TRBV9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1eosinophil chemotaxis (GO:0048245)9.38721196
2pyrimidine ribonucleoside catabolic process (GO:0046133)9.06781732
3regulation of activation of Janus kinase activity (GO:0010533)8.54916217
4eosinophil migration (GO:0072677)8.45086658
5negative regulation by host of viral transcription (GO:0043922)8.34281152
6regulation of chronic inflammatory response (GO:0002676)8.01962928
7DNA deamination (GO:0045006)7.21447623
8regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450917.13923979
9regulation of mononuclear cell migration (GO:0071675)7.07261345
10regulation of chemokine-mediated signaling pathway (GO:0070099)7.04859830
11monocyte chemotaxis (GO:0002548)6.93128837
12macrophage chemotaxis (GO:0048246)6.71179812
13regulation of regulatory T cell differentiation (GO:0045589)6.63409055
14regulation of macrophage chemotaxis (GO:0010758)6.54955924
15positive regulation of T cell chemotaxis (GO:0010820)6.45943102
16regulation of T cell chemotaxis (GO:0010819)6.45943102
17positive regulation of monocyte chemotaxis (GO:0090026)6.39132630
18regulation of lymphocyte chemotaxis (GO:1901623)6.25401906
19cellular response to interleukin-15 (GO:0071350)6.10836800
20positive regulation of T cell apoptotic process (GO:0070234)6.05100395
21positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)6.04314578
22negative regulation of T cell apoptotic process (GO:0070233)6.01242118
23positive regulation of natural killer cell mediated immunity (GO:0002717)5.96545389
24positive regulation of translational initiation (GO:0045948)5.43816247
25response to interleukin-15 (GO:0070672)5.42272701
26regulation of natural killer cell mediated cytotoxicity (GO:0042269)5.01696184
27regulation of natural killer cell mediated immunity (GO:0002715)5.01696184
28dendritic cell chemotaxis (GO:0002407)4.95201331
29modulation by host of symbiont transcription (GO:0052472)4.90222421
30modulation by host of viral transcription (GO:0043921)4.90222421
31positive regulation of interleukin-8 secretion (GO:2000484)4.81420671
32regulation of T cell tolerance induction (GO:0002664)4.78020152
33positive regulation of lymphocyte apoptotic process (GO:0070230)4.77076783
34negative regulation of B cell proliferation (GO:0030889)4.69615397
35positive regulation of calcium-mediated signaling (GO:0050850)4.69139337
36modulation of transcription in other organism involved in symbiotic interaction (GO:0052312)4.63173136
37granulocyte activation (GO:0036230)4.55973024
38positive regulation of lymphocyte migration (GO:2000403)4.54215686
39negative regulation of viral genome replication (GO:0045071)4.52161428
40positive regulation of leukocyte mediated cytotoxicity (GO:0001912)4.52159248
41regulation of interleukin-12 biosynthetic process (GO:0045075)4.44255195
42positive thymic T cell selection (GO:0045059)4.39716605
43negative regulation of viral transcription (GO:0032897)4.34149377
44regulation of monocyte chemotaxis (GO:0090025)4.30829581
45positive regulation of tolerance induction (GO:0002645)4.29944349
46positive T cell selection (GO:0043368)4.26849778
47regulation of interleukin-2 biosynthetic process (GO:0045076)4.25796864
48negative regulation of lymphocyte apoptotic process (GO:0070229)4.10199170
49positive regulation of cell killing (GO:0031343)4.07216615
50pyrimidine nucleoside catabolic process (GO:0046135)4.04567524
51regulation of leukocyte mediated cytotoxicity (GO:0001910)3.98916978
52positive regulation of gamma-delta T cell activation (GO:0046645)3.97300810
53regulation of T cell apoptotic process (GO:0070232)3.91695524
54regulation of tolerance induction (GO:0002643)3.86939621
55neutrophil activation (GO:0042119)3.86100091
56positive regulation of leukocyte apoptotic process (GO:2000108)3.84200068
57negative regulation of B cell activation (GO:0050869)3.83806565
58dendritic cell migration (GO:0036336)3.81687240
59antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.76922553
60positive regulation of cell adhesion mediated by integrin (GO:0033630)3.76400742
61T cell costimulation (GO:0031295)3.74220460
62lymphocyte costimulation (GO:0031294)3.70534300
63regulation of cell killing (GO:0031341)3.67773194
64positive regulation of smooth muscle cell migration (GO:0014911)3.64279213
65positive regulation of T cell migration (GO:2000406)3.61889902
66Arp2/3 complex-mediated actin nucleation (GO:0034314)3.61248771
67regulation of lymphocyte migration (GO:2000401)3.60202851
68regulation of homotypic cell-cell adhesion (GO:0034110)3.58022258
69thymic T cell selection (GO:0045061)3.53549460
70regulation of calcium-mediated signaling (GO:0050848)3.49970019
71cellular defense response (GO:0006968)3.47559898
72regulation of gamma-delta T cell differentiation (GO:0045586)3.47520462
73nucleoside diphosphate catabolic process (GO:0009134)3.39292160
74regulation of T cell migration (GO:2000404)3.38707384
75membrane raft organization (GO:0031579)3.37281650
76positive regulation of viral genome replication (GO:0045070)3.36721756
77negative T cell selection (GO:0043383)3.36671803
78T cell migration (GO:0072678)3.29515527
79regulation of interleukin-8 secretion (GO:2000482)3.28834309
80DNA demethylation (GO:0080111)3.26896486
81negative regulation of T cell activation (GO:0050868)3.26687492
82modification by host of symbiont morphology or physiology (GO:0051851)3.22888509
83positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.21164955
84localization within membrane (GO:0051668)3.20719131
85regulation of viral genome replication (GO:0045069)3.17952190
86negative regulation of T cell differentiation (GO:0045581)3.17015781
87regulation of T cell receptor signaling pathway (GO:0050856)3.12321121
88T cell receptor signaling pathway (GO:0050852)3.10457941
89T cell selection (GO:0045058)3.10372118
90actin nucleation (GO:0045010)3.08099443
91negative regulation of T cell receptor signaling pathway (GO:0050860)3.08076521
92activated T cell proliferation (GO:0050798)3.05660804
93positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.05226586
94negative regulation of viral process (GO:0048525)3.01548144
95lipopolysaccharide-mediated signaling pathway (GO:0031663)3.00575343
96positive regulation of interleukin-4 production (GO:0032753)2.99415387
97chemokine-mediated signaling pathway (GO:0070098)2.97809689
98cytidine deamination (GO:0009972)10.0110299
99cytidine metabolic process (GO:0046087)10.0110299
100cytidine catabolic process (GO:0006216)10.0110299

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.14690077
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.98247670
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.43129905
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.50046075
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.45785149
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.08957340
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.92977072
8MYB_26560356_Chip-Seq_TH2_Human2.87150227
9STAT4_19710469_ChIP-ChIP_TH1__Mouse2.84687688
10RUNX_20019798_ChIP-Seq_JUKART_Human2.50814062
11IRF8_21731497_ChIP-ChIP_J774_Mouse2.49352602
12TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.31432043
13GATA3_27048872_Chip-Seq_THYMUS_Human2.26596350
14STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.25305218
15RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.15393802
16MYB_26560356_Chip-Seq_TH1_Human2.02787467
17BP1_19119308_ChIP-ChIP_Hs578T_Human14.3508722
18ELF1_17652178_ChIP-ChIP_JURKAT_Human1.94818818
19FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.90972983
20MAF_26560356_Chip-Seq_TH2_Human1.83775270
21FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.76077970
22LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.75006848
23FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.73452731
24UTX_26944678_Chip-Seq_JUKART_Human1.69024413
25SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.66017714
26MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.63989109
27GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.60691727
28MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.58864269
29GATA3_26560356_Chip-Seq_TH2_Human1.49769579
30MAF_26560356_Chip-Seq_TH1_Human1.48654240
31NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.47550500
32STAT6_21828071_ChIP-Seq_BEAS2B_Human1.43006510
33MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.39113284
34HTT_18923047_ChIP-ChIP_STHdh_Human1.37210613
35KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.32664162
36SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.29680733
37LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.25516991
38RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.24329940
39IRF8_27001747_Chip-Seq_BMDM_Mouse1.23060060
40VDR_23849224_ChIP-Seq_CD4+_Human1.17545813
41GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.16948063
42TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.15900057
43ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.08844686
44JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.05974704
45TAF2_19829295_ChIP-Seq_ESCs_Human1.05467659
46RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.03859661
47FOXP3_21729870_ChIP-Seq_TREG_Human1.00893652
48CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.99906985
49GATA3_26560356_Chip-Seq_TH1_Human0.98718183
50PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.98328723
51GABP_17652178_ChIP-ChIP_JURKAT_Human0.98193156
52SPI1_23547873_ChIP-Seq_NB4_Human0.96308841
53VDR_22108803_ChIP-Seq_LS180_Human0.94681606
54NOTCH1_21737748_ChIP-Seq_TLL_Human0.94441367
55HOXB4_20404135_ChIP-ChIP_EML_Mouse0.91281042
56CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.88189906
57PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.87641195
58TP53_22573176_ChIP-Seq_HFKS_Human0.87155395
59SRY_22984422_ChIP-ChIP_TESTIS_Rat0.86148336
60GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.86034420
61P300_27268052_Chip-Seq_Bcells_Human0.83066111
62ELF1_20517297_ChIP-Seq_JURKAT_Human0.83005327
63SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.81417352
64RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.80119894
65E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.80073015
66GATA1_22025678_ChIP-Seq_K562_Human0.78684570
67POU5F1_16153702_ChIP-ChIP_HESCs_Human0.77248181
68BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.76720326
69BCL6_27268052_Chip-Seq_Bcells_Human0.76663645
70SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.75724664
71GATA6_21074721_ChIP-Seq_CACO-2_Human0.74157572
72EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.74028509
73PCGF2_27294783_Chip-Seq_NPCs_Mouse0.73730420
74CTCF_20526341_ChIP-Seq_ESCs_Human0.73507827
75CIITA_25753668_ChIP-Seq_RAJI_Human0.72929565
76TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.71963733
77GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.71921933
78POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.71644965
79GATA3_21878914_ChIP-Seq_MCF-7_Human0.71403936
80FLI1_21867929_ChIP-Seq_CD8_Mouse0.70969024
81YY1_22570637_ChIP-Seq_MALME-3M_Human0.70736412
82EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.69734528
83NANOG_20526341_ChIP-Seq_ESCs_Human0.68279160
84FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.67345288
85HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.66826731
86SRF_21415370_ChIP-Seq_HL-1_Mouse0.66449433
87RBPJ_21746931_ChIP-Seq_IB4_Human0.66180135
88RUNX1_22412390_ChIP-Seq_EML_Mouse0.65717203
89NANOG_19829295_ChIP-Seq_ESCs_Human0.63385225
90SOX2_19829295_ChIP-Seq_ESCs_Human0.63385225
91SA1_27219007_Chip-Seq_Bcells_Human0.63260776
92PRDM14_20953172_ChIP-Seq_ESCs_Human0.62903427
93FOXH1_21741376_ChIP-Seq_EPCs_Human0.61498852
94CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.60185333
95IGF1R_20145208_ChIP-Seq_DFB_Human0.59870699
96GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.59849699
97BCOR_27268052_Chip-Seq_Bcells_Human0.59744944
98EST1_17652178_ChIP-ChIP_JURKAT_Human0.59715516
99FLI1_27457419_Chip-Seq_LIVER_Mouse0.58497180
100TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.57727285

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to7.75869181
2MP0006082_CNS_inflammation4.15987190
3MP0003763_abnormal_thymus_physiology3.69095211
4MP0001873_stomach_inflammation3.41772551
5MP0009785_altered_susceptibility_to3.16022614
6MP0002148_abnormal_hypersensitivity_rea3.09491519
7MP0009333_abnormal_splenocyte_physiolog2.81687967
8MP0001800_abnormal_humoral_immune2.79457077
9MP0001835_abnormal_antigen_presentation2.70625100
10MP0005000_abnormal_immune_tolerance2.69773748
11MP0010307_abnormal_tumor_latency2.68936683
12MP0002723_abnormal_immune_serum2.64807078
13MP0003866_abnormal_defecation2.51975414
14MP0000569_abnormal_digit_pigmentation2.47029299
15MP0002420_abnormal_adaptive_immunity2.42727573
16MP0002877_abnormal_melanocyte_morpholog2.40477129
17MP0003045_fibrosis2.35862769
18MP0001819_abnormal_immune_cell2.35776800
19MP0002398_abnormal_bone_marrow2.19162549
20MP0005025_abnormal_response_to2.18642509
21MP0010155_abnormal_intestine_physiology2.18173147
22MP0001790_abnormal_immune_system2.16856558
23MP0005387_immune_system_phenotype2.16856558
24MP0004145_abnormal_muscle_electrophysio2.13247223
25MP0002163_abnormal_gland_morphology2.11873343
26MP0002405_respiratory_system_inflammati2.09520919
27MP0001188_hyperpigmentation2.01568567
28MP0002452_abnormal_antigen_presenting1.96959954
29MP0000716_abnormal_immune_system1.95620032
30MP0005310_abnormal_salivary_gland1.91508882
31MP0003786_premature_aging1.87291525
32MP0002933_joint_inflammation1.84453575
33MP0001853_heart_inflammation1.84314814
34MP0002722_abnormal_immune_system1.69032923
35MP0000689_abnormal_spleen_morphology1.65329373
36MP0000703_abnormal_thymus_morphology1.63327840
37MP0000685_abnormal_immune_system1.62200429
38MP0002429_abnormal_blood_cell1.56253679
39MP0001845_abnormal_inflammatory_respons1.55581685
40MP0005464_abnormal_platelet_physiology1.53091624
41MP0002277_abnormal_respiratory_mucosa1.48758685
42MP0003183_abnormal_peptide_metabolism1.45118658
43MP0003448_altered_tumor_morphology1.36363116
44MP0002419_abnormal_innate_immunity1.35602874
45MP0005174_abnormal_tail_pigmentation1.26715599
46MP0004147_increased_porphyrin_level1.23547636
47MP0005379_endocrine/exocrine_gland_phen1.22982075
48MP0003436_decreased_susceptibility_to1.19556052
49MP0003075_altered_response_to1.16787440
50MP0000920_abnormal_myelination1.14304734
51MP0002876_abnormal_thyroid_physiology1.14157320
52MP0002638_abnormal_pupillary_reflex1.13677557
53MP0004381_abnormal_hair_follicle1.10298318
54MP0009765_abnormal_xenobiotic_induced1.08708158
