TRBV7-2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative T cell selection (GO:0043383)7.36475299
2negative thymic T cell selection (GO:0045060)6.91567638
3antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.60072096
4tolerance induction (GO:0002507)6.41265068
5antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.20440759
6positive regulation of gamma-delta T cell activation (GO:0046645)6.06921506
7positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)6.04148130
8negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.99795160
9negative regulation of cell killing (GO:0031342)5.99795160
10antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.79357903
11regulation of isotype switching to IgG isotypes (GO:0048302)5.68191252
12thymic T cell selection (GO:0045061)5.63030149
13antigen processing and presentation of endogenous antigen (GO:0019883)5.52674098
14positive T cell selection (GO:0043368)5.49431258
15regulation of T cell tolerance induction (GO:0002664)5.38751482
16regulation of gamma-delta T cell differentiation (GO:0045586)5.37986747
17positive regulation of interleukin-2 biosynthetic process (GO:0045086)5.37016518
18T cell selection (GO:0045058)5.33739972
19cellular response to interleukin-15 (GO:0071350)5.25723251
20regulation of regulatory T cell differentiation (GO:0045589)5.21153962
21positive regulation of granulocyte differentiation (GO:0030854)5.20040173
22response to interleukin-15 (GO:0070672)5.15139024
23positive regulation of tolerance induction (GO:0002645)5.05513100
24positive thymic T cell selection (GO:0045059)5.02761837
25regulation of gamma-delta T cell activation (GO:0046643)4.87597906
26leukocyte aggregation (GO:0070486)4.83330347
27regulation of B cell receptor signaling pathway (GO:0050855)4.81551723
28activated T cell proliferation (GO:0050798)4.80295729
29regulation of tolerance induction (GO:0002643)4.56055889
30NIK/NF-kappaB signaling (GO:0038061)4.48883684
31regulation of interleukin-2 biosynthetic process (GO:0045076)4.42745760
32T cell migration (GO:0072678)4.35583733
33regulation of alpha-beta T cell proliferation (GO:0046640)4.28115450
34positive regulation of T cell differentiation in thymus (GO:0033089)4.25417289
35regulation of natural killer cell mediated cytotoxicity (GO:0042269)4.24089282
36regulation of natural killer cell mediated immunity (GO:0002715)4.24089282
37negative regulation of T cell mediated immunity (GO:0002710)4.19643717
38T cell receptor signaling pathway (GO:0050852)4.12602924
39positive regulation of alpha-beta T cell proliferation (GO:0046641)4.04553776
40alpha-beta T cell differentiation (GO:0046632)3.97650459
41positive regulation of natural killer cell mediated immunity (GO:0002717)3.91225012
42negative regulation of lymphocyte mediated immunity (GO:0002707)3.88943150
43interferon-gamma production (GO:0032609)3.88937151
44antigen receptor-mediated signaling pathway (GO:0050851)3.76245881
45positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.76212742
46positive regulation of interleukin-4 production (GO:0032753)3.75019068
47regulation of T cell mediated cytotoxicity (GO:0001914)3.72028554
48regulation of leukocyte mediated cytotoxicity (GO:0001910)3.70374646
49mast cell activation (GO:0045576)3.67003810
50antigen processing and presentation via MHC class Ib (GO:0002475)3.65710857
51positive regulation of isotype switching (GO:0045830)3.65639944
52positive regulation of T cell mediated cytotoxicity (GO:0001916)3.65125776
53T cell homeostasis (GO:0043029)3.57228212
54positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.55991985
55alpha-beta T cell activation (GO:0046631)3.54943079
