TRBV7-9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative T cell selection (GO:0043383)7.61576872
2negative thymic T cell selection (GO:0045060)6.97637600
3NIK/NF-kappaB signaling (GO:0038061)6.86516438
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.85716193
5antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.21059194
6regulation of isotype switching to IgG isotypes (GO:0048302)5.96467388
7antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.91728614
8positive T cell selection (GO:0043368)5.75659396
9positive thymic T cell selection (GO:0045059)5.44816269
10thymic T cell selection (GO:0045061)5.43898891
11antigen processing and presentation of endogenous antigen (GO:0019883)5.36914393
12negative regulation of cell killing (GO:0031342)5.34133146
13negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.34133146
14cellular response to interleukin-15 (GO:0071350)5.33478371
15leukocyte aggregation (GO:0070486)5.27144867
16activated T cell proliferation (GO:0050798)5.14623766
17regulation of T cell mediated cytotoxicity (GO:0001914)4.92902186
18T cell selection (GO:0045058)4.87921868
19response to pheromone (GO:0019236)4.81313071
20interferon-gamma production (GO:0032609)4.79472259
21T cell mediated immunity (GO:0002456)4.72748762
22positive regulation of gamma-delta T cell activation (GO:0046645)4.70160291
23positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.69580837
24regulation of gamma-delta T cell differentiation (GO:0045586)4.52141253
25response to interleukin-15 (GO:0070672)4.51423338
26positive regulation of T cell mediated cytotoxicity (GO:0001916)4.50660233
27T cell migration (GO:0072678)4.46860055
28regulation of chronic inflammatory response (GO:0002676)4.37437066
29positive regulation of granulocyte differentiation (GO:0030854)4.32765263
30regulation of leukocyte mediated cytotoxicity (GO:0001910)4.31939835
31regulation of T cell tolerance induction (GO:0002664)4.28311103
32positive regulation of leukocyte mediated cytotoxicity (GO:0001912)4.27555063
33positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.23603280
34tolerance induction (GO:0002507)4.13539749
35positive regulation of tolerance induction (GO:0002645)4.12940962
36regulation of cell killing (GO:0031341)4.03760239
37positive regulation of cell killing (GO:0031343)4.00832742
38antigen processing and presentation via MHC class Ib (GO:0002475)3.99049874
39positive regulation of natural killer cell mediated immunity (GO:0002717)3.98309671
40regulation of gamma-delta T cell activation (GO:0046643)3.97842085
41regulation of natural killer cell mediated immunity (GO:0002715)3.95887709
42regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.95887709
43positive regulation of alpha-beta T cell proliferation (GO:0046641)3.94552471
44Arp2/3 complex-mediated actin nucleation (GO:0034314)3.90654412
45regulation of necroptotic process (GO:0060544)3.85320262
46regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.80197183
47regulation of alpha-beta T cell proliferation (GO:0046640)3.78628286
48positive regulation of T cell differentiation in thymus (GO:0033089)3.70158906
49positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.69678803
50alpha-beta T cell differentiation (GO:0046632)3.69336125
51regulation of regulatory T cell differentiation (GO:0045589)3.68929640
52regulation of B cell receptor signaling pathway (GO:0050855)3.68003997
53T cell differentiation involved in immune response (GO:0002292)3.66907276
54alpha-beta T cell differentiation involved in immune response (GO:0002293)3.66907276
55alpha-beta T cell activation involved in immune response (GO:0002287)3.66907276
56actin nucleation (GO:0045010)3.64828978
57CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.60466600
58T-helper cell differentiation (GO:0042093)3.60466600
59regulation of tolerance induction (GO:0002643)3.60426172
60negative regulation of T cell mediated immunity (GO:0002710)3.59632075
61positive regulation of DNA recombination (GO:0045911)3.57762671
62negative regulation of necroptotic process (GO:0060546)3.50011211
63T cell receptor signaling pathway (GO:0050852)3.45260658
64regulation of interleukin-2 biosynthetic process (GO:0045076)3.42349974
65regulation of T cell mediated immunity (GO:0002709)3.39716071
66T cell homeostasis (GO:0043029)3.36842465
67positive regulation of T cell mediated immunity (GO:0002711)3.36778455
68negative regulation of lymphocyte mediated immunity (GO:0002707)3.33376346
69negative regulation of stress fiber assembly (GO:0051497)3.31628621
70regulation of defense response to virus by virus (GO:0050690)3.30242778
71positive regulation of lymphocyte mediated immunity (GO:0002708)3.29613376
72T cell differentiation (GO:0030217)3.22273575
73alpha-beta T cell activation (GO:0046631)3.20244038
74positive regulation of isotype switching (GO:0045830)3.19609360
75defense response to protozoan (GO:0042832)3.16466191
76lymphocyte costimulation (GO:0031294)3.16062269
77positive regulation of uterine smooth muscle contraction (GO:0070474)3.14331772
78negative regulation of interleukin-12 production (GO:0032695)3.13610182
79negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.13436704
80lymphocyte migration (GO:0072676)3.12957135
81mast cell activation (GO:0045576)3.11962874
82cytidine metabolic process (GO:0046087)3.11837946
83cytidine catabolic process (GO:0006216)3.11837946
84cytidine deamination (GO:0009972)3.11837946
85DNA deamination (GO:0045006)3.08682914
86positive regulation of calcium-mediated signaling (GO:0050850)3.05713661
87regulation of lymphocyte mediated immunity (GO:0002706)3.04908172
88CD4-positive, alpha-beta T cell differentiation (GO:0043367)3.04583916
89T cell costimulation (GO:0031295)3.03665129
90positive regulation of interleukin-10 production (GO:0032733)3.01244909
91tachykinin receptor signaling pathway (GO:0007217)2.98955881
92type I interferon signaling pathway (GO:0060337)2.98865888
93cellular response to type I interferon (GO:0071357)2.98865888
94positive regulation of adaptive immune response based on somatic recombination of immune receptors b2.98572546
95antigen receptor-mediated signaling pathway (GO:0050851)2.97042838
96response to type I interferon (GO:0034340)2.94926621
97positive regulation of interleukin-4 production (GO:0032753)2.93542504
98S-adenosylmethionine metabolic process (GO:0046500)2.93497801
99regulation of T cell apoptotic process (GO:0070232)2.93080747
100negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.91545967

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_20620947_ChIP-Seq_CD4_POS_T_Human6.84423905
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse6.46109306
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.76071761
4BP1_19119308_ChIP-ChIP_Hs578T_Human4.10279182
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.99196662
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.66381148
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.64326159
8RUNX_20019798_ChIP-Seq_JUKART_Human3.56471663
9MYB_26560356_Chip-Seq_TH2_Human3.46573535
10CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.16991444
11STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.91620568
12SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.89321299
13STAT4_19710469_ChIP-ChIP_TH1__Mouse2.89293928
14SMAD_19615063_ChIP-ChIP_OVARY_Human2.80808832
