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.84070717
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.47696154
3IRF8_22096565_ChIP-ChIP_GC-B_Human5.24187504
4ELF1_17652178_ChIP-ChIP_JURKAT_Human5.21356615
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.28169275
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.57125000
7RUNX_20019798_ChIP-Seq_JUKART_Human3.52913719
8MYB_26560356_Chip-Seq_TH2_Human3.52320505
9SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.49973545
10IRF8_21731497_ChIP-ChIP_J774_Mouse3.49720662
11BP1_19119308_ChIP-ChIP_Hs578T_Human3.37531662
12STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.10590588
13UTX_26944678_Chip-Seq_JUKART_Human2.87330070
14SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.69256518
15STAT4_19710469_ChIP-ChIP_TH1__Mouse2.57343910
16GATA3_27048872_Chip-Seq_THYMUS_Human2.57196837
17FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.56153727
18MYB_26560356_Chip-Seq_TH1_Human2.49819383
19RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.45886034
20MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.43113138
21MAF_26560356_Chip-Seq_TH1_Human2.39635439
22FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.24951470
23SPI1_23547873_ChIP-Seq_NB4_Human2.13850666
24GATA3_26560356_Chip-Seq_TH2_Human2.04191066
25HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.02678141
26SMAD_19615063_ChIP-ChIP_OVARY_Human1.97391402
27FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.96666456
28MAF_26560356_Chip-Seq_TH2_Human1.93743824
29SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.78067665
30SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.75510630
31CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.75277033
32IRF8_27001747_Chip-Seq_BMDM_Mouse1.74344561
33NOTCH1_21737748_ChIP-Seq_TLL_Human1.72242378
34BRD4_27068464_Chip-Seq_AML-cells_Mouse1.60538944
35RUNX1_22412390_ChIP-Seq_EML_Mouse1.57691750
36EST1_17652178_ChIP-ChIP_JURKAT_Human1.56069037
37E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.55294128
38GABP_17652178_ChIP-ChIP_JURKAT_Human1.54611395
39SPI1_23127762_ChIP-Seq_K562_Human1.52770372
40VDR_23849224_ChIP-Seq_CD4+_Human1.51376596
41TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.45735893
42EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.44178622
43RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.43697584
44NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.42558561
45MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.42171143
46FOXP3_21729870_ChIP-Seq_TREG_Human1.41293184
47CIITA_25753668_ChIP-Seq_RAJI_Human1.40512732
48LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.34077759
49NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.32352732
50VDR_24763502_ChIP-Seq_THP-1_Human1.31733099
51LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.30722190
52RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.30137304
53MYC_22102868_ChIP-Seq_BL_Human1.24081007
54GATA2_22383799_ChIP-Seq_G1ME_Mouse1.20908882
55RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.18004431
56E2F7_22180533_ChIP-Seq_HELA_Human1.16526624
57YY1_21170310_ChIP-Seq_MESCs_Mouse1.15699909
58GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.15437397
59BCL6_27268052_Chip-Seq_Bcells_Human1.12741309
60SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.09820863
61TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.08399862
62MYB_21317192_ChIP-Seq_ERMYB_Mouse1.07310848
63BCOR_27268052_Chip-Seq_Bcells_Human1.04248986
64RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.03656920
65TP63_17297297_ChIP-ChIP_HaCaT_Human1.03481631
66ELF1_20517297_ChIP-Seq_JURKAT_Human1.01149242
67VDR_21846776_ChIP-Seq_THP-1_Human1.00251670
68EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.00063254
69FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98779712
70CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.98188932
71CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.98111864
72CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.95379116
73GATA3_26560356_Chip-Seq_TH1_Human0.92574239
74CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.90119215
75P300_27268052_Chip-Seq_Bcells_Human0.89402643
76TCF7_22412390_ChIP-Seq_EML_Mouse0.88732089
77ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.88575422
78HOXB4_20404135_ChIP-ChIP_EML_Mouse0.87873513
79CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.87637727
80TDRD3_21172665_ChIP-Seq_MCF-7_Human0.85205336
81VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.85064692
82TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.83811934
83SPI1_20517297_ChIP-Seq_HL60_Human0.82089499
84NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.80257815
85THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.80156271
86E2F1_20622854_ChIP-Seq_HELA_Human0.78954171
87CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.78393198
88CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.77446440
89PHF8_20622854_ChIP-Seq_HELA_Human0.76982840
90NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.76669938
91RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.76240009
92SRF_21415370_ChIP-Seq_HL-1_Mouse0.75960773
93YY1_22570637_ChIP-Seq_MALME-3M_Human0.75324003
94SCL_19346495_ChIP-Seq_HPC-7_Human0.75320311
95SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.74743961
96PCGF2_27294783_Chip-Seq_NPCs_Mouse0.74682881
97SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.74188706
98GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.70954948
99ERG_20517297_ChIP-Seq_VCAP_Human0.70322917
100FLI1_21867929_ChIP-Seq_CD8_Mouse0.69896796

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to6.24503360
2MP0009785_altered_susceptibility_to4.31920565
3MP0003763_abnormal_thymus_physiology4.21007026
4MP0002166_altered_tumor_susceptibility3.65313892
5MP0001835_abnormal_antigen_presentation3.48368953
6MP0001800_abnormal_humoral_immune3.02529002
7MP0005025_abnormal_response_to3.01106522
8MP0001790_abnormal_immune_system2.93953489
9MP0005387_immune_system_phenotype2.93953489
10MP0000685_abnormal_immune_system2.90801410
11MP0009333_abnormal_splenocyte_physiolog2.85314532
12MP0005000_abnormal_immune_tolerance2.82755646
13MP0002420_abnormal_adaptive_immunity2.74448285
14MP0001819_abnormal_immune_cell2.65430779
15MP0003724_increased_susceptibility_to2.56188105
16MP0002723_abnormal_immune_serum2.53664132
17MP0002006_tumorigenesis2.52485572
18MP0003436_decreased_susceptibility_to2.50894261
19MP0004147_increased_porphyrin_level2.50303665
20MP0002148_abnormal_hypersensitivity_rea2.41120414
21MP0003866_abnormal_defecation2.40558397
22MP0002452_abnormal_antigen_presenting2.38150782
23MP0002398_abnormal_bone_marrow2.24537513
24MP0003045_fibrosis2.17582486
25MP0000703_abnormal_thymus_morphology2.14910963
26MP0002405_respiratory_system_inflammati2.14452196
27MP0002419_abnormal_innate_immunity2.06842798
28MP0006082_CNS_inflammation2.05582020
29MP0003448_altered_tumor_morphology1.98945662
30MP0000716_abnormal_immune_system1.97954473
31MP0002009_preneoplasia1.92524393
32MP0000689_abnormal_spleen_morphology1.84898070
33MP0002722_abnormal_immune_system1.84206898
34MP0001845_abnormal_inflammatory_respons1.77532707
35MP0004947_skin_inflammation1.74025936
36MP0010155_abnormal_intestine_physiology1.72201946
37MP0002933_joint_inflammation1.68419583
38MP0001542_abnormal_bone_strength1.59219801
39MP0002429_abnormal_blood_cell1.58451507
40MP0008469_abnormal_protein_level1.52448533
41MP0002132_abnormal_respiratory_system1.32792281
42MP0005166_decreased_susceptibility_to1.32183979
43MP0005464_abnormal_platelet_physiology1.24499236
44MP0009763_increased_sensitivity_to1.21912827
45MP0001533_abnormal_skeleton_physiology1.21389450
46MP0000858_altered_metastatic_potential1.19842096
47MP0003011_delayed_dark_adaptation1.19248881
48MP0000604_amyloidosis1.14226916
49MP0003329_amyloid_beta_deposits1.09990670
50MP0001873_stomach_inflammation1.08332352
51MP0003300_gastrointestinal_ulcer1.07771061
52MP0003303_peritoneal_inflammation1.04079362
53MP0002693_abnormal_pancreas_physiology1.02536268
54MP0003806_abnormal_nucleotide_metabolis0.98003510
55MP0002138_abnormal_hepatobiliary_system0.97790822
56MP0009764_decreased_sensitivity_to0.96135468
57MP0004145_abnormal_muscle_electrophysio0.94651519
58MP0004883_abnormal_blood_vessel0.93029177
59MP0010386_abnormal_urinary_bladder0.89367680
60MP0004381_abnormal_hair_follicle0.88667296
61MP0000490_abnormal_crypts_of0.85513765
62MP0001853_heart_inflammation0.83582851
63MP0002998_abnormal_bone_remodeling0.82270586
64MP0000465_gastrointestinal_hemorrhage0.82120130
65MP0003656_abnormal_erythrocyte_physiolo0.81960231
66MP0003252_abnormal_bile_duct0.79852264
67MP0002277_abnormal_respiratory_mucosa0.77777116
68MP0002837_dystrophic_cardiac_calcinosis0.77690972
69MP0004130_abnormal_muscle_cell0.76937749
70MP0004142_abnormal_muscle_tone0.76666063
71MP0001919_abnormal_reproductive_system0.76208016
72MP0002168_other_aberrant_phenotype0.69611789
73MP0009643_abnormal_urine_homeostasis0.68136967
74MP0002019_abnormal_tumor_incidence0.68047845
75MP0005058_abnormal_lysosome_morphology0.67838603
76MP0001968_abnormal_touch/_nociception0.67012133
77MP0003137_abnormal_impulse_conducting0.65647370
78MP0000678_abnormal_parathyroid_gland0.65537763
79MP0008260_abnormal_autophagy0.64222694
80MP0005075_abnormal_melanosome_morpholog0.63908568
81MP0002139_abnormal_hepatobiliary_system0.62607264
82MP0005319_abnormal_enzyme/_coenzyme0.62595462
83MP0001851_eye_inflammation0.62106734
84MP0008961_abnormal_basal_metabolism0.61956151
85MP0005310_abnormal_salivary_gland0.59129059
86MP0002736_abnormal_nociception_after0.57814763
87MP0005636_abnormal_mineral_homeostasis0.54745678
88MP0003878_abnormal_ear_physiology0.52714058
89MP0005377_hearing/vestibular/ear_phenot0.52714058
90MP0001243_abnormal_dermal_layer0.52450139
91MP0002136_abnormal_kidney_physiology0.50550930
92MP0008873_increased_physiological_sensi0.48655848
93MP0005164_abnormal_response_to0.47940236
94MP0005266_abnormal_metabolism0.47730200
95MP0003690_abnormal_glial_cell0.47116384
96MP0003795_abnormal_bone_structure0.46589662
97MP0005645_abnormal_hypothalamus_physiol0.45060732
98MP0008874_decreased_physiological_sensi0.44402313
99MP0009697_abnormal_copulation0.43984176
100MP0003191_abnormal_cellular_cholesterol0.43915831

Predicted human phenotypes

RankGene SetZ-score
1Increased IgM level (HP:0003496)6.98381510
2Aplastic anemia (HP:0001915)6.27250586
3T lymphocytopenia (HP:0005403)5.99323464
4IgG deficiency (HP:0004315)5.52435265
5Acute hepatic failure (HP:0006554)5.29689874
6Spontaneous hematomas (HP:0007420)5.28485850
7Abnormality of T cell number (HP:0011839)5.26069586
8Elevated erythrocyte sedimentation rate (HP:0003565)5.00630416
9Severe combined immunodeficiency (HP:0004430)4.68220760
10Autoimmune hemolytic anemia (HP:0001890)4.58281846
11Encephalitis (HP:0002383)4.49728041
12Chronic diarrhea (HP:0002028)4.37858701
13Stomatitis (HP:0010280)4.04516089
14Abnormality of T cells (HP:0002843)4.00410604
15Broad face (HP:0000283)3.92566770
16Hypergammaglobulinemia (HP:0010702)3.91358529
17B lymphocytopenia (HP:0010976)3.85364491
18Combined immunodeficiency (HP:0005387)3.62781631
19Abnormality of B cell number (HP:0010975)3.56332602
20Abnormality of macrophages (HP:0004311)3.53295468
21IgM deficiency (HP:0002850)3.47415476
22Pancytopenia (HP:0001876)3.43593321
23Meningitis (HP:0001287)3.43362439
24Myositis (HP:0100614)3.38957429