56positive regulation of cell killing (GO:0031343)3.52158849
57lymphocyte costimulation (GO:0031294)3.52115538
58regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.51387185
59regulation of granulocyte differentiation (GO:0030852)3.49143976
60T cell costimulation (GO:0031295)3.48101258
61regulation of cell killing (GO:0031341)3.46125638
62regulation of chronic inflammatory response (GO:0002676)3.46124457
63CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.42930249
64T-helper cell differentiation (GO:0042093)3.42930249
65regulation of interleukin-4 production (GO:0032673)3.39446117
66Arp2/3 complex-mediated actin nucleation (GO:0034314)3.37322107
67positive regulation of DNA recombination (GO:0045911)3.36396716
68negative regulation of leukocyte mediated immunity (GO:0002704)3.32815480
69alpha-beta T cell differentiation involved in immune response (GO:0002293)3.31803386
70alpha-beta T cell activation involved in immune response (GO:0002287)3.31803386
71T cell differentiation involved in immune response (GO:0002292)3.31803386
72positive regulation of interleukin-2 production (GO:0032743)3.31678057
73CD4-positive, alpha-beta T cell differentiation (GO:0043367)3.31486463
74T cell differentiation (GO:0030217)3.31379085
75cytidine metabolic process (GO:0046087)3.30204334
76cytidine catabolic process (GO:0006216)3.30204334
77cytidine deamination (GO:0009972)3.30204334
78regulation of B cell differentiation (GO:0045577)3.29686340
79positive regulation of B cell differentiation (GO:0045579)3.28601649
80regulation of defense response to virus by virus (GO:0050690)3.28327054
81regulation of isotype switching (GO:0045191)3.25600710
82negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.23456646
83signal complex assembly (GO:0007172)3.19501835
84regulation of alpha-beta T cell activation (GO:0046634)3.17141967
85cellular response to type I interferon (GO:0071357)3.15047060
86type I interferon signaling pathway (GO:0060337)3.15047060
87negative regulation of interleukin-12 production (GO:0032695)3.13720088
88response to type I interferon (GO:0034340)3.13226315
89positive regulation of lymphocyte mediated immunity (GO:0002708)3.12838558
90negative regulation of T cell apoptotic process (GO:0070233)3.09121991
91regulation of T cell receptor signaling pathway (GO:0050856)3.06749987
92positive regulation of B cell mediated immunity (GO:0002714)3.04167802
93positive regulation of immunoglobulin mediated immune response (GO:0002891)3.04167802
94negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.03776018
95regulation of thymocyte apoptotic process (GO:0070243)3.03664429
96pyrimidine ribonucleoside catabolic process (GO:0046133)3.03480445
97CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.03440810
98B cell receptor signaling pathway (GO:0050853)3.02845382
99myeloid dendritic cell differentiation (GO:0043011)3.02779073
100regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.02196773

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse7.03199359
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human6.64939988
3IRF8_22096565_ChIP-ChIP_GC-B_Human5.07867316
4RUNX_20019798_ChIP-Seq_JUKART_Human3.97547973
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.94459339
6MYB_26560356_Chip-Seq_TH2_Human3.67020366
7STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.37746363
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.32288180
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.14476548
10STAT4_19710469_ChIP-ChIP_TH1__Mouse3.11368842
11ELF1_17652178_ChIP-ChIP_JURKAT_Human3.07761465
12IRF8_21731497_ChIP-ChIP_J774_Mouse3.02899155
13SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.99030521
