TRBV7-8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cell killing (GO:0031342)7.22591052
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)7.22591052
3response to interleukin-15 (GO:0070672)7.04239625
4cellular response to interleukin-15 (GO:0071350)6.57199436
5antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.33276433
6tolerance induction (GO:0002507)6.19684533
7regulation of isotype switching to IgG isotypes (GO:0048302)6.15259641
8positive regulation of gamma-delta T cell activation (GO:0046645)6.14930751
9negative T cell selection (GO:0043383)6.08693122
10negative thymic T cell selection (GO:0045060)6.04100151
11positive regulation of natural killer cell differentiation (GO:0032825)5.79640576
12regulation of B cell receptor signaling pathway (GO:0050855)5.72350082
13positive regulation of interleukin-2 biosynthetic process (GO:0045086)5.65343717
14antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.57791834
15negative regulation of T cell mediated immunity (GO:0002710)5.25220467
16regulation of regulatory T cell differentiation (GO:0045589)5.22540142
17positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.21936979
18antigen processing and presentation of endogenous antigen (GO:0019883)5.06017416
19antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.00772485
20regulation of T cell tolerance induction (GO:0002664)4.90354994
21regulation of gamma-delta T cell differentiation (GO:0045586)4.80815536
22regulation of interleukin-2 biosynthetic process (GO:0045076)4.79808319
23thymic T cell selection (GO:0045061)4.71224658
24positive regulation of interleukin-17 production (GO:0032740)4.68463305
25negative regulation of lymphocyte mediated immunity (GO:0002707)4.66729162
26leukocyte aggregation (GO:0070486)4.64595557
27regulation of natural killer cell mediated cytotoxicity (GO:0042269)4.64444432
28regulation of natural killer cell mediated immunity (GO:0002715)4.64444432
29T cell selection (GO:0045058)4.55051810
30regulation of gamma-delta T cell activation (GO:0046643)4.51219333
31positive T cell selection (GO:0043368)4.41378604
32positive regulation of natural killer cell mediated immunity (GO:0002717)4.36760640
33positive thymic T cell selection (GO:0045059)4.26002542
34negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)4.24781541
35negative regulation of T-helper cell differentiation (GO:0045623)4.20991896
36negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)4.20991896
37positive regulation of B cell differentiation (GO:0045579)4.20298886
38regulation of tolerance induction (GO:0002643)4.18724356
39positive regulation of tolerance induction (GO:0002645)4.18251320
40regulation of natural killer cell differentiation (GO:0032823)4.08879053
41activated T cell proliferation (GO:0050798)4.07458549
42regulation of alpha-beta T cell proliferation (GO:0046640)4.01698580
43negative regulation of adaptive immune response based on somatic recombination of immune receptors b4.01421062
44negative regulation of leukocyte mediated immunity (GO:0002704)4.00839747
45positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.99454444
46regulation of leukocyte mediated cytotoxicity (GO:0001910)3.97721726
47regulation of T cell mediated cytotoxicity (GO:0001914)3.96652098
48T cell migration (GO:0072678)3.94904129
49positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.93326663
50interferon-gamma production (GO:0032609)3.92732559
51T cell receptor signaling pathway (GO:0050852)3.91795852
52positive regulation of T cell differentiation in thymus (GO:0033089)3.91679982
53negative regulation of adaptive immune response (GO:0002820)3.91593649
54T cell homeostasis (GO:0043029)3.88252704
