TRBV7-4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1thrombin receptor signaling pathway (GO:0070493)8.16432697
2protein neddylation (GO:0045116)6.76710533
3neutrophil activation involved in immune response (GO:0002283)6.66656698
4negative regulation of thymocyte apoptotic process (GO:0070244)6.25738127
5blood coagulation, intrinsic pathway (GO:0007597)5.83128942
6G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)5.77936376
7triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.75798677
8regulation of platelet aggregation (GO:0090330)5.69197606
9regulation of platelet activation (GO:0010543)5.52031218
10purinergic nucleotide receptor signaling pathway (GO:0035590)5.19514057
11adenosine receptor signaling pathway (GO:0001973)5.02185695
12platelet aggregation (GO:0070527)4.90884314
13positive regulation of macrophage differentiation (GO:0045651)4.90740490
14leukocyte migration involved in inflammatory response (GO:0002523)4.90405082
15negative regulation of macrophage derived foam cell differentiation (GO:0010745)4.82276180
16low-density lipoprotein particle remodeling (GO:0034374)4.80538256
17angiogenesis involved in wound healing (GO:0060055)4.75803631
18negative regulation of norepinephrine secretion (GO:0010700)4.70612829
19positive regulation of endothelial cell differentiation (GO:0045603)4.69085856
20negative regulation of heart rate (GO:0010459)4.68362374
21fusion of sperm to egg plasma membrane (GO:0007342)4.53882566
22negative regulation of platelet activation (GO:0010544)4.52514757
23negative regulation of homotypic cell-cell adhesion (GO:0034111)4.49145785
24lipoxygenase pathway (GO:0019372)4.46172927
25positive regulation of mast cell activation (GO:0033005)4.31193988
26purinergic receptor signaling pathway (GO:0035587)4.30813788
27regulation of transforming growth factor beta2 production (GO:0032909)4.25624096
28G-protein coupled purinergic receptor signaling pathway (GO:0035588)4.22977604
29regulation of integrin-mediated signaling pathway (GO:2001044)4.19369149
30positive regulation of mitochondrial calcium ion concentration (GO:0051561)4.16711962
31neutrophil activation (GO:0042119)4.09059868
32negative regulation of T cell apoptotic process (GO:0070233)4.05960892
33mitochondrial calcium ion transport (GO:0006851)3.98404839
34positive regulation of cAMP-mediated signaling (GO:0043950)3.95653834
35regulation of integrin activation (GO:0033623)3.78502213
36activated T cell proliferation (GO:0050798)3.76660908
37regulation of RIG-I signaling pathway (GO:0039535)3.75644975
38platelet activation (GO:0030168)3.75540591
39negative regulation of appetite (GO:0032099)3.73821955
40negative regulation of response to food (GO:0032096)3.73821955
41positive regulation of granulocyte differentiation (GO:0030854)3.66708107
42platelet degranulation (GO:0002576)3.64779351
43positive regulation of protein homodimerization activity (GO:0090073)3.60206595
44negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.60078412
45regulation of macrophage derived foam cell differentiation (GO:0010743)3.55893063
46regulation of lipoprotein metabolic process (GO:0050746)3.54240886
47megakaryocyte development (GO:0035855)3.54190146
48granulocyte activation (GO:0036230)3.51877632
49platelet formation (GO:0030220)3.50697121
50positive regulation of Rho protein signal transduction (GO:0035025)3.46357342
51positive regulation of systemic arterial blood pressure (GO:0003084)3.43350286
52homotypic cell-cell adhesion (GO:0034109)3.43243902
53regulation of thymocyte apoptotic process (GO:0070243)3.42807226
54beta-amyloid metabolic process (GO:0050435)3.40401751
55high-density lipoprotein particle remodeling (GO:0034375)3.39877644