14MAF_26560356_Chip-Seq_TH1_Human2.93720256
15SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.92922290
16MYB_26560356_Chip-Seq_TH1_Human2.88006323
17FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.83533449
18UTX_26944678_Chip-Seq_JUKART_Human2.82595184
19BP1_19119308_ChIP-ChIP_Hs578T_Human2.69146600
20RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.49738492
21GATA3_27048872_Chip-Seq_THYMUS_Human2.48143837
22MAF_26560356_Chip-Seq_TH2_Human2.28536634
23MYC_22102868_ChIP-Seq_BL_Human2.14886455
24SPI1_23547873_ChIP-Seq_NB4_Human2.12731196
25E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.08952024
26SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.08679756
27IRF8_27001747_Chip-Seq_BMDM_Mouse1.96786175
28MYB_21317192_ChIP-Seq_ERMYB_Mouse1.95675351
29GATA3_26560356_Chip-Seq_TH2_Human1.93767126
30SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.89463726
31SCL_19346495_ChIP-Seq_HPC-7_Human1.89129973
32NOTCH1_21737748_ChIP-Seq_TLL_Human1.81956469
33LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.80824594
34MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.80159662
35NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.79940022
36RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.73934942
37RUNX1_22412390_ChIP-Seq_EML_Mouse1.72311008
38CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.72109450
39FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.71083776
40SMAD_19615063_ChIP-ChIP_OVARY_Human1.67794968
41SPI1_23127762_ChIP-Seq_K562_Human1.64091316
42VDR_24763502_ChIP-Seq_THP-1_Human1.62020281
43VDR_21846776_ChIP-Seq_THP-1_Human1.59527694
44LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.52608981
45BRD4_27068464_Chip-Seq_AML-cells_Mouse1.52145527
46KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.46652425
47TCF7_22412390_ChIP-Seq_EML_Mouse1.37823098
48RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.33790212
49VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.32079146
50GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.27724074
51CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.24985113
52VDR_23849224_ChIP-Seq_CD4+_Human1.23700696
53TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.22704187
54GATA2_22383799_ChIP-Seq_G1ME_Mouse1.20868902
55TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.19998111
56KDM2B_26808549_Chip-Seq_DND41_Human1.19408875
57CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.19016453
58KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.18650728
59ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.18608324
60CIITA_25753668_ChIP-Seq_RAJI_Human1.15243567
61NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.13804742
62KDM2B_26808549_Chip-Seq_SUP-B15_Human1.13424393
63SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.13034596
64BCL6_27268052_Chip-Seq_Bcells_Human1.10562659
65CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10490862
66GATA1_22383799_ChIP-Seq_G1ME_Mouse1.06834366
67FOXP3_21729870_ChIP-Seq_TREG_Human1.06783621
68CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04072944
69FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.00441665
70EGR1_19374776_ChIP-ChIP_THP-1_Human0.99730663
71NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.98773572
72SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96533945
73CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94257884
74KDM2B_26808549_Chip-Seq_JURKAT_Human0.94237635
75GATA1_19941827_ChIP-Seq_MEL_Mouse0.93345961
76PU.1_20513432_ChIP-Seq_Bcells_Mouse0.91492666
77PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.91225705
78FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91138521
79PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.88399834
80BCOR_27268052_Chip-Seq_Bcells_Human0.87208602
81VDR_24787735_ChIP-Seq_THP-1_Human0.86580700
82SPI1_20517297_ChIP-Seq_HL60_Human0.86070460
83E2F7_22180533_ChIP-Seq_HELA_Human0.84808602
84GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82058781
85TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.80138626
86IKZF1_21737484_ChIP-ChIP_HCT116_Human0.79520265
87PU_27001747_Chip-Seq_BMDM_Mouse0.78683878
88ELK3_25401928_ChIP-Seq_HUVEC_Human0.78474317
89SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78369328
90ELF1_20517297_ChIP-Seq_JURKAT_Human0.77886320
91GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77625506
92HOXB4_20404135_ChIP-ChIP_EML_Mouse0.76828032
93RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.76633995
94EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.75961701
95RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.74960198
96RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.74614204
97TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.74545477
98PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.74492674
99E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.73306075
100GATA3_26560356_Chip-Seq_TH1_Human0.72435366

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology4.82451293
2MP0005671_abnormal_response_to4.75880468
3MP0001835_abnormal_antigen_presentation3.90130169
4MP0003436_decreased_susceptibility_to3.54562292
5MP0001873_stomach_inflammation3.30208265
6MP0001800_abnormal_humoral_immune3.26952198
7MP0005000_abnormal_immune_tolerance3.24209348
8MP0009333_abnormal_splenocyte_physiolog3.20514408
9MP0000685_abnormal_immune_system3.13081336
10MP0005387_immune_system_phenotype3.03895770
11MP0001790_abnormal_immune_system3.03895770
12MP0003724_increased_susceptibility_to2.89886827
13MP0009785_altered_susceptibility_to2.76670989
14MP0005025_abnormal_response_to2.74674642
15MP0002420_abnormal_adaptive_immunity2.74559520
16MP0002723_abnormal_immune_serum2.73075855
17MP0001819_abnormal_immune_cell2.70258199
18MP0006082_CNS_inflammation2.50988415
19MP0002452_abnormal_antigen_presenting2.50170622
20MP0003866_abnormal_defecation2.50161237
21MP0000703_abnormal_thymus_morphology2.43169337
22MP0002398_abnormal_bone_marrow2.42741131
23MP0002405_respiratory_system_inflammati2.35039894
24MP0010155_abnormal_intestine_physiology2.27157259
25MP0000716_abnormal_immune_system2.23064478
26MP0002419_abnormal_innate_immunity2.22638380
27MP0002148_abnormal_hypersensitivity_rea2.22461759
28MP0004381_abnormal_hair_follicle2.01189223
29MP0001348_abnormal_lacrimal_gland2.00492631
30MP0002166_altered_tumor_susceptibility1.96205629
31MP0002722_abnormal_immune_system1.93421888
32MP0000689_abnormal_spleen_morphology1.93420885
33MP0005310_abnormal_salivary_gland1.92471009
34MP0003300_gastrointestinal_ulcer1.88663357
35MP0003303_peritoneal_inflammation1.82992187
36MP0005464_abnormal_platelet_physiology1.77584745
37MP0004947_skin_inflammation1.76539556
38MP0002429_abnormal_blood_cell1.75452416
39MP0001845_abnormal_inflammatory_respons1.71568338
40MP0000465_gastrointestinal_hemorrhage1.64850760
41MP0002277_abnormal_respiratory_mucosa1.64357214
42MP0001533_abnormal_skeleton_physiology1.56634003
43MP0002163_abnormal_gland_morphology1.48943403
44MP0005075_abnormal_melanosome_morpholog1.40849965
45MP0002933_joint_inflammation1.40610557
46MP0002396_abnormal_hematopoietic_system1.36196062
47MP0002006_tumorigenesis1.32387274
48MP0008469_abnormal_protein_level1.21625712
49MP0003806_abnormal_nucleotide_metabolis1.21508968
50MP0002132_abnormal_respiratory_system1.20212516
