TRBV7-3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative T cell selection (GO:0043383)7.01039712
2regulation of isotype switching to IgG isotypes (GO:0048302)6.78733182
3negative thymic T cell selection (GO:0045060)6.64943999
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.03347005
5NIK/NF-kappaB signaling (GO:0038061)5.94744185
6antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.90413118
7antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.61110136
8activated T cell proliferation (GO:0050798)5.52858515
9tolerance induction (GO:0002507)5.28911089
10positive regulation of granulocyte differentiation (GO:0030854)5.15094543
11cellular response to interleukin-15 (GO:0071350)5.13816645
12regulation of chronic inflammatory response (GO:0002676)5.13063933
13antigen processing and presentation of endogenous antigen (GO:0019883)5.10505018
14regulation of gamma-delta T cell differentiation (GO:0045586)5.08824549
15thymic T cell selection (GO:0045061)4.97749133
16negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.93474288
17negative regulation of cell killing (GO:0031342)4.93474288
18positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.92853084
19positive regulation of gamma-delta T cell activation (GO:0046645)4.83962293
20positive T cell selection (GO:0043368)4.75065677
21response to interleukin-15 (GO:0070672)4.71068379
22T cell selection (GO:0045058)4.71046983
23regulation of T cell tolerance induction (GO:0002664)4.69908699
24positive regulation of tolerance induction (GO:0002645)4.56679863
25positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.53993569
26regulation of gamma-delta T cell activation (GO:0046643)4.51111346
27CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)4.48632363
28regulation of regulatory T cell differentiation (GO:0045589)4.39362392
29T cell mediated immunity (GO:0002456)4.19244165
30positive regulation of isotype switching (GO:0045830)4.17904664
31interferon-gamma production (GO:0032609)4.17354748
32positive regulation of T cell differentiation in thymus (GO:0033089)4.16945940
33positive thymic T cell selection (GO:0045059)4.07129161
34leukocyte aggregation (GO:0070486)4.02108361
35regulation of interleukin-2 biosynthetic process (GO:0045076)3.96369882
36positive regulation of natural killer cell mediated immunity (GO:0002717)3.96157584
37regulation of tolerance induction (GO:0002643)3.94486236
38alpha-beta T cell differentiation (GO:0046632)3.93525098
39positive regulation of DNA recombination (GO:0045911)3.92422490
40regulation of natural killer cell mediated immunity (GO:0002715)3.90023644
41regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.90023644
42negative regulation of T-helper cell differentiation (GO:0045623)3.88644851
43negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.88644851
44T cell migration (GO:0072678)3.87391522
45T-helper cell differentiation (GO:0042093)3.87023214
46CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.87023214
47negative regulation of T cell mediated immunity (GO:0002710)3.84865498
48regulation of T cell mediated cytotoxicity (GO:0001914)3.84354871
49regulation of isotype switching (GO:0045191)3.83433474
50positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.81173349
51negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.76480972
52regulation of B cell receptor signaling pathway (GO:0050855)3.74734406
53alpha-beta T cell differentiation involved in immune response (GO:0002293)3.73256981
54alpha-beta T cell activation involved in immune response (GO:0002287)3.73256981
55T cell differentiation involved in immune response (GO:0002292)3.73256981
56regulation of leukocyte mediated cytotoxicity (GO:0001910)3.73154123
57regulation of immunoglobulin secretion (GO:0051023)3.69949062
58positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.69217444
59positive regulation of T cell mediated cytotoxicity (GO:0001916)3.65686540
60positive regulation of chemokine biosynthetic process (GO:0045080)3.65465592
61mast cell activation (GO:0045576)3.64775978
62regulation of alpha-beta T cell proliferation (GO:0046640)3.60967651
63regulation of immunoglobulin production (GO:0002637)3.60272920
64positive regulation of cell killing (GO:0031343)3.56791347
65CD4-positive, alpha-beta T cell differentiation (GO:0043367)3.55612857
66negative regulation of necroptotic process (GO:0060546)3.54066878
67defense response to protozoan (GO:0042832)3.50966568
68negative regulation of lymphocyte mediated immunity (GO:0002707)3.50265380
69alpha-beta T cell activation (GO:0046631)3.49921732
70regulation of cell killing (GO:0031341)3.49855188
71positive regulation of immunoglobulin production (GO:0002639)3.48005607
72regulation of granulocyte differentiation (GO:0030852)3.45168417
73regulation of thymocyte apoptotic process (GO:0070243)3.43826690
74regulation of chemokine biosynthetic process (GO:0045073)3.41927143
75positive regulation of alpha-beta T cell proliferation (GO:0046641)3.40688962
76negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.39432366
77mast cell activation involved in immune response (GO:0002279)3.39049511
78mast cell degranulation (GO:0043303)3.39049511
79T cell homeostasis (GO:0043029)3.38981435
80regulation of necroptotic process (GO:0060544)3.38284962
81negative regulation of interleukin-12 production (GO:0032695)3.34224693
82antigen processing and presentation via MHC class Ib (GO:0002475)3.33295734
83T cell receptor signaling pathway (GO:0050852)3.33252293
84positive regulation of lymphocyte mediated immunity (GO:0002708)3.31321999
85response to xenobiotic stimulus (GO:0009410)3.30178285
86positive regulation of immunoglobulin mediated immune response (GO:0002891)3.30074091
87positive regulation of B cell mediated immunity (GO:0002714)3.30074091
88lymphocyte costimulation (GO:0031294)3.26302474
89CD4-positive, alpha-beta T cell activation (GO:0035710)3.24123838
90positive regulation of interleukin-4 production (GO:0032753)3.20149845
91cytokine biosynthetic process (GO:0042089)3.16523054
92T cell lineage commitment (GO:0002360)3.15881005
93regulation of RIG-I signaling pathway (GO:0039535)3.11828694
94negative regulation of adaptive immune response (GO:0002820)3.11526342
95positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.10739940
96regulation of interleukin-12 biosynthetic process (GO:0045075)3.10712943
97regulation of defense response to virus by virus (GO:0050690)3.09359673
98regulation of interleukin-13 production (GO:0032656)3.07473834
99T cell costimulation (GO:0031295)3.06210505
100response to protozoan (GO:0001562)3.06144139

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_20620947_ChIP-Seq_CD4_POS_T_Human6.31940431
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse6.15833637
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.66540688
4IRF8_22096565_ChIP-ChIP_GC-B_Human4.58480107
5RUNX_20019798_ChIP-Seq_JUKART_Human3.82313120
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.75518483
7MYB_26560356_Chip-Seq_TH2_Human3.55506964
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.39091707
9BP1_19119308_ChIP-ChIP_Hs578T_Human3.23923645
10STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.20428722
11STAT4_19710469_ChIP-ChIP_TH1__Mouse3.20064972
12SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.84046641
13IRF8_21731497_ChIP-ChIP_J774_Mouse2.71829631
14MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.68819512
15MYB_26560356_Chip-Seq_TH1_Human2.61151390
16MAF_26560356_Chip-Seq_TH1_Human2.53573407
17FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.49639728
18ELF1_17652178_ChIP-ChIP_JURKAT_Human2.32004292
19GATA3_27048872_Chip-Seq_THYMUS_Human2.31968444
20UTX_26944678_Chip-Seq_JUKART_Human2.25178753
21RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.25035960
22FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.19822396
23CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.15514364
24GATA3_26560356_Chip-Seq_TH2_Human2.11510655
25NOTCH1_21737748_ChIP-Seq_TLL_Human2.10724411
26LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.07453463
27MAF_26560356_Chip-Seq_TH2_Human1.99245951
28E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.70016652
29IKZF1_21737484_ChIP-ChIP_HCT116_Human1.65770284
30LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.61444275
31SPI1_23547873_ChIP-Seq_NB4_Human1.61036306
32BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.60679359
33RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.58088357
34SMAD_19615063_ChIP-ChIP_OVARY_Human1.56618972
35IRF8_27001747_Chip-Seq_BMDM_Mouse1.56383298
36SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.50476008
37SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.49685882
38SPI1_23127762_ChIP-Seq_K562_Human1.44535602
39SCL_19346495_ChIP-Seq_HPC-7_Human1.41847335
40MYB_21317192_ChIP-Seq_ERMYB_Mouse1.39587798
41MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.33914555
42MYC_22102868_ChIP-Seq_BL_Human1.31986429
43CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.31832618
44NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.29174383
45FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.27520997
46GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.26012046
47SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.25331574
48EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.24810032
49RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.22220730
50RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.18450410
51BCL6_27268052_Chip-Seq_Bcells_Human1.16779935
52GATA2_22383799_ChIP-Seq_G1ME_Mouse1.13112978
53VDR_24763502_ChIP-Seq_THP-1_Human1.10495059
54SPI1_20517297_ChIP-Seq_HL60_Human1.08566440
55KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.07565160
56VDR_23849224_ChIP-Seq_CD4+_Human1.02885052
57ELF1_20517297_ChIP-Seq_JURKAT_Human1.02104996
58CEBPB_22108803_ChIP-Seq_LS180_Human1.01833802
59NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.01773103
60SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98869130
61TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.97941002
62TCF7_22412390_ChIP-Seq_EML_Mouse0.97626966
63VDR_24787735_ChIP-Seq_THP-1_Human0.96060888
64BRD4_27068464_Chip-Seq_AML-cells_Mouse0.96035210
65CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95639354
66TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.93582237
67BCOR_27268052_Chip-Seq_Bcells_Human0.93189047
68RUNX1_22412390_ChIP-Seq_EML_Mouse0.91299486
69GATA3_26560356_Chip-Seq_TH1_Human0.89860250
70SA1_27219007_Chip-Seq_Bcells_Human0.89712708
71PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.89595979
72CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.89476060
73GATA1_22383799_ChIP-Seq_G1ME_Mouse0.88193955
74PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.87299160
75NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.86780177
76FOXP3_21729870_ChIP-Seq_TREG_Human0.85973397
77TAF2_19829295_ChIP-Seq_ESCs_Human0.85718162
78FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83776703
79TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.83692522
80GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83536520
81NANOG_20526341_ChIP-Seq_ESCs_Human0.82627060
82RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.81776576
83CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.81343842
84GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.80495052
85PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.79798150
86GATA1_19941827_ChIP-Seq_MEL_Mouse0.79595960
87SALL4_22934838_ChIP-ChIP_CD34+_Human0.78415424
88CTCF_21964334_ChIP-Seq_BJAB-B_Human0.77776438
89RAC3_21632823_ChIP-Seq_H3396_Human0.77613347
90VDR_21846776_ChIP-Seq_THP-1_Human0.76992198
91TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.74813710
92FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.74298088
93PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.74015063
94PRDM14_20953172_ChIP-Seq_ESCs_Human0.73898099
95P300_27268052_Chip-Seq_Bcells_Human0.73616229
96SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.73358676
97VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.73305191
98PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.72827005
99GATA6_21074721_ChIP-Seq_CACO-2_Human0.71711032
100GATA3_21878914_ChIP-Seq_MCF-7_Human0.71648193

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.78024226
2MP0001348_abnormal_lacrimal_gland4.49327158
3MP0003763_abnormal_thymus_physiology4.22186083
4MP0001835_abnormal_antigen_presentation3.87116616
5MP0001873_stomach_inflammation3.78899393
6MP0006082_CNS_inflammation3.27826639
7MP0003436_decreased_susceptibility_to3.24101320
8MP0000685_abnormal_immune_system3.22242939
9MP0001800_abnormal_humoral_immune3.00165201
10MP0005000_abnormal_immune_tolerance2.98646516
11MP0009333_abnormal_splenocyte_physiolog2.87803400
12MP0001790_abnormal_immune_system2.83998135
13MP0005387_immune_system_phenotype2.83998135
14MP0002723_abnormal_immune_serum2.57756015
15MP0005310_abnormal_salivary_gland2.51966155
16MP0005025_abnormal_response_to2.48244176
17MP0009785_altered_susceptibility_to2.47776732
18MP0002420_abnormal_adaptive_immunity2.39788597
19MP0001819_abnormal_immune_cell2.35813935
20MP0002452_abnormal_antigen_presenting2.25551389
21MP0002163_abnormal_gland_morphology2.19250868
22MP0003724_increased_susceptibility_to2.09861198
23MP0002398_abnormal_bone_marrow2.09610289
24MP0002405_respiratory_system_inflammati2.04893911
25MP0005410_abnormal_fertilization2.03794814
26MP0010155_abnormal_intestine_physiology2.02883444
27MP0002148_abnormal_hypersensitivity_rea1.97926539
28MP0003866_abnormal_defecation1.95575762
29MP0000703_abnormal_thymus_morphology1.93168555
30MP0000716_abnormal_immune_system1.92762222
31MP0005451_abnormal_body_composition1.92466907
32MP0002419_abnormal_innate_immunity1.90441223
33MP0001986_abnormal_taste_sensitivity1.81862192
34MP0002166_altered_tumor_susceptibility1.71103155
35MP0004947_skin_inflammation1.65816963
36MP0005379_endocrine/exocrine_gland_phen1.62207566
37MP0000689_abnormal_spleen_morphology1.60877900
38MP0002722_abnormal_immune_system1.59365665
39MP0005464_abnormal_platelet_physiology1.59341291
40MP0001845_abnormal_inflammatory_respons1.58366396
41MP0002429_abnormal_blood_cell1.51252270
42MP0003878_abnormal_ear_physiology1.42372144
43MP0005377_hearing/vestibular/ear_phenot1.42372144
44MP0002138_abnormal_hepatobiliary_system1.39997256
45MP0002933_joint_inflammation1.37379874
46MP0002277_abnormal_respiratory_mucosa1.36105208
47MP0003646_muscle_fatigue1.33572247
48MP0001533_abnormal_skeleton_physiology1.33144313
49MP0003303_peritoneal_inflammation1.28241419
50MP0003806_abnormal_nucleotide_metabolis1.27250685
51MP0003300_gastrointestinal_ulcer1.25227989