56polyamine biosynthetic process (GO:0006596)3.37520788
57regulation of homotypic cell-cell adhesion (GO:0034110)3.37101625
58regulation of Golgi to plasma membrane protein transport (GO:0042996)3.36867792
59phospholipid homeostasis (GO:0055091)3.33818207
60regulation of cholesterol efflux (GO:0010874)3.32978510
61plasma membrane fusion (GO:0045026)3.28320790
62negative regulation of neural precursor cell proliferation (GO:2000178)3.25913473
63negative regulation of protein localization to cell surface (GO:2000009)3.24322597
64regulation of norepinephrine secretion (GO:0014061)3.22758717
65fibril organization (GO:0097435)3.21310404
66reverse cholesterol transport (GO:0043691)3.18122871
67positive regulation of T cell cytokine production (GO:0002726)3.16639703
68negative regulation of heart contraction (GO:0045822)3.16467161
69regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.15687352
70regulation of endothelial cell differentiation (GO:0045601)3.14974239
71positive regulation of natural killer cell mediated immunity (GO:0002717)3.14485694
72negative regulation of stress fiber assembly (GO:0051497)3.11269566
73autophagic vacuole fusion (GO:0000046)3.11231155
74antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.10929467
75long-chain fatty acid biosynthetic process (GO:0042759)3.10748124
76regulation of MHC class II biosynthetic process (GO:0045346)3.10645135
77platelet dense granule organization (GO:0060155)3.06803346
78monoamine transport (GO:0015844)3.03878327
79cellular response to arsenic-containing substance (GO:0071243)3.02777781
80positive regulation of hemostasis (GO:1900048)3.02735114
81positive regulation of blood coagulation (GO:0030194)3.02735114
82phagocytosis, engulfment (GO:0006911)3.01090807
83leukocyte degranulation (GO:0043299)2.93640503
84regulation of mast cell activation (GO:0033003)2.92383711
85Arp2/3 complex-mediated actin nucleation (GO:0034314)2.89450978
86termination of G-protein coupled receptor signaling pathway (GO:0038032)2.88204934
87negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.87322301
88negative regulation of T-helper cell differentiation (GO:0045623)2.87322301
89positive regulation of transforming growth factor beta production (GO:0071636)2.85836048
90protein localization to cell surface (GO:0034394)2.83857809
91negative regulation of catecholamine secretion (GO:0033604)2.83739282
92negative regulation of phosphoprotein phosphatase activity (GO:0032515)2.82050469
93regulation of memory T cell differentiation (GO:0043380)2.81928620
94termination of signal transduction (GO:0023021)2.81399899
95positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.80986860
96extracellular fibril organization (GO:0043206)2.79262772
97positive regulation of mast cell degranulation (GO:0043306)2.78208823
98positive regulation of mast cell activation involved in immune response (GO:0033008)2.78208823
99positive regulation of toll-like receptor signaling pathway (GO:0034123)2.76415818
100negative regulation of erythrocyte differentiation (GO:0045647)2.75344614

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human4.80635672
2LYL1_20887958_ChIP-Seq_HPC-7_Mouse4.32160460
3SCL_19346495_ChIP-Seq_HPC-7_Human3.68714060
4MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.39582013
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.27873650
6RUNX1_20887958_ChIP-Seq_HPC-7_Mouse3.23132100
7GATA1_22025678_ChIP-Seq_K562_Human3.11389369
8LMO2_20887958_ChIP-Seq_HPC-7_Mouse2.95534313
9GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.95322433
10GATA1_19941826_ChIP-Seq_K562_Human2.86933447
11EZH2_22144423_ChIP-Seq_EOC_Human2.68814371
12STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.66554079