55regulation of B cell differentiation (GO:0045577)3.85399344
56positive regulation of isotype switching (GO:0045830)3.83136489
57antigen receptor-mediated signaling pathway (GO:0050851)3.80183882
58positive regulation of alpha-beta T cell proliferation (GO:0046641)3.78362874
59regulation of cell killing (GO:0031341)3.77711624
60regulation of isotype switching (GO:0045191)3.76527583
61type I interferon signaling pathway (GO:0060337)3.73469765
62cellular response to type I interferon (GO:0071357)3.73469765
63response to type I interferon (GO:0034340)3.69743021
64alpha-beta T cell differentiation (GO:0046632)3.66088762
65positive regulation of T cell mediated cytotoxicity (GO:0001916)3.61178987
66regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.58475469
67positive regulation of cell killing (GO:0031343)3.55021563
68CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.54145803
69positive regulation of interleukin-2 production (GO:0032743)3.54084160
70antigen processing and presentation via MHC class Ib (GO:0002475)3.47630768
71positive regulation of granulocyte differentiation (GO:0030854)3.46656039
72negative regulation of immunoglobulin mediated immune response (GO:0002890)3.45253777
73negative regulation of B cell mediated immunity (GO:0002713)3.45253777
74positive regulation of DNA recombination (GO:0045911)3.42951721
75alpha-beta T cell activation (GO:0046631)3.35567481
76negative regulation of interleukin-12 production (GO:0032695)3.35181078
77CD4-positive, alpha-beta T cell differentiation (GO:0043367)3.30143466
78regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)3.28852622
79lymphocyte costimulation (GO:0031294)3.28292942
80positive regulation of lymphocyte mediated immunity (GO:0002708)3.27905230
81regulation of chronic inflammatory response (GO:0002676)3.26557806
82regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.19290528
83T cell costimulation (GO:0031295)3.18322343
84positive regulation of interleukin-10 production (GO:0032733)3.15867660
85positive regulation of interleukin-4 production (GO:0032753)3.13932868
86regulation of alpha-beta T cell activation (GO:0046634)3.13679373
87mast cell activation (GO:0045576)3.13548255
88regulation of T cell mediated immunity (GO:0002709)3.11567185
89regulation of interleukin-17 production (GO:0032660)3.11255912
90defense response to protozoan (GO:0042832)3.11225912
91mucosal-associated lymphoid tissue development (GO:0048537)3.11051129
92Peyers patch development (GO:0048541)3.11051129
93detection of bacterium (GO:0016045)3.10315326
94B cell receptor signaling pathway (GO:0050853)3.07583026
95T cell differentiation (GO:0030217)3.07568671
96NIK/NF-kappaB signaling (GO:0038061)3.07517461
97regulation of lymphocyte mediated immunity (GO:0002706)3.07100774
98positive regulation of lymphocyte differentiation (GO:0045621)3.05750480
99positive regulation of T cell mediated immunity (GO:0002711)3.04528509
100regulation of immunoglobulin production (GO:0002637)3.03270671

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse7.21264626
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human6.68300158
3IRF8_22096565_ChIP-ChIP_GC-B_Human5.96659106
4RUNX_20019798_ChIP-Seq_JUKART_Human4.06194884
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.66853089
6IRF8_21731497_ChIP-ChIP_J774_Mouse3.45157456
7STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.44448625
8MYB_26560356_Chip-Seq_TH2_Human3.36412901
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.35955664
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.32649663
11BP1_19119308_ChIP-ChIP_Hs578T_Human3.27328478
12STAT4_19710469_ChIP-ChIP_TH1__Mouse3.02960287
