TRBV7-5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein neddylation (GO:0045116)8.43530744
2thrombin receptor signaling pathway (GO:0070493)7.79509569
3neutrophil activation involved in immune response (GO:0002283)6.87073737
4triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.71576576
5positive regulation of endothelial cell differentiation (GO:0045603)5.62188228
6regulation of platelet aggregation (GO:0090330)5.52438579
7blood coagulation, intrinsic pathway (GO:0007597)5.51356081
8regulation of platelet activation (GO:0010543)5.48600150
9platelet aggregation (GO:0070527)5.32628858
10adenosine receptor signaling pathway (GO:0001973)5.32351010
11negative regulation of thymocyte apoptotic process (GO:0070244)5.28529054
12negative regulation of heart rate (GO:0010459)5.18813559
13G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)5.09674106
14negative regulation of norepinephrine secretion (GO:0010700)5.02878545
15leukocyte migration involved in inflammatory response (GO:0002523)4.99124747
16regulation of integrin-mediated signaling pathway (GO:2001044)4.85283539
17negative regulation of macrophage derived foam cell differentiation (GO:0010745)4.78933095
18negative regulation of platelet activation (GO:0010544)4.64402469
19purinergic nucleotide receptor signaling pathway (GO:0035590)4.63685433
20low-density lipoprotein particle remodeling (GO:0034374)4.59242326
21fusion of sperm to egg plasma membrane (GO:0007342)4.52490765
22negative regulation of homotypic cell-cell adhesion (GO:0034111)4.49659539
23angiogenesis involved in wound healing (GO:0060055)4.45806423
24mitochondrial calcium ion transport (GO:0006851)4.39791364
25lipoxygenase pathway (GO:0019372)4.33613977
26neutrophil activation (GO:0042119)4.24982326
27positive regulation of mast cell activation (GO:0033005)4.21581755
28negative regulation of T cell apoptotic process (GO:0070233)4.21118348
29regulation of Golgi to plasma membrane protein transport (GO:0042996)4.17012422
30regulation of integrin activation (GO:0033623)4.14592095
31platelet degranulation (GO:0002576)4.13286316
32positive regulation of macrophage differentiation (GO:0045651)4.02144298
33positive regulation of cAMP-mediated signaling (GO:0043950)4.01740068
34positive regulation of Rho protein signal transduction (GO:0035025)3.97836342
35regulation of lipoprotein metabolic process (GO:0050746)3.91280544
36negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.86484131
37purinergic receptor signaling pathway (GO:0035587)3.84070459
38positive regulation of systemic arterial blood pressure (GO:0003084)3.80529607
39regulation of endothelial cell differentiation (GO:0045601)3.76261865
40negative regulation of response to food (GO:0032096)3.75811628
41negative regulation of appetite (GO:0032099)3.75811628
42homotypic cell-cell adhesion (GO:0034109)3.73217201
43G-protein coupled purinergic receptor signaling pathway (GO:0035588)3.73005894
44beta-amyloid metabolic process (GO:0050435)3.69335506
45granulocyte activation (GO:0036230)3.67741958
46Arp2/3 complex-mediated actin nucleation (GO:0034314)3.66966331
47platelet activation (GO:0030168)3.66180709
48platelet formation (GO:0030220)3.65139712
49extracellular fibril organization (GO:0043206)3.63583045
50negative regulation of heart contraction (GO:0045822)3.60796387
51regulation of macrophage derived foam cell differentiation (GO:0010743)3.60392949
52negative regulation of protein localization to cell surface (GO:2000009)3.57890589
53megakaryocyte development (GO:0035855)3.56550458
54positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.41837785
55regulation of homotypic cell-cell adhesion (GO:0034110)3.41611267
56plasma membrane fusion (GO:0045026)3.40625137