15NOTCH1_21737748_ChIP-Seq_TLL_Human2.67266151
16ELF1_17652178_ChIP-ChIP_JURKAT_Human2.45820534
17CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.41210920
18MYB_26560356_Chip-Seq_TH1_Human2.40834250
19MAF_26560356_Chip-Seq_TH1_Human2.40284578
20GATA3_27048872_Chip-Seq_THYMUS_Human2.28838743
21IRF8_21731497_ChIP-ChIP_J774_Mouse2.26861239
22UTX_26944678_Chip-Seq_JUKART_Human2.19643016
23NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.08640922
24MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.05321475
25RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.97308938
26FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.94067052
27LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.86969745
28GATA3_26560356_Chip-Seq_TH2_Human1.86316683
29MAF_26560356_Chip-Seq_TH2_Human1.83046614
30RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.80823153
31HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.73138645
32LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.56651908
33E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.47315305
34EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.42070584
35FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.41831274
36FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.41537176
37SPI1_23547873_ChIP-Seq_NB4_Human1.38572283
38SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.36463041
39GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.28412742
40SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.26151618
41MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.24436329
42IRF8_27001747_Chip-Seq_BMDM_Mouse1.20494015
43RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.18615923
44GABP_17652178_ChIP-ChIP_JURKAT_Human1.16524529
45VDR_23849224_ChIP-Seq_CD4+_Human1.14658198
46IKZF1_21737484_ChIP-ChIP_HCT116_Human1.10819162
47BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.10652807
48EST1_17652178_ChIP-ChIP_JURKAT_Human1.08380248
49EGR1_19032775_ChIP-ChIP_M12_Human1.07125282
50RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.04184893
51IGF1R_20145208_ChIP-Seq_DFB_Human1.03332591
52SPI1_23127762_ChIP-Seq_K562_Human1.02675204
53STAT6_21828071_ChIP-Seq_BEAS2B_Human1.02657619
54BCL6_27268052_Chip-Seq_Bcells_Human1.02524419
55SA1_27219007_Chip-Seq_Bcells_Human0.98629097
56GATA2_22383799_ChIP-Seq_G1ME_Mouse0.96993017
57FOXP3_21729870_ChIP-Seq_TREG_Human0.95578669
58PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.95560763
59NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.93352278
60YY1_21170310_ChIP-Seq_MESCs_Mouse0.93121862
61CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91119470
62TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.90466805
63NANOG_20526341_ChIP-Seq_ESCs_Human0.89428027
64MYC_22102868_ChIP-Seq_BL_Human0.87537553
65RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.85699976
66MYB_21317192_ChIP-Seq_ERMYB_Mouse0.85319859
67TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.84424229
68CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.83960946
69SPI1_20517297_ChIP-Seq_HL60_Human0.82617249
70BRD4_27068464_Chip-Seq_AML-cells_Mouse0.82189981
71FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82034362
72FLI1_27457419_Chip-Seq_LIVER_Mouse0.81764841
73TAF2_19829295_ChIP-Seq_ESCs_Human0.81269772
74SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.80095469
75PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.78445824
76CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.76715596
77TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.76163084
78GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.75943802
79KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.75850580
80TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.75502219
81SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.73664629
82FOXA1_27270436_Chip-Seq_PROSTATE_Human0.73339887
83FOXA1_25329375_ChIP-Seq_VCAP_Human0.73339887
84SCL_19346495_ChIP-Seq_HPC-7_Human0.72611576
85CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.70051097
86VDR_24763502_ChIP-Seq_THP-1_Human0.69671450
87PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.68935879
88ELF1_20517297_ChIP-Seq_JURKAT_Human0.67660188
89BCOR_27268052_Chip-Seq_Bcells_Human0.67514730
90FOXH1_21741376_ChIP-Seq_EPCs_Human0.66286515
91BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.66114106
92PRDM14_20953172_ChIP-Seq_ESCs_Human0.64935627
93SOX2_21211035_ChIP-Seq_LN229_Human0.64760726
94GATA3_21878914_ChIP-Seq_MCF-7_Human0.64592287
95OCT4_20526341_ChIP-Seq_ESCs_Human0.64240461
96PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.63894231
97FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.63431908
98STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.62190079
99GATA3_26560356_Chip-Seq_TH1_Human0.61872104
100ERA_21632823_ChIP-Seq_H3396_Human0.60331820

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to5.09593308
2MP0003763_abnormal_thymus_physiology4.05693483
3MP0001835_abnormal_antigen_presentation3.88256324
4MP0001348_abnormal_lacrimal_gland3.45906235
5MP0000685_abnormal_immune_system3.27190925
6MP0003436_decreased_susceptibility_to3.13012544
7MP0006082_CNS_inflammation3.00950049
8MP0005000_abnormal_immune_tolerance2.94113583
9MP0001800_abnormal_humoral_immune2.92438134
10MP0001873_stomach_inflammation2.82203580
11MP0009785_altered_susceptibility_to2.69016348
12MP0003646_muscle_fatigue2.68549031
13MP0005387_immune_system_phenotype2.63447982
14MP0001790_abnormal_immune_system2.63447982
15MP0005025_abnormal_response_to2.58218893
16MP0002723_abnormal_immune_serum2.52176989
17MP0002420_abnormal_adaptive_immunity2.50733063
18MP0001819_abnormal_immune_cell2.47740646
19MP0003724_increased_susceptibility_to2.45114271
20MP0002163_abnormal_gland_morphology2.43870901
21MP0009333_abnormal_splenocyte_physiolog2.43046641
22MP0002166_altered_tumor_susceptibility2.41797809
23MP0002452_abnormal_antigen_presenting2.23433956
24MP0010155_abnormal_intestine_physiology2.19702856
25MP0002277_abnormal_respiratory_mucosa2.18890596
26MP0001986_abnormal_taste_sensitivity2.13501486
27MP0002398_abnormal_bone_marrow2.02294665
28MP0002419_abnormal_innate_immunity1.99310237
29MP0000716_abnormal_immune_system1.97103155
30MP0000372_irregular_coat_pigmentation1.95249714
31MP0002933_joint_inflammation1.93042816
32MP0002148_abnormal_hypersensitivity_rea1.88789292
33MP0003866_abnormal_defecation1.86806613
34MP0002405_respiratory_system_inflammati1.85621842
35MP0000703_abnormal_thymus_morphology1.80580905
36MP0002132_abnormal_respiratory_system1.70995849
37MP0000604_amyloidosis1.66930607
38MP0002006_tumorigenesis1.64940159
39MP0002138_abnormal_hepatobiliary_system1.64140043
40MP0003252_abnormal_bile_duct1.58538406
41MP0002722_abnormal_immune_system1.55676519
42MP0000689_abnormal_spleen_morphology1.55603479
43MP0001845_abnormal_inflammatory_respons1.53421556
44MP0002429_abnormal_blood_cell1.46814630
45MP0005410_abnormal_fertilization1.45442226
46MP0008872_abnormal_physiological_respon1.42967970
47MP0004947_skin_inflammation1.41478628
48MP0001533_abnormal_skeleton_physiology1.38629965
49MP0005379_endocrine/exocrine_gland_phen1.34672710
50MP0008875_abnormal_xenobiotic_pharmacok1.29396937
51MP0005310_abnormal_salivary_gland1.25823483
52MP0008469_abnormal_protein_level1.24595893
53MP0002009_preneoplasia1.13678349
54MP0003300_gastrointestinal_ulcer1.07106989
55MP0002693_abnormal_pancreas_physiology1.06933622