13MYB_26560356_Chip-Seq_TH1_Human2.87529417
14MAF_26560356_Chip-Seq_TH1_Human2.82817727
15SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.73626436
16FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.68134030
17SMAD_19615063_ChIP-ChIP_OVARY_Human2.47790021
18SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.40472920
19GATA3_27048872_Chip-Seq_THYMUS_Human2.36374044
20UTX_26944678_Chip-Seq_JUKART_Human2.36049645
21IRF8_27001747_Chip-Seq_BMDM_Mouse2.34174360
22SCL_19346495_ChIP-Seq_HPC-7_Human2.29645077
23NOTCH1_21737748_ChIP-Seq_TLL_Human2.28735557
24BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.26119936
25SPI1_23547873_ChIP-Seq_NB4_Human2.24931337
26MAF_26560356_Chip-Seq_TH2_Human2.20872942
27MYC_22102868_ChIP-Seq_BL_Human2.20023837
28ELF1_17652178_ChIP-ChIP_JURKAT_Human2.19877241
29RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.13306340
30NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.09731230
31E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.05784047
32GATA3_26560356_Chip-Seq_TH2_Human1.94957625
33MYB_21317192_ChIP-Seq_ERMYB_Mouse1.93705618
34SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.85286530
35RUNX1_22412390_ChIP-Seq_EML_Mouse1.79625016
36VDR_21846776_ChIP-Seq_THP-1_Human1.78721516
37VDR_24763502_ChIP-Seq_THP-1_Human1.74811826
38SPI1_23127762_ChIP-Seq_K562_Human1.72085243
39KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.71392119
40VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.69622282
41FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.63321121
42MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.61088195
43TCF7_22412390_ChIP-Seq_EML_Mouse1.54030565
44SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.54003203
45RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.49447934
46BRD4_27068464_Chip-Seq_AML-cells_Mouse1.48989682
47RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.45701249
48KDM2B_26808549_Chip-Seq_DND41_Human1.39297084
49KDM2B_26808549_Chip-Seq_SUP-B15_Human1.35409082
50CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.35383230
51LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.35325479
52KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.33706003
53GATA1_22025678_ChIP-Seq_K562_Human1.33618200
54CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.31544966
55NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.28748316
56LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.25364711
57VDR_24787735_ChIP-Seq_THP-1_Human1.25051051
58ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.24440649
59PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.23669543
60CIITA_25753668_ChIP-Seq_RAJI_Human1.21943352
61PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.18509860
62GATA2_22383799_ChIP-Seq_G1ME_Mouse1.15136202
63CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14340828
64CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08990532
65TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.08941120
66Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.08856466
67KDM2B_26808549_Chip-Seq_JURKAT_Human1.08575477
68NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.08246568
69TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.08164154
70SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.06707584
71GATA1_19941827_ChIP-Seq_MEL_Mouse1.05583398
72FOXP3_21729870_ChIP-Seq_TREG_Human1.00899352
73CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99880659
74PU_27001747_Chip-Seq_BMDM_Mouse0.99501398
75SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98915430
76PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98904416
77CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.97598259
78GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.96818348
79E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.96157153
80GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94769439
81GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93237513
82PU.1_20513432_ChIP-Seq_Bcells_Mouse0.92567955
83PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92360080
84GATA1_22383799_ChIP-Seq_G1ME_Mouse0.91246393
85VDR_23849224_ChIP-Seq_CD4+_Human0.88563868
86STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.81614481
87SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79981591
88EGR1_19032775_ChIP-ChIP_M12_Human0.78708571
89FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78431266
90FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.77643600
91GATA3_26560356_Chip-Seq_TH1_Human0.76928255
92BCL6_27268052_Chip-Seq_Bcells_Human0.76082234
93RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.75323322
94RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.74797013
95ELK3_25401928_ChIP-Seq_HUVEC_Human0.73975145
96NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.73433521
97HOXB4_20404135_ChIP-ChIP_EML_Mouse0.70773817
98GATA1_19941826_ChIP-Seq_K562_Human0.69282090
99NCOR1_26117541_ChIP-Seq_K562_Human0.68872825
100TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.68649521

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology4.77656746
2MP0005671_abnormal_response_to4.30003880
3MP0001873_stomach_inflammation3.92628223
4MP0001835_abnormal_antigen_presentation3.66752071
5MP0001800_abnormal_humoral_immune3.45088772
6MP0003436_decreased_susceptibility_to3.34749278
7MP0005387_immune_system_phenotype3.27632499
8MP0001790_abnormal_immune_system3.27632499
9MP0005000_abnormal_immune_tolerance3.24560446
10MP0009333_abnormal_splenocyte_physiolog3.06764725
11MP0003724_increased_susceptibility_to3.03385727
12MP0002723_abnormal_immune_serum2.85604334
13MP0002420_abnormal_adaptive_immunity2.79153117
14MP0001819_abnormal_immune_cell2.72400301
15MP0005025_abnormal_response_to2.72205627
16MP0002452_abnormal_antigen_presenting2.66708949
17MP0009785_altered_susceptibility_to2.66112060
18MP0000685_abnormal_immune_system2.64668108
19MP0006082_CNS_inflammation2.53153113
20MP0002405_respiratory_system_inflammati2.51322308
21MP0003866_abnormal_defecation2.48105994
22MP0002398_abnormal_bone_marrow2.44826750
23MP0000703_abnormal_thymus_morphology2.36632561
24MP0002419_abnormal_innate_immunity2.34854009
25MP0010155_abnormal_intestine_physiology2.26230452
26MP0002148_abnormal_hypersensitivity_rea2.25601975
27MP0000716_abnormal_immune_system2.25512346
28MP0000465_gastrointestinal_hemorrhage2.08064294
29MP0000689_abnormal_spleen_morphology2.07533466
30MP0001348_abnormal_lacrimal_gland2.01628198
31MP0004381_abnormal_hair_follicle1.98842797
32MP0002722_abnormal_immune_system1.95769889
33MP0003300_gastrointestinal_ulcer1.95139815
34MP0003303_peritoneal_inflammation1.91852452
35MP0005464_abnormal_platelet_physiology1.84911282
36MP0005310_abnormal_salivary_gland1.83958805
37MP0001845_abnormal_inflammatory_respons1.83567994
38MP0002396_abnormal_hematopoietic_system1.83146240
39MP0002429_abnormal_blood_cell1.75979012
40MP0004947_skin_inflammation1.75857122
41MP0005075_abnormal_melanosome_morpholog1.62125049
42MP0002277_abnormal_respiratory_mucosa1.61028654
43MP0002166_altered_tumor_susceptibility1.58795952
44MP0001533_abnormal_skeleton_physiology1.51418402
45MP0001851_eye_inflammation1.49890105
46MP0008469_abnormal_protein_level1.34337565
47MP0002132_abnormal_respiratory_system1.26804346
48MP0003045_fibrosis1.15947947
49MP0002138_abnormal_hepatobiliary_system1.13578323