57positive regulation of hemostasis (GO:1900048)3.37930104
58positive regulation of blood coagulation (GO:0030194)3.37930104
59regulation of norepinephrine secretion (GO:0014061)3.36487229
60positive regulation of granulocyte differentiation (GO:0030854)3.36337012
61high-density lipoprotein particle remodeling (GO:0034375)3.34165792
62polyamine biosynthetic process (GO:0006596)3.28840091
63regulation of cholesterol efflux (GO:0010874)3.23976015
64negative regulation of neural precursor cell proliferation (GO:2000178)3.22009745
65phospholipid homeostasis (GO:0055091)3.18085580
66termination of G-protein coupled receptor signaling pathway (GO:0038032)3.15816587
67regulation of female receptivity (GO:0045924)3.14471447
68reverse cholesterol transport (GO:0043691)3.12571026
69negative regulation of calcium ion transport into cytosol (GO:0010523)3.12221364
70negative regulation of catecholamine secretion (GO:0033604)3.11599982
71endothelium development (GO:0003158)3.10355829
72fibril organization (GO:0097435)3.09033334
73termination of signal transduction (GO:0023021)3.05644437
74sequestering of actin monomers (GO:0042989)3.04783067
75positive regulation of receptor recycling (GO:0001921)3.03236966
76actin nucleation (GO:0045010)3.03225529
77leukocyte degranulation (GO:0043299)3.03190964
78negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.01597714
79regulation of MHC class II biosynthetic process (GO:0045346)2.99468885
80positive regulation of coagulation (GO:0050820)2.93796421
81regulation of memory T cell differentiation (GO:0043380)2.93638110
82regulation of thymocyte apoptotic process (GO:0070243)2.92989851
83negative regulation of stress fiber assembly (GO:0051497)2.91363029
84autophagic vacuole fusion (GO:0000046)2.91348656
85pyrimidine nucleoside catabolic process (GO:0046135)2.91296106
86pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.91105047
87negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.90369318
88negative regulation of T-helper cell differentiation (GO:0045623)2.90369318
89long-chain fatty acid biosynthetic process (GO:0042759)2.89877772
90cyclooxygenase pathway (GO:0019371)2.86367278
91platelet dense granule organization (GO:0060155)2.86325826
92regulation of regulatory T cell differentiation (GO:0045589)2.86123784
93regulation of mast cell activation (GO:0033003)2.85567785
94fatty acid elongation (GO:0030497)2.84403825
95regulation of megakaryocyte differentiation (GO:0045652)2.83607937
96antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.83478882
97regulation of blood coagulation (GO:0030193)2.78487155
98regulation of hemostasis (GO:1900046)2.78487155
99female mating behavior (GO:0060180)2.76493359
100regulation of mast cell degranulation (GO:0043304)2.73206267

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human4.84737492
2LYL1_20887958_ChIP-Seq_HPC-7_Mouse4.66963412
3SCL_19346495_ChIP-Seq_HPC-7_Human4.00684051
4RUNX1_20887958_ChIP-Seq_HPC-7_Mouse3.48332353
5MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.20332921
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.03581083
7GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.99018326
8GATA1_19941826_ChIP-Seq_K562_Human2.96927060
9TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.94375650
10LMO2_20887958_ChIP-Seq_HPC-7_Mouse2.93349650
11EZH2_22144423_ChIP-Seq_EOC_Human2.91173712
12IRF8_21731497_ChIP-ChIP_J774_Mouse2.62284823
13STAT6_21828071_ChIP-Seq_BEAS2B_Human2.50189989
14GATA2_19941826_ChIP-Seq_K562_Human2.45675555
15GATA2_20887958_ChIP-Seq_HPC-7_Mouse2.43533206
16SRY_22984422_ChIP-ChIP_TESTIS_Rat2.32316440
17HTT_18923047_ChIP-ChIP_STHdh_Human2.31711080
18GATA1_19941827_ChIP-Seq_MEL_Mouse2.31681815
19STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.31107926
20Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.18567306
21GATA2_21666600_ChIP-Seq_HMVEC_Human2.10891997
22TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse2.02195765
23SPI1_23127762_ChIP-Seq_K562_Human2.00364867
24MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.99288586
25GATA1_22383799_ChIP-Seq_G1ME_Mouse1.96725324
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.96568946
27IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.96457795
28IKZF1_21737484_ChIP-ChIP_HCT116_Human1.95343043
29ELK4_26923725_Chip-Seq_MESODERM_Mouse1.91305673
30RUNX1_22412390_ChIP-Seq_EML_Mouse1.84678605
31MYB_21317192_ChIP-Seq_ERMYB_Mouse1.84678277
32HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.84349384
33PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.83432676
34CDX2_19796622_ChIP-Seq_MESCs_Mouse1.73237614
35RUNX_20019798_ChIP-Seq_JUKART_Human1.69155628
36GBX2_23144817_ChIP-Seq_PC3_Human1.61544506
37IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.57658571
38IRF8_27001747_Chip-Seq_BMDM_Mouse1.54275622
39NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.51809758
40GATA1_22025678_ChIP-Seq_K562_Human1.49138908
41GATA1_19941827_ChIP-Seq_MEL86_Mouse1.48011974
42TAF15_26573619_Chip-Seq_HEK293_Human1.47333984
43SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.39326613
44SPI1_20517297_ChIP-Seq_HL60_Human1.39212481
45PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.33952741
46FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.27116285
47GATA2_22383799_ChIP-Seq_G1ME_Mouse1.24637662
48UTX_26944678_Chip-Seq_JUKART_Human1.20504837
49PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.17694101
50SALL4_22934838_ChIP-ChIP_CD34+_Human1.12046915
51ETS1_22383799_ChIP-Seq_G1ME_Mouse1.11550872
52MYB_26560356_Chip-Seq_TH2_Human1.10895209
53SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.09938292
54STAT4_19710469_ChIP-ChIP_TH1__Mouse1.08008320
55BCAT_22108803_ChIP-Seq_LS180_Human1.06714719
56PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05578974
57E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.05151018
58GATA3_27048872_Chip-Seq_THYMUS_Human1.05150946
59KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.05018512
60VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.02143529
61POU3F2_20337985_ChIP-ChIP_501MEL_Human1.01291224
62NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.00214891
63NRF2_20460467_ChIP-Seq_MEFs_Mouse1.00214891
64IGF1R_20145208_ChIP-Seq_DFB_Human1.00122342
65NCOR1_26117541_ChIP-Seq_K562_Human0.97549508
66EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.97428177
67STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.96782822
68NANOG_20526341_ChIP-Seq_ESCs_Human0.96627917
69GATA3_21878914_ChIP-Seq_MCF-7_Human0.93625863
70STAT1_20625510_ChIP-Seq_HELA_Human0.92219586
71SPI1_23547873_ChIP-Seq_NB4_Human0.89954491
72CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.89874358
73LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.88334720
74JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.88054699
75FLI1_27457419_Chip-Seq_LIVER_Mouse0.88033670
76FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88007908
77ERG_20517297_ChIP-Seq_VCAP_Human0.87893735
78CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.84882087
79SOX2_19829295_ChIP-Seq_ESCs_Human0.83714694
80NANOG_19829295_ChIP-Seq_ESCs_Human0.83714694
81CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.82721771
82GATA3_26560356_Chip-Seq_TH2_Human0.82704512
83TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.82541026
84EGR1_23403033_ChIP-Seq_LIVER_Mouse0.81484369