25Recurrent viral infections (HP:0004429)3.33231659
26Increased IgE level (HP:0003212)3.32647718
27Thyroiditis (HP:0100646)3.32436630
283-Methylglutaconic aciduria (HP:0003535)3.28729641
29Lymphoma (HP:0002665)3.23556495
30Cellular immunodeficiency (HP:0005374)3.23382246
31Eczematoid dermatitis (HP:0000976)3.08586771
32Pustule (HP:0200039)3.06090069
33Recurrent bronchitis (HP:0002837)3.05846888
34Lymphopenia (HP:0001888)3.04828936
35Microcytic anemia (HP:0001935)2.99811263
36Hypoproteinemia (HP:0003075)2.98309951
37Eosinophilia (HP:0001880)2.89649313
38Recurrent fungal infections (HP:0002841)2.89367914
39Abnormality of eosinophils (HP:0001879)2.86605229
40Recurrent abscess formation (HP:0002722)2.85818343
41Petechiae (HP:0000967)2.76303893
42Obstructive lung disease (HP:0006536)2.71729520
43Chronic obstructive pulmonary disease (HP:0006510)2.71729520
44Abnormality of cells of the lymphoid lineage (HP:0012140)2.70832808
45Cerebral palsy (HP:0100021)2.69553616
46Oral leukoplakia (HP:0002745)2.69106309
47Cerebral hypomyelination (HP:0006808)2.65891425
48Gastrointestinal infarctions (HP:0005244)2.64937306
49Autoimmune thrombocytopenia (HP:0001973)2.59656018
50Recurrent bacterial skin infections (HP:0005406)2.58975885
51Symptomatic seizures (HP:0011145)2.58308840
52Leukocytosis (HP:0001974)2.54613266
53Granulocytopenia (HP:0001913)2.50162226
54Abnormality of the heme biosynthetic pathway (HP:0010472)2.47042232
55Tetany (HP:0001281)2.44327180
56Panhypogammaglobulinemia (HP:0003139)2.37814042
57Parakeratosis (HP:0001036)2.34679128
58Mediastinal lymphadenopathy (HP:0100721)2.34674578
59Hypoplasia of the thymus (HP:0000778)2.27844571
60Inflammation of the large intestine (HP:0002037)2.27167049
61Chronic mucocutaneous candidiasis (HP:0002728)2.25888532
62Recurrent cutaneous fungal infections (HP:0011370)2.25888532
63Hemoptysis (HP:0002105)2.23291523
64Retrobulbar optic neuritis (HP:0100654)2.19049346
65Optic neuritis (HP:0100653)2.19049346
66Vasculitis (HP:0002633)2.18815009
67Abolished electroretinogram (ERG) (HP:0000550)2.15566188
68Abnormal delayed hypersensitivity skin test (HP:0002963)2.15207039
69Conjunctival telangiectasia (HP:0000524)2.14440152
70Pulmonary embolism (HP:0002204)2.14064302
71Abnormality of T cell physiology (HP:0011840)2.12994836
72Gastrointestinal inflammation (HP:0004386)2.08214189
73Aplasia/Hypoplasia of the thymus (HP:0010515)2.08147536
74Abnormality of the columella (HP:0009929)2.06228283
75Orchitis (HP:0100796)2.05182179
76Hepatitis (HP:0012115)2.04202828
77Progressive neurologic deterioration (HP:0002344)2.03476802
78Epistaxis (HP:0000421)2.02125917
79Pulmonary infiltrates (HP:0002113)1.99753739
80Long clavicles (HP:0000890)1.99728564
81Keratoconjunctivitis sicca (HP:0001097)1.95941185
82Recurrent skin infections (HP:0001581)1.93395589
83Decreased activity of mitochondrial respiratory chain (HP:0008972)1.92942505
84Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.92942505
85Increased intramyocellular lipid droplets (HP:0012240)1.92923928
86Spinal canal stenosis (HP:0003416)1.92428652
87Birth length less than 3rd percentile (HP:0003561)1.92067096
88Recurrent gram-negative bacterial infections (HP:0005420)1.91646162
89Keratoconjunctivitis (HP:0001096)1.90596527
90Nasal polyposis (HP:0100582)1.87497762
91Hypochromic microcytic anemia (HP:0004840)1.86872018
92Abnormality of the pleura (HP:0002103)1.84699735
93Generalized aminoaciduria (HP:0002909)1.80728128
94Chest pain (HP:0100749)1.80728049
95Amyotrophic lateral sclerosis (HP:0007354)1.80285648
96Joint swelling (HP:0001386)1.79108488
97Acne (HP:0001061)1.77646804
98Anorexia (HP:0002039)1.76892163
99Vacuolated lymphocytes (HP:0001922)1.76470065
100Agammaglobulinemia (HP:0004432)1.76158370

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK25.80821679
2KDR5.43785807