55MP0008469_abnormal_protein_level1.08229991
56MP0002909_abnormal_adrenal_gland1.06369505
57MP0000372_irregular_coat_pigmentation1.04281361
58MP0009763_increased_sensitivity_to1.03673257
59MP0001905_abnormal_dopamine_level1.00640037
60MP0000015_abnormal_ear_pigmentation0.91913484
61MP0001919_abnormal_reproductive_system0.88189041
62MP0005670_abnormal_white_adipose0.87986374
63MP0004947_skin_inflammation0.86671523
64MP0002166_altered_tumor_susceptibility0.86282498
65MP0001661_extended_life_span0.82544416
66MP0001727_abnormal_embryo_implantation0.77125494
67MP0002168_other_aberrant_phenotype0.76954316
68MP0002138_abnormal_hepatobiliary_system0.76089068
69MP0002019_abnormal_tumor_incidence0.74898369
70MP0002095_abnormal_skin_pigmentation0.74875626
71MP0002693_abnormal_pancreas_physiology0.74327583
72MP0003878_abnormal_ear_physiology0.73747489
73MP0005377_hearing/vestibular/ear_phenot0.73747489
74MP0005075_abnormal_melanosome_morpholog0.70832189
75MP0002006_tumorigenesis0.70382886
76MP0008873_increased_physiological_sensi0.69903565
77MP0004185_abnormal_adipocyte_glucose0.68485057
78MP0008007_abnormal_cellular_replicative0.66683059
79MP0009643_abnormal_urine_homeostasis0.62077811
80MP0001191_abnormal_skin_condition0.61557640
81MP0000858_altered_metastatic_potential0.60310517
82MP0004134_abnormal_chest_morphology0.58636876
83MP0003011_delayed_dark_adaptation0.58352851
84MP0002234_abnormal_pharynx_morphology0.55465809
85MP0000343_altered_response_to0.54628428
86MP0003806_abnormal_nucleotide_metabolis0.54425353
87MP0002136_abnormal_kidney_physiology0.51061928
88MP0001243_abnormal_dermal_layer0.50741567
89MP0005645_abnormal_hypothalamus_physiol0.49589851
90MP0002733_abnormal_thermal_nociception0.49063682
91MP0004043_abnormal_pH_regulation0.47874571
92MP0005083_abnormal_biliary_tract0.47686670
93MP0005389_reproductive_system_phenotype0.47191202
94MP0002090_abnormal_vision0.47038910
95MP0009764_decreased_sensitivity_to0.43956067
96MP0002083_premature_death0.43554007
97MP0001542_abnormal_bone_strength0.43475734
98MP0000371_diluted_coat_color0.43390755
99MP0005165_increased_susceptibility_to0.42537802
100MP0001968_abnormal_touch/_nociception0.41017259

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)9.76953521
2Abnormality of T cell number (HP:0011839)9.62778389
3Abnormality of T cells (HP:0002843)5.76667177
4Hypoproteinemia (HP:0003075)5.74371672
5Increased IgM level (HP:0003496)4.98859444
6Abnormal delayed hypersensitivity skin test (HP:0002963)4.98718409
7Chronic diarrhea (HP:0002028)4.98684370
8IgG deficiency (HP:0004315)4.90426146
9Autoimmune hemolytic anemia (HP:0001890)4.77220077
10Abnormality of the prostate (HP:0008775)4.26742224
11Severe combined immunodeficiency (HP:0004430)4.04712964
12Ureteral stenosis (HP:0000071)3.97391197
13Decreased activity of mitochondrial respiratory chain (HP:0008972)3.84855369
14Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.84855369
15Recurrent viral infections (HP:0004429)3.81283737
16Abnormality of eosinophils (HP:0001879)3.76393327
17Recurrent cutaneous fungal infections (HP:0011370)3.74316038
18Chronic mucocutaneous candidiasis (HP:0002728)3.74316038
19Ureteral obstruction (HP:0006000)3.61062418
20Stomatitis (HP:0010280)3.59541758
21Obstructive lung disease (HP:0006536)3.55386766
22Chronic obstructive pulmonary disease (HP:0006510)3.55386766
23Meningitis (HP:0001287)3.50528202
24Recurrent bronchitis (HP:0002837)3.50180141
25Thyroiditis (HP:0100646)3.49258334
26Cutaneous melanoma (HP:0012056)3.48695496
27Hypoplasia of the thymus (HP:0000778)3.38831381
28Autoimmune thrombocytopenia (HP:0001973)3.36978079
29Aplastic anemia (HP:0001915)3.34757327
30Hypoalbuminemia (HP:0003073)3.34600649
31Abnormal albumin level (HP:0012116)3.34600649
32Recurrent fungal infections (HP:0002841)3.26977900
33Combined immunodeficiency (HP:0005387)3.16882592
34Pustule (HP:0200039)3.16205281
35Gangrene (HP:0100758)3.11332529
36IgA deficiency (HP:0002720)3.04278569
37Encephalitis (HP:0002383)2.99807349
38Chest pain (HP:0100749)2.98832827
39Pulmonary infiltrates (HP:0002113)2.96200296
40Eosinophilia (HP:0001880)2.95810986
41Joint swelling (HP:0001386)2.92236554
42Hemoptysis (HP:0002105)2.91075671
43Hemiplegia (HP:0002301)2.89977046
44Leukocytosis (HP:0001974)2.87343551
45Abnormality of T cell physiology (HP:0011840)2.85581249
46Granulocytopenia (HP:0001913)2.78881613
47Abnormality of cells of the lymphoid lineage (HP:0012140)2.75547810
48Agammaglobulinemia (HP:0004432)2.74094216
49J-shaped sella turcica (HP:0002680)2.72703886
50Abnormality of macrophages (HP:0004311)2.72460525
51Vasculitis (HP:0002633)2.67543834
52Abnormality of the pleura (HP:0002103)2.60953993
53Recurrent skin infections (HP:0001581)2.60749086
543-Methylglutaconic aciduria (HP:0003535)2.59660173
55Pulmonary fibrosis (HP:0002206)2.52295399
56Squamous cell carcinoma (HP:0002860)2.51343827
57Lymphopenia (HP:0001888)2.44683025
58Melanoma (HP:0002861)2.44290172
59Abnormality of male internal genitalia (HP:0000022)2.43103517
60Bronchitis (HP:0012387)2.37877245
61Elevated erythrocyte sedimentation rate (HP:0003565)2.34958749
62Pulmonary embolism (HP:0002204)2.32634993
63Tetraplegia (HP:0002445)2.29048075
64IgM deficiency (HP:0002850)2.28599539
65Abnormality of B cell number (HP:0010975)2.19934068
66Recurrent abscess formation (HP:0002722)2.15700552
67Zonular cataract (HP:0010920)2.15296518
68Myositis (HP:0100614)2.14554491
69Entropion (HP:0000621)2.12495430
70Recurrent bacterial skin infections (HP:0005406)2.12045439
71Abnormality of the pericardium (HP:0001697)2.06970547
72Hepatosplenomegaly (HP:0001433)2.04277402
73Skin rash (HP:0000988)2.03891562
74Recurrent otitis media (HP:0000403)2.03219322
75Molar tooth sign on MRI (HP:0002419)1.98062276
76Abnormality of midbrain morphology (HP:0002418)1.98062276
77Carpal bone hypoplasia (HP:0001498)1.96551391
78Polyneuropathy (HP:0001271)1.96452694
79Lymphoma (HP:0002665)1.95361990
80Keratitis (HP:0000491)1.95015261
81Recurrent corneal erosions (HP:0000495)1.94771653
82Gastrointestinal infarctions (HP:0005244)1.93427782
83Increased intramyocellular lipid droplets (HP:0012240)1.93029842
84Retinopathy (HP:0000488)1.92793541
85Panhypogammaglobulinemia (HP:0003139)1.91038225
86Increased serum ferritin (HP:0003281)1.90095082
87Acute hepatic failure (HP:0006554)1.89898909
88Optic neuritis (HP:0100653)1.87722413
89Retrobulbar optic neuritis (HP:0100654)1.87722413
90Abnormality of DNA repair (HP:0003254)1.85424467
91Visual hallucinations (HP:0002367)1.83007430
92Abnormal mitochondria in muscle tissue (HP:0008316)1.81806856
93Acute necrotizing encephalopathy (HP:0006965)1.81724043
94Periorbital edema (HP:0100539)1.81375220
95Abnormality of the alveolar ridges (HP:0006477)1.81278113
96Pancreatitis (HP:0001733)1.80374338
97Hypochromic anemia (HP:0001931)1.77890634
98Facial edema (HP:0000282)1.76702065
99Glomerulopathy (HP:0100820)1.75829801
100Focal motor seizures (HP:0011153)1.70045841

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KDR4.20360278
2ITK2.72343541
3MAP4K12.49921151
4GRK72.38332108
5FES2.24588552
6PRKCQ2.06658379
7MAPKAPK32.02963435
8ADRBK22.02804512
9TXK11.5260531
10CSK1.96549691
11BUB11.89209562
12DAPK21.77115783
13BCKDK1.69855955
14LCK1.67127313
15TESK21.66227056
16WNK41.58600117
17TYRO31.55635866
18SYK1.55281684
19NTRK11.48374049
20MATK1.34389393