52MP0002132_abnormal_respiratory_system1.25214243
53MP0004381_abnormal_hair_follicle1.18688641
54MP0008469_abnormal_protein_level1.17507144
55MP0008872_abnormal_physiological_respon1.16432146
56MP0002006_tumorigenesis1.15787004
57MP0005083_abnormal_biliary_tract1.03182810
58MP0009764_decreased_sensitivity_to0.97517821
59MP0008875_abnormal_xenobiotic_pharmacok0.97147373
60MP0001663_abnormal_digestive_system0.95947895
61MP0001851_eye_inflammation0.95659863
62MP0000465_gastrointestinal_hemorrhage0.95247147
63MP0002876_abnormal_thyroid_physiology0.94236102
64MP0001346_abnormal_lacrimal_gland0.93895763
65MP0002693_abnormal_pancreas_physiology0.90922782
66MP0000604_amyloidosis0.84325773
67MP0005166_decreased_susceptibility_to0.80716323
68MP0005075_abnormal_melanosome_morpholog0.78452544
69MP0000372_irregular_coat_pigmentation0.78219286
70MP0005423_abnormal_somatic_nervous0.76046705
71MP0001765_abnormal_ion_homeostasis0.74484544
72MP0003252_abnormal_bile_duct0.73837256
73MP0004808_abnormal_hematopoietic_stem0.72660016
74MP0000490_abnormal_crypts_of0.67319897
75MP0008961_abnormal_basal_metabolism0.66549682
76MP0004742_abnormal_vestibular_system0.66381169
77MP0002396_abnormal_hematopoietic_system0.66119141
78MP0001853_heart_inflammation0.61501325
79MP0001968_abnormal_touch/_nociception0.60503656
80MP0009763_increased_sensitivity_to0.59587669
81MP0000858_altered_metastatic_potential0.58063143
82MP0004134_abnormal_chest_morphology0.57358106
83MP0004510_myositis0.56271059
84MP0002998_abnormal_bone_remodeling0.55773805
85MP0002019_abnormal_tumor_incidence0.54910043
86MP0002009_preneoplasia0.54532725
87MP0000249_abnormal_blood_vessel0.53616502
88MP0003448_altered_tumor_morphology0.52374614
89MP0003045_fibrosis0.51555038
90MP0000750_abnormal_muscle_regeneration0.51218791
91MP0005381_digestive/alimentary_phenotyp0.51177476
92MP0005390_skeleton_phenotype0.50359921
93MP0003698_abnormal_male_reproductive0.46849853
94MP0003879_abnormal_hair_cell0.46749115
95MP0003943_abnormal_hepatobiliary_system0.46268470
96MP0009765_abnormal_xenobiotic_induced0.45273489
97MP0001501_abnormal_sleep_pattern0.45091957
98MP0001929_abnormal_gametogenesis0.45066322
99MP0000609_abnormal_liver_physiology0.43588985
100MP0003795_abnormal_bone_structure0.43391812

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)6.86696502
2Abnormality of T cell number (HP:0011839)5.85336265
3T lymphocytopenia (HP:0005403)5.69914480
4Autoimmune hemolytic anemia (HP:0001890)5.51160171
5Increased IgM level (HP:0003496)5.46136676
6Elevated erythrocyte sedimentation rate (HP:0003565)5.25003582
7Severe combined immunodeficiency (HP:0004430)5.22973085
8Abnormality of T cells (HP:0002843)5.06189958
9IgG deficiency (HP:0004315)5.03479189
10Abnormal delayed hypersensitivity skin test (HP:0002963)4.62990465
11Abnormality of T cell physiology (HP:0011840)4.37657099
12Combined immunodeficiency (HP:0005387)4.15250595
13Recurrent fungal infections (HP:0002841)4.04417007
14Eczematoid dermatitis (HP:0000976)4.00208188
15Autoimmune thrombocytopenia (HP:0001973)3.97128218
16Abnormality of eosinophils (HP:0001879)3.85203379
17Nasal polyposis (HP:0100582)3.59100307
18Recurrent cutaneous fungal infections (HP:0011370)3.58185437
19Chronic mucocutaneous candidiasis (HP:0002728)3.58185437
20Thyroiditis (HP:0100646)3.52054970
21Recurrent bronchitis (HP:0002837)3.51039533
22Myositis (HP:0100614)3.47328134
23Eosinophilia (HP:0001880)3.46746091
24Panhypogammaglobulinemia (HP:0003139)3.37259638
25Pulmonary infiltrates (HP:0002113)3.31728883
26Hypoproteinemia (HP:0003075)3.31274209
27Hypoplasia of the thymus (HP:0000778)3.27433647
28Leukocytosis (HP:0001974)3.26141030
29Granulocytopenia (HP:0001913)3.26024956
30Optic neuritis (HP:0100653)3.24157688
31Retrobulbar optic neuritis (HP:0100654)3.24157688
32Chronic diarrhea (HP:0002028)3.23140089
33Increased IgE level (HP:0003212)3.20114045
34Hypergammaglobulinemia (HP:0010702)3.15038662
35Encephalitis (HP:0002383)3.11244886
36Aplastic anemia (HP:0001915)3.11230388
37Joint swelling (HP:0001386)3.08220725
38Hyperlipoproteinemia (HP:0010980)3.06669426
39Mediastinal lymphadenopathy (HP:0100721)3.03144516
40Orchitis (HP:0100796)2.99385933
41B lymphocytopenia (HP:0010976)2.97360242
42Abnormality of the nasal mucosa (HP:0000433)2.94971595
43Abnormality of macrophages (HP:0004311)2.91857922
44Vasculitis (HP:0002633)2.84840643
45Prolonged bleeding time (HP:0003010)2.83667550
46Fatigue (HP:0012378)2.78077758
47Abnormality of B cell number (HP:0010975)2.77460001
48Recurrent viral infections (HP:0004429)2.76985713
49Chronic hepatic failure (HP:0100626)2.76732667
50Meningitis (HP:0001287)2.76322444
51Pustule (HP:0200039)2.75391133
52Abnormality of cells of the lymphoid lineage (HP:0012140)2.73675522
53Recurrent skin infections (HP:0001581)2.63905069
54Bronchitis (HP:0012387)2.60926519
55Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.60788669
56Lymphopenia (HP:0001888)2.60285744
57Chronic otitis media (HP:0000389)2.59615669
58Recurrent bacterial skin infections (HP:0005406)2.58336913
59Keratoconjunctivitis sicca (HP:0001097)2.49822726
60Gastrointestinal infarctions (HP:0005244)2.47993722
61Keratoconjunctivitis (HP:0001096)2.47720821
62IgM deficiency (HP:0002850)2.47414859
63Hypochromic anemia (HP:0001931)2.44426469
64Gingivitis (HP:0000230)2.43754917
65IgA deficiency (HP:0002720)2.43034854
66Recurrent abscess formation (HP:0002722)2.42842487
67Epistaxis (HP:0000421)2.42489359
68Hemoptysis (HP:0002105)2.39532941
69Spontaneous hematomas (HP:0007420)2.37317305
70Obstructive lung disease (HP:0006536)2.36823809
71Chronic obstructive pulmonary disease (HP:0006510)2.36823809
72Lymphoma (HP:0002665)2.36172821
73Petechiae (HP:0000967)2.34710633
74Hypoalbuminemia (HP:0003073)2.30268210
75Abnormal albumin level (HP:0012116)2.30268210
76Dynein arm defect of respiratory motile cilia (HP:0012255)2.22033497
77Absent/shortened dynein arms (HP:0200106)2.22033497
78Oral leukoplakia (HP:0002745)2.19780174
79Chest pain (HP:0100749)2.16486531
80Polyneuropathy (HP:0001271)2.16383427
81Purpura (HP:0000979)2.07108794
82Chronic sinusitis (HP:0011109)1.99930493
83Bronchiectasis (HP:0002110)1.98575425
84Agammaglobulinemia (HP:0004432)1.97626573
85Pancytopenia (HP:0001876)1.94509026
86Keratitis (HP:0000491)1.90674686
87Urticaria (HP:0001025)1.88227158
88Amyotrophic lateral sclerosis (HP:0007354)1.87795440
89Slow saccadic eye movements (HP:0000514)1.87565641
90Absent rod-and cone-mediated responses on ERG (HP:0007688)1.86168670
913-Methylglutaconic aciduria (HP:0003535)1.85805043
92Abnormality of the prostate (HP:0008775)1.84371465
93Neutropenia (HP:0001875)1.83519144
94Abnormal respiratory motile cilium physiology (HP:0012261)1.82784215
95Pulmonary fibrosis (HP:0002206)1.81951854
96Recurrent otitis media (HP:0000403)1.81395682
97Gingival bleeding (HP:0000225)1.79908362
98Hepatitis (HP:0012115)1.79861511
99Recurrent sinusitis (HP:0011108)1.78674073
100Gangrene (HP:0100758)1.78027395

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK4.78638412
2MAP4K14.73261097
3ITK3.20038332
4TAOK32.91255677
5RIPK42.89764068
6FES2.75216095
7ZAP702.60722584
8BTK2.37044762
9PLK42.33600066
10MST42.15396732
11BRD42.03698649
12TEC2.00268094
13MAP3K111.97542648
14PIK3CG1.90726404
15KDR1.87039491
16CSK1.76311216
17MAP2K31.73186365
18HIPK21.72436245
19TAOK21.69744440
20EPHB11.69266269
21SYK1.64413935
22SCYL21.64142343
23MAP3K31.62497649
24LCK1.61500339
25TGFBR21.58985966
26TESK21.56862627
27JAK31.47706566
28BCR1.46316734
29MARK31.45993182
30IKBKB1.41828601
31GRK61.38501075
32IKBKE1.37794256
33NLK1.37647523
34HCK1.37157689
35AKT31.35380134
36TYK21.35184169
37MAP3K121.32099551
38BLK1.31102670
39TNK21.28163958
40INSRR1.26852141
41TAOK11.21262171
42JAK11.19402296
43LYN1.18550634
44ADRBK21.15580172
45STK161.12507826
46CSF1R1.12439015
47PASK1.09268466
48MAP3K141.07929233
49TYRO31.05983241
50NUAK11.01244401
51PIM10.99616584
52CAMKK20.92458200
53NEK60.91249268
54SIK30.89989523
55PRKCQ0.86974921
56PDK10.83483274
57MYLK0.82270515
58TLK10.77901462
59PBK0.72736631
60STK240.72103618
61PRPF4B0.71956914
62DYRK20.70932219
63FGFR40.69223700
64STK100.66449602
65CAMKK10.66435773
66TRPM70.63257779
67TBK10.62533796
68IRAK40.61803361
69MAP2K60.60839482
70JAK20.60323106
71DAPK10.57046797
72GRK70.55737656
73STK380.54949027
74STK38L0.53034417
75CDK40.52394326
76PTK2B0.52391570
77STK40.51948093
78MAP3K70.43570617
79FGFR30.41951301
80CLK10.41071192
81EPHA30.40493453
82TESK10.39000711
83NME10.38256484
84MAPKAPK20.36469301
85MAP3K10.35828241
86KIT0.34964484
87MAP3K130.33207335
88GRK50.32248647
89WNK10.31330435
90CHUK0.30506184
91TIE10.29909103
92MAPK110.28963125
93SMG10.28360863
94BMPR20.24990565
95FYN0.24162166
96FGR0.23808919
97PDPK10.23571637
98IRAK10.20684683
99BRAF0.20351140
100ADRBK10.19318563

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.80362899
2Allograft rejection_Homo sapiens_hsa053304.27114577
3Autoimmune thyroid disease_Homo sapiens_hsa053204.08226758
4T cell receptor signaling pathway_Homo sapiens_hsa046603.63722087
5Inflammatory bowel disease (IBD)_Homo sapiens_hsa053213.17038641
6Graft-versus-host disease_Homo sapiens_hsa053322.86866579
7Antigen processing and presentation_Homo sapiens_hsa046122.73942835
8Hematopoietic cell lineage_Homo sapiens_hsa046402.73064646
9Intestinal immune network for IgA production_Homo sapiens_hsa046722.65185126
10Measles_Homo sapiens_hsa051622.61772806
11Asthma_Homo sapiens_hsa053102.54518861
12NF-kappa B signaling pathway_Homo sapiens_hsa040642.52201277
13Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.50239748
14Type I diabetes mellitus_Homo sapiens_hsa049402.15689288
15Jak-STAT signaling pathway_Homo sapiens_hsa046301.72876694
16Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.70299759
17NOD-like receptor signaling pathway_Homo sapiens_hsa046211.60508247
18Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.57670188
19Osteoclast differentiation_Homo sapiens_hsa043801.53547061
20RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.53497762
21Viral myocarditis_Homo sapiens_hsa054161.43470184
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.38248199
23Leishmaniasis_Homo sapiens_hsa051401.36538645
24Chemokine signaling pathway_Homo sapiens_hsa040621.35246448
25Proteasome_Homo sapiens_hsa030501.35073802
26Malaria_Homo sapiens_hsa051441.28126462
27Legionellosis_Homo sapiens_hsa051341.27731498
28Herpes simplex infection_Homo sapiens_hsa051681.27392925
29TNF signaling pathway_Homo sapiens_hsa046681.24299315
30Toll-like receptor signaling pathway_Homo sapiens_hsa046201.12616473
31African trypanosomiasis_Homo sapiens_hsa051431.12104607
32Toxoplasmosis_Homo sapiens_hsa051451.09983391
33B cell receptor signaling pathway_Homo sapiens_hsa046621.08991572
34Acute myeloid leukemia_Homo sapiens_hsa052211.01018864
35Influenza A_Homo sapiens_hsa051641.00378486
36Platelet activation_Homo sapiens_hsa046110.98749736
37Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.96923368
38Hepatitis B_Homo sapiens_hsa051610.92215384
39Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.91217813
40Apoptosis_Homo sapiens_hsa042100.89787571
41Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.84141787
42Olfactory transduction_Homo sapiens_hsa047400.78201897
43Phototransduction_Homo sapiens_hsa047440.77160751
44Shigellosis_Homo sapiens_hsa051310.74734756
45Ribosome_Homo sapiens_hsa030100.71074208
46Non-small cell lung cancer_Homo sapiens_hsa052230.70431881
47Viral carcinogenesis_Homo sapiens_hsa052030.70229644
48Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.67374937
49Tuberculosis_Homo sapiens_hsa051520.67254313
50Rheumatoid arthritis_Homo sapiens_hsa053230.66143720
51Regulation of autophagy_Homo sapiens_hsa041400.65870860
52VEGF signaling pathway_Homo sapiens_hsa043700.64271507
53Staphylococcus aureus infection_Homo sapiens_hsa051500.64046266
54Epstein-Barr virus infection_Homo sapiens_hsa051690.61136005
55Pancreatic cancer_Homo sapiens_hsa052120.60966809
56Transcriptional misregulation in cancer_Homo sapiens_hsa052020.58522276
57Leukocyte transendothelial migration_Homo sapiens_hsa046700.56773884
58Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.56061907
59Nitrogen metabolism_Homo sapiens_hsa009100.55598699
60Fatty acid biosynthesis_Homo sapiens_hsa000610.50186803
61Linoleic acid metabolism_Homo sapiens_hsa005910.50075606
62MAPK signaling pathway_Homo sapiens_hsa040100.48512135
63Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.47364554
64Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.46800011
65HTLV-I infection_Homo sapiens_hsa051660.46526390
66Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.45391741
67Endocytosis_Homo sapiens_hsa041440.44096007
68Hepatitis C_Homo sapiens_hsa051600.43792646
69Adipocytokine signaling pathway_Homo sapiens_hsa049200.42927704
70FoxO signaling pathway_Homo sapiens_hsa040680.40572938
71SNARE interactions in vesicular transport_Homo sapiens_hsa041300.38347714
72alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.38154185
73Carbohydrate digestion and absorption_Homo sapiens_hsa049730.31796460
74Arachidonic acid metabolism_Homo sapiens_hsa005900.31138449
75Glutathione metabolism_Homo sapiens_hsa004800.30408714
76Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.30008943
77Phosphatidylinositol signaling system_Homo sapiens_hsa040700.29546565
78Morphine addiction_Homo sapiens_hsa050320.25598406
79Systemic lupus erythematosus_Homo sapiens_hsa053220.23800507
80Salmonella infection_Homo sapiens_hsa051320.23149375
81Pertussis_Homo sapiens_hsa051330.20950001
82Caffeine metabolism_Homo sapiens_hsa002320.20884883
83Colorectal cancer_Homo sapiens_hsa052100.20559893
84Vascular smooth muscle contraction_Homo sapiens_hsa042700.18111257
85Small cell lung cancer_Homo sapiens_hsa052220.17668245
86Ras signaling pathway_Homo sapiens_hsa040140.16971737
87Glycerophospholipid metabolism_Homo sapiens_hsa005640.15459165
88ABC transporters_Homo sapiens_hsa020100.13790196
89RNA transport_Homo sapiens_hsa030130.13360504
90Glycerolipid metabolism_Homo sapiens_hsa005610.13176903
91Thyroid cancer_Homo sapiens_hsa052160.11662421
92Sphingolipid signaling pathway_Homo sapiens_hsa040710.11276310
93AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.10559122
94Dorso-ventral axis formation_Homo sapiens_hsa043200.07760733
95Chronic myeloid leukemia_Homo sapiens_hsa052200.07316159
96Insulin resistance_Homo sapiens_hsa049310.06337406
97Type II diabetes mellitus_Homo sapiens_hsa049300.05358302
98Steroid hormone biosynthesis_Homo sapiens_hsa001400.05267295
99Renin secretion_Homo sapiens_hsa049240.04940798
100Prolactin signaling pathway_Homo sapiens_hsa049170.04545711

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