50MP0002933_joint_inflammation1.11645364
51MP0001663_abnormal_digestive_system1.10305113
52MP0009764_decreased_sensitivity_to1.09076883
53MP0002009_preneoplasia1.00589868
54MP0002006_tumorigenesis0.99683498
55MP0001853_heart_inflammation0.99644260
56MP0000858_altered_metastatic_potential0.97063205
57MP0003172_abnormal_lysosome_physiology0.93325061
58MP0000490_abnormal_crypts_of0.91747226
59MP0002693_abnormal_pancreas_physiology0.90441652
60MP0002998_abnormal_bone_remodeling0.85271197
61MP0000015_abnormal_ear_pigmentation0.84456371
62MP0000569_abnormal_digit_pigmentation0.83912817
63MP0009278_abnormal_bone_marrow0.79587931
64MP0003828_pulmonary_edema0.79412127
65MP0005166_decreased_susceptibility_to0.78706716
66MP0004742_abnormal_vestibular_system0.75689786
67MP0004808_abnormal_hematopoietic_stem0.74162499
68MP0001986_abnormal_taste_sensitivity0.73595660
69MP0002163_abnormal_gland_morphology0.72510113
70MP0008260_abnormal_autophagy0.70410149
71MP0009763_increased_sensitivity_to0.68845253
72MP0005451_abnormal_body_composition0.64564453
73MP0003191_abnormal_cellular_cholesterol0.63740785
74MP0005381_digestive/alimentary_phenotyp0.62789172
75MP0002019_abnormal_tumor_incidence0.62640124
76MP0004883_abnormal_blood_vessel0.59491095
77MP0003183_abnormal_peptide_metabolism0.58605663
78MP0003221_abnormal_cardiomyocyte_apopto0.56606897
79MP0001545_abnormal_hematopoietic_system0.56308738
80MP0005397_hematopoietic_system_phenotyp0.56308738
81MP0003448_altered_tumor_morphology0.56010729
82MP0005390_skeleton_phenotype0.55705432
83MP0001919_abnormal_reproductive_system0.55150649
84MP0004510_myositis0.54425614
85MP0000249_abnormal_blood_vessel0.51223498
86MP0008961_abnormal_basal_metabolism0.51195592
87MP0003795_abnormal_bone_structure0.51185704
88MP0002332_abnormal_exercise_endurance0.48483643
89MP0009840_abnormal_foam_cell0.47553177
90MP0009765_abnormal_xenobiotic_induced0.46946833
91MP0003075_altered_response_to0.40318099
92MP0004130_abnormal_muscle_cell0.40152932
93MP0002971_abnormal_brown_adipose0.39456008
94MP0002928_abnormal_bile_duct0.39412840
95MP0003646_muscle_fatigue0.39375643
96MP0002136_abnormal_kidney_physiology0.39345927
97MP0008569_lethality_at_weaning0.38243075
98MP0000609_abnormal_liver_physiology0.37956128
99MP0008004_abnormal_stomach_pH0.35676228
100MP0000477_abnormal_intestine_morphology0.35301638

Predicted human phenotypes

RankGene SetZ-score
1Autoimmune hemolytic anemia (HP:0001890)6.77903286
2Stomatitis (HP:0010280)6.49645834
3Elevated erythrocyte sedimentation rate (HP:0003565)6.26807778
4T lymphocytopenia (HP:0005403)5.82075866
5Abnormality of T cell number (HP:0011839)5.48047986
6Chronic diarrhea (HP:0002028)5.41550941
7Eczematoid dermatitis (HP:0000976)5.06236830
8Gastrointestinal infarctions (HP:0005244)4.87935276
9Myositis (HP:0100614)4.71512855
10Abnormal delayed hypersensitivity skin test (HP:0002963)4.46207817
11Abnormality of T cells (HP:0002843)4.43250882
12Severe combined immunodeficiency (HP:0004430)4.25231584
13Recurrent fungal infections (HP:0002841)4.07699809
14Recurrent abscess formation (HP:0002722)4.05279465
15Mediastinal lymphadenopathy (HP:0100721)4.04055434
16Inflammation of the large intestine (HP:0002037)4.03822528
17Recurrent bacterial skin infections (HP:0005406)3.99746769
18Gastrointestinal inflammation (HP:0004386)3.97970032
19Orchitis (HP:0100796)3.96264911
20Meningitis (HP:0001287)3.90222291
21Chronic obstructive pulmonary disease (HP:0006510)3.88008754
22Obstructive lung disease (HP:0006536)3.88008754
23Panhypogammaglobulinemia (HP:0003139)3.87411938
24Retrobulbar optic neuritis (HP:0100654)3.82735855
25Optic neuritis (HP:0100653)3.82735855
26Pulmonary infiltrates (HP:0002113)3.81891497
27IgG deficiency (HP:0004315)3.68319254
28Vasculitis (HP:0002633)3.66496612
29Chest pain (HP:0100749)3.64280511
30Abnormality of macrophages (HP:0004311)3.53050448
31Papilledema (HP:0001085)3.39886836
32Recurrent cutaneous fungal infections (HP:0011370)3.39580616
33Chronic mucocutaneous candidiasis (HP:0002728)3.39580616
34Abnormality of T cell physiology (HP:0011840)3.30752384
35Leukocytosis (HP:0001974)3.29757509
36Combined immunodeficiency (HP:0005387)3.29577551
37Abnormality of eosinophils (HP:0001879)3.29363755
38Pustule (HP:0200039)3.29282217
39Increased IgM level (HP:0003496)3.28022928
40Encephalitis (HP:0002383)3.26584123
41Hemoptysis (HP:0002105)3.19027885
42Recurrent skin infections (HP:0001581)3.00454704
43Recurrent viral infections (HP:0004429)2.99298757
44Spontaneous hematomas (HP:0007420)2.98053524
45Granulocytopenia (HP:0001913)2.96326162
46Prolonged bleeding time (HP:0003010)2.93774958
47Keratoconjunctivitis sicca (HP:0001097)2.93536994
48Joint swelling (HP:0001386)2.91533477
49Hypochromic microcytic anemia (HP:0004840)2.89535134
50Abnormality of the prostate (HP:0008775)2.87445280
51Epistaxis (HP:0000421)2.85086714
52Pulmonary embolism (HP:0002204)2.83778196
53Eosinophilia (HP:0001880)2.83774480
54Recurrent bronchitis (HP:0002837)2.80900227
55Thyroiditis (HP:0100646)2.79459836
56Hypochromic anemia (HP:0001931)2.75048455
57Keratoconjunctivitis (HP:0001096)2.72140018
58Lymphopenia (HP:0001888)2.70174322
59Arterial thrombosis (HP:0004420)2.68634926
60Abnormality of the fingertips (HP:0001211)2.67782120
61Agammaglobulinemia (HP:0004432)2.61503028
62Abnormality of B cell number (HP:0010975)2.59960436
63Slow saccadic eye movements (HP:0000514)2.59921587
64Abnormality of cells of the lymphoid lineage (HP:0012140)2.58887005
65Gangrene (HP:0100758)2.58295252
66Recurrent gram-negative bacterial infections (HP:0005420)2.57971653
67B lymphocytopenia (HP:0010976)2.56224846
68IgM deficiency (HP:0002850)2.55434989
69Increased IgE level (HP:0003212)2.53832927
70Gingival bleeding (HP:0000225)2.47214700
71Anorexia (HP:0002039)2.44036375
72Abnormality of the pleura (HP:0002103)2.42607920
73Urticaria (HP:0001025)2.36834273
74Gingivitis (HP:0000230)2.36825164
75Amaurosis fugax (HP:0100576)2.34778438
76Hypergammaglobulinemia (HP:0010702)2.30940105
77Verrucae (HP:0200043)2.29053432
78Papilloma (HP:0012740)2.29053432
79Lymphoma (HP:0002665)2.26548529
80Ureteral stenosis (HP:0000071)2.20696575
81Sepsis (HP:0100806)2.18226212
82Glomerulopathy (HP:0100820)2.17236477
83Ureteral obstruction (HP:0006000)2.11260785
84Polyneuropathy (HP:0001271)2.06397273
85Acute hepatic failure (HP:0006554)2.05931883
86Cellulitis (HP:0100658)2.05731624
87Microcytic anemia (HP:0001935)2.05610989
88Petechiae (HP:0000967)2.04477518
89Skin rash (HP:0000988)2.02555285
90Chronic otitis media (HP:0000389)1.95968851
91Restrictive lung disease (HP:0002091)1.95075096
92Pulmonary fibrosis (HP:0002206)1.93097888
93Recurrent sinusitis (HP:0011108)1.92200353
94Skin ulcer (HP:0200042)1.89160576
95Thrombocytosis (HP:0001894)1.88508651
96Episodic fever (HP:0001954)1.88203230
97Colitis (HP:0002583)1.86317979
98Hypoplasia of the thymus (HP:0000778)1.85773860
99Hypoproteinemia (HP:0003075)1.85305363
100Keratitis (HP:0000491)1.83337337

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK6.18240164
2MAP4K14.79307772
3ITK3.18365671
4TYK23.15814256
5RIPK43.00598178
6JAK33.00353108
7FES2.59333400
8ZAP702.34250191
9BTK2.29445685
10JAK12.24591941
11SIK32.10138787
12LCK2.00528917
13CSK1.99853523
14NLK1.95247350
15TEC1.94771094
16HCK1.89999324
17GRK61.80284039
18IKBKE1.78350772
19TNK21.77785321
20PRPF4B1.74893009
21IRAK41.72416465
22FGFR41.59551465