85BRD4_27068464_Chip-Seq_AML-cells_Mouse0.81368827
86UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.81083631
87TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.80916591
88PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.80676239
89NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.80519614
90JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.79022419
91MYB_26560356_Chip-Seq_TH1_Human0.78478027
92OCT1_27270436_Chip-Seq_PROSTATE_Human0.77636963
93PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.77198881
94TCF4_18268006_ChIP-ChIP_LS174T_Human0.76854975
95FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.76626454
96TDRD3_21172665_ChIP-Seq_MCF-7_Human0.74904176
97AR_20517297_ChIP-Seq_VCAP_Human0.74598724
98ESR1_20079471_ChIP-ChIP_T-47D_Human0.74167240
99CEBPB_22108803_ChIP-Seq_LS180_Human0.73736657
100YY1_22570637_ChIP-Seq_MALME-3M_Human0.73572234

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005464_abnormal_platelet_physiology9.56303334
2MP0008004_abnormal_stomach_pH5.53138988
3MP0003724_increased_susceptibility_to3.54959249
4MP0000465_gastrointestinal_hemorrhage3.33089558
5MP0005671_abnormal_response_to2.69437414
6MP0005083_abnormal_biliary_tract2.42319149
7MP0001835_abnormal_antigen_presentation2.36953981
8MP0002736_abnormal_nociception_after2.32595882
9MP0004510_myositis2.31990600
10MP0000230_abnormal_systemic_arterial2.14486654
11MP0000343_altered_response_to2.10841596
12MP0008872_abnormal_physiological_respon2.08437839
13MP0001879_abnormal_lymphatic_vessel2.05258926
14MP0005410_abnormal_fertilization2.02112100
15MP0005646_abnormal_pituitary_gland1.89608799
16MP0003638_abnormal_response/metabolism_1.88718195
17MP0003303_peritoneal_inflammation1.86361522
18MP0010155_abnormal_intestine_physiology1.84670802
19MP0005167_abnormal_blood-brain_barrier1.84574893
20MP0004084_abnormal_cardiac_muscle1.80819651
21MP0002148_abnormal_hypersensitivity_rea1.78981248
22MP0008775_abnormal_heart_ventricle1.75807689
23MP0003566_abnormal_cell_adhesion1.72609097
24MP0005084_abnormal_gallbladder_morpholo1.63709478
25MP0005000_abnormal_immune_tolerance1.63492061
26MP0004036_abnormal_muscle_relaxation1.53689861
27MP0001851_eye_inflammation1.52170067
28MP0001968_abnormal_touch/_nociception1.51493575
29MP0002398_abnormal_bone_marrow1.51436341
30MP0005058_abnormal_lysosome_morphology1.48780007
31MP0003879_abnormal_hair_cell1.47273780
32MP0002733_abnormal_thermal_nociception1.42255236
33MP0003828_pulmonary_edema1.40384304
34MP0001545_abnormal_hematopoietic_system1.38190211
35MP0005397_hematopoietic_system_phenotyp1.38190211
36MP0004130_abnormal_muscle_cell1.34636192
37MP0000249_abnormal_blood_vessel1.32409723
38MP0009763_increased_sensitivity_to1.30069975
39MP0002723_abnormal_immune_serum1.29353379
40MP0002653_abnormal_ependyma_morphology1.23922903
41MP0003436_decreased_susceptibility_to1.22401359
42MP0004947_skin_inflammation1.19364287
43MP0001533_abnormal_skeleton_physiology1.18309338
44MP0002452_abnormal_antigen_presenting1.18306656
45MP0001800_abnormal_humoral_immune1.18138673
46MP0009697_abnormal_copulation1.17770158
47MP0001663_abnormal_digestive_system1.16246532
48MP0002132_abnormal_respiratory_system1.15989543
49MP0000689_abnormal_spleen_morphology1.14996863
50MP0002429_abnormal_blood_cell1.11425698
51MP0002420_abnormal_adaptive_immunity1.11344759
52MP0010329_abnormal_lipoprotein_level1.11114491
53MP0003866_abnormal_defecation1.10174229
54MP0001819_abnormal_immune_cell1.08778548
55MP0001970_abnormal_pain_threshold1.04263788
56MP0002722_abnormal_immune_system1.02719439
57MP0001845_abnormal_inflammatory_respons1.01266918
58MP0005025_abnormal_response_to0.99289402
59MP0000716_abnormal_immune_system0.99184894