51MP0001851_eye_inflammation1.20148701
52MP0001986_abnormal_taste_sensitivity1.09381446
53MP0000490_abnormal_crypts_of1.06165342
54MP0005083_abnormal_biliary_tract1.02894210
55MP0001853_heart_inflammation1.02706366
56MP0001663_abnormal_digestive_system1.01559871
57MP0002138_abnormal_hepatobiliary_system0.96965584
58MP0005451_abnormal_body_composition0.94993217
59MP0000858_altered_metastatic_potential0.94752384
60MP0002693_abnormal_pancreas_physiology0.89368771
61MP0009764_decreased_sensitivity_to0.88483795
62MP0008260_abnormal_autophagy0.88370602
63MP0003448_altered_tumor_morphology0.87240870
64MP0003191_abnormal_cellular_cholesterol0.81836578
65MP0000372_irregular_coat_pigmentation0.80424992
66MP0005166_decreased_susceptibility_to0.80109416
67MP0002009_preneoplasia0.75963417
68MP0003252_abnormal_bile_duct0.75443740
69MP0002998_abnormal_bone_remodeling0.75426528
70MP0009763_increased_sensitivity_to0.74347537
71MP0001346_abnormal_lacrimal_gland0.73905091
72MP0005379_endocrine/exocrine_gland_phen0.73554458
73MP0002019_abnormal_tumor_incidence0.71866843
74MP0000604_amyloidosis0.66449337
75MP0008961_abnormal_basal_metabolism0.66377440
76MP0004808_abnormal_hematopoietic_stem0.63650364
77MP0003878_abnormal_ear_physiology0.60370410
78MP0005377_hearing/vestibular/ear_phenot0.60370410
79MP0003045_fibrosis0.60356637
80MP0008057_abnormal_DNA_replication0.57733216
81MP0004883_abnormal_blood_vessel0.57141431
82MP0005381_digestive/alimentary_phenotyp0.55922176
83MP0005390_skeleton_phenotype0.54715808
84MP0004510_myositis0.54473106
85MP0003646_muscle_fatigue0.53723215
86MP0009278_abnormal_bone_marrow0.51608544
87MP0002638_abnormal_pupillary_reflex0.51558224
88MP0001764_abnormal_homeostasis0.51412767
89MP0000249_abnormal_blood_vessel0.50839611
90MP0008004_abnormal_stomach_pH0.50554431
91MP0001919_abnormal_reproductive_system0.50345189
92MP0001765_abnormal_ion_homeostasis0.48863464
93MP0004130_abnormal_muscle_cell0.48184237
94MP0008872_abnormal_physiological_respon0.47808352
95MP0003795_abnormal_bone_structure0.47563392
96MP0009765_abnormal_xenobiotic_induced0.42891208
97MP0000609_abnormal_liver_physiology0.41038784
98MP0003828_pulmonary_edema0.40742924
99MP0000920_abnormal_myelination0.39828238
100MP0004134_abnormal_chest_morphology0.38867871

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)6.55612706
2T lymphocytopenia (HP:0005403)6.23960169
3Elevated erythrocyte sedimentation rate (HP:0003565)6.15805806
4Abnormality of T cell number (HP:0011839)6.03633956
5Autoimmune hemolytic anemia (HP:0001890)5.85392045
6Eczematoid dermatitis (HP:0000976)5.35797801
7Severe combined immunodeficiency (HP:0004430)5.26899923
8Increased IgM level (HP:0003496)5.16138593
9Abnormality of T cells (HP:0002843)5.13294484
10IgG deficiency (HP:0004315)4.76935796
11Abnormal delayed hypersensitivity skin test (HP:0002963)4.50787033
12Combined immunodeficiency (HP:0005387)4.27879572
13Recurrent fungal infections (HP:0002841)4.26855130
14Myositis (HP:0100614)4.24529404
15Abnormality of T cell physiology (HP:0011840)4.14257264
16Encephalitis (HP:0002383)3.79573318
17IgM deficiency (HP:0002850)3.73182395
18Optic neuritis (HP:0100653)3.72377768
19Retrobulbar optic neuritis (HP:0100654)3.72377768
20Abnormality of eosinophils (HP:0001879)3.69066442
21Panhypogammaglobulinemia (HP:0003139)3.68688245
22Orchitis (HP:0100796)3.59432316
23Eosinophilia (HP:0001880)3.56480250
24Abnormality of macrophages (HP:0004311)3.55850433
25Meningitis (HP:0001287)3.54440429
26Lymphopenia (HP:0001888)3.54148347
27Granulocytopenia (HP:0001913)3.54029211
28Recurrent abscess formation (HP:0002722)3.53044574
29Increased IgE level (HP:0003212)3.51917049