13IRF8_21731497_ChIP-ChIP_J774_Mouse2.64413247
14GATA1_19941827_ChIP-Seq_MEL_Mouse2.59422205
15SRY_22984422_ChIP-ChIP_TESTIS_Rat2.52785932
16HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.47566462
17IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.44989346
18GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.36427567
19GATA2_19941826_ChIP-Seq_K562_Human2.32706887
20PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.23753552
21GBX2_23144817_ChIP-Seq_PC3_Human2.14590633
22MYB_21317192_ChIP-Seq_ERMYB_Mouse2.13213530
23RUNX_20019798_ChIP-Seq_JUKART_Human2.11719583
24GATA2_20887958_ChIP-Seq_HPC-7_Mouse2.11021394
25CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.10875392
26Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.05035809
27TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse2.04875525
28SPI1_23127762_ChIP-Seq_K562_Human2.04767267
29IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.97471240
30GATA1_22383799_ChIP-Seq_G1ME_Mouse1.95074774
31GATA2_21666600_ChIP-Seq_HMVEC_Human1.93604802
32RUNX1_22412390_ChIP-Seq_EML_Mouse1.82093857
33MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.79167072
34FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.74305491
35IRF8_22096565_ChIP-ChIP_GC-B_Human1.72600389
36NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.64657406
37ELK4_26923725_Chip-Seq_MESODERM_Mouse1.59428142
38PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.57974184
39STAT4_19710469_ChIP-ChIP_TH1__Mouse1.56472462
40IRF8_27001747_Chip-Seq_BMDM_Mouse1.55151634
41VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.53515616
42GATA1_19941827_ChIP-Seq_MEL86_Mouse1.50020169
43SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.48907004
44MYB_26560356_Chip-Seq_TH2_Human1.39306250
45SMAD_19615063_ChIP-ChIP_OVARY_Human1.37166845
46SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.35657866
47IKZF1_21737484_ChIP-ChIP_HCT116_Human1.34909508
48HTT_18923047_ChIP-ChIP_STHdh_Human1.34709877
49E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.30051445
50UTX_26944678_Chip-Seq_JUKART_Human1.28112687
51CDX2_19796622_ChIP-Seq_MESCs_Mouse1.21676410
52GATA3_27048872_Chip-Seq_THYMUS_Human1.21163451
53PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.20526509
54SPI1_23547873_ChIP-Seq_NB4_Human1.20343677
55STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.19953159
56EGR1_23403033_ChIP-Seq_LIVER_Mouse1.17696094
57SPI1_20517297_ChIP-Seq_HL60_Human1.16523951
58PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.15178722
59TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.09929373
60GATA2_22383799_ChIP-Seq_G1ME_Mouse1.09800741
61MYB_26560356_Chip-Seq_TH1_Human1.08398121
62NCOR1_26117541_ChIP-Seq_K562_Human1.06716638
63GATA3_26560356_Chip-Seq_TH2_Human1.05950743
64KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.05950255
65SALL4_22934838_ChIP-ChIP_CD34+_Human1.05747023
66POU3F2_20337985_ChIP-ChIP_501MEL_Human1.02009620
67BRD4_27068464_Chip-Seq_AML-cells_Mouse1.00209595
68ETS1_22383799_ChIP-Seq_G1ME_Mouse1.00048719
69SMRT_27268052_Chip-Seq_Bcells_Human0.99408285
70PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.97426473
71EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.95915680
72NRF2_20460467_ChIP-Seq_MEFs_Mouse0.93550587
73NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.93550587
74FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91745047
75TAF15_26573619_Chip-Seq_HEK293_Human0.91110341
76GATA3_21878914_ChIP-Seq_MCF-7_Human0.90086376
77IRF1_19129219_ChIP-ChIP_H3396_Human0.87204668
78VDR_22108803_ChIP-Seq_LS180_Human0.86637522
79EWS_26573619_Chip-Seq_HEK293_Human0.83327180
80TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.82715065
81EZH2_27294783_Chip-Seq_NPCs_Mouse0.82085144
