TRBV7-6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1T cell migration (GO:0072678)6.72028070
2regulation of B cell receptor signaling pathway (GO:0050855)6.12035427
3cellular response to zinc ion (GO:0071294)5.78549093
4activated T cell proliferation (GO:0050798)5.65635922
5protein K63-linked deubiquitination (GO:0070536)5.60540827
6cellular response to ATP (GO:0071318)5.59352451
7positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.52429518
8negative regulation of execution phase of apoptosis (GO:1900118)5.39148151
9positive T cell selection (GO:0043368)5.18421036
10antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.13577638
11positive thymic T cell selection (GO:0045059)4.99053461
12negative T cell selection (GO:0043383)4.88784462
13thymic T cell selection (GO:0045061)4.81643031
14negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.77233695
15negative regulation of cell killing (GO:0031342)4.77233695
16GDP-mannose metabolic process (GO:0019673)4.65385440
17glomerular visceral epithelial cell development (GO:0072015)4.50462553
18T cell selection (GO:0045058)4.41266830
19cellular response to interleukin-15 (GO:0071350)4.40859742
20positive regulation of keratinocyte differentiation (GO:0045618)4.39672685
21positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.39114428
22antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.37012145
23protein K11-linked deubiquitination (GO:0035871)4.28841790
24programmed necrotic cell death (GO:0097300)4.25232761
25regulation of antigen receptor-mediated signaling pathway (GO:0050854)4.21832484
26G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)4.12122767
27pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.11704075
28response to interleukin-15 (GO:0070672)4.11127525
29protein K48-linked deubiquitination (GO:0071108)4.10825298
30negative regulation of interleukin-12 production (GO:0032695)3.97680775
31positive regulation of gamma-delta T cell activation (GO:0046645)3.95545793
32glomerular epithelial cell development (GO:0072310)3.95237021
33antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.94514860
34necrotic cell death (GO:0070265)3.91462757
35necroptotic process (GO:0070266)3.91428090
36negative thymic T cell selection (GO:0045060)3.89340080
37antigen processing and presentation of endogenous antigen (GO:0019883)3.80732697
38regulation of B cell differentiation (GO:0045577)3.77065646
39positive regulation of T cell mediated cytotoxicity (GO:0001916)3.76853419
40regulation of defense response to virus by host (GO:0050691)3.75263453
41regulation of isotype switching to IgG isotypes (GO:0048302)3.75085679
42maturation of SSU-rRNA (GO:0030490)3.74292158
43positive regulation of endothelial cell differentiation (GO:0045603)3.73336294
44regulation of interleukin-2 biosynthetic process (GO:0045076)3.72940886
45dolichol-linked oligosaccharide biosynthetic process (GO:0006488)3.65358702
46B cell receptor signaling pathway (GO:0050853)3.62843610
47pyrimidine nucleotide catabolic process (GO:0006244)3.62157442
48cytokine biosynthetic process (GO:0042089)3.58279607
49regulation of T cell receptor signaling pathway (GO:0050856)3.56217749
50negative regulation of T cell mediated immunity (GO:0002710)3.56165690
51regulation of regulatory T cell differentiation (GO:0045589)3.55045934
52lymphocyte migration (GO:0072676)3.53987843
53positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.52911876
54regulation of T cell mediated cytotoxicity (GO:0001914)3.51946513
55sequestering of metal ion (GO:0051238)3.49760500
56UDP-N-acetylglucosamine metabolic process (GO:0006047)3.47626091
57regulation of natural killer cell mediated immunity (GO:0002715)3.46105849
58regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.46105849
59regulation of interferon-beta biosynthetic process (GO:0045357)3.44525952
60lymphocyte chemotaxis (GO:0048247)3.41924811
61T cell mediated immunity (GO:0002456)3.41419575
62positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.40318731
63interferon-gamma production (GO:0032609)3.38631028
64positive regulation of guanylate cyclase activity (GO:0031284)3.37653304
65negative regulation of T cell apoptotic process (GO:0070233)3.37611286
66regulation of leukocyte mediated cytotoxicity (GO:0001910)3.34355156
67negative regulation of lymphocyte mediated immunity (GO:0002707)3.34212240
68N-acetylneuraminate metabolic process (GO:0006054)3.33728384
69antigen processing and presentation via MHC class Ib (GO:0002475)3.32963019
70positive regulation of B cell differentiation (GO:0045579)3.31148490
71base-excision repair, AP site formation (GO:0006285)3.31018566
72negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.28498867
73positive regulation of natural killer cell mediated immunity (GO:0002717)3.24952623
74regulation of T cell tolerance induction (GO:0002664)3.22570619
75negative regulation of T cell receptor signaling pathway (GO:0050860)3.22344516
76cytolysis (GO:0019835)3.21567557
77negative regulation of leukocyte mediated immunity (GO:0002704)3.21517658
78positive regulation of cell killing (GO:0031343)3.20642348
79T cell receptor signaling pathway (GO:0050852)3.19996653
80lipopolysaccharide metabolic process (GO:0008653)3.19414085
81regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.18373186
82antigen receptor-mediated signaling pathway (GO:0050851)3.16822908
83leukocyte aggregation (GO:0070486)3.16577234
84positive regulation of calcium-mediated signaling (GO:0050850)3.16397365
85T-helper cell differentiation (GO:0042093)3.16200207
86CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.16200207
87chemokine-mediated signaling pathway (GO:0070098)3.15130581
88mannosylation (GO:0097502)3.13998125
89negative regulation of macroautophagy (GO:0016242)3.11517621
90regulation of gamma-delta T cell differentiation (GO:0045586)3.09692151
91receptor guanylyl cyclase signaling pathway (GO:0007168)3.08282852
92regulation of guanylate cyclase activity (GO:0031282)3.06405170
93response to type I interferon (GO:0034340)3.05259012
94type I interferon signaling pathway (GO:0060337)3.04292146
95cellular response to type I interferon (GO:0071357)3.04292146
96regulation of cell killing (GO:0031341)3.03541784
97Arp2/3 complex-mediated actin nucleation (GO:0034314)3.03465225
98negative regulation of type I interferon production (GO:0032480)3.02144228
99regulation of chronic inflammatory response (GO:0002676)3.01776347
100macrophage chemotaxis (GO:0048246)2.98273843

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse5.52440410
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.13270530
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.47292907
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.26054725
5STAT6_21828071_ChIP-Seq_BEAS2B_Human4.17884357
6BP1_19119308_ChIP-ChIP_Hs578T_Human4.13373173
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.35348016
8RUNX_20019798_ChIP-Seq_JUKART_Human3.21427403
9ELF1_17652178_ChIP-ChIP_JURKAT_Human2.97103990
10STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.75397942
11MYB_26560356_Chip-Seq_TH2_Human2.71034239
12RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.61897330
13MAF_26560356_Chip-Seq_TH1_Human2.60713694
14E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.52496118
15ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.50399554
16IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.47806439
17UTX_26944678_Chip-Seq_JUKART_Human2.42337328
18FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.31692072
19PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.27319022
20MYB_26560356_Chip-Seq_TH1_Human2.22909502
21LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.15191780
22NOTCH1_21737748_ChIP-Seq_TLL_Human2.13109955
23MAF_26560356_Chip-Seq_TH2_Human2.07390878
24GATA3_27048872_Chip-Seq_THYMUS_Human2.05355226
25KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.03201554
26KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.03201554
27KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.03201554
28MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.94466291
29STAT4_19710469_ChIP-ChIP_TH1__Mouse1.93456111
30GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.88443051
31SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.84015198
32MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.75519189
33E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.75331735
34VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.72964222
35FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.57745454
36LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.52568874
37IRF8_27001747_Chip-Seq_BMDM_Mouse1.47912427
38BCOR_27268052_Chip-Seq_Bcells_Human1.41897531
39CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.41450963
40SPI1_23547873_ChIP-Seq_NB4_Human1.30285841
41RUNX1_22412390_ChIP-Seq_EML_Mouse1.28629674
42IRF8_21731497_ChIP-ChIP_J774_Mouse1.27707292
43GATA3_26560356_Chip-Seq_TH2_Human1.26536774
44CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.26368828
45SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.21608612
46EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.21413911
47TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.20407921
48VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.20283495
49SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.15786889
50RAC3_21632823_ChIP-Seq_H3396_Human1.15020575
51SA1_27219007_Chip-Seq_Bcells_Human1.13759732
52E2F1_20622854_ChIP-Seq_HELA_Human1.13417257
53BRD4_27068464_Chip-Seq_AML-cells_Mouse1.11718560
54RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.11611006
55OCT4_20526341_ChIP-Seq_ESCs_Human1.10477085
56RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.10408885
57TAF2_19829295_ChIP-Seq_ESCs_Human1.09629864
58RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.08798290
59SPI1_20517297_ChIP-Seq_HL60_Human1.08779244
60CTCF_26484167_Chip-Seq_Bcells_Mouse1.08192912
61DROSHA_22980978_ChIP-Seq_HELA_Human1.07997418
62AR_21572438_ChIP-Seq_LNCaP_Human1.06363234
63NANOG_20526341_ChIP-Seq_ESCs_Human1.05664731
64NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.04060589
65PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98995738
66BCL6_27268052_Chip-Seq_Bcells_Human0.97466527
67VDR_23849224_ChIP-Seq_CD4+_Human0.97177467
68CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.96413706
69SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.94300455
70ZNF274_21170338_ChIP-Seq_K562_Hela0.92723729
71ER_23166858_ChIP-Seq_MCF-7_Human0.92552498
72CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91929289
73CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.91550883
74P300_27268052_Chip-Seq_Bcells_Human0.90359248
75ETV2_25802403_ChIP-Seq_MESCs_Mouse0.89830494
76PHF8_20622854_ChIP-Seq_HELA_Human0.89630221
77FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87347630
78KDM2B_26808549_Chip-Seq_DND41_Human0.87253952
79TP53_22573176_ChIP-Seq_HFKS_Human0.87006103
80KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.86972643
81VDR_24787735_ChIP-Seq_THP-1_Human0.85745388
82VDR_24763502_ChIP-Seq_THP-1_Human0.84517794
83GATA6_21074721_ChIP-Seq_CACO-2_Human0.84348001
84STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.82800822
85SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.82720694
86SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81615380
87SA1_27219007_Chip-Seq_ERYTHROID_Human0.80743999
88SCL_19346495_ChIP-Seq_HPC-7_Human0.80371440
89ETS1_21867929_ChIP-Seq_TH2_Mouse0.80192233
90BCAT_22108803_ChIP-Seq_LS180_Human0.80175464
91ELF1_20517297_ChIP-Seq_JURKAT_Human0.78542578
92MYC_22102868_ChIP-Seq_BL_Human0.77569278
93MYC_18940864_ChIP-ChIP_HL60_Human0.77044804
94RARB_24833708_ChIP-Seq_LIVER_Mouse0.76843739
95MYC_19829295_ChIP-Seq_ESCs_Human0.76337067
96CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.76334703
97LXR_22292898_ChIP-Seq_THP-1_Human0.74867472
98SPI1_23127762_ChIP-Seq_K562_Human0.74771199
99CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.74055399
100P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.73871751

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to5.86255486
2MP0003045_fibrosis4.37397603
3MP0003763_abnormal_thymus_physiology3.75561488
4MP0003300_gastrointestinal_ulcer3.29387561
5MP0001790_abnormal_immune_system3.25226838
6MP0005387_immune_system_phenotype3.25226838
7MP0009785_altered_susceptibility_to3.20965517
8MP0001800_abnormal_humoral_immune2.82306234
9MP0002166_altered_tumor_susceptibility2.80944605
10MP0006082_CNS_inflammation2.72731759
11MP0003436_decreased_susceptibility_to2.57872338
12MP0001873_stomach_inflammation2.54010382
13MP0001835_abnormal_antigen_presentation2.45430024
14MP0005025_abnormal_response_to2.40772943
15MP0002723_abnormal_immune_serum2.39455885
16MP0005000_abnormal_immune_tolerance2.37529334
17MP0009333_abnormal_splenocyte_physiolog2.35983706
18MP0002452_abnormal_antigen_presenting2.35572914
19MP0002405_respiratory_system_inflammati2.34541969
20MP0002420_abnormal_adaptive_immunity2.31729003
21MP0001819_abnormal_immune_cell2.24555299
22MP0002653_abnormal_ependyma_morphology2.11846786
23MP0002396_abnormal_hematopoietic_system2.11083526
24MP0010155_abnormal_intestine_physiology2.06584527
25MP0002419_abnormal_innate_immunity1.96141146
26MP0002009_preneoplasia1.96054510
27MP0003866_abnormal_defecation1.95229560
28MP0002006_tumorigenesis1.93541449
29MP0002277_abnormal_respiratory_mucosa1.82782051
30MP0001845_abnormal_inflammatory_respons1.81025485
31MP0001851_eye_inflammation1.80505539
32MP0000685_abnormal_immune_system1.80456011
33MP0002398_abnormal_bone_marrow1.70779900
34MP0005408_hypopigmentation1.69444990
35MP0000716_abnormal_immune_system1.68853076
36MP0002148_abnormal_hypersensitivity_rea1.67827111
37MP0004142_abnormal_muscle_tone1.64167939
38MP0003448_altered_tumor_morphology1.60231998
39MP0005083_abnormal_biliary_tract1.59973566
40MP0000703_abnormal_thymus_morphology1.59607938
41MP0003806_abnormal_nucleotide_metabolis1.50998739
42MP0000689_abnormal_spleen_morphology1.43860346
43MP0003646_muscle_fatigue1.42913537
44MP0003693_abnormal_embryo_hatching1.41449337
45MP0005310_abnormal_salivary_gland1.39817818
46MP0003890_abnormal_embryonic-extraembry1.38572392
47MP0002168_other_aberrant_phenotype1.36441050
48MP0002429_abnormal_blood_cell1.36055589
49MP0008469_abnormal_protein_level1.32868960
50MP0002722_abnormal_immune_system1.32797773
51MP0003724_increased_susceptibility_to1.25612561
52MP0002163_abnormal_gland_morphology1.21680785
53MP0000470_abnormal_stomach_morphology1.21345805
54MP0004947_skin_inflammation1.16323447
55MP0004381_abnormal_hair_follicle1.15187607