30Recurrent bacterial skin infections (HP:0005406)3.51358147
31B lymphocytopenia (HP:0010976)3.49339857
32Spontaneous hematomas (HP:0007420)3.45250206
33Abnormality of cells of the lymphoid lineage (HP:0012140)3.42420976
34Autoimmune thrombocytopenia (HP:0001973)3.41379558
35Abnormality of B cell number (HP:0010975)3.40229650
36Recurrent cutaneous fungal infections (HP:0011370)3.39849501
37Chronic mucocutaneous candidiasis (HP:0002728)3.39849501
38Recurrent viral infections (HP:0004429)3.38282175
39Chronic obstructive pulmonary disease (HP:0006510)3.35757034
40Obstructive lung disease (HP:0006536)3.35757034
41Recurrent bronchitis (HP:0002837)3.34668496
42Vasculitis (HP:0002633)3.34084431
43Leukocytosis (HP:0001974)3.32499247
44Mediastinal lymphadenopathy (HP:0100721)3.30127355
45Thyroiditis (HP:0100646)3.29609793
46Pustule (HP:0200039)3.24753955
47Joint swelling (HP:0001386)3.18899739
48Pulmonary infiltrates (HP:0002113)3.16126207
49Chronic diarrhea (HP:0002028)3.15909025
50Hypergammaglobulinemia (HP:0010702)3.14298325
51Prolonged bleeding time (HP:0003010)3.13793506
52Gastrointestinal infarctions (HP:0005244)3.00342372
53Keratoconjunctivitis sicca (HP:0001097)2.89909702
54Recurrent skin infections (HP:0001581)2.83442758
55Hypochromic anemia (HP:0001931)2.82941292
56Petechiae (HP:0000967)2.80443382
57Keratoconjunctivitis (HP:0001096)2.75559721
58Chest pain (HP:0100749)2.70966872
59Epistaxis (HP:0000421)2.64907411
60Hypoproteinemia (HP:0003075)2.63981494
61Recurrent gram-negative bacterial infections (HP:0005420)2.63129520
62Urticaria (HP:0001025)2.59200857
63Lymphoma (HP:0002665)2.57412090
64Acute hepatic failure (HP:0006554)2.52969879
65Hemoptysis (HP:0002105)2.52818417
66Purpura (HP:0000979)2.51380601
67Aplastic anemia (HP:0001915)2.44212576
68Hypochromic microcytic anemia (HP:0004840)2.42140374
69Hyperlipoproteinemia (HP:0010980)2.33423323
70Pulmonary embolism (HP:0002204)2.31421765
71Slow saccadic eye movements (HP:0000514)2.30005476
72Microcytic anemia (HP:0001935)2.26253323
73Hypoplasia of the thymus (HP:0000778)2.22361392
74Bronchitis (HP:0012387)2.22184606
75Gingivitis (HP:0000230)2.19496690
76Papilledema (HP:0001085)2.18711522
77Inflammation of the large intestine (HP:0002037)2.17546889
78Agammaglobulinemia (HP:0004432)2.17444871
79Arterial thrombosis (HP:0004420)2.10278645
80Gastrointestinal inflammation (HP:0004386)2.10070559
81Verrucae (HP:0200043)2.09360063
82Papilloma (HP:0012740)2.09360063
83Gingival bleeding (HP:0000225)2.08745353
84Gangrene (HP:0100758)2.07235362
85IgA deficiency (HP:0002720)2.04258680
86Recurrent sinusitis (HP:0011108)2.01031460
87Pancytopenia (HP:0001876)2.00296649
88Basal cell carcinoma (HP:0002671)2.00275216
89Anorexia (HP:0002039)2.00170810
90Chronic otitis media (HP:0000389)1.99094965
91Abnormality of the prostate (HP:0008775)1.97704857
92Nasal polyposis (HP:0100582)1.97692637
93Sepsis (HP:0100806)1.94550109
94Recurrent otitis media (HP:0000403)1.94158087
95Gastrointestinal stroma tumor (HP:0100723)1.92336236
96Aplasia/Hypoplasia of the thymus (HP:0010515)1.89462077
97Abnormality of the pleura (HP:0002103)1.87180615
98Abnormal platelet volume (HP:0011876)1.85822570
99Episodic fever (HP:0001954)1.84574698
100Keratitis (HP:0000491)1.84044032

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK5.62338563
2MAP4K15.16034600
3ITK3.03130279
4RIPK42.92663983
5ZAP702.87576942
6FES2.80095197
7TESK22.50034008
8BTK2.49715831
9KDR2.45955219
10TAOK32.45589342
11SIK32.28473483
12NLK2.15681067
13CSK2.10545769
14TNK22.07373945
15MARK31.98876190
16MAP3K111.97509781
17TYK21.94805373
18TEC1.93761655
19GRK61.91353625
20PASK1.88702307
21LCK1.84666757
22IKBKE1.82507241
23SYK1.80114754