82NANOG_20526341_ChIP-Seq_ESCs_Human0.81719008
83AR_20517297_ChIP-Seq_VCAP_Human0.81535338
84FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.81102596
85IGF1R_20145208_ChIP-Seq_DFB_Human0.80902540
86STAT6_21828071_ChIP-Seq_BEAS2B_Human0.80751899
87CEBPB_22108803_ChIP-Seq_LS180_Human0.80553531
88MAF_26560356_Chip-Seq_TH1_Human0.80181211
89CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.78868532
90FLI1_27457419_Chip-Seq_LIVER_Mouse0.78375175
91BCAT_22108803_ChIP-Seq_LS180_Human0.77958879
92STAT1_20625510_ChIP-Seq_HELA_Human0.76630711
93P53_22387025_ChIP-Seq_ESCs_Mouse0.76108074
94TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.75825601
95HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.75611409
96STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.72370186
97TCF4_18268006_ChIP-ChIP_LS174T_Human0.71601422
98VDR_24763502_ChIP-Seq_THP-1_Human0.70968838
99PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.70452825
100RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.70375802

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005464_abnormal_platelet_physiology9.33218091
2MP0008004_abnormal_stomach_pH4.39009058
3MP0003724_increased_susceptibility_to3.41380482
4MP0000465_gastrointestinal_hemorrhage3.14596013
5MP0001835_abnormal_antigen_presentation3.00774661
6MP0003303_peritoneal_inflammation2.52059194
7MP0005671_abnormal_response_to2.43032633
8MP0003566_abnormal_cell_adhesion2.41468550
9MP0001851_eye_inflammation2.28439512
10MP0000343_altered_response_to2.22916959
11MP0004510_myositis2.18728411
12MP0003763_abnormal_thymus_physiology2.05243334
13MP0000230_abnormal_systemic_arterial2.02763057
14MP0010155_abnormal_intestine_physiology2.00368788
15MP0004130_abnormal_muscle_cell1.97165615
16MP0002148_abnormal_hypersensitivity_rea1.92201627
17MP0002398_abnormal_bone_marrow1.84917356
18MP0001879_abnormal_lymphatic_vessel1.84301087
19MP0002736_abnormal_nociception_after1.79169133
20MP0005000_abnormal_immune_tolerance1.77300653
21MP0005083_abnormal_biliary_tract1.74645751
22MP0000858_altered_metastatic_potential1.70174923
23MP0008775_abnormal_heart_ventricle1.62495870
24MP0004084_abnormal_cardiac_muscle1.60139459
25MP0002723_abnormal_immune_serum1.59999495
26MP0003638_abnormal_response/metabolism_1.58990543
27MP0005084_abnormal_gallbladder_morpholo1.51061996
28MP0005410_abnormal_fertilization1.50201694
29MP0001800_abnormal_humoral_immune1.49937618
30MP0003828_pulmonary_edema1.48042217
31MP0005646_abnormal_pituitary_gland1.42145020
32MP0008872_abnormal_physiological_respon1.41749065
33MP0003436_decreased_susceptibility_to1.39422284
34MP0009763_increased_sensitivity_to1.37286638
35MP0003879_abnormal_hair_cell1.35817237
36MP0002420_abnormal_adaptive_immunity1.35381593
37MP0001819_abnormal_immune_cell1.31705271
38MP0000689_abnormal_spleen_morphology1.31606068
39MP0004134_abnormal_chest_morphology1.31570824
40MP0002452_abnormal_antigen_presenting1.29228128
41MP0002132_abnormal_respiratory_system1.28831606
42MP0002429_abnormal_blood_cell1.28365589
43MP0009785_altered_susceptibility_to1.27109981
44MP0009765_abnormal_xenobiotic_induced1.27088453
45MP0001663_abnormal_digestive_system1.26974775
46MP0005025_abnormal_response_to1.26728388
47MP0010329_abnormal_lipoprotein_level1.24566553
48MP0001533_abnormal_skeleton_physiology1.24290106
49MP0004947_skin_inflammation1.24129996
50MP0001968_abnormal_touch/_nociception1.24098132
51MP0002722_abnormal_immune_system1.23978574
52MP0009764_decreased_sensitivity_to1.23850137
53MP0000716_abnormal_immune_system1.22395153
54MP0005167_abnormal_blood-brain_barrier1.21067842
55MP0009333_abnormal_splenocyte_physiolog1.20544576
56MP0000249_abnormal_blood_vessel1.19569071