56MP0008875_abnormal_xenobiotic_pharmacok1.14336572
57MP0000678_abnormal_parathyroid_gland1.12918881
58MP0005166_decreased_susceptibility_to1.09979075
59MP0008569_lethality_at_weaning1.06407589
60MP0001348_abnormal_lacrimal_gland1.05000891
61MP0003252_abnormal_bile_duct1.04161144
62MP0005451_abnormal_body_composition1.03180605
63MP0008007_abnormal_cellular_replicative1.02231659
64MP0004185_abnormal_adipocyte_glucose0.94356733
65MP0003786_premature_aging0.94034758
66MP0001533_abnormal_skeleton_physiology0.92733539
67MP0008872_abnormal_physiological_respon0.91604430
68MP0000569_abnormal_digit_pigmentation0.90662642
69MP0003638_abnormal_response/metabolism_0.86866850
70MP0003950_abnormal_plasma_membrane0.86490209
71MP0008004_abnormal_stomach_pH0.86115508
72MP0002933_joint_inflammation0.85251466
73MP0002928_abnormal_bile_duct0.84044414
74MP0001501_abnormal_sleep_pattern0.83402369
75MP0005645_abnormal_hypothalamus_physiol0.78692300
76MP0005076_abnormal_cell_differentiation0.77221133
77MP0001919_abnormal_reproductive_system0.73080609
78MP0005379_endocrine/exocrine_gland_phen0.71301101
79MP0003191_abnormal_cellular_cholesterol0.71131230
80MP0005464_abnormal_platelet_physiology0.68811239
81MP0001958_emphysema0.68681300
82MP0009764_decreased_sensitivity_to0.67966854
83MP0001853_heart_inflammation0.66523406
84MP0005084_abnormal_gallbladder_morpholo0.65557217
85MP0005075_abnormal_melanosome_morpholog0.65124106
86MP0009643_abnormal_urine_homeostasis0.63837181
87MP0004043_abnormal_pH_regulation0.63772064
88MP0005167_abnormal_blood-brain_barrier0.61397484
89MP0001765_abnormal_ion_homeostasis0.61288959
90MP0009763_increased_sensitivity_to0.59271616
91MP0008873_increased_physiological_sensi0.57728388
92MP0008058_abnormal_DNA_repair0.56407380
93MP0000920_abnormal_myelination0.56250491
94MP0003075_altered_response_to0.55476750
95MP0002136_abnormal_kidney_physiology0.54478094
96MP0002019_abnormal_tumor_incidence0.54208915
97MP0003303_peritoneal_inflammation0.51245137
98MP0003195_calcinosis0.48406788
99MP0002693_abnormal_pancreas_physiology0.48303183
100MP0002736_abnormal_nociception_after0.48223886

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of DNA repair (HP:0003254)6.53048170
2Type I transferrin isoform profile (HP:0003642)5.75945890
3Hypoproteinemia (HP:0003075)5.31571040
4Stomatitis (HP:0010280)5.30166577
5T lymphocytopenia (HP:0005403)4.83654336
6Abnormality of T cell number (HP:0011839)4.65198910
7Nonimmune hydrops fetalis (HP:0001790)4.60898289
8Reduced antithrombin III activity (HP:0001976)4.55183053
9Abnormality of the pons (HP:0007361)4.20223082
10Abnormal protein N-linked glycosylation (HP:0012347)4.07111779
11Abnormal protein glycosylation (HP:0012346)4.07111779
12Abnormal glycosylation (HP:0012345)4.07111779
13Abnormal isoelectric focusing of serum transferrin (HP:0003160)4.07111779
14Hypoplasia of the pons (HP:0012110)3.94676484
15Abnormality of T cells (HP:0002843)3.79599999
16Myopathic facies (HP:0002058)3.67662057
17IgM deficiency (HP:0002850)3.67198984
18Hypochromic microcytic anemia (HP:0004840)3.58941786
19Gastrointestinal infarctions (HP:0005244)3.42927582
20Abnormality of T cell physiology (HP:0011840)3.39384966
21Abnormal delayed hypersensitivity skin test (HP:0002963)3.37560340
22Elevated erythrocyte sedimentation rate (HP:0003565)3.22146886
23Oligomenorrhea (HP:0000876)3.15847648
24Entropion (HP:0000621)3.13507318
25Duplicated collecting system (HP:0000081)3.09786253
26Severe combined immunodeficiency (HP:0004430)3.05780599
27Hypochromic anemia (HP:0001931)2.96807336
28Autoimmune hemolytic anemia (HP:0001890)2.96067077
29Chronic diarrhea (HP:0002028)2.93264011
30Thin bony cortex (HP:0002753)2.88453963