23SYK1.59334803
24TAOK31.58954873
25KSR21.45615467
26PASK1.43556232
27JAK21.41621390
28MAP2K31.40594014
29LYN1.40513651
30ERN11.39587104
31MAP3K131.35865827
32BLK1.35852047
33EPHB11.32270544
34MARK31.31594338
35TAOK11.20204849
36FGFR31.18507696
37MAP3K141.16815768
38EIF2AK11.13625712
39CAMKK21.11171365
40TBK11.09325464
41CAMKK11.01567900
42MAP3K30.96022655
43IKBKB0.92792255
44KSR10.88690287
45RAF10.87271515
46PRKCQ0.86136615
47CLK10.84482700
48SIK20.83976333
49KIT0.82480163
50FYN0.78704285
51TYRO30.78057488
52CSF1R0.77119288
53STK100.74179756
54MAP3K110.73904842
55MAP3K10.70064249
56SGK30.69396921
57PIM10.68982531
58PTK60.66496662
59HIPK20.65550709
60IRAK10.62642349
61MAPK110.61887730
62PDK10.57103419
63CDK40.56714189
64GRK70.53504346
65MAPK120.52858578
66TAOK20.51561796
67IGF1R0.50573228
68SGK20.50393847
69FGR0.47579358
70LRRK20.46672940
71BMPR20.45808360
72PDGFRB0.45142530
73EPHA30.42401560
74KDR0.41781742
75PRKAA20.41539182
76MARK20.41214044
77BRD40.40623142
78FGFR20.38563792
79PAK60.35944638
80MAP2K60.35721369
81PIK3CG0.35623315
82EIF2AK30.35535880
83MAP3K100.35335599
84STK380.34834410
85PRKCH0.34052849
86YES10.32188840
87MAPK70.31429448
88PAK30.31138253
89STK110.29361220
90PRKCZ0.27246571
91STK240.26629722
92PRKD20.25828311
93MAP3K70.25346251
94MELK0.24719860
95RET0.24606254
96SIK10.24271014
97SGK10.24050089
98SGK2230.23357677
99SGK4940.23357677
100CAMK40.20896075

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.30257050
2T cell receptor signaling pathway_Homo sapiens_hsa046603.56987982
3Autoimmune thyroid disease_Homo sapiens_hsa053203.32603734
4Allograft rejection_Homo sapiens_hsa053303.23091228
5Inflammatory bowel disease (IBD)_Homo sapiens_hsa053213.16721644
6Measles_Homo sapiens_hsa051623.03532341
7Graft-versus-host disease_Homo sapiens_hsa053322.78052750
8Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.61710933
9Hematopoietic cell lineage_Homo sapiens_hsa046402.44192299
10Osteoclast differentiation_Homo sapiens_hsa043802.36895726
11Jak-STAT signaling pathway_Homo sapiens_hsa046302.27208697
12Type I diabetes mellitus_Homo sapiens_hsa049402.14176331
13Intestinal immune network for IgA production_Homo sapiens_hsa046722.06280290
14B cell receptor signaling pathway_Homo sapiens_hsa046622.01329248
15NF-kappa B signaling pathway_Homo sapiens_hsa040641.98527693
16Leishmaniasis_Homo sapiens_hsa051401.96052580
17Acute myeloid leukemia_Homo sapiens_hsa052211.80643609
18Viral myocarditis_Homo sapiens_hsa054161.79433795
19Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.70841269
20Antigen processing and presentation_Homo sapiens_hsa046121.63915086
21Chemokine signaling pathway_Homo sapiens_hsa040621.63761658
22Herpes simplex infection_Homo sapiens_hsa051681.60583275
23RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.51714165
24Staphylococcus aureus infection_Homo sapiens_hsa051501.43920225
25Toll-like receptor signaling pathway_Homo sapiens_hsa046201.38526689
26Influenza A_Homo sapiens_hsa051641.37424969
27Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.34777291
28Hepatitis B_Homo sapiens_hsa051611.33658190
29Non-small cell lung cancer_Homo sapiens_hsa052231.31102657
30NOD-like receptor signaling pathway_Homo sapiens_hsa046211.29410342
31TNF signaling pathway_Homo sapiens_hsa046681.27347287
32Tuberculosis_Homo sapiens_hsa051521.27281781
33Asthma_Homo sapiens_hsa053101.26856099
34Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.26523791
35Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.26037762
36Toxoplasmosis_Homo sapiens_hsa051451.19385063
37Hepatitis C_Homo sapiens_hsa051601.11762204
38Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.04589674