56MP0005451_abnormal_body_composition1.05354372
57MP0005083_abnormal_biliary_tract1.02647816
58MP0009764_decreased_sensitivity_to1.01934543
59MP0003690_abnormal_glial_cell1.01653258
60MP0001968_abnormal_touch/_nociception1.01522232
61MP0004381_abnormal_hair_follicle0.99626071
62MP0005075_abnormal_melanosome_morpholog0.94263547
63MP0001765_abnormal_ion_homeostasis0.92672236
64MP0002396_abnormal_hematopoietic_system0.91377450
65MP0000465_gastrointestinal_hemorrhage0.89574021
66MP0003303_peritoneal_inflammation0.89370852
67MP0003075_altered_response_to0.88198951
68MP0005166_decreased_susceptibility_to0.87948548
69MP0005464_abnormal_platelet_physiology0.87916914
70MP0002876_abnormal_thyroid_physiology0.87172799
71MP0003806_abnormal_nucleotide_metabolis0.86006441
72MP0005423_abnormal_somatic_nervous0.85966685
73MP0002928_abnormal_bile_duct0.76615427
74MP0000858_altered_metastatic_potential0.75987324
75MP0010329_abnormal_lipoprotein_level0.72944154
76MP0002736_abnormal_nociception_after0.70217610
77MP0004130_abnormal_muscle_cell0.68208101
78MP0001501_abnormal_sleep_pattern0.66884697
79MP0001663_abnormal_digestive_system0.63894664
80MP0004142_abnormal_muscle_tone0.63730744
81MP0003448_altered_tumor_morphology0.61485409
82MP0000920_abnormal_myelination0.59572710
83MP0009763_increased_sensitivity_to0.57211272
84MP0001346_abnormal_lacrimal_gland0.55950733
85MP0000249_abnormal_blood_vessel0.54320278
86MP0005165_increased_susceptibility_to0.52435588
87MP0005390_skeleton_phenotype0.51536593
88MP0008874_decreased_physiological_sensi0.50405332
89MP0002019_abnormal_tumor_incidence0.50058769
90MP0003795_abnormal_bone_structure0.48916445
91MP0005636_abnormal_mineral_homeostasis0.48515965
92MP0001851_eye_inflammation0.48473011
93MP0008961_abnormal_basal_metabolism0.47591964
94MP0000750_abnormal_muscle_regeneration0.47321171
95MP0002837_dystrophic_cardiac_calcinosis0.44831323
96MP0009765_abnormal_xenobiotic_induced0.44133585
97MP0001542_abnormal_bone_strength0.41442989
98MP0002136_abnormal_kidney_physiology0.40910558
99MP0004145_abnormal_muscle_electrophysio0.40323445
100MP0002102_abnormal_ear_morphology0.40109293

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)6.01719008
2Severe combined immunodeficiency (HP:0004430)5.55365727
3T lymphocytopenia (HP:0005403)5.48511147
4Abnormality of T cell number (HP:0011839)5.31644925
5IgG deficiency (HP:0004315)5.22249469
6Elevated erythrocyte sedimentation rate (HP:0003565)4.86629120
7Aplastic anemia (HP:0001915)4.75710284
8Hypoproteinemia (HP:0003075)4.64155964
9Abnormality of T cells (HP:0002843)4.61889377
10Combined immunodeficiency (HP:0005387)4.40237680
11Eczematoid dermatitis (HP:0000976)4.35633251
12Hyperlipoproteinemia (HP:0010980)4.24196816
13Autoimmune hemolytic anemia (HP:0001890)4.22714441
14Chronic diarrhea (HP:0002028)4.02573403
15Oral leukoplakia (HP:0002745)3.90524267
16Abnormal delayed hypersensitivity skin test (HP:0002963)3.89347477
17Panhypogammaglobulinemia (HP:0003139)3.82110432
18Abnormality of T cell physiology (HP:0011840)3.77067904
19Recurrent fungal infections (HP:0002841)3.73374821
20Increased IgM level (HP:0003496)3.70757250
21Optic neuritis (HP:0100653)3.64922330
22Retrobulbar optic neuritis (HP:0100654)3.64922330
23Chronic mucocutaneous candidiasis (HP:0002728)3.63054448
24Recurrent cutaneous fungal infections (HP:0011370)3.63054448
25Increased intramyocellular lipid droplets (HP:0012240)3.57067387
26Myositis (HP:0100614)3.49420297
27Thyroiditis (HP:0100646)3.41832806
28Recurrent bronchitis (HP:0002837)3.37948253
29Orchitis (HP:0100796)3.36768930
30Encephalitis (HP:0002383)3.24090824
31Abnormality of eosinophils (HP:0001879)3.21165904
32Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.11793283
33Hypoplasia of the pons (HP:0012110)3.04663416
34Abnormality of the pons (HP:0007361)3.00727115
35Increased muscle lipid content (HP:0009058)2.94287282
36Pulmonary infiltrates (HP:0002113)2.89222008
37Neonatal respiratory distress (HP:0002643)2.79714507
38Slow saccadic eye movements (HP:0000514)2.77883434
39Autoimmune thrombocytopenia (HP:0001973)2.77742270
40Increased hepatocellular lipid droplets (HP:0006565)2.72990124
41Keratoconjunctivitis sicca (HP:0001097)2.66485420
42Leukocytosis (HP:0001974)2.63746813
43Keratoconjunctivitis (HP:0001096)2.59298181
44Absent rod-and cone-mediated responses on ERG (HP:0007688)2.58484124
45Bronchitis (HP:0012387)2.58433747
46Meningitis (HP:0001287)2.49818289
47Loss of speech (HP:0002371)2.48233350
48Recurrent viral infections (HP:0004429)2.48183786
49Vasculitis (HP:0002633)2.44838983
50Lymphopenia (HP:0001888)2.44568244
51Abnormality of cells of the lymphoid lineage (HP:0012140)2.41419201
52Hypoalbuminemia (HP:0003073)2.41042926
53Abnormal albumin level (HP:0012116)2.41042926
54Recurrent skin infections (HP:0001581)2.40571810
55Mesangial abnormality (HP:0001966)2.39035918
56Eosinophilia (HP:0001880)2.37477797
57Mediastinal lymphadenopathy (HP:0100721)2.36896308
58Hypergammaglobulinemia (HP:0010702)2.36074964
59B lymphocytopenia (HP:0010976)2.34658290
60Abnormality of macrophages (HP:0004311)2.34109821
61Radial bowing (HP:0002986)2.32572150
62Nasal polyposis (HP:0100582)2.32554519
63Hemoptysis (HP:0002105)2.31931365
64Joint swelling (HP:0001386)2.29088930
65Increased IgE level (HP:0003212)2.22601290
66Granulocytopenia (HP:0001913)2.22599622
67Agammaglobulinemia (HP:0004432)2.19563587
68Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.18751530
69IgM deficiency (HP:0002850)2.18687749
70Fatigue (HP:0012378)2.17161004
71Chronic otitis media (HP:0000389)2.14993257
72Pustule (HP:0200039)2.13745307
73Lymphoma (HP:0002665)2.13226521
74Hypoplasia of the thymus (HP:0000778)2.12220003
75Lipid accumulation in hepatocytes (HP:0006561)2.10815934
76Abnormality of B cell number (HP:0010975)2.09757145
77Gastrointestinal infarctions (HP:0005244)2.09275975
78Chronic obstructive pulmonary disease (HP:0006510)2.07701186
79Obstructive lung disease (HP:0006536)2.07701186
80Pancytopenia (HP:0001876)2.07623800
81Gangrene (HP:0100758)2.02422158
82Congenital stationary night blindness (HP:0007642)2.00127659
83Recurrent otitis media (HP:0000403)1.99534500
84Xanthomatosis (HP:0000991)1.97969472
85Abnormal rod and cone electroretinograms (HP:0008323)1.94173169
86Recurrent bacterial skin infections (HP:0005406)1.93507334
87Gastrointestinal inflammation (HP:0004386)1.92588857
88Dyskinesia (HP:0100660)1.92540112
89Exertional dyspnea (HP:0002875)1.91088741
90IgA deficiency (HP:0002720)1.91049969
91Symphalangism affecting the phalanges of the hand (HP:0009773)1.90119880
92Renal Fanconi syndrome (HP:0001994)1.90009541
93Abnormality of the nasal mucosa (HP:0000433)1.88908326
94Anorexia (HP:0002039)1.88808531
95Hypochromic anemia (HP:0001931)1.87368153
96Amyotrophic lateral sclerosis (HP:0007354)1.83978476
97Neutropenia (HP:0001875)1.80777476
98Inflammation of the large intestine (HP:0002037)1.80712397
99Bronchiectasis (HP:0002110)1.80335449
100Recurrent abscess formation (HP:0002722)1.77368386

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SCYL24.90709558
2MAP4K14.21239800
3TXK3.53536485
4KDR3.38309528
5RIPK43.32374706
6ITK2.99728014
7FES2.92714837
8ZAP702.85939221
9STK162.69126883
10MAP3K32.67612346
11MAP2K32.58857912
12TAOK22.23534578
13TAOK32.17066338
14MAP3K112.10041409
15BTK2.00040235
16TEC1.80969625
17PASK1.77666090
18CSK1.76577796
19STK241.73774148
20IKBKE1.62264607
21SYK1.59535139
22LCK1.57437937
23TRPM71.56016186
24TAOK11.51449935
25EPHB11.48175783
26ADRBK21.47009916
27PIM11.44932720
28TESK21.42349129
29BLK1.41038743
30GRK61.39666934
31MARK31.36822133
32TGFBR21.33716041
33JAK31.29604876
34MAP3K121.28366783
35HCK1.23782184
36LYN1.23742734
37STK38L1.23559537
38TYK21.21981186
39TNK21.14628027
40JAK11.14153815
41DAPK21.12526260
42HIPK21.11839284
43CSF1R1.11647252
44MAP2K61.08743910
45IKBKB0.94625666
46DAPK10.94087297
47MYLK0.89263246
48CAMKK10.86068625
49CAMKK20.84583583
50PRKCQ0.84154340
51STK100.81646628
52FRK0.79483054
53KIT0.77498745
54MST40.74598232
55MAP3K70.70051238
56BCR0.69351782
57BMPR20.67742162
58PIK3CG0.66911745
59MAP3K140.64359100
60AKT30.62975333
61GRK70.58460362
62ERBB30.54992445
63PINK10.52523931
64STK380.49091428
65NEK60.47969851
66TIE10.45130853
67FGR0.44937780
68STK40.43562372
69MAP3K50.43044620
70DYRK20.40788077
71ADRBK10.39744772
72IGF1R0.39191772
73TLK10.39016812
74CDK40.38151755
75PDK10.37896223
76TESK10.36962361
77INSR0.35298018
78FGFR40.35122076
79NLK0.33639991
80IRAK10.32404172
81FYN0.32248938
82JAK20.32217446
83ABL10.30846707
84PAK30.29513768
85DAPK30.29202019
86PRPF4B0.28653227
87TBK10.28297294
88IRAK40.27631975
89EGFR0.26821378
90BUB10.26054196
91CLK10.25514613
92MAPKAPK20.25107809
93PIM20.24583776
94PRKCH0.21304475
95OBSCN0.20624312
96NUAK10.19479969
97INSRR0.19015758
98FGFR30.17889138
99TYRO30.15848725
100PRKCD0.14297310

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053406.32033384
2Allograft rejection_Homo sapiens_hsa053303.77240946
3Autoimmune thyroid disease_Homo sapiens_hsa053203.54188846
4Antigen processing and presentation_Homo sapiens_hsa046123.41245140
5T cell receptor signaling pathway_Homo sapiens_hsa046603.19380864
6Graft-versus-host disease_Homo sapiens_hsa053322.97037919
7Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.80045452
8Hematopoietic cell lineage_Homo sapiens_hsa046402.64335729
9Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.46039837
10Intestinal immune network for IgA production_Homo sapiens_hsa046722.35694915
11NF-kappa B signaling pathway_Homo sapiens_hsa040642.33468654
12Measles_Homo sapiens_hsa051622.26535109
13Type I diabetes mellitus_Homo sapiens_hsa049402.19914769
14Proteasome_Homo sapiens_hsa030502.03272816
15Ribosome_Homo sapiens_hsa030101.95523472
16Asthma_Homo sapiens_hsa053101.90808994
17Jak-STAT signaling pathway_Homo sapiens_hsa046301.59103701
18RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.57576664
19Viral myocarditis_Homo sapiens_hsa054161.55723717
20Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.52293348
21Malaria_Homo sapiens_hsa051441.43940444
22NOD-like receptor signaling pathway_Homo sapiens_hsa046211.42290126
23Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.32792440
24Phototransduction_Homo sapiens_hsa047441.32602413
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.27545829
26Leishmaniasis_Homo sapiens_hsa051401.25329703
27Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.25014262
28Osteoclast differentiation_Homo sapiens_hsa043801.23691817
29African trypanosomiasis_Homo sapiens_hsa051431.21225544
30Nitrogen metabolism_Homo sapiens_hsa009101.20231925
31TNF signaling pathway_Homo sapiens_hsa046681.15557698
32Legionellosis_Homo sapiens_hsa051341.11169037
33Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.05182846
34Herpes simplex infection_Homo sapiens_hsa051681.03024997
35Staphylococcus aureus infection_Homo sapiens_hsa051500.99832395
36Toxoplasmosis_Homo sapiens_hsa051450.97503505
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.97162958
38Chemokine signaling pathway_Homo sapiens_hsa040620.91472623