31Poikiloderma (HP:0001029)2.87243306
32Abnormality of the renal collecting system (HP:0004742)2.86606929
33IgG deficiency (HP:0004315)2.82839779
34Acute hepatic failure (HP:0006554)2.76512417
35Abnormality of macrophages (HP:0004311)2.75916316
36Fatigue (HP:0012378)2.72503114
37Prolonged QT interval (HP:0001657)2.60561221
38Clubbing of toes (HP:0100760)2.55223026
39Increased IgM level (HP:0003496)2.51341977
40Generalized aminoaciduria (HP:0002909)2.50035868
413-Methylglutaconic aciduria (HP:0003535)2.43106797
42Decreased subcutaneous fat (HP:0001002)2.41056012
43Peritonitis (HP:0002586)2.40403122
44Hyponatremia (HP:0002902)2.39545902
45Abnormality of eosinophils (HP:0001879)2.37675764
46Enlarged epiphyses (HP:0010580)2.36186211
47Combined immunodeficiency (HP:0005387)2.33656536
48Hepatocellular necrosis (HP:0001404)2.30466683
49Aplasia/Hypoplasia of the uvula (HP:0010293)2.29253620
50Toxemia of pregnancy (HP:0100603)2.26871661
51Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.24836707
52Encephalitis (HP:0002383)2.24145367
53Amelogenesis imperfecta (HP:0000705)2.21948792
54Methylmalonic acidemia (HP:0002912)2.21633319
55Recurrent viral infections (HP:0004429)2.20777650
56Recurrent fungal infections (HP:0002841)2.18944040
57Poor head control (HP:0002421)2.17564344
58Chest pain (HP:0100749)2.17555869
59Pustule (HP:0200039)2.16048612
60Thyroiditis (HP:0100646)2.15944913
61Azoospermia (HP:0000027)2.15406508
62Abnormality of the preputium (HP:0100587)2.15326843
63Decreased activity of mitochondrial respiratory chain (HP:0008972)2.12577757
64Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.12577757
65Eosinophilia (HP:0001880)2.09476080
66Absent thumb (HP:0009777)2.08853101
67Abnormality of the costochondral junction (HP:0000919)2.08289701
68Optic neuritis (HP:0100653)2.05008114
69Retrobulbar optic neuritis (HP:0100654)2.05008114
70Granulocytopenia (HP:0001913)2.04456983
71Keratoconjunctivitis sicca (HP:0001097)2.02448741
72Aplastic anemia (HP:0001915)2.02200866
73Eczematoid dermatitis (HP:0000976)2.01863482
74Abnormality of the ileum (HP:0001549)2.01034552
75Vasculitis (HP:0002633)1.99535129
76Meningitis (HP:0001287)1.97871741
77Leukocytosis (HP:0001974)1.96792425
78Malignant hyperthermia (HP:0002047)1.96071438
79Autoimmune thrombocytopenia (HP:0001973)1.95990109
80Meckel diverticulum (HP:0002245)1.95704028
81Keratitis (HP:0000491)1.95154181
82Milia (HP:0001056)1.94999280
83Delayed epiphyseal ossification (HP:0002663)1.93686598
84Myositis (HP:0100614)1.93274967
85Lymphopenia (HP:0001888)1.92565958
86Abnormality of cells of the lymphoid lineage (HP:0012140)1.89482470
87Deep venous thrombosis (HP:0002625)1.88756992
88Absent rod-and cone-mediated responses on ERG (HP:0007688)1.88709736
89Polycythemia (HP:0001901)1.87955893
90Esophageal atresia (HP:0002032)1.87591462
91Arthropathy (HP:0003040)1.86346365
92Concave nail (HP:0001598)1.85460822
93Exotropia (HP:0000577)1.85378058
94Orchitis (HP:0100796)1.85264667
95Urticaria (HP:0001025)1.84980528
96Methylmalonic aciduria (HP:0012120)1.84901472
97Keratoconjunctivitis (HP:0001096)1.83014238
98Episodic fever (HP:0001954)1.81455920
99Recurrent abscess formation (HP:0002722)1.80961612
100Mediastinal lymphadenopathy (HP:0100721)1.80720929

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK36.75856130
2MAP4K15.54705798
3KDR3.54218601
4ZAP703.50023927
5IKBKE3.43103895
6MAP3K133.22177828
7TXK2.92982109
8MAP3K112.56812964
9MAPK152.41824049
10RIPK42.36616617
11TESK22.25480905
12SCYL22.25278423
13CAMKK22.17780016
14MAP3K142.15320008
15FES2.08047763
16BLK1.99542838
17NEK91.96557401
18MAP3K121.76404448
19JAK31.73170583
20CSK1.69773700
