TRBV6-1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative T cell selection (GO:0043383)7.88508183
2positive regulation of gamma-delta T cell activation (GO:0046645)7.21991286
3negative thymic T cell selection (GO:0045060)6.98460678
4positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)6.65323275
5antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.52053154
6regulation of T cell tolerance induction (GO:0002664)6.33106470
7regulation of gamma-delta T cell differentiation (GO:0045586)6.18718758
8positive T cell selection (GO:0043368)6.17120434
9Arp2/3 complex-mediated actin nucleation (GO:0034314)5.99563171
10negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.97899581
11negative regulation of cell killing (GO:0031342)5.97899581
12positive regulation of tolerance induction (GO:0002645)5.94277459
13thymic T cell selection (GO:0045061)5.80964388
14cellular response to interleukin-15 (GO:0071350)5.69458755
15positive regulation of interleukin-2 biosynthetic process (GO:0045086)5.58692229
16regulation of gamma-delta T cell activation (GO:0046643)5.52942179
17T cell selection (GO:0045058)5.50878950
18positive thymic T cell selection (GO:0045059)5.48991147
19response to interleukin-15 (GO:0070672)5.36937625
20T cell migration (GO:0072678)5.33072819
21regulation of tolerance induction (GO:0002643)5.27865363
22antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.22802316
23regulation of B cell receptor signaling pathway (GO:0050855)5.19371661
24actin nucleation (GO:0045010)5.12322938
25regulation of regulatory T cell differentiation (GO:0045589)4.98101283
26regulation of alpha-beta T cell proliferation (GO:0046640)4.94088189
27cytidine deamination (GO:0009972)4.90166307
28cytidine metabolic process (GO:0046087)4.90166307
29cytidine catabolic process (GO:0006216)4.90166307
30regulation of isotype switching to IgG isotypes (GO:0048302)4.89786037
31antigen processing and presentation of endogenous antigen (GO:0019883)4.74677781
32antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.68154115
33T cell receptor signaling pathway (GO:0050852)4.50073210
34regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.46595715
35regulation of antigen receptor-mediated signaling pathway (GO:0050854)4.44872608
36regulation of interleukin-2 biosynthetic process (GO:0045076)4.42806063
37regulation of T cell receptor signaling pathway (GO:0050856)4.41240235
38pyrimidine ribonucleoside catabolic process (GO:0046133)4.39290688
39tolerance induction (GO:0002507)4.38809049
40DNA deamination (GO:0045006)4.27534638
41positive regulation of calcium-mediated signaling (GO:0050850)4.19240595
42regulation of natural killer cell mediated cytotoxicity (GO:0042269)4.18600244
43regulation of natural killer cell mediated immunity (GO:0002715)4.18600244
44positive regulation of alpha-beta T cell proliferation (GO:0046641)4.16356757
45regulation of B cell differentiation (GO:0045577)4.08220304
46leukocyte aggregation (GO:0070486)4.03517415
47positive regulation of T cell mediated cytotoxicity (GO:0001916)3.98898077
48antigen receptor-mediated signaling pathway (GO:0050851)3.96618553
49positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.91142156
50positive regulation of natural killer cell mediated immunity (GO:0002717)3.86853318
51negative regulation of T cell mediated immunity (GO:0002710)3.86699043
52regulation of lymphocyte chemotaxis (GO:1901623)3.82846679
53positive regulation of interleukin-2 production (GO:0032743)3.81298717
54regulation of T cell mediated cytotoxicity (GO:0001914)3.79600957
55regulation of leukocyte mediated cytotoxicity (GO:0001910)3.70871259