39Toll-like receptor signaling pathway_Homo sapiens_hsa046200.86266979
40Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.85097682
41Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.84209620
42Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.79259478
43Oxidative phosphorylation_Homo sapiens_hsa001900.75472516
44Rheumatoid arthritis_Homo sapiens_hsa053230.75096774
45One carbon pool by folate_Homo sapiens_hsa006700.70950153
46Shigellosis_Homo sapiens_hsa051310.70263691
47Regulation of autophagy_Homo sapiens_hsa041400.69015827
48Linoleic acid metabolism_Homo sapiens_hsa005910.68335536
49Apoptosis_Homo sapiens_hsa042100.67506437
50Arachidonic acid metabolism_Homo sapiens_hsa005900.65770402
51Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.64686122
52Influenza A_Homo sapiens_hsa051640.63192509
53Olfactory transduction_Homo sapiens_hsa047400.62336907
54Steroid hormone biosynthesis_Homo sapiens_hsa001400.60427369
55Caffeine metabolism_Homo sapiens_hsa002320.59031368
56Renin secretion_Homo sapiens_hsa049240.57515513
57alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.51987962
58Platelet activation_Homo sapiens_hsa046110.51967323
59Tuberculosis_Homo sapiens_hsa051520.51737236
60Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.51385449
61Leukocyte transendothelial migration_Homo sapiens_hsa046700.50190730
62B cell receptor signaling pathway_Homo sapiens_hsa046620.47222001
63Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.43867142
64Morphine addiction_Homo sapiens_hsa050320.42563157
65Chemical carcinogenesis_Homo sapiens_hsa052040.42259806
66Transcriptional misregulation in cancer_Homo sapiens_hsa052020.40102268
67MAPK signaling pathway_Homo sapiens_hsa040100.37821598
68Epstein-Barr virus infection_Homo sapiens_hsa051690.34363489
69Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.33442746
70Hepatitis C_Homo sapiens_hsa051600.33284919
71Hepatitis B_Homo sapiens_hsa051610.33193283
72Carbohydrate digestion and absorption_Homo sapiens_hsa049730.32645430
73Endocytosis_Homo sapiens_hsa041440.32229883
74Nicotine addiction_Homo sapiens_hsa050330.32126113
75Cardiac muscle contraction_Homo sapiens_hsa042600.30926968
76Adipocytokine signaling pathway_Homo sapiens_hsa049200.30439613
77HTLV-I infection_Homo sapiens_hsa051660.29825261
78Ras signaling pathway_Homo sapiens_hsa040140.29753370
79Salmonella infection_Homo sapiens_hsa051320.29588441
80ABC transporters_Homo sapiens_hsa020100.29426669
81Glutathione metabolism_Homo sapiens_hsa004800.28213266
82Acute myeloid leukemia_Homo sapiens_hsa052210.27312245
83FoxO signaling pathway_Homo sapiens_hsa040680.27259331
84Insulin resistance_Homo sapiens_hsa049310.26107048
85SNARE interactions in vesicular transport_Homo sapiens_hsa041300.25252629
86Pertussis_Homo sapiens_hsa051330.24301453
87Salivary secretion_Homo sapiens_hsa049700.23735117
88Viral carcinogenesis_Homo sapiens_hsa052030.23645412
89Mineral absorption_Homo sapiens_hsa049780.22206499
90Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.22101893
91Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.20575957
92Systemic lupus erythematosus_Homo sapiens_hsa053220.19279155
93Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.18748104
94Primary bile acid biosynthesis_Homo sapiens_hsa001200.18501174
95Drug metabolism - other enzymes_Homo sapiens_hsa009830.17907302
96Ovarian steroidogenesis_Homo sapiens_hsa049130.17715175
97Collecting duct acid secretion_Homo sapiens_hsa049660.16188285
98Glycerolipid metabolism_Homo sapiens_hsa005610.15804360
99GABAergic synapse_Homo sapiens_hsa047270.13446288
100Retinol metabolism_Homo sapiens_hsa008300.11615394

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