39Platelet activation_Homo sapiens_hsa046111.04047463
40HTLV-I infection_Homo sapiens_hsa051661.02837294
41Apoptosis_Homo sapiens_hsa042101.02318262
42Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.01904956
43Malaria_Homo sapiens_hsa051441.00508152
44Viral carcinogenesis_Homo sapiens_hsa052030.99516952
45Pancreatic cancer_Homo sapiens_hsa052120.99024165
46VEGF signaling pathway_Homo sapiens_hsa043700.98704016
47Prolactin signaling pathway_Homo sapiens_hsa049170.98566923
48Legionellosis_Homo sapiens_hsa051340.98148135
49Leukocyte transendothelial migration_Homo sapiens_hsa046700.97681195
50Epstein-Barr virus infection_Homo sapiens_hsa051690.86516649
51Chronic myeloid leukemia_Homo sapiens_hsa052200.83074626
52FoxO signaling pathway_Homo sapiens_hsa040680.80519828
53Phosphatidylinositol signaling system_Homo sapiens_hsa040700.80503588
54Colorectal cancer_Homo sapiens_hsa052100.78871678
55African trypanosomiasis_Homo sapiens_hsa051430.78360694
56Rheumatoid arthritis_Homo sapiens_hsa053230.75476029
57Shigellosis_Homo sapiens_hsa051310.71430481
58Transcriptional misregulation in cancer_Homo sapiens_hsa052020.69119604
59Endometrial cancer_Homo sapiens_hsa052130.66565179
60Dorso-ventral axis formation_Homo sapiens_hsa043200.65468630
61Sphingolipid signaling pathway_Homo sapiens_hsa040710.65239382
62AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.65157617
63Renal cell carcinoma_Homo sapiens_hsa052110.63530113
64Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.63358842
65SNARE interactions in vesicular transport_Homo sapiens_hsa041300.60466006
66Endocytosis_Homo sapiens_hsa041440.59433970
67Insulin resistance_Homo sapiens_hsa049310.59210359
68Neurotrophin signaling pathway_Homo sapiens_hsa047220.56994922
69Inositol phosphate metabolism_Homo sapiens_hsa005620.54190172
70MAPK signaling pathway_Homo sapiens_hsa040100.50253860
71Phagosome_Homo sapiens_hsa041450.49417350
72Pertussis_Homo sapiens_hsa051330.48081476
73Choline metabolism in cancer_Homo sapiens_hsa052310.47565592
74Phospholipase D signaling pathway_Homo sapiens_hsa040720.47367055
75Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.46442678
76Carbohydrate digestion and absorption_Homo sapiens_hsa049730.44574581
77Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.43649128
78Prostate cancer_Homo sapiens_hsa052150.41121828
79Regulation of autophagy_Homo sapiens_hsa041400.39773378
80Notch signaling pathway_Homo sapiens_hsa043300.34522995
81Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.34360804
82Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.33376772
83Long-term potentiation_Homo sapiens_hsa047200.30766827
84Thyroid cancer_Homo sapiens_hsa052160.30320736
85Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.29870502
86Thyroid hormone signaling pathway_Homo sapiens_hsa049190.29485768
87ErbB signaling pathway_Homo sapiens_hsa040120.28626431
88Adipocytokine signaling pathway_Homo sapiens_hsa049200.28304076
89mTOR signaling pathway_Homo sapiens_hsa041500.27912836
90Other glycan degradation_Homo sapiens_hsa005110.26808501
91Glycerophospholipid metabolism_Homo sapiens_hsa005640.26632187
92Ras signaling pathway_Homo sapiens_hsa040140.25806465
93Salmonella infection_Homo sapiens_hsa051320.23830588
94GnRH signaling pathway_Homo sapiens_hsa049120.19668432
95Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.19403563
96Glioma_Homo sapiens_hsa052140.19128556
97Rap1 signaling pathway_Homo sapiens_hsa040150.19016813
98HIF-1 signaling pathway_Homo sapiens_hsa040660.16462769
99Circadian rhythm_Homo sapiens_hsa047100.16359994
100alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.16045025

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