3MAP3K125.27636547
4MAP4K13.59561595
5TESK13.41415730
6GRK72.99126364
7TXK2.73208999
8BLK2.45222054
9ITK2.33565945
10MAP3K112.13622418
11TGFBR22.12928844
12FES2.06165542
13STK101.93963836
14CSK1.89223211
15RIPK41.74528512
16LIMK11.66756645
17MOS1.66195576
18MYLK1.63398615
19TAOK31.61643584
20ZAP701.60079209
21BUB11.52070092
22CAMKK21.50623582
23GRK61.48941973
24BTK1.43634381
25CLK11.42865133
26MAP3K101.33819247
27LCK1.23220447
28SYK1.22994396
29JAK31.16201287
30TBK11.14905093
31PASK1.10170743
32LYN1.05302314
33TAF11.05152254
34HCK1.03958960
35MAP3K51.01179047
36TYK21.00078139
37SCYL20.97126756
38RPS6KA40.93854250
39GRK50.93311244
40TYRO30.84258442
41JAK20.81722744
42PTK60.81691566
43TEC0.81515150
44WNK40.80868543
45MAP3K30.77636688
46TAOK20.76520098
47MAPK110.74279650
48PRKCH0.73082874
49NTRK20.71548902
50PAK40.71318544
51DAPK10.69759985
52PRKCQ0.69102543
53IKBKE0.68703514
54BCKDK0.68022458
55ILK0.67346122
56MAP2K30.65382184
57CSF1R0.64080787
58MAPKAPK20.63558805
59SIK30.63228458
60ADRBK20.63199026
61TAOK10.62980245
62IRAK40.62166212
63CAMKK10.60304158
64ERN10.58271664
65PDK10.58100369
66JAK10.56951623
67AURKA0.50524709
68FYN0.49559183
69PAK10.49485071
70CDK40.49207968
71NEK60.49027360
72PIM10.47889628
73MAPKAPK30.44938630
74BRSK10.43733029
75TNK20.40538185
76TRPM70.38012454
77MELK0.34955664
78PRPF4B0.34673812
79MARK30.34162409
80GRK10.33663001
81MST40.33375852
82RPS6KA50.33100965
83EPHB10.33046607
84TRIM280.32281120
85MAP3K10.29264783
86KIT0.27974912
87BMPR20.26803402
88IKBKB0.25498315
89CDK60.25261663
90MAP2K20.24693749
91ADRBK10.23965207
92INSR0.23684895
93ROCK10.23314056
94FGR0.22892312
95NLK0.22724965
96DYRK1B0.22146462
97EIF2AK30.20983991
98DAPK20.20681797
99STK390.20162818
100CSNK2A10.18213739

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053406.98835559
2Proteasome_Homo sapiens_hsa030503.55037783
3Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046503.19403717
4Antigen processing and presentation_Homo sapiens_hsa046123.09797854
5T cell receptor signaling pathway_Homo sapiens_hsa046603.07170262
6Hematopoietic cell lineage_Homo sapiens_hsa046402.76402705
7Graft-versus-host disease_Homo sapiens_hsa053322.71227681
8Allograft rejection_Homo sapiens_hsa053302.54082989
9Autoimmune thyroid disease_Homo sapiens_hsa053202.51753464
10Shigellosis_Homo sapiens_hsa051312.38456344
11Measles_Homo sapiens_hsa051622.25020770
12Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.01719874
13Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.99378271
14Type I diabetes mellitus_Homo sapiens_hsa049401.82461929
15Viral myocarditis_Homo sapiens_hsa054161.82249861
16Intestinal immune network for IgA production_Homo sapiens_hsa046721.81156173
17Oxidative phosphorylation_Homo sapiens_hsa001901.77107168
18Salmonella infection_Homo sapiens_hsa051321.73101426
19Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.56550475
20Parkinsons disease_Homo sapiens_hsa050121.53754753
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.49977580
22Malaria_Homo sapiens_hsa051441.49509309
23Alzheimers disease_Homo sapiens_hsa050101.47478445
24NF-kappa B signaling pathway_Homo sapiens_hsa040641.36062811
25Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.35490169
26Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.34333938
27Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.31169654
28Osteoclast differentiation_Homo sapiens_hsa043801.28797668
29RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.27576702
30Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.25095547
31Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.23967383
32Staphylococcus aureus infection_Homo sapiens_hsa051501.23590967
33Leishmaniasis_Homo sapiens_hsa051401.19646640
34Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.12244913
35Prion diseases_Homo sapiens_hsa050201.09548274