57MP0002733_abnormal_thermal_nociception1.17914858
58MP0004036_abnormal_muscle_relaxation1.17450159
59MP0005058_abnormal_lysosome_morphology1.16715918
60MP0003866_abnormal_defecation1.14435313
61MP0001845_abnormal_inflammatory_respons1.12765971
62MP0002638_abnormal_pupillary_reflex1.11640214
63MP0000685_abnormal_immune_system1.09703778
64MP0000703_abnormal_thymus_morphology1.05664805
65MP0001545_abnormal_hematopoietic_system1.03633760
66MP0005397_hematopoietic_system_phenotyp1.03633760
67MP0005387_immune_system_phenotype1.02032416
68MP0001790_abnormal_immune_system1.02032416
69MP0002419_abnormal_innate_immunity0.98565613
70MP0009642_abnormal_blood_homeostasis0.98463861
71MP0008874_decreased_physiological_sensi0.97133559
72MP0001765_abnormal_ion_homeostasis0.96209439
73MP0009697_abnormal_copulation0.88409784
74MP0005666_abnormal_adipose_tissue0.88379844
75MP0008569_lethality_at_weaning0.85609811
76MP0001970_abnormal_pain_threshold0.84994866
77MP0004215_abnormal_myocardial_fiber0.84307614
78MP0003656_abnormal_erythrocyte_physiolo0.84058496
79MP0000015_abnormal_ear_pigmentation0.83413089
80MP0000383_abnormal_hair_follicle0.83250870
81MP0004484_altered_response_of0.81445212
82MP0002653_abnormal_ependyma_morphology0.80742419
83MP0005381_digestive/alimentary_phenotyp0.77041469
84MP0010386_abnormal_urinary_bladder0.75503035
85MP0000490_abnormal_crypts_of0.74220387
86MP0004381_abnormal_hair_follicle0.72253236
87MP0003300_gastrointestinal_ulcer0.69842620
88MP0005174_abnormal_tail_pigmentation0.69274743
89MP0002118_abnormal_lipid_homeostasis0.68191304
90MP0002128_abnormal_blood_circulation0.67029832
91MP0005165_increased_susceptibility_to0.66624884
92MP0003011_delayed_dark_adaptation0.66555826
93MP0005385_cardiovascular_system_phenoty0.65873681
94MP0001544_abnormal_cardiovascular_syste0.65873681
95MP0005535_abnormal_body_temperature0.65583444
96MP0002405_respiratory_system_inflammati0.65258614
97MP0005409_darkened_coat_color0.64012636
98MP0004808_abnormal_hematopoietic_stem0.63832715
99MP0002998_abnormal_bone_remodeling0.62362879
100MP0006036_abnormal_mitochondrial_physio0.60108567

Predicted human phenotypes

RankGene SetZ-score
1Abnormal platelet volume (HP:0011876)9.84537260
2Petechiae (HP:0000967)9.51063795
3Purpura (HP:0000979)8.92302388
4Epistaxis (HP:0000421)7.70063869
5Gingival bleeding (HP:0000225)6.64816454
6Hyperlipoproteinemia (HP:0010980)6.47677445
7Abnormal platelet function (HP:0011869)5.41394311
8Impaired platelet aggregation (HP:0003540)5.41394311
9Spontaneous hematomas (HP:0007420)4.24695875
10Poikilocytosis (HP:0004447)3.87882937
11Dyschromatopsia (HP:0007641)3.66868768
12Conjunctival telangiectasia (HP:0000524)3.63314323
13Acanthocytosis (HP:0001927)3.52253527
14Abnormality of the common coagulation pathway (HP:0010990)3.39811776
15Abnormal pupillary function (HP:0007686)3.36430054
16Increased IgM level (HP:0003496)3.30561388
17Paralysis (HP:0003470)3.29679967
18Abnormality of the heme biosynthetic pathway (HP:0010472)3.21639562
19Bruising susceptibility (HP:0000978)3.17916107
20Abnormality of the vasculature of the conjunctiva (HP:0008054)3.07530612
21Joint swelling (HP:0001386)3.00317922
22Abnormality of lateral ventricle (HP:0030047)2.84294821
23Stomatitis (HP:0010280)2.74198381
24Hepatosplenomegaly (HP:0001433)2.46652492
25Decreased central vision (HP:0007663)2.43287751
26Arterial thrombosis (HP:0004420)2.43129993
27Male infertility (HP:0003251)2.36617700
28Xanthomatosis (HP:0000991)2.33203091
29Autoimmune hemolytic anemia (HP:0001890)2.20973653
30Encephalitis (HP:0002383)2.18698047
31Upper limb muscle weakness (HP:0003484)2.16412335
32Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.13678878
33Papillary thyroid carcinoma (HP:0002895)2.13001933