21MARK31.68139866
22IKBKB1.65598714
23ITK1.63256398
24TNK21.60994992
25SYK1.47366783
26BTK1.39256967
27CAMKK11.28820244
28LCK1.28192587
29TBK11.23875890
30ZAK1.14558664
31WNK41.12799935
32PIM11.09035621
33CAMK1D1.05536025
34TIE11.03534865
35TYK21.03480126
36LYN1.00573542
37EPHB10.95806811
38TEC0.83953247
39MAP3K50.82067155
40NME10.81518947
41ADRBK20.79108350
42PRKCI0.78075654
43CLK10.77656028
44PRKCQ0.77439754
45GRK10.74402196
46PASK0.73813461
47CDK120.70835908
48PRKCH0.70625125
49GRK50.67901031
50CSF1R0.66544523
51BMPR20.66416543
52TESK10.63267054
53GRK60.59917526
54HIPK20.55066852
55MAPK100.51777496
56FGR0.51033688
57BCKDK0.50850000
58HCK0.50497787
59PDK10.49976618
60OXSR10.49759830
61STK380.48751384
62KSR10.44940043
63PKN20.40635175
64JAK10.39876709
65MAP3K10.38270067
66TRIB30.38118421
67STK100.37369709
68PTK2B0.37262841
69CAMK1G0.36588331
70STK110.35958696
71FRK0.34479999
72RPS6KA50.33439749
73EIF2AK30.32954964
74LRRK20.32421246
75MAP2K30.31875794
76SMG10.30730536
77MAP2K20.30438119
78WNK10.30254671
79CSNK1A10.29416360
80RIPK10.29212036
81TYRO30.29098508
82RPS6KA60.28278874
83TAOK20.28270714
84PTK60.27978709
85IRAK40.27146320
86YES10.26678829
87RPS6KC10.25890461
88RPS6KL10.25890461
89NEK10.25579322
90CHUK0.23361654
91PRPF4B0.22791502
92CAMK40.22453006
93CDK40.21896185
94MAPK30.21838122
95MAP3K70.21630655
96JAK20.21528916
97UHMK10.20447050
98TSSK60.19642047
99NLK0.19522908
100INSR0.18881357

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.48731611
2T cell receptor signaling pathway_Homo sapiens_hsa046603.47494636
3Allograft rejection_Homo sapiens_hsa053303.02618462
4Autoimmune thyroid disease_Homo sapiens_hsa053202.98752315
5Hematopoietic cell lineage_Homo sapiens_hsa046402.62801572
6Graft-versus-host disease_Homo sapiens_hsa053322.62576696
7NOD-like receptor signaling pathway_Homo sapiens_hsa046212.54094654
8Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.52534220
9Cyanoamino acid metabolism_Homo sapiens_hsa004602.45564601
10Antigen processing and presentation_Homo sapiens_hsa046122.39521322
11N-Glycan biosynthesis_Homo sapiens_hsa005102.38881557
12Measles_Homo sapiens_hsa051622.24833162
13RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.09223727
14Type I diabetes mellitus_Homo sapiens_hsa049401.98323842
15Osteoclast differentiation_Homo sapiens_hsa043801.81026348
16Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.80827266
17Phototransduction_Homo sapiens_hsa047441.79739074
18Intestinal immune network for IgA production_Homo sapiens_hsa046721.71319274
19Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.68989314
20NF-kappa B signaling pathway_Homo sapiens_hsa040641.67603189
21B cell receptor signaling pathway_Homo sapiens_hsa046621.64021366
22Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.63489790
23Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.63457881
24Jak-STAT signaling pathway_Homo sapiens_hsa046301.53725942
25Histidine metabolism_Homo sapiens_hsa003401.48601097
26Herpes simplex infection_Homo sapiens_hsa051681.47723533
27Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.40719593
28Viral myocarditis_Homo sapiens_hsa054161.38513404
29Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.35314477
30Proteasome_Homo sapiens_hsa030501.26521908
31Mineral absorption_Homo sapiens_hsa049781.22677051
32Fatty acid biosynthesis_Homo sapiens_hsa000611.20965174
33Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.20286433
34Toll-like receptor signaling pathway_Homo sapiens_hsa046201.15272491
35Vitamin digestion and absorption_Homo sapiens_hsa049771.14801670
36alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.14616351
