TRBV6-3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450917.70341351
2antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G7.55143304
3cytidine catabolic process (GO:0006216)7.12416935
4cytidine deamination (GO:0009972)7.12416935
5cytidine metabolic process (GO:0046087)7.12416935
6negative T cell selection (GO:0043383)6.67527783
7pyrimidine ribonucleoside catabolic process (GO:0046133)6.33663447
8negative regulation of cell killing (GO:0031342)6.32310137
9negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.32310137
10DNA deamination (GO:0045006)6.32238721
11positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)6.31980878
12positive T cell selection (GO:0043368)6.22311089
13positive regulation of T cell mediated cytotoxicity (GO:0001916)6.03709973
14cellular response to interferon-beta (GO:0035458)5.85728175
15cellular response to interleukin-15 (GO:0071350)5.73083121
16activated T cell proliferation (GO:0050798)5.46346536
17regulation of T cell mediated cytotoxicity (GO:0001914)5.45185339
18positive regulation of leukocyte mediated cytotoxicity (GO:0001912)5.32030168
19positive regulation of interleukin-2 biosynthetic process (GO:0045086)5.30809661
20response to interleukin-15 (GO:0070672)5.30374424
21positive regulation of defense response to virus by host (GO:0002230)5.28247041
22negative regulation of stress fiber assembly (GO:0051497)5.18396799
23negative thymic T cell selection (GO:0045060)5.12774902
24antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.01993511
25T cell migration (GO:0072678)4.85717217
26negative regulation of T cell mediated immunity (GO:0002710)4.85091982
27regulation of leukocyte mediated cytotoxicity (GO:0001910)4.84979772
28response to interferon-beta (GO:0035456)4.83981125
29positive regulation of cell killing (GO:0031343)4.77460070
30positive regulation of gamma-delta T cell activation (GO:0046645)4.70581428
31T cell selection (GO:0045058)4.67170304
32cellular defense response (GO:0006968)4.64675554
33positive thymic T cell selection (GO:0045059)4.61512981
34regulation of natural killer cell mediated cytotoxicity (GO:0042269)4.53796172
35regulation of natural killer cell mediated immunity (GO:0002715)4.53796172
36antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.42310144
37positive regulation of natural killer cell mediated immunity (GO:0002717)4.42228796
38regulation of interleukin-2 biosynthetic process (GO:0045076)4.36197298
39regulation of cell killing (GO:0031341)4.35043266
40antigen processing and presentation of endogenous antigen (GO:0019883)4.32787921
41thymic T cell selection (GO:0045061)4.30841343
42positive regulation of B cell differentiation (GO:0045579)4.29921119
43regulation of isotype switching to IgG isotypes (GO:0048302)4.29124561
44antigen processing and presentation via MHC class Ib (GO:0002475)4.23234470
45negative regulation of T cell apoptotic process (GO:0070233)4.18417783
46negative regulation of interleukin-12 production (GO:0032695)4.18036810
47negative regulation of lymphocyte mediated immunity (GO:0002707)4.14686473
48regulation of B cell differentiation (GO:0045577)4.13817253
49negative regulation of actin filament bundle assembly (GO:0032232)4.10724850
50positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)4.07116148
51regulation of regulatory T cell differentiation (GO:0045589)3.99090017
52positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.98704318
53regulation of defense response to virus by host (GO:0050691)3.90791787
54regulation of gamma-delta T cell differentiation (GO:0045586)3.89227236
55regulation of alpha-beta T cell proliferation (GO:0046640)3.85540938
56regulation of T cell tolerance induction (GO:0002664)3.79417274
57positive regulation of T cell mediated immunity (GO:0002711)3.77397594
58T cell receptor signaling pathway (GO:0050852)3.73222498
59regulation of gamma-delta T cell activation (GO:0046643)3.67125600
60signal complex assembly (GO:0007172)3.65200786
61cytolysis (GO:0019835)3.64690551
62pentose metabolic process (GO:0019321)3.62676468
63positive regulation of alpha-beta T cell proliferation (GO:0046641)3.60472415
64positive regulation of humoral immune response (GO:0002922)3.60377860
65regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.58713073
66interferon-gamma production (GO:0032609)3.55172592
67lymphocyte migration (GO:0072676)3.54519050
68positive regulation of calcium-mediated signaling (GO:0050850)3.52782894
69positive regulation of lymphocyte mediated immunity (GO:0002708)3.48312967
70positive regulation of interleukin-4 production (GO:0032753)3.44002854
71pyrimidine nucleoside catabolic process (GO:0046135)3.40508261
72positive regulation of granulocyte differentiation (GO:0030854)3.40301638
73tolerance induction (GO:0002507)3.40076534
74negative regulation of leukocyte mediated immunity (GO:0002704)3.37516633
75regulation of T cell mediated immunity (GO:0002709)3.36664876
76heart trabecula morphogenesis (GO:0061384)3.34892784
77NIK/NF-kappaB signaling (GO:0038061)3.33120291
78CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.32355621
79positive regulation of tolerance induction (GO:0002645)3.32049500
80regulation of interleukin-12 biosynthetic process (GO:0045075)3.30700587
81trabecula morphogenesis (GO:0061383)3.30494740
82protein localization to microtubule (GO:0035372)3.24931628
83blood vessel maturation (GO:0001955)3.23794559
84antigen receptor-mediated signaling pathway (GO:0050851)3.23722980
85regulation of B cell receptor signaling pathway (GO:0050855)3.19681927
86positive regulation of immunoglobulin mediated immune response (GO:0002891)3.15394354
87positive regulation of B cell mediated immunity (GO:0002714)3.15394354
88regulation of T cell apoptotic process (GO:0070232)3.08908108
89regulation of tolerance induction (GO:0002643)3.08533548
90positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.08185286
91negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.07606174
92positive regulation of leukocyte mediated immunity (GO:0002705)3.05239987
93regulation of platelet aggregation (GO:0090330)3.03864270
94leukocyte aggregation (GO:0070486)3.02773131
95regulation of lymphocyte mediated immunity (GO:0002706)3.02560612
96positive regulation of adaptive immune response based on somatic recombination of immune receptors b3.01772250
97positive regulation of isotype switching (GO:0045830)3.01585707
98negative regulation of viral genome replication (GO:0045071)3.01261471
99regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.95991900
100regulation of lymphocyte chemotaxis (GO:1901623)2.92565575

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse7.42803940
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human6.46148950
3BP1_19119308_ChIP-ChIP_Hs578T_Human5.16178362
4CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human4.49483445
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.05504278
6IRF8_22096565_ChIP-ChIP_GC-B_Human3.87028751
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.79583794
8RUNX_20019798_ChIP-Seq_JUKART_Human3.50160937
9TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.37561748
10STAT4_19710469_ChIP-ChIP_TH1__Mouse3.27344636
11IRF8_21731497_ChIP-ChIP_J774_Mouse3.23985195
12MYB_26560356_Chip-Seq_TH2_Human3.23401290
13STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.18287307
14MAF_26560356_Chip-Seq_TH1_Human2.41834144
15FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.33112809
16MYB_26560356_Chip-Seq_TH1_Human2.18013278
17ELF1_17652178_ChIP-ChIP_JURKAT_Human2.17985330
18SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.15413767
19VDR_22108803_ChIP-Seq_LS180_Human2.14500797
20GATA3_26560356_Chip-Seq_TH2_Human2.11057858
21GATA3_27048872_Chip-Seq_THYMUS_Human2.07780780
22SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.06143470
23E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.05882021
24NOTCH1_21737748_ChIP-Seq_TLL_Human2.04420668
25MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.02264470
26CIITA_25753668_ChIP-Seq_RAJI_Human1.94005457
27UTX_26944678_Chip-Seq_JUKART_Human1.90065039
28MAF_26560356_Chip-Seq_TH2_Human1.89017417
29RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.74683110
30RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.68370658
31SPI1_23547873_ChIP-Seq_NB4_Human1.66876629
32IRF8_27001747_Chip-Seq_BMDM_Mouse1.66429038
33MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.62183715
34VDR_23849224_ChIP-Seq_CD4+_Human1.56864433
35FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.49206889
36CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.48075642
37LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.47334793
38E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.45781329
39FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.44725288
40HTT_18923047_ChIP-ChIP_STHdh_Human1.32938469
41GABP_17652178_ChIP-ChIP_JURKAT_Human1.32615243
42RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.27801948
43NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.26380636
44TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.25911472
45GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.25766357
46RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.25530623
47PCGF2_27294783_Chip-Seq_NPCs_Mouse1.23998653
48SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.21396987
49RUNX1_22412390_ChIP-Seq_EML_Mouse1.20548237
50SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.17737532
51FOXP3_21729870_ChIP-Seq_TREG_Human1.16127726
52LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.15916106
53CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.14899799
54RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.13990174
55MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.11661436
56PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.10513448
57STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.08453850
58EST1_17652178_ChIP-ChIP_JURKAT_Human1.06093250
59FLI1_27457419_Chip-Seq_LIVER_Mouse1.02790649
60MYB_21317192_ChIP-Seq_ERMYB_Mouse1.01283041
61CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99983700
62CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97911817
63HOXB4_20404135_ChIP-ChIP_EML_Mouse0.97451930
64JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.97107295
65GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.95334506
66TP53_22573176_ChIP-Seq_HFKS_Human0.92822092
67EGR1_23403033_ChIP-Seq_LIVER_Mouse0.91343028
68TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.90847180
69YY1_21170310_ChIP-Seq_MESCs_Mouse0.89673512
70GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.88020137
71STAT1_20625510_ChIP-Seq_HELA_Human0.87424046
72SMRT_27268052_Chip-Seq_Bcells_Human0.86140298
73HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.85101421
74GATA3_26560356_Chip-Seq_TH1_Human0.84063775
75BCL6_27268052_Chip-Seq_Bcells_Human0.83699395
76AUTS2_25519132_ChIP-Seq_293T-REX_Human0.83078987
77FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82865776
78P300_27268052_Chip-Seq_Bcells_Human0.82481571
79SRF_21415370_ChIP-Seq_HL-1_Mouse0.82378477
80ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.81231303
81BCOR_27268052_Chip-Seq_Bcells_Human0.80899712
82VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.80376251
83PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.80172483
84GATA1_19941827_ChIP-Seq_MEL_Mouse0.80122450
85STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.79857446
86SMAD_19615063_ChIP-ChIP_OVARY_Human0.79608831
87SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.77828580
88CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.77058357
89GATA2_22383799_ChIP-Seq_G1ME_Mouse0.76355943
90BRD4_27068464_Chip-Seq_AML-cells_Mouse0.74969449
91TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.74925372
92SUZ12_27294783_Chip-Seq_NPCs_Mouse0.74824694
93PU.1_20513432_ChIP-Seq_Bcells_Mouse0.74295058
94GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.74062849
95VDR_24763502_ChIP-Seq_THP-1_Human0.73741287
96VDR_24787735_ChIP-Seq_THP-1_Human0.72997328
97KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.72507195
98KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.72507195
99KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.72507195
100SPI1_23127762_ChIP-Seq_K562_Human0.70353076

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to5.01680702
2MP0003763_abnormal_thymus_physiology4.26654250
3MP0009333_abnormal_splenocyte_physiolog4.12581967
4MP0001835_abnormal_antigen_presentation3.82426774
5MP0001853_heart_inflammation3.32672434
6MP0000685_abnormal_immune_system3.10819842
7MP0005387_immune_system_phenotype2.78107481
8MP0001790_abnormal_immune_system2.78107481
9MP0003878_abnormal_ear_physiology2.76884143
10MP0005377_hearing/vestibular/ear_phenot2.76884143
11MP0001800_abnormal_humoral_immune2.67638768
12MP0002837_dystrophic_cardiac_calcinosis2.67336610
13MP0002138_abnormal_hepatobiliary_system2.64619920
14MP0009785_altered_susceptibility_to2.61802890
15MP0003436_decreased_susceptibility_to2.49994968
16MP0005025_abnormal_response_to2.49101771
17MP0002420_abnormal_adaptive_immunity2.47250131
18MP0001819_abnormal_immune_cell2.41296052
19MP0005000_abnormal_immune_tolerance2.37992239
20MP0002723_abnormal_immune_serum2.36227590
21MP0003866_abnormal_defecation2.36063849
22MP0002166_altered_tumor_susceptibility2.21123638
23MP0000703_abnormal_thymus_morphology2.14947049
24MP0002452_abnormal_antigen_presenting2.13774008
25MP0002405_respiratory_system_inflammati2.03220917
26MP0002419_abnormal_innate_immunity1.98509529
27MP0006082_CNS_inflammation1.96948809
28MP0000716_abnormal_immune_system1.95497980
29MP0002398_abnormal_bone_marrow1.90399863
30MP0002148_abnormal_hypersensitivity_rea1.88558080
31MP0003045_fibrosis1.85527258
32MP0001873_stomach_inflammation1.80875322
33MP0000689_abnormal_spleen_morphology1.80237105
34MP0010155_abnormal_intestine_physiology1.80164721
35MP0002722_abnormal_immune_system1.58448105
36MP0003448_altered_tumor_morphology1.48961841
37MP0002429_abnormal_blood_cell1.48647241
38MP0005310_abnormal_salivary_gland1.46589117
39MP0002006_tumorigenesis1.45036715
40MP0003300_gastrointestinal_ulcer1.44729642
41MP0001845_abnormal_inflammatory_respons1.40134387
42MP0005379_endocrine/exocrine_gland_phen1.39589065
43MP0001764_abnormal_homeostasis1.39448472
44MP0002163_abnormal_gland_morphology1.35067636
45MP0008469_abnormal_protein_level1.30019275
46MP0004130_abnormal_muscle_cell1.29266288
47MP0002736_abnormal_nociception_after1.22040428
48MP0003724_increased_susceptibility_to1.20036741
49MP0004036_abnormal_muscle_relaxation1.18943177
50MP0001501_abnormal_sleep_pattern1.16685083
51MP0001765_abnormal_ion_homeostasis1.16294391
52MP0004381_abnormal_hair_follicle1.15296202
53MP0004947_skin_inflammation1.11249642
54MP0005464_abnormal_platelet_physiology1.09308827
55MP0009763_increased_sensitivity_to1.06122562
56MP0002277_abnormal_respiratory_mucosa1.03403992
57MP0002254_reproductive_system_inflammat1.03166338
58MP0001348_abnormal_lacrimal_gland1.02328872
59MP0004084_abnormal_cardiac_muscle1.02199921
60MP0009764_decreased_sensitivity_to1.01886036
61MP0002998_abnormal_bone_remodeling0.97011964
62MP0005646_abnormal_pituitary_gland0.96985276
63MP0000604_amyloidosis0.96483178
64MP0004142_abnormal_muscle_tone0.96401714
65MP0003959_abnormal_lean_body0.94776778
66MP0005165_increased_susceptibility_to0.94365408
67MP0001968_abnormal_touch/_nociception0.92818307
68MP0005410_abnormal_fertilization0.91312172
69MP0005083_abnormal_biliary_tract0.89263025
70MP0004185_abnormal_adipocyte_glucose0.87704374
71MP0008775_abnormal_heart_ventricle0.86532316
72MP0005636_abnormal_mineral_homeostasis0.83281469
73MP0009278_abnormal_bone_marrow0.82696151
74MP0000858_altered_metastatic_potential0.82509733
75MP0001986_abnormal_taste_sensitivity0.78360649
76MP0001533_abnormal_skeleton_physiology0.78308982
77MP0006035_abnormal_mitochondrial_morpho0.77872866
78MP0005448_abnormal_energy_balance0.77113306
79MP0008057_abnormal_DNA_replication0.75063640
80MP0005075_abnormal_melanosome_morpholog0.74833666
81MP0005167_abnormal_blood-brain_barrier0.73013287
82MP0006054_spinal_hemorrhage0.72675182
83MP0005584_abnormal_enzyme/coenzyme_acti0.70412254
84MP0008872_abnormal_physiological_respon0.68974259
85MP0005645_abnormal_hypothalamus_physiol0.68277663
86MP0001919_abnormal_reproductive_system0.66144941
87MP0009840_abnormal_foam_cell0.66112198
88MP0001727_abnormal_embryo_implantation0.65246857
89MP0004782_abnormal_surfactant_physiolog0.63250252
90MP0003252_abnormal_bile_duct0.62760096
91MP0005376_homeostasis/metabolism_phenot0.60866722
92MP0002693_abnormal_pancreas_physiology0.58577901
93MP0004264_abnormal_extraembryonic_tissu0.57146505
94MP0002019_abnormal_tumor_incidence0.56841887
95MP0002933_joint_inflammation0.56825040
96MP0005535_abnormal_body_temperature0.54601922
97MP0002127_abnormal_cardiovascular_syste0.54223239
98MP0003075_altered_response_to0.53282721
99MP0003943_abnormal_hepatobiliary_system0.51437644
100MP0005319_abnormal_enzyme/_coenzyme0.50933908

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)7.64439362
2Recurrent cutaneous fungal infections (HP:0011370)5.94111825
3Chronic mucocutaneous candidiasis (HP:0002728)5.94111825
4Abnormal delayed hypersensitivity skin test (HP:0002963)5.73129653
5T lymphocytopenia (HP:0005403)5.25502918
6Panhypogammaglobulinemia (HP:0003139)5.22103670
7Abnormality of T cells (HP:0002843)4.96608539
8Agammaglobulinemia (HP:0004432)4.85534754
9Stomatitis (HP:0010280)4.83569044
10Recurrent fungal infections (HP:0002841)4.83287881
11Abnormality of T cell number (HP:0011839)4.77956007
12Eczematoid dermatitis (HP:0000976)4.63736163
13IgG deficiency (HP:0004315)4.46230398
14Encephalitis (HP:0002383)4.42981508
15Severe combined immunodeficiency (HP:0004430)4.41498149
16Colitis (HP:0002583)4.40515692
17Pigmentary retinal degeneration (HP:0001146)4.10613132
18Increased IgE level (HP:0003212)3.88041511
19Abnormality of eosinophils (HP:0001879)3.79322703
20Recurrent bronchitis (HP:0002837)3.64865934
21Chronic diarrhea (HP:0002028)3.59095677
22Hypoplasia of the thymus (HP:0000778)3.56657672
23Recurrent skin infections (HP:0001581)3.46189429
24Increased IgM level (HP:0003496)3.43920596
25Combined immunodeficiency (HP:0005387)3.42762366
26Thyroiditis (HP:0100646)3.41158415
27Leukocytosis (HP:0001974)3.40677792
28Abnormality of T cell physiology (HP:0011840)3.38779966
29Inflammation of the large intestine (HP:0002037)3.34296746
30Viral hepatitis (HP:0006562)3.34160288
31Pustule (HP:0200039)3.29904666
32Abnormality of small intestinal villus morphology (HP:0011472)3.23063567
33Villous atrophy (HP:0011473)3.23063567
34Myositis (HP:0100614)3.19990896
35Meningitis (HP:0001287)3.13241298
36Severe visual impairment (HP:0001141)3.11581633
37Aplastic anemia (HP:0001915)3.10679187
38Eosinophilia (HP:0001880)3.10503586
39Gastrointestinal inflammation (HP:0004386)3.09320135
40Lymphopenia (HP:0001888)3.04300935
41Autoimmune hemolytic anemia (HP:0001890)3.03488576
42Recurrent viral infections (HP:0004429)2.98778773
43Vasculitis (HP:0002633)2.93073442
44Petechiae (HP:0000967)2.92147157
45Abnormality of cells of the lymphoid lineage (HP:0012140)2.74899536
46Optic neuritis (HP:0100653)2.73912069
47Retrobulbar optic neuritis (HP:0100654)2.73912069
48Granulocytopenia (HP:0001913)2.70191205
49Orchitis (HP:0100796)2.61805813
50Abnormality of macrophages (HP:0004311)2.59726006
51Hypergammaglobulinemia (HP:0010702)2.58994097
52Alveolar cell carcinoma (HP:0006519)2.58010568
53Absent rod-and cone-mediated responses on ERG (HP:0007688)2.51925955
54Abnormal rod and cone electroretinograms (HP:0008323)2.51810213
55Carpal bone hypoplasia (HP:0001498)2.50696160
56Recurrent bacterial skin infections (HP:0005406)2.44102664
57Prolonged neonatal jaundice (HP:0006579)2.43127787
58Pulmonary infiltrates (HP:0002113)2.37709539
59Keratoconjunctivitis sicca (HP:0001097)2.35171986
60Recurrent abscess formation (HP:0002722)2.34114530
61Purpura (HP:0000979)2.32177452
62Lymphoma (HP:0002665)2.31869430
63Tetraplegia (HP:0002445)2.29653275
64J-shaped sella turcica (HP:0002680)2.26480531
65Hyperlipoproteinemia (HP:0010980)2.24956156
66Poor head control (HP:0002421)2.24147043
67Acute hepatic failure (HP:0006554)2.22515667
68Congenital stationary night blindness (HP:0007642)2.20910709
69Hepatosplenomegaly (HP:0001433)2.20597469
70Abnormality of the pleura (HP:0002103)2.20308854
71Neoplasm of the tracheobronchial system (HP:0100552)2.20019071
72Neutropenia (HP:0001875)2.16131892
73Keratoconjunctivitis (HP:0001096)2.14951994
74Interstitial pulmonary disease (HP:0006530)2.07620010
75Porencephaly (HP:0002132)2.04521985
76Hepatitis (HP:0012115)2.02964947
77Micronodular cirrhosis (HP:0001413)2.01368500
78Lower limb hyperreflexia (HP:0002395)1.97412828
79Hypoproteinemia (HP:0003075)1.96249309
80Mediastinal lymphadenopathy (HP:0100721)1.95973072
81Microcytic anemia (HP:0001935)1.94850185
82Glomerulopathy (HP:0100820)1.93725695
83Gonadal dysgenesis (HP:0000133)1.91482906
84Adactyly (HP:0009776)1.88704763
85Systemic lupus erythematosus (HP:0002725)1.88412212
86Skin rash (HP:0000988)1.87592024
87Thyroid-stimulating hormone excess (HP:0002925)1.87324022
88Homocystinuria (HP:0002156)1.87041807
89Abnormality of homocysteine metabolism (HP:0010919)1.87041807
90Cellular immunodeficiency (HP:0005374)1.86899814
91Basal ganglia calcification (HP:0002135)1.86419786
92Persistence of primary teeth (HP:0006335)1.86403196
93Gastrointestinal infarctions (HP:0005244)1.86389175
94Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.84615542
95Bronchitis (HP:0012387)1.84313127
96Arthropathy (HP:0003040)1.82518433
97Segmental peripheral demyelination/remyelination (HP:0003481)1.79017151
98Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.78598633
99Cleft eyelid (HP:0000625)1.77793406
100Methylmalonic acidemia (HP:0002912)1.75572265

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK6.72864326
2EPHA34.93683699
3MAP4K14.45317634
4EPHB14.00955393
5TNK23.42005565
6IRAK43.33961384
7FGFR42.97980582
8RPS6KA42.85550495
9FES2.68870195
10MAP3K32.61386852
11MAP2K32.49558649
12BCKDK2.18757269
13NLK2.06460377
14TESK21.85909816
15ITK1.76047512
16IRAK11.69685793
17FGFR31.54741891
18KDR1.48600163
19TAOK31.47519382
20MAP3K11.45932359
21CSK1.45450674
22TAOK21.43539653
23ADRBK21.37123349
24ZAP701.27991960
25TAOK11.23941341
26MAP3K111.16597429
27JAK11.10315485
28TEC1.08147728
29HCK1.06313668
30TYK21.06011390
31LCK1.05120439
32HIPK21.04414004
33RPS6KA51.02518799
34BTK1.01021536
35IKBKE0.98489036
36SYK0.96207452
37RAF10.89257798
38NUAK10.87742498
39GRK70.87730091
40IKBKB0.86816442
41SGK20.86787520
42PRKCQ0.84615957
43MAPK120.84600977
44CDK190.82831983
45SRPK10.82396752
46PTK2B0.79495995
47MAP2K70.77101843
48GRK60.76790582
49NEK90.76007029
50SGK30.75957524
51LYN0.75627483
52PASK0.74784578
53MAP3K130.74694454
54TBK10.73138978
55CLK10.62285924
56BLK0.59254389
57CSF1R0.58848621
58SGK4940.58523680
59SGK2230.58523680
60TESK10.53206283
61JAK30.52729092
62MAP3K80.50974355
63RIPK40.50614691
64DYRK20.49200669
65CHUK0.48852849
66FGR0.45990219
67MAP2K60.45976401
68MST40.45933328
69TYRO30.44785377
70CAMKK20.44452660
71PINK10.43985261
72JAK20.43295990
73NEK60.42719487
74DYRK30.40773396
75AKT30.40629019
76FER0.38341552
77MAP3K120.34879147
78MAPKAPK20.32610395
79ILK0.31091248
80MAPK110.30707818
81CAMK10.30429435
82ALK0.29618695
83FYN0.26982763
84MAP3K60.26751523
85WNK40.24202585
86CAMKK10.22833840
87KSR20.19479434
88CAMK40.16663427
89PAK30.15849165
90ERN10.15453005
91MELK0.15130793
92PAK60.14478754
93MARK30.14414269
94WNK10.14295669
95KIT0.14164891
96IGF1R0.13416410
97DMPK0.13146828
98RET0.13140932
99CDK40.12925732
100CAMK2A0.12790890

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.89425005
2Antigen processing and presentation_Homo sapiens_hsa046125.39993984
3Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046504.20010926
4Graft-versus-host disease_Homo sapiens_hsa053323.59306508
5Autoimmune thyroid disease_Homo sapiens_hsa053203.55770823
6Allograft rejection_Homo sapiens_hsa053303.48959088
7T cell receptor signaling pathway_Homo sapiens_hsa046602.93143921
8Type I diabetes mellitus_Homo sapiens_hsa049402.81190186
9Measles_Homo sapiens_hsa051622.28403052
10Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.20207232
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.99831851
12NF-kappa B signaling pathway_Homo sapiens_hsa040641.90135053
13Proteasome_Homo sapiens_hsa030501.78449726
14Hematopoietic cell lineage_Homo sapiens_hsa046401.62992870
15Viral myocarditis_Homo sapiens_hsa054161.36741384
16Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.34613360
17Intestinal immune network for IgA production_Homo sapiens_hsa046721.32667042
18Jak-STAT signaling pathway_Homo sapiens_hsa046301.31289608
19Osteoclast differentiation_Homo sapiens_hsa043801.30595969
20Malaria_Homo sapiens_hsa051441.29943261
21RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.18051364
22Toll-like receptor signaling pathway_Homo sapiens_hsa046201.17899853
23Chemokine signaling pathway_Homo sapiens_hsa040621.17620011
24Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.13225696
25Shigellosis_Homo sapiens_hsa051311.09954622
26Phototransduction_Homo sapiens_hsa047441.03552986
27Oxidative phosphorylation_Homo sapiens_hsa001901.02823594
28TNF signaling pathway_Homo sapiens_hsa046681.01219892
29Asthma_Homo sapiens_hsa053100.97248348
30Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.96545205
31Collecting duct acid secretion_Homo sapiens_hsa049660.95790250
32Acute myeloid leukemia_Homo sapiens_hsa052210.95381246
33Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.94557295
34Rheumatoid arthritis_Homo sapiens_hsa053230.94090276
35Tuberculosis_Homo sapiens_hsa051520.93321364
36Toxoplasmosis_Homo sapiens_hsa051450.90385709
37Leishmaniasis_Homo sapiens_hsa051400.86922703
38Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.85872213
39Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.84388152
40Epstein-Barr virus infection_Homo sapiens_hsa051690.84050288
412-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.82651367
42Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.81874221
43Protein export_Homo sapiens_hsa030600.80019412
44Ribosome_Homo sapiens_hsa030100.79091584
45Apoptosis_Homo sapiens_hsa042100.78206000
46Parkinsons disease_Homo sapiens_hsa050120.77941685
47B cell receptor signaling pathway_Homo sapiens_hsa046620.75810632
48Staphylococcus aureus infection_Homo sapiens_hsa051500.70416095
49Hepatitis B_Homo sapiens_hsa051610.67953063
50Herpes simplex infection_Homo sapiens_hsa051680.65939194
51Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.64127550
52Adipocytokine signaling pathway_Homo sapiens_hsa049200.62587473
53HTLV-I infection_Homo sapiens_hsa051660.61406551
54Renin secretion_Homo sapiens_hsa049240.61012832
55Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.60761306
56Nitrogen metabolism_Homo sapiens_hsa009100.57973671
57Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.57423914
58VEGF signaling pathway_Homo sapiens_hsa043700.56865007
59Viral carcinogenesis_Homo sapiens_hsa052030.55988376
60Regulation of autophagy_Homo sapiens_hsa041400.55796449
61Salmonella infection_Homo sapiens_hsa051320.55219426
62NOD-like receptor signaling pathway_Homo sapiens_hsa046210.54776708
63Alzheimers disease_Homo sapiens_hsa050100.54345450
64Pertussis_Homo sapiens_hsa051330.54224672
65Sphingolipid signaling pathway_Homo sapiens_hsa040710.54110309
66Spliceosome_Homo sapiens_hsa030400.53337615
67Platelet activation_Homo sapiens_hsa046110.52042735
68Influenza A_Homo sapiens_hsa051640.46706667
69Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.41676711
70Leukocyte transendothelial migration_Homo sapiens_hsa046700.41075377
71Hepatitis C_Homo sapiens_hsa051600.40846707
72Pancreatic cancer_Homo sapiens_hsa052120.40296697
73Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.40101196
74Insulin resistance_Homo sapiens_hsa049310.40021082
75Transcriptional misregulation in cancer_Homo sapiens_hsa052020.36527140
76African trypanosomiasis_Homo sapiens_hsa051430.35723688
77Galactose metabolism_Homo sapiens_hsa000520.34309103
78Basal transcription factors_Homo sapiens_hsa030220.32153079
79FoxO signaling pathway_Homo sapiens_hsa040680.31776510
80AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.31508111
81One carbon pool by folate_Homo sapiens_hsa006700.31418169
82Prolactin signaling pathway_Homo sapiens_hsa049170.31175406
83Linoleic acid metabolism_Homo sapiens_hsa005910.30993392
84Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.30607502
85Endocytosis_Homo sapiens_hsa041440.28878473
86HIF-1 signaling pathway_Homo sapiens_hsa040660.28475004
87Steroid hormone biosynthesis_Homo sapiens_hsa001400.27522113
88Phagosome_Homo sapiens_hsa041450.25538914
89Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.24981341
90Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.24780677
91Sulfur metabolism_Homo sapiens_hsa009200.22732163
92Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.21750102
93Ras signaling pathway_Homo sapiens_hsa040140.21516060
94MAPK signaling pathway_Homo sapiens_hsa040100.21093280
95Huntingtons disease_Homo sapiens_hsa050160.18981588
96Drug metabolism - other enzymes_Homo sapiens_hsa009830.18919664
97Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.18340437
98RNA degradation_Homo sapiens_hsa030180.17430597
99ABC transporters_Homo sapiens_hsa020100.16648501
100Aldosterone synthesis and secretion_Homo sapiens_hsa049250.16340459

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