24JAK31.67626268
25PRPF4B1.63423237
26BLK1.62112678
27HCK1.59023724
28MAP2K31.39064499
29LYN1.33722708
30EPHB11.32313708
31MAP3K121.27592556
32IRAK41.27424628
33JAK11.25611707
34TAOK11.20673938
35MAP3K31.20062075
36CAMKK11.18011906
37MAP3K141.17751986
38MST41.15799643
39SCYL21.15062936
40SIK21.14403312
41HIPK21.12080170
42PRKCQ1.10898095
43CAMKK21.08430107
44SMG11.05299871
45IKBKB1.03721342
46TAOK20.92348465
47PIM10.89027525
48CSF1R0.88738548
49ERN10.87090070
50FGFR40.85636861
51JAK20.84935751
52SIK10.77544751
53TBK10.74576103
54FGR0.71332448
55STK100.67839766
56FGFR30.66524880
57MAP3K130.64916207
58TESK10.61345563
59TLK10.59712036
60MAP3K10.59101326
61FYN0.57194698
62CLK10.53559967
63MELK0.52728883
64CDK40.51831459
65PDK10.51569371
66PIK3CG0.47826851
67GRK50.46419775
68MAP2K60.44576435
69ADRBK20.44349556
70LRRK20.44114709
71TGFBR20.42797782
72MAP3K70.42303485
73MAPKAPK20.42172944
74MAP3K100.41294804
75NUAK10.39590404
76MARK20.38949784
77KIT0.38284634
78MAPK110.36481103
79TYRO30.35223867
80MAPK120.33213723
81DAPK10.32391038
82STK110.29259270
83GRK70.27192461
84STK40.26611322
85BMPR20.25246934
86MAP3K50.24689613
87STK160.24649200
88CDK190.24529179
89TAF10.24253449
90NEK60.23863598
91TRPM70.23230856
92BCR0.21998874
93STK380.20080544
94YES10.19966670
95INSR0.19743834
96IGF1R0.19539603
97IRAK10.19533112
98PRKCH0.17967816
99PDGFRB0.17727330
100KSR20.17521441

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.84694537
2T cell receptor signaling pathway_Homo sapiens_hsa046603.84641578
3Allograft rejection_Homo sapiens_hsa053303.53044677
4Autoimmune thyroid disease_Homo sapiens_hsa053203.49291982
5Graft-versus-host disease_Homo sapiens_hsa053322.97017124
6Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.95906744
7Hematopoietic cell lineage_Homo sapiens_hsa046402.78423620
8Measles_Homo sapiens_hsa051622.69979405
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.63372443
10Antigen processing and presentation_Homo sapiens_hsa046122.36818984
11NF-kappa B signaling pathway_Homo sapiens_hsa040642.24989195
12Type I diabetes mellitus_Homo sapiens_hsa049402.16463770
13Osteoclast differentiation_Homo sapiens_hsa043802.11091049
14Intestinal immune network for IgA production_Homo sapiens_hsa046722.02988443
15Leishmaniasis_Homo sapiens_hsa051401.69385896
16RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.68927599
17Malaria_Homo sapiens_hsa051441.65876967
18Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.62270637
19Viral myocarditis_Homo sapiens_hsa054161.60943829
20Jak-STAT signaling pathway_Homo sapiens_hsa046301.58958947
21B cell receptor signaling pathway_Homo sapiens_hsa046621.58323908
22Chemokine signaling pathway_Homo sapiens_hsa040621.55073226
23Herpes simplex infection_Homo sapiens_hsa051681.52385597
24Asthma_Homo sapiens_hsa053101.47247847
25Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.43097137
26NOD-like receptor signaling pathway_Homo sapiens_hsa046211.37518084
27Acute myeloid leukemia_Homo sapiens_hsa052211.35582610
28Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.34953180
29Proteasome_Homo sapiens_hsa030501.34283569
30Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.31685731
31Toll-like receptor signaling pathway_Homo sapiens_hsa046201.24393207
32Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.17884601
33Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.17831186
34TNF signaling pathway_Homo sapiens_hsa046681.17587778
35Shigellosis_Homo sapiens_hsa051311.15319612
36Staphylococcus aureus infection_Homo sapiens_hsa051501.14598218
37Hepatitis B_Homo sapiens_hsa051611.11550446
38Platelet activation_Homo sapiens_hsa046111.08193136
39Toxoplasmosis_Homo sapiens_hsa051451.03166345
40Tuberculosis_Homo sapiens_hsa051521.01508243
41African trypanosomiasis_Homo sapiens_hsa051431.00683838
42Non-small cell lung cancer_Homo sapiens_hsa052230.98046669
43Leukocyte transendothelial migration_Homo sapiens_hsa046700.96443563
44Influenza A_Homo sapiens_hsa051640.93504735
45Apoptosis_Homo sapiens_hsa042100.91669625
46Viral carcinogenesis_Homo sapiens_hsa052030.90702956
47Pancreatic cancer_Homo sapiens_hsa052120.90138707
48Legionellosis_Homo sapiens_hsa051340.89410933
49Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.82718603
50Epstein-Barr virus infection_Homo sapiens_hsa051690.81271878
51HTLV-I infection_Homo sapiens_hsa051660.80036605
52Regulation of autophagy_Homo sapiens_hsa041400.79029345
53Ribosome_Homo sapiens_hsa030100.78500722
54Rheumatoid arthritis_Homo sapiens_hsa053230.74817690
55Colorectal cancer_Homo sapiens_hsa052100.71899340
56SNARE interactions in vesicular transport_Homo sapiens_hsa041300.68619974
57Endocytosis_Homo sapiens_hsa041440.64516180
58VEGF signaling pathway_Homo sapiens_hsa043700.62126865
59Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.61047800
60Hepatitis C_Homo sapiens_hsa051600.60638450
61Salmonella infection_Homo sapiens_hsa051320.56059364
62Chronic myeloid leukemia_Homo sapiens_hsa052200.55355646
63FoxO signaling pathway_Homo sapiens_hsa040680.51989244
64Pertussis_Homo sapiens_hsa051330.47491227
65Phosphatidylinositol signaling system_Homo sapiens_hsa040700.46279348
66Transcriptional misregulation in cancer_Homo sapiens_hsa052020.44166850
67MAPK signaling pathway_Homo sapiens_hsa040100.43275836
68Thyroid cancer_Homo sapiens_hsa052160.41833737
69Phototransduction_Homo sapiens_hsa047440.41827717
70Ras signaling pathway_Homo sapiens_hsa040140.37765155
71Endometrial cancer_Homo sapiens_hsa052130.37534737
72Olfactory transduction_Homo sapiens_hsa047400.36874524
73Systemic lupus erythematosus_Homo sapiens_hsa053220.35752091
74Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.35467874
75Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.35357912
76Phagosome_Homo sapiens_hsa041450.32386461
77Neurotrophin signaling pathway_Homo sapiens_hsa047220.31745483
78Choline metabolism in cancer_Homo sapiens_hsa052310.30578263
79Small cell lung cancer_Homo sapiens_hsa052220.27772998
80AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.27100915
81Sphingolipid signaling pathway_Homo sapiens_hsa040710.26767589
82Adipocytokine signaling pathway_Homo sapiens_hsa049200.25631351
83Prolactin signaling pathway_Homo sapiens_hsa049170.25550657
84Carbohydrate digestion and absorption_Homo sapiens_hsa049730.22429253
85Morphine addiction_Homo sapiens_hsa050320.20746629
86Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.20552371
87Regulation of actin cytoskeleton_Homo sapiens_hsa048100.20061947
88Rap1 signaling pathway_Homo sapiens_hsa040150.19915293
89Prostate cancer_Homo sapiens_hsa052150.18953536
90Renal cell carcinoma_Homo sapiens_hsa052110.18932539
91Phospholipase D signaling pathway_Homo sapiens_hsa040720.18435514
92Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.18065027
93Glycerophospholipid metabolism_Homo sapiens_hsa005640.13963956
94Long-term potentiation_Homo sapiens_hsa047200.13774245
95Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.13461250
96Insulin resistance_Homo sapiens_hsa049310.13388606
97Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.12588626
98Vascular smooth muscle contraction_Homo sapiens_hsa042700.12043204
99Pathways in cancer_Homo sapiens_hsa052000.11797692
100Linoleic acid metabolism_Homo sapiens_hsa005910.09799489

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