56negative regulation of lymphocyte mediated immunity (GO:0002707)3.61267678
57positive regulation of lymphocyte migration (GO:2000403)3.59766309
58lymphocyte migration (GO:0072676)3.58893691
59positive regulation of cell killing (GO:0031343)3.58892752
60negative regulation by host of viral transcription (GO:0043922)3.56871546
61positive regulation of macrophage differentiation (GO:0045651)3.52812151
62T cell costimulation (GO:0031295)3.51877406
63positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.49924918
64positive regulation of interleukin-4 production (GO:0032753)3.49382432
65NIK/NF-kappaB signaling (GO:0038061)3.48353986
66lymphocyte costimulation (GO:0031294)3.47854488
67positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.45858465
68regulation of cell killing (GO:0031341)3.45580261
69antigen processing and presentation via MHC class Ib (GO:0002475)3.44299712
70cellular defense response (GO:0006968)3.42302409
71lymphocyte chemotaxis (GO:0048247)3.41630371
72T cell homeostasis (GO:0043029)3.40440635
73Peyers patch development (GO:0048541)3.37149586
74mucosal-associated lymphoid tissue development (GO:0048537)3.37149586
75positive regulation of B cell differentiation (GO:0045579)3.34137408
76negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.31331526
77detection of bacterium (GO:0016045)3.30698512
78negative regulation of leukocyte mediated immunity (GO:0002704)3.26097218
79interferon-gamma production (GO:0032609)3.24668078
80positive regulation of granulocyte differentiation (GO:0030854)3.23159905
81positive regulation of humoral immune response (GO:0002922)3.22928218
82cellular response to type I interferon (GO:0071357)3.22917178
83type I interferon signaling pathway (GO:0060337)3.22917178
84mast cell activation (GO:0045576)3.22054699
85negative regulation of T cell apoptotic process (GO:0070233)3.20313432
86response to type I interferon (GO:0034340)3.17828938
87regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.16289001
88positive regulation of T cell mediated immunity (GO:0002711)3.15497604
89detection of other organism (GO:0098543)3.12410749
90respiratory burst (GO:0045730)3.12001284
91regulation of defense response to virus by virus (GO:0050690)3.11622987
92regulation of interleukin-4 production (GO:0032673)3.10396296
93regulation of alpha-beta T cell activation (GO:0046634)3.09779115
94leukocyte degranulation (GO:0043299)3.08288117
95regulation of lymphocyte migration (GO:2000401)3.07272555
96negative regulation of T cell receptor signaling pathway (GO:0050860)3.02936728
97T cell differentiation (GO:0030217)3.02477197
98regulation of interferon-beta biosynthetic process (GO:0045357)2.97288010
99regulation of interleukin-2 production (GO:0032663)2.96749475
100B cell receptor signaling pathway (GO:0050853)2.96633209

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human7.05894865
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human6.75250034
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.98512602
4IRF8_22096565_ChIP-ChIP_GC-B_Human4.92984811
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.08006153
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.83612216
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.82615259
8RUNX_20019798_ChIP-Seq_JUKART_Human3.67458321
9MYB_26560356_Chip-Seq_TH2_Human3.57054546
10IRF8_21731497_ChIP-ChIP_J774_Mouse3.34609546
11STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.27650143
12STAT4_19710469_ChIP-ChIP_TH1__Mouse3.09163236
13SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.99517046
14MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.96577460
15MAF_26560356_Chip-Seq_TH1_Human2.78956860
16RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.74840481
17FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.73967380
18UTX_26944678_Chip-Seq_JUKART_Human2.70110484
19MYB_26560356_Chip-Seq_TH1_Human2.56516827
20MAF_26560356_Chip-Seq_TH2_Human2.44326719
21GATA3_27048872_Chip-Seq_THYMUS_Human2.27491267
22ELF1_17652178_ChIP-ChIP_JURKAT_Human2.22605238
23SPI1_23547873_ChIP-Seq_NB4_Human2.17391359
24SCL_19346495_ChIP-Seq_HPC-7_Human2.12547782
25SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.07370688
26SMAD_19615063_ChIP-ChIP_OVARY_Human1.95476732
27IRF8_27001747_Chip-Seq_BMDM_Mouse1.90388972
28MYC_22102868_ChIP-Seq_BL_Human1.89745421
29E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.85365391
30LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.85210939
31FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.82791442
32SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.79916550
33NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.75857164
34GATA3_26560356_Chip-Seq_TH2_Human1.74110246
35VDR_24763502_ChIP-Seq_THP-1_Human1.72706428
36RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.70888404
37RUNX1_22412390_ChIP-Seq_EML_Mouse1.68650009
38NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.68045046
39VDR_21846776_ChIP-Seq_THP-1_Human1.65707234
40MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.57307035
41MYB_21317192_ChIP-Seq_ERMYB_Mouse1.54844715
42RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.50774414
43SPI1_23127762_ChIP-Seq_K562_Human1.46537193
44BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.45864964
45CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.43385991
46BRD4_27068464_Chip-Seq_AML-cells_Mouse1.40842507
47LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.37065054
48CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.29261412
49TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.21940992
50NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.19672304
51KDM2B_26808549_Chip-Seq_DND41_Human1.16520106
52CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.16518317
53TCF7_22412390_ChIP-Seq_EML_Mouse1.16077762
54PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.12806637
55CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11728340
56KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.10915752
57VDR_23849224_ChIP-Seq_CD4+_Human1.10305633
58NOTCH1_21737748_ChIP-Seq_TLL_Human1.08153144
59ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.07991578
60CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06702285
61PU.1_20513432_ChIP-Seq_Bcells_Mouse1.05939306
62KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.05932272
63KDM2B_26808549_Chip-Seq_SUP-B15_Human1.05021511
64PU_27001747_Chip-Seq_BMDM_Mouse1.02043756
65SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.01079122
66GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.00136506
67FOXP3_21729870_ChIP-Seq_TREG_Human0.99974049
68PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99565484
69TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99215461
70BCL6_27268052_Chip-Seq_Bcells_Human0.99049024
71GATA2_22383799_ChIP-Seq_G1ME_Mouse0.98297558
72KDM2B_26808549_Chip-Seq_JURKAT_Human0.95203061
73STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.92226840
74SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.91551545
75FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90442698
76VDR_24787735_ChIP-Seq_THP-1_Human0.89590063
77SRY_22984422_ChIP-ChIP_TESTIS_Rat0.88228868
78PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.87080566
79VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.85989035
80CIITA_25753668_ChIP-Seq_RAJI_Human0.85815841
81GATA1_19941827_ChIP-Seq_MEL_Mouse0.85618479
82ELF1_20517297_ChIP-Seq_JURKAT_Human0.85294579
83NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.85203419
84VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.84861755
85GATA3_26560356_Chip-Seq_TH1_Human0.81850170
86CTCF_27219007_Chip-Seq_ERYTHROID_Human0.81282309
87HOXB4_20404135_ChIP-ChIP_EML_Mouse0.79839866
88SA1_27219007_Chip-Seq_Bcells_Human0.78469079
89GATA1_22383799_ChIP-Seq_G1ME_Mouse0.78468027
90GABP_17652178_ChIP-ChIP_JURKAT_Human0.77171507
91TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.75964630
92TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.70724144
93RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.70008908
94RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.69637481
95P300_27268052_Chip-Seq_Bcells_Human0.69466641
96SMRT_27268052_Chip-Seq_Bcells_Human0.68776330
97PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.68624127
98STAT6_21828071_ChIP-Seq_BEAS2B_Human0.66900689
99CTCF_26484167_Chip-Seq_Bcells_Mouse0.66844604
100RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.65722703

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology5.08731463
2MP0005671_abnormal_response_to5.05311204
3MP0009333_abnormal_splenocyte_physiolog4.03185408
4MP0005000_abnormal_immune_tolerance3.40442915
5MP0005387_immune_system_phenotype3.35213635
6MP0001790_abnormal_immune_system3.35213635
7MP0001835_abnormal_antigen_presentation3.33095068
8MP0001800_abnormal_humoral_immune3.31590883
9MP0003436_decreased_susceptibility_to3.27871230
10MP0006082_CNS_inflammation3.25919969
11MP0002723_abnormal_immune_serum2.93779334
12MP0001873_stomach_inflammation2.92185889
13MP0000685_abnormal_immune_system2.89252726
14MP0002420_abnormal_adaptive_immunity2.88524818
15MP0001819_abnormal_immune_cell2.84034188
16MP0009785_altered_susceptibility_to2.77577071
17MP0005025_abnormal_response_to2.74326284
18MP0002148_abnormal_hypersensitivity_rea2.62588098
19MP0002405_respiratory_system_inflammati2.57080756
20MP0002452_abnormal_antigen_presenting2.54876573
21MP0003724_increased_susceptibility_to2.54375324
22MP0003866_abnormal_defecation2.53906375
23MP0000703_abnormal_thymus_morphology2.52741246
24MP0002398_abnormal_bone_marrow2.49689630
25MP0010155_abnormal_intestine_physiology2.39186120
26MP0000716_abnormal_immune_system2.32722485
27MP0002419_abnormal_innate_immunity2.18235652
28MP0002166_altered_tumor_susceptibility2.10762196
29MP0004381_abnormal_hair_follicle2.08035319
30MP0002722_abnormal_immune_system2.05246459
31MP0000689_abnormal_spleen_morphology1.98691037
32MP0003300_gastrointestinal_ulcer1.85990080
33MP0004947_skin_inflammation1.80311809
34MP0001845_abnormal_inflammatory_respons1.77705719
35MP0002277_abnormal_respiratory_mucosa1.76610726
36MP0002429_abnormal_blood_cell1.75441179
37MP0002933_joint_inflammation1.70606591
38MP0005075_abnormal_melanosome_morpholog1.61855080
39MP0000465_gastrointestinal_hemorrhage1.56860199
40MP0005464_abnormal_platelet_physiology1.53232074
41MP0003786_premature_aging1.46164102
42MP0001853_heart_inflammation1.41618406
43MP0001533_abnormal_skeleton_physiology1.41163983
44MP0002006_tumorigenesis1.40374866
45MP0008469_abnormal_protein_level1.26146245
46MP0005310_abnormal_salivary_gland1.22438395
47MP0008007_abnormal_cellular_replicative1.21113785
48MP0003448_altered_tumor_morphology1.09879619
49MP0002132_abnormal_respiratory_system1.08801685
50MP0003303_peritoneal_inflammation1.07455869
51MP0000490_abnormal_crypts_of1.06108257
52MP0002138_abnormal_hepatobiliary_system1.05587571
53MP0001348_abnormal_lacrimal_gland1.05570369
54MP0002009_preneoplasia0.96135393
55MP0008569_lethality_at_weaning0.95065081
56MP0000569_abnormal_digit_pigmentation0.92997803
57MP0002998_abnormal_bone_remodeling0.92942883
58MP0002163_abnormal_gland_morphology0.90281652
59MP0008961_abnormal_basal_metabolism0.89687944
60MP0002019_abnormal_tumor_incidence0.87572004
61MP0009764_decreased_sensitivity_to0.85937742
62MP0002396_abnormal_hematopoietic_system0.85130637
63MP0000858_altered_metastatic_potential0.84056973
64MP0000604_amyloidosis0.83548323
65MP0002693_abnormal_pancreas_physiology0.80957854
66MP0003045_fibrosis0.79621632
67MP0009763_increased_sensitivity_to0.75287893
68MP0001542_abnormal_bone_strength0.74073430
69MP0001919_abnormal_reproductive_system0.70922141
70MP0005166_decreased_susceptibility_to0.69078590
71MP0001851_eye_inflammation0.68383504
72MP0001663_abnormal_digestive_system0.67880733
73MP0001243_abnormal_dermal_layer0.65255169
74MP0003795_abnormal_bone_structure0.64703155
75MP0008873_increased_physiological_sensi0.60577091
76MP0003806_abnormal_nucleotide_metabolis0.59494496
77MP0000609_abnormal_liver_physiology0.56596593
78MP0005390_skeleton_phenotype0.56125369
79MP0000015_abnormal_ear_pigmentation0.52718343
80MP0001765_abnormal_ion_homeostasis0.52102864
81MP0002638_abnormal_pupillary_reflex0.49665794
82MP0000371_diluted_coat_color0.48276881
83MP0004883_abnormal_blood_vessel0.47833647
84MP0005379_endocrine/exocrine_gland_phen0.47092346
85MP0003183_abnormal_peptide_metabolism0.45363295
86MP0000920_abnormal_myelination0.44320259
87MP0008995_early_reproductive_senescence0.41473069
88MP0009765_abnormal_xenobiotic_induced0.39232188
89MP0000477_abnormal_intestine_morphology0.38761462
90MP0003828_pulmonary_edema0.38150996
91MP0002970_abnormal_white_adipose0.37929339
92MP0003638_abnormal_response/metabolism_0.37689435
93MP0005381_digestive/alimentary_phenotyp0.37553010
94MP0002136_abnormal_kidney_physiology0.37434889
95MP0005174_abnormal_tail_pigmentation0.37208325
96MP0005334_abnormal_fat_pad0.36655839
97MP0001905_abnormal_dopamine_level0.36155316
98MP0003172_abnormal_lysosome_physiology0.35337933
99MP0001188_hyperpigmentation0.34188231
100MP0002095_abnormal_skin_pigmentation0.33983198

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of T cell number (HP:0011839)6.51985073
2T lymphocytopenia (HP:0005403)6.46373200
3Stomatitis (HP:0010280)6.41618935
4Autoimmune hemolytic anemia (HP:0001890)6.31931421
5Elevated erythrocyte sedimentation rate (HP:0003565)5.76053891
6Eczematoid dermatitis (HP:0000976)5.27574816
7Severe combined immunodeficiency (HP:0004430)5.14757800
8Increased IgM level (HP:0003496)5.01517155
9Abnormal delayed hypersensitivity skin test (HP:0002963)4.77473308
10Abnormality of T cells (HP:0002843)4.77049302
11Abnormality of eosinophils (HP:0001879)4.65887719
12Eosinophilia (HP:0001880)4.57496115
13Gastrointestinal infarctions (HP:0005244)4.38300643
14Granulocytopenia (HP:0001913)4.31805543
15Myositis (HP:0100614)4.27334399
16IgG deficiency (HP:0004315)4.26330001
17Combined immunodeficiency (HP:0005387)4.08692527
18Leukocytosis (HP:0001974)4.07726469
19Encephalitis (HP:0002383)3.87081258
20Recurrent fungal infections (HP:0002841)3.83953016
21Pustule (HP:0200039)3.69525775
22Meningitis (HP:0001287)3.67491693
23Recurrent bacterial skin infections (HP:0005406)3.66043971
24Autoimmune thrombocytopenia (HP:0001973)3.65830714
25Vasculitis (HP:0002633)3.57504869
26Panhypogammaglobulinemia (HP:0003139)3.55233591
27Abnormality of cells of the lymphoid lineage (HP:0012140)3.54057789
28Lymphopenia (HP:0001888)3.51292494
29Recurrent abscess formation (HP:0002722)3.46069596
30Abnormality of macrophages (HP:0004311)3.45234593
31Chronic obstructive pulmonary disease (HP:0006510)3.42687488
32Obstructive lung disease (HP:0006536)3.42687488
33Optic neuritis (HP:0100653)3.37720352
34Retrobulbar optic neuritis (HP:0100654)3.37720352
35Orchitis (HP:0100796)3.33596808
36Mediastinal lymphadenopathy (HP:0100721)3.27897205
37Chest pain (HP:0100749)3.24719483
38IgM deficiency (HP:0002850)3.23849219
39Abnormality of T cell physiology (HP:0011840)3.20116198
40Increased IgE level (HP:0003212)3.18324422
41Abnormality of the prostate (HP:0008775)3.17479979
42Chronic diarrhea (HP:0002028)3.16870657
43Recurrent viral infections (HP:0004429)3.12277931
44Chronic mucocutaneous candidiasis (HP:0002728)3.12019236
45Recurrent cutaneous fungal infections (HP:0011370)3.12019236
46Thyroiditis (HP:0100646)3.09568236
47Hemiplegia (HP:0002301)3.04385295
48Spontaneous hematomas (HP:0007420)3.01831977
49Hypoproteinemia (HP:0003075)3.00881915
50Recurrent skin infections (HP:0001581)3.00371158
51Hypergammaglobulinemia (HP:0010702)2.99154392
52Pulmonary infiltrates (HP:0002113)2.98069205
53Hypochromic anemia (HP:0001931)2.80883320
54Keratoconjunctivitis sicca (HP:0001097)2.70940797
55Recurrent bronchitis (HP:0002837)2.67905894
56Hemoptysis (HP:0002105)2.62663092
57Lymphoma (HP:0002665)2.60780847
58Keratoconjunctivitis (HP:0001096)2.49409245
59Gangrene (HP:0100758)2.48355300
60Abnormality of B cell number (HP:0010975)2.47662063
61Alveolar cell carcinoma (HP:0006519)2.42107324
62Urticaria (HP:0001025)2.41132027
63Pulmonary embolism (HP:0002204)2.35779172
64Joint swelling (HP:0001386)2.35745974
65Prostate neoplasm (HP:0100787)2.32406504
66Recurrent gram-negative bacterial infections (HP:0005420)2.29783270
67Agammaglobulinemia (HP:0004432)2.28742474
68Amyotrophic lateral sclerosis (HP:0007354)2.25405535
69Inflammation of the large intestine (HP:0002037)2.23484358
70Anorexia (HP:0002039)2.17041011
71Neoplasm of the tracheobronchial system (HP:0100552)2.14066673
72Papilloma (HP:0012740)2.12220155
73Verrucae (HP:0200043)2.12220155
74Hypochromic microcytic anemia (HP:0004840)2.11803158
75Gastrointestinal inflammation (HP:0004386)2.11451847
76Congenital stationary night blindness (HP:0007642)2.10983061
77Gingivitis (HP:0000230)2.09403486
78Acute hepatic failure (HP:0006554)2.07230117
79Sepsis (HP:0100806)2.04196984
80Epistaxis (HP:0000421)2.01865910
81Skin rash (HP:0000988)1.95665601
82Gingival bleeding (HP:0000225)1.93804757
83Abnormality of the pleura (HP:0002103)1.92244355
84Glomerulopathy (HP:0100820)1.91535043
85Amaurosis fugax (HP:0100576)1.90652279
86Prolonged bleeding time (HP:0003010)1.83900561
87Recurrent otitis media (HP:0000403)1.83761288
88Abnormal rod and cone electroretinograms (HP:0008323)1.83752316
89Abnormality of male internal genitalia (HP:0000022)1.83119233
90B lymphocytopenia (HP:0010976)1.79632041
91Basal cell carcinoma (HP:0002671)1.77959775
92Bronchitis (HP:0012387)1.72410871
93Gastrointestinal stroma tumor (HP:0100723)1.71822714
94Arterial thrombosis (HP:0004420)1.71725970
95Renal cortical cysts (HP:0000803)1.70973139
96Hypoplasia of the thymus (HP:0000778)1.68280481
97Ureteral stenosis (HP:0000071)1.66411154
98Ureteral obstruction (HP:0006000)1.65491101
99Diplopia (HP:0000651)1.65415758
100Abnormality of binocular vision (HP:0011514)1.65415758

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK4.97854652
2TESK24.87028951
3MAP4K14.74357158
4KDR4.52102226
5ITK3.61174841
6PASK3.10346788
7ZAP702.81687058
8CSK2.62843937
9IKBKE2.38104155
10TNK22.14562486
11GRK62.09089955
12BTK2.07876508
13EPHB12.05125767
14FES2.03303341
15LCK1.90444741
16RIPK41.84498009
17JAK31.80374564
18SYK1.79608286
19TBK11.72805758
20STK161.69628536
21NLK1.65573462
22PRKCQ1.60573151
23JAK11.51555622
24TEC1.51436404
25CAMKK11.50082453
26TAOK11.43475341
27TYK21.43146410
28TESK11.42771251
29MAP3K111.40517159
30HCK1.38019632
31BUB11.32901587
32EPHA31.31548261
33IKBKB1.30476274
34IRAK41.25976317
35LYN1.17313817
36MARK31.10833892
37TAOK21.07838222
38FGFR41.07583525
39CAMKK21.06596688
40CLK11.06180229
41PRPF4B1.02980341
42MAP2K30.95265083
43CSF1R0.95052993
44TAOK30.94236728
45PRKCH0.92912162
46MAP3K30.86358837
47BLK0.85281716
48JAK20.78055482
49FYN0.71674922
50MAP3K10.70481400
51PIM10.66052720
52MAP3K140.62492365
53ERN10.62326973
54LIMK10.61114974
55IRAK10.59831651
56MAPK120.56885825
57FGFR30.54783160
58SIK30.53334457
59PTK60.51206978
60AKT30.45773783
61SCYL20.45324970
62MAP2K60.44936614
63MAP3K130.44299501
64INSR0.43480079
65MAP3K100.41458670
66PDGFRB0.39602732
67STK100.38471995
68PDK10.37134729
69GRK70.36740279
70PRKD20.36507997
71FGFR10.35613722
72MAPK110.34453611
73MAPKAPK20.34363740
74STK240.34334372
75FGR0.33966496
76HIPK20.33895097
77KIT0.33316865
78MAPK30.32460983
79MAP3K70.30118063
80RPS6KB10.28620312
81CHUK0.27546143
82PAK10.26805102
83MAP2K70.26042014
84RPS6KA50.25697259
85IGF1R0.25242355
86CDK40.20270940
87PRKCD0.18546163
88RPS6KA10.18406915
89EGFR0.17849272
90PRKCA0.14791132
91PIK3CG0.13503055
92TGFBR20.13449261
93MAPKAPK30.13108357
94PTK2B0.12444126
95RPS6KA40.11695191
96MAPK70.11343581
97MAP3K120.10035651
98CDC42BPA0.09549480
99MAPK90.09466950
100CDK190.09121230

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.54487420
2T cell receptor signaling pathway_Homo sapiens_hsa046604.23529918
3Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046503.45564595
4Graft-versus-host disease_Homo sapiens_hsa053323.34025689
5Autoimmune thyroid disease_Homo sapiens_hsa053203.30269889
6Allograft rejection_Homo sapiens_hsa053303.19529193
7Antigen processing and presentation_Homo sapiens_hsa046122.91994169
8Hematopoietic cell lineage_Homo sapiens_hsa046402.80008973
9Measles_Homo sapiens_hsa051622.60390086
10NF-kappa B signaling pathway_Homo sapiens_hsa040642.57533348
11Type I diabetes mellitus_Homo sapiens_hsa049402.32011462
12Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.25411171
13Toll-like receptor signaling pathway_Homo sapiens_hsa046202.02974163
14Osteoclast differentiation_Homo sapiens_hsa043802.00487231
15Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.92739246
16RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.90647923
17Viral myocarditis_Homo sapiens_hsa054161.72625786
18B cell receptor signaling pathway_Homo sapiens_hsa046621.71312432
19Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.66458317
20Salmonella infection_Homo sapiens_hsa051321.62280096
21Chemokine signaling pathway_Homo sapiens_hsa040621.60490097
22Malaria_Homo sapiens_hsa051441.56316361
23Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.51941884
24Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.49478080
25Herpes simplex infection_Homo sapiens_hsa051681.40358342
26Rheumatoid arthritis_Homo sapiens_hsa053231.39783746
27Leishmaniasis_Homo sapiens_hsa051401.38427639
28Intestinal immune network for IgA production_Homo sapiens_hsa046721.35124486
29NOD-like receptor signaling pathway_Homo sapiens_hsa046211.34445917
30Proteasome_Homo sapiens_hsa030501.32430978
31Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.32324751
32TNF signaling pathway_Homo sapiens_hsa046681.28608949
33Shigellosis_Homo sapiens_hsa051311.25535593
34Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.20483941
35Jak-STAT signaling pathway_Homo sapiens_hsa046301.19786016
36Staphylococcus aureus infection_Homo sapiens_hsa051501.13756994
37Tuberculosis_Homo sapiens_hsa051521.00871760
38Acute myeloid leukemia_Homo sapiens_hsa052210.99365225
39Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.95091734
40VEGF signaling pathway_Homo sapiens_hsa043700.93091239
41Viral carcinogenesis_Homo sapiens_hsa052030.87754052
42HTLV-I infection_Homo sapiens_hsa051660.85119019
43Leukocyte transendothelial migration_Homo sapiens_hsa046700.84523470
44African trypanosomiasis_Homo sapiens_hsa051430.84311452
45Influenza A_Homo sapiens_hsa051640.84240389
46Hepatitis B_Homo sapiens_hsa051610.83343496
47Apoptosis_Homo sapiens_hsa042100.82171828
48Asthma_Homo sapiens_hsa053100.78443466
49Epstein-Barr virus infection_Homo sapiens_hsa051690.76135412
50SNARE interactions in vesicular transport_Homo sapiens_hsa041300.75641285
51Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.72852972
52Pertussis_Homo sapiens_hsa051330.70635626
53Platelet activation_Homo sapiens_hsa046110.65844805
54Toxoplasmosis_Homo sapiens_hsa051450.64172547
55Hepatitis C_Homo sapiens_hsa051600.60564367
56Endocytosis_Homo sapiens_hsa041440.56543596
57Legionellosis_Homo sapiens_hsa051340.56366414
58Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.54465802
59Colorectal cancer_Homo sapiens_hsa052100.53603843
60Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.51176554
61MAPK signaling pathway_Homo sapiens_hsa040100.50366938
62Non-small cell lung cancer_Homo sapiens_hsa052230.47947057
63Rap1 signaling pathway_Homo sapiens_hsa040150.46115602
64Long-term potentiation_Homo sapiens_hsa047200.45811061
65Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.40951367
66Pancreatic cancer_Homo sapiens_hsa052120.40749594
67AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.39609194
68Transcriptional misregulation in cancer_Homo sapiens_hsa052020.36456400
69Prolactin signaling pathway_Homo sapiens_hsa049170.36166263
70Regulation of actin cytoskeleton_Homo sapiens_hsa048100.33665961
71Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.33582305
72Phagosome_Homo sapiens_hsa041450.32670869
73Phototransduction_Homo sapiens_hsa047440.32541459
74Neurotrophin signaling pathway_Homo sapiens_hsa047220.32143545
75Chronic myeloid leukemia_Homo sapiens_hsa052200.31246195
76Renal cell carcinoma_Homo sapiens_hsa052110.29631911
77Adipocytokine signaling pathway_Homo sapiens_hsa049200.29445560
78FoxO signaling pathway_Homo sapiens_hsa040680.29232831
79Ribosome_Homo sapiens_hsa030100.29116931
80Ras signaling pathway_Homo sapiens_hsa040140.25629325
81Thyroid cancer_Homo sapiens_hsa052160.23870253
82HIF-1 signaling pathway_Homo sapiens_hsa040660.22958354
83Notch signaling pathway_Homo sapiens_hsa043300.22315242
84Renin secretion_Homo sapiens_hsa049240.21115843
85Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.20781604
86Sphingolipid signaling pathway_Homo sapiens_hsa040710.19615956
87Endometrial cancer_Homo sapiens_hsa052130.19579241
88Regulation of autophagy_Homo sapiens_hsa041400.19301540
89Basal transcription factors_Homo sapiens_hsa030220.18898218
90Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.15436879
91Collecting duct acid secretion_Homo sapiens_hsa049660.13588300
92Systemic lupus erythematosus_Homo sapiens_hsa053220.13486490
93Aldosterone synthesis and secretion_Homo sapiens_hsa049250.13305798
94Phosphatidylinositol signaling system_Homo sapiens_hsa040700.12777523
95Oxidative phosphorylation_Homo sapiens_hsa001900.10738230
96Pentose phosphate pathway_Homo sapiens_hsa000300.09740077
97cAMP signaling pathway_Homo sapiens_hsa040240.09498362
98Insulin resistance_Homo sapiens_hsa049310.08320356
99Olfactory transduction_Homo sapiens_hsa047400.05074395
100Pathways in cancer_Homo sapiens_hsa052000.04220199

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