21ZAP701.22097090
22PIK3CA1.19749462
23BCR1.19644754
24TEC1.17243494
25NME11.14303043
26TBK11.13641370
27VRK21.08167035
28IKBKE1.06994649
29JAK31.05499052
30DAPK10.98230102
31MST40.90204438
32ZAK0.88408789
33PIM20.87733990
34BTK0.86922549
35IKBKB0.86310383
36JAK20.85126051
37MAP3K110.83405034
38NUAK10.81864290
39TRIM280.77313753
40FYN0.76739600
41VRK10.73427498
42LYN0.68652910
43GRK60.67740142
44PDGFRB0.67579069
45PIM10.66961044
46RIPK40.63605007
47CAMKK20.63397536
48FGFR10.63239340
49MAP4K20.62645617
50PIK3CG0.60742122
51GRK10.60219688
52CSF1R0.59649013
53MAP3K120.59472030
54CLK10.58882773
55MYLK0.53579978
56SCYL20.51515859
57ARAF0.51074877
58STK100.50496796
59OXSR10.49254137
60IRAK30.49133906
61LIMK10.48370520
62PDK10.47166151
63BLK0.46636203
64IRAK40.44319436
65INSR0.42991015
66MAPKAPK20.41040664
67MAPK110.39061164
68FRK0.38279909
69TLK10.38032109
70SRPK10.38014041
71CAMK2A0.37919754
72MAP3K60.36460244
73TAOK30.36052361
74IGF1R0.34960224
75TIE10.34139245
76MAP2K60.34099727
77BMPR20.32691489
78ROCK10.29487005
79ATR0.27992683
80PRKCA0.27602879
81PDK20.26913622
82GRK50.25009514
83AURKA0.22725487
84MAP3K140.21818963
85MELK0.21475516
86PRKACA0.21173360
87CAMK2D0.21126134
88OBSCN0.21026364
89TESK10.20514844
90TGFBR20.20205322
91CAMK2G0.20170437
92CSNK1A10.19972909
93MAPK30.19910522
94MAP3K70.19840162
95PDPK10.18794773
96CSNK1G30.18492685
97RPS6KA50.18287942
98PRKCB0.17701594
99INSRR0.17450104
100ABL10.14009101

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053406.21770296
2Autoimmune thyroid disease_Homo sapiens_hsa053204.38392662
3Graft-versus-host disease_Homo sapiens_hsa053323.89566831
4Antigen processing and presentation_Homo sapiens_hsa046123.70016767
5Allograft rejection_Homo sapiens_hsa053303.63344210
6Cytosolic DNA-sensing pathway_Homo sapiens_hsa046233.47441719
7Rheumatoid arthritis_Homo sapiens_hsa053233.37062126
8T cell receptor signaling pathway_Homo sapiens_hsa046603.13075394
9Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046503.12196085
10Hematopoietic cell lineage_Homo sapiens_hsa046403.08565629
11Type I diabetes mellitus_Homo sapiens_hsa049402.88010790
12Proteasome_Homo sapiens_hsa030502.76924802
13Measles_Homo sapiens_hsa051622.04126049
14Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.99895960
15Toll-like receptor signaling pathway_Homo sapiens_hsa046201.96581708
16Prion diseases_Homo sapiens_hsa050201.96098025
17NF-kappa B signaling pathway_Homo sapiens_hsa040641.95222322
18Salmonella infection_Homo sapiens_hsa051321.82457195
19Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.75164605
20Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.74687762
21Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.61822514
22Viral myocarditis_Homo sapiens_hsa054161.54461829
23NOD-like receptor signaling pathway_Homo sapiens_hsa046211.49468911
24Chemokine signaling pathway_Homo sapiens_hsa040621.36178087
25Asthma_Homo sapiens_hsa053101.35388395
26Oxidative phosphorylation_Homo sapiens_hsa001901.28770722
27Intestinal immune network for IgA production_Homo sapiens_hsa046721.22011639
28Parkinsons disease_Homo sapiens_hsa050121.13506511
29Staphylococcus aureus infection_Homo sapiens_hsa051501.05846292
30RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.94568493
31Apoptosis_Homo sapiens_hsa042100.84318022
32TNF signaling pathway_Homo sapiens_hsa046680.79152452
33Herpes simplex infection_Homo sapiens_hsa051680.78808778
34Shigellosis_Homo sapiens_hsa051310.78241268
35Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.77290537
36Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.77029693
37Jak-STAT signaling pathway_Homo sapiens_hsa046300.72708275
38Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.71987197
39Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.71686486
40Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.70706765
41Leishmaniasis_Homo sapiens_hsa051400.69707575
42Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.67613108
43Linoleic acid metabolism_Homo sapiens_hsa005910.66601767
44HTLV-I infection_Homo sapiens_hsa051660.65940292
45Alzheimers disease_Homo sapiens_hsa050100.64708672
46Influenza A_Homo sapiens_hsa051640.64160201
47Malaria_Homo sapiens_hsa051440.62932647
48African trypanosomiasis_Homo sapiens_hsa051430.61931973
49Osteoclast differentiation_Homo sapiens_hsa043800.61257781
50Systemic lupus erythematosus_Homo sapiens_hsa053220.61243465
51Protein export_Homo sapiens_hsa030600.53230161
52SNARE interactions in vesicular transport_Homo sapiens_hsa041300.51657623
53Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.50719235
54Epstein-Barr virus infection_Homo sapiens_hsa051690.45823979
55alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.43400984
56RNA polymerase_Homo sapiens_hsa030200.41015381
57Collecting duct acid secretion_Homo sapiens_hsa049660.39751040
58N-Glycan biosynthesis_Homo sapiens_hsa005100.39730622
59Fanconi anemia pathway_Homo sapiens_hsa034600.39605009
60Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.39501120
61Caffeine metabolism_Homo sapiens_hsa002320.35883108
62p53 signaling pathway_Homo sapiens_hsa041150.35808257
63Nucleotide excision repair_Homo sapiens_hsa034200.34823334
64Endocytosis_Homo sapiens_hsa041440.34320080
65Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.32522204
66Huntingtons disease_Homo sapiens_hsa050160.28176344
67Legionellosis_Homo sapiens_hsa051340.27809096
68Tuberculosis_Homo sapiens_hsa051520.25293850
69Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.24064350
70Peroxisome_Homo sapiens_hsa041460.22949344
71Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.21966290
72Lysosome_Homo sapiens_hsa041420.21033114
73Cardiac muscle contraction_Homo sapiens_hsa042600.20868966
74Phototransduction_Homo sapiens_hsa047440.20565517
75Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.20449705
76Vascular smooth muscle contraction_Homo sapiens_hsa042700.19887155
77Retinol metabolism_Homo sapiens_hsa008300.19364398
78Pyrimidine metabolism_Homo sapiens_hsa002400.17594242
79Homologous recombination_Homo sapiens_hsa034400.16841565
80Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.16521359
81Viral carcinogenesis_Homo sapiens_hsa052030.14224584
82Arachidonic acid metabolism_Homo sapiens_hsa005900.13483653
83Ether lipid metabolism_Homo sapiens_hsa005650.12101155
84Phagosome_Homo sapiens_hsa041450.11226747
85Purine metabolism_Homo sapiens_hsa002300.11041976
86Regulation of autophagy_Homo sapiens_hsa041400.09618315
87Alcoholism_Homo sapiens_hsa050340.06920760
88Transcriptional misregulation in cancer_Homo sapiens_hsa052020.06118888
89Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.05683607
90Nitrogen metabolism_Homo sapiens_hsa009100.03425961
91Adipocytokine signaling pathway_Homo sapiens_hsa049200.02603398
92Toxoplasmosis_Homo sapiens_hsa051450.02286035
93Ras signaling pathway_Homo sapiens_hsa040140.02039911
94RNA degradation_Homo sapiens_hsa030180.01745925
95Chemical carcinogenesis_Homo sapiens_hsa052040.01560928
96VEGF signaling pathway_Homo sapiens_hsa043700.00991030
97Non-small cell lung cancer_Homo sapiens_hsa052230.00678633
98Pertussis_Homo sapiens_hsa05133-0.0478184
99Propanoate metabolism_Homo sapiens_hsa00640-0.0422724
100Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072-0.0353899

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