34Abnormal auditory evoked potentials (HP:0006958)2.12204111
35Abnormality of macrophages (HP:0004311)2.09639009
363-Methylglutaconic aciduria (HP:0003535)2.08634600
37Increased density of long bones (HP:0006392)2.08471028
38Prolonged bleeding time (HP:0003010)11.6725947
39Menorrhagia (HP:0000132)10.5932783
40Increased mean platelet volume (HP:0011877)10.4371992
41Spontaneous abortion (HP:0005268)1.99383176
42Episodic fever (HP:0001954)1.98805748
43Abnormality of iron homeostasis (HP:0011031)1.96880204
44Tinnitus (HP:0000360)1.96528962
45Joint hemorrhage (HP:0005261)1.94295423
46Abnormal ciliary motility (HP:0012262)1.89906216
47Hypoproteinemia (HP:0003075)1.89743758
48Vertigo (HP:0002321)1.85725606
49Abnormality of transition element cation homeostasis (HP:0011030)1.78243081
50Granulocytopenia (HP:0001913)1.73514800
51Thyroid-stimulating hormone excess (HP:0002925)1.72978637
52IgG deficiency (HP:0004315)1.68227958
53Retrobulbar optic neuritis (HP:0100654)1.67757131
54Optic neuritis (HP:0100653)1.67757131
55Increased serum ferritin (HP:0003281)1.67403752
56Arthropathy (HP:0003040)1.66255537
57Ventricular fibrillation (HP:0001663)1.64791172
58Thrombophlebitis (HP:0004418)1.60682315
59Supernumerary ribs (HP:0005815)1.59769478
60Elevated erythrocyte sedimentation rate (HP:0003565)1.59760812
61Vasculitis (HP:0002633)1.57510325
62Hypophosphatemic rickets (HP:0004912)1.57445878
63Dynein arm defect of respiratory motile cilia (HP:0012255)1.56599779
64Absent/shortened dynein arms (HP:0200106)1.56599779
65Infertility (HP:0000789)1.56407143
66Abnormal respiratory motile cilium morphology (HP:0005938)1.56045313
67Abnormal respiratory epithelium morphology (HP:0012253)1.56045313
68Dysautonomia (HP:0002459)1.55712674
69Basal ganglia calcification (HP:0002135)1.54905028
70Thrombocytosis (HP:0001894)1.53856702
71Chronic obstructive pulmonary disease (HP:0006510)1.53113240
72Obstructive lung disease (HP:0006536)1.53113240
73Abnormality of the prostate (HP:0008775)1.52906268
74Pulmonary embolism (HP:0002204)1.50968700
75Aortic aneurysm (HP:0004942)1.50068333
76Cerebral ischemia (HP:0002637)1.49241506
77Hyperthyroidism (HP:0000836)1.48692979
78Enlarged epiphyses (HP:0010580)1.46941746
79Renal Fanconi syndrome (HP:0001994)1.45987980
80Nausea (HP:0002018)1.45897471
81Generalized aminoaciduria (HP:0002909)1.45795203
82Supernumerary bones of the axial skeleton (HP:0009144)1.45712392
83Eosinophilia (HP:0001880)1.44659270
84Congenital sensorineural hearing impairment (HP:0008527)1.43347607
85Abnormal spermatogenesis (HP:0008669)1.42150275
86T lymphocytopenia (HP:0005403)1.41518084
87Panhypogammaglobulinemia (HP:0003139)1.40834132
88Leukocytosis (HP:0001974)1.39433981
89Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.39387386
90Thyroid carcinoma (HP:0002890)1.39137524
91Chest pain (HP:0100749)1.39044276
92Febrile seizures (HP:0002373)1.38470064
93Distal lower limb amyotrophy (HP:0008944)1.38322526
94Intellectual disability, profound (HP:0002187)1.38107830
95Eczematoid dermatitis (HP:0000976)1.38066278
96Abnormality of T cell number (HP:0011839)1.37252362
97Metaphyseal dysplasia (HP:0100255)1.36611116
98Orchitis (HP:0100796)1.35485916
99Myositis (HP:0100614)1.34839889
100Abnormality of binocular vision (HP:0011514)1.32507537

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST44.31096590
2MAP4K24.17887614
3RIPK44.15645205
4BMX3.65686179
5TAOK33.15295758
6VRK13.13733667
7BTK3.01453398
8MYLK2.92537678
9RIPK12.89006025
10FES2.54969097
11TEC2.49017189
12PTK2B2.11115442
13TNIK1.99589412
14SYK1.96706876
15ZAP701.80657675
16BMPR21.77460984
17ILK1.77288801
18CDK81.74305048
19EIF2AK11.74207722
20HCK1.72392555
21TLK11.64895406
22CSF1R1.62901225