36NOD-like receptor signaling pathway_Homo sapiens_hsa046211.08673535
37Pertussis_Homo sapiens_hsa051331.08151280
38Herpes simplex infection_Homo sapiens_hsa051681.05091862
39Legionellosis_Homo sapiens_hsa051340.99177607
40Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.97625010
41Chemokine signaling pathway_Homo sapiens_hsa040620.96578812
42Regulation of autophagy_Homo sapiens_hsa041400.94285924
43Apoptosis_Homo sapiens_hsa042100.94053587
44Endocytosis_Homo sapiens_hsa041440.93529243
45Huntingtons disease_Homo sapiens_hsa050160.91988974
46Tuberculosis_Homo sapiens_hsa051520.90094079
47Epstein-Barr virus infection_Homo sapiens_hsa051690.85040158
48Asthma_Homo sapiens_hsa053100.83400545
49TNF signaling pathway_Homo sapiens_hsa046680.81591757
50Ribosome_Homo sapiens_hsa030100.80942439
51Platelet activation_Homo sapiens_hsa046110.80217463
52One carbon pool by folate_Homo sapiens_hsa006700.78650979
53Jak-STAT signaling pathway_Homo sapiens_hsa046300.78383690
54Cardiac muscle contraction_Homo sapiens_hsa042600.77440648
55SNARE interactions in vesicular transport_Homo sapiens_hsa041300.76266154
56Regulation of actin cytoskeleton_Homo sapiens_hsa048100.75279586
57Influenza A_Homo sapiens_hsa051640.74109011
58Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.74096661
59B cell receptor signaling pathway_Homo sapiens_hsa046620.72602254
60Toll-like receptor signaling pathway_Homo sapiens_hsa046200.72322545
61Leukocyte transendothelial migration_Homo sapiens_hsa046700.71612388
62Rheumatoid arthritis_Homo sapiens_hsa053230.71566069
63Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.71540191
64Hepatitis B_Homo sapiens_hsa051610.63057470
65Protein export_Homo sapiens_hsa030600.60265259
66Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.57137931
67Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.53066882
68Viral carcinogenesis_Homo sapiens_hsa052030.52629748
69HTLV-I infection_Homo sapiens_hsa051660.51449904
70Toxoplasmosis_Homo sapiens_hsa051450.36116539
71Acute myeloid leukemia_Homo sapiens_hsa052210.35404176
72African trypanosomiasis_Homo sapiens_hsa051430.35393691
73Systemic lupus erythematosus_Homo sapiens_hsa053220.31802856
74DNA replication_Homo sapiens_hsa030300.30216758
75Renin secretion_Homo sapiens_hsa049240.26463075
76Phagosome_Homo sapiens_hsa041450.26404705
77Drug metabolism - other enzymes_Homo sapiens_hsa009830.25042894
78Caffeine metabolism_Homo sapiens_hsa002320.22502174
79Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.21956567
80Mineral absorption_Homo sapiens_hsa049780.21560587
81mRNA surveillance pathway_Homo sapiens_hsa030150.20356567
82Sphingolipid signaling pathway_Homo sapiens_hsa040710.18708260
83RNA polymerase_Homo sapiens_hsa030200.17219163
84Spliceosome_Homo sapiens_hsa030400.16719562
85Pancreatic cancer_Homo sapiens_hsa052120.16499065
86Non-homologous end-joining_Homo sapiens_hsa034500.16258243
87MAPK signaling pathway_Homo sapiens_hsa040100.13658041
88Steroid hormone biosynthesis_Homo sapiens_hsa001400.13571963
89Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.12622099
90ABC transporters_Homo sapiens_hsa020100.12448954
91Olfactory transduction_Homo sapiens_hsa047400.11460835
92Phosphatidylinositol signaling system_Homo sapiens_hsa040700.09995669
93Peroxisome_Homo sapiens_hsa041460.09955485
94Hepatitis C_Homo sapiens_hsa051600.09142458
95Other glycan degradation_Homo sapiens_hsa005110.09053209
96Transcriptional misregulation in cancer_Homo sapiens_hsa052020.08891239
97Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.08601249
98Amphetamine addiction_Homo sapiens_hsa050310.07912888
99Adipocytokine signaling pathway_Homo sapiens_hsa049200.05806609
100Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.05297064

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »