TRBV6-5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative T cell selection (GO:0043383)7.52157533
2negative thymic T cell selection (GO:0045060)7.15078124
3positive regulation of gamma-delta T cell activation (GO:0046645)6.58500213
4positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)6.46157246
5antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.31256481
6antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.84902802
7negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.74562064
8negative regulation of cell killing (GO:0031342)5.74562064
9thymic T cell selection (GO:0045061)5.70055985
10regulation of regulatory T cell differentiation (GO:0045589)5.49346908
11positive regulation of interleukin-2 biosynthetic process (GO:0045086)5.47459995
12regulation of gamma-delta T cell differentiation (GO:0045586)5.46703699
13antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.41152244
14Arp2/3 complex-mediated actin nucleation (GO:0034314)5.36568405
15T cell selection (GO:0045058)5.26453204
16antigen processing and presentation of endogenous antigen (GO:0019883)5.26417972
17positive T cell selection (GO:0043368)5.24782883
18T cell migration (GO:0072678)5.16124125
19positive thymic T cell selection (GO:0045059)5.08223567
20cellular response to interleukin-15 (GO:0071350)5.06733235
21response to interleukin-15 (GO:0070672)5.02876522
22tolerance induction (GO:0002507)4.95622320
23regulation of T cell tolerance induction (GO:0002664)4.92770571
24regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.89763054
25regulation of gamma-delta T cell activation (GO:0046643)4.89193011
26regulation of B cell receptor signaling pathway (GO:0050855)4.87401923
27regulation of isotype switching to IgG isotypes (GO:0048302)4.82270473
28positive regulation of B cell differentiation (GO:0045579)4.62326712
29regulation of interleukin-5 production (GO:0032674)4.58574107
30positive regulation of tolerance induction (GO:0002645)4.57600832
31cytidine metabolic process (GO:0046087)4.53680458
32cytidine catabolic process (GO:0006216)4.53680458
33cytidine deamination (GO:0009972)4.53680458
34actin nucleation (GO:0045010)4.51235451
35regulation of alpha-beta T cell proliferation (GO:0046640)4.45085093
36DNA deamination (GO:0045006)4.43452081
37T cell receptor signaling pathway (GO:0050852)4.41811094
38leukocyte aggregation (GO:0070486)4.41245100
39regulation of interleukin-2 biosynthetic process (GO:0045076)4.30793083
40positive regulation of alpha-beta T cell proliferation (GO:0046641)4.27550671
41mast cell activation (GO:0045576)4.20187984
42regulation of tolerance induction (GO:0002643)4.11685052
43pyrimidine ribonucleoside catabolic process (GO:0046133)4.08303434
44regulation of natural killer cell mediated immunity (GO:0002715)4.04097066
45regulation of natural killer cell mediated cytotoxicity (GO:0042269)4.04097066
46negative regulation of T cell mediated immunity (GO:0002710)4.01107683
47regulation of B cell differentiation (GO:0045577)3.98557529
48positive regulation of T cell mediated cytotoxicity (GO:0001916)3.93027550
49antigen receptor-mediated signaling pathway (GO:0050851)3.92865788
50positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.91690242
51positive regulation of natural killer cell mediated immunity (GO:0002717)3.87075964
52negative regulation of stress fiber assembly (GO:0051497)3.83018591
53positive regulation of granulocyte differentiation (GO:0030854)3.82401636
54regulation of T cell mediated cytotoxicity (GO:0001914)3.79299011
55regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.72498847
56regulation of leukocyte mediated cytotoxicity (GO:0001910)3.69225571
57positive regulation of interleukin-4 production (GO:0032753)3.66431476
58negative regulation of lymphocyte mediated immunity (GO:0002707)3.62026955
59mast cell activation involved in immune response (GO:0002279)3.61000436
60mast cell degranulation (GO:0043303)3.61000436
61negative regulation of T cell apoptotic process (GO:0070233)3.60568342
62positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.52277030
63positive regulation of cell killing (GO:0031343)3.51274722
64antigen processing and presentation via MHC class Ib (GO:0002475)3.49312618
65positive regulation of calcium-mediated signaling (GO:0050850)3.47898144
66positive regulation of interleukin-2 production (GO:0032743)3.43405530
67positive regulation of humoral immune response (GO:0002922)3.39940958
68regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.38102011
69positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.37410781
70lymphocyte migration (GO:0072676)3.36528831
71regulation of T cell receptor signaling pathway (GO:0050856)3.34869546
72regulation of cell killing (GO:0031341)3.33874154
73regulation of defense response to virus by virus (GO:0050690)3.33191318
74type I interferon signaling pathway (GO:0060337)3.32771070
75cellular response to type I interferon (GO:0071357)3.32771070
76T cell homeostasis (GO:0043029)3.31633049
77positive regulation of T cell mediated immunity (GO:0002711)3.30256105
78response to type I interferon (GO:0034340)3.27954078
79positive regulation of isotype switching (GO:0045830)3.26859596
80T cell costimulation (GO:0031295)3.23699292
81lymphocyte costimulation (GO:0031294)3.19787454
82respiratory burst (GO:0045730)3.19717441
83activated T cell proliferation (GO:0050798)3.16765771
84regulation of interleukin-4 production (GO:0032673)3.15507881
85positive regulation of lymphocyte mediated immunity (GO:0002708)3.15271301
86negative regulation of leukocyte mediated immunity (GO:0002704)3.14158431
87T cell differentiation (GO:0030217)3.13913493
88immunoglobulin mediated immune response (GO:0016064)3.09308381
89regulation of alpha-beta T cell activation (GO:0046634)3.08069881
90leukocyte degranulation (GO:0043299)3.07914187
91interferon-gamma production (GO:0032609)3.03682340
92regulation of T cell mediated immunity (GO:0002709)3.03500210
93positive regulation of alpha-beta T cell activation (GO:0046635)3.02192800
94NIK/NF-kappaB signaling (GO:0038061)3.01687733
95T cell activation (GO:0042110)3.01196804
96negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.00766898
97B cell mediated immunity (GO:0019724)3.00520491
98dendritic cell chemotaxis (GO:0002407)2.97414848
99positive regulation of DNA recombination (GO:0045911)2.96510835
100alpha-beta T cell differentiation (GO:0046632)2.96350456

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_20620947_ChIP-Seq_CD4_POS_T_Human6.21838930
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.52936832
3IRF8_22096565_ChIP-ChIP_GC-B_Human5.25670496
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.23203896
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.79478702
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.77299215
7IRF8_21731497_ChIP-ChIP_J774_Mouse3.76896460
8ELF1_17652178_ChIP-ChIP_JURKAT_Human3.71791321
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.69440081
10RUNX_20019798_ChIP-Seq_JUKART_Human3.63201859
11MYB_26560356_Chip-Seq_TH2_Human3.57511685
12SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.08741687
13STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.02500618
14MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.94709992
15STAT4_19710469_ChIP-ChIP_TH1__Mouse2.84147306
16RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.81859370
17MAF_26560356_Chip-Seq_TH1_Human2.76753607
18UTX_26944678_Chip-Seq_JUKART_Human2.75862753
19MYB_26560356_Chip-Seq_TH1_Human2.62968856
20FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.60558315
21GATA3_27048872_Chip-Seq_THYMUS_Human2.41040688
22MAF_26560356_Chip-Seq_TH2_Human2.32716650
23SPI1_23547873_ChIP-Seq_NB4_Human2.19210113
24SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.16652438
25GATA3_26560356_Chip-Seq_TH2_Human2.15474083
26FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.12945821
27MYC_22102868_ChIP-Seq_BL_Human2.04582889
28E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.97853637
29NOTCH1_21737748_ChIP-Seq_TLL_Human1.90978176
30IRF8_27001747_Chip-Seq_BMDM_Mouse1.83741141
31LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.83016864
32MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.82534956
33SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.81133587
34RUNX1_22412390_ChIP-Seq_EML_Mouse1.75039509
35NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.71423808
36VDR_23849224_ChIP-Seq_CD4+_Human1.70834210
37MYB_21317192_ChIP-Seq_ERMYB_Mouse1.58567515
38CIITA_25753668_ChIP-Seq_RAJI_Human1.54055406
39RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.49996021
40SPI1_23127762_ChIP-Seq_K562_Human1.43394893
41VDR_24763502_ChIP-Seq_THP-1_Human1.42355279
42TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.41869820
43SCL_19346495_ChIP-Seq_HPC-7_Human1.40917137
44BRD4_27068464_Chip-Seq_AML-cells_Mouse1.40616552
45FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.39681501
46VDR_21846776_ChIP-Seq_THP-1_Human1.38086615
47LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.37678363
48FOXP3_21729870_ChIP-Seq_TREG_Human1.34621734
49HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.33453910
50GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.31342600
51SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.27100176
52NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.26661089
53RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.22221285
54SMAD_19615063_ChIP-ChIP_OVARY_Human1.17041872
55GABP_17652178_ChIP-ChIP_JURKAT_Human1.16407090
56CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.13181872
57HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.11215721
58CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.09510512
59BCL6_27268052_Chip-Seq_Bcells_Human1.09345993
60FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09321161
61ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.07383234
62HOXB4_20404135_ChIP-ChIP_EML_Mouse1.07110218
63CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04279541
64KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.04065865
65TCF7_22412390_ChIP-Seq_EML_Mouse1.01447604
66CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.01245323
67CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99602678
68EST1_17652178_ChIP-ChIP_JURKAT_Human0.99341208
69P300_27268052_Chip-Seq_Bcells_Human0.99242144
70CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.98737845
71SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95775487
72EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.95207034
73EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.90456304
74GATA2_22383799_ChIP-Seq_G1ME_Mouse0.89904520
75RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.89148009
76E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.87146269
77BCOR_27268052_Chip-Seq_Bcells_Human0.87130804
78SRF_21415370_ChIP-Seq_HL-1_Mouse0.85136649
79TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.84996900
80PU_27001747_Chip-Seq_BMDM_Mouse0.83956303
81KDM2B_26808549_Chip-Seq_DND41_Human0.83313860
82GATA3_26560356_Chip-Seq_TH1_Human0.82271326
83ELF1_20517297_ChIP-Seq_JURKAT_Human0.81875376
84KDM2B_26808549_Chip-Seq_JURKAT_Human0.80879628
85TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.80667643
86SPI1_20517297_ChIP-Seq_HL60_Human0.80538430
87CTCF_27219007_Chip-Seq_ERYTHROID_Human0.80107997
88PU.1_20513432_ChIP-Seq_Bcells_Mouse0.80007424
89NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.78630535
90KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.78511027
91PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.77983164
92PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.76296035
93JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.75593399
94RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.75479891
95TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.75462653
96KDM2B_26808549_Chip-Seq_SUP-B15_Human0.75053586
97GATA1_19941827_ChIP-Seq_MEL_Mouse0.74747951
98PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.73747501
99RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73187390
100PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.72851639

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to5.41432360
2MP0003763_abnormal_thymus_physiology4.65531326
3MP0001835_abnormal_antigen_presentation3.80646637
4MP0009333_abnormal_splenocyte_physiolog3.20887641
5MP0001800_abnormal_humoral_immune3.14474394
6MP0005000_abnormal_immune_tolerance3.10058957
7MP0003436_decreased_susceptibility_to3.08390100
8MP0003724_increased_susceptibility_to3.04532318
9MP0000685_abnormal_immune_system3.02434862
10MP0005387_immune_system_phenotype3.02146117
11MP0001790_abnormal_immune_system3.02146117
12MP0009785_altered_susceptibility_to2.89261402
13MP0005025_abnormal_response_to2.87278425
14MP0002166_altered_tumor_susceptibility2.84546440
15MP0002723_abnormal_immune_serum2.77680475
16MP0002420_abnormal_adaptive_immunity2.73909025
17MP0001819_abnormal_immune_cell2.69021276
18MP0003866_abnormal_defecation2.63405829
19MP0002148_abnormal_hypersensitivity_rea2.53742768
20MP0001873_stomach_inflammation2.48222031
21MP0002452_abnormal_antigen_presenting2.46250924
22MP0002398_abnormal_bone_marrow2.40451862
23MP0000703_abnormal_thymus_morphology2.34444081
24MP0002405_respiratory_system_inflammati2.33182226
25MP0000716_abnormal_immune_system2.27683516
26MP0010155_abnormal_intestine_physiology2.19043824
27MP0002419_abnormal_innate_immunity2.17554742
28MP0004381_abnormal_hair_follicle2.08888414
29MP0005464_abnormal_platelet_physiology2.06871586
30MP0004947_skin_inflammation2.03838689
31MP0002006_tumorigenesis2.03224012
32MP0000689_abnormal_spleen_morphology1.98735561
33MP0002277_abnormal_respiratory_mucosa1.96195207
34MP0002722_abnormal_immune_system1.95471649
35MP0005075_abnormal_melanosome_morpholog1.95326091
36MP0001845_abnormal_inflammatory_respons1.88528556
37MP0006082_CNS_inflammation1.88068380
38MP0002429_abnormal_blood_cell1.77940527
39MP0001348_abnormal_lacrimal_gland1.58588879
40MP0000465_gastrointestinal_hemorrhage1.55143415
41MP0002138_abnormal_hepatobiliary_system1.53041450
42MP0001533_abnormal_skeleton_physiology1.46109387
43MP0005379_endocrine/exocrine_gland_phen1.39605034
44MP0003300_gastrointestinal_ulcer1.39343790
45MP0002163_abnormal_gland_morphology1.32396084
46MP0003303_peritoneal_inflammation1.27468267
47MP0000490_abnormal_crypts_of1.21629928
48MP0002933_joint_inflammation1.21587005
49MP0005645_abnormal_hypothalamus_physiol1.21074165
50MP0008469_abnormal_protein_level1.20741427
51MP0003045_fibrosis1.20075289
52MP0005310_abnormal_salivary_gland1.19084909
53MP0001853_heart_inflammation1.17686680
54MP0002132_abnormal_respiratory_system1.15534379
55MP0009764_decreased_sensitivity_to1.12368299
56MP0004510_myositis1.10538852
57MP0002254_reproductive_system_inflammat1.03399438
58MP0003786_premature_aging1.00233343
59MP0002396_abnormal_hematopoietic_system0.86846175
60MP0003806_abnormal_nucleotide_metabolis0.85311353
61MP0002019_abnormal_tumor_incidence0.85110018
62MP0001851_eye_inflammation0.80773094
63MP0002009_preneoplasia0.80527568
64MP0001663_abnormal_digestive_system0.77911126
65MP0009763_increased_sensitivity_to0.77908925
66MP0003448_altered_tumor_morphology0.74912611
67MP0005584_abnormal_enzyme/coenzyme_acti0.73615970
68MP0001243_abnormal_dermal_layer0.73240304
69MP0002693_abnormal_pancreas_physiology0.72670426
70MP0000015_abnormal_ear_pigmentation0.71475504
71MP0001919_abnormal_reproductive_system0.70882141
72MP0004130_abnormal_muscle_cell0.69693670
73MP0003172_abnormal_lysosome_physiology0.69117420
74MP0002998_abnormal_bone_remodeling0.68658251
75MP0003646_muscle_fatigue0.68281264
76MP0000858_altered_metastatic_potential0.67774459
77MP0009278_abnormal_bone_marrow0.63479441
78MP0005166_decreased_susceptibility_to0.61999897
79MP0001986_abnormal_taste_sensitivity0.58407851
80MP0001765_abnormal_ion_homeostasis0.58101078
81MP0008995_early_reproductive_senescence0.57695315
82MP0009840_abnormal_foam_cell0.55470385
83MP0000604_amyloidosis0.51690190
84MP0005390_skeleton_phenotype0.51636218
85MP0000477_abnormal_intestine_morphology0.48279813
86MP0008873_increased_physiological_sensi0.47794546
87MP0008961_abnormal_basal_metabolism0.46947696
88MP0003795_abnormal_bone_structure0.46515217
89MP0003075_altered_response_to0.43778351
90MP0002095_abnormal_skin_pigmentation0.43377676
91MP0003191_abnormal_cellular_cholesterol0.41899520
92MP0005381_digestive/alimentary_phenotyp0.40651349
93MP0009642_abnormal_blood_homeostasis0.40470396
94MP0002136_abnormal_kidney_physiology0.40147060
95MP0008260_abnormal_autophagy0.40029712
96MP0005535_abnormal_body_temperature0.37725042
97MP0005360_urolithiasis0.37712575
98MP0000609_abnormal_liver_physiology0.37125880
99MP0009643_abnormal_urine_homeostasis0.34128957
100MP0008872_abnormal_physiological_respon0.33518784

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)6.55852555
2Elevated erythrocyte sedimentation rate (HP:0003565)6.27299284
3Abnormality of T cell number (HP:0011839)6.25566589
4Autoimmune hemolytic anemia (HP:0001890)6.04890956
5Stomatitis (HP:0010280)5.72796943
6Abnormality of T cells (HP:0002843)5.21367137
7Abnormal delayed hypersensitivity skin test (HP:0002963)5.04536399
8Myositis (HP:0100614)5.01233716
9Severe combined immunodeficiency (HP:0004430)5.00683881
10IgM deficiency (HP:0002850)4.84169819
11IgG deficiency (HP:0004315)4.62441900
12Increased IgM level (HP:0003496)4.42504316
13Eczematoid dermatitis (HP:0000976)4.28007461
14Abnormality of T cell physiology (HP:0011840)4.25389098
15Recurrent viral infections (HP:0004429)4.06464064
16Recurrent fungal infections (HP:0002841)3.94798712
17Combined immunodeficiency (HP:0005387)3.93002766
18Aplastic anemia (HP:0001915)3.92557332
19Recurrent abscess formation (HP:0002722)3.85617319
20Panhypogammaglobulinemia (HP:0003139)3.84863982
21Recurrent bacterial skin infections (HP:0005406)3.79754639
22Encephalitis (HP:0002383)3.72983615
23Abnormality of eosinophils (HP:0001879)3.72950092
24Pustule (HP:0200039)3.71714347
25Abnormality of macrophages (HP:0004311)3.67048930
26Eosinophilia (HP:0001880)3.62377034
27Granulocytopenia (HP:0001913)3.61632213
28Lymphopenia (HP:0001888)3.56549380
29Leukocytosis (HP:0001974)3.50793868
30Autoimmune thrombocytopenia (HP:0001973)3.46778357
31Meningitis (HP:0001287)3.40759034
32Abnormality of cells of the lymphoid lineage (HP:0012140)3.40288831
33Chronic obstructive pulmonary disease (HP:0006510)3.27113219
34Obstructive lung disease (HP:0006536)3.27113219
35Hypergammaglobulinemia (HP:0010702)3.17553065
36Retrobulbar optic neuritis (HP:0100654)3.14287823
37Optic neuritis (HP:0100653)3.14287823
38Mediastinal lymphadenopathy (HP:0100721)3.12659944
39Orchitis (HP:0100796)3.10811980
40Pulmonary infiltrates (HP:0002113)3.09202131
41Gastrointestinal infarctions (HP:0005244)3.09008537
42Vasculitis (HP:0002633)3.07381048
43Increased IgE level (HP:0003212)3.06213246
44Chronic diarrhea (HP:0002028)3.01695306
45Recurrent skin infections (HP:0001581)2.97332290
46Chronic mucocutaneous candidiasis (HP:0002728)2.96404482
47Recurrent cutaneous fungal infections (HP:0011370)2.96404482
48Spontaneous hematomas (HP:0007420)2.92650722
49Hypoproteinemia (HP:0003075)2.87303730
50Purpura (HP:0000979)2.84428240
51Thyroiditis (HP:0100646)2.83950364
52Recurrent bronchitis (HP:0002837)2.72243558
53Chest pain (HP:0100749)2.66142638
54Petechiae (HP:0000967)2.65066785
55Lymphoma (HP:0002665)2.62486959
56Slow saccadic eye movements (HP:0000514)2.61515143
57Joint swelling (HP:0001386)2.52063962
58Prolonged bleeding time (HP:0003010)2.49120167
59Hemoptysis (HP:0002105)2.45929218
60Abnormality of B cell number (HP:0010975)2.45745313
61Hypochromic anemia (HP:0001931)2.38542104
62Inflammation of the large intestine (HP:0002037)2.35093295
63Keratoconjunctivitis sicca (HP:0001097)2.33049541
64Verrucae (HP:0200043)2.27585868
65Papilloma (HP:0012740)2.27585868
66Urticaria (HP:0001025)2.25450498
67Epistaxis (HP:0000421)2.22882002
68Thrombocytosis (HP:0001894)2.22213218
69Microcytic anemia (HP:0001935)2.20669685
70Agammaglobulinemia (HP:0004432)2.18377829
71Muscle fiber atrophy (HP:0100295)2.18312443
72Gastrointestinal inflammation (HP:0004386)2.17894706
73Gingival bleeding (HP:0000225)2.17005642
74Acute hepatic failure (HP:0006554)2.13931612
75Keratoconjunctivitis (HP:0001096)2.13229125
76Anorexia (HP:0002039)2.11670970
77Abnormality of the prostate (HP:0008775)2.05848007
78B lymphocytopenia (HP:0010976)2.03497294
79Skin rash (HP:0000988)2.00971820
80Increased intramyocellular lipid droplets (HP:0012240)2.00409210
81Pulmonary embolism (HP:0002204)2.00396864
82Type 2 muscle fiber atrophy (HP:0003554)1.99911240
83Chronic otitis media (HP:0000389)1.96857532
84Oligomenorrhea (HP:0000876)1.94369547
85Hypoplasia of the thymus (HP:0000778)1.93700223
86Gangrene (HP:0100758)1.89234754
87Hemiplegia (HP:0002301)1.88967161
88Bronchitis (HP:0012387)1.86508676
89Aplasia/Hypoplasia of the thymus (HP:0010515)1.86223387
90Recurrent gram-negative bacterial infections (HP:0005420)1.82658431
91Hypochromic microcytic anemia (HP:0004840)1.81705009
92Increased muscle lipid content (HP:0009058)1.78484329
93Acne (HP:0001061)1.78359316
94Amaurosis fugax (HP:0100576)1.75638537
95Pancytopenia (HP:0001876)1.73346922
96Sepsis (HP:0100806)1.72988763
97Absent rod-and cone-mediated responses on ERG (HP:0007688)1.72655769
98Abnormality of the pleura (HP:0002103)1.70987985
99Arterial thrombosis (HP:0004420)1.69914978
100Arthralgia (HP:0002829)1.68211892

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK25.17906299
2TXK4.88594994
3MAP4K14.11855715
4LATS13.44597350
5KDR3.12968547
6ITK2.76425397
7NUAK12.74837039
8ZAP702.71912628
9MST42.68769927
10SCYL22.62210270
11FES2.26625758
12PASK2.17964976
13TNK22.07746198
14GRK62.05672314
15RIPK41.97635288
16BTK1.89302392
17CSK1.77491356
18IKBKE1.75030464
19LCK1.73049375
20TESK11.72696321
21TAOK31.71495295
22SYK1.69597411
23MAP2K31.55641773
24IRAK41.53171579
25TAOK21.53125697
26BUB11.46421802
27TYK21.45703528
28MAP3K111.42450557
29PLK41.40940687
30NLK1.40341899
31TBK11.37717370
32TEC1.36502960
33TLK11.32566617
34JAK31.32349752
35MAP4K21.28038706
36CAMKK21.26834543
37HCK1.26163080
38CAMKK11.24919611
39ZAK1.24334413
40TAOK11.23793590
41CLK11.23779154
42MAP3K31.22992108
43JAK11.19939975
44MAP3K121.13346054
45IKBKB1.08403342
46VRK11.07667816
47PIK3CG1.07525874
48VRK21.03834572
49LYN1.03333052
50PRKCQ0.96901534
51PRPF4B0.78924842
52BLK0.76823312
53EPHB10.66819787
54PIM10.65756005
55LIMK10.63252971
56ADRBK20.57559425
57CSF1R0.57093585
58JAK20.54604176
59FYN0.54296957
60MUSK0.53192376
61MAPK110.52136959
62FGFR40.50092895
63YES10.48796634
64SIK30.48547729
65KIT0.48473399
66MAP3K140.47296952
67SMG10.45975137
68LRRK20.45933674
69MAP3K100.45815373
70RPS6KA50.44123285
71PDGFRB0.42893530
72STK100.42792923
73MAPK120.40093210
74FGR0.39793327
75BMPR20.37948106
76PRKCH0.36605970
77PDK10.35433955
78MAP2K60.34708604
79IGF1R0.33166954
80GRK70.32904638
81MARK30.32475889
82RPS6KA40.30888324
83DYRK1B0.29499797
84NEK60.29396913
85MAP3K50.29249374
86MAP3K130.28036827
87TRPM70.27735908
88PTK60.27092870
89HIPK20.25633987
90EPHA30.20980398
91ERN10.20568220
92MAP3K10.20367259
93WNK40.20106077
94TYRO30.19132207
95FGFR30.19079821
96CDK40.18976653
97GRK50.18973006
98DAPK10.16494870
99PRKCD0.16226601
100IRAK10.16197292

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053406.13375822
2T cell receptor signaling pathway_Homo sapiens_hsa046603.84883818
3Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046503.25554079
4Graft-versus-host disease_Homo sapiens_hsa053323.23779264
5Antigen processing and presentation_Homo sapiens_hsa046123.20016846
6Autoimmune thyroid disease_Homo sapiens_hsa053203.14347264
7Allograft rejection_Homo sapiens_hsa053303.11362529
8Measles_Homo sapiens_hsa051622.72389179
9Hematopoietic cell lineage_Homo sapiens_hsa046402.64660922
10Asthma_Homo sapiens_hsa053102.43679733
11Type I diabetes mellitus_Homo sapiens_hsa049402.35091332
12Proteasome_Homo sapiens_hsa030502.34043188
13NF-kappa B signaling pathway_Homo sapiens_hsa040642.21310427
14Osteoclast differentiation_Homo sapiens_hsa043801.95280337
15Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.94905238
16Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.90744793
17Viral myocarditis_Homo sapiens_hsa054161.80779960
18RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.78190496
19Jak-STAT signaling pathway_Homo sapiens_hsa046301.67761582
20Intestinal immune network for IgA production_Homo sapiens_hsa046721.66708679
21Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.62629599
22B cell receptor signaling pathway_Homo sapiens_hsa046621.47574344
23Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.43755235
24Herpes simplex infection_Homo sapiens_hsa051681.41056480
25Shigellosis_Homo sapiens_hsa051311.38318716
26Chemokine signaling pathway_Homo sapiens_hsa040621.32585612
27NOD-like receptor signaling pathway_Homo sapiens_hsa046211.30913473
28Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.26440136
29Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.26025669
30Toll-like receptor signaling pathway_Homo sapiens_hsa046201.25008435
31Malaria_Homo sapiens_hsa051441.22756125
32Leishmaniasis_Homo sapiens_hsa051401.22296056
33Ribosome_Homo sapiens_hsa030101.16130427
34Staphylococcus aureus infection_Homo sapiens_hsa051501.10746539
35Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.10002620
36Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.08512838
37TNF signaling pathway_Homo sapiens_hsa046681.02001913
38Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.00993209
39Acute myeloid leukemia_Homo sapiens_hsa052210.94580547
40Platelet activation_Homo sapiens_hsa046110.93334791
41Tuberculosis_Homo sapiens_hsa051520.90729671
42Influenza A_Homo sapiens_hsa051640.89681243
43Epstein-Barr virus infection_Homo sapiens_hsa051690.85664685
44Salmonella infection_Homo sapiens_hsa051320.84324051
45SNARE interactions in vesicular transport_Homo sapiens_hsa041300.83915901
46Rheumatoid arthritis_Homo sapiens_hsa053230.83849162
47Leukocyte transendothelial migration_Homo sapiens_hsa046700.82320412
48HTLV-I infection_Homo sapiens_hsa051660.79777784
49Apoptosis_Homo sapiens_hsa042100.77689463
50Parkinsons disease_Homo sapiens_hsa050120.77443756
51Toxoplasmosis_Homo sapiens_hsa051450.74540127
52Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.71409758
53Hepatitis B_Homo sapiens_hsa051610.69830743
54Legionellosis_Homo sapiens_hsa051340.69233590
55Regulation of autophagy_Homo sapiens_hsa041400.65846872
56Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.62961717
57Viral carcinogenesis_Homo sapiens_hsa052030.61432612
58Oxidative phosphorylation_Homo sapiens_hsa001900.60876831
59Endocytosis_Homo sapiens_hsa041440.58267160
60Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.57441738
61Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.55784815
62VEGF signaling pathway_Homo sapiens_hsa043700.55109140
63African trypanosomiasis_Homo sapiens_hsa051430.54447261
64Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.53595500
65RNA polymerase_Homo sapiens_hsa030200.52739091
66Non-small cell lung cancer_Homo sapiens_hsa052230.51416110
67Pertussis_Homo sapiens_hsa051330.50313727
68alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.50045250
69Hepatitis C_Homo sapiens_hsa051600.44739462
70Phosphatidylinositol signaling system_Homo sapiens_hsa040700.42493444
71Pancreatic cancer_Homo sapiens_hsa052120.38266703
72Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.35707189
73Alzheimers disease_Homo sapiens_hsa050100.35607167
74Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.27426099
75Systemic lupus erythematosus_Homo sapiens_hsa053220.26814762
76Ras signaling pathway_Homo sapiens_hsa040140.26275472
77Peroxisome_Homo sapiens_hsa041460.26178104
78Spliceosome_Homo sapiens_hsa030400.25490409
79MAPK signaling pathway_Homo sapiens_hsa040100.24268148
80Rap1 signaling pathway_Homo sapiens_hsa040150.23274807
81RNA degradation_Homo sapiens_hsa030180.23150957
82Colorectal cancer_Homo sapiens_hsa052100.22631129
83Inositol phosphate metabolism_Homo sapiens_hsa005620.22179113
84Prolactin signaling pathway_Homo sapiens_hsa049170.21877924
85Transcriptional misregulation in cancer_Homo sapiens_hsa052020.20840032
86Phagosome_Homo sapiens_hsa041450.20180644
87Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.19335116
88Sphingolipid signaling pathway_Homo sapiens_hsa040710.17891390
89Regulation of actin cytoskeleton_Homo sapiens_hsa048100.17370104
90Caffeine metabolism_Homo sapiens_hsa002320.16848909
91Glycerophospholipid metabolism_Homo sapiens_hsa005640.12046650
92FoxO signaling pathway_Homo sapiens_hsa040680.10600853
93HIF-1 signaling pathway_Homo sapiens_hsa040660.10547013
94Olfactory transduction_Homo sapiens_hsa047400.10450252
95Carbohydrate digestion and absorption_Homo sapiens_hsa049730.09332059
96Linoleic acid metabolism_Homo sapiens_hsa005910.08785791
97Huntingtons disease_Homo sapiens_hsa050160.07866098
98Pentose phosphate pathway_Homo sapiens_hsa000300.04605640
99Cyanoamino acid metabolism_Homo sapiens_hsa004600.04062833
100Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.03828741

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