37Chemokine signaling pathway_Homo sapiens_hsa040621.12984471
38Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.08436730
39Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.08169934
40Asthma_Homo sapiens_hsa053101.06696559
41ABC transporters_Homo sapiens_hsa020101.06493034
42Leishmaniasis_Homo sapiens_hsa051401.06218211
43Linoleic acid metabolism_Homo sapiens_hsa005911.05156510
44Fanconi anemia pathway_Homo sapiens_hsa034600.99786604
45Influenza A_Homo sapiens_hsa051640.89449419
46Hepatitis B_Homo sapiens_hsa051610.87205141
47Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.85353085
48Apoptosis_Homo sapiens_hsa042100.84687728
49TNF signaling pathway_Homo sapiens_hsa046680.84278282
50Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.83283167
51SNARE interactions in vesicular transport_Homo sapiens_hsa041300.83211055
52VEGF signaling pathway_Homo sapiens_hsa043700.81071021
53Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.76029240
54Epstein-Barr virus infection_Homo sapiens_hsa051690.74815162
55Staphylococcus aureus infection_Homo sapiens_hsa051500.72784745
56Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.72727908
57Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.70473408
58Rheumatoid arthritis_Homo sapiens_hsa053230.69330923
59Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.68941926
60Glycerolipid metabolism_Homo sapiens_hsa005610.67712522
61Malaria_Homo sapiens_hsa051440.64928301
62Viral carcinogenesis_Homo sapiens_hsa052030.61946091
63Tuberculosis_Homo sapiens_hsa051520.60943676
64Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.58112022
65HTLV-I infection_Homo sapiens_hsa051660.55288834
66Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.52390377
67African trypanosomiasis_Homo sapiens_hsa051430.49284027
68Nucleotide excision repair_Homo sapiens_hsa034200.49259578
69Pentose and glucuronate interconversions_Homo sapiens_hsa000400.45586084
70Oxidative phosphorylation_Homo sapiens_hsa001900.43441572
71Pertussis_Homo sapiens_hsa051330.42662139
72Bile secretion_Homo sapiens_hsa049760.41301270
73Ether lipid metabolism_Homo sapiens_hsa005650.39869816
74Hepatitis C_Homo sapiens_hsa051600.39817140
75beta-Alanine metabolism_Homo sapiens_hsa004100.35994290
76Toxoplasmosis_Homo sapiens_hsa051450.35668882
77Parkinsons disease_Homo sapiens_hsa050120.34570717
78Other glycan degradation_Homo sapiens_hsa005110.34229508
79Renin secretion_Homo sapiens_hsa049240.33457579
80Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.31809158
81Shigellosis_Homo sapiens_hsa051310.31766130
82Legionellosis_Homo sapiens_hsa051340.30593750
83RNA degradation_Homo sapiens_hsa030180.29544674
84Arachidonic acid metabolism_Homo sapiens_hsa005900.29173416
85RNA transport_Homo sapiens_hsa030130.28806877
86Tryptophan metabolism_Homo sapiens_hsa003800.27954375
87MAPK signaling pathway_Homo sapiens_hsa040100.27903141
88One carbon pool by folate_Homo sapiens_hsa006700.25203585
89Olfactory transduction_Homo sapiens_hsa047400.23998802
90Complement and coagulation cascades_Homo sapiens_hsa046100.21692349
91Nitrogen metabolism_Homo sapiens_hsa009100.20736761
92Endocytosis_Homo sapiens_hsa041440.20537665
93Morphine addiction_Homo sapiens_hsa050320.19618932
94Acute myeloid leukemia_Homo sapiens_hsa052210.19017416
95Regulation of autophagy_Homo sapiens_hsa041400.16437465
96Phagosome_Homo sapiens_hsa041450.16171623
97Vascular smooth muscle contraction_Homo sapiens_hsa042700.15486748
98Platelet activation_Homo sapiens_hsa046110.15347330
99Drug metabolism - other enzymes_Homo sapiens_hsa009830.15101114
100Alzheimers disease_Homo sapiens_hsa050100.14823919

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