23GRK51.61907744
24ZAK1.53345330
25GRK61.48189247
26PIK3CG1.46323437
27TYRO31.43144655
28IRAK31.36787349
29PRPF4B1.33274619
30ADRBK21.30007834
31ACVR1B1.28757677
32TRIM281.28248284
33LYN1.17516998
34TXK1.17411981
35STK31.08436107
36SIK31.08314080
37RET1.02557300
38FGR1.00139514
39ITK0.99948207
40DAPK30.99585791
41PDGFRB0.98538569
42IKBKB0.98440590
43CSK0.96289855
44PIK3CA0.94060755
45PLK30.92924108
46MAPKAPK30.91104896
47TNK20.90169462
48NLK0.90112292
49MAP3K50.89208750
50LMTK20.86358576
51PAK10.82026918
52MAP2K30.79273350
53BLK0.77521490
54JAK10.74695378
55TRPM70.72062712
56PDK10.71158448
57LCK0.70261390
58IRAK10.69034582
59NUAK10.68963578
60ADRBK10.66355364
61PIM10.61106250
62MATK0.60654783
63PRKCQ0.59866225
64PKN20.58808752
65PDPK10.58709486
66BMPR1B0.57786118
67PLK20.56208742
68PIM20.55750918
69STK40.54368593
70PRKACG0.53842583
71MAP2K60.53458693
72PKN10.53193818
73PRKD10.53162619
74MARK30.52102920
75MAPK120.50514274
76PNCK0.48120932
77MAP4K10.45197678
78JAK30.44747588
79EPHA30.44225622
80DAPK20.42908424
81JAK20.41943601
82PRKCE0.41696082
83PRKG10.40177163
84MELK0.40151120
85HIPK20.39965305
86PHKG10.39512151
87PHKG20.39512151
88ERBB20.38024681
89EPHB20.37036496
90STK240.35863627
91LRRK20.35803284
92FYN0.35581199
93TAOK20.35222713
94IGF1R0.33201881
95DYRK1A0.31691110
96MAP3K30.30954754
97ABL20.29167466
98MAPK130.27463884
99DAPK10.26865315
100PRKCB0.26370361

Predicted pathways (KEGG)

RankGene SetZ-score
1Platelet activation_Homo sapiens_hsa046115.54557752
2Pathogenic Escherichia coli infection_Homo sapiens_hsa051303.56576454
3Hematopoietic cell lineage_Homo sapiens_hsa046402.72822536
4SNARE interactions in vesicular transport_Homo sapiens_hsa041302.52939085
5ECM-receptor interaction_Homo sapiens_hsa045121.95231576
6Arachidonic acid metabolism_Homo sapiens_hsa005901.91589634
7Primary immunodeficiency_Homo sapiens_hsa053401.86418252
8Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.85370044
9Mismatch repair_Homo sapiens_hsa034301.84215470
10Alcoholism_Homo sapiens_hsa050341.83569108
11Systemic lupus erythematosus_Homo sapiens_hsa053221.80892527
12Nitrogen metabolism_Homo sapiens_hsa009101.77476054
13Chemokine signaling pathway_Homo sapiens_hsa040621.75886491
14alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.68854326
15Gap junction_Homo sapiens_hsa045401.62275737
16T cell receptor signaling pathway_Homo sapiens_hsa046601.60532279
17Vascular smooth muscle contraction_Homo sapiens_hsa042701.59068587
18Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.58466982
19Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.50679081
20Serotonergic synapse_Homo sapiens_hsa047261.40909173
21Glycerolipid metabolism_Homo sapiens_hsa005611.39027719
22B cell receptor signaling pathway_Homo sapiens_hsa046621.27747264
23Pancreatic secretion_Homo sapiens_hsa049721.23042767
24Shigellosis_Homo sapiens_hsa051311.22837133
25Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.20459294
26Malaria_Homo sapiens_hsa051441.18963764
27Linoleic acid metabolism_Homo sapiens_hsa005911.18432965
28Collecting duct acid secretion_Homo sapiens_hsa049661.15345587
29Phospholipase D signaling pathway_Homo sapiens_hsa040721.10969981
30Viral carcinogenesis_Homo sapiens_hsa052031.08998803
31Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.08113537
32Endocytosis_Homo sapiens_hsa041441.04879110
33Regulation of actin cytoskeleton_Homo sapiens_hsa048101.00791669
34Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.99778317
35Glycerophospholipid metabolism_Homo sapiens_hsa005640.96291237
36Toll-like receptor signaling pathway_Homo sapiens_hsa046200.94372332
37Graft-versus-host disease_Homo sapiens_hsa053320.94180289
38Olfactory transduction_Homo sapiens_hsa047400.87975704
39RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.87206148
40Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.86563196
41Choline metabolism in cancer_Homo sapiens_hsa052310.84234591
42Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.83330819
43Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.80878182
44Non-small cell lung cancer_Homo sapiens_hsa052230.80210307
45Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.80070703
46Pancreatic cancer_Homo sapiens_hsa052120.78522390
47Measles_Homo sapiens_hsa051620.78201376
48Leukocyte transendothelial migration_Homo sapiens_hsa046700.75748938
49Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.75272616
50Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.75088752
51Circadian entrainment_Homo sapiens_hsa047130.71667070
52Fatty acid elongation_Homo sapiens_hsa000620.70670700
53Endometrial cancer_Homo sapiens_hsa052130.70350411
54Fat digestion and absorption_Homo sapiens_hsa049750.70347215
55One carbon pool by folate_Homo sapiens_hsa006700.69256987
56Sulfur metabolism_Homo sapiens_hsa009200.68483985
57Long-term depression_Homo sapiens_hsa047300.67910319
58Osteoclast differentiation_Homo sapiens_hsa043800.67843126
59Phosphatidylinositol signaling system_Homo sapiens_hsa040700.66316834
60Morphine addiction_Homo sapiens_hsa050320.65251815
61Hepatitis B_Homo sapiens_hsa051610.63204114
62Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.62743057
63Asthma_Homo sapiens_hsa053100.62210859
64Allograft rejection_Homo sapiens_hsa053300.61902141
65Calcium signaling pathway_Homo sapiens_hsa040200.61151707
66Focal adhesion_Homo sapiens_hsa045100.60700491
67Autoimmune thyroid disease_Homo sapiens_hsa053200.59693669
68NF-kappa B signaling pathway_Homo sapiens_hsa040640.59275273
69cGMP-PKG signaling pathway_Homo sapiens_hsa040220.59109385
70Cholinergic synapse_Homo sapiens_hsa047250.58171432
71Rap1 signaling pathway_Homo sapiens_hsa040150.58097421
72Jak-STAT signaling pathway_Homo sapiens_hsa046300.57369938
73Glutathione metabolism_Homo sapiens_hsa004800.56726357
74Staphylococcus aureus infection_Homo sapiens_hsa051500.55621860
75Acute myeloid leukemia_Homo sapiens_hsa052210.55461920
76Ras signaling pathway_Homo sapiens_hsa040140.54910918
77Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.53403393
78Intestinal immune network for IgA production_Homo sapiens_hsa046720.52589540
79Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.50154954
80Thyroid cancer_Homo sapiens_hsa052160.49764920
81Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.49210974
82Transcriptional misregulation in cancer_Homo sapiens_hsa052020.48971912
83Apoptosis_Homo sapiens_hsa042100.48898740
84Viral myocarditis_Homo sapiens_hsa054160.48360060
85Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.47477424
86TNF signaling pathway_Homo sapiens_hsa046680.45728417
87Starch and sucrose metabolism_Homo sapiens_hsa005000.44438970
88Phagosome_Homo sapiens_hsa041450.43803156
89Renin secretion_Homo sapiens_hsa049240.41475904
90Melanoma_Homo sapiens_hsa052180.41321923
91Amphetamine addiction_Homo sapiens_hsa050310.41307159
92Glioma_Homo sapiens_hsa052140.40031267
93GABAergic synapse_Homo sapiens_hsa047270.39519135
94Steroid hormone biosynthesis_Homo sapiens_hsa001400.37483728
95Salivary secretion_Homo sapiens_hsa049700.36540297
96Small cell lung cancer_Homo sapiens_hsa052220.36399153
97Pentose and glucuronate interconversions_Homo sapiens_hsa000400.35967195
98Sphingolipid signaling pathway_Homo sapiens_hsa040710.34194956
99Renin-angiotensin system_Homo sapiens_hsa046140.32623870
100Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.32409569

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