60MP0000858_altered_metastatic_potential0.97842452
61MP0002102_abnormal_ear_morphology0.97199652
62MP0009642_abnormal_blood_homeostasis0.96338470
63MP0003136_yellow_coat_color0.96137322
64MP0008874_decreased_physiological_sensi0.96113827
65MP0004215_abnormal_myocardial_fiber0.96072026
66MP0002419_abnormal_innate_immunity0.95786052
67MP0009765_abnormal_xenobiotic_induced0.94339149
68MP0003763_abnormal_thymus_physiology0.91923626
69MP0000685_abnormal_immune_system0.91574058
70MP0006036_abnormal_mitochondrial_physio0.90316301
71MP0001765_abnormal_ion_homeostasis0.89658719
72MP0005387_immune_system_phenotype0.88283417
73MP0001790_abnormal_immune_system0.88283417
74MP0010368_abnormal_lymphatic_system0.88079215
75MP0004381_abnormal_hair_follicle0.86948389
76MP0009764_decreased_sensitivity_to0.86244203
77MP0005645_abnormal_hypothalamus_physiol0.83671263
78MP0005023_abnormal_wound_healing0.83277126
79MP0004142_abnormal_muscle_tone0.82306125
80MP0001664_abnormal_digestion0.81821231
81MP0009333_abnormal_splenocyte_physiolog0.80767519
82MP0006276_abnormal_autonomic_nervous0.80294084
83MP0000015_abnormal_ear_pigmentation0.79322113
84MP0010386_abnormal_urinary_bladder0.76789828
85MP0009785_altered_susceptibility_to0.74118693
86MP0002998_abnormal_bone_remodeling0.73804677
87MP0005165_increased_susceptibility_to0.73439881
88MP0006138_congestive_heart_failure0.72839430
89MP0000703_abnormal_thymus_morphology0.71148889
90MP0003656_abnormal_erythrocyte_physiolo0.70945791
91MP0003075_altered_response_to0.69305229
92MP0000383_abnormal_hair_follicle0.68945519
93MP0005381_digestive/alimentary_phenotyp0.68409078
94MP0005409_darkened_coat_color0.67980242
95MP0002972_abnormal_cardiac_muscle0.65169421
96MP0002118_abnormal_lipid_homeostasis0.64886865
97MP0003806_abnormal_nucleotide_metabolis0.64601342
98MP0005385_cardiovascular_system_phenoty0.63945153
99MP0001544_abnormal_cardiovascular_syste0.63945153
100MP0002405_respiratory_system_inflammati0.62517245

Predicted human phenotypes

RankGene SetZ-score
1Petechiae (HP:0000967)9.68894825
2Abnormal platelet volume (HP:0011876)9.68041899
3Purpura (HP:0000979)8.98421275
4Epistaxis (HP:0000421)7.63380508
5Hyperlipoproteinemia (HP:0010980)6.47490577
6Gingival bleeding (HP:0000225)6.44535876
7Abnormal platelet function (HP:0011869)5.48903084
8Impaired platelet aggregation (HP:0003540)5.48903084
9Dyschromatopsia (HP:0007641)4.50603252
10Spontaneous hematomas (HP:0007420)4.09357590
11Poikilocytosis (HP:0004447)4.03573347
12Acanthocytosis (HP:0001927)3.99839290
13Abnormality of the common coagulation pathway (HP:0010990)3.57548081
14Bruising susceptibility (HP:0000978)3.39846352
15Conjunctival telangiectasia (HP:0000524)3.39241345
16Abnormal pupillary function (HP:0007686)3.35031794
17Paralysis (HP:0003470)3.31493301
18Abnormality of the heme biosynthetic pathway (HP:0010472)3.11368118
19Abnormality of the vasculature of the conjunctiva (HP:0008054)2.99895879
20Abnormal auditory evoked potentials (HP:0006958)2.87311657
21Abnormality of macrophages (HP:0004311)2.74263758
22Hepatosplenomegaly (HP:0001433)2.73914470
23Increased density of long bones (HP:0006392)2.59291184
24Generalized aminoaciduria (HP:0002909)2.57846316
253-Methylglutaconic aciduria (HP:0003535)2.49000316
26Male infertility (HP:0003251)2.48742242
27Xanthomatosis (HP:0000991)2.48619474
28Joint hemorrhage (HP:0005261)2.46927548
29Joint swelling (HP:0001386)2.46845971
30Decreased central vision (HP:0007663)2.40228108
31Stomatitis (HP:0010280)2.39496184
32Autoimmune hemolytic anemia (HP:0001890)2.39190453
33Abnormality of lateral ventricle (HP:0030047)2.38451729
34Increased IgM level (HP:0003496)2.38431452
35Tinnitus (HP:0000360)2.20450628
36Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.18821157
37Upper limb muscle weakness (HP:0003484)2.17330314
38Spontaneous abortion (HP:0005268)2.13634999
39Abnormal ciliary motility (HP:0012262)2.07926885
40Aplastic anemia (HP:0001915)2.07666055
41Arterial thrombosis (HP:0004420)2.03328111
42Abnormality of iron homeostasis (HP:0011031)2.00616812
43Prolonged bleeding time (HP:0003010)11.5388848
44Menorrhagia (HP:0000132)10.5281981
45Increased mean platelet volume (HP:0011877)10.2733164
46Ventricular fibrillation (HP:0001663)1.94576010
47Thyroid-stimulating hormone excess (HP:0002925)1.89236876
48Encephalitis (HP:0002383)1.87217398
49Polycythemia (HP:0001901)1.86767846
50Myocardial infarction (HP:0001658)1.83644345
51Tongue fasciculations (HP:0001308)1.83043969
52Dynein arm defect of respiratory motile cilia (HP:0012255)1.81555087
53Absent/shortened dynein arms (HP:0200106)1.81555087
54Chronic obstructive pulmonary disease (HP:0006510)1.81076520
55Obstructive lung disease (HP:0006536)1.81076520
56Nausea (HP:0002018)1.80583372
57Dysautonomia (HP:0002459)1.78403342
58Abnormality of transition element cation homeostasis (HP:0011030)1.77499071
59Papillary thyroid carcinoma (HP:0002895)1.77483697
60Episodic fever (HP:0001954)1.77087182
61Hyperthyroidism (HP:0000836)1.71798751
62Abnormal respiratory motile cilium morphology (HP:0005938)1.71212809
63Abnormal respiratory epithelium morphology (HP:0012253)1.71212809
64Hypophosphatemic rickets (HP:0004912)1.70669596
65Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.68427376
66Vertigo (HP:0002321)1.64702128
67Thrombocytosis (HP:0001894)1.64434638
68Muscle fibrillation (HP:0010546)1.64332306
69Renal Fanconi syndrome (HP:0001994)1.61648444
70Abnormality of the prostate (HP:0008775)1.61158098
71Infertility (HP:0000789)1.61103606
72Abnormal spermatogenesis (HP:0008669)1.59490463
73Chest pain (HP:0100749)1.56962546
74Arthropathy (HP:0003040)1.55608013
75Increased serum ferritin (HP:0003281)1.54730077
76Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.54593853
77Basal ganglia calcification (HP:0002135)1.52059375
78Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.49295224
79Exertional dyspnea (HP:0002875)1.46542177
80Distal lower limb amyotrophy (HP:0008944)1.46222749
81Leukocytosis (HP:0001974)1.45908304
82Hypomagnesemia (HP:0002917)1.43221509
83Biliary tract neoplasm (HP:0100574)1.42837635
84T lymphocytopenia (HP:0005403)1.41353258
85Acute hepatic failure (HP:0006554)1.38666924
86Thrombophlebitis (HP:0004418)1.38456230
87Central scotoma (HP:0000603)1.35992504
88Testicular neoplasm (HP:0010788)1.35449473
89Abnormality of magnesium homeostasis (HP:0004921)1.33591767
90Abnormality of T cell number (HP:0011839)1.33469334
91Hypoproteinemia (HP:0003075)1.32707278
92Cerebral hemorrhage (HP:0001342)1.32679821
93Autoimmune thrombocytopenia (HP:0001973)1.31784318
94Pigmentary retinal degeneration (HP:0001146)1.31474559
95Leiomyosarcoma (HP:0100243)1.31400627
96Uterine leiomyosarcoma (HP:0002891)1.31400627
97Granulocytopenia (HP:0001913)1.30802948
98IgG deficiency (HP:0004315)1.29227006
99Polyphagia (HP:0002591)1.28791837
100Abnormality of the costochondral junction (HP:0000919)1.28620498

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.62368552
2TAOK34.62319219
3MST44.47035427
4BMX3.77094527
5MYLK3.51629693
6TXK3.34519885
7BTK2.82624018
8TEC2.78398518
9PTK2B2.39880852
10CSF1R2.27774716
11ZAP702.26350578
12GRK52.21273765
13MAP3K122.20581683
14EIF2AK12.17103564
15SYK2.15872521
16MAP3K111.96745257
17PIK3CG1.88968212
18ILK1.75332972
19BMPR21.71822909
20GRK61.67853842
21ADRBK21.56028311
22MAP2K31.54103313
23FGR1.49115287
24FES1.48579157
25MAP4K11.44286375
26TESK21.36669927
27MAPKAPK31.21896873
28TNK21.20885243
29HCK1.19462373
30STK31.18237002
31LYN1.18216217
32MAP3K51.17688206
33KDR1.16695216
34BLK1.15796406
35LMTK21.13874556
36DAPK31.12983889
37IKBKB1.09531397
38PLK21.01127911
39SCYL21.00901706
40ITK1.00868013
41PAK11.00329592
42MARK30.88269058
43CSK0.83260651
44TNIK0.79880569
45NLK0.79519090
46ADRBK10.79305926
47MATK0.76222671
48PNCK0.76054117
49PIM20.75450591
50NUAK10.69760214
51ZAK0.68269189
52TLK10.66627320
53DAPK20.63879627
54ACVR1B0.63215175
55DAPK10.59320507
56MAPK120.58665084
57LCK0.58290803
58TRIM280.56672370
59PRKD10.56129085
60PDK10.53326730
61RET0.51585314
62IRAK10.51290748
63ERBB20.49282638
64STK240.49128628
65FER0.48750305
66PKN10.48691879
67GRK10.48482297
68FYN0.47045950
69MAPK130.45542196
70WNK40.45269003
71TAOK20.44483468
72IKBKE0.44267804
73MAP2K40.43178109
74JAK30.42632599
75EPHB20.42094975
76EPHA30.41788798
77MINK10.41353922
78PRKACG0.40716607
79PRKCQ0.40281076
80MAP3K30.40144101
81MAP3K10.39768411
82IGF1R0.39517327
83SIK30.38046948
84PDGFRB0.37890738
85PRKG10.35764372
86PIM10.34488361
87MAPK150.33174696
88PRKCA0.31504691
89PDPK10.29612859
90PRKCB0.29099331
91STK40.27931121
92DYRK1B0.27641042
93MAP4K20.27157554
94SRC0.25073719
95TESK10.24903029
96STK390.24576488
97MAP2K10.24548052
98IRAK40.23562111
99ROCK10.23501954
100CDK80.23498240

Predicted pathways (KEGG)

RankGene SetZ-score
1Platelet activation_Homo sapiens_hsa046115.49828517
2Pathogenic Escherichia coli infection_Homo sapiens_hsa051303.56095011
3SNARE interactions in vesicular transport_Homo sapiens_hsa041303.15633115
4Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007603.09426651
5Hematopoietic cell lineage_Homo sapiens_hsa046402.82257237
6Nitrogen metabolism_Homo sapiens_hsa009102.39911313
7Arachidonic acid metabolism_Homo sapiens_hsa005902.27582043
8ECM-receptor interaction_Homo sapiens_hsa045122.23216675
9Primary immunodeficiency_Homo sapiens_hsa053402.00204583
10Chemokine signaling pathway_Homo sapiens_hsa040621.81596228
11Serotonergic synapse_Homo sapiens_hsa047261.74178007
12Vascular smooth muscle contraction_Homo sapiens_hsa042701.65287057
13Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.64652227
14alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.53664693
15Gap junction_Homo sapiens_hsa045401.53489279
16Systemic lupus erythematosus_Homo sapiens_hsa053221.49639842
17Collecting duct acid secretion_Homo sapiens_hsa049661.45121821
18Shigellosis_Homo sapiens_hsa051311.42875744
19Alcoholism_Homo sapiens_hsa050341.41225355
20Endocytosis_Homo sapiens_hsa041441.37094916
21Malaria_Homo sapiens_hsa051441.33376264
22T cell receptor signaling pathway_Homo sapiens_hsa046601.32171413
23Pancreatic secretion_Homo sapiens_hsa049721.22928600
24Linoleic acid metabolism_Homo sapiens_hsa005911.22160155
25Phototransduction_Homo sapiens_hsa047441.21759839
26Olfactory transduction_Homo sapiens_hsa047401.20842862
27Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.16454324
28Fatty acid elongation_Homo sapiens_hsa000621.15205468
29Glycerolipid metabolism_Homo sapiens_hsa005611.13272277
30Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.12571886
31Regulation of actin cytoskeleton_Homo sapiens_hsa048101.11604832
32B cell receptor signaling pathway_Homo sapiens_hsa046621.09283548
33Leukocyte transendothelial migration_Homo sapiens_hsa046701.07850510
34Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.07771807
35Morphine addiction_Homo sapiens_hsa050321.03161162
36Fatty acid biosynthesis_Homo sapiens_hsa000611.00594651
37Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.99490737
38Steroid hormone biosynthesis_Homo sapiens_hsa001400.91036714
39Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.91011476
40Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.88683529
41Circadian entrainment_Homo sapiens_hsa047130.85616790
42Phospholipase D signaling pathway_Homo sapiens_hsa040720.85475677
43Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.83969262
44Toll-like receptor signaling pathway_Homo sapiens_hsa046200.83373681
45Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.82475431
46Sulfur metabolism_Homo sapiens_hsa009200.81565736
47Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.79946458
48Glutathione metabolism_Homo sapiens_hsa004800.77386857
49Phagosome_Homo sapiens_hsa041450.77070761
50Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.76271590
51Starch and sucrose metabolism_Homo sapiens_hsa005000.74149363
52GABAergic synapse_Homo sapiens_hsa047270.71448432
53Calcium signaling pathway_Homo sapiens_hsa040200.70430624
54Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.70293588
55Fat digestion and absorption_Homo sapiens_hsa049750.69203035
56Ras signaling pathway_Homo sapiens_hsa040140.68419861
57Rap1 signaling pathway_Homo sapiens_hsa040150.68092278
58Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.68018134
59Long-term depression_Homo sapiens_hsa047300.67030303
60Glycerophospholipid metabolism_Homo sapiens_hsa005640.64096310
61Osteoclast differentiation_Homo sapiens_hsa043800.63751795
62Viral carcinogenesis_Homo sapiens_hsa052030.63551093
63Focal adhesion_Homo sapiens_hsa045100.63154169
64Regulation of autophagy_Homo sapiens_hsa041400.61313723
65Allograft rejection_Homo sapiens_hsa053300.61089712
66Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.58479332
67Graft-versus-host disease_Homo sapiens_hsa053320.55604020
68Choline metabolism in cancer_Homo sapiens_hsa052310.55000880
69Autoimmune thyroid disease_Homo sapiens_hsa053200.52002425
70Renin-angiotensin system_Homo sapiens_hsa046140.51906449
71Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.50117354
72Renin secretion_Homo sapiens_hsa049240.49645794
73Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.47986640
74Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.47565078
75Pancreatic cancer_Homo sapiens_hsa052120.47253288
76Pentose and glucuronate interconversions_Homo sapiens_hsa000400.45659525
77Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.45565627
78Staphylococcus aureus infection_Homo sapiens_hsa051500.45136629
79Phosphatidylinositol signaling system_Homo sapiens_hsa040700.44217306
80RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.43718205
81Chemical carcinogenesis_Homo sapiens_hsa052040.43655363
82Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.43475764
83Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.43304935
84Dilated cardiomyopathy_Homo sapiens_hsa054140.42651964
85Cholinergic synapse_Homo sapiens_hsa047250.42438637
86Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.41062999
87Asthma_Homo sapiens_hsa053100.40390218
88Rheumatoid arthritis_Homo sapiens_hsa053230.40239996
89Salmonella infection_Homo sapiens_hsa051320.37959551
90Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.37790268
91Primary bile acid biosynthesis_Homo sapiens_hsa001200.36968366
92Melanoma_Homo sapiens_hsa052180.36394456
93Intestinal immune network for IgA production_Homo sapiens_hsa046720.36240618
94Complement and coagulation cascades_Homo sapiens_hsa046100.36219033
95Small cell lung cancer_Homo sapiens_hsa052220.35382161
96Jak-STAT signaling pathway_Homo sapiens_hsa046300.34773271
97cGMP-PKG signaling pathway_Homo sapiens_hsa040220.33381645
98Apoptosis_Homo sapiens_hsa042100.33314750
99Amoebiasis_Homo sapiens_hsa051460.31852788
100Synaptic vesicle cycle_Homo sapiens_hsa047210.30880573

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »